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David jaffray

Caitlin Gillan, Meredith Giuliani, Nicole Harnett, Winnie Li, Laura A Dawson, Mary Gospodarowicz, David Jaffray
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Shawn Stapleton, Daniel Mirmilshteyn, Jinzi Zheng, Christine Allen, David A Jaffray
The heterogeneous intra-tumoral accumulation of liposomes is a critical determinant of their efficacy. Both the chaotic tumor microcirculation and elevated IFP are linked to the heterogeneous intra-tumoral distribution of nanotechnology-based drug delivery systems such as liposomes. In the present study, the relationship between tumor microcirculation, elevated IFP, and accumulation of nanoparticles was investigated through in vivo experimentation. This was accomplished by evaluation of the tumor microcirculation using dynamic contrast enhanced computed tomography (DCE-CT) and measurement of tumor IFP using a novel image-guided robotic needle placement system connected to the micro-CT scanner...
2016: Journal of Visualized Experiments: JoVE
Winnie Li, Young-Bin Cho, Steve Ansell, Normand Laperriere, Cynthia Ménard, Barbara-Ann Millar, Gelareh Zadeh, Paul Kongkham, Mark Bernstein, David A Jaffray, Caroline Chung
PURPOSE: The present study used cone beam computed tomography (CBCT) to measure the inter- and intrafraction uncertainties for intracranial stereotactic radiosurgery (SRS) using the Leksell Gamma Knife (GK). METHODS AND MATERIALS: Using a novel CBCT system adapted to the GK radiosurgery treatment unit, CBCT images were acquired immediately before and after treatment for each treatment session within the context of a research ethics board-approved prospective clinical trial...
September 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Marlee M Vandewouw, Dionne M Aleman, David A Jaffray
PURPOSE: Continuous dose delivery in radiation therapy treatments has been shown to decrease total treatment time while improving the dose conformity and distribution homogeneity over the conventional step-and-shoot approach. The authors develop an inverse treatment planning method for Gamma Knife® Perfexion™ that continuously delivers dose along a path in the target. METHODS: The authors' method is comprised of two steps: find a path within the target, then solve a mixed integer optimization model to find the optimal collimator configurations and durations along the selected path...
August 2016: Medical Physics
Yannan Nancy Dou, Michael Dunne, Huang Huang, Trevor Mckee, Martin C Chang, David A Jaffray, Christine Allen
Treatment efficacy of a heat-activated thermosensitive liposome formulation of cisplatin (CDDP), known as HTLC, was determined in xenograft models of non-small-cell lung carcinoma. The short-term impact of local hyperthermia (HT) on tumor morphology, microvessel density and local inflammatory response was also evaluated. The HTLC formulation in combination with local HT resulted in a significant advantage in therapeutic effect in comparison with free drug and a non-thermosensitive liposome formulation of CDDP (i...
June 16, 2016: Journal of Drug Targeting
Marco Carlone, Tony Tadic, Harald Keller, Mohammad Rezaee, David Jaffray
PURPOSE: The surface dose in radiotherapy is subject to the physical properties of the radiation beam and collimator. The purpose of this work is to investigate the manipulation of surface dose using magnetic fields produced with a resistive magnet. Better understanding of the feasibility and mechanisms of altered surface dose could have important clinical applications where the surface dose must be increased for therapeutic goals, or reduced to enhance the therapeutic benefit. METHODS: A resistive magnet capable of generating a peak magnetic field up to 0...
June 2016: Medical Physics
Sarfraz Ahmad, Abdulkader Hamad, Amit Bhalla, Sarah Turner, Birender Balain, David Jaffray
PURPOSE: Lumbar spinal stenosis in the presence of degenerative spondylolisthesis is generally treated by means of surgery. The role of lumbar decompression without fusion is not clear. Therefore, the aim of this study was to assess whether patients who undergo decompression alone have a favourable outcome without the need for a subsequent fusion. METHODS: This is a prospective cohort study with single blinding of 83 consecutive patients with lumbar stenosis and degenerative spondylolisthesis treated by decompression, without fusion, using a spinous process osteotomy...
June 7, 2016: European Spine Journal
Shawn Stapleton, David Jaffray, Michael Milosevic
The tumor microenvironment has an important influence on cancer biological and clinical behavior and radiation treatment (RT) response. However, RT also influences the tumor microenvironment in a complex and dynamic manner that can either reinforce or inhibit this response and the likelihood of long-term disease control in patients. It is increasingly evident that the interplay between RT and the tumor microenvironment can be exploited to enhance the accumulation and intra-tumoral distribution of nanoparticles, mediated by changes to the vasculature and stroma with secondary effects on hypoxia, interstitial fluid pressure (IFP), solid tissue pressure (STP), and the recruitment and activation of bone marrow-derived myeloid cells (BMDCs)...
June 1, 2016: Advanced Drug Delivery Reviews
Winnie Li, Gregory Bootsma, Oscar Von Schultz, Per Carlsson, Normand Laperriere, Barbara-Ann Millar, David Jaffray, Caroline Chung
UNLABELLED: OBJECTIVES : A non-invasive immobilization system consisting of a thermoplastic mask with image-guidance using cone-beam CT (CBCT) and infrared (IR) tracking has been developed to ensure minimal inter- and intra-fractional movement during Gamma Knife radiosurgery. Prior to clinical use for patients on a Gamma Knife, this study clinically evaluates the accuracy and stability of this novel immobilization system with image-guidance in patients treated with standard fractionated radiation therapy on a linear accelerator...
2016: Curēus
Karl Magtibay, Mohammadali Beheshti, Farbod Hosseyndoust Foomany, Stéphane Massé, Patrick F H Lai, Nima Zamiri, John Asta, Kumaraswamy Nanthakumar, David Jaffray, Sridhar Krishnan, Karthikeyan Umapathy
Current practices in studying cardiac arrhythmias primarily use electrical or optical surface recordings of a heart, spatially limited transmural recordings, and mathematical models. However, given that such arrhythmias occur on a 3D myocardial tissue, information obtained from such practices lack in dimension, completeness, and are sometimes prone to oversimplification. The combination of complementary Magnetic-Resonance Imaging (MRI)-based techniques such as Current Density Imaging (CDI) and Diffusion Tensor Imaging (DTI) could provide more depth to current practices in assessing the cardiac arrhythmia dynamics in entire cross sections of myocardium...
May 1, 2016: Computers in Biology and Medicine
Chun-Rong Wang, Javed Mahmood, Qin-Rong Zhang, Ali Vedadi, Jenny Warrington, Ning Ou, Robert G Bristow, David A Jaffray, Qing-Bin Lu
There is a compelling need to develop anticancer therapies that target cancer cells and tissues. Arising from innovative femtomedicine studies, a new class of non-platinum-based halogenated molecules (called FMD molecules) that selectively kill cancer cells and protect normal cells in treatments of multiple cancers has been discovered. This article reports the first observation of the radiosensitizing effects of such compounds in combination with ionizing radiation for targeted radiotherapy of a variety of cancers...
April 2016: Molecular Cancer Therapeutics
Winnie Li, David A Jaffray, Graham Wilson, Douglas Moseley
This work measured time taken to integrate image-guidance with CBCTs in routine clinical practice for patients treated between 2007 and 2010 across eight linear accelerators. 117,301 CBCTs from 4592 patients across thirteen disease sites were included. The mean image assessment decision time was 79s. Decision time was correlated with setup displacement magnitude.
April 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Sohyoung Her, David A Jaffray, Christine Allen
Gold nanoparticles (AuNPs) have emerged as novel radiosensitizers owing to their high X-ray absorption, synthetic versatility, and unique chemical, electronic and optical properties. Multi-disciplinary research performed over the past decade has demonstrated the potential of AuNP-based radiosensitizers, and identified possible mechanisms underlying the observed radiation enhancement effects of AuNPs. Despite promising findings from pre-clinical studies, the benefits of AuNP radiosensitization have yet to successfully translate into clinical practice...
December 19, 2015: Advanced Drug Delivery Reviews
Yannan N Dou, Robert A Weersink, Warren D Foltz, Jinzi Zheng, Naz Chaudary, David A Jaffray, Christine Allen
Liposomes have been employed as drug delivery systems to target solid tumors through exploitation of the enhanced permeability and retention (EPR) effect resulting in significant reductions in systemic toxicity. Nonetheless, insufficient release of encapsulated drug from liposomes has limited their clinical efficacy. Temperature-sensitive liposomes have been engineered to provide site-specific release of drug in order to overcome the problem of limited tumor drug bioavailability. Our lab has designed and developed a heat-activated thermosensitive liposome formulation of cisplatin (CDDP), known as HTLC, to provide triggered release of CDDP at solid tumors...
2015: Journal of Visualized Experiments: JoVE
Jing Zou, Francis Talbot, Alessandra Tata, Leonardo Ermini, Kresimir Franjic, Manuela Ventura, Jinzi Zheng, Howard Ginsberg, Martin Post, Demian R Ifa, David Jaffray, R J Dwayne Miller, Arash Zarrine-Afsar
A picosecond infrared laser (PIRL) is capable of cutting through biological tissues in the absence of significant thermal damage. As such, PIRL is a standalone surgical scalpel with the added bonus of minimal postoperative scar tissue formation. In this work, a tandem of PIRL ablation with electrospray ionization (PIR-LAESI) mass spectrometry is demonstrated and characterized for tissue molecular imaging, with a limit of detection in the range of 100 nM for reserpine or better than 5 nM for verapamil in aqueous solution...
December 15, 2015: Analytical Chemistry
James M P Stewart, Steve Ansell, Patricia E Lindsay, David A Jaffray
Advances in precision microirradiators for small animal radiation oncology studies have provided the framework for novel translational radiobiological studies. Such systems target radiation fields at the scale required for small animal investigations, typically through a combination of on-board computed tomography image guidance and fixed, interchangeable collimators. Robust targeting accuracy of these radiation fields remains challenging, particularly at the millimetre scale field sizes achievable by the majority of microirradiators...
December 7, 2015: Physics in Medicine and Biology
Jinzi Zheng, Stephan G Klinz, Raquel De Souza, Jonathan Fitzgerald, David A Jaffray
BACKGROUND: Non-invasive measurement of tumor hypoxia has demonstrated potential for the evaluation of disease progression, as well as prediction and assessment of treatment outcome. [(18)F]fluoroazomycin arabinoside (FAZA) positron emission tomography (PET) has been identified as a robust method for quantification of hypoxia both preclinically and clinically. The goal of this investigation was to evaluate the feasibility and value of repeated FAZA-PET imaging to quantify hypoxia in tumors that received multi-dose chemotherapy...
December 2015: EJNMMI Research
Indrin J Chetty, Mary K Martel, David A Jaffray, Stanley H Benedict, Stephen M Hahn, Ross Berbeco, James Deye, Robert Jeraj, Brian Kavanagh, Sunil Krishnan, Nancy Lee, Daniel A Low, David Mankoff, Lawrence B Marks, Daniel Ollendorf, Harald Paganetti, Brian Ross, Ramon Alfredo C Siochi, Robert D Timmerman, John W Wong
Radiation therapy is an effective, personalized cancer treatment that has benefited from technological advances associated with the growing ability to identify and target tumors with accuracy and precision. Given that these advances have played a central role in the success of radiation therapy as a major component of comprehensive cancer care, the American Society for Radiation Oncology (ASTRO), the American Association of Physicists in Medicine (AAPM), and the National Cancer Institute (NCI) sponsored a workshop entitled "Technology for Innovation in Radiation Oncology," which took place at the National Institutes of Health (NIH) in Bethesda, Maryland, on June 13 and 14, 2013...
November 1, 2015: International Journal of Radiation Oncology, Biology, Physics
Rifat Atun, David A Jaffray, Michael B Barton, Freddie Bray, Michael Baumann, Bhadrasain Vikram, Timothy P Hanna, Felicia M Knaul, Yolande Lievens, Tracey Y M Lui, Michael Milosevic, Brian O'Sullivan, Danielle L Rodin, Eduardo Rosenblatt, Jacob Van Dyk, Mei Ling Yap, Eduardo Zubizarreta, Mary Gospodarowicz
Radiotherapy is a critical and inseparable component of comprehensive cancer treatment and care. For many of the most common cancers in low-income and middle-income countries, radiotherapy is essential for effective treatment. In high-income countries, radiotherapy is used in more than half of all cases of cancer to cure localised disease, palliate symptoms, and control disease in incurable cancers. Yet, in planning and building treatment capacity for cancer, radiotherapy is frequently the last resource to be considered...
September 2015: Lancet Oncology
David A Jaffray, Felicia M Knaul, Rifat Atun, Cary Adams, Michael B Barton, Michael Baumann, Yolande Lievens, Tracey Y M Lui, Danielle L Rodin, Eduardo Rosenblatt, Julie Torode, Jacob Van Dyk, Bhadrasain Vikram, Mary Gospodarowicz
No abstract text is available yet for this article.
September 2015: Lancet Oncology
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