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Ramin Nourinia, Tahmineh Motevasseli, Zahra Tofighi
Objective: To report a case of neurofibromatosis-1 (NF-1) with retinal vasoproliferative tumor (RVPT) and macular edema and exudation that was successfully treated with intravitreal bevacizumab (IVB). Method: A retrospective case report of patient with neurofibromatosis, retinal vasoproliferative tumor and macular edema who received three monthly intravitreal injections of bevacizumab. Optical coherence tomography (OCT) and fluorescein angiography (FAG) before and three months after treatment were done. Results: Macular edema and exudation of the right eye was effectively resolved with IVB injection and vascularity of RVPT significantly decreased after treatment with IVB...
2016: GMS Ophthalmol Cases
Fereshteh Safari, Shahnaz Shekarforoosh, Tahmineh Hashemi, Simin Namvar Aghdash, Asefeh Fekri, Fatemeh Safari
The aim of this study was to investigate the effect of sirtinol, as an inhibitor of sirtuin NAD-dependent histone deacetylases, on myocardial ischemia reperfusion injury following early and late ischemia preconditioning (IPC). Rats underwent sustained ischemia and reperfusion (IR) alone or proceeded by early or late IPC. Sirtinol (S) was administered before IPC. Arrhythmias were evaluated based on the Lambeth model. Infarct size (IS) was measured using triphenyltetrazolium chloride staining. The transcription level of antioxidant-coding genes was assessed by real-time PCR...
September 27, 2016: Journal of Physiological Sciences: JPS
Reyhaneh Sabourian, Elahe Karimpour-Razkenari, Mina Saeedi, Maryam S Bagheri, Mahnaz Khanavi, Narges Sadati, Tahmineh Akbarzadeh, Mohammad R S Ardekani
BACKGROUND: In recent years, rapid population growth and unsafe abortions have emerged as controversial health issues in some countries. Hence, safe and effective contraceptive methods or agents have attracted a great deal of attention and the corresponding market has been widely expanded. OBJECTIVE: In this study, we present a review profiting from Iranian Traditional Medicine (ITM) to introduce expedient plants as efficient contraceptive agents. METHODS: Medicinal plants suggested as contraceptive agents were obtained from ITM text books and they were also investigated using search engines to confirm their in vitro and in vivo efficacy...
2016: Current Pharmaceutical Biotechnology
Behnam Behnoush, Nasim Tavakoli, Elham Bazmi, Fariborz Nateghi Fard, Mohammad Hossein Pourgharib Shahi, Arash Okazi, Tahmineh Mokhtari
BACKGROUND: Universal goniometer (UG) is commonly used as a standard method to evaluate range of motion (ROM) as part of joint motions. It has some restrictions, such as involvement of both hands of the physician, leads to instability of hands and error. Nowadays smartphones usage has been increasing due to its easy application. OBJECTIVES: The study was designed to compare the smartphone inclinometer-based app and UG in evaluation of ROM of elbow. MATERIALS AND METHODS: The maximum ROM of elbow in position of flexion and pronation and supination of forearm were examined in 60 healthy volunteers with UG and smartphone...
June 2016: Asian Journal of Sports Medicine
Reyhaneh Sabourian, Elahe Karimpour-Razkenari, Mina Saeedi, Maryam Seyed Bagheria, Mahnaz Khanavi, Narges Sadati, Tahmineh Akbarzadeh, Mohammad Reza Shams Ardekani
Background In recent years, rapid population growth and unsafe abortions have emerged as controversial health issues in some countries. Hence, safe and effective contraceptive methods or agents have attracted a great deal of attention and the corresponding market has been widely expanded. Objective In this study, we present a review profiting from Iranian Traditional Medicine (ITM) to introduce expedient plants as efficient contraceptive agents. Methods Medicinal plants suggested as contraceptive agents were obtained from ITM text books and they were also investigated using search engines to confirm their in vitro and in vivo efficacy...
August 8, 2016: Current Pharmaceutical Biotechnology
Nayereh Vahedi Mazdabadi, Elahe Karimpour Razkenari, Mina Saeedi, Tahmineh Akbarzadeh, Mohammad Toushih
BACKGROUND: It is evident that infant's umbilical cord is essential for its survival and growth. In the past, it was not considered as a necessary tissue. However, nowadays, it has attracted lots of attention and its relation to different diseases has been demonstrated. In Iranian traditional medicine, caring for newborn's umbilical cord has been frequently recommended and it has been associated with different diseases. METHODS: Herein, Iranian traditional medicine resources such as "Qanun-fil-Tibb", "Exir-e-Azam", and "Tib-e-Akbari" were studied...
May 2016: Iranian Journal of Medical Sciences
Tahmineh Mousavi, Shafik Dharamsi, Susan Forwell, Elizabeth Dean
Life Capability is the first and most fundamental of Nussbaum's 10 Central Human Functional Capabilities (CHFCs). This capability refers to a person having a quality life of normal duration. The purpose of this study was to explore the views' of occupational therapists about Life Capability, specifically, their perspectives of this capability and its perceived relevance to practice. Semi-structured interviews with 14 occupational therapists in British Columbia, Canada, were conducted and thematically analyzed...
October 2015: OTJR: Occupation, Participation and Health
Hassan Ashktorab, Pia Hermann, Mehdi Nouraie, Babak Shokrani, Edward Lee, Tahmineh Haidary, Hassan Brim, Ulrike Stein
BACKGROUND: Colorectal cancer is a preventable disease if caught at early stages. This disease is highly aggressive and has a higher incidence in African Americans. Several biomarkers and mutations of aggressive tumor behavior have been defined such as metastasis-associated in colon cancer 1 (MACC1) that was associated with metastasis in colorectal cancer patients. Here, we aim to assess colon tissue MACC1 protein and circulating MACC1 transcripts in colon preneoplastic and neoplastic African American patients...
2016: Journal of Translational Medicine
Mozhgan Rezaei Kanavi, Mohammad Ali Javadi, Tahmineh Motevasseli, Tahereh Chamani, Mahnoush Rezaei Kanavi, Bahareh Kheiri, Sare Safi
PURPOSE: To report changing trends in indications and techniques of corneal transplantation in Iran. METHODS: We reviewed eye bank records of 47,129 patients who had undergone corneal transplantation between 2006 and 2013 at different eye centers throughout Iran. RESULTS: The most common indication for corneal transplantation was keratoconus (KCN, n = 21,350 eyes, 45.3%), followed by bullous keratopathy (BK, n = 8,566 eyes, 18.2%), corneal opacity and scar (COS, n = 7,158 eyes, 15...
April 2016: Journal of Ophthalmic & Vision Research
Tahmineh Mehrabi, Alireza Ariafard
The mechanism of twofold hydroarylation of terminal alkynes with pyrrole catalyzed by a cationic gold(i) complex was investigated using DFT. It was found that while both the hydroarylation reactions proceed via a Friedel-Crafts-type mechanism, the first hydroarylation is directly promoted by gold(i) but the second hydroarylation by a proton released through interaction of the alkene product with gold-bound acidic organic species such as acetic acid and terminal alkynes.
August 4, 2016: Chemical Communications: Chem Comm
Maria Mohammadian, Sadegh Chinikar, Zakkyeh Telmadarraiy, Hassan Vatandoost, Mohammad Ali Oshaghi, Ahmad Ali Hanafi-Bojd, Mohammad Mehdi Sedaghat, Mehdi Noroozi, Faezeh Faghihi, Tahmineh Jalali, Sahar Khakifirouz, Nariman Shahhosseini, Firoozeh Farhadpour
BACKGROUND: Crimean-Congo Hemorrhagic Fever (CCHF) is a feverous and hemorrhagic disease endemic in some parts of Iran and caused by an arbovirus related to Bunyaviridae family and Nairovirusgenus. The main virus reservoir in the nature is ticks, however small vertebrates and a wide range of domestic and wild animals are regarded as reservoir hosts. This study was conducted to determine the infection rate of CCHF virus in hard ticks of Sarpole-Zahab County, Kermanshah province, west of Iran...
September 2016: Journal of Arthropod-borne Diseases
Mohsen Champour, Sadegh Chinikar, Gholamreza Mohammadi, Gholamreza Razmi, Ehsan Mostafavi, Nariman Shah-Hosseini, Sahar Khakifirouz, Tahmineh Jalali
BACKGROUND: This comprehensive study was conducted on multi-purpose one-humped camel (Camelus dromedarius) sera and ticks to assess the epidemiological aspects of the Crimean-Congo hemorrhagic fever virus (CCHFV) in northeast Iran. METHODS: From May 2012 to January 2013, eleven cities were randomly selected in the Khorasan Provinces of Iran as "clusters," and at least 14 one-humped camels were sampled from each area. Reverse transcriptase polymerase chain reaction was used for the detection of the CCHFV genome in ticks...
June 2016: Journal of Arthropod-borne Diseases
Sadegh Chinikar, Saeid Bouzari, Mohammad Ali Shokrgozar, Ehsan Mostafavi, Tahmineh Jalali, Sahar Khakifirouz, Norbert Nowotny, Anthony R Fooks, Nariman Shah-Hosseini
BACKGROUND: Crimean Congo hemorrhagic fever virus (CCHFV) is a member of the Bunyaviridae family and Nairovirus genus. It has a negative-sense, single stranded RNA genome approximately 19.2 kb, containing the Small, Medium, and Large segments. CCHFVs are relatively divergent in their genome sequence and grouped in seven distinct clades based on S-segment sequence analysis and six clades based on M-segment sequences. Our aim was to obtain new insights into the molecular epidemiology of CCHFV in Iran...
June 2016: Journal of Arthropod-borne Diseases
Tahmineh Salehian, Saidzaker Saeedinejad, Mohammad Behnammoghadam, Mohsen Shafiee, Sima Mohammadhossini, Zargham Behnammoghadam, Aziz Behnammoghadam, Soheil Ebrahimpour, Akvan Paymard
Myocardial infarction causes limitations in the physical activity and perturbation of quality of life.The aim of this study was to evaluate the effect of eye movements desensitization and reprocessing (EMDR) on the quality of life of these patients. This study was conducted in two groups as the before and after while the effect of eye movements desensitization and reprocessing on the quality of life of the patients with Myocardial infarction. Sampling was done based on the purposive sampling. Patients were randomly divided into two experimental and control groups (30 patients in each group)...
2016: Global Journal of Health Science
Zahra Najafi, Mina Saeedi, Mohammad Mahdavi, Reyhaneh Sabourian, Mahnaz Khanavi, Maliheh Barazandeh Tehrani, Farshad Homayouni Moghadam, Najmeh Edraki, Elahe Karimpor-Razkenari, Mohammad Sharifzadeh, Alireza Foroumadi, Abbas Shafiee, Tahmineh Akbarzadeh
A novel series of acridine-chromenone and quinoline-chromenone hybrids were designed, synthesized, and evaluated as anti-Alzheimer's agents. All synthesized compounds were evaluated as cholinesterases (ChEs) inhibitors and among them, 7-(4-(6-chloro-2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamino)phenoxy)-4-methyl-2H-chromen-2-one (8e) exhibited the most potent anti-acetylcholinesterase (AChE) inhibitory activity (IC50=16.17μM) comparing with rivastigmine (IC50=11.07μM) as the reference drug. Also, compound 8e was assessed for its β-secretase (BACE1) inhibitory and neuroprotective activities which demonstrated satisfactory results...
August 2016: Bioorganic Chemistry
Hetalkumar D Patel, Pavel Nikitin, Thomas Gesner, James J Lin, David T Barkan, Claudio Ciferri, Andrea Carfi, Tahmineh Akbarnejad Yazdi, Peter Skewes-Cox, Brigitte Wiedmann, Nadine Jarousse, Weidong Zhong, Adam Feire, Christy M Hebner
Human cytomegalovirus (HCMV) infection is usually benign in healthy individuals but can cause life-threatening disease in those with compromised immune systems. Approved drugs available to treat HCMV disease, including ganciclovir, cidofovir, and foscarnet, have significant toxicities that limit their use in certain patient populations. LJP538 and LJP539 are human monoclonal antibodies that are being evaluated as immunoglobulin therapeutics. The antibodies target glycoproteins gB and the gH/gL/UL128/UL130/UL131a pentameric complex, respectively...
August 2016: Antimicrobial Agents and Chemotherapy
Maryam Asli, Tahmineh Kandelouei, Koroush Rahimyan, Foad Davoodbeglou, Maryam Vaezjalali
BACKGROUND: Hepatitis B virus (HBV) infection is a major health problem worldwide. OBJECTIVES: The aim of this study was to investigate the frequency of occult hepatitis B infection (OBI) and its associated risk factors, together with the molecular characterization of the virus in injecting drug users of Tehran. PATIENTS AND METHODS: The study consisted of 229 injecting drug users. Serum samples were collected and tested for the presence of hepatitis B core antibody (HBcAb) and hepatitis B surface antigen (HBsAg) by an enzyme-linked immunosorbent assay (ELISA)...
March 2016: Hepatitis Monthly
Mahmoud Jabalameli, Amin Moradi, Abolfazl Bagherifard, Mehran Radi, Tahmineh Mokhtari
BACKGROUND: Evaluating the landmarks for rotation of the distal femur is a challenge for orthopedic surgeons. Although the posterior femoral condyle axis is a good landmark for surgeons, the surgical transepicondylar axis may be a better option with the help of preoperative CT scanning. The purpose of this study was to ascertain relationships among the axes' guiding distal femur rotational alignment in preoperative CT scans of Iranian patients who were candidates for total knee arthroplasty and the effects of age, gender, and knee alignment on these relationships...
April 2016: Archives of Bone and Joint Surgery
Mina Cheraghi Niroumand, Mohammad Hosein Farzaei, Elahe Karimpour Razkenari, Gholamreza Amin, Mahnaz Khanavi, Tahmineh Akbarzadeh, Mohammad Reza Shams-Ardekani
CONTEXT: Insects can be the cause of major ecological problems; they can transmit microbes and parasites that affect humans, and damage food crops, trees, and homes. The total economic cost of insect-related damage and disease is immeasurable. In traditional Iranian medicine (TIM), several medicinal plants have been identified as insecticides or insect repellents, but many of them are still unknown. Therefore, the aim of this study was to review the insecticidal or insect repellent activity of certain medicinal plants described in TIM...
February 2016: Iranian Red Crescent Medical Journal
Fereshteh Golfakhrabadi, Mohammad Reza Shams Ardekani, Soodabeh Saeidnia, Fatemeh Yousefbeyk, Hossein Jamalifar, Nasrin Ramezani, Tahmineh Akbarzadeh, Mahnaz Khanavi
Ferulago carduchorum (Apiaceae family) is an endemic plant of Iran. The crude extract and four fractions of aerial parts of F. carduchorum in two vegetative stages (flower and fruit) were studied for their total phenolic contents, antimicrobial and antioxidant activities using folin-ciocalteu assay, micro dilution method and DPPH assay, respectively. The results indicated that the best antioxidant activity was determined in flower crude extract (IC50=0.44 mg/mL). The flower ethyl acetate fraction (FLE) showed better antimicrobial and antifungal activities than other fractions...
March 2016: Pakistan Journal of Pharmaceutical Sciences
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