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https://www.readbyqxmd.com/read/28797447/evaluation-of-the-xpert%C3%A2-hpv-assay-in-the-detection-of-human-papillomavirus-in-formalin-fixed-paraffin-embedded-oropharyngeal-carcinomas
#1
Maria Gabriella Donà, Francesca Rollo, Barbara Pichi, Giuseppe Spriano, Raul Pellini, Renato Covello, Edoardo Pescarmona, Giulia Fabbri, Manuela Scalfari, Tarik Gheit, Maria Benevolo
OBJECTIVES: The increasing incidence of HPV-related Oropharyngeal Squamous Cell Carcinoma (OPSCC) and the improved survival of HPV-positive OPSCC highlight the need for effective tools in evaluating HPV status on formalin-fixed paraffin-embedded (FFPE) cancers. To date, there is no agreement regarding the most appropriate method for HPV testing on FFPE materials. We aimed to investigate the performance of the Xpert® HPV assay (Cepheid) on crude lysates from OPSCC FFPE tissues. MATERIALS AND METHODS: Crude lysates were obtained by proteinase K digestion of FFPE tissues that had already been analyzed by the INNO-LiPA HPV assay and p16(ink4a) immunostaining...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28783375/errors-using-observational-methods-for-ergonomics-assessment-in-real-practice
#2
Jose-Antonio Diego-Mas, Jorge Alcaide-Marzal, Rocio Poveda-Bautista
OBJECTIVE: The degree in which practitioners use the observational methods for musculoskeletal disorder risks assessment correctly was evaluated. BACKGROUND: Ergonomics assessment is a key issue for the prevention and reduction of work-related musculoskeletal disorders in workplaces. Observational assessment methods appear to be better matched to the needs of practitioners than direct measurement methods, and for this reason, they are the most widely used techniques in real work situations...
August 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28770353/comparison-of-the-effect-between-pioglitazone-and-metformin-in-treating-patients-with-pcos-a-meta-analysis
#3
REVIEW
Yifeng Xu, Yanxiang Wu, Qin Huang
BACKGROUND: Pioglitazone was used to treat patients of PCOS in many researches, but the treatment has not been recognized by public or recommended by all the guidelines. METHOD: We conducted a meta-analysis of the related literatures to objectively evaluate the clinical effectiveness and safety by comparing pioglitazone with metformin administrated by PCOS patients. Searches were performed in Cochrane Library, EMBASE and PubMed (last updated December 2016). RESULTS: Eleven studies among 486 related articles were identified through searches...
August 2, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28769750/commentary-brain-networks-correlated-gene-expression-supports-synchronous-activity-in-brain-networks-science-348-1241-4
#4
Spiro P Pantazatos, Xinyi Li
A recent report claims that functional brain networks defined with resting-state functional magnetic resonance imaging (fMRI) can be recapitulated with correlated gene expression (i.e., high within-network tissue-tissue "strength fraction," SF) (Richiardi et al., 2015). However, the authors do not adequately control for spatial proximity. We replicated their main analysis, performed a more effective adjustment for spatial proximity, and tested whether "null networks" (i.e., clusters with center coordinates randomly placed throughout cortex) also exhibit high SF...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28768480/internet-and-social-network-users-profiles-in-renal-transplant-recipients-in-france
#5
Yosra Mouelhi, Marine Alessandrini, Vanessa Pauly, Bertrand Dussol, Stéphanie Gentile
BACKGROUND: The use of the Internet for searching and sharing health information and for health care interactions may have a great potential for Renal Transplant Recipients (RTR). This study aims to determine the characteristics associated with Internet and social network use in a representative sample of RTR at the time of their inclusion in the study. METHODS: Data of this cross-sectional design is retrieved from a longitudinal study conducted in five French kidney transplant centers in 2011, and included Renal Transplant Recipients aged 18 years with a functioning graft for at least 1 year...
August 3, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28755238/dissociating-the-capture-of-attention-from-saccade-activation-by-subliminal-abrupt-onsets
#6
Tobias Schoeberl, Ulrich Ansorge
Attentional capture and effects on saccade metrics by subliminal abrupt onset cues have been studied with peripheral cues at one out of several (two to four) display locations, swiftly followed by additional onsets at the other display locations. The lead time of the cue was too short to be seen. Here, we were interested in whether such subliminal onset cues influenced saccades primarily by way of attention or by way of direct saccade activation. In separate blocks, participants made speeded pro-saccades towards a black target or anti-saccades away from the target...
July 28, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28753875/islam-and-the-urinary-stoma-a-contemporary-theological-and-urological-dilemma
#7
Saiful Miah, Altaf Mangera, Nadir I Osman, Suresh Venugopal, James Catto, Derek Rosario
BACKGROUND: The prayer ritual is an essential component of Islam that requires entry into a state of physical purity (wudhu) through ablution, which is invalidated by voiding. An important dilemma for patients and surgeons may arise when a Muslim patient is counselled on cystectomy because of the belief by some that an incontinent urinary diversion will automatically invalidate their wudhu. OBJECTIVE: To determine if there are any religious barriers and implications for Muslim patients undergoing an incontinent urinary diversion...
July 13, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753613/adaptive-swarm-balancing-algorithms-for-rare-event-prediction-in-imbalanced-healthcare-data
#8
Jinyan Li, Lian-Sheng Liu, Simon Fong, Raymond K Wong, Sabah Mohammed, Jinan Fiaidhi, Yunsick Sung, Kelvin K L Wong
Clinical data analysis and forecasting have made substantial contributions to disease control, prevention and detection. However, such data usually suffer from highly imbalanced samples in class distributions. In this paper, we aim to formulate effective methods to rebalance binary imbalanced dataset, where the positive samples take up only the minority. We investigate two different meta-heuristic algorithms, particle swarm optimization and bat algorithm, and apply them to empower the effects of synthetic minority over-sampling technique (SMOTE) for pre-processing the datasets...
2017: PloS One
https://www.readbyqxmd.com/read/28750317/advantages-of-cooled-fiber-for-monitoring-laser-tissue-ablation-through-temporal-and-spectral-analysis-of-rf-ultrasound-signal-a-case-study
#9
Simona Granchi, Enrico Vannacci, Luca Breschi, Elena Biagi
The promising minimally invasive laser thermal therapy technique may be improved if thermal lesions induced into the tissue can be carefully monitored in extension and morphology during the treatment. According to results obtained in several recent experimentations, solutions that avoid tissue carbonization during the treatment have been proposed, in order to allow deeper and longer lasting light penetration in treated tissue and to reduce failures of the applicator tip and fiber optic, dangerous for patients...
July 19, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28750015/accuracy-of-self-collected-vaginal-dry-swabs-using-the-xpert-human-papillomavirus-assay
#10
Rosa Catarino, Pierre Vassilakos, Aline Bilancioni, Stéphanie Bougel, Meriem Boukrid, Ulrike Meyer-Hamme, Patrick Petignat
BACKGROUND: Polymerase chain reaction-based Xpert human papillomavirus (HPV) assay is a rapid test that detects high-risk HPV (hrHPV) infection. This point-of-care test is usually performed by collecting a cervical specimen in a vial of PreservCyt® transport medium. We compared HPV test positivity and accuracy between self-collected sample with a dry swab (s-DRY) versus physician-collected cervical sampling using a broom like brush and immediate immersion in PreservCyt (dr-WET). METHODS: In this cross-sectional study, we recruited 150 women ≥ 18 years old attending the colposcopy clinic in the University Hospital of Geneva...
2017: PloS One
https://www.readbyqxmd.com/read/28749997/difficulties-and-flaws-in-performing-accurate-determinations-of-zeta-potentials-of-metal-nanoparticles-in-complex-solutions-four-case-studies
#11
Sara Skoglund, Jonas Hedberg, Elena Yunda, Anna Godymchuk, Eva Blomberg, Inger Odnevall Wallinder
The zeta potential (ZP) is a parameter commonly used to characterize metal nanoparticles (NPs) in solution. Such determinations are for example performed in nanotoxicology since the ZP influences e.g. the interaction between cells and different biomolecules. Four case studies on different metal NPs (Cu and Zn NPs, and citrate capped Ag NPs) are presented in this study in order to provide guidance on how to accurately interpret and report ZP data. Solutions of high ionic strength (150 mM NaCl) induce a higher extent of particle agglomeration (elucidated with Ag NPs) when compared with conditions in 10 mM NaCl, which further complicates the prediction of the ZP due to e...
2017: PloS One
https://www.readbyqxmd.com/read/28742949/strategies-to-increase-the-efficacy-of-using-gut-microbiota-for-the-modulation-of-obesity
#12
REVIEW
J Li, M S Riaz Rajoka, D Shao, C Jiang, M Jin, Q Huang, H Yang, J Shi
Obesity is one of the most serious global public health challenges of the 21st century. The adjustment of gut microbiota is often recommended as an efficient strategy to treat obesity. This modulation of gut microbiota can be performed by many methods, including dietary intervention, antibiotic application, the use of prebiotics and probiotics, bariatric surgery and faecal microbiota transplantation. In most cases, positive effects have been observed in response to treatment, but invalid and even contrary effects have also been observed in some cases due to factors that are unrelated to intervention methods, such as genetic factors, patient age or gender, environmental microbiota, climate, geography and lifestyle...
July 25, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28731886/collegiate-student-athletes-with-history-of-adhd-or-academic-difficulties-are-more-likely-to-produce-an-invalid-protocol-on-baseline-impact-testing
#13
Lisa Manderino, John Gunstad
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) and other academically-relevant diagnoses have been suggested as modifiers of neurocognitive testing in sport-related concussion, such as Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT). These preexisting conditions may suppress ImPACT scores to the extent that they are indistinguishable from low scores because of poor effort. The present study hypothesized that student athletes with history of ADHD or academic difficulties produce lower ImPACT composite scores and are more likely to produce invalid protocols than those without such conditions...
July 14, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28717823/-interdisciplinary-pain-assessment-in-the-hospital-setting-merely-a%C3%A2-door-opener-to-multimodal-pain-therapy
#14
E Sens, M Mothes-Lasch, J F Lutz
BACKGROUND: Chronic pain is characterized by a complex interaction of somatic, mental and social factors. Assessing these factors in patients with chronic pain is vital during the diagnostic work-up and when making a structured treatment plan. Interdisciplinary pain assessment (ISA) is the most promising method to deal with these challenges. This article presents our experience in performing pain assessments in the hospital setting and also illustrates the characteristic features of chronic pain patients undergoing such assessments...
July 17, 2017: Der Schmerz
https://www.readbyqxmd.com/read/28701935/cardiorespiratory-fitness-is-associated-with-selective-attention-in-healthy-male-high-school-students
#15
Eivind Wengaard, Morten Kristoffersen, Anette Harris, Hilde Gundersen
Background: Previous studies have shown associations of physical fitness and cognition in children and in younger and older adults. However, knowledge about associations in high-school adolescents and young adults is sparse. Thus, the aim of this study was to evaluate the association of physical fitness, measured as maximal oxygen uptake ([Formula: see text]), muscle mass, weekly training, and cognitive function in the executive domains of selective attention and inhibitory control, in healthy male high-school students...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28696386/analytic-and-diagnostic-performances-of-human-papillomavirus-e6-e7-mrna-test-on-up-to-11-year-old-liquid-based-cervical-samples-a-biobank-based-longitudinal-study
#16
Roberta Zappacosta, Francesca Sablone, Lucia Pansa, Davide Buca, Danilo Buca, Sandra Rosini
Human Papillomavirus (HPV) E6/E7 mRNA test demonstrated high specificity in detecting HPV infections, but studies assessing its efficacy in terms of cancer risk stratification are lacking. Follow-up studies are arduous and expensive. Biobank would be the answer to the problem, although data investigating the effects of long-term storage on RNA preservation are still needed. We addressed these issues by retrieving 202 residual liquid-based cervical specimens, collected from 149 women attending cervical cancer screening during the years 2001-2012...
July 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28691413/diagnostic-challenges-in-celiac-disease
#17
REVIEW
Karol Kowalski, Agata Mulak, Maria Jasińska, Leszek Paradowski
Diagnosis of celiac disease in adults is currently based on serologic tests in combination with histopathological assessment of small intestinal biopsy specimens. High titers of celiac-specific antibodies in immunocompetent patients with villous atrophy in a good quality biopsy sample allow to state confident diagnosis. Relive of symptoms and histological improvement after embarking on a gluten free diet further support initial diagnosis. However, in some cases, these conditions are not fulfilled what requires critical evaluation of laboratory and histopathology results and consideration of other potential causes for observed pathologies...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28686635/visuo-spatial-cueing-in-children-with-differential-reading-and-spelling-profiles
#18
Chiara Banfi, Ferenc Kemény, Melanie Gangl, Gerd Schulte-Körne, Kristina Moll, Karin Landerl
Dyslexia has been claimed to be causally related to deficits in visuo-spatial attention. In particular, inefficient shifting of visual attention during spatial cueing paradigms is assumed to be associated with problems in graphemic parsing during sublexical reading. The current study investigated visuo-spatial attention performance in an exogenous cueing paradigm in a large sample (N = 191) of third and fourth graders with different reading and spelling profiles (controls, isolated reading deficit, isolated spelling deficit, combined deficit in reading and spelling)...
2017: PloS One
https://www.readbyqxmd.com/read/28683069/emotional-cue-validity-effects-the-role-of-neurocognitive-responses-to-emotion
#19
Samantha Denefrio, Akeesha Simmons, Amishi Jha, Tracy A Dennis-Tiwary
The beneficial effect of valid compared to invalid cues on attention performance is a basic attentional mechanism, but the impact of emotional content on cue validity is poorly understood. We tested whether the effect of cue validity on attention performance differed when cues were angry, happy, or neutral faces. Moreover, we used scalp-recorded event-related potentials (ERPs) reflecting the capture of early visual attention (P1, N170) to test whether effects were strengthened when neurocognitive responses to angry or happy cues were enhanced (larger P1 and N170 amplitudes)...
2017: PloS One
https://www.readbyqxmd.com/read/28681448/an-analysis-of-the-arccheck-mr-diode-array-s-performance-for-viewray-quality-assurance
#20
Steven T Ellefson, Wesley S Culberson, Bryan P Bednarz, Larry A DeWerd, John E Bayouth
The ArcCHECK-MR diode array utilizes a correction system with a virtual inclinometer to correct the angular response dependencies of the diodes. However, this correction system cannot be applied to measurements on the ViewRay MR-IGRT system due to the virtual inclinometer's incompatibility with the ViewRay's multiple simultaneous beams. Additionally, the ArcCHECK's current correction factors were determined without magnetic field effects taken into account. In the course of performing ViewRay IMRT quality assurance with the ArcCHECK, measurements were observed to be consistently higher than the ViewRay TPS predictions...
July 2017: Journal of Applied Clinical Medical Physics
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