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Allopurinol

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https://www.readbyqxmd.com/read/29906649/identification-of-new-drug-like-compounds-from-millets-as-xanthine-oxidoreductase-inhibitors-for-treatment-of-hyperuricemia-a-molecular-docking-and-simulation-study
#1
Rajesh Kumar Pathak, Ayushi Gupta, Rohit Shukla, Mamta Baunthiyal
Xanthine oxidoreductase plays an important role in formation of uric acid and its regulation during purine catabolism. Uncontrolled expression of this enzyme is responsible for overproduction and deposition of uric acid in blood that is potentially injurious because it can breakdown DNA and protein molecules, triggering many diseases. Human Xanthine oxidoreductase (HsXOR) is considered to be a pharmacological target for the treatment of hyperuricemia. Many of the HsXOR-inhibitor drugs such as Febuxostat and Allopurinol are known to have significant adverse effects...
May 28, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29899669/effect-of-xanthine-oxidase-inhibition-on-arterial-stiffness-in-patients-with-chronic-heart-failure
#2
Manal M Alem, Abdullah M Alshehri, Peter Mb Cahusac, Matthew R Walters
Background: The xanthine oxidase inhibitor allopurinol improves endothelial function in different populations, including patients with chronic heart failure (CHF). Its effect on arterial stiffness parameters is less clear. We investigated the effect of short-term low-dose allopurinol therapy on arterial stiffness in Saudi patients with stable mild-moderate CHF. Methods: A prospective, randomized, double-blind, placebo-controlled study was performed on 73 patients with mild-moderate CHF...
2018: Clinical Medicine Insights. Cardiology
https://www.readbyqxmd.com/read/29899013/assessment-of-cardiovascular-risk-in-older-patients-with-gout-initiating-febuxostat-versus-allopurinol-a-population-based-cohort-study
#3
MaryAnn Zhang, Daniel H Solomon, Rishi J Desai, Eun Ha Kang, Jun Liu, Tuhina Neogi, Seoyoung C Kim
Background -Hyperuricemia and gout are associated with increased risk of cardiovascular disease (CVD). Xanthine oxidase inhibitors (XOI), allopurinol and febuxostat, are the mainstay of urate lowering treatment for gout and may have different effects on cardiovascular risk in patients with gout. Methods -Using U.S. Medicare claims data (2008-2013), we conducted a cohort study for comparative cardiovascular safety of initiating febuxostat versus allopurinol among gout patients aged ≥65 years. The primary outcome was a composite endpoint of hospitalization for myocardial infarction (MI) or stroke...
June 13, 2018: Circulation
https://www.readbyqxmd.com/read/29894789/l-arginine-and-allopurinol-supplementation-attenuates-inflammatory-mediators-in-human-osteoblasts-osteoarthritis-cells
#4
Jichao Li, Zeng Zhang, Xiaohan Huang
This study investigated the synergistic effects of l-arginine and allopurinol on antioxidant and inflammatory mediators in human osteoblasts-osteoarthritis (HOb-OA) cells. The cells were treated with allopurinol (50-150 mg/kg bwt) and l-arginine (50-150 mg/kg bwt) for 72 h. Cell viability, catalase, superoxide dismutase (SOD), glutathione peroxidase (Gpx), reduced glutathione (GSH), lipid peroxidation, and the inflammatory markers interleukin 6 (IL-6), interleukin 1β (IL-1β), nuclear factor κB (NF-κB) and tumor necrosis factor alpha (TNF-α) were measured...
June 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29893941/medication-adherence-among-gout-patients-initiated-allopurinol-a-retrospective-cohort-study-in-the-clinical-practice-research-datalink-cprd
#5
Lieke E J M Scheepers, Andrea M Burden, Ilja C W Arts, Bart Spaetgens, Patrick Souverein, Frank de Vries, Annelies Boonen
Objectives: When urate lowering therapy is indicated in patients with gout, medication adherence is essential. This study assesses non-persistence and non-adherence in patients with newly diagnosed gout, and identifies factors associated with poor medication adherence. Methods: A retrospective data analysis was performed within the UK Clinical Practice Research Datalink (1987-2014) among incident gout patients, aged ⩾40 years and starting allopurinol (n = 48 280)...
June 8, 2018: Rheumatology
https://www.readbyqxmd.com/read/29885976/the-association-of-gout-with-incident-giant-cell-arteritis-in-older-adults
#6
Jasvinder A Singh, John D Cleveland
OBJECTIVES: To assess whether gout is associated with a higher or lower risk of a new diagnosis of giant cell arteritis (GCA) in older adults, adjusting for known risk factors of GCA. METHODS: We used the 5% Medicare claims to conduct a multivariable Cox regression analyses to assess the association of gout with incident GCA in adults 65 years or older adjusting for age, gender, race (known risk factors for GCA) and Charlson-Romano comorbidity score, the use of medications for cardiovascular diseases (statins, beta-blockers, diuretics, ACE-inhibitors) and gout (allopurinol, febuxostat)...
June 7, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29882989/editorial-an-argument-for-low-dose-thiopurine-allopurinol-combination-use-as-first-line-therapy-in-inflammatory-bowel-disease
#7
EDITORIAL
A R Ansari, A Aziz
No abstract text is available yet for this article.
July 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29882984/editorial-an-argument-for-low-dose-thiopurine-allopurinol-combination-use-as-first-line-therapy-in-inflammatory-bowel-disease-authors-reply
#8
EDITORIAL
A B Friedman, M P Sparrow
No abstract text is available yet for this article.
July 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29880613/real-world-outcomes-and-management-strategies-for-venetoclax-treated-chronic-lymphocytic-leukemia-patients-in-the-united-states
#9
Anthony R Mato, Meghan Thompson, John N Allan, Danielle M Brander, John M Pagel, Chaitra S Ujjani, Brian T Hill, Nicole Lamanna, Frederick Lansigan, Ryan Jacobs, Mazyar Shadman, Alan P Skarbnik, Jeffrey J Pu, Paul M Barr, Alison R Sehgal, Bruce D Cheson, Clive S Zent, Hande H Tuncer, Stephen J Schuster, Peter V Pickens, Nirav N Shah, Andre Goy, Allison M Winter, Christine Garcia, Kaitlin Kennard, Krista Isaac, Colleen Dorsey, Lisa M Gashonia, Arun K Singavi, Lindsey E Roeker, Andrew Zelenetz, Annalynn Williams, Christina Howlett, Hanna Weissbrot, Naveed Ali, Sirin Khajavian, Andrea Sitlinger, Eve Tranchito, Joanna Rhodes, Joshua Felsenfeld, Neil Bailey, Bhavisha Patel, Timothy F Burns, Melissa Yacur, Mansi Malhotra, Jakub Svoboda, Richard R Furman, Chadi Nabhan
Venetoclax is a BCL2 inhibitor approved for 17p-deleted relapsed/refractory chronic lymphocytic leukemia with activity following kinase inhibitors. We conducted a multicenter retrospective cohort analysis of patients with CLL treated with venetoclax to describe outcomes, toxicities, and treatment selection following venetoclax discontinuation. A total of 141 chronic lymphocytic leukemia patients were included (98% relapsed/refractory). Median age at venetoclax initiation was 67 years (range 37-91), median prior therapies was 3 (0-11), 81% unmutated IGHV, 45% del(17p), and 26...
June 7, 2018: Haematologica
https://www.readbyqxmd.com/read/29879316/glut9-influences-uric-acid-concentration-in-patients-with-lesch-nyhan-disease
#10
Rosa J Torres, Juan G Puig
BACKGROUND: Patients with deficient hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity present hyperuricemia and/or hyperuricosuria, with a variable degree of neurological manifestations. Hyperuricemia in HPRT deficiency is due to uric acid overproduction and is frequently treated with allopurinol. Renal uric acid excretion is sharply increased in these patients. In recent years, several renal tubular urate transporter single nucleotide polymorphisms (SNPs), including those of the GLUT9, ABCG2 and URAT1 genes, have been described that influence the renal handling of uric acid and modulate serum urate levels...
June 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29875169/cardiovascular-safety-of-febuxostat-and-allopurinol
#11
(no author information available yet)
No abstract text is available yet for this article.
June 6, 2018: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/29869840/implications-of-the-cardiovascular-safety-of-febuxostat-and-allopurinol-in-patients-with-gout-and-cardiovascular-morbidities-cares-trial-and-associated-fda-public-safety-alert
#12
REVIEW
Hyon Choi, Tuhina Neogi, Lisa Stamp, Nicola Dalbeth, Robert Terkeltaub
Recently, the FDA issued a public safety alert, responding to results of the now-published Cardiovascular Safety of Febuxostat and Allopurinol in Patients With Gout and Cardiovascular Morbidities (CARES) trial. CARES showed no significant difference between allopurinol and febuxostat in the primary composite endpoint of cardiovascular (CV) events in subjects with gout and established cardiovascular comorbidities at baseline. However, there was significantly increased risk of cardiac and all-cause mortality with febuxostat...
June 5, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29869162/inhibiting-pnp-for-the-therapy-of-hyperuricemia-in-lesch-nyhan-disease-preliminary-in-vitro-studies-with-analogues-of-immucillin-g
#13
Gabriella Jacomelli, E Baldini, C Mugnaini, V Micheli, G Bernardini, A Santucci
Lesch-Nyhan disease (LND) is a rare X-linked genetic disorder, with complete hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency, uric acid (UA), hypoxanthine and xanthine accumulation, and a devastating neurologic syndrome. UA excess, causing renal failure, is commonly decreased by xanthine oxidoreductase (XOR) inhibitors, such as allopurinol, yielding a xanthine and hypoxanthine increase. Xanthine accumulation may result in renal stones, while hypoxanthine excess seems involved in the neurological disorder...
June 4, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29800753/analysis-of-hla-b-allelic-variation-and-interferon-gamma-elispot-responses-in-patients-with-severe-cutaneous-adverse-reactions-associated-with-drugs
#14
Jettanong Klaewsongkram, Chonlaphat Sukasem, Pattarawat Thantiworasit, Nithikan Suthumchai, Pawinee Rerknimitr, Papapit Tuchinda, Leena Chularojanamontri, Yuttana Srinoulprasert, Ticha Rerkpattanapipat, Kumutnart Chanprapaph, Wareeporn Disphanurat, Panlop Chakkavittumrong, Napatra Tovanabutra, Chutika Srisuttiyakorn
BACKGROUND: The prevention and confirmation of drug-induced severe cutaneous adverse reactions (SCARs) are difficult. OBJECTIVE: To determine the benefit of HLA-B allele pre-screening and the measurement of drug-specific interferon-gamma (IFN-γ) releasing cells in the prevention and identification of the culprit drug in SCAR patients. METHODS: A total of 160 SCAR patients were recruited from six university hospitals in Thailand over a 3-year period...
May 22, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29799494/side-effects-and-interactions-of-the-xanthine-oxidase-inhibitor-febuxostat
#15
REVIEW
Andreas Jordan, Ursula Gresser
The paper addresses the safety of febuxostat and summarizes reports on side effects and interactions of febuxostat published by the cut-off date (last day of literature search) of 20 March 2018. Publications on side effects and the interactions of febuxostat were considered. Information concerning the occurrence of side effects and interactions in association with the treatment with febuxostat was collected and summarized in the review. The incidence of severe side effects was much less frequent than mild side effects (1...
May 25, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29792516/budget-impact-of-adding-lesinurad-for-second-line-treatment-of-gout-a-us-health-plan-perspective
#16
Robert W Klein, Shaum Kabadi, Frank N Cinfio, Christopher A Bly, Douglas Ca Taylor, Keith A Szymanski
AIM: Estimate budget impact of adopting lesinurad as add-on to allopurinol for urate-lowering therapy in gout. METHODS: A budget impact model was developed for a US payer perspective, using a Markov model to estimate costs, survival and discontinuation in a one-million-member health plan. The population included patients failing first-line gout therapy, followed for 5 years. RESULTS: Incremental costs of adding lesinurad versus no lesinurad were US$241,907 and US$1,098,220 in first and fifth years, respectively...
May 24, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29786457/xanthine-oxidase-inhibitors-and-sepsis
#17
Maria Fátima de Paula Ramos, Alceni do Carmo Morais Monteiro de Barros, Clara Versolato Razvickas, Fernanda T Borges, Nestor Schor
Xanthine oxidase activation occurs in sepsis and results in the generation of uric acid (UrAc) and reactive oxygen species (ROS). We aimed to evaluate the effect of xanthine oxidase inhibitors (XOis) in rats stimulated with lipopolysaccharide (LPS). LPS (10 mg/kg) was administered intraperitoneally (i.p.) immediately after allopurinol (Alo, 2 mg/kg) or febuxostat (Feb, 1 mg/kg) every 24 h for 3 days. To increase UrAc levels, oxonic acid (Oxo) was administered by gavage (750 mg/kg per day) for 5 days...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29785684/impact-of-a-clinical-decision-support-system-for-drug-dosage-in-patients-with-renal-failure
#18
Sophie Desmedt, Anne Spinewine, Michel Jadoul, Séverine Henrard, Dominique Wouters, Olivia Dalleur
Background A clinical decision support system (CDSS) linked to the computerized physician order entry may help improve prescription appropriateness in inpatients with renal insufficiency. Objective To evaluate the impact on prescription appropriateness of a CDSS prescriber alert for 85 drugs in renal failure patients. Setting Before-after study in a 975-bed academic hospital. Method Prescriptions of patients with renal failure were reviewed during two comparable periods of 6 days each, before and after the implementation of the CDSS (September 2009 and 2010)...
May 21, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#19
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29772470/synthesis-molecular-docking-and-xanthine-oxidase-inhibitory-activity-of-5-aryl-1h-tetrazoles
#20
Itrat Fatima, Humaira Zafar, Khalid Mohammed Khan, Syed Muhammad Saad, Sumaira Javaid, Shahnaz Perveen, M Iqbal Choudhary
5-Aryl-1H-tetrazoles (1-24) were synthesized and screened for their xanthine oxidase (XO) inhibitory activity using allopurinol as standard inhibitor (IC50  = 2.0 ± 0.01 µM). Six compounds 3, 4, 5, 9, 21, and 24 exhibited significant to weak activities with IC50 values in the range of 7.4-174.2 µM. Active compounds were further subjected to kinetic and molecular docking studies to deduce their modes of inhibition, and to study their interactions with the protein (XO) at atomic level, respectively...
May 1, 2018: Bioorganic Chemistry
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