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Fecal immunochemical testing

Yangming Gong, Peng Peng, Pingping Bao, Weijian Zhong, Yan Shi, Kai Gu, Ying Zheng, Chunxiao Wu, Sanjun Cai, Ye Xu, Jun Sheng, Fan Wu
BACKGROUND: The incidence and mortality rate of colorectal cancer (CRC) have increased dramatically over the past 3 decades in China due to changes in lifestyle factors. Early detection and treatment guidelines for asymptomatic cases have shown to improve CRC control in developed countries. In response to these challenges, the Shanghai Municipal Government launched a community-based CRC screening program in 2012. MATERIALS AND METHODS: Free initial screening, inclusive of immunochemical fecal occult blood and risk assessment (questionnaire), was provided by community health centers in Shanghai...
March 14, 2018: Oncologist
Simon J Craddock Lee, Stephen J Inrig, Bijal A Balasubramanian, Celette Sugg Skinner, Robin T Higashi, Katharine McCallister, Wendy Pechero Bishop, Noel O Santini, Jasmin A Tiro
The colorectal cancer (CRC) screening process involves multiple interfaces (communication exchanges and transfers of responsibility for specific actions) among primary care and gastroenterology providers, laboratory, and administrative staff. After a retrospective electronic health record (EHR) analysis discovered substantial clinic variation and low CRC screening prevalence overall in an urban, integrated safety-net system, we launched a qualitative analysis to identify potential quality improvement targets to enhance fecal immunochemical test (FIT) completion, the system's preferred screening modality...
March 2018: Preventive Medicine Reports
Chan Hyuk Park, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Yoon Suk Jung
BACKGROUND AND AIMS: Individuals without a family history of colorectal cancer (CRC) are screened uniformly despite interpersonal risk. To assess individual risk, we examined the age-specific prevalence of advanced colorectal neoplasia (ACRN) according to clinical risk factors and fecal immunochemical test (FIT) results. METHODS: Participants without a family history of CRC who underwent screening colonoscopy and FIT were included. Clinical risk factors for ACRN were identified using a logistic regression model...
March 3, 2018: Gastrointestinal Endoscopy
Jérôme Viguier, Jean-François Morère, Lysel Brignoli-Guibaudet, Christine Lhomel, Sébastien Couraud, François Eisinger
BACKGROUND: The aim of EDIFICE surveys is to improve insight into the behavior of the French population with regard to cancer prevention and participation in screening programs. Via the colorectal cancer screening program, all average-risk individuals in the 50-74-year age group are invited every 2 years to do a guaiac-based or, since April 2015, an immunochemical fecal occult blood test. METHODS: The fifth edition of the nationwide observational survey was conducted by phone interviews using the quota method...
March 5, 2018: Current Oncology Reports
Mark H Ebell, Thuy Nhu Thai, Kyle J Royalty
Background: Recommendations regarding cancer screening vary from country to country, and may also vary within countries depending on the organization making the recommendations. The goal of this study was to summarize the cancer screening recommendations from the 21 countries with the highest per capita spending on healthcare. Main body: Cancer screening guidelines were identified for each country based on a review of the medical literature, internet searches, and contact with key informants in most countries...
2018: Public Health Reviews
Amit G Singal, Douglas A Corley, Aruna Kamineni, Michael Garcia, Yingye Zheng, Paul V Doria-Rose, Virginia P Quinn, Christopher D Jensen, Jessica Chubak, Jasmin Tiro, Chyke A Doubeni, Nirupa R Ghai, Celette Sugg Skinner, Karen Wernli, Ethan A Halm
OBJECTIVES: Effectiveness of fecal occult blood test (FOBT) for colorectal cancer (CRC) screening depends on annual testing, but little is known about patterns of repeat stool-based screening within different settings. Our study's objective was to characterize screening patterns and identify factors associated with repeat screening among patients who completed an index guaiac FOBT (gFOBT) or fecal immunochemical test (FIT). METHODS: We performed a multi-center retrospective cohort study among people who completed a FOBT between January 2010 and December 2011 to characterize repeat screening patterns over the subsequent 3 years...
February 27, 2018: American Journal of Gastroenterology
Eugene Kligman, Wenfang Li, George J Eckert, Charles Kahi
BACKGROUND AND AIMS: The adenoma detection rate (ADR) is a powerful measure of screening colonoscopy quality. Patients who undergo colonoscopy for the evaluation of a positive fecal immunochemical test (FIT) have increased prevalence of colorectal neoplasia, but it is not known whether separate quality benchmarks are required. The aim of this study was to compare the conventional ADR to the ADR of colonoscopies performed for the evaluation of positive FIT, in asymptomatic average-risk patients...
February 22, 2018: Digestive Diseases and Sciences
Tobias Niedermaier, Korbinian Weigl, Michael Hoffmeister, Hermann Brenner
Background: Colorectal cancer (CRC) is a common but largely preventable cancer. Although fecal immunochemical tests (FITs) detect the majority of CRCs, they miss some of the cancers and most advanced adenomas (AAs). The potential of blood tests in complementing FITs for the detection of CRC or AA has not yet been systematically investigated. Methods: We conducted a systematic review of performance of FIT combined with an additional blood test for CRC and AA detection versus FIT alone...
February 2018: United European Gastroenterology Journal
Manon van der Vlugt, Esmée J Grobbee, Patrick M Bossuyt, Amanda C R K Bos, Ernst J Kuipers, Iris Lansdorp-Vogelaar, Manon C W Spaander, Evelien Dekker
BACKGROUND & AIMS: European guidelines recommend screening for colorectal cancer (CRC) using the fecal immunochemical test (FIT), with follow-up colonoscopies for individuals with positive test results. However, more than half of participants with positive results from the FIT are not found to have advanced neoplasia in the colonoscopy examination. Fecal occult blood might also come from the upper gastrointestinal (GI) tract, so perhaps we should consider esophagogastroduodenoscopy (EGD), to detect upper GI cancers...
February 7, 2018: Clinical Gastroenterology and Hepatology
Cong Dai, Min Jiang, Ming-Jun Sun, Qin Cao
OBJECTIVE: Fecal immunochemical test (FIT) is a promising marker for assessment of inflammatory bowel disease (IBD) activity. However, the utility of FIT for predicting mucosal healing (MH) of Ulcerative Colitis (UC) patients has yet to be clearly demonstrated. The objective of our study was to perform a diagnostic test accuracy test meta-analysis evaluating the diagnostic accuracy of FIT in predicting MH of UC patients. METHODS: We systematically searched the databases from inception to November 2017 that evaluated MH in UC...
February 10, 2018: Journal of Gastroenterology and Hepatology
Jasper L A Vleugels, Marcel G W Dijkgraaf, Yark Hazewinkel, Linda K Wanders, Paul Fockens, Evelien Dekker, M C J M Becx, A M van Berkel, W Bruins Slot, M Cazemier, A C T M Depla, J M J Geesing, T A Grool, G M P Houben, J M Jansen, K Kessels, M E van Leerdam, N van Lelyveld, R C Mallant-Hent, W A Marsman, E Schnekenburger, E J van Soest, B W van der Spek, P C F Stokkers, J Tenthof van Noorden, S A C van Tuyl, K M A J Tytgat, M T Uiterwaal, R C Verdonk, M A M T Verhagen, M van der Vlugt, A Voorburg, C A Wientjes
BACKGROUND & AIMS: Real-time differentiation of diminutive polyps (1-5 mm) during endoscopy could replace histopathology analysis. According to guidelines, implementation of optical diagnosis into routine practice would require it to identify rectosigmoid neoplastic lesions with a negative predictive value (NPV) of over 90%, using histologic findings as a reference, and agreement with histology-based surveillance intervals for more than 90% of cases. METHODS: We performed a prospective study with 39 endoscopists accredited to perform colonoscopies on participants with positive results from fecal immunochemical tests in the Bowel Cancer Screening Program at 13 centers in the Netherlands...
February 6, 2018: Gastroenterology
Jamie H Thompson, Melinda Davis, Michael C Leo, Jennifer L Schneider, David H Smith, Amanda F Petrik, Melissa Castillo, Brittany Younger, Gloria D Coronado
BACKGROUND: Colon cancer is the second leading cause of cancer deaths in the United States. The Participatory Research to Advance Colon Cancer Prevention (PROMPT) study is a collaboration between two research institutions and a federally qualified health center (FQHC). The study seeks to raise colon cancer screening rates using a direct-mail fecal immunochemical testing (FIT) and reminder program in an FQHC serving a predominantly Latino population in California. METHODS: PROMPT is a pragmatic trial enrolling 16 clinics...
February 2, 2018: Contemporary Clinical Trials
Jae Kwan Jun, Na Young Sung, Seung Hoon Song, Seri Hong, Mi Ae Jang, Junghan Song, Jeong Ho Kim, Won Ki Min, You Kyoung Lee
BACKGROUND: False-positive fecal immunochemical test (FIT) results in the National Cancer Screening Program (NCSP) for colorectal cancer may lead to unnecessary procedures, such as colonoscopies, increasing the medical costs. We estimated reductions in the cost of National Health Insurance according to the accreditation status of screening facilities participating in the NCSP for colorectal cancer. METHODS: We used data collected between 2007 and 2010 from NCSP and the Korea Central Cancer Registry to identify patients with colorectal cancer...
May 2018: Annals of Laboratory Medicine
Roisin Bevan, Matthew D Rutter
Colorectal cancer (CRC) is the third most common cancer worldwide. It is amenable to screening as it occurs in premalignant, latent, early, and curable stages. PubMed, Cochrane Database of Systematic Reviews, and national and international CRC screening guidelines were searched for CRC screening methods, populations, and timing. CRC screening can use direct or indirect tests, delivered opportunistically or via organized programs. Most CRCs are diagnosed after 60 years of age; most screening programs apply to individuals 50-75 years of age...
January 2018: Clinical Endoscopy
Putthikrai Pramual, Pongdech Sarakarn, Siriporn Kamsa-ard, Chananya Jirapornkul, Naowarat Maneenin, Prasert Thavondunstid, Prachak Juntarach, Supannee Promthet
Background: There is convincing evidence from epidemiological studies that meat consumption increases colorectal cancer (CRC) risk. However, assessment of any association with a positive fecal immunochemical test (FIT) in CRC screening has been limited. If a link could be shown this might be helpful for establishing a risk group for colonoscopy. Objective: This study aimed to assess any association between meat consumption and other lifestyle factors and a positive FIT result in a Thai population. Methods: A cross-sectional analytical study was conducted with 1,167 participants in a population-based randomized controlled trial...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Florence Bénard, Alan N Barkun, Myriam Martel, Daniel von Renteln
AIM: To summarize and compare worldwide colorectal cancer (CRC) screening recommendations in order to identify similarities and disparities. METHODS: A systematic literature search was performed using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge identifying all average-risk CRC screening guideline publications within the last ten years and/or position statements published in the last 2 years. In addition, a hand-search of the webpages of National Gastroenterology Society websites, the National Guideline Clearinghouse, the BMJ Clinical Evidence website, Google and Google Scholar was performed...
January 7, 2018: World Journal of Gastroenterology: WJG
Maria Teresa Rodia, Rossella Solmi, Francesco Pasini, Elena Nardi, Gabriella Mattei, Giampaolo Ugolini, Luigi Ricciardiello, Pierluigi Strippoli, Rossella Miglio, Mattia Lauriola
BACKGROUND: A noninvasive blood test for the early detection of colorectal cancer (CRC) is highly required. We evaluated a panel of 4 mRNAs as putative markers of CRC. MATERIALS AND METHODS: We tested LGALS4, CEACAM6, TSPAN8, and COL1A2, referred to as the CELTiC panel, using quantitative reverse transcription polymerase chain reaction, on subjects with positive fecal immunochemical test (FIT) results and undergoing colonoscopy. Using a nonparametric test and multinomial logistic model, FIT-positive subjects were compared with CRC patients and healthy individuals...
December 12, 2017: Clinical Colorectal Cancer
Marsha Woodall, Mary DeLetter
BACKGROUND: Colorectal cancer (CRC) is the third most commonly diagnosed cancer and second leading cause of cancer death for men and women in the United States. Although early detection and diagnosis greatly affect survival rates, only about half of the U.S. population participates in screening.
. OBJECTIVES: The purpose of this project was to implement community-based CRC education and screening. Outcomes included CRC knowledge, CRC screening kit return rate, and rate of positive screening results...
February 1, 2018: Clinical Journal of Oncology Nursing
Yoon Suk Jung, Chan Hyuk Park, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
OBJECTIVES: The fecal immunochemical test (FIT) has low sensitivity for detecting advanced colorectal neoplasia (ACRN); thus, a considerable portion of FIT-negative persons may have ACRN. We aimed to develop a risk-scoring model for predicting ACRN in FIT-negative persons. MATERIALS AND METHODS: We reviewed the records of participants aged ≥40 years who underwent a colonoscopy and FIT during a health check-up. We developed a risk-scoring model for predicting ACRN in FIT-negative persons...
2018: PloS One
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