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Fecal immunochemical testing

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https://www.readbyqxmd.com/read/28507758/fecal-immunochemical-test-based-colorectal-cancer-screening-the-gender-dilemma
#1
Esmée J Grobbee, Els Wieten, Bettina E Hansen, Esther M Stoop, Thomas R de Wijkerslooth, Iris Lansdorp-Vogelaar, Patrick M Bossuyt, Evelien Dekker, Ernst J Kuipers, Manon Cw Spaander
BACKGROUND: Despite differences between men and women in incidence of colorectal cancer (CRC) and its precursors, screening programs consistently use the same strategy for both genders. OBJECTIVE: The objective of this article is to illustrate the effects of gender-tailored screening, including the effects on miss rates of advanced neoplasia (AN). METHODS: Participants (age 50-75 years) in a colonoscopy screening program were asked to complete a fecal immunochemical test (FIT) before colonoscopy...
April 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28493543/contribution-of-patient-physician-and-environmental-factors-to-demographic-and-health-variation-in-colonoscopy-follow-up-for-abnormal-colorectal-cancer-screening-test-results
#2
Melissa R Partin, Amy A Gravely, James F Burgess, David A Haggstrom, Sarah E Lillie, David B Nelson, Sean M Nugent, Aasma Shaukat, Shahnaz Sultan, Louise C Walter, Diana J Burgess
BACKGROUND: Patient, physician, and environmental factors were identified, and the authors examined the contribution of these factors to demographic and health variation in colonoscopy follow-up after a positive fecal occult blood test/fecal immunochemical test (FOBT/FIT) screening. METHODS: In total, 76,243 FOBT/FIT-positive patients were identified from 120 Veterans Health Administration (VHA) facilities between August 16, 2009 and March 20, 2011 and were followed for 6 months...
May 11, 2017: Cancer
https://www.readbyqxmd.com/read/28483499/interval-colorectal-cancer-incidence-among-subjects-undergoing-multiple-rounds-of-fecal-immunochemical-testing
#3
Manon van der Vlugt, Esmée J Grobbee, Patrick M M Bossuyt, Amanda Bos, Evelien Bongers, Wolfert Spijker, Ernst J Kuipers, Iris Lansdorp-Vogelaar, Manon C W Spaander, Evelien Dekker
BACKGROUND & AIMS: Among subjects screened for colorectal cancer (CRC) by the guaiac fecal occult blood test, interval cancers develop in 48%-55% of the subjects. Data are limited on how many persons screened by fecal immunochemical tests (FIT), over multiple rounds, develop interval cancers. In the Netherlands, a pilot FIT-based biennial CRC screening program was conducted between 2006 and 2014. We collected and analyzed data from the program on CRCs detected during screening (SD-CRC) and CRCs not detected within the screening program (non-SD-CRC; such as FIT interval cancers, colonoscopy interval cancers and cancer in non-participants)...
May 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28475117/a-label-free-quantitative-fecal-hemoglobin-detection-platform-for-colorectal-cancer-screening
#4
Gita V Soraya, Thanh C Nguyen, Chathurika D Abeyrathne, Duc H Huynh, Jianxiong Chan, Phuong D Nguyen, Babak Nasr, Gursharan Chana, Patrick Kwan, Efstratios Skafidas
The early detection of colorectal cancer is vital for disease management and patient survival. Fecal hemoglobin detection is a widely-adopted method for screening and early diagnosis. Fecal Immunochemical Test (FIT) is favored over the older generation chemical based Fecal Occult Blood Test (FOBT) as it does not require dietary or drug restrictions, and is specific to human blood from the lower digestive tract. To date, no quantitative FIT platforms are available for use in the point-of-care setting. Here, we report proof of principle data of a novel low cost quantitative fecal immunochemical-based biosensor platform that may be further developed into a point-of-care test in low-resource settings...
May 5, 2017: Biosensors
https://www.readbyqxmd.com/read/28449340/identifying-the-optimal-strategy-for-screening-of-advanced-colorectal-neoplasia
#5
Yoon Suk Jung, Chan Hyuk Park, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND AND AIM: To guide selection of optimal screening strategies for advanced colorectal neoplasia (ACRN), we evaluated the screening performances of sigmoidoscopy, fecal immunochemical test (FIT), and the Asia-Pacific Colorectal Screening (APCS) system, as well as combinations of these techniques. METHODS: We reviewed the records of participants who had undergone a colonoscopy and FIT as part of a comprehensive health-screening program. Results of sigmoidoscopy were estimated from lesions under colonoscopic examination...
May 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28447866/which-fecal-immunochemical-test-should-i-choose
#6
Jeanette M Daly, Yinghui Xu, Barcey T Levy
OBJECTIVES: To summarize the fecal immunochemical tests (FITs) available in the United States, the 2014 pathology proficiency testing (PT) program FIT results, and the literature related to the test characteristics of FITs available in the United States to detect advanced adenomatous polyps (AAP) and/or colorectal cancer (CRC). METHODS: Detailed review of the Food and Drug Administration's Clinical Laboratory Improvement Amendments (CLIA) database of fecal occult blood tests, the 2014 FIT PT program results, and the literature related to FIT accuracy...
April 1, 2017: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/28444278/association-between-time-to-colonoscopy-after-a-positive-fecal-test-result-and-risk-of-colorectal-cancer-and-cancer-stage-at-diagnosis
#7
Douglas A Corley, Christopher D Jensen, Virginia P Quinn, Chyke A Doubeni, Ann G Zauber, Jeffrey K Lee, Joanne E Schottinger, Amy R Marks, Wei K Zhao, Nirupa R Ghai, Alexander T Lee, Richard Contreras, Charles P Quesenberry, Bruce H Fireman, Theodore R Levin
Importance: The fecal immunochemical test (FIT) is commonly used for colorectal cancer screening and positive test results require follow-up colonoscopy. However, follow-up intervals vary, which may result in neoplastic progression. Objective: To evaluate time to colonoscopy after a positive FIT result and its association with risk of colorectal cancer and advanced-stage disease at diagnosis. Design, Setting, and Participants: Retrospective cohort study (January 1, 2010-December 31, 2014) within Kaiser Permanente Northern and Southern California...
April 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28427954/colorectal-cancer-screening-initiation-after-age-50-years-in-an-organized-program
#8
Stacey A Fedewa, Douglas A Corley, Christopher D Jensen, Wei Zhao, Michael Goodman, Ahmedin Jemal, Kevin C Ward, Theodore R Levin, Chyke A Doubeni
INTRODUCTION: Recent studies report racial disparities among individuals in organized colorectal cancer (CRC) programs; however, there is a paucity of information on CRC screening utilization by race/ethnicity among newly age-eligible adults in such programs. METHODS: This was a retrospective cohort study among Kaiser Permanente Northern California enrollees who turned age 50 years between 2007 and 2012 (N=138,799) and were served by a systemwide outreach and facilitated in-reach screening program based primarily on mailed fecal immunochemical tests to screening-eligible people...
April 17, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28402402/evaluation-of-the-effectiveness-and-cost-effectiveness-of-personalized-surveillance-after-colorectal-adenomatous-polypectomy
#9
Ethna McFerran, James F O'Mahony, Richard Fallis, Duncan McVicar, Ann G Zauber, Frank Kee
Lifetime risk of developing colorectal cancer is 5%, and 5-year survival at early stage is 92%. Individuals with precancerous lesions removed at primary screening are typically recommended surveillance colonoscopy. Because greater benefits are anticipated for those with higher risk of colorectal cancer, scope for risk-specific surveillance recommendations exists. This review assesses published cost-effectiveness estimates of postpolypectomy surveillance to consider the potential for personalized recommendations by risk group...
January 1, 2017: Epidemiologic Reviews
https://www.readbyqxmd.com/read/28398836/providing-quantitative-information-and-a-nudge-to-undergo-stool-testing-in-a-colorectal-cancer-screening-decision-aid
#10
Peter H Schwartz, Susan M Perkins, Karen K Schmidt, Paul F Muriello, Sandra Althouse, Susan M Rawl
BACKGROUND: Guidelines recommend that patient decision aids should provide quantitative information about probabilities of potential outcomes, but the impact of this information is unknown. Behavioral economics suggests that patients confused by quantitative information could benefit from a "nudge" towards one option. We conducted a pilot randomized trial to estimate the effect sizes of presenting quantitative information and a nudge. METHODS: Primary care patients (n = 213) eligible for colorectal cancer screening viewed basic screening information and were randomized to view (a) quantitative information (quantitative module), (b) a nudge towards stool testing with the fecal immunochemical test (FIT) (nudge module), (c) neither a nor b, or (d) both a and b...
March 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28385585/colorectal-cancer-screening-with-the-fecal-immunochemical-test-in-persons-aged-30-to-49-years-focusing-on-the-age-for-commencing-screening
#11
Yoon Suk Jung, Chan Hyuk Park, Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND AND AIMS: The fecal immunochemical test (FIT) can be an alternative screening method for colorectal cancer in individuals aged <50 years. However, debate continues concerning the age at which commencing FIT is beneficial. METHODS: We reviewed the records of participants who had undergone a colonoscopy and FIT as part of a comprehensive health screening program. To determine the age for commencing screening via FIT, participants aged <50 years were classified into 4 age subgroups as follows: 30 to 34, 35 to 39, 40 to 44, and 45 to 49 years...
April 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28376228/association-between-colorectal-cancer-mortality-and-gradient-fecal-hemoglobin-concentration-in-colonoscopy-noncompliers
#12
Yi-Chia Lee, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Shu-Lin Chuang, Tsung-Hsien Chiang, Chu-Kuang Chou, Han-Mo Chiu, Ming-Shiang Wu, Chien-Yuan Wu, Shu-Li Chia, Shu-Ti Chiou, Hsiu-Hsi Chen
Background: To what extent the risk for colorectal cancer (CRC) death among noncompliers of colonoscopy is elevated following positive fecal immunological testing and whether the elevated risk varies with the fecal hemoglobin concentration (f-Hb) and location of CRC have not been researched. Methods: We used data on 59 389 individuals (4.0%) among 1 489 937 Taiwanese screenees age 50 to 69 years with f-Hb 20 μg hemoglobin or more per gram of feces from 2004 to 2009...
May 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28345822/the-optimal-cut-off-level-of-the-fecal-immunochemical-test-for-colorectal-cancer-screening-in-a-country-with-limited-colonoscopy-resources-a-multi-center-study-from-thailand
#13
Satimai Aniwan, Thawee Ratanachu Ek, Supot Pongprasobchai, Julajak Limsrivilai, Ong Ard Praisontarangkul, Pises Pisespongsa, Pisaln Mairiang, Apichat Sangchan, Jaksin Sottisuporn, Naruemon Wisedopas, Pinit Kullavanijaya, Rungsun Rerknimitr
Background: Selecting the cut-off point for the fecal immunochemical test (FIT) for colorectal cancer (CRC) screening programs is of prime importance. The balance between the test performance for detecting advanced neoplasia and the available colonoscopy resources should be considered. We aimed to identify the optimal cut-off of FIT for advanced neoplasia in order to minimize colonoscopy burden. Methods: We conducted a multi-center study in 6 hospitals from diverse regions of Thailand. Asymptomatic participants, aged 50-75 years, were tested with one-time quantitative FIT (OC-SENSOR, Eiken Chemical Co...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28344793/correlation-between-adenoma-detection-rate-in-colonoscopy-and-fecal-immunochemical-testing-based-colorectal-cancer-screening-programs
#14
Joaquín Cubiella, Antoni Castells, Montserrat Andreu, Luis Bujanda, Fernando Carballo, Rodrigo Jover, Ángel Lanas, Juan Diego Morillas, Dolores Salas, Enrique Quintero
BACKGROUND: The adenoma detection rate (ADR) is the main quality indicator of colonoscopy. The ADR recommended in fecal immunochemical testing (FIT)-based colorectal cancer screening programs is unknown. METHODS: Using the COLONPREV (NCT00906997) study dataset, we performed a post-hoc analysis to determine if there was a correlation between the ADR in primary and work-up colonoscopy, and the equivalent figure to the minimal 20% ADR recommended. Colonoscopy was performed in 5722 individuals: 5059 as primary strategy and 663 after a positive FIT result (OC-Sensor™; cut-off level 15 µg/g of feces)...
March 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28296927/harms-benefits-and-costs-of-fecal-immunochemical-testing-versus-guaiac-fecal-occult-blood-testing-for-colorectal-cancer-screening
#15
S Lucas Goede, Linda Rabeneck, Marjolein van Ballegooijen, Ann G Zauber, Lawrence F Paszat, Jeffrey S Hoch, Jean H E Yong, Sonja Kroep, Jill Tinmouth, Iris Lansdorp-Vogelaar
BACKGROUND: The ColonCancerCheck screening program for colorectal cancer (CRC) in Ontario, Canada, is considering switching from biennial guaiac fecal occult blood test (gFOBT) screening between age 50-74 years to the more sensitive, but also less specific fecal immunochemical test (FIT). The aim of this study is to estimate whether the additional benefits of FIT screening compared to gFOBT outweigh the additional costs and harms. METHODS: We used microsimulation modeling to estimate quality adjusted life years (QALYs) gained and costs of gFOBT and FIT, compared to no screening, in a cohort of screening participants...
2017: PloS One
https://www.readbyqxmd.com/read/28295627/second-local-recurrence-with-advanced-rectal-cancer-after-salvage-emr-of-local-recurrence-following-initial-cold-polypectomy
#16
Motohiko Kato, Junichi Shiraishi, Toshio Uraoka
A 60-year-old woman underwent colonoscopy for a positive fecal immunochemical test. A 5 mm sessile polyp (Paris type 0-Isp) was found in the lower rectum (Figure 1a). This polyp was diagnosed as a low-grade adenoma based on findings of magnification colonoscopy with narrow band imaging (Figure 1b) and then was resected in a single piece with cold snare polypectomy. This article is protected by copyright. All rights reserved.
March 14, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28282604/the-fecal-occult-blood-test-as-a-tool-for-improved-outpatient-qualification-for-colonoscopy-a-single-center-experience-and-10-year-follow-up-survey
#17
Zbigniew Banaszkiewicz, Jacek Budzyński, Krzysztof Tojek, Paweł Jarmocik, Jacek Frasz, Marcin Mrozowski, Maciej Świtoński, Arkadiusz Jawień
PURPOSE: Colonoscopy is not widely and easily available in all countries, even for symptomatic patients. This is one of the causes of tumors not being diagnosed until an advanced stage. The aim of this study was to estimate the efficacy of the fecal occult blood test (FOBT) in the diagnostic work-up of outpatients referred to a colorectal unit due to indistinct abdominal symptoms. PATIENTS/METHODS: Among 10418 consecutive symptomatic individuals referred to the outpatient clinic, an immunochemical FOBT (Hem-Check 1(®)) was recommended for 9432 patients with indistinct symptoms as a tool for qualifying them for colonoscopy...
March 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28258145/comparison-of-fecal-collection-methods-for-microbiota-studies-in-bangladesh
#18
Emily Vogtmann, Jun Chen, Muhammad G Kibriya, Yu Chen, Tariqul Islam, Mahbubul Eunes, Alauddin Ahmed, Jabun Naher, Anisur Rahman, Amnon Amir, Jianxin Shi, Christian C Abnet, Heidi Nelson, Rob Knight, Nicholas Chia, Habibul Ahsan, Rashmi Sinha
To our knowledge, fecal microbiota collection methods have not been evaluated in low- and middle-income countries. Therefore, we evaluated five different fecal sample collection methods for technical reproducibility, stability, and accuracy within the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. Fifty participants from the HEALS provided fecal samples in the clinic which were aliquoted into no solution, 95% ethanol, RNAlater, postdevelopment fecal occult blood test (FOBT) cards, and fecal immunochemical test (FIT) tubes...
May 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28255255/validity-of-data-in-the-danish-colorectal-cancer-screening-database
#19
Mette Kielsholm Thomsen, Sisse Helle Njor, Morten Rasmussen, Dorte Linnemann, Berit Andersen, Gunnar Baatrup, Lennart Jan Friis-Hansen, Jens Christian Riis Jørgensen, Ellen Margrethe Mikkelsen
BACKGROUND: In Denmark, a nationwide screening program for colorectal cancer was implemented in March 2014. Along with this, a clinical database for program monitoring and research purposes was established. OBJECTIVE: The aim of this study was to estimate the agreement and validity of diagnosis and procedure codes in the Danish Colorectal Cancer Screening Database (DCCSD). METHODS: All individuals with a positive immunochemical fecal occult blood test (iFOBT) result who were invited to screening in the first 3 months since program initiation were identified...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28243039/fecal-occult-blood-testing-for-the-prediction-of-small-bowel-pathology-detected-by-capsule-endoscopy-a-systematic-review-and-meta-analysis
#20
Diana E Yung, Sanju Vijayan, Tomer Avni, Sarah Douglas, Uri Kopylov, Anastasios Koulaouzidis
BACKGROUND: Fecal occult blood testing (FOBT) has been suggested as a potential screening tool for small-bowel capsule endoscopy (CE). We conducted a meta-analysis of studies correlating FOBT and CE findings to examine the predictive value of positive FOBT for CE findings. METHODS: PubMed and Embase search. Sensitivity, specificity and diagnostic odds ratios (DORs) were calculated. RESULTS: Six studies were identified. Four used fecal immunochemical testing (FIT), one used FIT and guaiac FOBT, one used hemoglobin/haptoglobin complex testing (Hb/Hpt)...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
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