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https://www.readbyqxmd.com/read/29679922/the-reliability-of-gait-variability-measures-for-individuals-with-parkinson-s-disease-and-healthy-older-adults-the-effect-of-gait-speed
#1
Linda Rennie, Niklas Löfgren, Rolf Moe-Nilssen, Arve Opheim, Espen Dietrichs, Erika Franzén
BACKGROUND: Step-to-step variability is a marker of reduced motor control and a frequently studied outcome measure in neurodegenerative disorders such as Parkinson's disease (PD) as compared to healthy older adults (HOA). To challenge motor control of gait, walking should be tested at different gait speeds. Good reliability is essential, and gait variability estimates show good reproducibility when sampled at normal gait speed. The aim was therefore to investigate if gait variability could be reliably sampled at slow and fast speeds for individuals with PD and HOA by evaluating test-retest reliability...
April 14, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29679911/the-effects-of-valproate-and-topiramate-use-on-serum-insulin-leptin-neuropeptide-y-and-ghrelin-levels-in-epileptic-children
#2
Nafiye Polat Çiçek, Tülay Kamaşak, Mine Serin, Aysenur Okten, Ahmet Alver, Ali Cansu
PURPOSE: Although some drugs used in the treatment of epilepsy are known to affect body weight, the hormonal factors responsible have not been sufficiently described. The purpose of this study was to compare insulin, leptin, neuropeptide Y and ghrelin levels in children with epilepsy receiving monotherapy with topiramate (TPM) and valproic acid (VPA), the drugs whose effects on body weight have been most discussed, with those of a control group. METHOD: 48 patients (25 VPA, 23 TPM) aged between 6 and 15...
April 11, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29679898/heart-rate-variability-alterations-in-late-life-depression-a-meta-analysis
#3
REVIEW
Lydia Brown, Chandan Karmakar, Richard Gray, Ripu Jindal, Terrence Lim, Christina Bryant
OBJECTIVE: There is strong evidence for a bi-directional relationship between heart-health and depression in later life, but the physiological mechanisms underlying this relationship remain unclear. Heart rate variability is one promising factor that might help explain this relationship. We present results of a meta-analysis that considers heart rate variability alterations in older adults with depression. METHODS: Literature search of Embase, PsychInfo and Medline revealed five clinical studies and six observational studies that examined the relationship between heart rate variability and depression in adults with a mean age over 60...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29679804/cytotoxicity-of-paramagnetic-cations-loaded-polydopamine-nanoparticles
#4
Milena A Vega, Celia Nieto, Gema Marcelo, Eva M Martín Del Valle
Polydopamine (PD) is a synthetic melanin pigment of great importance in biomedicine, where its affinity for metallic cations, especially paramagnetic ions, has sparked interest in its use in the development of magnetic resonance imaging (MRI) contrast agents. In this work, we report the cytotoxicity of metal-enriched PD nanoparticles on NIH3T3, a healthy cell line and BT474, a breast cancer cell line. Remarkably, it was found that the metal- enriched PD particles (Mn+  = Fe3+ , Fe2+ and Cu2+ ) were highly cytotoxic to the breast cancer cells, even after 24 h of treatment...
April 12, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29679566/matrix-stiffness-regulate-apoptotic-cell-death-in-hiv-hcv-co-infected-hepatocytes-importance-for-liver-fibrosis-progression
#5
Murali Ganesan, Raghubendra Singh Dagur, Edward Makarov, Larisa I Poluektova, Srivatsan Kidambi, Natalia A Osna
HIV-HCV co-infection causes rapid progression of liver fibrosis. These outcomes to liver cirrhosis can be improved, but not stopped by specific antiviral therapies. Due to high significance of HIV-HCV interactions for morbidity and mortality in co-infected patients, our attention was attracted to the multi-component pathogenesis of fibrosis progression as the transition to end-stage liver disease development. In this study, we hypothesize that increased matrix stiffness enhances apoptosis in HCV-HIV-co-infected hepatocytes and that capturing of apoptotic bodies (AB) derived from these infected hepatocytes by hepatic stellate cells (HSC) drives the fibrosis progression...
April 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29679564/frequencies-and-expression-levels-of-programmed-death-ligand-1-pd-l1-in-circulating-tumor-rna-ctrna-in-various-cancer-types
#6
Toshiyuki Ishiba, Andreas-Claudius Hoffmann, Joshua Usher, Yahya Elshimali, Todd Sturdevant, Mai Dang, Yolanda Jaimes, Rama Tyagi, Ronald Gonzalez, Mary Grino, Jacek K Pinski, Afsaneh Barzi, Luis E Raez, Wilfried E Eberhardt, Dirk Theegarten, Heinz-Josef Lenz, Hiroyuki Uetake, Peter V Danenberg, Kathleen Danenberg
BACKGROUND: Precision medicine and prediction of therapeutic response requires monitoring potential biomarkers before and after treatment. Liquid biopsies provide noninvasive prognostic markers such as circulating tumor DNA and RNA. Circulating tumor RNA (ctRNA) in blood is also used to identify mutations in genes of interest, but additionally, provides information about relative expression levels of important genes. In this study, we analyzed PD-L1 expression in ctRNA isolated from various cancer types...
April 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29679553/potential-diagnostic-role-of-circulating-mirnas-in-breast-cancer-implications-on-clinicopathological-characters
#7
Menha Swellam, Hekmat M El Magdoub, Naglaa M Hassan, Mona M Hefny, Mohamed Emam Sobeih
BACKGROUND: Circulating miRNAs are stable in body fluids and resembles their levels in cancer tissue/cells. They have been expressed in many cancers among them is breast cancer. Authors aimed to investigate the expression level of three circulating oncomiRNAs (miRNA-21, miRNA-222 and miRNA-373) in serum samples as a minimally non-invasive method for early detection of breast cancer, and study their relation with clinicopathological characters. METHODS: MiRNAs expression levels were determined using quantitative real-time polymerase chain reaction (qPCR) in serum samples from three groups: primary breast cancer patients (n = 137), benign breast lesion patients (n = 60), and healthy individuals as control group (n = 38)...
April 18, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29679552/serum-retinol-binding-protein-4-and-galectin-3-binding-protein-as-novel-markers-for-postmenopausal-nonalcoholic-fatty-liver-disease
#8
Hong Cai, Sha Lu, Yueming Chen, Sayantana Das, Zheng Niu, Guangchao Zhuo, Lei Lai, Zhifen Zhang
OBJECTIVE: To investigate the differential protein expression before and after menopause in women with nonalcoholic fatty liver disease (NAFLD) and to explore novel markers for menopausal NAFLD. METHODS: Eight serum samples collected from pre- or post-menopausal women with NAFLD were analysed by iTRAQ 2D-LC-MS/MS. Two protein candidates were selected and verified by enzyme-linked immunosorbent assay (ELISA) in serum samples collected from a one hundred and fifty-three female population subsequently, including 51 in post-menopausal status with NAFLD, 41 in pre-menopausal with NAFLD, 19 healthy individuals in post-menopausal status and 42 healthy pre-menopausal women...
April 18, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29679546/lithium-chloride-licl-induced-autophagy-and-downregulated-expression-of-transforming-growth-factor-%C3%AE-induced-protein-tgfbi-in-granular-corneal-dystrophy
#9
Danyao Nie, Yun Peng, Ming Li, Xinhua Liu, Meilan Zhu, Lin Ye
This study evaluated whether lithium chloride (LiCl) prevents cytoplasmic accumulation of mutant-transforming growth factor β-induced protein (Mut-TGFBI) in granular corneal dystrophy (GCD) via activation of the autophagy pathway. Levels of TGFBI and microtubule-associated protein 1A/1B-light chain 3 (LC3) in 3 GCD patients and healthy controls were analyzed by immunohistochemistry (IHC) staining and Western blot. Primary corneal fibroblasts were isolated and transfected with wild type or mutant type TGFBI over-expressed vectors, and then treated with LiCl and/or autophagy inhibitor 3-methyladenine (3-MA)...
April 18, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29679522/oropharyngeal-squamous-cell-carcinoma-induces-an-innate-systemic-inflammation-affected-by-the-size-of-the-tumor-and-the-lymph-node-spread
#10
Åsa Kågedal, Camilla Rydberg Millrud, Valtteri Häyry, Susanna Kumlien Georén, Mats Lidegran, Eva Munck-Wikland, Lars Olaf Cardell
OBJECTIVES: Inflammation is known to be associated with the progression of cancer. The study was designed to characterize the systemic inflammation in patients with oropharyngeal squamous cell carcinoma (OPSCC) and investigate its relation to tumor size, ability to metastasize and HPV status. MATERIALS AND METHODS: Blood was obtained from 58 patients with OPSCC and 90 healthy controls and analyzed with leukocyte differential count. RESULTS: The OPSCC patients displayed an increased number of neutrophils and monocytes, whereas the lymphocytes were suppressed compared to the healthy controls...
April 21, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29679458/no-evidence-for-long-term-carrier-status-of-pigs-after-african-swine-fever-virus-infection
#11
A Petrov, J H Forth, L Zani, M Beer, S Blome
This study targeted the assessment of a potential African swine fever virus (ASFV) carrier state of 30 pigs in total which were allowed to recover from infection with ASFV "Netherlands'86" prior exposure to six healthy sentinel pigs for more than 2 months. Throughout the whole trial, blood and swab samples were subjected to routine virological and serological investigations. At the end of the trial, necropsy of all animals was performed and viral persistence and distribution were assessed. Upon infection, a wide range of clinical and pathomorphological signs were observed...
April 20, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29679417/a-probiotic-modulates-the-microbiome-and-immunity-in-multiple-sclerosis
#12
Stephanie K Tankou, Keren Regev, Brian C Healy, Emily Tjon, Luca Laghi, Laura M Cox, Pia Kivisäkk, Isabelle V Pierre, Hrishikesh Lokhande, Roopali Gandhi, Sandra Cook, Bonnie Glanz, James Stankiewicz, Howard L Weiner
OBJECTIVE: Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing-remitting multiple sclerosis (RRMS) patients. METHODS: MS patients (N=9) and controls (N=13) were orally administered a probiotic containing Lactobacillus, Bifidobacterium and Streptococcus twice daily for two months. Blood and stool specimens were collected at baseline, after completion of the 2-month treatment, and 3 months after discontinuation of therapy...
April 20, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29679407/longitudinal-urinary-metabolomic-profiling-reveals-metabolites-for-asthma-development-in-early-childhood
#13
Chih-Yung Chiu, Gigin Lin, Mei-Ling Cheng, Meng-Han Chiang, Ming-Han Tsai, Kuan-Wen Su, Man-Chin Hua, Sui-Ling Liao, Shen-Hao Lai, Tsung-Chieh Yao, Kuo-Wei Yeh, Jing-Long Huang
BACKGROUND: Several metabolites and altered metabolic pathways have been reported to be associated with asthma. However, longitudinal analysis of the dynamics of metabolites contributing to the development of asthma has not yet been fully clarified. METHODS: We sought to identify the metabolic mechanisms underlying asthma development in early childhood. Thirty children with asthma and paired healthy controls from a prospective birth cohort were enrolled. Time-series analysis of urinary metabolites collected at ages 1, 2, 3, and 4 years were assessed using 1 H-nuclear magnetic resonance (NMR) spectroscopy coupled with partial least-squares discriminant analysis (PLS-DA)...
April 21, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29679395/placental-adaptations-to-micronutrient-dysregulation-in-the-programming-of-chronic-disease
#14
Pierre Hofstee, Daniel McKeating, Anthony V Perkins, James S M Cuffe
Poor nutrition during pregnancy is known to impair foetal development and increase the risk of chronic disease in offspring. Both macronutrients and micronutrients are required for a healthy pregnancy although significantly less is understood about the role of micronutrients in the programming of chronic disease. This is despite the fact that modern calorie rich diets are often also deficient in key micronutrients. The importance of micronutrients in gestational disorders is clearly understood but how they impact long term disease in humans requires further investigation...
April 21, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29679349/timeline-bioavailability-of-magnesium-compounds-in-hours-which-magnesium-compound-works-best
#15
Nazan Uysal, Servet Kizildag, Zeynep Yuce, Guven Guvendi, Sevim Kandis, Basar Koc, Aslı Karakilic, Ulas M Camsari, Mehmet Ates
Magnesium is an element of great importance functioning because of its association with many cellular physiological functions. The magnesium content of foods is gradually decreasing due to food processing, and magnesium supplementation for healthy living has become increasingly popular. However, data is very limited on the bioavailability of various magnesium preparations. The aim of this study is to investigate the bioavailability of five different magnesium compounds (magnesium sulfate, magnesium oxide, magnesium acetyl taurate, magnesium citrate, and magnesium malate) in different tissues...
April 21, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29679285/exploration-of-phyllanthus-acidus-mediated-silver-nanoparticles-and-its-activity-against-infectious-bacterial-pathogen
#16
Cherukuri Sowmya, Vuppalapati Lavakumar, Narayanan Venkateshan, Velayutham Ravichandiran, D V R Saigopal
In our present investigation, synthesis of nontoxic, eco friendly and cost effective silver nanoparticles, Phyllanthus acidus (P. acidus) was used as starting material. The influence of phyto-constituents present in aqueous extracts of Phyllanthus acidus was found to be effective in reduction of silver nitrate to free silver nanoparticles (PA-AgNPs). HPTLC finger print analysis reveals the presence of flavonoid, quercetin in aqueous extracts of Phyllanthus acidus. Surface plasmon racemonance exhibited λ max at 462 nm through UV-Vis spectroscopy...
April 20, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29679256/biomechanical-features-of-six-design-of-the-delta-external-fixator-for-treating-pilon-fracture-a-finite-element-study
#17
Muhammad Hanif Ramlee, Mohd Ayub Sulong, Evelyn Garcia-Nieto, Daniel Angure Penaranda, Antonio Ros Felip, Mohammed Rafiq Abdul Kadir
Pilon fractures can be caused by high-energy vertical forces which may result in long-term patient immobilization. Many experts in orthopedic surgery recommend the use of a Delta external fixator for type III Pilon fracture treatment. This device can promote immediate healing of fractured bone, minimizing the rate of complications as well as allowing early mobilization. The characteristics of different types of the Delta frame have not been demonstrated yet. By using the finite element method, this study was conducted to determine the biomechanical characteristics of six different configurations (Model 1 until Model 6)...
April 21, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29679246/reliability-of-tensiomyography-and-myotonometry-in-detecting-mechanical-and-contractile-characteristics-of-the-lumbar-erector-spinae-in-healthy-volunteers
#18
Christine Lohr, Klaus-Michael Braumann, Ruediger Reer, Jan Schroeder, Tobias Schmidt
PURPOSE: Tensiomyography™ (TMG) and MyotonPRO® (MMT) are two non-invasive devices for monitoring muscle contractile and mechanical characteristics. This study aimed to evaluate the test-retest reliability of TMG and MMT parameters for measuring (TMG:) muscle displacement (Dm ), contraction time (Tc ), and velocity (Vc ) and (MMT:) frequency (F), stiffness (S), and decrement (D) of the erector spinae muscles (ES) in healthy adults. A particular focus was set on the establishment of reliability measures for the previously barely evaluated secondary TMG parameter Vc ...
April 20, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29679230/dental-bleaching-on-teeth-submitted-to-enamel-microabrasion-30-years-ago-a-case-report-of-patients-compliance-during-bleaching-treatment
#19
Daniel Sundfeld, Caio Cesar Pavani, Timm Cornelius Schott, Lucas Silveira Machado, Núbia Inocêncya Pavesi Pini, André Pinheiro de Magalhães Bertoz, Renato Herman Sundfeld
OBJECTIVES: The present dental bleaching case report describes a new method that precisely quantifies the daily wearing-times of the bleaching product by inserting a microsensor in the acetate custom tray. The bleaching efficacy was also discussed since the patient was previously submitted to enamel microabrasion. METHODS: The patient was submitted to enamel microabrasion in 1987, and bleaching treatment was performed in 2005. In 2017, re-bleaching was executed using 10% peroxide carbamide...
April 20, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29679167/hot-joints-myth-or-reality-a-thermographic-joint-assessment-of-inflammatory-arthritis-patients
#20
Britney Jones, Imran Hassan, Ross T Tsuyuki, Marla Francisca Dos Santos, A S Russell, Elaine Yacyshyn
Rheumatoid arthritis is a common inflammatory disease that causes destruction of joints. Accurate recognition of active disease has significant implications in determining appropriate treatment; however, there is significant inter-rater variability in clinical joint assessment. This study aimed to assess the utility of thermographic imaging in the evaluation of inflammatory arthritis activity as an adjunct to clinical assessment. This was a cross-sectional study of 79 subjects recruited from the University of Alberta Outpatient Rheumatology clinic comparing the hand joints of 49 patients with rheumatoid arthritis (RA) diagnosed by American College of Rheumatology (ACR) criteria to 30 healthy volunteers...
April 20, 2018: Clinical Rheumatology
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