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https://www.readbyqxmd.com/read/29045629/signs-and-symptoms-of-group-a-versus-non-group-a-strep-throat-a-meta-analysis
#1
Thuy N Thai, Ariella P Dale, Mark H Ebell
Introduction: Both non-Group A streptococcal (non-GAS) pharyngitis and Group A streptococcal (GAS) pharyngitis are commonly found in patients with sore throat. It is not known whether or not they present with similar signs and symptoms compared to patients with non-streptococcal pharyngitis. Methods: MEDLINE was searched for prospective studies that reported throat culture for both GAS and non-GAS as a reference standard, and reported at least one sign, symptom, or the Centor score...
October 13, 2017: Family Practice
https://www.readbyqxmd.com/read/28991775/evidence-based-practice-in-using-antibiotics-for-acute-tonsillitis-in-primary-care-practice
#2
Valentina Risteska Nejashmikj, Snezana Stojkovska, Irena Kondova Topuzovska, Katarina Stavrikj
The increased use of antibiotics for acute tonsillitis is a public health problem. 80% of the antibiotic prescriptions for acute tonsillitis are done in the Primary Care practice (PCP). The inappropriate use of the antibiotic causes bacterial resistance and treatment failure. Only patients with acute tonsillitis caused by Group A beta-hemolytic streptococcus (GAS) have benefit of the antibiotic treatment, which is a predict cause in 5-20%. In order to assess the antibiotic prescribing for acute tonsillitis by the doctors in the PCP in Macedonia we use the data from the national project about antibiotic prescribing for acute respiratory tract infections which was conducted in November 2014 during a period of 4 weeks as part of the E-quality program sponsored by the IPCRG...
September 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28932455/pseudosymmetry-and-high-z-structures-the-case-of-rac-2r-2-r-5-s-2-methyl-5-1r-2r-5s-5-s-1-4-4-5-tetra-methyl-dihydro-3-h-3-8-dioxa-spiro-bi-cyclo-3-2-1-octane-2-2-furan-5-yl-3-4-1-2-3-4-hexa-hydro-2-2-bi-furan-5-2h-one
#3
Vincenzo Piccialli, Angela Tuzi, Roberto Centore
The title compound, C22H34O6, is one of the products obtained by oxidation of squalene with the catalytic system RuO4(cat.)/NaIO4. It crystallizes in the P-1 space group, with four crystallographically independent mol-ecules related by a pseudo-C2 symmetry axis. The structural analysis also shows that the title compound is isomeric with two products previously reported in the literature and that are obtained by the same reaction procedure. In particular, out of the seven chiral C atoms present in the mol-ecule, the title compound shows the opposite configuration at, respectively, four and two chiral centres with respect to the isomeric compounds...
September 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28765457/trends-in-behavioral-sciences-education-in-dental-schools-1926-to-2016
#4
Linda Centore
This article outlines the journey of behavioral sciences education from a multidisciplinary array of topics to a discipline with a name, core identity, and mission in dental schools' curricula. While not exhaustive, it covers pivotal events from the time of the Gies report in 1926 to the present. Strengths and weaknesses of current behavioral sciences instruction in dental schools are discussed, along with identification of future opportunities and potential threats. Suggestions for future directions for behavioral sciences and new roles for behavioral sciences faculty in dental schools are proposed...
August 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28699945/contextual-influences-of-trainee-characteristics-and-daily-workload-on-trainee-learning-preferences
#5
Brita Roy, Nidhi Huff, Carlos Estrada, Analia Castiglioni, Lisa Willett, Robert Centor
We previously defined teaching domains necessary for successful inpatient medicine attending rounds from the trainees' perspective in Role Modeling, Learning Environment, Teaching Process and Team Management. We sought to understand whether trainee characteristics and daily fluctuations in workload influence the prioritization of these domains. We conducted a prospective observational study in general medicine inpatient wards at a university, Veterans Affairs, and a county hospital affiliated with one academic institution over the course of 6 months...
July 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28529798/crystal-structure-of-a-new-spiro-polytetra-hydro-furan-compound-with-translational-pseudosymmetry-rac-2s-2-s-5-r-2-methyl-5-1r-2r-5s-5-r-1-4-4-5-tetra-methyl-dihydro-3-h-3-8-dioxa-spiro-bi-cyclo-3-2-1-octane-2-2-furan-5-yl-hexa-hydro-2-2-bi-furan-5-2h-one
#6
Vincenzo Piccialli, Angela Tuzi, Roberto Centore
The title compound, C22H34O6, is a product of oxidation of squalene with the catalytic system RuO4(cat.)/NaIO4. The asymmetric unit contains two crystallographically independent mol-ecules of very similar geometry approximately related by the non-crystallographic translation vector c/2. As a consequence, the average diffracted intensity in the hkl layers with odd l is systematically lower than in the layers with even l. In one mol-ecule, the lactone ring and part of the adjacent tetra-hydro-furan ring are disordered over two orientations with refined occupancy ratio of 0...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28470130/impact-of-centor-scores-on-determining-antibiotic-prescribing-in-children
#7
Joseph Freer, Tasneem Ally, Rossa Brugha
Purpose The purpose of this paper is to establish the effect of incorporating Centor scoring into antibiotic prescribing in primary care in London, UK, before and after the introduction of an educational package and prescribing software tool. Design/methodology/approach A quality improvement project with analysis of all sore throat presentations in patients aged 3-14 years, in two phases. Phase 1 (retrospective): 1 January-31 December 2013, followed by an intervention (software tool/education package) and Phase 2 (prospective): 1 March 2014-28 February 2015...
May 8, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28469911/improving-antimicrobial-prescribing-practice-for-sore-throat-symptoms-in-a-general-practice-setting
#8
Mohammad Razai, Kamal Hussain
Acute sore throat is a common presentation in primary care settings. We aimed to improve our compliance with national antibiotic guidelines for sore throat symptoms to 90% in 3 months' time period. The national guidelines are based on Centor criteria. A retrospective audit of 102 patient records with sore throat symptoms presenting between 1 January to 30 December 2015 showed that over 50% were given antibiotics. Those who were prescribed antibiotics, 27% did not meet NICE criteria and 85% of patients were given immediate antibiotic prescription...
2017: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/28452478/solid-state-separation-and-isolation-of-tautomers-of-fused-ring-triazolotriazoles
#9
Roberto Centore, Carla Manfredi, Amedeo Capobianco, Sabato Volino, Maria Vittoria Ferrara, Antonio Carella, Sandra Fusco, Andrea Peluso
Fine control of the tautomeric forms of [1,2,4]triazolo[3,2-c][1,2,4]triazole derivatives in acidic conditions has been achieved by acting on the electronic character of the substituent at position 7 of the heterobicycle and on the counterion. Strong electron releasing or electron withdrawing substituents lead almost exclusively to a single tautomeric form, the 1H-3H or the 2H-3H, respectively. In the case of the phenol substituent, both tautomeric forms are present in comparable amount in solution; the two tautomers can also be selectively precipitated in different crystalline salts using suitable counterions...
May 5, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28429165/the-use-of-rapid-test-quikread-go%C3%A2-strep-a-in-bacterial-pharyngotonsillitis-diagnosing-and-therapeutic-decisions
#10
E Stefaniuk, K Bosacka, M Wanke-Rytt, W Hryniewicz
Group A Streptococci (GAS) are the main causative agents of bacterial pharyngitis, which require antibiotic therapy. Rapid diagnostic tests detecting GAS combined with Centor/McIsaac score enable accurate differential diagnosis (viral vs. bacterial) and prompt commencement of targeted treatment. The aim of this study was to assess the specificity, sensitivity, PPV and NPV of QuikRead go® Strep A (Orion Diagnostica Oy, Finland) recommended for the detection of GAS in pharyngeal swabs. Quick diagnostic test results were compared with physical examination findings, Centor/McIsaac score and results of reference testing (conventional microbial cultures)...
April 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28345083/cal-b-catalyzed-regioselective-bulk-polymerization-of-l-aspartic-acid-diethyl-ester-to-%C3%AE-linked-polypeptides
#11
Filbert Totsingan, Robert Centore, Richard A Gross
This paper reports that the bulk polymerization of l-aspartic acid diethyl ester catalyzed by immobilized CAL-B at 80 °C for 24 h gives primarily (∼95%) α-linked poly(l-aspartate) in 70% yield with DPavg = 50 and regioselectivity (α/β) = 94 : 6. Plots of log{[M]0/[M]t} vs. time and DPavgvs. conversion indicate that this polymerization proceeds in a controlled manner by a chain-growth mechanism up to 90% conversion. Thereafter, competition occurs between chain growth and step mechanisms.
March 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28217338/5-amino-1-2-3-o-iso-propyl-idene-d-ribit-yl-1h-imidazole-4-carboxamide-a-crystal-structure-with-z-4
#12
Vincenzo Piccialli, Nicola Borbone, Giorgia Oliviero, Gennaro Piccialli, Stefano D'Errico, Roberto Centore
The title compound, C12H20N4O5, crystallizes in the monoclinic space group P21, with four crystallographically independent mol-ecules in the asymmetric unit. The four mol-ecules have a very similar conformation that is basically determined by the formation of two intra-molecular hydrogen bonds between the amino NH2 donors and the carbonyl and ring O-atom acceptors, forming, respectively, R(6) and R(7) ring motifs.. In the crystal, inter-molecular hydrogen bonding leads to the formation of R2(2)(10) ring patterns, involving one amide CONH2 donor and an imidazole N-atom acceptor...
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28081323/acute-exudative-tonsillitis-in-adults-the-use-of-the-centor-scoreand-some-laboratory-tests
#13
Yavuz Furuncuoğlu, Filiz Sağlam, Ahmet Kutluhan
BACKGROUND/AIM: The aim of our study was to determine the usefulness of the Centor score and some basic laboratory tests (complete blood count and C-reactive protein) for the differential diagnosis of exudative tonsillitis due to Group A β-hemolytic streptococcus (GABHS) or due to non-GABHS agents. MATERIALS AND METHODS: The data of clinical and laboratory characteristics of the patients diagnosed with exudative tonsillitis were collected and statistically compared between those having positive GABHS throat culture result and those who were negative for any bacterial agent...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28052179/sensitivity-for-diagnosing-group-a-streptococcal-pharyngitis-from-manufacturers-is-10-higher-than-reported-in-peer-reviewed-publications
#14
Raj Vachhani, Toral Patel, Robert M Centor, Carlos A Estrada
OBJECTIVES: Meta-analyses based on peer-reviewed publications report a sensitivity of approximately 85% for rapid antigen streptococcus tests to diagnose group A streptococcal (GAS) pharyngitis. Because these meta-analyses excluded package inserts, we examined the test characteristics of rapid antigen streptococcal tests and molecular methods that manufacturers report in their package inserts. METHODS: We included tests available in the US market (Food and Drug Administration, period searched 1993-2015) and used package insert data to calculate pooled sensitivity and specificity...
January 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28040511/fusobacterium-necrophorum-tonsillitis-with-mild-case-of-lemierre-s-syndrome
#15
Pavan Kumar Panchavati, Bhavini Kar, Ali Hassoun, Robert M Centor
No abstract text is available yet for this article.
February 2017: Anaerobe
https://www.readbyqxmd.com/read/27848011/clinical-value-of-antistreptolysin-o-levels-in-adult-patients-with-tonsillitis-report-i
#16
Vladimir Trushin, Moshe Englender
To assess the clinical value of antistreptolysin O (ASO) level in adult patients with acute tonsillitis of group A beta-hemolytic streptococcus (GABHS) etiology and its interaction with the Centor score and throat cultures data. ASO antibody titers and throat cultures were obtained from 260 adult patients with acute tonsillitis of GABHS etiology initially proven by the Centor score. The results were compared with the group of 100 adult patients with recurrent tonsillitis who underwent tonsillectomy and with the group of 100 healthy adults...
April 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27769576/survey-of-temperature-reaction-time-and-ultrasound-irradiation-power-on-sonochemical-synthesis-of-two-new-nanostructured-lead-ii-coordination-supramolecule-compounds
#17
Payam Hayati, AliReza Rezvani, Ali Morsali, Pascal Retailleau, Roberto Centore
Nanoparticles of two new 0D, lead(II) coordination supramolecular compounds, [Pb(L)2(I)2] (1) and [Pb(L)(L(/))(H2O)]·3H2O (2), (L=1,10-phenanthroline monohydrate, L(/)=2,6-pyridinedicarboxlic acid), have been synthesized by a sonochemical process and characterized by scanning electron microscopy (SEM), field emission scanning electron microscopy (FE-SEM), X-ray powder diffraction (XRPD), FT-IR spectroscopy and elemental analyses. The single crystal X-ray data of compounds show that the Pb ion is six coordinated in both 1 and 2...
March 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27618925/a-randomized-controlled-study-of-5-and-10%C3%A2-days-treatment-with-phenoxymethylpenicillin-for-pharyngotonsillitis-caused-by-streptococcus-group-a-a-protocol-study
#18
RANDOMIZED CONTROLLED TRIAL
Gunilla Skoog, Charlotta Edlund, Christian G Giske, Sigvard Mölstad, Christer Norman, Pär-Daniel Sundvall, Katarina Hedin
BACKGROUND: In 2014 the Swedish government assigned to The Public Health Agency of Sweden to conduct studies to evaluate optimal use of existing antibiotic agents. The aim is to optimize drug use and dosing regimens to improve the clinical efficacy. The present study was selected following a structured prioritizing process by independent experts. METHODS: This phase IV study is a randomized, open-label, multicenter study with non-inferiority design regarding the therapeutic use of penicillin V with two parallel groups...
September 13, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27573720/appropriateness-of-diagnosis-of-streptococcal-pharyngitis-among-thai-community-pharmacists-according-to-the-centor-criteria
#19
Woranuch Saengcharoen, Pornchanok Jaisawang, Palita Udomcharoensab, Kittika Buathong, Sanguan Lerkiatbundit
Background Inappropriate use of antibiotic treatment for pharyngitis by community pharmacists is prevalent in developing countries. Little is known about how the pharmacists identify patients with bacterial pharyngitis. Objective To ascertain the appropriateness of diagnosis of streptococcal pharyngitis among Thai community pharmacists according to the Centor criteria and to identify factors related to antibiotic dispensing. Setting 1040 Thai community pharmacists. Method A cross-sectional survey of community pharmacists was conducted in November 2012 to March 2013...
October 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27568201/a-systematic-review-of-fusobacterium-necrophorum-positive-acute-tonsillitis-prevalence-methods-of-detection-patient-characteristics-and-the-usefulness-of-the-centor-score
#20
REVIEW
T E Klug, M Rusan, K Fuursted, T Ovesen, A W Jorgensen
The purpose of this study was to review the current evidence for an association between Fusobacterium necrophorum (FN) and acute tonsillitis (AT), to assess the prevalence of FN in AT, to identify the better FN detection method, and to characterize the clinical characteristics of FN-positive patients with uncomplicated AT. A systematic literature search was conducted in the PubMed, EMBASE, and SweMed+ databases for studies reporting on the recovery rates of FN in patients with AT. A total of 498 unique records were identified...
December 2016: European Journal of Clinical Microbiology & Infectious Diseases
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