keyword
MENU ▼
Read by QxMD icon Read
search

David jaffray

keyword
https://www.readbyqxmd.com/read/29077574/monte-carlo-simulation-of-radiation-transport-and-dose-deposition-from-locally-released-gold-nanoparticles-labeled-with-111-in-177-lu-or-90-y-incorporated-into-tissue-implantable-depots
#1
Priscilla Lai, Zhongli Cai, Jean-Philippe Pignol, Eli Lechtman, Shahram Mashouf, Yijie Lu, Mitchell A Winnik, David A Jaffray, Raymond M Reilly
Permanent seed implantation (PSI) brachytherapy is a highly conformal form of radiation therapy but is challenged with dose inhomogeneity due to its utilization of low energy radiation sources. Gold nanoparticles (AuNP) conjugated with electron emitting radionuclides have recently been developed as a novel form of brachytherapy and can aid in homogenizing dose through physical distribution of radiolabeled AuNP when injected intratumorally (IT) in suspension. However, the distribution is unpredictable and precise placement of many injections would be difficult...
October 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28976913/monte-carlo-simulation-of-radiation-transport-and-dose-deposition-from-locally-released-gold-nanoparticles-labeled-with-sup-111-sup-in-sup-177-sup-lu-or-sup-90-sup-y-incorporated-into-tissue-implantable-depots
#2
Priscilla Lai, Zhongli Cai, Jean-Philippe Pignol, Eli Lechtman, Shahram Mashouf, Yijie Lu, Mitchell A Winnik, David A Jaffray, Raymond M Reilly
Permanent seed implantation (PSI) brachytherapy is a highly conformal form of radiation therapy but is challenged with dose inhomogeneity due to its utilization of low energy radiation sources. Gold nanoparticles (AuNP) conjugated with electron emitting radionuclides have recently been developed as a novel form of brachytherapy and can aid in homogenizing dose through physical distribution of radiolabeled AuNP when injected intratumorally (i.t.) in suspension. However, the distribution is unpredictable and precise placement of many injections would be difficult...
October 4, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28859933/evaluation-of-high-dose-volumetric-ct-to-reduce-inter-observer-delineation-variability-and-ptv-margins-for-prostate-cancer-radiotherapy
#3
Hamideh Alasti, Young-Bin Cho, Charles Catton, Alejandro Berlin, Peter Chung, Andrew Bayley, Aaron Vandermeer, Vickie Kong, David Jaffray
PURPOSE: The aim was to determine whether the enhanced soft tissue contrast provided by high-dose volumetric CT (HDVCT) can reduce inter-observer variability in delineating prostate compared to helical conventional CT (CCT) scans and 3T MRI scans for patients undergoing radical prostate cancer radiotherapy. Secondly, to quantify the potential PTV reduction with decreased inter-observer variability. MATERIALS AND METHODS: A 320 slice volumetric CT scanner was used...
October 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28764881/dosimetric-impact-of-intrafraction-changes-in-mr-guided-high-dose-rate-hdr-brachytherapy-for-prostate-cancer
#4
Alexandra Rink, Jette Borg, Anna Simeonov, Gerald O'Leary, Joelle Helou, Cynthia Ménard, Peter Chung, David A Jaffray, Alejandro Berlin
PURPOSE: To assess changes in implant and treatment volumes through the course of a prostate high-dose-rate brachytherapy procedure and their impact on plan quality metrics. METHODS AND MATERIALS: Sixteen MRI-guided high-dose-rate procedures included a post-treatment MR (ptMR) immediately after treatment delivery (135 min between MR scans). Target and organs at risk (OARs) were contoured, and catheters were reconstructed. The delivered treatment plan was applied to the ptMR image set...
July 29, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28760449/tumor-microenvironment-determines-response-to-a-heat-activated-thermosensitive-liposome-formulation-of-cisplatin-in-cervical-carcinoma
#5
Yannan N Dou, Naz Chaudary, Martin C Chang, Michael Dunne, Huang Huang, David A Jaffray, Michael Milosevic, Christine Allen
Significant heterogeneity in the tumor microenvironment of human cervical cancer patients is known to challenge treatment outcomes in this population. The current standard of care for cervical cancer patients is radiation therapy and concurrent cisplatin (CDDP) chemotherapy. Yet this treatment strategy fails to control loco-regional disease in 10-30% of patients. In order to improve the loco-regional control rate, a thermosensitive liposome formulation of CDDP (HTLC) was developed to increase local concentrations of drug in response to mild hyperthermia (HT)...
July 29, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28557630/the-exploitation-of-low-energy-electrons-in-cancer-treatment
#6
REVIEW
Mohammad Rezaee, Richard P Hill, David A Jaffray
Given the distinct characteristics of low-energy electrons (LEEs), particularly at energies less than 30 eV, they can be applied to a wide range of therapeutic modalities to improve cancer treatment. LEEs have been shown to efficiently produce complex molecular damage resulting in substantial cellular toxicities. Since LEEs are produced in copious amounts from high-energy radiation beam, including photons, protons and ions; the control of LEE distribution can potentially enhance the therapeutic radio of such beams...
August 2017: Radiation Research
https://www.readbyqxmd.com/read/28486217/fully-automated-treatment-planning-for-head-and-neck-radiotherapy-using-a-voxel-based-dose-prediction-and-dose-mimicking-method
#7
Chris McIntosh, Mattea Welch, Andrea McNiven, David A Jaffray, Thomas G Purdie
Recent works in automated radiotherapy treatment planning have used machine learning based on historical treatment plans to infer the spatial dose distribution for a novel patient directly from the planning image. We present a probabilistic, atlas-based approach which predicts the dose for novel patients using a set of automatically selected most similar patients (atlases). The output is a spatial dose objective, which specifies the desired dose-per-voxel, and therefore replaces the need to specify and tune dose-volume objectives...
July 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28453911/validation-of-biomechanical-deformable-image-registration-in-the-abdomen-thorax-and-pelvis-in-a-commercial-radiotherapy-treatment-planning-system
#8
Michael Velec, Joanne L Moseley, Stina Svensson, Björn Hårdemark, David A Jaffray, Kristy K Brock
PURPOSE: The accuracy of deformable image registration tools can vary widely between imaging modalities and specific implementations of the same algorithms. A biomechanical model-based algorithm initially developed in-house at an academic institution was translated into a commercial radiotherapy treatment planning system and validated for multiple imaging modalities and anatomic sites. METHODS: Biomechanical deformable registration (Morfeus) is a geometry-driven algorithm based on the finite element method...
July 2017: Medical Physics
https://www.readbyqxmd.com/read/28434799/improved-outcomes-with-dose-escalation-in-localized-prostate-cancer-treated-with-precision-image-guided-radiotherapy
#9
Hamid Raziee, Fabio Y Moraes, Jure Murgic, Melvin L K Chua, Melania Pintilie, Peter Chung, Cynthia Ménard, Andrew Bayley, Mary Gospodarowicz, Padraig Warde, Tim Craig, Charles Catton, Robert G Bristow, David A Jaffray, Alejandro Berlin
BACKGROUND AND PURPOSE: Dose-escalated radiotherapy (DE) improves outcomes in localized prostate cancer (PCa). The impact of DE in the context of image-guided radiotherapy (IGRT) remains unknown. Herein, we determined outcomes of three sequential cohorts treated with progressive DE-IGRT. MATERIALS AND METHODS: We analyzed data from 1998 to 2012. Patients treated with radical radiotherapy were included, with three sequential institutional schedules: (A) 75.6Gy, (B) 79...
June 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28211793/a-novel-field-emission-microscopy-method-to-study-field-emission-characteristics-of-freestanding-carbon-nanotube-arrays
#10
Yunhan Li, Yonghai Sun, David A Jaffray, John T W Yeow
Field emission (FE) uniformity and the mechanism of emitter failure of freestanding carbon nanotube (CNT) arrays have not been well studied due to the difficulty of observing and quantifying FE performance of each emitter in CNT arrays. Herein a field emission microscopy (FEM) method based on poly(methyl methacrylate) (PMMA) thin film is proposed to study the FE uniformity and CNT emitter failure of freestanding CNT arrays. FE uniformity of freestanding CNT arrays and different levels of FE current contributions from each emitter in the arrays are recorded and visualized...
April 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28164865/the-correction-of-time-and-temperature-effects-in-mr-based-3d-fricke-xylenol-orange-dosimetry
#11
Mattea L Welch, David A Jaffray
Previously developed MR-based three-dimensional (3D) Fricke-xylenol orange (FXG) dosimeters can provide end-to-end quality assurance and validation protocols for pre-clinical radiation platforms. FXG dosimeters quantify ionizing irradiation induced oxidation of Fe(2+) ions using pre- and post-irradiation MR imaging methods that detect changes in spin-lattice relaxation rates (R 1  =  [Formula: see text]) caused by irradiation induced oxidation of Fe(2+). Chemical changes in MR-based FXG dosimeters that occur over time and with changes in temperature can decrease dosimetric accuracy if they are not properly characterized and corrected...
April 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27904964/only-walking-matters-assessment-following-lumbar-stenosis-decompression
#12
S Budithi, Rohit Dhawan, Andrew Cattell, Birender Balain, David Jaffray
PURPOSE: Multiple outcome measures exist to evaluate the outcomes of spinal decompression surgery; however, these tend to be complex and are difficult to express to the patient pre-operatively to accurately guide their expectations. We present outcomes, in terms of walking distance measurement, of a prospective single surgeon series of 76 consecutive patients with spinal stenosis. METHODS: 76 patients (mean age 68.8 years; 48-91 years) had decompression surgery using spinous process osteotomy...
February 2017: European Spine Journal
https://www.readbyqxmd.com/read/27816408/assessment-of-organs-at-risk-contouring-practices-in-radiosurgery-institutions-around-the-world-the-first-initiative-of-the-oar-standardization-working-group
#13
Helena Sandström, Caroline Chung, Hidefumi Jokura, Michael Torrens, David Jaffray, Iuliana Toma-Dasu
BACKGROUND AND PURPOSE: This study was an initiative of the Organs-at-Risk Standardization Working Group for evaluating the current degree of variability in the clinical practice of contouring organs-at-risk (OAR) for radiosurgery planning. MATERIALS AND METHODS: Imaging datasets for typical lesions (cavernous sinus meningioma, vestibular schwannoma, pituitary adenoma) treated with Leksell Gamma Knife Perfexion were circulated to 12 centers. Observers were asked to contour the target and OARs as per their standard clinical practice...
November 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27779123/quantifying-hypoxia-in-human-cancers-using-static-pet-imaging
#14
Edward Taylor, Ivan Yeung, Harald Keller, Bradley G Wouters, Michael Milosevic, David W Hedley, David A Jaffray
Compared to FDG, the signal of (18)F-labelled hypoxia-sensitive tracers in tumours is low. This means that in addition to the presence of hypoxic cells, transport properties contribute significantly to the uptake signal in static PET images. This sensitivity to transport must be minimized in order for static PET to provide a reliable standard for hypoxia quantification. A dynamic compartmental model based on a reaction-diffusion formalism was developed to interpret tracer pharmacokinetics and applied to static images of FAZA in twenty patients with pancreatic cancer...
November 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27598801/image-guided-radiation-therapy-unlocking-the-future-through-knowledge-translation
#15
EDITORIAL
Caitlin Gillan, Meredith Giuliani, Nicole Harnett, Winnie Li, Laura A Dawson, Mary Gospodarowicz, David Jaffray
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27583578/spatial-measurements-of-perfusion-interstitial-fluid-pressure-and-liposomes-accumulation-in-solid-tumors
#16
Shawn Stapleton, Daniel Mirmilshteyn, Jinzi Zheng, Christine Allen, David A Jaffray
The heterogeneous intra-tumoral accumulation of liposomes is a critical determinant of their efficacy. Both the chaotic tumor microcirculation and elevated IFP are linked to the heterogeneous intra-tumoral distribution of nanotechnology-based drug delivery systems such as liposomes. In the present study, the relationship between tumor microcirculation, elevated IFP, and accumulation of nanoparticles was investigated through in vivo experimentation. This was accomplished by evaluation of the tumor microcirculation using dynamic contrast enhanced computed tomography (DCE-CT) and measurement of tumor IFP using a novel image-guided robotic needle placement system connected to the micro-CT scanner...
August 18, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27511857/the-use-of-cone-beam-computed-tomography-for-image-guided-gamma-knife-stereotactic-radiosurgery-initial-clinical-evaluation
#17
Winnie Li, Young-Bin Cho, Steve Ansell, Normand Laperriere, Cynthia Ménard, Barbara-Ann Millar, Gelareh Zadeh, Paul Kongkham, Mark Bernstein, David A Jaffray, Caroline Chung
PURPOSE: The present study used cone beam computed tomography (CBCT) to measure the inter- and intrafraction uncertainties for intracranial stereotactic radiosurgery (SRS) using the Leksell Gamma Knife (GK). METHODS AND MATERIALS: Using a novel CBCT system adapted to the GK radiosurgery treatment unit, CBCT images were acquired immediately before and after treatment for each treatment session within the context of a research ethics board-approved prospective clinical trial...
September 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27487871/robotic-path-finding-in-inverse-treatment-planning-for-stereotactic-radiosurgery-with-continuous-dose-delivery
#18
Marlee M Vandewouw, Dionne M Aleman, David A Jaffray
PURPOSE: Continuous dose delivery in radiation therapy treatments has been shown to decrease total treatment time while improving the dose conformity and distribution homogeneity over the conventional step-and-shoot approach. The authors develop an inverse treatment planning method for Gamma Knife® Perfexion™ that continuously delivers dose along a path in the target. METHODS: The authors' method is comprised of two steps: find a path within the target, then solve a mixed integer optimization model to find the optimal collimator configurations and durations along the selected path...
August 2016: Medical Physics
https://www.readbyqxmd.com/read/27310112/thermosensitive-liposomal-cisplatin-in-combination-with-local-hyperthermia-results-in-tumor-growth-delay-and-changes-in-tumor-microenvironment-in-xenograft-models-of-lung-carcinoma
#19
Yannan Nancy Dou, Michael Dunne, Huang Huang, Trevor Mckee, Martin C Chang, David A Jaffray, Christine Allen
Treatment efficacy of a heat-activated thermosensitive liposome formulation of cisplatin (CDDP), known as HTLC, was determined in xenograft models of non-small-cell lung carcinoma. The short-term impact of local hyperthermia (HT) on tumor morphology, microvessel density and local inflammatory response was also evaluated. The HTLC formulation in combination with local HT resulted in a significant advantage in therapeutic effect in comparison with free drug and a non-thermosensitive liposome formulation of CDDP (i...
November 2016: Journal of Drug Targeting
https://www.readbyqxmd.com/read/27277041/technical-note-enhancing-the-surface-dose-using-a-weak-longitudinal-magnetic-field
#20
Marco Carlone, Tony Tadic, Harald Keller, Mohammad Rezaee, David Jaffray
PURPOSE: The surface dose in radiotherapy is subject to the physical properties of the radiation beam and collimator. The purpose of this work is to investigate the manipulation of surface dose using magnetic fields produced with a resistive magnet. Better understanding of the feasibility and mechanisms of altered surface dose could have important clinical applications where the surface dose must be increased for therapeutic goals, or reduced to enhance the therapeutic benefit. METHODS: A resistive magnet capable of generating a peak magnetic field up to 0...
June 2016: Medical Physics
keyword
keyword
80641
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"