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https://www.readbyqxmd.com/read/28718527/evaluation-of-intralesional-injection-of-hyaluronic-acid-compared-with-verapamil-in-peyronie-s-disease-preliminary-results-from-a-prospective-double-blinded-randomized-study
#1
V Favilla, G I Russo, A Zucchi, G Siracusa, S Privitera, S Cimino, M Madonia, T Cai, G Cavallini, G Liguori, G D'Achille, M Silvani, G Franco, P Verze, A Palmieri, B Torrisi, V Mirone, G Morgia
Several intralesional therapeutic protocols have been proposed for the treatment of Peyronie's disease. Among all, hyaluronic acid (HA) and verapamil have been differently tested. We aimed to evaluate the efficacy of intralesional verapamil (ILVI) compared with intralesional HA in patients with early onset of Peyronie's disease (PD). This is a multi-centre prospective double-arm, randomized, double-blinded study comparing ILVI vs. intralesional HA after 12-weeks. Sexually active men, older than 18 years and affected by the acute phase of PD were eligible for this study...
July 2017: Andrology
https://www.readbyqxmd.com/read/28718489/-profile-of-transvestites-and-transgender-women-tuberculosis-and-hiv-aids-in-the-city-of-s%C3%A3-o-paulo
#2
Sérgio Ferreira, Priscila Maria Stolses Bergamo Francisco, Péricles Alves Nogueira
Objective: To characterize the profile of transvestites and transgender women participating in a survey regarding tuberculosis and HIV/Aids in the city of São Paulo. Method: This cross-sectional study employed the Knowledge, Attitudes and Practices (KAP) questionnaire adapted for data collection. Sociodemographic aspects as well as aspects related to history of imprisonment, process of gender transition, use of condoms, previous treatment of sexually transmitted diseases and tuberculosis and knowledge regarding HIV/Aids were addressed...
December 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28717512/trauma-related-emotions-and-radical-acceptance-in-dialectical-behavior-therapy-for-posttraumatic-stress-disorder-after-childhood-sexual-abuse
#3
Nora Görg, Kathlen Priebe, Jan R Böhnke, Regina Steil, Anne S Dyer, Nikolaus Kleindienst
BACKGROUND: Posttraumatic Stress Disorder (PTSD) related to childhood sexual abuse (CSA) is often associated with a wide range of trauma-related aversive emotions such as fear, disgust, sadness, shame, guilt, and anger. Intense experience of aversive emotions in particular has been linked to higher psychopathology in trauma survivors. Most established psychosocial treatments aim to reduce avoidance of trauma-related memories and associated emotions. Interventions based on Dialectical Behavior Therapy (DBT) also foster radical acceptance of the traumatic event...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28717267/semen-culture-and-the-assessment-of-genitourinary-tract-infections
#4
REVIEW
Michael Solomon, Ralf Henkel
The male factor contributes approximately 50% to infertility-related cases in couples with an estimated 12%-35% of these cases attributable to male genital tract infections. Depending on the nature of the infection, testicular sperm production, sperm transport, and sperm function can be compromised. Yet, infections are potentially treatable causes of infertility. Male genital tract infections are increasingly difficult to detect. Moreover, they often remain asymptomatic ("silent") with the result that they are then passed on to the relevant sexual partner leading to fertilization and pregnancy failure as well as illness of the offspring...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28717051/detection-of-markers-predictive-of-macrolide-and-fluoroquinolone-resistance-in-mycoplasma-genitalium-from-patients-attending-sexual-health-services-in-england
#5
Rachel Pitt, Helen Fifer, Neil Woodford, Sarah Alexander
OBJECTIVES: Resistance to both macrolides and fluoroquinolones has been reported in Mycoplasma genitalium; however, due to limited diagnostics, studies are often small and confined to specific geographical areas. This study sought to determine the rate of predicted resistance in M. genitalium-positive specimens referred for diagnostic testing. METHODS: Seventy-four M. genitalium-positive specimens, referred to the national reference laboratory (2010-2013) from 19 centres across England, were blinded and anonymised...
July 17, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28714321/zoophilia-in-an-adolescent-with-high-functioning-autism-from-sri-lanka
#6
Miyuru Chandradasa, Layani Champika
OBJECTIVE: Zoophilia is a rare paraphilic disorder with intense sexual urges involving animals. Autism is characterised by impairments in social communication and repetitive, restricted behaviours (RRB). Reported cases of zoophilia are limited worldwide, and zoophilia in autism is rarer. METHOD: This is a case report describing this unique and relatively unrecognised association in a male adolescent from Sri Lanka. RESULTS: A 17-year-old boy diagnosed with autism has average intelligence and academic capabilities...
July 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28712040/the-effect-of-targeted-therapy-for-genitourinary-malignancies-on-sexual-function-and-fertility
#7
REVIEW
Bradley C Holland, Zubin Shetty, Shaheen Alanee
PURPOSE OF REVIEW: Targeted therapy for genitourinary cancer is being used at an increasing rate. These medications show great survival benefit but are relatively lacking in long-term adverse effect data. With increasing survivability, measures to improve quality of life must be considered for GU cancer and a large proponent of this is sexual function. RECENT FINDINGS: mTOR inhibitors have shown an effect on testosterone levels and may have a link to abnormal semen parameters...
August 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28704329/long-term-oncological-outcome-after-conventional-radical-hysterectomy-versus-2-nerve-sparing-modalities-for-early-stage-cervical-cancer
#8
Mignon Dingena Johanna Maria van Gent, Mandy Rademaker, Johanna Cornelia Bernadette van der Veer, Mariëtte Inie Elizabeth van Poelgeest, Katja Nicoline Gaarenstroom, Hein Putter, Johannes Baptist Maria Zacharias Trimbos, Cor Doede de Kroon
OBJECTIVES: Nerve-sparing radical hysterectomy for early stage cervical cancer was introduced to improve quality of life after treatment. Sparing the pelvic autonomic nerves reduces bladder, bowel, and sexual dysfunction. The Leiden nerve-sparing radical hysterectomy (LNSRH) was modified to the Swift procedure, the latter being more radical regarding the sacrouterine and parametrial resection. We investigate whether nerve-sparing surgery has comparable oncological outcomes as the conventional radical hysterectomy (CRH)...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28702986/electromagnetic-field-in-control-tissue-regeneration-pelvic-pain-neuro-inflammation-and-modulation-of-non-neuronal-cells
#9
S E Aragona, G Mereghetti, G Gianazza, A Salsa, G Gianazza, J Lotti, A Vosa, T Lotti, E Canavesi
In scientific literature, magnetic fields are used both in basic science and clinical research. They are often used to treat pain and neuro-inflammation disorders thanks to their influence on cellular responses. Our project was born from the regenerative support that we wanted to give to those diseases characterized by neuro-inflammation, nerve lesion, muscles and tissues disorders that can transform the symptom (e.g. neuropathic pelvic pain) in disease. In this study, we examined the action of pulsed electromagnetic fields (PEMFs) on skin lesion regeneration and the repetitive trans-pelvic magnetic stimulation (rTPMS) on patients affected by incontinence and post-surgical problems, sexual dysfunction, and pelvic pain...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702510/phosphodiesterase-5-inhibitors-for-premature-ejaculation-a-systematic-review-and-meta-analysis
#10
Marrissa Martyn-St James, Katy Cooper, Shijie Ren, Eva Kaltenthaler, K Dickinson, A Cantrell, Kevan Wylie, Leila Frodsham, Catherine Hood
CONTEXT: Phosphodiesterase-5 inhibitors (PDE5is) are prescribed off-label for the treatment of premature ejaculation (PE). OBJECTIVE: To systematically review the evidence from randomised controlled trials (RCTs) for PDE5is in the management of PE. EVIDENCE ACQUISITION: MEDLINE and other databases were searched to September 2015. Quality of RCTs was assessed. Intra-vaginal ejaculatory latency time (IELT) data were pooled in a meta-analysis...
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28701798/cognitive-behavioral-therapy-as-an-adjunct-treatment-for-pakistani-men-with-ed
#11
S Khan, A Amjad, D Rowland
The goal of this study was to determine potential positive effects of cognitive behavioral therapy (CBT) on Pakistani men with ED who were undergoing treatment with a PDE-5 inhibitor. We used a pre-post research design comparing men with and without adjunctive CBT. Men in the two groups were compared to determine whether CBT improved sexual function, as measured by the International Index of Erectile Function (IIEF). A total of 60 individuals diagnosed with ED completed the study. Participants were systematically assigned to one of two groups, the CBT group or the control group...
July 13, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28701725/prospective-study-on-association-of-prostatic-calcifications-with-clinical-symptoms-and-results-of-treatment-in-men-with-type-iii-prostatitis
#12
Xiang Fei, Wei Jin, Shengyu Hua, Yan Song
The purpose is to investigate the clinical significance of prostatic calculi in patients with chronic prostatitis and to discuss the possible treatment.The data from 277 young males with CP/CPPS were analyzed prospectively. Symptom severity was measured using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and the International Prostatic Symptoms Score (IPSS). Sexual function was assessed by the International Index of Erectile Function (IIEF-5) questionnaire. After four weeks of therapy, the NIH-CPSI, IPSS, and IIEF-5 tests were repeated...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28701272/sexually-transmitted-infections-challenges-ahead
#13
REVIEW
Magnus Unemo, Catriona S Bradshaw, Jane S Hocking, Henry J C de Vries, Suzanna C Francis, David Mabey, Jeanne M Marrazzo, Gerard J B Sonder, Jane R Schwebke, Elske Hoornenborg, Rosanna W Peeling, Susan S Philip, Nicola Low, Christopher K Fairley
WHO estimated that nearly 1 million people become infected every day with any of four curable sexually transmitted infections (STIs): chlamydia, gonorrhoea, syphilis, and trichomoniasis. Despite their high global incidence, STIs remain a neglected area of research. In this Commission, we have prioritised five areas that represent particular challenges in STI treatment and control. Chlamydia remains the most commonly diagnosed bacterial STI in high-income countries despite widespread testing recommendations, sensitive and specific non-invasive testing techniques, and cheap effective therapy...
July 7, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28700693/risk-factors-for-delayed-antiretroviral-therapy-initiation-among-hiv-seropositive-patients
#14
Terra V Fatukasi, Stephen R Cole, Richard D Moore, William C Mathews, Jessie K Edwards, Joseph J Eron
Prompt initiation of combination antiretroviral therapy (ART) is important to reduce comorbidity and mortality among people living with HIV, especially for those with a low CD4 cell count. However there is evidence that not everyone receives prompt initiation of ART after enrolling into HIV care. The current study investigated factors associated with failure to initiate ART within two years of entering into care among those with a CD4 count at or below 350 cells/mm3. The sample included 4,907 ART-naive patients with a CD4 count at or below 350 cells/mm3 enrolled between January 1, 2003 and December 31, 2012 at any of eight clinical sites in the Center for AIDS Research Network of Integrated Clinical Systems (CNICS)...
2017: PloS One
https://www.readbyqxmd.com/read/28700391/human-t-lymphotropic-virus-type-1-infection-and-disease-in-spain
#15
Carmen de Mendoza, Estrella Caballero, Antonio Aguilera, Silvia Requena, Raúl Ortiz de Lejarazu, María Pirón, Rocío González, Ana Jiménez, Lourdes Roc, Ana Treviño, Rafael Benito, Miriam Fernández-Alonso, Aitziber Aguinaga, Carmen Rodríguez, Juan García-Costa, Lidia Blanco, José M Ramos, Enrique Calderón, José M Eirós, Silvia Sauleda, Pablo Barreiro, Vicente Soriano
: Human T-lymphotropic virus type 1 (HTLV-1) infection is a neglected disease despite roughly 15 million people are chronically infected worldwide. Lifelong less than 10% of carriers develop life-threatening diseases, mostly a subacute myelopathy known as tropical spastic paraparesis (TSP) and a lymphoproliferative disorder named adult T-cell leukemia (ATL). HTLV-1 is efficiently transmitted perinatally (breastfeeding), sexually (more from men to women) and parenterally (transfusions, injection drug user (IDU), and transplants)...
July 31, 2017: AIDS
https://www.readbyqxmd.com/read/28698869/effects-of-poly-adp-ribose-polymerase-1-inhibition-in-a-neonatal-rodent-model-of-hypoxic-ischemic-injury
#16
Melanie Klöfers, Jules Kohaut, Ivo Bendix, Josephine Herz, Vinzenz Boos, Ursula Felderhoff-Müser, Mark Dzietko
BACKGROUND: Hypoxia ischemia (HI) to the developing brain occurs in 1-6 in 1000 live births. Large numbers of survivors have neurological long-term sequelae. However, mechanisms of recovery after HI are not understood and preventive measures or clinical treatments are not effective. Poly(ADP-ribose) polymerase-1 is overactivated in response to ischemia. In neonatal mice HI activates PARP-1 but its role in perinatal brain injury remains uncertain. OBJECTIVE: Aim of this study was to explore the effect of TES448 (PARP-1-inhibitor) and hypothermia after an ischemic insult...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28698211/extra-rectal-lymphogranuloma-venereum-in-france-a-clinical-and-molecular-study
#17
Arnaud Desclaux, Arabella Touati, Didier Neau, Cécile Laurier-Nadalié, Cécile Bébéar, Bertille de Barbeyrac, Charles Cazanave
OBJECTIVES: To describe a series of extrarectal lymphogranuloma venereum (LGV) cases diagnosed in France. METHODS: Consecutive LGV cases confirmed at the French Reference Centre for chlamydiae with an extrarectal sample from January 2010 to December 2015 were included. The first part of the study consisted of a retrospective case note review and analysis. In a second part, the complete ompA gene sequence of our samples was determined. RESULTS: There were 56 cases overall: 50 cases of genital LGV and six cases of pharyngeal LGV...
July 11, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28697624/evaluating-a-novel-intervention-to-reduce-trauma-symptoms-and-sexual-risk-taking-qualitative-exit-interviews-with-sexual-minority-men-with-childhood-sexual-abuse
#18
S Wade Taylor, Brett M Goshe, Samantha M Marquez, Steven A Safren, Conall O'Cleirigh
Childhood sexual abuse (CSA) continues to affect sexual minority men (SMM) at disproportionate levels and contributes to multiple negative health outcomes, including sexual-risk taking and HIV acquisition. This paper presents qualitative evaluative feedback from SMM (N = 9) who participated in a 10-session Cognitive Behavioral Therapy-Trauma and Sexual Health (CBT-TSH) intervention to reduce CSA-related posttraumatic stress reaction and distress. The treatment was designed to increase accurate sexual risk appraisals and to improve self-care health behaviors related to HIV/STI acquisition...
July 12, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28697104/lipsch%C3%A3-tz-ulcers-a-rare-diagnosis-in-women-with-vulvar-ulceration
#19
Vera Wolters, Isabella Hoogslag, Jan Vanʼ T Wout, Kim Boers
BACKGROUND: Lipschütz ulcers are characterized by painful vulvar ulceration, most commonly in young women. Because these lesions are so rarely seen, the diagnosis can be challenging. CASE: An 18-year-old woman, without any prior sexual activity, developed painful blue vulval lesions. These became necrotizing ulcers, and she began antiviral therapy for presumptive herpes infection. Herpes cultures, however, were negative. Serology consistent with a recent Epstein-Barr virus infection resulted in a diagnosis of Lipschütz ulcers...
July 7, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28692231/-the-menopausal-hormone-therapy-in-2016
#20
Evangelia Pavlidou, Paul Pirtea, Isabelle Streuli
The menopausal hormone therapy (MHT) is the first line treatment for climacteric symptoms related to estrogen deficiency. A personalized evaluation of the benefit-risk ratio should precede a MHT prescription, and take into consideration cardiovascular, thromboembolic, oncological and osteoporosis risks. MHT should be prescribed at the lowest effective dose and for the shortest duration, respecting the window of opportunity in the 10 years following menopause or before the age of 60 years. The choice of the MHT type depends on the patient's profile, her medical history and personal preferences, with the aim of improving quality of life from a physical, psychological and sexual point of view...
October 26, 2016: Revue Médicale Suisse
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