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https://www.readbyqxmd.com/read/29334271/the-safety-of-available-treatments-of-male-hypogonadism-in-organic-and-functional-hypogonadism
#1
G Corona, G Rastrelli, Y Reisman, A Sforza, M Maggi
In the case of primary male hypogonadism (HG), only testosterone (T) replacement therapy (TRT) is possible whereas when the problem is secondary to a pituitary or hypothalamus alteration both T production and fertility can be, theoretically, restored. We here systematically reviewed and discussed the advantages and limits of medications formally approved for the treatment of HG. Areas covered: Data derived from available meta-analyses of placebo controlled randomized trials (RCTs) were considered and analyzed...
January 15, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29334200/comparative-effectiveness-of-antidepressant-medication-versus-psychological-intervention-on-depression-symptoms-in-women-with-infertility-and-sexual-dysfunction
#2
Hajar Pasha, Zahra Basirat, Mahbobeh Faramarzi, Farzan Kheirkhah
Background: Fertility loss is considered as a challenging experience. This study was conducted to compare the effectiveness of antidepressant medication and psychological intervention on depression symptoms in women with infertility and sexual dysfunctions (SD). MATERIALS AND METHODS: This randomized, controlled clinical trial study was completed from December 2014 to June 2015 in Babol, Iran. Of the 485 participants, 93 were randomly assigned in a 1:1:1 ratio to psychosexual therapy (PST), bupropion extended-release (BUP ER) at a dose of 150 mg/d, and control (no intervention) groups...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29327442/transplantation-or-rurality-migration-and-hiv-risk-among-chinese-men-who-have-sex-with-men-in-the-urban-areas
#3
Chuncheng Liu, Rong Fu, Weiming Tang, Bolin Cao, Stephen W Pan, Chongyi Wei, Joseph D Tucker, M Kumi Smith
INTRODUCTION: Migration of men who have sex with men (MSM) from rural to urban areas is common across low- and middle-income countries and is widely believed to contribute to elevated HIV risk among migrant MSM in urban areas. Little consensus exists on whether their risk is due to their transplantation or their being from resource-constrained rural areas. This study seeks to clarify the relationship between migration and HIV risks by comparing differences in HIV-related risky sexual behaviours and healthcare utilization across competing conceptualizations of migratory statuses...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29325456/dual-purpose-vardenafil-hydrochloride-dapoxetine-hydrochloride-orodispersible-tablets-in-vitro-formulation-evaluation-stability-study-and-in-vivo-comparative-pharmacokinetic-study-in-healthy-human-subjects
#4
Khaled El-Refaie, Mahmoud H Teaima, Mohamed A El-Nabarawi
Erectile Dysfunction (ED) is the most important disorder after premature ejaculation for sexual activity in men. Vardenafil Hydrochloride (VH) is an oral therapy for the treatment of erectile dysfunction. VH oral disintegrating tablets (ODTs) have been prepared by freeze drying technique to improve its dissolution profile and the overall clinical performance. Dapoxetine Hydrochloride (DH) was added to the best three formulae of the prepared VH ODTs to treat premature ejaculation. All the ODTs formulae were evaluated for weight variation, friability, drug content, in-vitro disintegration time, wetting time, and the dissolution study...
January 11, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29319919/outcomes-and-toxicities-in-intermediate-risk-prostate-cancer-patients-treated-with-brachytherapy-alone-or-brachytherapy-and-supplemental-external-beam-radiation-therapy
#5
Emily Schlussel Markovic, Michael Buckstein, Nelson N Stone, Richard G Stock
OBJECTIVE: To evaluate the cancer control outcomes and long-term treatment-related morbidity of brachytherapy as well as combination brachytherapy and EBRT in patients with intermediate-risk prostate cancer. MATERIALS AND METHODS: A retrospective review was conducted in a prospectively collected database of patients with intermediate-risk prostate cancer who were treated either with brachytherapy or brachytherapy and EBRT, with or without ADT, from 1990-2014. Urinary and erectile dysfunction symptoms are measured using the International Prostate Symptom Score (IPSS) and the Mount Sinai erectile function scale, and the Sexual Health Inventory for Men (SHIM), respectively...
January 10, 2018: BJU International
https://www.readbyqxmd.com/read/29319720/depression-and-adherence-to-antiretroviral-treatment-in-hiv-positive-men-in-s%C3%A3-o-paulo-the-largest-city-in-south-america-social-and-psychological-implications
#6
Ricardo Pereira de Moraes, Jorge Casseb
OBJECTIVES: The aim of the present study was to investigate the prevalence of depression and adherence to antiretroviral treatment in two groups of individuals: men who have sex with men (MSM) and men who have sex with women (MSW). METHODS: Two hundred and sixteen participants (MSM=116; MSW=100) who visited the Clinics Hospital of the School of the Medicine of the University of São Paulo completed two independent surveys (the BECK Depression Inventory and an adherence self-declared questionnaire) to evaluate their depression status and adherence to antiretroviral treatment, respectively...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319591/zika-virus-infection-in-the-pregnant-woman
#7
Meghan Holtzman, William C Golden, Jeanne S Sheffield
Zika virus is a single-stranded RNA virus from the Flaviviridae family. Transmission is typically from the bite of an infected mosquito though mother-to-child, sexual and blood donation transmissions can occur. Although maternal symptoms are uncommon and rarely severe, the consequences of congenital infections are devastating. The emergence of congenital Zika syndrome is a world-wide public health crisis. The Centers for Disease Control and Prevention, ACOG, and SMFM have developed algorithms for screening and managing women exposure to and diagnosed with Zika virus infection...
January 9, 2018: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29319511/study-of-patterns-and-markers-of-human-immune-deficiency-virus-1-hiv-1-progression-and-unemployment-rate-among-patients-from-alexandria-egypt
#8
Faika M Ghoneim, May M Raouf, Noha S Elshaer, Sarah M Abdelhamid, Reem A Noor Eldeen
Middle East and North Africa (MENA) new HIV cases show the highest increase among all regions in the world. Even though Egypt has a low prevalence among the general population (< 0.02%), a national HIV epidemic occurs in certain population risk groups. The current study was conducted to asses clinical and immunological disease progression; following up viral load (VL) and detecting delta-32 CCR5 genotype polymorphism in selected cases, determining unemployment rate and identify predictors of employment for HIV-cases...
December 4, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29319398/sexual-health-issues-for-the-young-adult-with-cancer-an-international-symposium-held-during-the-first-global-adolescents-and-young-adults-cancer-congress-edinburgh-united-kingdom
#9
Laura Mitchell, Jeremy Lewin, Julia Dirks, Kate Wang, Seline Tam, Anne Katz, Beth McCann, Kirk Lo, Valerie Laurence, Christine Rousset-Jablonski, Abha A Gupta
Sexual health is an important consideration for young adults with cancer; however, oncology healthcare providers are often not equipped with strategies to approach these problems in a systematic way. To address this gap in adolescents and young adults (AYA) care, a one-day international Sexual Health Symposium was held before the Global AYA Cancer Congress (Edinburgh, December 2016). The goals of the symposium were to (1) provide a forum, where international AYA experts had the opportunity to share their knowledge regarding AYA sexual health and (2) develop a guideline for healthcare professionals to screen for and intervene on sexual health issues...
January 10, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29319127/sexual-function-and-depressive-symptoms-in-young-men-with-hypothyroidism-receiving-levothyroxine-liothyronine-combination-therapy
#10
Robert Krysiak, Bogdan Marek, Bogusław Okopień
INTRODUCTION: Both overt and subclinical hypothyroidism are often accompanied by sexual dysfunction. Despite improving male sexual functioning, levothyroxine treatment does not always restore all its aspects. The aim of this study was to compare male sexual functioning and depressive symptoms between men with hypothyroidism receiving levothyroxine/liothyronine combination therapy and men receiving levothyroxine alone. MATERIAL AND METHODS: The study population consisted of 21 young levothyroxine-treated men with clinical symptoms of hypothyroidism in whom serum thyrotropin and thyroid hormone levels were within the normal limits...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29316814/biology-of-the-adrenal-gland-cortex-obviates-effective-use-of-adeno-associated-virus-vectors-to-treat-hereditary-adrenal-disorders
#11
Sandra Markmann, Bishnu P De, Jasmine Reid, Clarisse Jose, Jonathan B Rosenberg, Philip Leopold, Stephen M Kaminsky, Dolan Sondhi, Odelya E Pagovich, Ronald G Crystal
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder occurring in 1:10,000-1:20,000 live births. In >95% of the cases, CAH results from mutations in the CYP21A2 gene, encoding the adrenal steroid enzyme 21-hydroxylase (21OH). Cardinal phenotypic features of CAH include genital ambiguity and sexual precocity, and in severe cases, neonatal salt loss and death. Current standard of care consists of life-long oral steroid replacement to reverse the cortisol deficiency. Although significant advances in the treatment of CAH have been made, the burden of a life-long therapeutic intervention is not ideal for quality of life...
January 9, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29315457/evaluation-of-sex-hormones-and-sperm-parameters-in-male-epileptic-patients
#12
L Ocek, H Tarhan, F I Uludağ, A Sarıteke, C Köse, A Colak, F Zorlu, Y Zorlu
OBJECTIVES: The aim of this study was to investigate the effect of carbamazepine (CBZ) and sodium valproate (VPA) monotherapy on sexual functions, sex hormones, and semen analysis and quality in male patients with epilepsy. METHODS: A total of 59 male patients with epilepsy, of which 30 were on VPA monotherapy and 29 were on CBZ monotherapy, were included in the study between January 2015 and March 2016. A control group was established with 30 healthy males. Luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), free testosterone (fT), estradiol (E2), sex hormone-binding globulin (SHBG) levels and bioactive testosterone (BAT)/bioactive estradiol (BAE), and BAT/LH ratio were studied in groups...
January 7, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29315236/understanding-the-role-of-intrinsic-disorder-of-viral-proteins-in-the-oncogenicity-of-different-types-of-hpv
#13
Elvira Regina Tamarozzi, Silvana Giuliatti
Intrinsic disorder is very important in the biological function of several proteins, and is directly linked to their foldability during interaction with their targets. There is a close relationship between the intrinsically disordered proteins and the process of carcinogenesis involving viral pathogens. Among these pathogens, we have highlighted the human papillomavirus (HPV) in this study. HPV is currently among the most common sexually transmitted infections, besides being the cause of several types of cancer...
January 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29312590/gnrh-agonist-treatment-for-idiopathic-central-precocious-puberty-can-improve-final-adult-height-in-chinese-girls
#14
Yanqin Ying, Jing Tang, Wei Chen, Zemin Cai, Wan Ting Niu
Object: To study the outcomes of GnRHa on final adult height in Chinese idiopathic central precocious puberty (ICPP) girls and the involved factor(s) that can predict height gain. Methods: We conducted a retrospective analysis on 10 years of data obtained from three clinical hospitals from January 2005 to March 2015, and 101 girls with ICPP, who received GnRHa therapy for more than six months and already reached their adult height were enrolled. Results: Height, bone age, midparent height, HtSDS, sexual development, therapy duration and predicted adult height(PAH)at start and end of GnRHa, and the final adult height(FAH) were recorded and calculated...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310655/methylene-blue-induced-morphological-deformations-in-plasmodium-falciparum-gametocytes-implications-for-transmission-blocking
#15
Ishan Wadi, C Radhakrishna Pillai, Anupkumar R Anvikar, Abhinav Sinha, Mahendra Nath, Neena Valecha
BACKGROUND: Malaria remains a global health problem despite availability of effective tools. For malaria elimination, drugs targeting sexual stages of Plasmodium falciparum need to be incorporated in treatment regimen along with schizonticidal drugs to interrupt transmission. Primaquine is recommended as a transmission blocking drug for its effect on mature gametocytes but is not extensively utilized because of associated safety concerns among glucose-6-phosphate dehydrogenase (G6PD) deficient patients...
January 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29309056/suppression-of-luteinizing-hormone-enhances-hsc-recovery-after-hematopoietic-injury
#16
Enrico Velardi, Jennifer J Tsai, Stefan Radtke, Kirsten Cooper, Kimon V Argyropoulos, Shieh Jae-Hung, Lauren F Young, Amina Lazrak, Odette M Smith, Sophie Lieberman, Fabiana Kreines, Yusuke Shono, Tobias Wertheimer, Robert R Jenq, Alan M Hanash, Prema Narayan, Zhenmin Lei, Malcolm A Moore, Hans-Peter Kiem, Marcel R M van den Brink, Jarrod A Dudakov
There is a substantial unmet clinical need for new strategies to protect the hematopoietic stem cell (HSC) pool and regenerate hematopoiesis after radiation injury from either cancer therapy or accidental exposure. Increasing evidence suggests that sex hormones, beyond their role in promoting sexual dimorphism, regulate HSC self-renewal, differentiation, and proliferation. We and others have previously reported that sex-steroid ablation promotes bone marrow (BM) lymphopoiesis and HSC recovery in aged and immunodepleted mice...
January 8, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29304991/a-multi-institutional-phase-2-trial-of-prostate-stereotactic-body-radiation-therapy-sbrt-using-continuous-real-time-evaluation-of-prostate-motion-with-patient-reported-quality-of-life
#17
William C Jackson, Robert T Dess, Dale W Litzenberg, Pin Li, Matthew Schipper, Seth A Rosenthal, Garrick C Chang, Eric M Horwitz, Robert A Price, Jeff M Michalski, Hiram A Gay, John T Wei, Mary Feng, Felix Y Feng, Howard M Sandler, Robert E Wallace, Daniel E Spratt, Daniel A Hamstra
PURPOSE: The use of stereotactic body radiation therapy (SBRT) for prostate cancer has been reported predominantly from single institutional studies, although concerns for broader adoption exist. METHODS AND MATERIALS: From 2011 through 2013, 66 men were accrued to a phase 2 trial at 5 centers. SBRT consisted of 5 fractions of 7.4 Gy to a total dose of 37 Gy using conventional linear accelerators. Electromagnetic transponders were used for motion management. Health-related quality of life (HRQOL) was evaluated via the Expanded Prostate Cancer Index Composite 26 questionnaire...
January 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29303101/-testosterone-therapy-indications-and-risks
#18
M G F Maatje, M Dinkelman-Smit, W P A Boellaard, G R Dohle
- Late onset hypogonadism (LOH) is a shortage of testosterone in adult men whose male development was normal. This form of hypogonadism results in decreased testosterone levels and variable gonadotrophin levels. - The symptoms of LOH are often aspecific and may be consistent with ageing in men: lowered libido, loss of strength, reduced cognitive functioning and disorders of sleeping and mood. - There is discussion about testosterone parameters, but if clinical symptoms are consistent with LOH and the testosterone level is < 8 nmol/l, hypogonadism is evidently indicated...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29303070/is-there-a-role-for-lifestyle-interventions-in-obsessive-compulsive-and-related-disorders
#19
Leonardo F Fontenelle, Julliana N Quintas, Murat Yücel
Many of the currently available treatments for obsessive-compulsive and related disorders (OCRDs) such as pharmacotherapy augmentation strategies, partial hospitalization programs, deep brain stimulation, and neurosurgery are efficacious for individuals suffering from more severe forms of these conditions. Unfortunately, the application of these treatments in milder forms of illness and subclinical samples, which affect a substantial portion of the population, is not justifiable by their costs (e.g. cognitive-behavioral therapy) and/or potential for side effects (serotonin-reuptake inhibitors associated sexual side effects)...
January 4, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29299903/delayed-ejaculation-pathophysiology-diagnosis-and-treatment
#20
REVIEW
Ibrahim A Abdel-Hamid, Omar I Ali
Delayed ejaculation (DE) is a poorly defined and uncommon form of male sexual dysfunction, characterized by a marked delay in ejaculation or an inability to achieve ejaculation. It is often quite concerning to patients and their partners, and sometimes frustrates couples' attempts to conceive. This article aims to review the pathophysiology of DE and anejaculation (AE), to explore our current understanding of the diagnosis, and to present the treatment options for this condition. Electronic databases were searched from 1966 to October 2017, including PubMed (MEDLINE) and Embase...
January 2018: World Journal of Men's Health
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