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https://www.readbyqxmd.com/read/29148852/sildenafil-citrate-improves-the-delivery-and-anticancer-activity-of-doxorubicin-formulations-in-a-mouse-model-of-breast-cancer
#1
Khaled Greish, Maryam Fateel, Sara Abdelghany, Nanitha Rachel, Houman Alimoradi, Moiz Bakhiet, Ahmed Alsaie
Sildenafil is an approved drug for the treatment of erectile dysfunction. The drug exerts its action through the relaxation of smooth muscles and the modulation of vascular endothelial permeability. In this work, we tested whether the aforementioned effects of Sildenafil on tumor vasculatures could result in an improvement of anticancer drug concentration in tumor tissues, and hence improve its anticancer effect. Sildenafil when added to doxorubicin showed synergistic anticancer activity against 4T1 breast cancer cells in vitro...
November 17, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29148836/automatic-sex-liking-and-sex-failure-associations-in-men-with-sexual-dysfunction
#2
Jacques J D M van Lankveld, Peter J de Jong, Marcus J M J Henckens, Philip den Hollander, Anja J H C van den Hout, Peter de Vries
Current models of sexual functioning imply an important role for both automatic and controlled appraisals. Accordingly, it can be hypothesized that erectile dysfunction may be due to the automatic activation of negative appraisals at the prospect of sexual intercourse. However, previous research showed that men with sexual dysfunction exhibited relatively strong automatic sex-positive instead of sex-negative associations. This study tested the robustness of this unexpected finding and, additionally, examined the hypothesis that perhaps more specific sex-failure versus sex-success associations are relevant in explaining sexual dysfunction and distress...
November 17, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29147567/leriche-syndrome-the-inferior-mesenteric-artery-saves-the-lower-extremity
#3
Mahmoud Assaad, Sunit Tolia, Marcel Zughaib
Leriche syndrome presents as a triad of claudication, erectile dysfunction, and decreased distal pulses. This syndrome is a well-recognized entity in the current literature; however, our case report illustrates that even with a severe ostial lesion of the inferior mesenteric artery, the vessel was able to provide perfusion to bilateral lower extremities. The patient presented with symptoms of progressive pain in his right leg that limited his physical activity and he also complained of paresthesia, pallor, and cold skin with black discoloration of his toes bilaterally...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/29146233/statin-use-in-men-and-new-onset-of-erectile-dysfunction-a-systematic-review-and-meta-analysis
#4
Akram Y Elgendy, Islam Y Elgendy, Ahmed N Mahmoud, Mohammad Al-Ani, Mohamed M Moussa, Ahmad Mahmoud, Mohammad K Mojadidi, R David Anderson
Background Erectile dysfunction has been reported as an adverse effect of statin therapy. Methods We performed a meta-analysis of randomized trials and observational studies that compared statin users versus non-statin users and reported data regarding new onset of erectile dysfunction in men with established cardiovascular disease or cardiovascular disease risk factors. We used DerSimonian-Laird and Peto models to construct the summary estimates risk ratio (RR). We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) assessment to assess the overall quality of evidence for new onset erectile dysfunction...
November 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29145685/relation-between-monocyte-to-high-density-lipoprotein-cholesterol-ratio-and-presence-and-severity-of-erectile-dysfunction
#5
Mustafa Kadihasanoglu, Emre Karabay, Ugur Yucetas, Erkan Erkan, Emin Ozbek
Previous studies have evidenced that inflammation and endothelial dysfunction have a crucial role in erectile dysfunction (ED). Increased monocyte count or activity and lower high-density lipoprotein cholesterol (HDL-C) levels have been associated with inflammation. The monocyte to HDL-C ratio (MHR) is a recently emerged indicator of inflammation. We aimed to investigate the relationship between MHR and ED. In this retrospective study, a total of 120 patients were enrolled, 60 of them having ED and 60 having a normal erectile function...
November 16, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/29144914/re-factors-associated-with-erectile-dysfunction-and-the-peyronie-s-disease-questionnaire-in-patients-with-peyronie-disease
#6
Allen D Seftel
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29144912/re-does-any-association-exist-between-chronic-obstructive-pulmonary-disease-and-erectile-dysfunction-the-decoded-study
#7
Allen D Seftel
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29142443/oral-health-and-erectile-dysfunction
#8
REVIEW
Vijendra P Singh, Sunil K Nettemu, Sowmya Nettem, Rajesh Hosadurga, Sangeeta U Nayak
Ample evidence strongly supports the fact that periodontal disease is a major risk factor for various systemic diseases namely cardio-vascular disease, diabetes mellitus, etc. Recently, investigators focussed on exploring the link between chronic periodontitis (CP) and erectile dysfunction (ED) by contributing to the endothelial dysfunction. Both the diseases share common risk factors. Various studies conducted in different parts of the world in recent years reported the evidence linking this relationship as well as improvement in ED with periodontal treatment...
July 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29138981/young-men-who-have-sex-with-men-at-high-risk-for-hiv-bangkok-msm-cohort-study-thailand-2006-2014
#9
Warunee Thienkrua, Frits van Griensven, Philip A Mock, Eileen F Dunne, Boonyos Raengsakulrach, Wipas Wimonsate, Nopporn Howteerakul, Chaiwat Ungsedhapand, Anupong Chiwarakorn, Timothy H Holtz
High HIV incidence has been reported in young men who have sex with men (YMSM) in North America and Western Europe, but there are limited data from Southeast Asia suggesting MSM may be the driver of the HIV epidemic in this region. We described HIV incidence and risk factors among 494 YMSM enrolled in a cohort study in Bangkok, Thailand. The HIV incidence was 7.4 per 100 person-years. In multivariable analysis, reporting use of an erectile dysfunction drug in combination with club drugs, having receptive or both insertive and receptive anal intercourse with men, having hepatitis A infection, having rectal Chlamydia trachomatis, having hepatitis B infection prior to HIV seroconversion, and reporting not always using condoms with male steady partners were significantly associated with HIV incidence in YMSM...
November 14, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29136091/clinical-presentation-and-prognosis-in-mog-antibody-disease-a-uk-study
#10
Maciej Jurynczyk, Silvia Messina, Mark R Woodhall, Naheed Raza, Rosie Everett, Adriana Roca-Fernandez, George Tackley, Shahd Hamid, Angela Sheard, Gavin Reynolds, Saleel Chandratre, Cheryl Hemingway, Anu Jacob, Angela Vincent, M Isabel Leite, Patrick Waters, Jacqueline Palace
A condition associated with an autoantibody against MOG has been recently recognized as a new inflammatory disease of the central nervous system, but the disease course and disability outcomes are largely unknown. In this study we investigated clinical characteristics of MOG-antibody disease on a large cohort of patients from the UK. We obtained demographic and clinical data on 252 UK patients positive for serum immunoglobulin G1 MOG antibodies as tested by the Autoimmune Neurology Group in Oxford. Disability outcomes and disease course were analysed in more detail in a cohort followed in the Neuromyelitis Optica Oxford Service (n = 75), and this included an incident cohort who were diagnosed at disease onset (n = 44)...
November 9, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29135645/phosphodiesterase-type-5-inhibitors-sport-and-doping
#11
Luigi Di Luigi, Massimiliano Sansone, Andrea Sansone, Roberta Ceci, Guglielmo Duranti, Paolo Borrione, Clara Crescioli, Paolo Sgrò, Stefania Sabatini
Phosphodiesterase type 5 inhibitors (PDE5i) (e.g., sildenafil, tadalafil, vardenafil, and avanafil) are drugs commonly used to treat erectile dysfunction, pulmonary arterial hypertension, and benign prostatic hyperplasia. PDE5i are not prohibited by the World Anti-Doping Agency (WADA) but are alleged to be frequently misused by healthy athletes to improve sporting performance. In vitro and in vivo studies have reported various effects of PDE5i on cardiovascular, muscular, metabolic, and neuroendocrine systems and the potential, therefore, to enhance performance of healthy athletes during training and competition...
November 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/29135149/-arterial-priapism-as-a-complication-of-a-stab-wound-in-the-perianal-area
#12
S K Yarovoi, R A Khromov, V N Shipovskii
The article describes a case of successful managenent of arterial priapism in a patient with a stab wound in the perianal area. Timely performed angiography revealed a pathological connection between a. Uretralis sinistra and spongy body. Disruption of the abnormal shunt resulted in immediate relief of erection with further preservation of erectile function. At the 3 and 6 months follow-up visits there were no signs of cavernous fibrosis or erectile dysfunction. The authors analyze the entire sequence of events in the management of the case, identify shortcomings, determine their significance and consider their prevention...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29134487/sildenafil-citrate-use-in-addis-ababa-characteristics-of-users-and-pharmacists-dispensing-practices
#13
Dawit Teshome Gebregeorgise, Yajeb Melesse Belay, Sofia Kälvemark Sporrong
Background Studies have reported misuse of sildenafil citrate for recreational purpose, not least by healthy young men. This is becoming a major concern, for medical and other reasons. Objective The aim of this study was to document the characteristics of sildenafil citrate users and to explore the dispensing practices of the medicine in selected community pharmacies in Addis Ababa, Ethiopia. Setting Data was collected in community pharmacies in Addis Ababa, Ethiopia. Method A survey, using a self-administrated questionnaire, was conducted among customers who purchased sildenafil citrate from community pharmacies...
November 14, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29133962/chronic-periodontitis-and-the-risk-of-erectile-dysfunction-a-systematic-review-and-meta-analysis-methodological-issues
#14
Z Cheraghi, A Doosti-Irani
No abstract text is available yet for this article.
November 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29133940/stimulators-and-activators-of-soluble-guanylate-cyclase-for-urogenital-disorders
#15
REVIEW
Fabiola Z Mónica, Edson Antunes
Lower urinary tract symptoms (LUTS), comprising storage (such as urinary incontinence and urinary frequency), voiding, and postmicturition symptoms, are highly prevalent conditions that affect millions of people worldwide. LUTS have a profound effect on quality of life and are a considerable cost to health care systems. In men specifically, BPH commonly leads to LUTS. Clinical studies also show an association of LUTS with erectile dysfunction (ED). Nitric oxide (NO) has long been recognized as an important nonadrenergic, noncholinergic (NANC) transmitter in bladder, urethra, prostate, and corpus cavernosum smooth muscle...
November 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29131062/cardio-renal-determinants-of-erectile-dysfunction-in-primary-prevention-a-cross-sectional-study
#16
Vilma Dzenkeviciute, Zaneta Petrulioniene, Egidija Rinkuniene, Virginijus Sapoka, Marija Petrylaite, Jolita Badariene
OBJECTIVE: To investigate the association between severity of erectile dysfunction, cardiovascular risk and target organ (heart, renal, vascular) damage in men free of cardiovascular diseases (CV). SUBJECTS AND METHODS: This study included 182 men: 100 with erectile dysfunction (ED) (IIEF mean score ≤ 21) and 82 without ED (IIEF mean score > 21). The ED was assessed using the International Index of Erectile Function (IIEF-5). Ultrasound was used to evaluate carotid plaques and left ventricular mass, geometry and diastolic function...
November 5, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29128271/predictors-of-patient-and-partner-satisfaction-following-radical-prostatectomy
#17
REVIEW
Cailey Guercio, Akanksha Mehta
INTRODUCTION: The diagnosis and treatment of prostate cancer adversely affects the physical and emotional well-being of patients and partners and has been associated with sexual dysfunction in patients and their intimate partners. AIM: To identify predictors of sexual satisfaction in prostate cancer survivors and their partners based on a review of the current literature. METHODS: We performed a comprehensive review of the PubMed database from January 2000 to May 2017 focused on the (i) prevalence of patient and partner sexual dysfunction related to radical prostatectomy, (ii) differences in patient and partner perspectives of sexual function and dysfunction, and (iii) predictors of patient and partner sexual satisfaction after radical prostatectomy...
November 8, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29126846/sexual-function-and-quality-of-life-in-adult-male-individuals-with-exstrophy-epispadias-complex-a-survey-of-the-german-cure-network
#18
J Traceviciute, N Zwink, E Jenetzky, H Reutter, K Hirsch, R Stein, W H Rösch, A K Ebert
OBJECTIVE: To investigate sexual function and quality of life (QoL) in adult male individuals with exstrophy-epispadias complex (EEC). Data from the German network for congenital uro-rectal malformations (CURE-Net) were used. PATIENTS AND METHODS: 51 males (≥18 years) recruited by CURE-Net between 2009 and 2012 were re-contacted per mail and asked to fill out four questionnaires including International Index of Erectile Function (IIEF-5), Cologne assessment of Erectile Dysfunction (KEED), the Short-Form 36 (SF-36) and one self-designed questionnaire about their medical history, current health status, sexual experience...
November 7, 2017: Urology
https://www.readbyqxmd.com/read/29126844/prospective-outcome-analysis-of-the-safety-and-efficacy-of-partial-and-complete-cryoablation-in-organ-confined-prostate-cancer
#19
A Barqawi, E Huebner, K Krughoff, C I O'Donnell
OBJECTIVES: To determine the rate of complications and change in IPSS and SHIM scores following cryotherapy treatment of low and intermediate risk prostate cancer. Secondary endpoint was change in PSA post-cryotherapy and biopsy-proven recurrence. METHODS: Enrollment occurred from 2007-2015 to assess long-term complications of cryotherapy. A prostate biopsy was performed at one year or in the event of biochemical failure. Subjects were staged and graded by standard 12-14 core TRUS biopsy...
November 7, 2017: Urology
https://www.readbyqxmd.com/read/29122956/characterization-of-age-related-penile-microvascular-hemodynamic-impairment-using-laser-speckle-contrast-imaging-possible-role-of-increased-fibrogenesis
#20
Seung-Ryeol Lee, Ki-Ho Kim, Ho-Song You, Johnny Fu, Tung-Chin Mike Hsieh, Valmik Bhargava, M Raj Rajasekaran
Current technology for penile hemodynamic evaluations in small animals is invasive and has limitations. We evaluated a novel laser speckle contrast imaging (LSCI) technique to determine age-related changes in penile microvascular perfusion (PMP) and tested the role of cavernosal muscle (CC) fibrosis mediated by Wnt-TGF β1 signaling pathways in a mouse model. Ten young (2-3 months) and old (24-28 months) wild-type C57BL6 male mice were subjected to PMP measured using a LSCI system. Penile blood flow (PBF, peak systolic velocity, PSV) was also measured using a color Doppler ultrasound for comparison...
November 2017: Physiological Reports
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