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https://www.readbyqxmd.com/read/29904634/dietary-walnuts-protect-against-obesity-driven-intestinal-stem-cell-decline-and-tumorigenesis
#1
Fangxia Guan, Tahmineh Tabrizian, Ardijana Novaj, Masako Nakanishi, Daniel W Rosenberg, Derek M Huffman
Obesity can negatively impact intestinal homeostasis, and increase colon cancer risk and related mortality. Thus, given the alarmingly high rates of obesity in the US and globally, it is critical to identify practical strategies that can break the obesity-cancer link. Walnuts have been increasingly recognized to mitigate cancer risk, and contain many bioactive constituents with antioxidant and anti-inflammatory properties that could potentially counteract pathways thought to be initiators of obesity-related cancer...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29861758/association-between-the-religious-coping-of-infertile-people-with-their-own-quality-of-life-and-their-spouses-a-correlation-study-in-iranian-infertile-couples
#2
Tahmineh Dadkhahtehrani, Somayeh Momenyan, Saeide Heidari, Narges Momenyan
Background: Infertile couples have a lower quality of life (QoL) than that of the general population. Religious coping strategies (RCOPE) could affect QoL in distressing situations. The present study aimed to assess the association between the RCOPE of infertile people with their own QoL and that of their spouses'. Materials and Methods: This cross-sectional study was conducted among 200 infertile couples referring to Infertility Center of Qom, Iran in 2015. The data was collected using three questionnaires including Brief RCOPE scale, Short Form Health Survey, and a demographic questionnaire...
May 2018: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29795991/gastrointestinal-lesions-in-african-american-patients-with-iron-deficiency-anemia
#3
Hassan Brim, Anahita Shahnazi, Mehdi Nouraie, Dilhana Badurdeen, Adeyinka O Laiyemo, Tahmineh Haidary, Ali Afsari, Hassan Ashktorab
Background: Iron deficiency anemia (IDA) is a frequent disorder that is associated with many serious diseases. However, the findings of an evaluation of IDA-associated gastrointestinal disorders are lacking among African American patients. Aim: To determine the most prevalent gastrointestinal lesions among African American patients with IDA especially in young men. Methods: We reviewed medical records (n = 422) of patients referred for evaluation of IDA from 2008 to 2012...
2018: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/29766648/synthesis-of-new-benzimidazole-1-2-3-triazole-hybrids-as-tyrosinase-inhibitors
#4
Mohammad Mahdavi, Arsalan Ashtari, Mahsima Khoshneviszadeh, Sara Ranjbar, Ameneh Dehghani, Tahmineh Akbarzadeh, Bagher Larijani, Mehdi Khoshneviszadeh, Mina Saeedi
A novel series of benzimidazole-1,2,3-triazole hybrids containing substituted benzyl moieties were designed, synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. The results indicated that 2-(4-((1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole (6g) and 2-(4-((1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole (6h) exhibited effective inhibitory activity with IC50 values of 9.42 and 10.34 μM, respectively, comparable to that of kojic acid as the reference drug (IC50 = 9...
May 15, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29753967/an-amplified-chemiluminescence-system-based-on-si-doped-carbon-dots-for-detection-of-catecholamines
#5
Mohammad Amjadi, Tooba Hallaj, Jamshid L Manzoori, Tahmineh Shahbazsaghir
We report on a chemiluminescence (CL) system based on simultaneous enhancing effect of Si-doped carbon dots (Si-CDs) and cetyltrimethylammonium bromide (CTAB) on HCO3 - -H2 O2 reaction. The possible CL mechanism is investigated and discussed. Excited-state Si-CDs was found to be the final emitting species, which are probably produced via electron and hole injection by oxy-radicals. The effect of several other heteroatom-doped CDs and undoped CDs was also investigated and compared with Si-CDs. Furthermore, it was found that catecholamines such as dopamine, adrenaline and noradrenaline remarkably diminish the CL intensity of Si-CD-HCO3 - -H2 O2 -CTAB system...
April 30, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29672178/obese-and-allergic-related-asthma-phenotypes-among-children-across-the-united-states
#6
Mindy K Ross, Tahmineh Romero, Myung S Sim, Peter G Szilagyi
OBJECTIVES: Pediatric asthma is heterogeneous with phenotypes that reflect differing underlying inflammation and pathophysiology. Little is known about the national prevalence of certain obesity and allergy related asthma phenotypes or associated characteristics. We therefore assessed the national prevalence, risk factors, and parent-reported severity of four asthma phenotypes: not-allergic-not-obese, allergic-not-obese, obese-not-allergic, and allergic-and-obese. METHODS: We analyzed data from the 2007-2008 National Survey of Children's Health (NSCH) of 10-17 year-olds with parent-reported asthma...
April 19, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29653339/natural-killer-cells-target-and-differentiate-cancer-stem-like-cells-undifferentiated-tumors-strategies-to-optimize-their-growth-and-expansion-for-effective-cancer-immunotherapy
#7
REVIEW
Kawaljit Kaur, Milica Perišić Nanut, Meng-Wei Ko, Tahmineh Safaie, Janko Kos, Anahid Jewett
Natural killer (NK) cells are known to select and differentiate cancer stem-like cells/undifferentiated tumors via lysis, and secreted/membrane bound IFN-γ and TNF-α respectively, resulting in the control of tumor growth. Several in vivo mouse models including humanized-BLT mice have been used to study the biology and significance of NK cells in selection/differentiation of stem-like tumors within the context of a reconstituted human immune system. In addition, we discuss the evidence and significance of NK cell loss at the pre-neoplastic stage...
April 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29607344/a-qualitative-approach-to-women-s-perspectives-on-exercise-in-iran
#8
Zohreh Kalani, Zahra Pourmovahed, Tahmineh Farajkhoda, Imane Bagheri
Background: It is believed that women of all ages do less physical activities compared to men. The development of interventional projects for increasing the women's participation in physical activity needs the recognition of resources and exploration of women's perspectives on exercise in their lives in the Iranian culture and context. Methods: This qualitative study was conducted in an urban area of Iran on 46 women attending healthcare centers, volunteer health care providers, university students, sportswomen and one of the officials of the provincial women's sports...
April 2018: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29605566/therapeutic-effect-of-perinatal-exogenous-melatonin-on-behavioral-and-histopathological-changes-and-antioxidative-enzymes-in-neonate-mouse-model-of-cortical-malformation
#9
Maryam Azizi, Parichehr Pasbakhsh, Seyed Alireza Nadji, Mihan Pourabdollah, Tahmineh Mokhtari, Makan Sadr, Negar Omidi, Iraj Ragerdi Kashani, Adib Zendehdel
BACKGROUND: Melatonin, which is an antioxidant and neuroprotective agent, can be an effective treatment for neurological disorders. We assessed the effect of melatonin administration on histological changes, antioxidant enzyme levels, and behavioral changes in a neonate mouse model of cortical malformation. MATERIALS AND METHODS: Cortical malformation was induced by two injections of 15 mg/kg methylazoxymethanol (MAM) on gestational day 15 (E15). Pregnant Balb/c mice were randomly divided into the following six groups: Control (CO), Melatonin (MEL), Luzindole (LUZ), MAM, MEL + MAM1 (co-treatment), and MEL + MAM2 (pretreatment)...
March 29, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29560769/expression-of-p53-bcl-2-and-bax-in-endometrial-carcinoma-endometrial-hyperplasia-and-normal-endometrium-a-histopathological-study
#10
Simin Mirakhor Samani, Tahmineh Ezazi Bojnordi, Manijeh Zarghampour, Sobhan Merat, Daniel F Fouladi
Our objective was to examine the expression rates of p53, Bcl-2 and Bax in endometrial carcinoma, endometrial hyperplasia and normal endometrium. A total of 94 endometrial frozen sections (carcinoma 48, hyperplasia 21, normal tissue 25) were examined immunohistochemically in terms of the expression rates of p53, Bcl-2 and Bax. All of the specimens in the non-malignant groups were positive for Bax, whereas this rate was 85.4% in the group with malignant specimens (p = .03). Conversely, p53 was expressed only in the cancerous group (77...
March 21, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29554047/vitamin-d-binding-protein-deficiency-in-mice-decreases-systemic-and-select-tissue-levels-of-inflammatory-cytokines-in-a-murine-model-of-acute-muscle-injury
#11
Richard R Kew, Tahmineh Tabrizian, James A Vosswinkel, James E Davis, Randeep S Jawa
BACKGROUND: Severe acute muscle injury results in massive cell damage, causing the release of actin into extracellular fluids where it complexes with the vitamin D-binding protein (DBP). We hypothesized that a systemic DBP deficiency would result in a less proinflammatory phenotype. METHODS: C57BL/6 wild-type (WT) and DBP-deficient (DBP-/-) mice received intramuscular injections of either 50% glycerol or phosphate-buffered saline into thigh muscles. Muscle injury was assessed by histology...
June 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29550386/maternal-exposure-to-silver-nanoparticles-are-associated-with-behavioral-abnormalities-in-adulthood-role-of-mitochondria-and-innate-immunity-in-developmental-toxicity
#12
Shayan Amiri, Aliakbar Yousefi-Ahmadipour, Mir-Jamal Hosseini, Arya Haj-Mirzaian, Majid Momeny, Heshmat Hosseini-Chegeni, Tahmineh Mokhtari, Sharmin Kharrazi, Gholamreza Hassanzadeh, Seyed Mohammad Amini, Somayeh Jafarinejad, Mahmoud Ghazi-Khansari
Silver nanoparticles (Ag-NPs) are currently used in a wide range of consumer products. Considering the small size of Ag-NPs, they are able to pass through variety of biological barriers and exert their effects. In this regard, the unique physicochemical properties of Ag-NPs along with its high application in the industry have raised concerns about their negative effects on human health. Therefore, it investigated whether prenatal exposure to low doses of Ag-NPs is able to induce any abnormality in the cognitive and behavioral performance of adult offspring...
May 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29471204/fabrication-of-a-solution-gated-transistor-based-on-valinomycin-modified-iron-oxide-nanoparticles-decorated-zinc-oxide-nanorods-for-potassium-detection
#13
Min-Sang Ahn, Rafiq Ahmad, Kiesar Sideeq Bhat, Jin-Young Yoo, Tahmineh Mahmoudi, Yoon-Bong Hahn
There are considerable interests to detect and monitor the abnormal level of minerals in water for avoiding/preventing any toxic effects after consumption. Herein, we report the fabrication of solution-gated field-effect-transistor (FET) based potassium sensor using iron oxide nanoparticles (Fe2 O3 NPs) modified directly grown zinc oxide nanorods (ZnO NRs). The Fe2 O3 NPs modification of ZnO NRs provided stability to nanorods surface and improved surface area for valinomycin immobilization. As-fabricated potassium sensor (valinomycin-Fe2 O3 NPs-ZnO NRs/SiO2 /Si) provided enhanced current response with increasing potassium concentration...
May 15, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29423365/exploring-the-feelings-of-iranian-women-of-reproductive-age-about-health-care-seeking-behavior-a-qualitative-study
#14
Mohammad Ali Morowatisharifabad, Tahereh Rahimi, Tahmineh Farajkhoda, Hossein Fallahzadeh, Siamak Mohebi
Background: Despite the important role of feelings in health care seeking behavior (HCSB), this subject has not yet been adequately investigated. HCSB-related feelings begin with the onset of disease symptoms and persist in different forms after treatment. The aim of current study was to explore the feelings that women of reproductive age experience when they seek health care. Methods: In this deductive, qualitative content analysis, participants were selected by purposeful sampling. Semi-structured, in-depth interviews with 17 women of reproductive age and 5 health care staffs in Qom, Iran were carried out until data saturation was achieved...
2018: Health Promotion Perspectives
https://www.readbyqxmd.com/read/29421707/design-and-synthesis-of-novel-coumarin-pyridinium-hybrids-in-vitro-cholinesterase-inhibitory-activity
#15
Fahimeh Vafadarnejad, Mohammad Mahdavi, Elahe Karimpour-Razkenari, Najmeh Edraki, Bilqees Sameem, Mahnaz Khanavi, Mina Saeedi, Tahmineh Akbarzadeh
A novel series of coumarin-pyridinium hybrids were synthesized and evaluated as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) using Ellman's method. Among synthesized compounds, 1-(3-fluorobenzyl)-4-((2-oxo-2H-chromene-3-carboxamido)methyl)pyridinium bromide (7l) was found to be the most active compound toward AChE (IC50  = 10.14 µM), 1-(3-chlorobenzyl)-3-((2-oxo-2H-chromene-3-carboxamido)methyl)pyridinium bromide (7g) and 1-(2,3-dichlorobenzyl)-3-((2-oxo-2H-chromene-3-carboxamido)methyl)pyridinium chloride (7h) depicted the best BChE inhibitory activity (IC50 s = 0...
April 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29408145/fabrication-of-sensitive-non-enzymatic-nitrite-sensor-using-silver-reduced-graphene-oxide-nanocomposite
#16
Rafiq Ahmad, Tahmineh Mahmoudi, Min-Sang Ahn, Jin-Young Yoo, Yoon-Bong Hahn
There are increasing demands of more sensitive sensors for monitoring potential hazards in real water that may cause serious problems to human health. Herein, we report the development of a non-enzymatic nitrite sensor using nanocomposite of reduced graphene oxide decorated with silver nanoparticle (Ag-rGO). First, Ag-rGO nanocomposite was synthesized using a facile and cost-effective microwave-assisted approach. Then, as-synthesized Ag-rGO nanocomposite was used to modify glassy carbon electrode (GCE) and applied for the sensitive and selective detection of nitrite in the aqueous medium with increasing concentration of nitrite...
April 15, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29403619/national-survey-of-availability-of-physical-rehabilitation-services-in-iran-a-mixed-methods-study
#17
Marzieh Shirazikhah, Arash Mirabzadeh, Homeira Sajadi, Mohammad Taghi Joghataei, Akbar Biglarian, Tahmineh Mousavi, Farahnaz Mohammadi Shahboulaghi
Background: The prevalence of disability in Iran has increased due to ageing of the population and the presence of chronic diseases. However, little is known about the availability of rehabilitation services in Iran. Objective: To study the availability of physical rehabilitation services in Iran. Methods: This was a mixed method study. In the first phase, a qualitative design was conducted for designing an instrument with focus groups based on Service Availability and Readiness Assessment (SARA) instrument (developed by World Health Organization)...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29373886/the-neuroprotective-effects-of-flaxseed-oil-supplementation-on-functional-motor-recovery-in-a-model-of-ischemic-brain-stroke-upregulation-of-bdnf-and-gdnf
#18
Abolqasem Bagheri, Sahand Talei, Negar Hassanzadeh, Tahmineh Mokhtari, Mohammad Akbari, Fatemeh Malek, Seyed Behnamedin Jameie, Yousef Sadeghi, Gholamreza Hassanzadeh
Cerebral ischemic stroke is a common leading cause of disability. Flaxseed is a richest plant-based source of antioxidants. In this study, the effects of flaxseed oil (FSO) pretreatment on functional motor recovery and gene expression and protein content of neurotrophic factors in motor cortex area in rat model of brain ischemia/reperfusion (I/R) were assessed. Transient middle cerebral artery occlusion (tMCAo) in rats was used as model brain I/R. Rats (6 in each group) were randomly divided into four groups of Control (Co+normal saline [NS]), Sham (Sh+NS), tMCAo+NS and tMCAo+FSO...
December 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29344051/experiences-of-fathers-with-inpatient-premature-neonates-phenomenological-interpretative-analysis
#19
Tahmineh Dadkhahtehrani, Narges Eskandari, Zohre Khalajinia, Hoda Ahmari-Tehran
Background: Birth and hospitalization of premature neonates create enormous challenges for the family with serious impacts on parents' mental and emotional health. The present study was designed to explore the experiences of fathers with premature neonates hospitalized in a neonatal intensive care unit (NICU). Materials and Methods: In this interpretative phenomenological study, data were collected using in-depth interviews guided with a semi-structured questionnaire and analyzed by interpretative phenomenological analysis...
January 2018: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29167715/quality-of-the-calcium-enriched-mixture-apical-plug-in-simulated-apexification-model-effect-of-different-mixing-and-placement-methods
#20
Saeed Rahimi, Negin Ghasemi, Tahmineh Razi, Akbar Rezaiepour
Background: Presence of voids at root canal wall‒apical seal material interface gives rise to the entrapment of toxins and microorganisms, which might have a relationship with post treatment disease. The present study was carried out to evaluate the effect of different mixing (manual and ultrasonic) and placement (manual and manual in association with indirect ultrasonic) methods of Calcium-enriched Mixture (CEM) cement on the number and dimensions of voids in the apical plug in simulated apexification models...
October 2017: Journal of Clinical and Experimental Dentistry
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