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https://www.readbyqxmd.com/read/28417026/cardiovascular-complications-of-acute-amphetamine-abuse-cross-sectional-study
#1
Elham Bazmi, Farinaz Mousavi, Leila Giahchin, Tahmineh Mokhtari, Behnam Behnoush
OBJECTIVES: This study aimed to evaluate cardiovascular complications among patients who abuse amphetamines. METHODS: This cross-sectional study took place between April 2014 and April 2015 among 3,870 patients referred to the Toxicology Emergency Department of Baharlou Hospital, Tehran University of Medical Sciences, Tehran, Iran. Those with clinical signs of drug abuse and positive urine screening tests were included in the study, while cases of chronic abuse were excluded...
February 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28367649/the-relationship-between-delivery-mode-and-children-s-growth-from-birth-to-6-months
#2
Fahimeh Sehhatie Shafaie, Mohammad Asghari Jafarabadi, Majid Mahalleie, Tahmineh Malekzadeh, Mohammad Malekzadeh
BACKGROUND: Children's growth is one of the important components of health affected by various environmental factors like delivery type. This study aimed at determining the relationship between delivery mode and children's growth from birth to six months. METHODS: In this prospective cohort study, the growth indices were studied on 526 children (272 Natural Vaginal Deliveries (NVDs) and 254 Caesarean sections (C/S) who were only breastfed. The primary samples consisted of pregnant women referred to Yasuj and Gachsaran Hospitals and health centers in 2014 - 15...
April 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28351943/apc-but-not-obesity-synergizes-with-pten-to-drive-intestinal-stem-cell-tumors
#3
Tahmineh Tabrizian, Donghai Wang, Fangxia Guan, Zunju Hu, Amanda Beck, Fabien Delahaye, Derek M Huffman
Obesity is a major risk factor for colorectal cancer and can accelerate Lgr5+ intestinal stem cell (ISC)-derived tumorigenesis following inactivation of Apc. However, whether non-canonical pathways involving PI3K-Akt signaling in ISCs can lead to tumor formation, and if this can be further exacerbated by obesity is unknown. Despite the synergy between Pten and Apc inactivation in epithelial cells on intestinal tumor formation, their combined role in Lgr5+-ISCs, which are the most rapidly dividing ISC population in the intestine, is unknown...
March 28, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28300875/short-term-buserelin-administration-induces-apoptosis-and-morphological-changes-in-adult-rat-testes
#4
Behnaz Khadivi, Tahmineh Peirouvi, Masumeh Zirak JavanmardI, Yousef Rasmi
PURPOSE: To investigate the effect of buserelin on gonadal structure and function in adult male rats. METHODS: Twenty-four adult Wistar male rats were divided into three groups: two treated groups and controls. The first and second treated groups received 300 (low dose) and 500 (high dose) µg/kg buserelin, respectively, and the control group received normal saline. All groups were treated subcutaneously for five days. RESULTS: The seminiferous tubular epithelial thickness was significant decreased in the treated groups compared with those in the control...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28299003/comparison-between-two-scheimpflug-anterior-segment-analyzers
#5
Alireza Baradaran-Rafii, Tahmineh Motevasseli, Forouzan Yazdizadeh, Farid Karimian, Sahba Fekri, Amir Baradaran-Rafii
PURPOSE: To compare the anterior segment indices measured by two Scheimpflug camera machines; Galilei and Pentacam. METHODS: In this observational case series, the anterior segment indices of myopic healthy subjects seeking for refractive surgery were measured by Pentacam and Galilei on the same day. Analyzed parameters were anterior and posterior best fit spheres (BFS), axial curvature, true corneal power, central corneal thickness (CCT), anterior chamber (AC) depth, AC volume, AC angle, and pupil diameter...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28298973/effect-of-different-mixing-and-placement-methods-on-the-quality-of-mta-apical-plug-in-simulated-apexification-model
#6
Negin Ghasemi, Maryam Janani, Tahmineh Razi, Faezeh Atharmoghaddam
BACKGROUND: It is necessary apical plug material to exhibit proper adaptation with the root canal walls. Presence of voids at the interface between the root canal wall and this material result in micro leakage, which might have a relationship with post treatment disease. The aim of the present study was to evaluate the effect of different mixing (manual and ultrasonic) and placement (manual and manual in association with indirect ultrasonic) method of Mineral Trioxide Aggregate (MTA) on the void count and dimension in the apical plug in natural teeth with simulated open apices...
March 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28278615/in-vitro-cholinesterase-inhibitory-activity-of-some-plants-used-in-iranian-traditional-medicine
#7
Mina Saeedi, Khatereh Babaie, Elahe Karimpour-Razkenari, Mahdi Vazirian, Tahmineh Akbarzadeh, Mahnaz Khanavi, Mannan Hajimahmoodi, Mohammad Reza Shams Ardekani
In this study, in vitro evaluation of cholinesterase inhibitory (ChEI) activity of various plants including betel nuts (Areca catechu L.), clove buds (Syzygium aromaticum L.), aerial parts of dodder (Cuscuta chinensis Lam.), common polypody rhizomes (Polypodium vulgare L.) and turpeth roots (Ipomoea turpethum R. Br.) which were recommended for the treatment of AD symptoms in Iranian Traditional Medicine (ITM) is reported. Among them, aqueous extract of A. catechu L. was found as the most potent anti-AChE (IC50 = 32...
March 6, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28202057/improvement-of-memory-and-learning-by-intracerebroventricular-microinjection-of-t3-in-rat-model-of-ischemic-brain-stroke-mediated-by-upregulation-of-bdnf-and-gdnf-in-ca1-hippocampal-region
#8
Tahmineh Mokhtari, Mohammad Akbari, Fatemeh Malek, Iraj Ragerdi Kashani, Tayebeh Rastegar, Farshid Noorbakhsh, Mahmoud Ghazi-Khansari, Fatemeh Attari, Gholamreza Hassanzadeh
BACKGROUND: Ischemic stroke is a common leading cause of death and disability with lack of effective therapies. In this study, T3 was intra-ventricularly injected to evaluate gene expression and protein concentration of and brain-derived neurotrophic factor (BDNF) and Glial cell-derived neurotrophic factor (GDNF) in hippocampal CA1 region in rat model of brain ischemia/reperfusion (I/R). METHODS: In this study, transient middle cerebral artery occlusion (tMCAo) was used as model of ischemic brain stroke...
February 15, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28139064/corneal-profile-in-primary-congenital-glaucoma
#9
Azadeh Doozandeh, Shahin Yazdani, Shabnam Ansari, Mohammad Pakravan, Tahmineh Motevasseli, Bagher Hosseini, Mehdi Yasseri
PURPOSE: To investigate biomechanical and ultrastructural corneal parameters and ocular biometrics in the affected eyes of patients with unilateral primary congenital glaucoma (PCG) as compared to unaffected fellow eyes and age-matched healthy controls. METHODS: A total of 12 patients with treated unilateral PCG and 10 normal subjects were evaluated. LENSTAR was performed to determine biometric parameters; the ocular response analyser was employed to determine biomechanical properties and slit-scanning confocal microscopy was used for evaluation of corneal ultrastucture...
January 31, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28054286/predictive-validity-and-inter-rater-reliability-of-the-persian-version-of-full-outline-of-unresponsiveness-among-unconscious-patients-with-traumatic-brain-injury-in-an-intensive-care-unit
#10
Somayeh Momenyan, Sey Mojtaba Mousavi, Tahmineh Dadkhahtehrani, Fatemeh Sarvi, Reza Heidarifar, Faezeh Kabiri, Erfan Mohebi, Mohammad Koohbor
INTRODUCTION: The Glasgow Coma Scale (GCS) has some limitations when evaluating the unconscious patient. This study aims to validate the Persian version of the FOUR (Full Outline of Unresponsiveness) score as a proposed substitute. METHODS: Two nurses, two nursing students, and two physicians scored the prepared Persian version of the FOUR and GCS in 84 patients with acute brain injury. The inter-rater agreement for the FOUR and the GCS scores was evaluated by the weighted kappa (κ w)...
January 4, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28042414/lack-of-association-between-cu-t-380a-intrauterine-device-and-secondary-infertility-in-iran
#11
Mahnaz Abdinasab, Razieh Dehghani Firouzabadi, Tahmineh Farajkhoda, Ali Mohammad Abdoli
BACKGROUND: The appropriate choice of a contraceptive method has been a major issue in reproductive health research. Cu T intrauterine device (Cu T IUD) has been introduced as one of the most effective contraceptive methods in the world, however, the relationship between prior use of Cu T IUD and secondary infertility has not been evaluated in Iran. To examine the association of Cu T-380A IUD and secondary infertility in Iran. MATERIALS AND METHODS: A retrospective cohort study was conducted from December 2010 to September 2011 in the Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran...
January 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28034286/altered-prolylcarboxypeptidase-expression-and-function-in-response-to-different-risk-factors-of-diabetes
#12
Tahmineh Tabrizian, Lillie Floyd, Zia Shariat-Madar
BACKGROUND: Prolylcarboxypeptidase (PRCP, EC:3.4.16.2) is a cardioprotective protease. Plasma PRCP levels are elevated in type 2 diabetes (T2D) mellitus and cardiovascular diseases. OBJECTIVE: Since diabetic cardiomyopathy is a late complication of uncontrolled diabetes, we tested the hypothesis that glucose and free fatty acid related risk factors for T2D mellitus and cardiovascular disease may reduce the cardioprotective property of PRCP. METHOD: 0 We examined the effects of glucose, saturated fatty acids, and unsaturated fatty acids on PRCP expression in cultured H9c2 cells as an in-vitro model for pharmacological studies...
December 29, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27914694/synthesis-of-novel-chromenones-linked-to-1-2-3-triazole-ring-system-investigation-of-biological-activities-against-alzheimer-s-disease
#13
Mina Saeedi, Maliheh Safavi, Elahe Karimpour-Razkenari, Mohammad Mahdavi, Najmeh Edraki, Farshad Homayouni Moghadam, Mahnaz Khanavi, Tahmineh Akbarzadeh
In this work, novel chromenones linked to 1,2,3-triazole ring system were synthesized and evaluated for their anti-ChE activity. Among them, N-((1-(2-chlorobenzyl)-1H-1,2,3-triazol-5-yl)methyl)-8-methoxy-2-oxo-2H-chromene-3-carboxamide (6m) showed good anti-acetylcholinesterase activity (IC50=15.42μM). Also, compound 6m demonstrated neuroprotective effect against H2O2-induced cell death in PC12 neurons, however, it showed no beta-secretase (BACE1) inhibitory activity. Docking and kinetic studies separately confirmed dual binding activity of compound 6m since it targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE...
November 24, 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/27910192/novel-tacrine-based-pyrano-3-4-5-6-pyrano-2-3-b-quinolinones-synthesis-and-cholinesterase-inhibitory-activity
#14
Roshanak Hariri, Zahra Afshar, Mohammad Mahdavi, Maliheh Safavi, Mina Saeedi, Zahra Najafi, Reyhaneh Sabourian, Elahe Karimpour-Razkenari, Najmeh Edraki, Farshad Homayouni Moghadam, Abbas Shafiee, Mahnaz Khanavi, Tahmineh Akbarzadeh
In order to develop effective anti-cholinesterase compounds, a novel series of pyrano[3',4':5,6]pyrano[2,3-b]quinolinones were designed, synthesized, and evaluated in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). All derivatives showed very good AChE inhibitory (AChEI) activity (IC50  = 0.37-5.62 μM) compared with rivastigmine (IC50  = 11.07 μM). Among them, 11-amino-12-(2,3-dichlorophenyl)-3-methyl-7,8,9,10-tetrahydropyrano[3',4':5,6]pyrano[2,3-b]quinolin-1(12H)-one (6f) displayed the best inhibitory activity...
December 2016: Archiv der Pharmazie
https://www.readbyqxmd.com/read/27878461/crimean-congo-hemorrhagic-fever-among-children-in-iran
#15
Dalileh Aslani, Mostafa Salehi-Vaziri, Vahid Baniasadi, Tahmineh Jalali, Sanam Azad-Manjiri, Tahereh Mohammadi, Sahar Khakifirouz, Mehdi Fazlalipour
Crimean-Congo hemorrhagic fever (CCHF) is a viral zoonotic disease which is endemic in Iran. The etiological agent of CCHF is an RNA virus belonging to the genus Nairovirus of the family Bunyaviridae. CCHF virus (CCHFV) can be transmitted to humans through bites from infected ticks and direct contact with infected blood or tissues. Although the disease has been observed in different age groups, the rate of disease is lower in children and elderly. This study was designed to characterize CCHFV-infected children in Iran...
March 2017: Archives of Virology
https://www.readbyqxmd.com/read/27863370/novel-tacrine-1-2-3-triazole-hybrids-in%C3%A2-vitro-in%C3%A2-vivo-biological-evaluation-and-docking-study-of-cholinesterase-inhibitors
#16
Zahra Najafi, Mohammad Mahdavi, Mina Saeedi, Elahe Karimpour-Razkenari, Raymond Asatouri, Fahimeh Vafadarnejad, Farshad Homayouni Moghadam, Mahnaz Khanavi, Mohammad Sharifzadeh, Tahmineh Akbarzadeh
A new series of tacrine-1,2,3-triazole hybrids were designed, synthesized, and evaluated as potent dual cholinesterase inhibitors. Most of synthesized compounds showed good in vitro inhibitory activities toward both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Among them, 7-chloro-N-((1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl)-1,2,3,4-tetrahydroacridin-9-amine (5l) was found to be the most potent anti-AChE derivative (IC50 = 0.521 μM) and N-((1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl)-1,2,3,4-tetrahydroacridin-9-amine (5j) demonstrated the best anti-BChE activity (IC50 = 0...
January 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27860301/synthesis-and-biological-evaluation-of-novel-imidazopyrimidin-3-amines-as-anticancer-agents
#17
Mohammad Mahdavi, Shima Dianat, Behnaz Khavari, Setareh Moghimi, Mohammad Abdollahi, Maliheh Safavi, Arash Mouradzadegun, Sussan Kabudanian Ardestani, Reyhaneh Sabourian, Saeed Emami, Tahmineh Akbarzadeh, Abbas Shafiee, Alireza Foroumadi
Groebke-Blackburn-Bienayme reaction has been utilized for the synthesis of new imidazo[1,2-a]pyrimidine derivatives as novel anticancer agents. The cytotoxic activities of compounds were evaluated against human cancer cell lines including MCF-7, T-47D, and MDA-MB-231, compared with etoposide as the standard drug. Among the tested compounds, hydroxy- and/or methoxy-phenyl derivatives (6a-c and 6k) with IC50 values of 6.72-14.36 μm were more potent than etoposide against all cell lines. The acridine orange/ethidium bromide double staining and DNA fragmentation studies demonstrated that the cytotoxic effect of 3-hydroxy-4-methoxyphenyl derivative 6c is associated with apoptosis in cancer cells...
May 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27703870/intravitreal-bevacizumab-role-in-the-treatment-of-macular-edema-secondary-to-retinal-vasoproliferative-tumor-in-a-patient-with-neurofibromatosis-type-1
#18
Ramin Nourinia, Tahmineh Motevasseli, Zahra Tofighi
Objective: To report a case of neurofibromatosis-1 (NF-1) with retinal vasoproliferative tumor (RVPT) and macular edema and exudation that was successfully treated with intravitreal bevacizumab (IVB). Method: A retrospective case report of patient with neurofibromatosis, retinal vasoproliferative tumor and macular edema who received three monthly intravitreal injections of bevacizumab. Optical coherence tomography (OCT) and fluorescein angiography (FAG) before and three months after treatment were done. Results: Macular edema and exudation of the right eye was effectively resolved with IVB injection and vascularity of RVPT significantly decreased after treatment with IVB...
2016: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/27677982/sirtinol-abrogates-late-phase-of-cardiac-ischemia-preconditioning-in-rats
#19
Fereshteh Safari, Shahnaz Shekarforoosh, Tahmineh Hashemi, Simin Namvar Aghdash, Asefeh Fekri, Fatemeh Safari
The aim of this study was to investigate the effect of sirtinol, as an inhibitor of sirtuin NAD-dependent histone deacetylases, on myocardial ischemia reperfusion injury following early and late ischemia preconditioning (IPC). Rats underwent sustained ischemia and reperfusion (IR) alone or proceeded by early or late IPC. Sirtinol (S) was administered before IPC. Arrhythmias were evaluated based on the Lambeth model. Infarct size (IS) was measured using triphenyltetrazolium chloride staining. The transcription level of antioxidant-coding genes was assessed by real-time PCR...
September 27, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27640645/medicinal-plants-used-in-iranian-traditional-medicine-itm-as-contraceptive-agents
#20
REVIEW
Reyhaneh Sabourian, Elahe Karimpour-Razkenari, Mina Saeedi, Maryam S Bagheri, Mahnaz Khanavi, Narges Sadati, Tahmineh Akbarzadeh, Mohammad R S Ardekani
BACKGROUND: In recent years, rapid population growth and unsafe abortions have emerged as controversial health issues in some countries. Hence, safe and effective contraceptive methods or agents have attracted a great deal of attention and the corresponding market has been widely expanded. OBJECTIVE: In this study, we present a review profiting from Iranian Traditional Medicine (ITM) to introduce expedient plants as efficient contraceptive agents. METHODS: Medicinal plants suggested as contraceptive agents were obtained from ITM text books and they were also investigated using search engines to confirm their in vitro and in vivo efficacy...
2016: Current Pharmaceutical Biotechnology
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