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Diabetes in CKD

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https://www.readbyqxmd.com/read/29033503/the-management-and-prognostic-factors-of-acute-coronary-syndrome-evidence-from-the-taiwan-acute-coronary-syndrome-full-spectrum-registry
#1
REVIEW
Chun-Yuan Chu, Tsung-Hsien Lin, Wen-Ter Lai
Cardiovascular disease (CVD) accounts for approximately one-third of all global deaths, and acute coronary syndrome (ACS) is the most severe form of CVD. It is of notable importance to develop ACS strategies for reducing major adverse cardiac events (MACE) and preventing complications. In the Taiwan ACS Full Spectrum Registry, 1-year mortality among patients with ST-segment elevation myocardial infarction, non ST-segment elevation myocardial infarction and unstable angina was 6.1%, 10.1%, and 6.2%, respectively...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29031006/the-kidney-and-cvots
#2
EDITORIAL
Zachary Bloomgarden
Chronic kidney disease (CKD) affects a substantial minority of persons with type 2 diabetes. Analysis of US National Health and Nutrition Examination Survey (NHANES) datasets from 2007 through 2012 showed stage 3 or worse disease (estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m(2) ) in nearly one in five patients, with increasing age, blood pressure, obesity and levels of glycemia all associated with higher likelihood ((1) ), comparable to findings from surveys from many other areas, which also show micro- or macroalbuminuria to be present in one sixth to one third of diabetic persons ((2) )...
October 14, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29021336/pooled-analysis-of-multiple-crossover-trials-to-optimize-individual-therapy-response-to-renin-angiotensin-aldosterone-system-intervention
#3
Sergei I Petrykiv, Gozewijn Dirk Laverman, Frederik Persson, Liffert Vogt, Peter Rossing, Martin H de Borst, Ronald T Gansevoort, Dick de Zeeuw, Hiddo J L Heerspink
BACKGROUND AND OBJECTIVES: In the treatment of CKD, individual patients show a wide variation in their response to many drugs, including renin-angiotensin-aldosterone system inhibitors (RAASi). To investigate whether therapy resistance to RAASi can be overcome by uptitrating the dose of drug, changing the mode of intervention (with drugs from similar or different classes), or lowering dietary sodium intake, we meta-analyzed individual responses to different modes of interventions. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Randomized crossover trials were analyzed to assess correlation of individual responses to RAASi and nonsteroidal anti-inflammatory drugs (NSAIDs; n=395 patients)...
October 11, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29021274/prevalence-and-outcomes-of-left-sided-valvular-heart-disease-associated-with-chronic-kidney-disease
#4
Zainab Samad, Joseph A Sivak, Matthew Phelan, Phillip J Schulte, Uptal Patel, Eric J Velazquez
BACKGROUND: Chronic kidney disease (CKD) is an adverse prognostic marker for valve intervention patients; however, the prevalence and related outcomes of valvular heart disease in CKD patients is unknown. METHODS AND RESULTS: Included patients underwent echocardiography (1999-2013), had serum creatinine values within 6 months before index echocardiogram, and had no history of valve surgery. CKD was defined as diagnosis based on the International Classification of Diseases, Ninth Revision or an estimated glomerular filtration rate <60 mL/min per 1...
October 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29020374/asian-dust-exposure-triggers-acute-myocardial-infarction
#5
Sunao Kojima, Takehiro Michikawa, Kayo Ueda, Tetsuo Sakamoto, Kunihiko Matsui, Tomoko Kojima, Kenichi Tsujita, Hisao Ogawa, Hiroshi Nitta, Akinori Takami
Aims: To elucidate whether Asian dust is associated with the incidence of acute myocardial infarction (AMI) and to clarify whether patients who are highly sensitive to Asian dust will develop AMI. Methods and results: Twenty-one participating institutions located throughout Kumamoto Prefecture and capable of performing coronary intervention were included in the study. Data for ground-level observations of Asian dust events were measured at the Kumamoto Local Meteorological Observatory...
August 29, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28993865/two-year-cortical-and-trabecular-bone-loss-in-ckd-5d-biochemical-and-clinical-predictors
#6
H H Malluche, M-C Monier-Faugere, G Blomquist, D L Davenport
This prospective two-year study of patients on chronic dialysis measured changes in bone mineral density (BMD). Patients with higher baseline BMD and shorter dialysis vintage lost more bone. Treatment with anti-hypertensives acting on the central nervous system was protective against bone loss. Baseline serum levels of sclerostin and bone-specific alkaline phosphatase predicted bone loss. INTRODUCTION: This prospective 2-year study of chronic kidney disease on dialysis (CKD-5D) patients assessed trabecular and cortical bone loss at the hip and spine and examined potential demographic, clinical, and serum biochemical predictors of bone loss...
October 9, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28993503/myh9-e1841k-mutation-augments-proteinuria-and-podocyte-injury-and-migration
#7
Sylvia Cechova, Fan Dong, Fang Chan, Michael J Kelley, Phillip Ruiz, Thu H Le
Intronic variants of the MYH9 gene that encodes the nonmuscle myosin heavy chain IIA are associated with diabetic nephropathy in European Americans and with sickle cell disease-associated nephropathy. However, the causal functional variants of MYH9 have remained elusive. Rare missense mutations in MYH9 cause macrothrombocytopenia and are occasionally associated with development of nephropathy. The E1841K mutation is among the common MYH9 missense mutations and has been associated with nephropathy in some carriers...
October 9, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28992280/plasma-biomarkers-improve-prediction-of-diabetic-kidney-disease-in-adults-with-type-1-diabetes-over-a-12-year-follow-up-cacti-study
#8
Petter Bjornstad, Laura Pyle, David Z I Cherney, Richard J Johnson, Rachel Sippl, Randy Wong, Marian Rewers, Janet K Snell-Bergeon
Background: The objective of the study was to determine whether plasma biomarkers of kidney injury improve the prediction of diabetic kidney disease (DKD) in adults with type 1 diabetes (T1D) over a period of 12 years. Methods: Participants ( n  = 527, 53% females) in the Coronary Artery Calcification in T1D (CACTI) Study were examined during 2002-04, at a mean (± standard deviation) age of 39.6 ± 9.0 years with 24.8 years as the median duration of diabetes...
August 21, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28992249/association-of-dipstick-hematuria-with-all-cause-mortality-in-the-general-population-results-from-the-specific-health-check-and-guidance-program-in-japan
#9
Kunitoshi Iseki, Tsuneo Konta, Koichi Asahi, Kunihiro Yamagata, Shouichi Fujimoto, Kazuhiko Tsuruya, Ichiei Narita, Masato Kasahara, Yugo Shibagaki, Toshiki Moriyama, Masahide Kondo, Chiho Iseki, Tsuyoshi Watanabe
Background: Dipstick urine tests are used for general health screening in Japan. The effects of this screening on mortality have not been examined, especially with regard to hematuria. Methods: Subjects were those who participated in the 2008 Tokutei-Kenshin (nationwide specific health check and guidance program) in six districts in Japan. Using the national database of death certificates from 2008 to 2012, we identified subjects who might have died. We verified the candidates in collaboration with the regional National Health Insurance agency and public health nurses...
July 12, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28992221/the-diabetes-pandemic-suggests-unmet-needs-for-ckd-with-diabetes-in-addition-to-diabetic-nephropathy-implications-for-pre-clinical-research-and-drug-testing
#10
Lidia Anguiano Gómez, Yutian Lei, Satish Kumar Devarapu, Hans-Joachim Anders
Curing 'diabetic nephropathy' is considered an unmet medical need of high priority. We propose to question the concept of 'diabetic nephropathy' that implies diabetes as the predominant cause of kidney disease, which may not apply to the majority of type 2 diabetics approaching end-stage kidney disease. With the onset of diabetes, hyperglycaemia/sodium-glucose co-transporter-2-driven glomerular hyperfiltration promotes nephron hypertrophy, which, however, on its own, causes proteinuria not before a decade later, probably because podocyte hypertrophy can usually accommodate an increase in the filtration surface...
July 31, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28989092/advanced-liver-fibrosis-but-not-steatosis-is-independently-associated-with-albuminuria-in-chinese-patients-with-type-2-diabetes
#11
Ming-Wai Yeung, Grace Lai-Hung Wong, Kai Chow Choi, Andrea On-Yan Luk, Raymond Kwok, Sally She-Ting Shu, Anthony Wing-Hung Chan, Eric Siu Him Lau, Ronald Ching Wan Ma, Henry Lik-Yuen Chan, Juliana Chung-Ngor Chan, Vincent Wai-Sun Wong, Alice Pik-Shan Kong
BACKGROUND & AIMS: Increasing evidence suggests that non-alcoholic fatty liver disease (NAFLD) may be an independent risk factor for chronic kidney disease (CKD). Given the high prevalence of NAFLD among patients with diabetes who are also at risk for CKD, we aimed to investigate the association between NAFLD and albuminuria, a marker commonly found in diabetic nephropathy. METHODS: This study included a cohort of Chinese patients with type 2 diabetes from the Hong Kong Diabetes Registry recruited between March 2013 and May 2014...
October 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28987723/low-dose-aspirin-increases-15-epi-lipoxin-a4-levels-in-diabetic-chronic-kidney-disease-patients
#12
Marian Goicoechea, Maria Dolores Sanchez-Niño, Alberto Ortiz, Soledad García de Vinuesa, Borja Quiroga, Carmen Bernis, Enrique Morales, Gema Fernández-Juarez, Patricia de Sequera, Ursula Verdalles, Eduardo Verde, José Luño
BACKGROUND: Resolution of inflammation is regulated by endogenous lipid mediators, such as lipoxins and their epimers, including 15-epi-lipoxin A4 (15-epi-LXA4). However, there is no information on 15-epi-LXA4 and its in vivo regulation in chronic kidney disease (CKD) patients. STUDY DESIGN: Open label randomized clinical trial. SETTING AND PARTICIPANTS: 50 participants with chronic kidney disease (CKD) stage 3 and 4 without prior cardiovascular disease (25 in the aspirin group and 25 in the standard group) followed for 46 months...
October 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28978205/all-cause-costs-increase-exponentially-with-increased-chronic-kidney-disease-stage
#13
Ladan Golestaneh, Paula J Alvarez, Nancy L Reaven, Susan E Funk, Karen J McGaughey, Alain Romero, Melanie S Brenner, Macaulay Onuigbo
OBJECTIVE: To evaluate the economic impact of chronic kidney disease (CKD) on US health plans. STUDY DESIGN: A retrospective analysis identified patients with a renin-angiotensin-aldosterone system inhibitor (RAASi) prescription from an electronic medical record (EMR) database (Humedica); those with =90 days in =1 CKD stage were selected based on estimated glomerular filtration rate or diagnosis code, and a cohort on RAASi medications without CKD was selected. Costs for specific services obtained from OptumInsight were applied to services in EMR data of patients aged <65 years (commercial) and =65 years (Medicare)...
June 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28977924/antihyperglycemic-treatment-in-patients-with-type-2-diabetes-in-italy-the-impact-of-age-and-kidney-function
#14
Sandro Gentile, Pamela Piscitelli, Francesca Viazzi, Giuseppina Russo, Antonio Ceriello, Carlo Giorda, Piero Guida, Paola Fioretto, Roberto Pontremoli, Felice Strollo, Salvatore De Cosmo
We describe AHA utilization pattern according to age and renal function in type 2 diabetes mellitus (T2DM), in real-life conditions. The analysis was performed using the data set of electronic medical records collected between 1 January and 31 December, 2011 in 207 Italian diabetes centers. The study population consisted of 157,595 individuals with T2DM. The AHA treatment regimens was evaluated. Kidney function was assessed by eGFR, estimated using the CKD-EPI formula. Other determinations: HbA1c, blood pressure (BP), low- density lipoprotein (LDL-c), total and high density lipoprotein cholesterol (TC and HDL-c), triglycerides (TG) and serum uric acid (SUA)...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976899/community-noise-exposure-and-its-effect-on-blood-pressure-and-renal-function-in-patients-with-hypertension-and-cardiovascular-disease
#15
Angel M Dzhambov, Mariya P Tokmakova, Penka D Gatseva, Nikolai G Zdravkov, Dolina G Gencheva, Nevena G Ivanova, Krasimir I Karastanev, Stefka V Vladeva, Aleksandar T Donchev, Svetlan M Dermendzhiev
BACKGROUND: Road traffic noise (RTN) is a risk factor for cardiovascular disease (CVD) and hypertension; however, few studies have looked into its association with blood pressure (BP) and renal function in patients with prior CVD. AIM: This study aimed to explore the effect of residential RTN exposure on BP and renal function in patients with CVD from Plovdiv Province. MATERIALS AND METHODS: We included 217 patients with ischemic heart disease and/or hypertension from three tertiary hospitals in the city of Plovdiv (March - May 2016)...
September 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28976724/impact-of-glycemic-control-on-the-diabetes-complications-severity-index-score-and-development-of-complications-in-people-with-newly-diagnosed-type-2-diabetes
#16
Kevin M Pantalone, Anita D Misra-Hebert, Todd M Hobbs, Brian J Wells, Sheldon X Kong, Kevin Chagin, Tanujit Dey, Adam Milinovich, Wayne Weng, Janine M Bauman, Bartolome Burguera, Robert S Zimmerman, Michael W Kattan
AIMS: To assess the longitudinal accumulation of diabetes-related complications and the impact of glycemic control on the diabetes complications severity index (DCSI) score in people with newly-diagnosed type 2 diabetes (T2D). METHODS: A retrospective cohort study was conducted using electronic health records (EHR) from a large integrated healthcare system. People with newly-diagnosed T2D were identified between 2005-2016 and stratified by initial glycosylated hemoglobin (A1C) category (<7%, <8%, ≥8%)...
October 4, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28976071/prevalence-of-and-predictive-factor-for-abdominal-aortic-calcification-in-thai-chronic-kidney-disease-patients
#17
Dusit Lumlertgul, Surasak Kantachuvesiri, Somboon Apichaiyingyurd, Worapot Treamtrakanpon, Manoch Rattanasompattikul, Pongsathorn Gojaseni, Prasert Thanakitcharu, Thananda Trakarnvanich, Ussanee Poonvivatchaikarn, Kriengsak Vareesangthip
Presence and severity of cardiovascular calcifications strongly predict cardiovascular morbidity and mortality in patients with CKD. This multicenter, cross-sectional study primarily aimed to determine prevalence of abdominal aortic calcification (AAC) detected by plain lateral abdominal radiograph, and secondarily aimed to assess predictive factors for AAC. Patients (N = 1500), aged 18-70 years, with CKD stages 3-5D for ≥3 months prior to evaluation, were enrolled at 24 study centers in Thailand; 54...
October 4, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28975087/on-the-occasion-of-world-kidney-day-2017-obesity-and-its-relationship-with-chronic-kidney-disease
#18
REVIEW
Leila Mahmoodnia, Mohammad Reza Tamadon
CONTEXT: Numerous studies have reported the impact of obesity in the incidence of chronic kidney disease (CKD). Some studies have suggested the direct role of obesity in the incidence of CKD, while some other studies suggest an indirect effect caused by the effects of obesity on blood pressure and diabetes. EVIDENCE ACQUISITION: PubMed, EBSCO, Web of Science, directory of open access journals (DOAJ), EMBASE, and Google Scholar have been searched. RESULTS: Recent studies have presented more strong evidences on the role of obesity on the incidence of CKD...
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28973352/plasma-leucine-rich-alpha-2-glycoprotein-1-predicts-rapid-egfr-decline-and-albuminuria-progression-in-type-2-diabetes
#19
Jian-Jun Liu, Sharon Li Ting Pek, Kevin Ang, Subramaniam Tavintharan, Su Chi Lim
Context: Abnormal angiogenesis plays an important role in pathogenesis of diabetic kidney disease (DKD). Leucine-rich-alpha 2-glycoprotein 1 (LRG1) is a novel angiogenic factor. Objective: To study whether plasma LRG1 may independently predict progression of DKD in individuals with type 2 diabetes mellitus (T2DM). Design and Setting: Prospective cohort study in a regional hospital. Patients: 1226 T2DM participants were followed for 3...
June 30, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28971592/residual-renal-function-in-hemodialysis-and-inflammation
#20
Patricia de Sequera, Elena Corchete, Lourdes Bohorquez, Marta Albalate, Rafael Perez-Garcia, Matilde Alique, María Marques, Estefanya García-Menéndez, José Portolés, Rafael Ramirez
Residual renal function (RRF) has an important effect on uremic toxin clearance, on volume control, on quality of life, and on mortality. In patients with chronic kidney disease (CKD), microinflammation with an increased percentage of CD14(+) /CD16(++) inflammatory monocytes has been reported, even with no clinical evidence of inflammation. No correlation has been established between these and RRF in hemodialysis (HD) patients. Our objective was to assess the relationship between RRF and the inflammatory parameters in HD patients...
October 3, 2017: Therapeutic Apheresis and Dialysis
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