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Catherine Hennechart-Collette, Sandra Martin-Latil, Audrey Fraisse, Sylvie Perelle
Noroviruses (NoV) are currently the most common cause of viral foodborne diseases and RT-qPCR is widely used for their detection in food because of its sensitivity, specificity and rapidity. The ISO/TS (15216-1, 15216-2) procedures for detecting NoV and HAV in high-risk food categories such as shellfish, bottled water and vegetables were published in 2013. Milk products are less implicated in foodborne viral outbreaks but they can be contaminated with fruit added to these products or by the food handler. Thus, the development of sensitive and reliable techniques for the detection of NoV in dairy products is needed to ensure the safety of these products...
February 2017: Food Microbiology
Matthias Claus, Renate Kimbel, Klaus Schöne, Stephan Letzel, Dirk-Matthias Rose
This study aims to assess serostatus and vaccination status of hepatitis A and B among staff at schools for the handicapped. We also wanted to investigate factors associated with serostatus, number of infections with hepatitis A/hepatitis B at work, and factors influencing being vaccinated or not. The cross-sectional study was carried out between August 2010 and August 2012 at 13 German schools for severely handicapped. Data were analyzed using blood samples, vaccination documents, and questionnaires. A total of 395 persons participated in our study (response: 59...
October 3, 2016: Journal of Medical Virology
Grazia Tosone, Silvia Mascolo, Roberto Bruni, Stefania Taffon, Michele Equestre, Maria Elena Tosti, Anna Rita Ciccaglione, Fiorella Martucci, Alfonso Liberti, Maria Donata Iannece, Raffaele Orlando
Hepatitis A virus is a widely occurring disease, with different prevalence rates between countries in the North and West and those in the South and East. In Italy endemicity is low/medium, but not homogeneously distributed: in the northern/central regions a large hepatitis A outbreak due to genotype IA, related to the consumption of contaminated mixed frozen berries, occurred between 2013 and 2014, whereas in southern Italian regions recurrent outbreaks of hepatitis A, due to the IB genotype, still result from consumption of raw seafood...
September 1, 2016: Le Infezioni in Medicina
Andrea Hettmann, Gabriella Juhász, Ágnes Dencs, Bálint Tresó, Erzsébet Rusvai, Éva Barabás, Mária Takács
A transfusion-associated hepatitis A outbreak was found in the first time in Hungary. The outbreak involved five cases. Parenteral transmission of hepatitis A is rare, but may occur during viraemia. Direct sequencing of nested PCR products was performed, and all the examined samples were identical in the VP1/2A region of the hepatitis A virus genome. HAV sequences found in recent years were compared and phylogenetic analysis showed that the strain which caused these cases is the same as that had spread in Hungary recently causing several hepatitis A outbreaks throughout the country...
September 23, 2016: Virus Genes
Majid Naderi, Mehran Karimi, Maryam Sadat Hosseini, Es Hagh Moradi, Morteza Shamsizadeh, Akbar Dorgalaleh
Factor XIII deficiency (FXIIID) is an extremely rare hemorrhagic disorder with a prevalence of 1/3-5 million. Management of disease is performed by fresh frozen plasma (FFP), Cryoprecipitate (CP) or FXIII concentrate (Fibrogammin P®). Our objective was to assess safety and effectiveness of Fibrogammin P® in patients with FXIIID. For this purpose we designed this long-term follow up study on a large group of patients with FXIIID. This prospective study was conducted on 213 patients with FXIIID since 2009 to 2013...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Analía Urueña, Jorge E González, Analía Rearte, María E Pérez Carrega, Rogelio Calli, María F Pagani, Andrea Uboldi, Rosalía Vicentín, Patricia Caglio, María C Cañero-Velasco, Angela Gentile, Margarita Ramonet, Carla Vizzotti
BACKGROUND: Single-dose Hepatitis A Virus (HAV) vaccination was implemented in all Argentinean children aged 12 months in 2005. Previous studies demonstrated high prevalence of protective antibody response 4 years following single dose vaccination. This study assessed long term seroprotection against HAV after vaccination. METHODS: Children who received one dose of HAV vaccine at 1 year of age at least six years before enrollment were included at five centers in Argentina between 2013 and 2014...
September 15, 2016: Pediatric Infectious Disease Journal
Bin Yang, Hang Gong, Chunyan Chen, Xiaoming Chen, Changqun Cai
We described a novel resonance light scattering (RLS) sensor for the specific recognition of trace quantities of Hepatitis A Virus (HAV); the sensor was based on a mussel-inspired hepatitis molecularly imprinted polymer. As a recognition element, polydopamine (PDA)-coated totivirus-imprinted polymer was introduced on the surface of SiO2 nanoparticles (virus-imprinted SiO2@PDA NPs) using an efficient one-step synthesis method. The target virus was selectively captured by the imprinted polymer films, thereby increasing the RLS intensity...
August 27, 2016: Biosensors & Bioelectronics
Roya Ghasemian, Farhang Babamahmoodi, Fatemeh Ahangarkani
BACKGROUND: Iraq is a highly endemic area for the prevalence of hepatitis A and annually hosts a large number of Iranian pilgrims, most of whom are susceptible to infection with the hepatitis A virus (HAV). OBJECTIVES: This study reports the health hazard of hepatitis A for Iranian pilgrims who go to holly Karbala from the Mazandaran province. PATIENTS AND METHODS: In this cross-sectional study, the data of all patients with acute hepatitis A admitted in the Razi teaching hospital from November 23, 2014 to January 24, 2015, with a history of recently returning from holly Karbala or being exposed to Karbala pilgrims, were registered...
June 2016: Hepatitis Monthly
Paula Andrea Báez, Carlos Mario Jaramillo, Lina Arismendi, Julio Cesar Rendón, Fabián Cortés-Mancera, Dioselina Peláez, María Mercedes González, Francisco Molina, María Cristina Navas
INTRODUCTION: Hepatitis A virus (HAV) is an important pathogen, typically transmitted via the faecal-oral route. The epidemiology of the infection is directly related to drinking water access and adequate disposal of sewage water.  OBJECTIVE: To determine the presence and identify the genotype of HAV in environmental samples from eight municipalities and two villages in Antioquia, northwestern Colombia.  MATERIALS AND METHODS: Three serial samplings were done between December, 2012, and April, 2014...
2016: Biomédica: Revista del Instituto Nacional de Salud
Orlando Mayorga, Silja Bühler, Veronika K Jaeger, Seraina Bally, Christoph Hatz, Gert Frösner, Ulrike Protzer, Pierre Van Damme, Matthias Egger, Christian Herzog
BACKGROUND:  Universal two-dose hepatitis A virus (HAV) vaccination of toddlers effectively controls hepatitis A. High vaccine costs impede, however, implementation in endemic countries. To test single-dose vaccination as a possible alternative, we initiated an observational, longitudinal study in Nicaragua, to assess protective effectiveness and - through challenge vaccination - humoral immune memory response. METHODS:  Following a 2003 serosurvey, 130 originally seronegative children received 2005 one dose virosomal HAV vaccine, followed by yearly serological and clinical assessments until 2012...
September 6, 2016: Journal of Infectious Diseases
Jiandong Shi, Jing Sun, Meini Wu, Haixuan Wang, Ningzhu Hu, Yunzhang Hu
Hepatitis A virus (HAV), the causative agent of acute hepatitis, grows slowly without causing any cytopathic effect (CPE) and lead to a persistent infection in the fibroblasts in vitro. miRNAs play a key role in the viral pathogenesis and virus-host interactions. In this study, the comprehensive miRNA expression profiles of HAV-infected and uninfected fibroblasts were investigated by sRNA-seq and validated by RT-qPCR. The results showed that a total of 94 miRNAs were differentially expressed during HAV infection, including 11 up-regulated miRNAs and 83 down-regulated miRNAs...
August 31, 2016: Infection, Genetics and Evolution
Haroldo Cid da Silva, Cristiane Pinheiro Pestana, Ricardo Galler, Marco Alberto Medeiros
The use of recombinant proteins may represent an alternative model to inactivated vaccines against hepatitis A virus (HAV). The present study aimed to express the VP1 protein of HAV in baculovirus expression vector system (BEVS). The VP1 was expressed intracellularly with molecular mass of 35 kDa. The VP1 was detected both in the soluble fraction and in the insoluble fraction of the lysate. The extracellular expression of VP1 was also attempted, but the protein remained inside the cell. To verify if hydrophobic characteristics would also be present in the HAV structural polyprotein, the expression of P1-2A protein was evaluated...
August 2016: Memórias do Instituto Oswaldo Cruz
Karla F Corral-Jara, Jorge L Trujillo-Ochoa, Mauricio Realpe, Arturo Panduro, Juan F Gómez-Leyva, Yvonne Rosenstein, Alexis Jose-Abrego, Sonia Roman, Nora A Fierro
We recently reported an immune-modulatory role of conjugated bilirubin (CB) in hepatitis A virus (HAV) infection. During this infection the immune response relies on CD4+ T lymphocytes (TLs) and it may be affected by the interaction of HAV with its cellular receptor (HAVCR1/TIM-1) on T cell surface. How CB might affect T cell function during HAV infection remains to be elucidated. Herein, in vitro stimulation of CD4+ TLs from healthy donors with CB resulted in a decrease in the degree of intracellular tyrosine phosphorylation and an increase in the activity of T regulatory cells (Tregs) expressing HAVCR1/TIM-1...
2016: Mediators of Inflammation
Marta P Baleva, Snejina Mihaylova, Petja Yankova, Iliana Atanasova, Milena Nikolova-Vlahova, Elissaveta Naumova
INTRODUCTION: Selective IgA deficiency (IgAD) is the most prevalent type of primary immune deficiencies, but partial IgA deficiency is even more common. Addison's disease is a rare condition associated with primary adrenal insufficiency due to infection or autoimmune destruction of the adrenals. The association between IgA deficiency and Addison's disease is very rare. CASE AND LABORATORY DATA: We observed a 22-year-old male patient with marked darkening of the skin, especially on the palms and areolae, jaundice on the skin and sclera, astheno-adynamia, hypotension (80/50 mm Hg), and pain in the right hypochondrium...
2016: Central-European Journal of Immunology
Ying Ye, Michael J Griffin
BACKGROUND: Vibration-induced white finger (VWF) is the vascular component of the hand-arm vibration syndrome (HAVS). Two tests have been standardised so as to assist the diagnosis of VWF: the measurement of finger rewarming times and the measurement of finger systolic blood pressures (FSBPs). OBJECTIVES: This study investigates whether the two tests distinguish between fingers with and without symptoms of whiteness and compares individual results between the two test methods...
October 2016: Occupational and Environmental Medicine
Sameer Rao, J S Mao, Salman Motlekar, Zhuang Fangcheng, Ganesh Kadhe
Changing epidemiology of Hepatitis A virus (HAV) has led to an increased susceptibility of adolescents and adults to the infection. Vaccination can remarkably reduce the incidence and associated morbidity of HAV infection. This review is focused on the safety and efficacy of H2 strain derived live attenuated Hepatitis A vaccine. We found the vaccine to be highly immunogenic with minimal or negligible safety issues. Moreover, a single dose of live attenuated vaccine persists a long term immune response and can be a preferred option for developing countries...
August 17, 2016: Human Vaccines & Immunotherapeutics
Elena Volchkova, Karina Umbetova, Olga Belaia, Maria Sviridova, Ludmila Dmitrieva, Daria Arutyunova, Dmitriy Chernishov, Ludmila Karan
We report a hepatitis A (HAV) and dengue virus (DENV) co-infection in Russian man who had been traveling to Dominican Republic. At admission to the hospital hemorrhagic and jaundice symptoms were observed in patient. PCR tests of blood serum and urine revealed RNA dengue virus type 3, HAV RNA, anti-HAV-IgM.
2016: IDCases
Monirath Hav, Sokha Eav, Nicole Heang, Pintuna Pich, Davy Lim, Vitou Leang, Aun Korn, Sanine Lay, Michel Pluot, Leangsim Kruy
Prevalence of Abnormal Cervical Cytology in HIVNegative Women Participating in a Cervical Cancer Screening Program in Calmette Hospital, Cambodia.
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Xiaoshu Zhang, Jing An, Aixia Tu, Xuefeng Liang, Fuqiang Cui, Hui Zheng, Yu Tang, Jianfeng Liu, Xuxia Wang, Ningjing Zhang, Hui Li
OBJECTIVE: Compare immune persistence from one dose of each of 3 different hepatitis A vaccines when given to school-age children: a domestic, live attenuated hepatitis A vaccine (H2 vaccine); a domestic inactivated hepatitis A vaccine (Healive®); and an imported, inactivated hepatitis A vaccine (Havrix®),. METHODS: School-age children were randomized into 1 of 4 groups to receive a single dose of a vaccine: H2 vaccine, Healive®, Havrix®, or hepatitis B vaccine [control]...
September 2016: Human Vaccines & Immunotherapeutics
Edvaldo F da Silva, Daniel F Mazo, Claudia P Oliveira, Roseane P Medeiros, Flair J Carrilho, Mário G Pessôa
UNLABELLED:  Background. Patients with chronic HCV infection and superinfection by hepatitis A virus (HAV) or hepatitis B virus (HBV) have higher morbidity and mortality when compared with those without HCV infection. Therefore, HAV and HBV active immunization has become mandatory in this population and hence their serological markers must be determined. The aim of this study was to evaluate the prevalence of serological markers of HAV and HBV infection in patients with chronic HCV. MATERIAL AND METHODS: One thousand chronic HCV patients at the University of São Paulo School of Medicine were evaluated for the prevalence of serological markers of HAV and HBV infection...
September 2016: Annals of Hepatology
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