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https://www.readbyqxmd.com/read/28532106/hydrogel-loaded-with-self-assembled-dextran-sulfate-doxorubicin-complexes-as-a-delivery-system-for-chemotherapy
#1
Xiaoyun Niu, Zhiling Zhang, Yinghui Zhong
Standard clinical care for breast cancer includes lumpectomy followed by localized radiotherapy or chemotherapy. However, both therapies cause loss of normal, healthy tissue in addition to tumor tissue, leading to undesirable side effects. In this study, we found that low dose and prolonged treatment with anticancer drug doxorubicin (DOX) can completely eliminate MDA-MB-231 breast cancer cells with low cytotoxicity to NIH 3T3 fibroblasts. We further developed a novel biomaterial-based drug delivery system for controlled and sustained release of low doses of DOX based on self-assembled dextran sulfate (DS)-DOX complexes...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531844/development-of-an-uplc-ms-ms-method-for-simultaneous-quantitation-of-11-d-amino-acids-in-different-regions-of-rat-brain-application-to-a-study-on-the-associations-of-d-amino-acid-concentration-changes-and-alzheimer-s-disease
#2
Zhe Li, Yuping Xing, Xingjie Guo, Yan Cui
There are significant differences in d-amino acid concentrations between healthy people and Alzheimer's disease patients. In order to investigate the potential correlation between d-amino acids and Alzheimer's disease, a simple and sensitive ultra high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed. The method was applied to simultaneous determination of 11 d-amino acids in different regions of rat brain. Rat brain homogenates were firstly pretreated with protein precipitation procedure and then derivatized with (S)-N-(4-nitrophenoxycarbonyl) phenylalanine methoxyethyl ester [(S)-NIFE]...
May 11, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28531802/anti-inflammatory-and-antioxidant-effect-of-cerium-dioxide-nanoparticles-immobilized-on-the-surface-of-silica-nanoparticles-in-rat-experimental-pneumonia
#3
Z Serebrovska, R J Swanson, V Portnichenko, A Shysh, S Pavlovich, L Tumanovska, A Dorovskych, V Lysenko, V Tertykh, Y Bolbukh, V Dosenko
A massage with the potent counter-inflammatory material, cerium dioxide nanoparticles, is promising and the antioxidant properties of CeO2 are considered the main, if not the only, mechanism of this action. Nevertheless, the elimination of ceria nano-particles from the organism is very slow and there is a strong concern for toxic effect of ceria due to its accumulation. To overcome this problem, we engineered a combined material in which cerium nanoparticles were immobilized on the surface of silica nanoparticles (CeO2 NP), which is shown to be easily removed from an organism and could be used as carriers for nano-ceria...
May 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28531790/an-initial-evaluation-of-newly-proposed-biomarker-of-zinc-status-in-humans-linoleic-acid-dihomo-%C3%AE-linolenic-acid-la-dgla-ratio
#4
Marija Knez, James C R Stangoulis, Manja Zec, Jasmina Debeljak-Martacic, Zoran Pavlovic, Mirjana Gurinovic, Maria Glibetic
BACKGROUND: Zinc is an essential micronutrient for humans with important physiological functions. A sensitive and specific biomarker for assessing Zn status is still needed. OBJECTIVE: The major aim of this study was to examine if the changes in the content of plasma phospholipid LA, DGLA and LA: DGLA ratio can be used to efficiently predict the dietary Zn intake and plasma Zn status of humans. METHODS: The study was performed on healthy human volunteers, 25-55 years of age...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531780/vitamin-d-status-and-the-effects-of-oral-vitamin-d-treatment-in-children-with-vitiligo-a-prospective-study
#5
Gülay Karagüzel, Nil P Sakarya, Sevgi Bahadır, Selçuk Yaman, Ayşenur Ökten
BACKGROUND & AIMS: Vitiligo is a pigmentary disorder and autoimmune pathogenesis seems most likely. Decreased vitamin D levels have been related to several autoimmune diseases. Little is known about the association of vitiligo and vitamin D. We aimed to evaluate serum 25-hydroxyvitamin D [25(OH)D] levels in children with vitiligo and to determine the efficacy of oral vitamin D therapy on the repigmentation of vitamin D deficient patients. METHODS: Thirty patients aged 6-17 years with vitiligo and 30 sex- and age-matched apparently healthy controls were included in this prospective study...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531764/disrupted-resting-brain-graph-measures-in-individuals-at-high-risk-for-alcoholism
#6
Bharath Holla, Rajanikant Panda, Ganesan Venkatasubramanian, Bharat Biswal, Rose Dawn Bharath, Vivek Benegal
Familial susceptibility to alcoholism is likely to be linked to the externalizing diathesis seen in high-risk offspring from high-density alcohol use disorder (AUD) families. The present study aimed at comparing resting brain functional connectivity and their association with externalizing symptoms and alcoholism familial density in 40 substance-naive high-risk (HR) male offspring from high-density AUD families and 30 matched healthy low-risk (LR) males without a family history of substance dependence using graph theory-based network analysis...
May 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28531561/a-meta-analysis-of-neurocognition-in-youth-with-familial-high-risk-for-bipolar-disorder
#7
E Bora, A Özerdem
OBJECTIVE: Neuropsychological impairment, including deficits in social cognition is evident in subjects at genetic high-risk for psychosis. However, findings in youth at genetic risk to bipolar disorder (BP) have been suggested to be less supportive of premorbid deficits. We aimed to conduct a meta-analysis of cognitive deficits in youth with familiar risk for bipolar disorder (FHR-BD). METHODS: A novel meta-analysis of FHR-BD (mean age 10-25), including 18 studies (786 offsprings/siblings of patients with BD and 794 healthy controls), was conducted...
March 3, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28531455/effect-of-serving-size-and-addition-of-sugar-on-the-glycemic-response-elicited-by-oatmeal-a-randomized-cross-over-study
#8
Thomas M S Wolever, B Jan-Willem van Klinken, Susan E Spruill, Alexandra L Jenkins, YiFang Chu, Laura Harkness
BACKGROUND & AIMS: We aimed to determine the impact of serving size and addition of sucrose on the glycemic response elicited by oatmeal. METHODS: We studied 38 healthy subjects (mean ± SD age 40 ± 12 yr, BMI 26.4 ± 3.6 kg/m(2)) on 8 separate days using a randomized, cross-over design. Capillary blood-glucose responses over 2hr after consuming 30, 40 and 60 g Classic Quaker Quick Oats (18, 24 and 36 g available-carbohydrate [avCHO], respectively) and 30 g Oats plus 9 g sucrose (27 g avCHO) were compared with those after avCHO-matched servings of Cream of Rice cereal (Control) (22, 29, 44 and 33 g cereal, respectively)...
December 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531307/following-instructions-in-patients-with-schizophrenia-the-benefits-of-actions-at-encoding-and-recall
#9
Simon S Y Lui, Tian-Xiao Yang, Chris L Y Ng, Peony T Y Wong, Jessica O Y Wong, Ulrich Ettinger, Eric F C Cheung, Raymond C K Chan
The ability to follow spoken instructions is important to everyday functioning but has seldom been studied in patients with schizophrenia (SZ). Recent evidence suggests that action-based processing may facilitate the ability to follow instructions, which relies largely on working memory. In this study, we tested the hypothesis that SZ patients may also benefit from action-based advantages in following instructions. Forty-eight clinically stable SZ patients and 48 demographic- and IQ-matched controls completed a following spoken instruction span task involving varied encoding and recall conditions...
May 22, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28531140/a-cuffless-blood-pressure-measurement-based-on-the-impedance-plethysmography-technique
#10
Shing-Hong Liu, Da-Chuan Cheng, Chun-Hung Su
In the last decade, cuffless blood pressure measurement technology has been widely studied because it could be applied to a wearable apparatus. Electrocardiography (ECG), photo-plethysmography (PPG), and phonocardiography are always used to detect the pulse transit time (PTT) because the changed tendencies of the PTT and blood pressure have a negative relationship. In this study, the PPG signal was replaced by the impedance plethysmography (IPG) signal and was used to detect the PTT. The placement and direction of the electrode array for the IPG measurement were discussed...
May 21, 2017: Sensors
https://www.readbyqxmd.com/read/28530644/intestinal-fungi-contribute-to-development-of-alcoholic-liver-disease
#11
An-Ming Yang, Tatsuo Inamine, Katrin Hochrath, Peng Chen, Lirui Wang, Cristina Llorente, Sena Bluemel, Phillipp Hartmann, Jun Xu, Yukinori Koyama, Tatiana Kisseleva, Manolito G Torralba, Kelvin Moncera, Karen Beeri, Chien-Sheng Chen, Kim Freese, Claus Hellerbrand, Serene Ml Lee, Hal M Hoffman, Wajahat Z Mehal, Guadalupe Garcia-Tsao, Ece A Mutlu, Ali Keshavarzian, Gordon D Brown, Samuel B Ho, Ramon Bataller, Peter Stärkel, Derrick E Fouts, Bernd Schnabl
Chronic liver disease with cirrhosis is the 12th leading cause of death in the United States, and alcoholic liver disease accounts for approximately half of all cirrhosis deaths. Chronic alcohol consumption is associated with intestinal bacterial dysbiosis, yet we understand little about the contribution of intestinal fungi, or mycobiota, to alcoholic liver disease. Here we have demonstrated that chronic alcohol administration increases mycobiota populations and translocation of fungal β-glucan into systemic circulation in mice...
May 22, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28530641/the-many-ways-of-osteoclast-activation
#12
Joseph Lorenzo
Osteoclasts are the cells responsible for bone resorption, a process that is essential for the maintenance of healthy bones. Bone diseases, such as osteoporosis, which are characterized by high rates of bone resorption and loss of bone mass, may benefit from treatments that inhibit osteoclast formation and/or function. The RANKL/RANK pathway is critical for both osteoclast formation and function, and these effects are thought to be mediated by the transcription factor nuclear factor of activated T cells, cytoplasmic 1 (NFATc1)...
May 22, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28530617/-principles-of-urinary-tract-reconstructive-surgery
#13
Juan Gomez Rivas, Jesús Cisneros Ledo
INTRODUCTION: In the last 15 years, the role of laparoscopic surgery has progressively increased to include reconstructive procedures such as pyeloplasty and management of ureteral stricture, in addition to being a field in continuous development, this refers to the improvement of ergonomics, new instruments and new techniques. We present a review on basic features of laparoscopic reconstructive surgery in urology. ACQUISITION OF EVIDENCE: For this review, an exhaustive literature search was performed in PUBMED, MEDILNE, BioMed central and others, with the keywords: reconstructive surgery, urology, laparoscopy...
May 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28530614/effect-of-traditional-chinese-cooking-methods-on-fatty-acid-profiles-of-vegetable-oils
#14
Yamin Cui, Pengfei Hao, Bingjie Liu, Xianghong Meng
The effect of four frying processes (vegetable salad, stir frying, pan frying, and deep frying) on fatty acid composition of ten vegetable oils (peanut oil, soybean oil, rapeseed oil, corn oil, sunflower seed oil, rice bran oil, olive oil, sesame oil, linseed oil, and peony seed oil) was investigated using GC-MS. The result showed that trans-fatty acid (TFA) was produced during all processes. Rapeseed oil had the highest TFA content in vegetable salad oil with 2.88% of total fatty acid. The TFA content of sunflower seed oil was 0...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28530520/cardiovascular-disease-and-gout-real-world-experience-evaluating-patient-characteristics-treatment-patterns-and-health-care-utilization
#15
Michael H Pillinger, Sripal Bangalore, Alyssa B Klein, Scott Baumgartner, Robert Morlock
BACKGROUND: Gout, hyperuricemia, and cardiovascular disease (CVD) are prevalent conditions in the United States, and while they share common risk factors such as obesity, hypertension, hypercholesterolemia, and type 2 diabetes mellitus, relatively little is known about what patient and disease characteristics may link CVD with hyperuricemia and gout and how the presence of both diseases affects management decisions differently than for patients with gout alone. OBJECTIVE: To identify differences in patient characteristics, patterns of urate-lowering therapy (ULT) use, and gout control in gout patients with and without cardiovascular comorbidity...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28530503/comparison-of-self-selected-walking-speeds-and-walking-speed-variability-when-data-are-collected-during-repeated-discrete-trials-and-during-continuous-walking
#16
Marcus J Brown, Laura A Hutchinson, Michael J Rainbow, Kevin J Deluzio, Alan R De Asha
A typical gait analysis data collection consists of a series of discrete trials, where a participant initiates gait, walks through a motion capture volume, and then terminates gait. This is not a normal 'everyday' gait pattern, yet measurements are considered representative of normal walking. However, walking speed, a global descriptor of gait quality that can affect joint kinematics and kinetics, may be different during discrete trials, compared to continuous walking. Therefore, the purpose of this study was to investigate the effect of continuous walking versus discrete trials on walking speed and walking speed variability...
May 22, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28530466/angiotensin-type-1-receptor-a1166c-polymorphism-and-systemic-lupus-erythematosus-correlation-with-cellular-immunity-and-oxidative-stress-markers
#17
H Baniamerian, F Bahrehmand, A Vaisi-Raygani, Z Rahimi, T Pourmotabbed
Angiotensin II, one of the rennin-angiotensin system components, is important in the cardiovascular hemodynamic and plays an important role in the development of cardiovascular disease in systemic lupus erythematosus (SLE) patients. The angiotensin II, through interaction with angiotensin II type 1 receptor (AGTR1), promotes proliferation, inflammation and fibrosis. The single nucleotide polymorphism of the AGTR1 (dbSNP: rs5186) gene can be associated with development and progression of SLE disease. The aims of this study were to compare the frequency of AGTR1 rs5186 in SLE patients with healthy individuals and to evaluate possible association between AGTR1 A1166C gene polymorphism and serum level of lipids, neopterin and malondialdehyde in SLE patients from a population of West Iran...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28530461/increase-in-leg-stiffness-reduces-joint-work-during-backpack-carriage-running-at-slow-velocities
#18
Bernard Liew, Kevin Netto, Susan Morris
Optimal tuning of leg stiffness has been associated with better running economy. Running with load is energetically expensive, which could have a significant impact on athletic performance where backpack carriage is involved. The purpose of this study was to investigate the impact of load magnitude and velocity on leg stiffness. We also explored the relationship between leg stiffness and running joint work. Thirty-one healthy participants ran overground at three velocities (3.0, 4.0, 5.0 m.s(-1)), whilst carrying three load magnitude (0%, 10%, 20% weight)...
May 22, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28530454/-hungarian-diet-and-nutritional-status-survey-the-otap2014-study-iv-microelement-intake-of-the-hungarian-population
#19
Barbara Nagy, Zsuzsanna Nagy-Lőrincz, Márta Bakacs, Éva Illés, Eszter Sarkadi Nagy, Gergő Erdei, Éva Martos
INTRODUCTION AND AIM: The Hungarian Diet and Nutritional Status Survey examined the dietary habits of the Hungarian population. This publication presents the microelement intake. METHOD: The survey represents the microelement intake of the Hungarian non-institutionalised adult population of 18 years and older. RESULTS: While the intake of iron, copper and manganese corresponded with the recommendations in males, in females it was insufficient...
May 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28530263/utricular-hypofunction-in-patients-with-type-2-diabetes-mellitus
#20
K Jáuregui-Renaud, C Aranda-Moreno, A Herrera-Rangel
The aim of this study was to assess the function of the utricle and horizontal semicircular canals in patients with type 2 diabetes mellitus receiving primary health care, with/without a history of falls. 101 patients with type 2 diabetes mellitus, 34 to 84 years old (26 with and 75 without a history of falls) and 51 healthy volunteers (40-83 years old) accepted to participate. They denied having a history of dizziness, vertigo, unsteadiness, hearing loss or neurological disorders. None of them were seeking care due to sensory or balance decline...
May 22, 2017: Acta Otorhinolaryngologica Italica
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