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David jaffray

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https://www.readbyqxmd.com/read/29273939/impact-of-tissue-transport-on-pet-hypoxia-quantification-in-pancreatic-tumours
#1
Edward Taylor, Jennifer Gottwald, Ivan Yeung, Harald Keller, Michael Milosevic, Neesha C Dhani, Iram Siddiqui, David W Hedley, David A Jaffray
BACKGROUND: The clinical impact of hypoxia in solid tumours is indisputable and yet questions about the sensitivity of hypoxia-PET imaging have impeded its uptake into routine clinical practice. Notably, the binding rate of hypoxia-sensitive PET tracers is slow, comparable to the rate of diffusive equilibration in some tissue types, including mucinous and necrotic tissue. This means that tracer uptake on the scale of a PET imaging voxel-large enough to include such tissue and hypoxic cells-can be as much determined by tissue transport properties as it is by hypoxia...
December 22, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29246584/serial-4dct-4dpet-imaging-to-predict-and-monitor-response-for-locally-advanced-non-small-cell-lung-cancer-chemo-radiotherapy
#2
Jean-Pierre Bissonnette, Mei Ling Yap, Katy Clarke, Andrea Shessel, Jane Higgins, Douglass Vines, Eshetu G Atenafu, Nathan Becker, Claudia Leavens, Andrea Bezjak, David A Jaffray, Alexander Sun
BACKGROUND AND PURPOSE: A FDG-PET/CT image feature with optimal prognostic potential for locally-advanced non-small cell lung cancer (LA-NSCLC) patients has yet to be identified, and neither has the optimal time for FDG-PET/CT response assessment; furthermore, nodal features have been largely ignored in the literature. We propose to identify image features or imaging time point with maximal prognostic power. MATERIALS AND METHODS: Consecutive consenting patients with LA-NSCLC receiving curative intent CRT were enrolled...
December 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29228390/altered-brain-morphology-after-focal-radiation-reveals-impact-of-off-target-effects-implications-for-white-matter-development-and-neurogenesis
#3
Kiran G Beera, Yu-Qing Li, Jun Dazai, James Stewart, Shannon Egan, Mashal Ahmed, C Shun Wong, David A Jaffray, Brian J Nieman
Background: Children with brain tumors treated with cranial radiation therapy (RT) often exhibit cognitive late effects, commonly associated with reduced white matter (WM) volume and decreased neurogenesis. The impact of radiation damage in particular regions or tissues on brain development as a whole has not been elucidated. Methods: We delivered whole-brain or focal radiation (8 Gy single dose) to infant mice. Focal treatments targeted white matter (anterior commissure), neuronal (olfactory bulbs), or neurogenic (subventricular zone) regions...
November 2, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29173909/voxel-by-voxel-correlation-between-radiologically-radiation-induced-lung-injury-and-dose-after-image-guided-intensity-modulated-radiotherapy-for-lung-tumors
#4
Michele Avanzo, Sara Barbiero, Marco Trovo, Jean-Pierre Bissonnette, Rajesh Jena, Joseph Stancanello, Giovanni Pirrone, Fabio Matrone, Emilio Minatel, Cristina Cappelletto, Carlo Furlan, David A Jaffray, Giovanna Sartor
PURPOSE: To correlate radiation dose to the risk of severe radiologically-evident radiation-induced lung injury (RRLI) using voxel-by-voxel analysis of the follow-up computed tomography (CT) of patients treated for lung cancer with hypofractionated helical Tomotherapy. METHODS AND MATERIALS: The follow-up CT scans from 32 lung cancer patients treated with various regimens (5, 8, and 25 fractions) were registered to pre-treatment CT using deformable image registration (DIR)...
October 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29173397/global-impact-of-radiotherapy-in-oncology-saving-one-million-lives-by-2035
#5
Yolande Lievens, Mary Gospodarowicz, Surbhi Grover, David Jaffray, Danielle Rodin, Julie Torode, Mei Ling Yap, Eduardo Zubizarreta
No abstract text is available yet for this article.
November 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29077574/monte-carlo-simulation-of-radiation-transport-and-dose-deposition-from-locally-released-gold-nanoparticles-labeled-with-111-in-177-lu-or-90-y-incorporated-into-tissue-implantable-depots
#6
Priscilla Lai, Zhongli Cai, Jean-Philippe Pignol, Eli Lechtman, Shahram Mashouf, Yijie Lu, Mitchell A Winnik, David A Jaffray, Raymond M Reilly
Permanent seed implantation (PSI) brachytherapy is a highly conformal form of radiation therapy but is challenged with dose inhomogeneity due to its utilization of low energy radiation sources. Gold nanoparticles (AuNP) conjugated with electron emitting radionuclides have recently been developed as a novel form of brachytherapy and can aid in homogenizing dose through physical distribution of radiolabeled AuNP when injected intratumorally (IT) in suspension. However, the distribution is unpredictable and precise placement of many injections would be difficult...
October 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28976913/monte-carlo-simulation-of-radiation-transport-and-dose-deposition-from-locally-released-gold-nanoparticles-labeled-with-sup-111-sup-in-sup-177-sup-lu-or-sup-90-sup-y-incorporated-into-tissue-implantable-depots
#7
Priscilla Lai, Zhongli Cai, Jean-Philippe Pignol, Eli Lechtman, Shahram Mashouf, Yijie Lu, Mitchell A Winnik, David A Jaffray, Raymond M Reilly
Permanent seed implantation (PSI) brachytherapy is a highly conformal form of radiation therapy but is challenged with dose inhomogeneity due to its utilization of low energy radiation sources. Gold nanoparticles (AuNP) conjugated with electron emitting radionuclides have recently been developed as a novel form of brachytherapy and can aid in homogenizing dose through physical distribution of radiolabeled AuNP when injected intratumorally (i.t.) in suspension. However, the distribution is unpredictable and precise placement of many injections would be difficult...
October 4, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28859933/evaluation-of-high-dose-volumetric-ct-to-reduce-inter-observer-delineation-variability-and-ptv-margins-for-prostate-cancer-radiotherapy
#8
Hamideh Alasti, Young-Bin Cho, Charles Catton, Alejandro Berlin, Peter Chung, Andrew Bayley, Aaron Vandermeer, Vickie Kong, David Jaffray
PURPOSE: The aim was to determine whether the enhanced soft tissue contrast provided by high-dose volumetric CT (HDVCT) can reduce inter-observer variability in delineating prostate compared to helical conventional CT (CCT) scans and 3T MRI scans for patients undergoing radical prostate cancer radiotherapy. Secondly, to quantify the potential PTV reduction with decreased inter-observer variability. MATERIALS AND METHODS: A 320 slice volumetric CT scanner was used...
October 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28764881/dosimetric-impact-of-intrafraction-changes-in-mr-guided-high-dose-rate-hdr-brachytherapy-for-prostate-cancer
#9
Alexandra Rink, Jette Borg, Anna Simeonov, Gerald O'Leary, Joelle Helou, Cynthia Ménard, Peter Chung, David A Jaffray, Alejandro Berlin
PURPOSE: To assess changes in implant and treatment volumes through the course of a prostate high-dose-rate brachytherapy procedure and their impact on plan quality metrics. METHODS AND MATERIALS: Sixteen MRI-guided high-dose-rate procedures included a post-treatment MR (ptMR) immediately after treatment delivery (135 min between MR scans). Target and organs at risk (OARs) were contoured, and catheters were reconstructed. The delivered treatment plan was applied to the ptMR image set...
July 29, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28760449/tumor-microenvironment-determines-response-to-a-heat-activated-thermosensitive-liposome-formulation-of-cisplatin-in-cervical-carcinoma
#10
Yannan N Dou, Naz Chaudary, Martin C Chang, Michael Dunne, Huang Huang, David A Jaffray, Michael Milosevic, Christine Allen
Significant heterogeneity in the tumor microenvironment of human cervical cancer patients is known to challenge treatment outcomes in this population. The current standard of care for cervical cancer patients is radiation therapy and concurrent cisplatin (CDDP) chemotherapy. Yet this treatment strategy fails to control loco-regional disease in 10-30% of patients. In order to improve the loco-regional control rate, a thermosensitive liposome formulation of CDDP (HTLC) was developed to increase local concentrations of drug in response to mild hyperthermia (HT)...
July 29, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28557630/the-exploitation-of-low-energy-electrons-in-cancer-treatment
#11
REVIEW
Mohammad Rezaee, Richard P Hill, David A Jaffray
Given the distinct characteristics of low-energy electrons (LEEs), particularly at energies less than 30 eV, they can be applied to a wide range of therapeutic modalities to improve cancer treatment. LEEs have been shown to efficiently produce complex molecular damage resulting in substantial cellular toxicities. Since LEEs are produced in copious amounts from high-energy radiation beam, including photons, protons and ions; the control of LEE distribution can potentially enhance the therapeutic radio of such beams...
August 2017: Radiation Research
https://www.readbyqxmd.com/read/28486217/fully-automated-treatment-planning-for-head-and-neck-radiotherapy-using-a-voxel-based-dose-prediction-and-dose-mimicking-method
#12
Chris McIntosh, Mattea Welch, Andrea McNiven, David A Jaffray, Thomas G Purdie
Recent works in automated radiotherapy treatment planning have used machine learning based on historical treatment plans to infer the spatial dose distribution for a novel patient directly from the planning image. We present a probabilistic, atlas-based approach which predicts the dose for novel patients using a set of automatically selected most similar patients (atlases). The output is a spatial dose objective, which specifies the desired dose-per-voxel, and therefore replaces the need to specify and tune dose-volume objectives...
July 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28453911/validation-of-biomechanical-deformable-image-registration-in-the-abdomen-thorax-and-pelvis-in-a-commercial-radiotherapy-treatment-planning-system
#13
Michael Velec, Joanne L Moseley, Stina Svensson, Björn Hårdemark, David A Jaffray, Kristy K Brock
PURPOSE: The accuracy of deformable image registration tools can vary widely between imaging modalities and specific implementations of the same algorithms. A biomechanical model-based algorithm initially developed in-house at an academic institution was translated into a commercial radiotherapy treatment planning system and validated for multiple imaging modalities and anatomic sites. METHODS: Biomechanical deformable registration (Morfeus) is a geometry-driven algorithm based on the finite element method...
July 2017: Medical Physics
https://www.readbyqxmd.com/read/28434799/improved-outcomes-with-dose-escalation-in-localized-prostate-cancer-treated-with-precision-image-guided-radiotherapy
#14
Hamid Raziee, Fabio Y Moraes, Jure Murgic, Melvin L K Chua, Melania Pintilie, Peter Chung, Cynthia Ménard, Andrew Bayley, Mary Gospodarowicz, Padraig Warde, Tim Craig, Charles Catton, Robert G Bristow, David A Jaffray, Alejandro Berlin
BACKGROUND AND PURPOSE: Dose-escalated radiotherapy (DE) improves outcomes in localized prostate cancer (PCa). The impact of DE in the context of image-guided radiotherapy (IGRT) remains unknown. Herein, we determined outcomes of three sequential cohorts treated with progressive DE-IGRT. MATERIALS AND METHODS: We analyzed data from 1998 to 2012. Patients treated with radical radiotherapy were included, with three sequential institutional schedules: (A) 75.6Gy, (B) 79...
June 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28211793/a-novel-field-emission-microscopy-method-to-study-field-emission-characteristics-of-freestanding-carbon-nanotube-arrays
#15
Yunhan Li, Yonghai Sun, David A Jaffray, John T W Yeow
Field emission (FE) uniformity and the mechanism of emitter failure of freestanding carbon nanotube (CNT) arrays have not been well studied due to the difficulty of observing and quantifying FE performance of each emitter in CNT arrays. Herein a field emission microscopy (FEM) method based on poly(methyl methacrylate) (PMMA) thin film is proposed to study the FE uniformity and CNT emitter failure of freestanding CNT arrays. FE uniformity of freestanding CNT arrays and different levels of FE current contributions from each emitter in the arrays are recorded and visualized...
April 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28164865/the-correction-of-time-and-temperature-effects-in-mr-based-3d-fricke-xylenol-orange-dosimetry
#16
Mattea L Welch, David A Jaffray
Previously developed MR-based three-dimensional (3D) Fricke-xylenol orange (FXG) dosimeters can provide end-to-end quality assurance and validation protocols for pre-clinical radiation platforms. FXG dosimeters quantify ionizing irradiation induced oxidation of Fe(2+) ions using pre- and post-irradiation MR imaging methods that detect changes in spin-lattice relaxation rates (R 1  =  [Formula: see text]) caused by irradiation induced oxidation of Fe(2+). Chemical changes in MR-based FXG dosimeters that occur over time and with changes in temperature can decrease dosimetric accuracy if they are not properly characterized and corrected...
April 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27904964/only-walking-matters-assessment-following-lumbar-stenosis-decompression
#17
S Budithi, Rohit Dhawan, Andrew Cattell, Birender Balain, David Jaffray
PURPOSE: Multiple outcome measures exist to evaluate the outcomes of spinal decompression surgery; however, these tend to be complex and are difficult to express to the patient pre-operatively to accurately guide their expectations. We present outcomes, in terms of walking distance measurement, of a prospective single surgeon series of 76 consecutive patients with spinal stenosis. METHODS: 76 patients (mean age 68.8 years; 48-91 years) had decompression surgery using spinous process osteotomy...
February 2017: European Spine Journal
https://www.readbyqxmd.com/read/27816408/assessment-of-organs-at-risk-contouring-practices-in-radiosurgery-institutions-around-the-world-the-first-initiative-of-the-oar-standardization-working-group
#18
Helena Sandström, Caroline Chung, Hidefumi Jokura, Michael Torrens, David Jaffray, Iuliana Toma-Dasu
BACKGROUND AND PURPOSE: This study was an initiative of the Organs-at-Risk Standardization Working Group for evaluating the current degree of variability in the clinical practice of contouring organs-at-risk (OAR) for radiosurgery planning. MATERIALS AND METHODS: Imaging datasets for typical lesions (cavernous sinus meningioma, vestibular schwannoma, pituitary adenoma) treated with Leksell Gamma Knife Perfexion were circulated to 12 centers. Observers were asked to contour the target and OARs as per their standard clinical practice...
November 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27779123/quantifying-hypoxia-in-human-cancers-using-static-pet-imaging
#19
Edward Taylor, Ivan Yeung, Harald Keller, Bradley G Wouters, Michael Milosevic, David W Hedley, David A Jaffray
Compared to FDG, the signal of (18)F-labelled hypoxia-sensitive tracers in tumours is low. This means that in addition to the presence of hypoxic cells, transport properties contribute significantly to the uptake signal in static PET images. This sensitivity to transport must be minimized in order for static PET to provide a reliable standard for hypoxia quantification. A dynamic compartmental model based on a reaction-diffusion formalism was developed to interpret tracer pharmacokinetics and applied to static images of FAZA in twenty patients with pancreatic cancer...
November 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27598801/image-guided-radiation-therapy-unlocking-the-future-through-knowledge-translation
#20
EDITORIAL
Caitlin Gillan, Meredith Giuliani, Nicole Harnett, Winnie Li, Laura A Dawson, Mary Gospodarowicz, David Jaffray
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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