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https://www.readbyqxmd.com/read/28816176/-severely-increased-serum-lipid-levels-in-diabetic-ketoacidosis-case-report
#1
Hrafnkell Stefansson, Kristinn Sigvaldason, Hilmar Kjartansson, Helga Águsta Sigurjonsdottir
Severe hypertriglyceridemia is a known, but uncommon complication of diabetic ketoacidosis. We discuss the case of a 23-year-old, previously healthy, woman who initially presented to the emergency department with abdominal pain. Grossly lipemic serum due to extremely high triglyceride (38.6 mmol/L) and cholesterol (23.2 mmol/L) levels were observed with a high blood glucose (23 mmol/L) and a low pH of 7.06 on a venous blood gas. She was treated successfully with fluids and insulin and had no sequale of pancreatitis or cerebral edema...
July 2017: Læknablađiđ
https://www.readbyqxmd.com/read/28814963/effects-of-a-liquid-high-fat-meal-on-postprandial-lipid-metabolism-in-type-2-diabetic-patients-with-abdominal-obesity
#2
Feng Wang, Huixia Lu, Fukang Liu, Huizhen Cai, Zhixiu Song, Fei Guo, Yulan Xie, Guofang Shu, Guiju Sun
BACKGROUND: Postprandial lipemia and lipoprotein lipase (LPL) activity play crucial roles in the pathogenesis of accelerated atherosclerosis. This study aimed to evaluate the postprandial lipid metabolism after the ingestion of a liquid high-fat meal in type 2 diabetic patients with abdominal obesity, and determine if the PvuII polymorphisms of LPL influence their postprandial lipid responses. METHODS: Serum glucose, insulin, triglycerides (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were measured in fasting and postprandial state at 0...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28811856/serum-betatrophin-levels-and-clinical-features-in-patients-with-poorly-controlled-type-2-diabetes
#3
Kohzo Takebayashi, Kenji Hara, Tomoko Terasawa, Rika Naruse, Mariko Suetsugu, Takafumi Tsuchiya, Toshihiko Inukai
BACKGROUND: Betatrophin is a hormone mainly secreted by the liver that influences lipid metabolisms. The main purposes of this study were to investigate the effect of canagliflozin (a sodium glucose transporter 2 inhibitor) on circulating betatrophin levels, and to investigate the correlation of various markers associated with glucose and lipid metabolisms with betatrophin in patients with poorly controlled type 2 diabetes. METHODS: Patients were randomly divided into a control group (n = 15) and a canagliflozin-treated group (n = 15)...
September 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28811692/experimental-validation-of-antidiabetic-and-antioxidant-potential-of-cassia-tora-l-an-indigenous-medicinal-plant
#4
Vishnu Kumar, Ranjana Singh, Farzana Mahdi, Abbas Ali Mahdi, Raj Kumar Singh
The present study was undertaken to evaluate antidiabetic and antioxidant activities of Cassia tora (C. tora) seeds extract against streptozotocin induced diabetes in experimental rats to scientifically validate its use against diabetes. Ethanolic extract of C. tora seeds extract and standard drug (glibenclamide) prepared in aqueous gum acacia (2 %, w/v) suspension and fed orally to streptozotocin induced male adult diabetic rats of Charles Foster strain for 15 days. Biochemical parameters in normal, diabetic control, standard (600 μg/kg bw p...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28807878/sex-dependent-changes-in-lipid-metabolism-ppar-pathways-and-micrornas-that-target-ppars-in-the-fetal-liver-of-rats-with-gestational-diabetes
#5
Daiana Fornes, Verónica White, Romina Higa, Florencia Heinecke, Evangelina Capobianco, Alicia Jawerbaum
Gestational diabetes mellitus (GDM) is a prevalent disease that impairs fetal metabolism and development. We have previously characterized a rat model of GDM induced by developmental programming. Here, we analyzed lipid content, the levels of the three PPAR isotypes and the expression of microRNAs that regulate PPARs expression in the liver of male and female fetuses of control and GDM rats on day 21 of pregnancy. We found increased levels of triglycerides and cholesterol in the livers of male fetuses of GDM rats compared to controls, and, oppositely, reduced levels of triglycerides, cholesterol, phospholipids and free fatty acids in the livers of female fetuses of GDM rats compared to controls...
August 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28800543/hypoglycemic-and-hypolipidemic-effects-of-aqueous-extract-of-phaseolus-vulgaris-pods-in-streptozotocin-diabetic-rats
#6
Mohammad Faisal Almuaigel, Mosaad A Seif, Hamad Waleed Albuali, Omar Alharbi, Amer Alhawash
The present investigation was carried out to evaluate the reduction potential of aqueous extract of casing of pods of phaseolus vulgaris in blood glucose and lipids levels among hyperglycemic streptozotocin (STZ)-induced rats. Oral administration of 150mg/kg of aqueous oral administration of aqueous pod extract of phaseolus vulgaris to diabetic rats for 40days resulted in a significant decrease in blood glucose (p<001), cholesterol (P<0.01) and triglycerides (P<0.01). In addition, glibenclamide reduced blood glucose, cholesterol and triglycerides...
August 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28799203/efficacy-and-safety-of-alirocumab-in-people-with-prediabetes-vs-those-with-normoglycaemia-at-baseline-a-pooled-analysis-of-10-phase-iii-odyssey-clinical-trials
#7
L A Leiter, D Müller-Wieland, M T Baccara-Dinet, A Letierce, R Samuel, B Cariou
AIM: To assess the lipid-lowering efficacy and safety of alirocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, in people with hypercholesterolaemia and prediabetes at baseline vs people with normoglycaemia at baseline in a pooled analysis of 10 ODYSSEY phase III trials. METHODS: People classified as having prediabetes had baseline HbA1c ≥39 mmol/mol (5.7%) and <48 mmol/mol (6.5%), or two baseline fasting plasma glucose values ≥5.6 mmol/l (100 mg/dl) but no more than one fasting plasma glucose value ≥7...
August 11, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28797406/ct-detected-growth-of-coronary-artery%C3%A2-calcification-in-asymptomatic-middle-aged-subjects-and-association-with-15-biomarkers
#8
Søren Zöga Diederichsen, Mette Hjortdal Grønhøj, Hans Mickley, Oke Gerke, Flemming Hald Steffensen, Jess Lambrechtsen, Niels Peter Rønnow Sand, Lars Melholt Rasmussen, Michael Hecht Olsen, Axel Diederichsen
OBJECTIVES: This study sought to determine the incidence and progression of coronary artery calcification (CAC) in asymptomatic middle-aged subjects and to evaluate the value of a broad panel of biomarkers in the prediction of CAC growth. BACKGROUND: CAC continues to be a major risk factor, but the value of biochemical markers in predicting CAC incidence and progression remains unresolved. METHODS: At baseline, 1,227 men and women underwent traditional risk assessment and a computed tomography (CT) scan to determine the CAC score...
August 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28797359/primary-prevention-of-cardiovascular%C3%A2-disease-in-diabetes-mellitus
#9
REVIEW
Jonathan D Newman, Arthur Z Schwartzbard, Howard S Weintraub, Ira J Goldberg, Jeffrey S Berger
Type 2 diabetes mellitus (T2D) is a major risk factor for cardiovascular disease (CVD), the most common cause of death in T2D. Yet, <50% of U.S. adults with T2D meet recommended guidelines for CVD prevention. The burden of T2D is increasing: by 2050, approximately 1 in 3 U.S. individuals may have T2D, and patients with T2D will comprise an increasingly large proportion of the CVD population. The authors believe it is imperative that we expand the use of therapies proven to reduce CVD risk in patients with T2D...
August 15, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28793934/statin-therapy-causes-gut-dysbiosis-in-mice-through-a-pxr-dependent-mechanism
#10
Jose A Caparrós-Martín, Ricky R Lareu, Joshua P Ramsay, Jörg Peplies, F Jerry Reen, Henrietta A Headlam, Natalie C Ward, Kevin D Croft, Philip Newsholme, Jeffery D Hughes, Fergal O'Gara
BACKGROUND: Statins are a class of therapeutics used to regulate serum cholesterol and reduce the risk of heart disease. Although statins are highly effective in removing cholesterol from the blood, their consumption has been linked to potential adverse effects in some individuals. The most common events associated with statin intolerance are myopathy and increased risk of developing type 2 diabetes mellitus. However, the pathological mechanism through which statins cause these adverse effects is not well understood...
August 9, 2017: Microbiome
https://www.readbyqxmd.com/read/28792710/effects-of-passive-smoking-on-glycemic-parameters-and-lipid-profiles-in-a-chinese-female-population
#11
Lijuan Gu, Jing Li, Gui Pan, Xiaojun Zhou, Jianmin Zhang, Xiaoyang Lai, Jianping Liu
BACKGROUND: The adverse effects of exposure to second-hand cigarette smoke on glucose and lipid parameters in women and the underlying mechanisms are not well understood. In this prospective community-based study, we examined the effects of passive smoking on glycemic parameters and lipid profiles in a Chinese female population. METHODS: Of 3197 healthy women enrolled (30 - 75 years), 2082 self-reported passive exposure to smoke (≥ 15 minutes/day, 3 days/week, > 1 year) and 1115 had no smoke exposure (control group)...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792545/contribution-of-independent-and-pleiotropic-genetic-effects-in-the-metabolic-syndrome-in-a-hypertensive-rat
#12
Man Chun John Ma, Janette M Pettus, Jessica A Jakoubek, Matthew G Traxler, Karen C Clark, Amanda K Mennie, Anne E Kwitek
Hypertension is a major risk factor for cardiovascular disease, Type 2 diabetes, and end organ failure, and is often found concomitant with disorders characteristic of the Metabolic Syndrome (MetS), including obesity, dyslipidemia, and insulin resistance. While the associated features often occur together, the pathway(s) or mechanism(s) linking hypertension in MetS are not well understood. Previous work determined that genetic variation on rat chromosome 17 (RNO17) contributes to several MetS-defining traits (including hypertension, obesity, and dyslipidemia) in the Lyon Hypertensive (LH) rat, a genetically determined MetS model...
2017: PloS One
https://www.readbyqxmd.com/read/28782412/gestational-weight-gain-in-obese-pregnancy-impact-on-maternal-and-foetal-metabolic-parameters-and-birthweight
#13
Karen L Lindsay, Lorraine Brennan, Ann Rath, Orla C Maguire, Thomas Smith, Fionnuala M McAuliffe
The aim of this prospective, observational study was to investigate the impact of gestational weight gain (GWG) among euglycaemic obese pregnant women on maternal and foetal metabolic parameters and neonatal outcome. Total GWG was recorded for 101 obese, non-diabetic women with a singleton pregnancy. At 28 weeks of gestation, fasting maternal blood samples were analysed for glucose, insulin, c-peptide and lipids. Cord bloods were collected at delivery for analysis of glucose, c-peptide and lipids. GWG (mean ± SD =10...
August 6, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28781162/outpatient-cardiac-rehabilitation-effects-on-patient-improvement-outcomes
#14
Fergus W Gardiner, Elizabeth Regan, Ezekiel U Nwose, Phillip T Bwititi, Judith Crockett, Lexin Wang
OBJECTIVE: To determine if the Cardiac rehabilitation (CR) program had positive effects on the patient medically as well as effects on pathological risk factors, functional capacity, and mental health; and the extent to which targets for blood pressure (BP) control in patients with hypertension (HT) and diabetes mellitus (DM) are achieved. METHODOLOGY: CR participant data was collected from 1st June 2014 until 31st December 2015 (19 months), which included: demographics, medical history, social history, medications, lipid profiles and anthropometric measurements...
July 27, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28774737/the-mechanism-of-diabetic-retinopathy-pathogenesis-unifying-key-lipid-regulators-sirtuin-1-and-liver-x-receptor
#15
Sandra S Hammer, Eleni Beli, Nermin Kady, Qi Wang, Kiana Wood, Todd A Lydic, Goldis Malek, Daniel R Saban, Xiaoxin X Wang, Sugata Hazra, Moshe Levi, Julia V Busik, Maria B Grant
Diabetic retinopathy (DR) is a complication secondary to diabetes and is the number one cause of blindness among working age individuals worldwide. Despite recent therapeutic breakthroughs using pharmacotherapy, a cure for DR has yet to be realized. Several clinical trials have highlighted the vital role dyslipidemia plays in the progression of DR. Additionally, it has recently been shown that activation of Liver X receptor (LXRα/LXRβ) prevents DR in diabetic animal models. LXRs are nuclear receptors that play key roles in regulating cholesterol metabolism, fatty acid metabolism and inflammation...
August 2017: EBioMedicine
https://www.readbyqxmd.com/read/28769070/il6r-haplotype-rs4845625-t-rs4537545-c-is-a-risk-factor-for-simultaneously-high-crp-ldl-and-apob-levels
#16
A A Arguinano, E Naderi, N C Ndiaye, M Stathopoulou, S Dadé, B Alizadeh, S Visvikis-Siest
Interleukin 6 receptor (IL-6R), mediating IL-6's biological functions, plays an important role in different diseases such as diabetes, obesity and cardio-vascular diseases. In this study, we investigated the effects of two single nucleotide polymorphisms (SNPs), within the IL-6R loci, previously associated with C-reactive protein (CRP) and coronary heart diseases risk, and with controversial effects on lipids traits: SNP rs4845625 and SNP rs4537545. The results showed that both investigated SNPs were antagonistically related with CRP levels; the minor rs4845625*T allele was associated with increased CRP levels (P-value=0...
August 3, 2017: Genes and Immunity
https://www.readbyqxmd.com/read/28768173/the-sustained-effects-of-a-dual-gip-glp-1-receptor-agonist-nnc0090-2746-in-patients-with-type-2-diabetes
#17
Juan Pablo Frias, Edward J Bastyr, Louis Vignati, Matthias H Tschöp, Christophe Schmitt, Klara Owen, Rune Haubo Christensen, Richard D DiMarchi
Unimolecular dual incretins derived from hybridized glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) sequences have demonstrated synergistic reduction of adiposity in animal models and reductions of hyperglycemia in short-duration human trials. Here, we extend the characterization of NNC0090-2746 (also known as RG7697), a fatty-acylated dual agonist possessing in vitro balanced GIPR and GLP-1R agonism. In this 12-week, randomized, placebo-controlled, double-blind phase 2a trial, patients with type 2 diabetes inadequately controlled with metformin received 1...
August 1, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28765779/effects-of-folic-acid-supplementation-on-serum-homocysteine-levels-lipid-profiles-and-vascular-parameters-in-post-menopausal-korean-women-with-type-2-diabetes-mellitus
#18
Aswathy Vijayakumar, Eun-Kyung Kim, Hyesook Kim, Young Ju Choi, Kap Bum Huh, Namsoo Chang
BACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications. SUBJECTS/METHODS: We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 µg of folic acid (400 µg twice a day) daily...
August 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28763895/-utility-of-hemoglobin-a1c-for-diagnosing-metabolic-syndrome-in-chinese-subjects-over-50-years-old
#19
S Lin, L Hu, X F Li, K Y Lin, P W Mu, L Y Zeng
Objective: To evaluate glycated hemoglobing A1c (HbA1c) in diagnosing metabolic syndrome (MS) in Chinese subjects aged over 50 years. Methods: A community-based cross-sectional survey was conducted between October 2010 and January 2011 in Shipai community, Guangzhou. A total of 1 494 subjects aged over 50 years were investigated. Questionnaire survey and physical examination were performed among all participants. Fasting blood samples were obtained to measure plasma glucose (FPG), blood lipids and HbA1c. MS was defined by the criteria of International Diabetes Federation (IDF), National Cholesterol Education Program-Adult Treatment Panel Ⅲ (ATP Ⅲ)(2005) and Chinese Diabetes Society (CDS), respectively...
July 25, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28761658/anagliptin-ameliorates-albuminuria-and-urinary-liver-type-fatty-acid-binding-protein-excretion-in-patients-with-type-2-diabetes-with-nephropathy-in-a-glucose-lowering-independent-manner
#20
Munehiro Kitada, Shin-Ichi Tsuda, Kazunori Konishi, Ai Takeda-Watanabe, Mizue Fujii, Keizo Kanasaki, Makoto Nishizawa, Atsushi Nakagawa, Daisuke Koya
OBJECTIVE: The objective of this study is to elucidate the effect of anagliptin on glucose/lipid metabolism and renoprotection in patients with type 2 diabetic nephropathy. METHODS: Twenty-five patients with type 2 diabetic nephropathy received anagliptin 200 mg/day for 24 weeks, and 20 patients who were switched to anagliptin from other dipeptidyl peptidase-4 (DPP-4) inhibitors were analyzed regarding primary and secondary endpoints. The primary endpoint was change in hemoglobin A1c (HbA1c) during treatment with anagliptin...
2017: BMJ Open Diabetes Research & Care
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