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https://www.readbyqxmd.com/read/29332100/robot-assisted-radical-prostatectomy-is-more-beneficial-for-prostate-cancer-patients-a-system-review-and-meta-analysis
#1
Yuefeng Du, Qingzhi Long, Bin Guan, Lijun Mu, Juanhua Tian, Yumei Jiang, Xiaojing Bai, Dapeng Wu
BACKGROUND Robot-assisted radical prostatectomy (RARP) is increasingly used worldwide, but comparisons of perioperative, functional, and oncologic outcomes among RARP, laparoscopic radical prostatectomy (LRP), and open radical prostatectomy (ORP) remain inconsistent. MATERIAL AND METHODS Systematic literature searches were conducted using EMBASE, PubMed, the Cochrane Library, CNKI, and Science Direct/Elsevier up to April 2017. A meta-analysis was conducted using Review Manager and Stata software. RESULTS We included 33 studies...
January 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29327639/levels-of-uric-acid-in-erectile-dysfunction-of-different-aetiology
#2
Alessandra Barassi, Massimiliano Marco Corsi Romanelli, Raffaele Pezzilli, Elena Dozio, Clara Anna Linda Damele, Liborio Vaccalluzzo, Marco Di Dario, Giancarlo Goi, Nadia Papini, Luca Massaccesi, Giovanni Maria Colpi, Gian Vico Melzi d'Eril
Erectile dysfunction is a common disease characterized by endothelial dysfunction. The aetiology of ED is often multifactorial but evidence is being accumulated in favor of the proper function of the vascular endothelium that is essential to achieving and maintaining penile erection. Uric acid itself causes endothelial dysfunction via decreased nitric oxide production. This study aims to evaluate the serum uric acid (SUA) levels in 180 ED patients, diagnosed with the International Index of Erectile Function-5 (IIEF-5) and 30 non-ED control...
January 12, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29325831/sexual-dysfunction-among-young-men-overview-of-dietary-components-associated-with-erectile-dysfunction
#3
Ioannis Mykoniatis, Maria G Grammatikopoulou, Emmanouil Bouras, Efthalia Karampasi, Aikaterini Tsionga, Athanasios Kogias, Ioannis Vakalopoulos, Anna-Bettina Haidich, Michael Chourdakis
BACKGROUND: Sexual dysfunction is relatively common in young men, presenting in diverse manifestations, including erectile dysfunction (ED), for which dietary modifications, including increased intake of dietary antioxidants, have been suggested as promising and cost-efficient approaches. AIM: To assess the consumption of selected dietary antioxidants, in particular flavonoids, in relation to ED symptoms in young men. METHODS: Men 18 to 40 years old were invited to complete an anonymous web-based questionnaire for this case-control study...
January 8, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29325484/risk-of-erectile-dysfunction-after-traumatic-brain-injury-a-nationwide-population-based-cohort-study-in-taiwan
#4
Yun-Ju Yang, Wu-Chien Chien, Chi-Hsiang Chung, Kun-Ting Hong, Yi-Lin Yu, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Nian-Sheng Tzeng
INTRODUCTION: In our study, we aimed to investigate the association between a traumatic brain injury (TBI) and subsequent erectile dysfunction (ED). This is a population-based study using the claims dataset from The National Health Insurance Research Database. METHODS: We included 72,642 patients with TBI aged over 20 years, retrospectively, selected from the longitudinal health insurance database during 2000-2010, according to the ICD-9-CM. The control group consisted of 217,872 patients without TBI that were randomly chosen from the database at a ratio of 1:3, with age- and index year matched...
January 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29325456/dual-purpose-vardenafil-hydrochloride-dapoxetine-hydrochloride-orodispersible-tablets-in-vitro-formulation-evaluation-stability-study-and-in-vivo-comparative-pharmacokinetic-study-in-healthy-human-subjects
#5
Khaled El-Refaie, Mahmoud H Teaima, Mohamed A El-Nabarawi
Erectile Dysfunction (ED) is the most important disorder after premature ejaculation for sexual activity in men. Vardenafil Hydrochloride (VH) is an oral therapy for the treatment of erectile dysfunction. VH oral disintegrating tablets (ODTs) have been prepared by freeze drying technique to improve its dissolution profile and the overall clinical performance. Dapoxetine Hydrochloride (DH) was added to the best three formulae of the prepared VH ODTs to treat premature ejaculation. All the ODTs formulae were evaluated for weight variation, friability, drug content, in-vitro disintegration time, wetting time, and the dissolution study...
January 11, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29319919/outcomes-and-toxicities-in-intermediate-risk-prostate-cancer-patients-treated-with-brachytherapy-alone-or-brachytherapy-and-supplemental-external-beam-radiation-therapy
#6
Emily Schlussel Markovic, Michael Buckstein, Nelson N Stone, Richard G Stock
OBJECTIVE: To evaluate the cancer control outcomes and long-term treatment-related morbidity of brachytherapy as well as combination brachytherapy and EBRT in patients with intermediate-risk prostate cancer. MATERIALS AND METHODS: A retrospective review was conducted in a prospectively collected database of patients with intermediate-risk prostate cancer who were treated either with brachytherapy or brachytherapy and EBRT, with or without ADT, from 1990-2014. Urinary and erectile dysfunction symptoms are measured using the International Prostate Symptom Score (IPSS) and the Mount Sinai erectile function scale, and the Sexual Health Inventory for Men (SHIM), respectively...
January 10, 2018: BJU International
https://www.readbyqxmd.com/read/29319127/sexual-function-and-depressive-symptoms-in-young-men-with-hypothyroidism-receiving-levothyroxine-liothyronine-combination-therapy
#7
Robert Krysiak, Bogdan Marek, Bogusław Okopień
INTRODUCTION: Both overt and subclinical hypothyroidism are often accompanied by sexual dysfunction. Despite improving male sexual functioning, levothyroxine treatment does not always restore all its aspects. The aim of this study was to compare male sexual functioning and depressive symptoms between men with hypothyroidism receiving levothyroxine/liothyronine combination therapy and men receiving levothyroxine alone. MATERIAL AND METHODS: The study population consisted of 21 young levothyroxine-treated men with clinical symptoms of hypothyroidism in whom serum thyrotropin and thyroid hormone levels were within the normal limits...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29319007/calpain-inhibition-improves-erectile-function-in-diabetic-mice-via-upregulating-endothelial-nitric-oxide-synthase-expression-and-reducing-apoptosis
#8
Hao Li, Li-Ping Chen, Tao Wang, Shao-Gang Wang, Ji-Hong Liu
Calpain activation contributes to hyperglycemia-induced endothelial dysfunction and apoptosis. This study was designed to investigate the role of calpain inhibition in improving diabetic erectile dysfunction (ED) in mice. Thirty-eight-week-old male C57BL/6J mice were divided into three groups: (1) nondiabetic control group, (2) diabetic mice + vehicle group, and (3) diabetic mice + MDL28170 (an inhibitor of calpain) group. Type 1 diabetes was induced by intraperitoneal injection of streptozotocin at 60 mg kg-1 body weight for 5 consecutive days...
January 9, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29318970/physicochemical-characterization-and-skin-permeation-of-cationic-transfersomes-containing-the-synthetic-peptide-pnpp-19
#9
Flavia De Marco Almeida, Carolina Nunes Silva, Savia Caldeira de Araujo Lopes, Daniel Moreira Santos, Fernanda Silva Torres, Felipe Lima Cardoso, Patricia Massara Martinelli, Elizabeth Ribeiro da Silva, Maria Elena de Lima, Lucas Antonio Ferreira Miranda, Monica Cristina Oliveira
BACKGROUND: PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. OBJECTIVE: The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded transfersomes. METHOD: Three different liposomal preparation methods were evaluated. Cationic transfersomes contained egg phosphatidyl choline: stearylamine (9:1 w/w) and Tween 20 (84...
January 8, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29315457/evaluation-of-sex-hormones-and-sperm-parameters-in-male-epileptic-patients
#10
L Ocek, H Tarhan, F I Uludağ, A Sarıteke, C Köse, A Colak, F Zorlu, Y Zorlu
OBJECTIVES: The aim of this study was to investigate the effect of carbamazepine (CBZ) and sodium valproate (VPA) monotherapy on sexual functions, sex hormones, and semen analysis and quality in male patients with epilepsy. METHODS: A total of 59 male patients with epilepsy, of which 30 were on VPA monotherapy and 29 were on CBZ monotherapy, were included in the study between January 2015 and March 2016. A control group was established with 30 healthy males. Luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), free testosterone (fT), estradiol (E2), sex hormone-binding globulin (SHBG) levels and bioactive testosterone (BAT)/bioactive estradiol (BAE), and BAT/LH ratio were studied in groups...
January 7, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29306609/efficacy-and-safety-of-med2005-a-topical-glyceryl-trinitrate-formulation-in-the-treatment-of-erectile-dysfunction-a-randomized-crossover-study
#11
David J Ralph, Ian Eardley, Jorg Taubel, Paul Terrill, Tim Holland
BACKGROUND: Current treatments for erectile dysfunction (ED) have some limitations. AIM: This study evaluated the efficacy and tolerability of MED2005, a 0.2% glyceryl trinitrate topical gel, formulated into an enhanced absorption topical delivery system (DermaSys), administered on demand, in the treatment of ED. METHODS: This randomized, double-blinded, placebo-controlled, phase II crossover trial involved 232 men with ED (231 treated, 230 assessed for efficacy) and their partners...
December 29, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29299902/role-of-penile-prosthesis-in-priapism-a-review
#12
REVIEW
Amit G Reddy, Laith M Alzweri, Andrew T Gabrielson, Gabriel Leinwand, Wayne J G Hellstrom
Ischemic priapism is a urological emergency that has been associated with long-standing and irreversible adverse effects on erectile function. Studies have demonstrated a linear relationship between the duration of critically ischemic episodes and the subsequent development of corporal fibrosis and irreversible erectile function loss. Placement of a penile prosthesis is a well-established therapeutic option for the management of erectile dysfunction secondary to ischemic priapism, and will be the focus of this review...
January 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29299211/the-evaluation-of-relationship-between-sexual-self-concept-and-sexual-dysfunction-in-individuals-undergoing-methadone-maintenance-treatment
#13
Ghodratolah Rajabizadeh, Fatemeh Yazdanpanah, Mohammad Arash Ramezani
Background: The present study was conducted with the aim of designing a causal model for the evaluation of sexual dysfunctions based on the variables of methadone dosage and sexual self-concept among individuals undergoing methadone maintenance treatment (MMT). Methods: The study population of the present study consisted of married men of 20 to 45 years of age with sexual ýrelations and undergoing MMT for a minimum of 8 weeks referring to all MMT clinics of Kerman, Iran, in ýý2015-2016...
April 2017: Addiction & Health
https://www.readbyqxmd.com/read/29298510/structural-activity-relationship-of-ginsenosides-from-steamed-ginseng-in-the-treatment-of-erectile-dysfunction
#14
Ang Ying, Qing-Tao Yu, Li Guo, Wen-Song Zhang, Jin-Feng Liu, Yun Li, Hong Song, Ping Li, Lian-Wen Qi, Ya-Zhong Ge, E-Hu Liu, Qun Liu
Ginseng has been reported to have diverse pharmacological effects. One of the therapeutic claims for ginseng is to enhance sexual function. Ginsenosides are considered as the major active constituents. A steaming process can alter the ginsenoside profile of ginseng products. The structure-function relationship of ginsenosides in the treatment of erectile dysfunction (ED) has not been investigated yet. In this work, 15 different processed ginsengs are produced by steaming, and 13 major ginsensosides are quantified by liquid chromatography with UV detection, including Rg1, Re, Rf, Rb1, Rc, Rb2, Rf, Rk3, Rh4, 20S-Rg3, 20R-Rg3, Rk1, and Rg5...
January 3, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29289534/penile-length-measurement-technique-and-applications
#15
Ethan P Davoudzadeh, Natan P Davoudzadeh, Ezra Margolin, Peter J Stahl, Doron S Stember
INTRODUCTION: Penile size has long been an important fixation in men's lives. On the one hand, a smaller penis has been associated with anxiety and apprehension; on the other hand, a larger penis has generally been related to virility and strength. These perceptions predominate during an erection, when penile size is representative of a man's masculinity. AIM: To assess adult penile length and summarize average penile length assessments from the literature; analyze how various urologic diseases and therapies affect penile length and volume; and review how surgical treatments for Peyronie's disease, penile prosthesis implantation, and radical prostatectomy can affect penile size to appropriately counsel patients seeking such therapies and set realistic goals for patients...
December 27, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29288108/sexual-dysfunction-after-good-grade-aneurysmal-subarachnoid-hemorrhage
#16
Lorenz Epprecht, Michael Messerli, Robin Samuel, Martin Seule, Johannes Weber, Jean-Yves Fournier, Werner Surbeck
OBJECTIVE: Our aim was to assess the consequences of aneurysmal subarachnoid hemorrhage (aSAH) on sexual pleasure in patients with an otherwise favorable neurological outcome. METHODS: Anonymous, standardized questionnaires concerning sexual function, including the International Index of Erectile Function, Female Sexual Function Index, and a statement on subjective change in sexual pleasure after aSAH, were completed by 33 patients treated at the Cantonal Hospital St...
December 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29285284/activation-of-the-ngf-trka-signaling-pathway-attenuates-diabetic-erectile-dysfunction
#17
Yi Hou, Linpei Jia, Ying Zhang, Wei Ji, Hai Li
Erectile dysfunction (ED) is a common complication of diabetes mellitus (DM). The exact role of the NGF/TrkA signaling pathway in the pathogenesis of diabetic ED is largely unknown. In the present study, we investigated the role of the NGF/TrkA signaling pathway in Sprague-Dawley rats with diabetic ED. Animals were divided into 2 groups: the normal group and the DM ED model group. The model group included the blank subgroup, the negative control (NC) subgroup, the TrkA subgroup and the TrkA + NGF subgroup. Erectile function, intracavernous pressure (ICP) and mean arterial pressure were measured respectively...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29281341/functional-foods-and-nutraceuticals-as-dietary-intervention-in-chronic-diseases-novel-perspectives-for-health-promotion-and-disease-prevention
#18
Stephen Adeniyi Adefegha
Functional foods describe the importance of foods in promoting health and preventing diseases aside their primary role of providing the body with the required amount of essential nutrients such as proteins, carbohydrates, vitamins, fats, and oils needed for its healthy survival. This review explains the interaction of functional food bioactive compounds including polyphenols (phenolic acids [hydroxybenzoic acids and hydroxycinnamic acids], flavonoids [flavonols, flavones, flavanols, flavanones, isoflavones, proanthocyanidins], stilbenes, and lignans), terpenoids, carotenoids, alkaloids, omega-3 and polyunsaturated fatty acids, among others with critical enzymes (α- amylase, α- glucosidase, angiotensin-I converting enzyme [ACE], acetylcholinesterase [AChE], and arginase) linked to some degenerative diseases (type-2 diabetes, cardiovascular diseases [hypertension], neurodegenerative diseases [Alzheimer's disease] and erectile dysfunction)...
December 27, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29280463/cavernous-nerve-injury-by-radiation-therapy-may-potentiate-erectile-dysfunction-in-rats
#19
Javed Mahmood, Caroline Q Connors, Allen A Alexander, Radmila Pavlovic, Santanu Samanta, Sandrine Soman, Hotaka Matsui, Nikolai A Sopko, Trinity J Bivalacqua, Daniel Weinreich, Cheng-Ying Ho, John Eley, Amit Sawant, Isabel L Jackson, Zeljko Vujaskovic
PURPOSE/OBJECTIVES: Radiation-induced erectile-dysfunction (RiED) is one of the most common side effects of radiation therapy (RT) and significantly reduces the quality of life (QoL) of cancer patients. Approximately 50% of prostate cancer patients experience RiED within 3 to 5 years after completion of RT. A series of vascular, muscular, and neurogenic injuries after prostate RT lead to RiED; however, the precise role of RT-induced neurogenic injury in RiED has not been fully established...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29278308/effect-of-lysyl-oxidase-lox-on-corpus-cavernous-fibrosis-caused-by-ischaemic-priapism
#20
Liang Gao, Changjing Wu, Fudong Fu, Xuanhe You, Xue Ma, Feng Qin, Tao Li, Run Wang, Jiuhong Yuan
Penile fibrosis caused by ischemic priapism (IP) adversely affects patients' erectile function. We explored the role of lysyl oxidase (LOX) in rat and human penes after ischemic priapism (IP) to verify the effects of anti-LOX in relieving penile fibrosis and preventing erectile dysfunction caused by IP in rats. Seventy-two rats were randomly divided into six groups: control group, control + β-aminopropionitrile (BAPN) group, 9 hrs group, 9 hrs + BAPN group, 24 hrs group, and 24 hrs + BAPN group. β-aminopropionitrile (BAPN), a specific inhibitor of LOX, was administered in the drinking water...
December 26, 2017: Journal of Cellular and Molecular Medicine
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