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Fecal immunochemical testing

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https://www.readbyqxmd.com/read/29133254/characteristics-and-progression-of-preclinical-inflammatory-bowel-disease
#1
Iago Rodríguez-Lago, Olga Merino, Irene Azagra, Ainara Maiz, Eva Zapata, Rebeca Higuera, Isabel Montalvo, María Fernández-Calderón, Paz Arreba, Juan Carrascosa, Ainara Iriarte, Isabel Portillo, Urko Aguirre, Manuel Barreiro-de Acosta, Miguel Muñoz-Navas, José Luis Cabriada
BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is a chronic disease usually diagnosed after the appearance of gastrointestinal symptoms. Little is known about IBD progression during its early and even preclinical phases. We aimed to determine the number of new incidental diagnoses of IBD in an older population, and evaluate disease progression from its early stages. METHODS: We performed a retrospective analysis of 31,005 colonoscopies performed during colorectal cancer screening of patients with positive results from fecal immunochemical tests, at 11 centers in the Basque Country (Spain) from 2009 through 2014...
November 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29111981/the-detection-of-interval-colorectal-cancers-following-screening-by-fecal-immunochemical-test-may-predict-worse-outcomes-and-prompt-ethical-concerns-a-6-year-population-based-cohort-study-in-a-full-district
#2
Corrado R Asteria, Giuseppe Lucchini, Linda Guarda, Paolo Ricci, Mauro Pagani, Luigi Boccia
The rates of colorectal cancer (CRC) interval surveyed in screen-detected patients using a fecal immunochemical test (FIT) are not negligible. The aim of this study was to assess the effect of interval cancer on outcomes compared with a population with cancer diagnosed after a positive test result. All patients between 50 and 71 years of age, who were residents of the Mantua district, affected by CRC and operated on from 2005 to 2010 were reviewed. Other than patient-related, disease-related, and treatment-related factors and tumor location, this population was differentiated as either participating or not to screening and then into populations developing interval cancer after a negative FIT result...
November 3, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29109496/no-results-no-problem-why-we-are-publishing-methods-of-a-landmark-study-with-results-still-pending
#3
Brian E Lacy, Brennan Spiegel
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in both men and women in the United States, and screening for CRC is a national health-care priority. In this issue, investigators from the CONFIRM study group report on the aims and study design of a large, multicenter, randomized prospective study of whether screening colonoscopy is superior to an annual fecal immunochemical test (FIT). CONFRIM hopes to enroll 50,000 individuals, aged 50-75 years, from 46 Veterans Affairs Medical Centers and monitor them for 10 years...
November 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29102616/cost-effectiveness-of-screening-individuals-with-cystic-fibrosis-for-colorectal-cancer
#4
Andrea Gini, Ann G Zauber, Dayna R Cenin, Amir-Houshang Omidvari, Sarah E Hempstead, Aliza K Fink, Albert B Lowenfels, Iris Lansdorp-Vogelaar
BACKGROUND & AIMS: Individuals with cystic fibrosis are at increased risk of colorectal cancer (CRC) compared to the general population, and risk is higher among those who received an organ transplant. We performed a cost-effectiveness analysis to determine optimal CRC screening strategies for patients with cystic fibrosis. METHODS: We adjusted the existing MISCAN-Colon microsimulation model to reflect increased CRC risk and lower life-expectancy in patients with cystic fibrosis...
November 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29095416/rolling-out-screening-volume-affecting-compliance-rate-and-waiting-time-of-fit-based-colonoscopy
#5
Hsiao-Hsuan Jen, Chen-Yang Hsu, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Yi-Chia Lee, Ming-Shiang Wu, Wen-Feng Hsu, Szu-Min Peng, Hsiu-Hsi Chen, Han-Mo Chiu
BACKGROUND AND STUDY AIMS: The population-based colorectal cancer screening program with fecal immunochemical test (FIT) from the inaugural period to the rolling-out period may create a higher demand for colonoscopies, but such a change has not been quantified. We intended to assess the change in the compliance rate and the waiting time (WT) for a colonoscopy and the associated geographic and institutional variations across the 2 periods. MATERIALS AND METHODS: Data from the Taiwanese nationwide colorectal cancer screening program were analyzed...
October 31, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29072830/preliminary-results-colorectal-cancer-screening-using-fecal-immunochemical-test-fit-in-a-thai-population-aged-45-74-years-a-population-based-randomized-controlled-trial
#6
Pongdech Sarakarn, Supannee Promthet, Patravoot Vatanasapt, Nakhon Tipsunthonsak, Kriangsak Jenwitheesuk, Naowarat Maneenin, Chananya Jirapornkul, Siriporn Kamsa-ard, Tiptiya Haengsorn, Channarong Arkkhaboot, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Tony Hsiu-Hsi Chen
Objective: The aim of this paper is to provide some details and the results to date of a colorectal cancer screening trial using a fecal immunochemical test (FIT). Methods: A population-based randomized controlled trial began in May, 2016. All people aged 45 to 74 years living in Nam Phong District, Khon Kaen Province, Thailand, and willing to participate are being recruited using an outreach method. Enrolled participants are randomly allocated by a computer-generated randomization program either to a study arm (receive sample kit for FIT) or to a control arm (no provision of kit)...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29071819/is-it-necessary-to-repeat-fecal-occult-blood-tests-with-borderline-results-for-colorectal-cancer-screening
#7
Eunyoung Lee, Yangsoon Lee
The fecal immunochemical test (FIT) is the initial non-invasive investigation of choice for population-based colorectal cancer (CRC) screening. We evaluated the positivity rate in repeated tests using the same fecal specimen that showed borderline results in the FIT. A total of 6,465 patients were tested with the FIT in a tertiary-care hospital from July to December 2016. FIT was done using OC-Sensor PLEDIA (Eiken Chemical Co., Tokyo, Japan). Among 6,465 patients, 364 (5.6%) patients showed a positive FIT result of over 20 μg Hb/g feces...
January 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29049756/interventions-to-improve-follow-up-of-positive-results-on-fecal-blood-tests-a-systematic-review
#8
REVIEW
Kevin Selby, Christine Baumgartner, Theodore R Levin, Chyke A Doubeni, Ann G Zauber, Joanne Schottinger, Christopher D Jensen, Jeffrey K Lee, Douglas A Corley
Background: Fecal immunochemical testing is the most commonly used method for colorectal cancer screening worldwide. However, its effectiveness is frequently undermined by failure to obtain follow-up colonoscopy after positive test results. Purpose: To evaluate interventions to improve rates of follow-up colonoscopy for adults after a positive result on a fecal test (guaiac or immunochemical). Data Sources: English-language studies from the Cochrane Central Register of Controlled Trials, PubMed, and Embase from database inception through June 2017...
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29033369/fecal-clostridium-symbiosum-for-noninvasive-detection-of-early-and-advanced-colorectal-cancer-test-and-validation-studies
#9
Yuan-Hong Xie, Qin-Yan Gao, Guo-Xiang Cai, Xiao-Ming Sun, Tian-Hui Zou, Hui-Min Chen, Si-Yi Yu, Yi-Wen Qiu, Wei-Qi Gu, Xiao-Yu Chen, Yun Cui, Danfeng Sun, Zhan-Ju Liu, San-Jun Cai, Jie Xu, Ying-Xuan Chen, Jing-Yuan Fang
OBJECTIVE: Current non-invasive early detection of colorectal cancer (CRC) requires improvement. We aimed to identified a fecal Clostridium symbiosum-based biomarker for early and advanced colorectal cancer detection. DESIGN: In the test stage, the relative abundance of Clostridium symbiosum (C. symbiosum) was measured by qPCR in 781 cases including 242 controls, 212 colorectal adenoma (CRA) patients, 109 early CRC (tumor restricted to the submucosa) patients, 218 advanced CRC patients...
October 4, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29020876/screening-for-colorectal-cancer-at-the-worksite
#10
Louise C O'Keefe, Margaret M Sullivan, Amber McPhail, Kristen Van Buren, Nathan Dewberry
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths among men and women in the United States. To increase statewide CRC screening rates, the Alabama Department of Public Health (through a Centers for Disease Control and Prevention [CDC] Colorectal Cancer Control Program grant) partnered with The University of Alabama in Huntsville (UAH) and The University of South Alabama (USA) to provide free CRC screening opportunities to eligible University employees and dependents. Resources were invested at both universities to ensure participant education, tracking, and monitoring...
October 1, 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/29019046/effect-of-reminding-patients-to-complete-fecal-immunochemical-testing-a-comparative-effectiveness-study-of-automated-and-live-approaches
#11
Gloria D Coronado, Jennifer S Rivelli, Morgan J Fuoco, William M Vollmer, Amanda F Petrik, Erin Keast, Sara Barker, Emily Topalanchik, Ricardo Jimenez
BACKGROUND: The Community Preventive Services Task Force recommends multi-component interventions, including patient reminders, to improve uptake of colorectal cancer screening. OBJECTIVE: We sought to compare the effectiveness of different forms of reminders for a direct-mail fecal immunochemical test (FIT) program. DESIGN: Patient-randomized controlled trial. PARTICIPANTS: 2772 adults aged 50-75, not up to date with colorectal cancer screening recommendations, with a clinic visit in the previous year at any of four participating health center clinics...
October 10, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29016565/colonoscopy-vs-fecal-immunochemical-test-in-reducing-mortality-from-colorectal-cancer-confirm-rationale-for-study-design
#12
Jason A Dominitz, Douglas J Robertson, Dennis J Ahnen, James E Allison, Margaret Antonelli, Kathy D Boardman, Maria Ciarleglio, Barbara J Del Curto, Grant D Huang, Thomas F Imperiale, Meaghan F Larson, David Lieberman, Theresa O'Connor, Timothy J O'Leary, Peter Peduzzi, Dawn Provenzale, Aasma Shaukat, Shahnaz Sultan, Amy Voorhees, Robert Wallace, Peter D Guarino
RATIONALE: Colorectal cancer (CRC) is preventable through screening, with colonoscopy and fecal occult blood testing comprising the two most commonly used screening tests. Given the differences in complexity, risk, and cost, it is important to understand these tests' comparative effectiveness. STUDY DESIGN: The CONFIRM Study is a large, pragmatic, multicenter, randomized, parallel group trial to compare screening with colonoscopy vs. the annual fecal immunochemical test (FIT) in 50,000 average risk individuals...
November 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29016558/a-comparison-of-fecal-immunochemical-and-high-sensitivity-guaiac-tests-for-colorectal-cancer-screening
#13
Jean A Shapiro, Janet K Bobo, Timothy R Church, Douglas K Rex, Gary Chovnick, Trevor D Thompson, Ann G Zauber, David Lieberman, Theodore R Levin, Djenaba A Joseph, Marion R Nadel
OBJECTIVES: Annual testing using either a high-sensitivity guaiac fecal occult blood test (HS-gFOBT) or a fecal immunochemical test (FIT) is recommended for screening average-risk people for colorectal cancer. We compared the performance characteristics of the HS-gFOBT Hemoccult II SENSA and two FITs (InSure FIT and OC FIT-CHEK) for detecting advanced colorectal neoplasia. METHODS: The study included 1,006 asymptomatic patients, aged 50-75 years, who were scheduled to receive a screening colonoscopy at gastroenterology practices in the Minneapolis and Indianapolis metropolitan areas...
November 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28988890/current-status-and-future-challenge-of-population-based-organized-colorectal-cancer-screening-lesson-from-the-first-decade-of-taiwanese-program
#14
REVIEW
Ying-Wei Wang, Hsiu-Hsi Chen, Ming-Shiang Wu, Han-Mo Chiu
Colorectal cancer (CRC) is the most common cancer in Taiwan, and is the third leading cause of cancer-related death. Screening has been proven the most effective way to reduce CRC mortality, and stool-based screening is currently the most popular method of screening worldwide. In 2004, Taiwanese government launched a nationwide screening program and fecal immunochemical test (FIT) is offered biennially to individuals aged 50 to 75. The results from the program have demonstrated that FIT screening could effectively reduce the mortality from CRC...
October 5, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28973514/screening-for-colorectal-cancer-with-fecal-immunochemical-testing-with-and-without-postpolypectomy-surveillance-colonoscopy-a-cost-effectiveness-analysis
#15
Marjolein J E Greuter, Clasine M de Klerk, Gerrit A Meijer, Evelien Dekker, Veerle M H Coupé
Background: Population-based screening to prevent colorectal cancer (CRC) death is effective, but the effectiveness of postpolypectomy surveillance is unclear. Objective: To evaluate the additional benefit in terms of cost-effectiveness of colonoscopy surveillance in a screening setting. Design: Microsimulation using the ASCCA (Adenoma and Serrated pathway to Colorectal CAncer) model. Data Sources: Dutch CRC screening program and published literature...
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28967803/effect-of-temperature-and-time-on-fecal-hemoglobin-stability-in-5-fecal-immunochemical-test-methods-and-one-guaiac-method
#16
Peter Catomeris, Nancy N Baxter, Sheila C Boss, Lawrence F Paszat, Linda Rabeneck, Edward Randell, Mardie L Serenity, Rinku Sutradhar, Jill Tinmouth
CONTEXT: - Although promising for colorectal cancer screening, hemoglobin (Hb) stability remains a concern with fecal immunochemical tests. This study implemented a novel, standardized method to compare Hb stability across various fecal immunochemical tests. The method can be used to inform decisions when selecting a kit for use in colorectal cancer screening. In so doing, this work addressed a critical need for standardization in this field. OBJECTIVE: - To compare the stability of Hb across 5 different immunochemical kits and one guaiac kit...
October 2, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28961792/simultaneous-measurements-of-fecal-calprotectin-and-the-fecal-immunochemical-test-in-quiescent-ulcerative-colitis-patients-can-stratify-risk-of-relapse
#17
Asuka Nakarai, Sakiko Hiraoka, Sakuma Takahashi, Tomoki Inaba, Reiji Higashi, Motowo Mizuno, Shiho Takashima, Toshihiro Inokuchi, Yuusaku Sugihara, Masahiro Takahara, Keita Harada, Jun Kato, Hiroyuki Okada
Background: Both fecal calprotectin (Fcal) and the fecal immunochemical test (FIT) are useful to predict clinical relapse of ulcerative colitis (UC). However, the difference between Fcal and FIT in the ability to predict relapse has scarcely been reported. Whether the combined use of these two fecal markers increases the predictability is also unknown. Methods: UC patients in clinical remission who underwent colonoscopy were enrolled prospectively, and the Fcal and FIT values were examined at enrollment...
August 31, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28958859/direct-comparison-of-diagnostic-performance-of-9-quantitative-fecal-immunochemical-tests-for-colorectal-cancer-screening
#18
Anton Gies, Katarina Cuk, Petra Schrotz-King, Hermann Brenner
BACKGROUND & AIMS: A variety of fecal immunochemical tests (FITs) for hemoglobin (Hb) are used in colorectal cancer (CRC) screening. It is unclear to what extent differences in reported sensitivities and specificities reflect true heterogeneity in test performance or differences in study populations or varying pre-analytical conditions. We directly compared the sensitivity and specificity values with which 9 quantitative (laboratory-based and point of care) FITs detected advanced neoplasms (AN) in a single CRC screening study...
September 25, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28938500/acceptability-of-two-colorectal-cancer-screening-tests-pain-as-a-key-determinant-in-sigmoidoscopy
#19
Benedicte Kirkøen, Paula Berstad, Edoardo Botteri, Eirin Dalén, Jens Aksel Nilsen, Geir Hoff, Thomas de Lange, Tomm Bernklev
Background Participants' experience with a screening test can influence adherence, and therefore the efficacy of screening programs. We compared screening with unsedated flexible sigmoidoscopy and fecal immunochemical testing (FIT) for participants' satisfaction with the decision and for willingness to repeat colorectal cancer screening. Methods In a prospective, randomized trial 3257 individuals (50 - 74 years) were invited to either flexible sigmoidoscopy or FIT (1:1), of whom 1650 took up the offer (52...
November 2017: Endoscopy
https://www.readbyqxmd.com/read/28923816/-finding-the-right-fit-rural-patient-preferences-for-fecal-immunochemical-test-fit-characteristics
#20
Robyn Pham, Suzanne Cross, Bianca Fernandez, Kathryn Corson, Kristen Dillon, Coco Yackley, Melinda M Davis
PURPOSE: Colorectal cancer (CRC) is the third leading cause of cancer death in the United States, yet 1 in 3 Americans have never been screened for CRC. Annual screening using fecal immunochemical tests (FITs) is often a preferred modality in populations experiencing CRC screening disparities. Although multiple studies evaluate the clinical effectiveness of FITs, few studies assess patient preferences toward kit characteristics. We conducted this community-led study to assess patient preferences for FIT characteristics and to use study findings in concert with clinical effectiveness data to inform regional FIT selection...
September 2017: Journal of the American Board of Family Medicine: JABFM
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