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https://www.readbyqxmd.com/read/29037012/medical-treatment-of-intracranial-atherosclerosis-an-update
#1
REVIEW
Jong S Kim, Oh Young Bang
For patients with symptomatic intracranial atherosclerosis (ICAS), antithrombotic agents are the mainstay of therapy. Anticoagulation (warfarin) is not widely used since it is not more effective than aspirin and carries a high risk of bleeding. New oral anticoagulants are showing promise, but their use has not been investigated in appropriate clinical trials. Since the recurrent stroke risk is high with aspirin monotherapy, dual antiplatelets are considered in the early stage of symptomatic ICAS. Based on the Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events (CHANCE) and Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) results, aspirin plus clopidogrel has been recommended...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29036845/sexual-concerns-after-spinal-cord-injury-an-update-on-management
#2
Marcalee Sipski Alexander, Carrie Mlynarczyk Aisen, Sterling Morrison Alexander, Mindy Lipson Aisen
BACKGROUND: Spinal Cord Injury (SCI) causes neurological impairment with resultant neurogenic sexual dysfunction which can compound preexisting psychological and medical sexual concerns. Understanding these concerns is important in managing the lifelong needs of persons with SCIs. OBJECTIVES: To provide an overview of the impact of SCI on sexuality along with a framework for treatment of sexual concerns. To briefly review male infertility and its treatments and pregnancy in females after SCI...
October 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29036756/acupuncture-or-acupressure-for-induction-of-labour
#3
REVIEW
Caroline A Smith, Mike Armour, Hannah G Dahlen
BACKGROUND: This is one of a series of reviews of methods of cervical ripening and labour induction. The use of complementary therapies is increasing. Women may look to complementary therapies during pregnancy and childbirth to be used alongside conventional medical practice. Acupuncture involves the insertion of very fine needles into specific points of the body. Acupressure is using the thumbs or fingers to apply pressure to specific points. The limited observational studies to date suggest acupuncture for induction of labour has no known adverse effects to the fetus, and may be effective...
October 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29036392/update-from-the-advisory-committee-on-immunization-practices
#4
Sean T O'Leary, David W Kimberlin
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Representatives from the American Academy of Pediatrics (Carrie L...
September 25, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29035883/association-between-allergies-and-hypercholesterolemia-a-systematic-review
#5
Sara Manti, Caterina Cuppari, Lucia Marseglia, Gabriella D'Angelo, Teresa Arrigo, Eloisa Gitto, Salvatore Leonardi, Carmelo Salpietro
BACKGROUND: There is controversy in the literature regarding the potential relationship between atopic predisposition (AP) and serum cholesterol levels. To this purpose, we reviewed human studies that investigated this possible link. METHODS: Following PRISMA guidelines, a literature search of PubMed and Science Direct for peer-reviewed journal articles in English from January 2003, with updates through to August 2016, was conducted. Relevant publications were reviewed that included pediatric and adult populations...
October 17, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29035425/inhaled-versus-systemic-corticosteroids-for-the-treatment-of-bronchopulmonary-dysplasia-in-ventilated-very-low-birth-weight-preterm-infants
#6
REVIEW
Sachin S Shah, Arne Ohlsson, Henry L Halliday, Vibhuti S Shah
BACKGROUND: This is an update of a review published in 2012. A related review "Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates" has been updated as well. Bronchopulmonary dysplasia (BPD) is a serious and common problem among very low birth weight infants, despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome. Due to their anti-inflammatory properties, corticosteroids have been widely used to treat or prevent BPD...
October 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29032765/recent-patent-advances-for-neurodegenerative-disorders-and-its-treatment
#7
Bhavna Kumar, Deepika Sharma
BACKGROUND: Neurodegenerative disorders are one of the common diseases that affect our society with tremendous medical and financial burdens. As a whole, neurodegeneration affects individuals of all ages, but becomes increasingly frequent with age, coming to affect a very large share of our elderly population which is severely affecting the patient, caregivers, and enormously increasing the financial burden of the nation. These diseases share a very complex nature, which often result from combined genetic, environment and pathogenic factors...
October 10, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29032732/a-personalized-week-to-week-updating-algorithm-to-improve-continuous-glucose-monitoring-performance
#8
Stamatina Zavitsanou, Joon Bok Lee, Jordan E Pinsker, Mei Mei Church, Francis J Doyle, Eyal Dassau
BACKGROUND: Continuous glucose monitoring (CGM) systems are increasingly becoming essential components in type 1 diabetes mellitus (T1DM) management. Current CGM technology requires frequent calibration to ensure accurate sensor performance. The accuracy of these systems is of great importance since medical decisions are made based on monitored glucose values and trends. METHODS: In this work, we introduce a calibration strategy that is augmented with a weekly updating feature...
October 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29031817/bcrp-abcg2-and-high-alert-medications-biochemical-pharmacokinetic-pharmacogenetic-and-clinical-implications
#9
REVIEW
Daiki Hira, Tomohiro Terada
The human breast cancer resistance protein (BCRP/ABCG2) is an ATP-binding cassette efflux transporter that uses ATP hydrolysis to expel xenobiotics from cells, including anti-cancer medications. It is expressed in the gastrointestinal tract, liver, kidney, and brain endothelium. Thus, ABCG2 functions as a tissue barrier to drug transport that strongly influences the pharmacokinetics of substrate medications. Genetic polymorphisms of ABCG2 are closely related to inter-individual variations in therapeutic performance...
October 12, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29031346/aging-with-spinal-cord-injury-an-update
#10
REVIEW
Joel E Frontera, Patrick Mollett
The 2016 National Spinal Cord Injury Statistical Center's Spinal Cord Injury (SCI) Facts and Figures reports approximately 17,000 new cases yearly, approximately 54 cases per million. The past 40 years has brought a significant change in patterns of injury. The average age has increased from 29 years in the 1970s to approximately 42 years currently; it is believed it has plateaued. Aging persons with SCI may have a higher risk of developing other medical complications. Studies report a perceived improvement in quality of life among persons with SCI with age, influenced by psychological, medical, and environmental factors...
November 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/29029359/a-probabilistic-network-for-the-diagnosis-of-acute-cardiopulmonary-diseases
#11
Alessandro Magrini, Davide Luciani, Federico M Stefanini
In this paper, the development of a probabilistic network for the diagnosis of acute cardiopulmonary diseases is presented in detail. A panel of expert physicians collaborated to specify the qualitative part, which is a directed acyclic graph defining a factorization of the joint probability distribution of domain variables into univariate conditional distributions. The quantitative part, which is a set of parametric models defining these univariate conditional distributions, was estimated following the Bayesian paradigm...
October 13, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/29029319/new-records-of-phlebotomine-sand-flies-diptera-psychodidae-from-the-state-of-alagoas-northeast-of-brazil
#12
Moises Thiago de Souza Freitas, Carlos Fernando Rocha Dos Santos, Edilberto Marinho de Andrade, Carlos Brisola Marcondes, Valdir de Queiroz Balbino, Felipe Arley Costa Pessoa
Phlebotomine sand flies are small insects of great medical importance. This study presents new records of phlebotomine sand flies, which augment the list of species, recorded in the state of Alagoas, Brazil. Sand flies were collected using CDC miniature light traps. Collections were made between November 2008 and April 2016, in 47 municipalities within the state of Alagoas. Twenty-seven thousand two-hundred forty-four sand flies were collected, representing 18 species in seven genera. Lutzomyia longipalpis was the predominant species (85...
October 4, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29028194/temporal-scalability-of-dynamic-volume-data-using-mesh-compensated-wavelet-lifting
#13
Wolfgang Schnurrer, Niklas Pallast, Thomas Richter, Andre Kaup
Due to their high resolution, dynamic medical 2D+t and 3D+t volumes from computed tomography (CT) and magnetic resonance tomography (MR) reach a size which makes them very unhandy for teleradiologic applications. A lossless scalable representation offers the advantage of a down-scaled version which can be used for orientation or previewing, while the remaining information for reconstructing the full resolution is transmitted on demand. The wavelet transform offers the desired scalability. A very high quality of the lowpass sub-band is crucial in order to use it as a down-scaled representation...
October 12, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29027078/dynamic-scheduling-for-veterans-health-administration-patients-using-geospatial-dynamic-overbooking
#14
Stephen Adams, William T Scherer, K Preston White, Jason Payne, Oved Hernandez, Mathew S Gerber, N Peter Whitehead
The Veterans Health Administration (VHA) is plagued by abnormally high no-show and cancellation rates that reduce the productivity and efficiency of its medical outpatient clinics. We address this issue by developing a dynamic scheduling system that utilizes mobile computing via geo-location data to estimate the likelihood of a patient arriving on time for a scheduled appointment. These likelihoods are used to update the clinic's schedule in real time. When a patient's arrival probability falls below a given threshold, the patient's appointment is canceled...
October 12, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29026838/tumor-necrosis-factor-alpha-antibodies-in-fistulizing-crohn-s-disease-an-updated-systematic-review-and-meta-analysis
#15
REVIEW
Pardis Zaboli, Mohammad Abdollahi, Shilan Mozaffari, Shekoufeh Nikfar
Medical treatment for fistulizing Crohn's disease (FCD) is changing rapidly over the time by the introduction of novel therapeutic medicines, while no global consensus is available. This study aims to accomplish a systematic review and meta-analysis on the efficacy of tumor necrosis factor-alpha antibodies (anti-TNF-α antibodies) versus placebo in FCD. A systematic review of published literature was carried out till December 2016, and a meta-analysis of identified studies was done. Data have been explored from PubMed, Scopus, Cochrane Library Database, and Web of Science...
July 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29025846/cohort-profile-for-the-mastermind-study-using-the-clinical-practice-research-datalink-cprd-to-investigate-stratification-of-response-to-treatment-in-patients-with-type-2-diabetes
#16
Lauren R Rodgers, Michael N Weedon, William E Henley, Andrew T Hattersley, Beverley M Shields
PURPOSE: This is a retrospective cohort study using observational data from anonymised primary care records. We identify and extract all patients with type 2 diabetes and associated clinical data from the Clinical Practice Research Datalink (CPRD) to inform models of disease progression and stratification of treatment. PARTICIPANTS: Data were extracted from CPRD on 8 August 2016. The initial data set contained all patients (n=313 485) in the database who had received a type 2 diabetes medication...
October 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025842/discrepancies-between-clinicaltrials-gov-recruitment-status-and-actual-trial-status-a-cross-sectional-analysis
#17
Christopher W Jones, Michelle R Safferman, Amanda C Adams, Timothy F Platts-Mills
OBJECTIVES: To determine the accuracy of the recruitment status listed on ClinicalTrials.gov as compared with the actual trial status. DESIGN: Cross-sectional analysis. SETTING: Random sample of interventional phase 2-4 clinical trials registered between 2010 and 2012 on ClinicalTrials.gov. PRIMARY OUTCOME MEASURE: For each trial which was listed within ClinicalTrials.gov as ongoing, two investigators performed a comprehensive literature search for evidence that the trial had actually been completed...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29024292/hepatic-cystic-echinococcosis-in-australia-an-update-on-diagnosis-and-management
#18
REVIEW
Ben Keong, Bruce Wilkie, Tom Sutherland, Adrian Fox
BACKGROUND: Echinococcosis is an uncommonly encountered zoonotic disease caused by the taeniid Echinococcus. The only endemic species in Australia, Echinococcus granulosus, forms cysts in the liver in 70% of cases. The aim of this study was to review the literature to provide an evidence-based narrative update on the diagnosis and management of hepatic cystic echinococcosis in Australia. METHODS: We reviewed the literature, utilizing multiple research databases and citation tracking...
October 11, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29023594/first-trimester-medication-abortion-practice-in-the-united-states-and-canada
#19
Heidi E Jones, Katharine O'Connell White, Wendy V Norman, Edith Guilbert, E Steve Lichtenberg, Maureen Paul
We conducted a cross-sectional survey of abortion facilities from professional networks in the United States (US, n = 703) and Canada (n = 94) to estimate the prevalence of medication abortion practices in these settings and to look at regional differences. Administrators responded to questions on gestational limits, while up to five clinicians per facility reported on 2012 medication abortion practice. At the time of fielding, mifepristone was not approved in Canada. 383 (54.5%) US and 78 (83.0%) Canadian facilities participated...
2017: PloS One
https://www.readbyqxmd.com/read/29020969/updates-on-cardiovascular-outcome-trials-in-diabetes
#20
REVIEW
Oliver Schnell, Lars Rydén, Eberhard Standl, Antonio Ceriello
In 2008 the Food and Drug Administration introduced a guidance for industry that requires the investigation of cardiovascular outcomes of glucose-lowering medications. Since then, an increasing number of cardiovascular outcome trials have been completed in diabetes patients with high cardiovascular risk for members of the SGLT-2 and DPP4 inhibitors and GLP-1 receptor agonist classes. The trials confirmed cardiovascular safety for all tested anti-hyperglycaemic drugs and, in addition empagliflozin, semaglutide and liraglutide could even reduce cardiovascular risk...
October 11, 2017: Cardiovascular Diabetology
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