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https://www.readbyqxmd.com/read/29777117/a-logic-based-method-to-build-signaling-networks-and-propose-experimental-plans
#1
Adrien Rougny, Pauline Gloaguen, Nathalie Langonné, Eric Reiter, Pascale Crépieux, Anne Poupon, Christine Froidevaux
With the dramatic increase of the diversity and the sheer quantity of biological data generated, the construction of comprehensive signaling networks that include precise mechanisms cannot be carried out manually anymore. In this context, we propose a logic-based method that allows building large signaling networks automatically. Our method is based on a set of expert rules that make explicit the reasoning made by biologists when interpreting experimental results coming from a wide variety of experiment types...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772219/differential-roles-of-polar-orbital-prefrontal-cortex-and-parietal-lobes-in-logical-reasoning-with-neutral-and-negative-emotional-content
#2
Iveta Eimontaite, Vinod Goel, Vanessa Raymont, Frank Krueger, Igor Schindler, Jordan Grafman
To answer the question of how brain pathology affects reasoning about negative emotional content, we administered a disjunctive logical reasoning task involving arguments with neutral content (e.g. Either there are tigers or women in NYC, but not both; There are no tigers in NYC; There are women in NYC) and emotionally laden content (e.g. Either there are pedophiles or politicians in Texas, but not both; There are politicians in Texas; There are no pedophiles in Texas) to 92 neurological patients with focal lesions to various parts of the brain...
May 14, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29754393/predicting-stress-urinary-incontinence-during-pregnancy-combination-of-pelvic-floor-ultrasound-parameters-and-clinical-factors
#3
Ling Chen, Dan Luo, Xiajuan Yu, Mei Jin, Wenzhi Cai
INTRODUCTION: The aim of this study was to develop and validate a predictive tool that combining pelvic floor ultrasound parameters and clinical factors for stress urinary incontinence during pregnancy. MATERIAL AND METHODS: A total of 535 women in first or second trimester were included for an interview and transperineal ultrasound assessment from two hospitals. Imaging data sets were analyzed offline to assess for bladder neck vertical position, urethra angles (α, β, and γ angles), hiatal area and bladder neck funneling...
May 12, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29731731/the-ir-responsibility-of-under-estimating-missing-data
#4
María P Fernández-García, Guillermo Vallejo-Seco, Pablo Livácic-Rojas, Ellian Tuero-Herrero
It is practically impossible to avoid losing data in the course of an investigation, and it has been proven that the consequences can reach such magnitude that they could even invalidate the results of the study. This paper describes some of the most likely causes of missing data in research in the field of clinical psychology and the consequences they may have on statistical and substantive inferences. When it is necessary to recover the missing information, analyzing the data can become extremely complex...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29729836/prognostic-value-of-egfr-family-expression-in-lymph-node-negative-esophageal-squamous-cell-carcinoma-patients
#5
Weiwei Yu, Xi Yang, Li Chu, Kuaile Zhao, Haiquan Chen, Jiaqing Xiang, Yawei Zhang, Hecheng Li, Weixin Zhao, Menghong Sun, Qiao Wei, Xiaolong Fu, Congying Xie, Zhengfei Zhu
The human epidermal growth factor receptor (EGFR) family has been widely studied in cancer, however, the prognostic role of EGFR family expression in lymph node-negative esophageal squamous cell carcinoma (ESCC) patients have not been invalidated. This study was designed to determine the prognostic value of EGFR family expression in a population of lymph node-negative ESCC patients treated with curative resection. EGFR family protein expression was examined by immunohistochemical analysis of tissue microarrays of 94 patients with lymph node-negative ESCC after radical esophagectomy with three-field lymphadenectomy...
April 30, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29682704/-anastomotic-leakage-after-rectal-cancer-surgery-classification-and-management
#6
Pan Chi, Shenghui Huang
Many studies have focused on the identification of risk factors and prevention of anastomotic leakage following rectal cancer surgery. However, there is little knowledge regarding classification and management of anastomotic leakage in clinic. Herein, we reviewed and summarized the classification and management of anastomotic leakage after rectal cancer surgery. The relevant treatments of anastomotic leakage should be chosen based on patient's manifestation, including general and local reactions, anatomical location, and nature of the leakage (contained or free, controlled or uncontrolled leakage)...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29660903/complex-cystic-and-solid-breast-lesions-diagnostic-performance-of-conventional-ultrasound-strain-imaging-and-point-shear-wave-speed-measurement
#7
Ying Zhang, Hui-Xiong Xu, Chong-Ke Zhao, Xiao-Long Li, Xiao-Wan Bo, Ya-Ping He, Bo-Ji Liu, Dan Wang, Wei-Wei Ren
OBJECTIVE: To assess the performance of conventional high frequency ultrasound (US) and US elastography in diagnosis of complex cystic and solid breast lesions. METHODS: Ninety three lesions in 93 patients underwent conventional US and US elastography, including strain elastography, acoustic radiation force impulse (ARFI) imaging, and point shear wave speed (SWS) measurement. RESULTS: Pathological examination revealed 31 (33.3%) of the 93 lesions were malignant and the remaining 62 (66...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29656969/the-leukocyte-esterase-test-strip-is-a-poor-rule-out-test-for-periprosthetic-joint-infection
#8
Carl A Deirmengian, Lihua Liang, John P Rosenberger, Tony R Joaquim, Martin R Gould, Patrick A Citrano, Keith W Kardos
BACKGROUND: The urinary leukocyte esterase (LE) test strip has been suggested as a good screening test for periprosthetic joint infection (PJI). The purpose of this study is to compare the diagnostic profile of LE assays from different manufacturers and determine whether the LE test strip is a good rule-out test. METHODS: Synovial fluid samples (N = 344), sent to 1 laboratory for PJI testing, were used in this prospective study. Four different tests for synovial fluid LE were simultaneously evaluated for their performance in detecting white blood cell (WBC) positive samples (>3000 cells/µL)...
March 13, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29649084/vertebral-augmentation-can-induce-early-signs-of-degeneration-in-the-adjacent-intervertebral-disc-evidence-from-a-rabbit-model
#9
Zhiyun Feng, Lunhao Chen, Xiaojian Hu, Ge Yang, Yue Wang, Zhong Chen
STUDY DESIGN: An experimental study. OBJECTIVE: The aim of this study was to determine the effect of polymethylmethacrylate (PMMA) augmentation on the adjacent disc. SUMMARY OF BACKGROUND DATA: Vertebral augmentation with PMMA reportedly may predispose the adjacent vertebra to fracture. The influence of PMMA augmentation on the adjacent disc, however, remains unclear. METHODS: Using a retroperitoneal approach, PMMA augmentation was performed for 23 rabbits...
April 11, 2018: Spine
https://www.readbyqxmd.com/read/29627895/toosendanin-mediates-cisplatin-sensitization-through-targeting-annexin-a4-atp7a-in-non-small-cell-lung-cancer-cells
#10
Mao Dong Zheng, Nai Dong Wang, Xiao Liang Li, Juan Yan, Jian Hua Tang, Xiu Hua Zhao, Zhihua Zhang
Cisplatin (CDDP) is used in the treatment of non-small cell lung cancer (NSCLC), but due to the development of resistance, the benefit has been limited. Toosendanin (TSN) has shown therapeutic effects on NSCLC; however, the role of TSN on CDDP sensitization in NSCLC remains unknown. The antitumor effects of TSN and CDDP sensitization mediated by TSN were explored. TSN was added in various amounts to measure dose- and time-dependent cytotoxicity. Intracellular CDDP was detected by high-performance liquid chromatography...
April 7, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29621308/acceptability-and-performance-of-a-directly-assisted-oral-hiv-self-testing-intervention-in-adolescents-in-rural-mozambique
#11
Jonas Hector, Mary-Ann Davies, Johanna Dekker-Boersema, Mussa Manuel Aly, Cassimo Charifo A Abdalad, Ernesto Belario Rafael Langa, Jochen Ehmer, Michael Andre Hobbins, Laura Frances Jefferys
INTRODUCTION: Whereas progress in HIV testing and treatment has been made globally, the UNAIDS goal of "90 90 90" is still out of sight in rural northern Mozambique. New strategies that promote testing in hard to reach groups will aid Mozambique's response to the HIV epidemic. HIV self-testing (HIVST) is recommended by the WHO as an additional approach to augment the HIV testing services available to adolescents. This study evaluates acceptability and performance of a directly assisted oral HIVST intervention for adolescents in rural Mozambique...
2018: PloS One
https://www.readbyqxmd.com/read/29615485/alpha-oscillations-are-causally-linked-to-inhibitory-abilities-in-ageing
#12
Giulia Borghini, Michela Candini, Cristina Filannino, Masud Hussain, Vincent Walsh, Vincenzo Romei, Nahid Zokaei, Marinella Cappelletti
Ageing adults typically show reduced ability to ignore task-irrelevant information, an essential skill for optimal performance in many cognitive operations, including those requiring working memory (WM) resources. In a first experiment, young and elderly human participants of both genders performed an established WM paradigm probing inhibitory abilities by means of valid, invalid and neutral retro-cues. Elderly participants showed an overall cost, especially in performing invalid trials while youngers' general performance was comparatively higher, as expected...
April 3, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29604838/study-of-homogeneous-bubble-nucleation-in-liquid-carbon-dioxide-by-a-hybrid-approach-combining-molecular-dynamics-simulation-and-density-gradient-theory
#13
K Langenbach, M Heilig, M Horsch, H Hasse
A new method for predicting homogeneous bubble nucleation rates of pure compounds from vapor-liquid equilibrium (VLE) data is presented. It combines molecular dynamics simulation on the one side with density gradient theory using an equation of state (EOS) on the other. The new method is applied here to predict bubble nucleation rates in metastable liquid carbon dioxide (CO2 ). The molecular model of CO2 is taken from previous work of our group. PC-SAFT is used as an EOS. The consistency between the molecular model and the EOS is achieved by adjusting the PC-SAFT parameters to VLE data obtained from the molecular model...
March 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29597251/-appropriate-treatment-and-therapeutic-window-in-spasticity-treatment-with-incobotulinumtoxina-from-100-to-1000-units
#14
Giancarlo Ianieri, Riccardo Marvulli, Giulia Alessia Gallo, Pietro Fiore, Marisa Megna
Many neurological diseases (ischemic and hemorrhagic stroke, multiple sclerosis, infant cerebral palsy, spinal cord injuries, traumatic brain injury, and other cerebrovascular disorders) may cause muscle spasticity. Different therapeutic strategies have been proposed for the treatment of spasticity. One of the major treatments for tone modulation is botulinum toxin type A (BTX-A), performed in addition to other rehabilitation strategies based on individualized multidisciplinary programs aimed at achieving certain goals for each patient...
March 28, 2018: Toxins
https://www.readbyqxmd.com/read/29581936/unsuccessful-xpert-%C3%A2-mtb-rif-results-the-nigerian-experience
#15
M Gidado, N Nwokoye, P Nwadike, P Ajiboye, R Eneogu, S Useni, J Onazi, A Lawanson, E Elom, A Tubi, J Kuye
Setting: Nigeria, a high tuberculosis (TB) burden country. Objective: To study the rate, distribution and causes of unsuccessful Xpert® MTB/RIF test outcomes, with the aim of identifying key areas that need to be strengthened for optimal performance of the assay. Design: This was a retrospective analysis of data uploaded between January and December 2015 from Xpert facilities to the central server using GXAlert. Result: Of 52 219 test results uploaded from 176 Xpert machines, 22.5% were positive for Mycobacterium tuberculosis, 10...
March 21, 2018: Public Health Action
https://www.readbyqxmd.com/read/29575608/the-association-between-reading-abilities-and-visual-spatial-attention-in-hong-kong-chinese-children
#16
Sisi Liu, Duo Liu, Zhihui Pan, Zhengye Xu
A growing body of research suggests that visual-spatial attention is important for reading achievement. However, few studies have been conducted in non-alphabetic orthographies. This study extended the current research to reading development in Chinese, a logographic writing system known for its visual complexity. Eighty Hong Kong Chinese children were selected and divided into poor reader and typical reader groups, based on their performance on the measures of reading fluency, Chinese character reading, and reading comprehension...
March 25, 2018: Dyslexia: the Journal of the British Dyslexia Association
https://www.readbyqxmd.com/read/29574253/probing-the-role-of-the-vestibular-system-in-motivation-and-reward-based-attention
#17
Elvio Blini, Caroline Tilikete, Alessandro Farnè, Fadila Hadj-Bouziane
The vestibular system has widespread connections in the central nervous system. Several activation loci following vestibular stimulations have been notably reported in deep, limbic areas that are otherwise difficult to reach and modulate in healthy subjects. Following preliminary evidence, suggesting that such stimulations might affect mood and affective processing, we wondered whether the vestibular system is also involved in motivation. Evolutionary accounts suggest that visuo-vestibular mismatches might have a role in preventing the search for and exploitation of goods that previously resulted in aversive reactions, as they would be a fine warning signal which follows the contact with or ingestion of noxious neurotoxins...
February 27, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29534996/low-sensitivity-urine-pregnancy-testing-to-assess-medical-abortion-outcome-a-systematic-review
#18
REVIEW
Elizabeth G Raymond, Tara Shochet, Hillary Bracken
OBJECTIVES: To summarize data on the accuracy and acceptability of a strategy for identifying ongoing pregnancy after medical abortion treatment using a low-sensitivity pregnancy test (LSPT). STUDY DESIGN: We searched PubMed to identify studies that evaluated the use of a single post-treatment LSPT for detection of ongoing pregnancy after treatment with mifepristone and misoprostol. We extracted, assessed, and summarized data from each study. RESULTS: We found 10 studies that evaluated 6 LSPTs with human chorionic gonadotropin detection thresholds of 1000, 1500, or 2000 mIU/ml...
March 10, 2018: Contraception
https://www.readbyqxmd.com/read/29532050/prevalence-of-invalid-performance-on-baseline-testing-for-sport-related-concussion-by-age-and-validity-indicator
#19
Christopher A Abeare, Isabelle Messa, Brandon G Zuccato, Bradley Merker, Laszlo Erdodi
Importance: Estimated base rates of invalid performance on baseline testing (base rates of failure) for the management of sport-related concussion range from 6.1% to 40.0%, depending on the validity indicator used. The instability of this key measure represents a challenge in the clinical interpretation of test results that could undermine the utility of baseline testing. Objectives: To determine the prevalence of invalid performance on baseline testing and to assess whether the prevalence varies as a function of age and validity indicator...
March 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29527481/behavioral-and-eeg-responses-to-social-evaluation-a-two-generation-family-study-on-social-anxiety
#20
Anita Harrewijn, Melle J W van der Molen, Irene M van Vliet, Renaud L M Tissier, P Michiel Westenberg
Social anxiety disorder is an invalidating psychiatric disorder characterized by extreme fear and avoidance of one or more social situations in which patients might experience scrutiny by others. The goal of this two-generation family study was to delineate behavioral and electrocortical endophenotypes of social anxiety disorder related to social evaluation. Nine families of patients with social anxiety disorder (their spouse and children, and siblings of these patients with spouse and children) performed a social judgment paradigm in which they believed to be evaluated by peers...
2018: NeuroImage: Clinical
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