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https://www.readbyqxmd.com/read/29161350/embedded-performance-validity-tests-in-the-hopkins-verbal-learning-test-revised-and-the-brief-visuospatial-memory-test-revised-a-replication-study
#1
K Chase Bailey, Jason R Soble, Kathleen M Bain, Chrystal Fullen
Objective: Embedded performance validity tests (PVTs) within the Hopkins Verbal Learning Test-Revised (HVLT-R) and Brief Visuospatial Memory Test-Revised (BVMT-R) were recently identified. This study aimed to further validate/replicate these embedded PVTs. Method: Eighty clinically referred veterans who underwent neuropsychological evaluation were included. Validity groups were established by passing/failing 2-3 well-validated PVTs, with 75% (n = 60) classified as valid and 25% (n = 20) noncredible...
November 17, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29154123/3d-skeletonization-feature-based-computer-aided-detection-system-for-pulmonary-nodules-in-ct-datasets
#2
Weihang Zhang, Xue Wang, Xuanping Li, Junfeng Chen
Pulmonary nodule detection has a significant impact on early diagnosis of lung cancer. To effectively detect pulmonary nodules from interferential vessels in chest CT datasets, this paper proposes a novel 3D skeletonization feature, named as voxels remove rate. Based on this feature, a computer-aided detection system is constructed to validate its performance. The system mainly consists of five stages. Firstly, the lung tissues are segmented by a global optimal active contour model, which can extract all structures (including juxta-pleural nodules) in the lung region...
November 11, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29145307/computed-tomography-guided-percutaneous-cutting-needle-biopsy-for-small-%C3%A2-20%C3%A2-mm-lung-nodules
#3
Guang-Chao Li, Yu-Fei Fu, Wei Cao, Yi-Bing Shi, Tao Wang
The goal of this study is to determine the feasibility, diagnostic accuracy, and risk factor of complications of computed tomography (CT)-guided percutaneous cutting needle biopsy (PCNB) for small lung nodules.From January 2014 to May 2015, 141 patients with small lung nodule were performed with CT-guided PCNB procedure. Data on technical success, diagnostic accuracy, and complication were collected and analyzed.Technical success of CT-guided PCNB for small lung nodules was 100%. A total of 141 nodules were punctured...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29140933/t-spot-tb%C3%A2-performance-in-routine-pediatric-practice-in-a-low-tb-burden-setting
#4
Anna M Mandalakas, Heather Y Highsmith, Nadine M Harris, Anna Pawlicka, H Lester Kirchner
BACKGROUND: The T-SPOT.TB, an interferon-γ release assay (IGRA), is an indirect test of Mycobacterium tuberculosis infection. Due to sparse and conflicting evidence, IGRA use is limited in young and HIV-infected children. We determined the prevalence of invalid, borderline, positive, and negative results and associations with key demographic variables during routine pediatric use in a TB low-burden setting. METHODS: For pediatric samples received at Oxford Diagnostic Laboratories from 2010-2015, the associations between initial test outcome and demographics were estimated by bivariate analysis and logistic regression...
November 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29138658/-femoral-varising-osteotomy-by-external-opening-for-the-treatment-of-lateral-femorotibial-gonarthroses-associated-with-idiopathic-genu-valgum-a-retrospective-a-study-of-10-cases
#5
Asma Ben Cheikh, Mahmoud Ben Maitigue, Karim Masmoudi, Thabet Mouelhi, Nader Naouar, Yamen Grissa, Karim Bouattour, Walid Osman, Mohamed Laziz Ben Ayeche
Femoral varus osteotomy is a conservative treatment for external single-compartment gonarthrosis. This surgical procedure is little used and outcomes are little studied.This study aimed to assess the clinical and radiological results of femoral varising osteotomy in subjects with external femorotibial gonarthrosis associated with idiopathic genu valgum whose data were recorded over a period of 21 years (1992- 2013) in the Department of Orthopedics at Sahloul University Hospital, Sousse. The clinical evaluation of patients was performed using the IKS score (International Knee Society)...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29114564/the-effect-of-pretest-exercise-on-baseline-computerized-neurocognitive-test-scores
#6
Alec Pawlukiewicz, Aaron M Yengo-Kahn, Gary Solomon
Background: Baseline neurocognitive assessment plays a critical role in return-to-play decision making following sport-related concussions. Prior studies have assessed the effect of a variety of modifying factors on neurocognitive baseline test scores. However, relatively little investigation has been conducted regarding the effect of pretest exercise on baseline testing. Purpose/Hypothesis: The aim of our investigation was to determine the effect of pretest exercise on baseline Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) scores in adolescent and young adult athletes...
October 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29104875/a-novel-system-for-the-quantification-of-the-adcc-activity-of-therapeutic-antibodies
#7
Christophe Lallemand, Feifei Liang, Flore Staub, Maud Simansour, Benoit Vallette, Lue Huang, Rosa Ferrando-Miguel, Michael G Tovey
Novel ADCC effector cells expressing the V-variant or F-variant of FcγRIIIa (CD16a) and firefly luciferase under the control of a chimeric promoter incorporating recognition sequences for the principal transcription factors involved in FcγRIIIa signal transduction, together with novel target cells overexpressing a constant high level of the specific antigen recognized by rituximab, trastuzumab, cetuximab, infliximab, adalimumab, or etanercept, confer improved sensitivity, specificity, and dynamic range in an ADCC assay relative to effector cells expressing a NFAT-regulated reporter gene and wild-type target cells...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29069278/performance-validity-neurocognitive-disorder-and-post-concussion-symptom-reporting-in-service-members-with-a-history-of-mild-traumatic-brain-injury
#8
Sara M Lippa, Rael T Lange, Louis M French, Grant L Iverson
Objective: To examine the influence of different performance validity test (PVT) cutoffs on neuropsychological performance, post-concussion symptoms, and rates of neurocognitive disorder and postconcussional syndrome following mild traumatic brain injury (MTBI) in active duty service members. Method: Participants were 164 service members (Age: M = 28.1 years [SD = 7.3]) evaluated on average 4.1 months (SD = 5.0) following injury. Participants were divided into three mutually exclusive groups using original and alternative cutoff scores on the Test of Memory Malingering (TOMM) and the Effort Index (EI) from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): (a) PVT-Pass, n = 85; (b) Alternative PVT-Fail, n = 53; and (c) Original PVT-Fail, n = 26...
October 21, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29060845/smartphone-based-automatic-organ-validation-in-ultrasound-video
#9
Pallavi Vaish, R Bharath, P Rajalakshmi
Telesonography involves transmission of ultrasound video from remote areas to the doctors for getting diagnosis. Due to the lack of trained sonographers in remote areas, the ultrasound videos scanned by these untrained persons do not contain the proper information that is required by a physician. As compared to standard methods for video transmission, mHealth driven systems need to be developed for transmitting valid medical videos. To overcome this problem, we are proposing an organ validation algorithm to evaluate the ultrasound video based on the content present...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29040600/robust-inference-in-summary-data-mendelian-randomization-via-the-zero-modal-pleiotropy-assumption
#10
Fernando Pires Hartwig, George Davey Smith, Jack Bowden
Background: Mendelian randomization (MR) is being increasingly used to strengthen causal inference in observational studies. Availability of summary data of genetic associations for a variety of phenotypes from large genome-wide association studies (GWAS) allows straightforward application of MR using summary data methods, typically in a two-sample design. In addition to the conventional inverse variance weighting (IVW) method, recently developed summary data MR methods, such as the MR-Egger and weighted median approaches, allow a relaxation of the instrumental variable assumptions...
July 12, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29035455/evaluation-of-a-magnetic-cellulose-based-dna-extraction-system-to-improve-the-performance-of-hybribio-human-papillomavirus-genotyping-and-screening-tests-for-cervical-swab-samples
#11
Zengge Wang, Yulin Zhou, Jun Ren, Zhongmin Xia, Qiwei Guo
BACKGROUND: To ensure the accuracy of clinical human papillomavirus (HPV) testing, the nucleic acid extraction procedure should be thoroughly evaluated for each clinical sample type. Therefore, we evaluated whether the MagCore® Automated Nucleic Acid Extraction system (MagCore system) could improve HybriBio HPV test performance for cervical swab samples. METHODS: We compared the performance of HybriBio HPV genotyping and screening tests using samples prepared with the MagCore system and Cell Lysis Kit, which was provided by the HPV test manufacturer...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29031761/reduced-p300-amplitude-during-a-visuospatial-attention-task-in-idiopathic-rapid-eye-movement-sleep-behavior-disorder
#12
Jung-Ick Byun, Byeong Uk Lee, Minah Kim, Jun-Sang Sunwoo, Jung-Ah Lim, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Man-Ho Kim, Min Hee Jeong, Kwang Su Cha, Jeong Woo Choi, Kyung Hwan Kim, Sang Kun Lee, Ki-Young Jung
OBJECTIVES: Idiopathic rapid eye movement sleep behavior disorder (IRBD) patients are prone to cognitive deficits, which include attention, executive, and visuospatial dysfunctions. Even patients with normal cognition may exhibit subclinical electrophysiological dysfunction. This study aimed to evaluate visuospatial attention processing in IRBD patients with normal cognition and to compare their findings with those of age- and sex-matched healthy controls. METHODS: We recorded event-related potentials (ERPs) and performance measures during a variant of the Posner task in 14 IRBD patients and 14 control subjects...
October 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29028924/survivor-bias-in-mendelian-randomization-analysis
#13
Stijn Vansteelandt, Oliver Dukes, Torben Martinussen
Mendelian randomization studies employ genotypes as experimental handles to infer the effect of genetically modified exposures (e.g. vitamin D exposure) on disease outcomes (e.g. mortality). The statistical analysis of these studies makes use of the standard instrumental variables framework. Many of these studies focus on elderly populations, thereby ignoring the problem of left truncation, which arises due to the selection of study participants being conditional upon surviving up to the time of study onset...
September 27, 2017: Biostatistics
https://www.readbyqxmd.com/read/28981585/specific-visual-subregions-of-tpj-mediate-reorienting-of-spatial-attention
#14
Laura Dugué, Elisha P Merriam, David J Heeger, Marisa Carrasco
The temporo-parietal junction (TPJ) has been associated with various cognitive and social functions, and is critical for attentional reorienting. Attention affects early visual processing. Neuroimaging studies dealing with such processes have thus far concentrated on striate and extrastriate areas. Here, we investigated whether attention orienting or reorienting modulate activity in visually driven TPJ subregions. For each observer we identified 3 visually responsive subregions within TPJ: 2 bilateral (vTPJant and vTPJpost) and 1 right lateralized (vTPJcent)...
June 13, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28981430/detection-of-sources-in-non-negative-blind-source-separation-by-minimum-description-length-criterion
#15
Chia-Hsiang Lin, Chong-Yung Chi, Lulu Chen, David J Miller, Yue Wang
While non-negative blind source separation (nBSS) has found many successful applications in science and engineering, model order selection, determining the number of sources, remains a critical yet unresolved problem. Various model order selection methods have been proposed and applied to real-world data sets but with limited success, with both order over- and under-estimation reported. By studying existing schemes, we have found that the unsatisfactory results are mainly due to invalid assumptions, model oversimplification, subjective thresholding, and/or to assumptions made solely for mathematical convenience...
October 3, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28968752/non-regular-inference-for-dynamic-weighted-ordinary-least-squares-understanding-the-impact-of-solid-food-intake-in-infancy-on-childhood-weight
#16
Gabrielle Simoneau, Erica E M Moodie, Robert W Platt, Bibhas Chakraborty
A dynamic treatment regime (DTR) is a set of decision rules to be applied across multiple stages of treatments. The decisions are tailored to individuals, by inputting an individual's observed characteristics and outputting a treatment decision at each stage for that individual. Dynamic weighted ordinary least squares (dWOLS) is a theoretically robust and easily implementable method for estimating an optimal DTR. As many related DTR methods, the dWOLS treatment effects estimators can be non-regular when true treatment effects are zero or very small, which results in invalid Wald-type or standard bootstrap confidence intervals...
August 21, 2017: Biostatistics
https://www.readbyqxmd.com/read/28967952/real-time-methylation-specific-polymerase-chain-reaction-for-mgmt-promoter-methylation-clinical-testing-in-glioblastoma-an-alternative-detection-method-for-a-heterogeneous-process
#17
Cristiane M Ida, Malinda L Butz, Robert B Jenkins, Jann N Sarkaria, Gaspar J Kitange, Caterina Giannini, Benjamin R Kipp
Objectives: To develop and evaluate a real-time methylation-specific polymerase chain reaction (RT-MSP) MGMT assay, with a particular focus on small biopsies and indeterminate testing results. Methods: We assessed formalin-fixed paraffin-embedded glioblastoma or gliosarcoma specimens (n = 641). A test-validation group (n = 51) with previously obtained reference laboratory (RL) results was used to determine performance characteristics of the RT-MSP assay. An indeterminate (equivocal) category was established for cases that could not be clearly classified as positive or negative...
October 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28961684/validity-and-reliability-of-baseline-testing-in-a-standardized-environment
#18
Kathryn L Higgins, Todd Caze, Arthur Maerlender
Objective: The Immediate Postconcussion Assessment and Cognitive Testing (ImPACT) is a computerized neuropsychological test battery commonly used to determine cognitive recovery from concussion based on comparing post-injury scores to baseline scores. This model is based on the premise that ImPACT baseline test scores are a valid and reliable measure of optimal cognitive function at baseline. Growing evidence suggests that this premise may not be accurate and a large contributor to invalid and unreliable baseline test scores may be the protocol and environment in which baseline tests are administered...
August 11, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28956113/implementing-diffusion-weighted-mri-for-body-imaging-in-prospective-multicentre-trials-current-considerations-and-future-perspectives
#19
N M deSouza, J M Winfield, J C Waterton, A Weller, M-V Papoutsaki, S J Doran, D J Collins, L Fournier, D Sullivan, T Chenevert, A Jackson, M Boss, S Trattnig, Y Liu
For body imaging, diffusion-weighted MRI may be used for tumour detection, staging, prognostic information, assessing response and follow-up. Disease detection and staging involve qualitative, subjective assessment of images, whereas for prognosis, progression or response, quantitative evaluation of the apparent diffusion coefficient (ADC) is required. Validation and qualification of ADC in multicentre trials involves examination of i) technical performance to determine biomarker bias and reproducibility and ii) biological performance to interrogate a specific aspect of biology or to forecast outcome...
September 27, 2017: European Radiology
https://www.readbyqxmd.com/read/28937464/comparison-of-clinical-outcomes-after-anterior-cervical-discectomy-and-fusion-versus-cervical-total-disk-replacement-in-patients-with-modic-2-changes-on-mri
#20
Jia Li, Di Zhang, Wenyuan Ding, Yingze Zhang, Yong Shen
STUDY DESIGN: A retrospective investigation. OBJECTIVE: The aim of this research is to compare the clinical and radiologic outcomes of patients with Modic-2 changes who underwent anterior cervical discectomy and fusion (ACDF) or cervical total disk replacement (TDR) in single level. SUMMARY OF BACKGROUND DATA: There were few studies focused on the clinical and radiologic outcomes of patients with Modic-2 changes who underwent ACDF or cervical TDR in single level...
October 2017: Clinical Spine Surgery
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