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H. pylori prophylaxis

Hendrik Ueberschaer, Hans-Dieter Allescher
Proton Pump Inhibitors are among the most common drugs taken. The indication is for treatment of heartburn, reflux disease, prophylaxis and treatment of peptic ulcers, in combination with NSAIDs and steroids as well as H. pylori-eradication. PPI's are widely used, even with non-specific symptoms. This certainly has to do with good tolerability and a previously considered low side effect profile. At the moment, there is growing evidence that the long-term intake of PPI's may not be as safe as assumed. In addition to interactions with some drugs, including platelet aggregation inhibitors, recent studies have shown an increased risk of myocardial infarction, interstitial nephritis, chronic renal injury, infections, vitamin deficiencies and electrolyte shifts as well developing dementia...
January 2017: Zeitschrift Für Gastroenterologie
Vincenzo Savarino, Pietro Dulbecco, Nicola de Bortoli, Andrea Ottonello, Edoardo Savarino
The advent of powerful acid-suppressive drugs, such as proton pump inhibitors (PPIs), has revolutionized the management of acid-related diseases and has minimized the role of surgery. The major and universally recognized indications for their use are represented by treatment of gastro-esophageal reflux disease, eradication of Helicobacter pylori infection in combination with antibiotics, therapy of H. pylori-negative peptic ulcers, healing and prophylaxis of non-steroidal anti-inflammatory drug-associated gastric ulcers and control of several acid hypersecretory conditions...
January 2017: European Journal of Internal Medicine
H M Steffen
The S2k-Guideline "Helicobacter pylori and gastroduodenal ulcer disease" offers a statement and comment on the subject of stress ulcer prophylaxis that need a critical response.
October 2016: Zeitschrift Für Gastroenterologie
Ian M Gralnek, Jean-Marc Dumonceau, Ernst J Kuipers, Angel Lanas, David S Sanders, Matthew Kurien, Gianluca Rotondano, Tomas Hucl, Mario Dinis-Ribeiro, Riccardo Marmo, Istvan Racz, Alberto Arezzo, Ralf-Thorsten Hoffmann, Gilles Lesur, Roberto de Franchis, Lars Aabakken, Andrew Veitch, Franco Radaelli, Paulo Salgueiro, Ricardo Cardoso, Luís Maia, Angelo Zullo, Livio Cipolletta, Cesare Hassan
This Guideline is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE). It addresses the diagnosis and management of nonvariceal upper gastrointestinal hemorrhage (NVUGIH). Main Recommendations MR1. ESGE recommends immediate assessment of hemodynamic status in patients who present with acute upper gastrointestinal hemorrhage (UGIH), with prompt intravascular volume replacement initially using crystalloid fluids if hemodynamic instability exists (strong recommendation, moderate quality evidence)...
October 2015: Endoscopy
Katayoun Borhani, Ashraf Mohabati Mobarez, Ali Reza Khabiri, Mehrdad Behmanesh, Nima Khoramabadi
PURPOSE: The common triple therapy for Helicobacter pylori is challenged by the increasing cases of antibiotic resistant infections, raising the need to explore alternative therapies. Oral administration of egg yolk immunoglobulin Y (IgY) has been previously reported as a means of passive immunization therapy for H. pylori infections. In this work, we investigated the inhibitory effect of IgY on the attachment of H. pylori to AGS cell line. MATERIALS AND METHODS: Recombinant OipA was prepared...
July 2015: Clinical and Experimental Vaccine Research
Iu A Rakhmanin, S V German
AIM OF THE STUDY: On the available reports to assess the possibility of the infection with pyloric Helicobacter (H.pylori) from external sources--via contaminated food and water. BASIC CONCEPTS: H. pylori was established to be unable to multiply in dairy and other products, but under favorable conditions, can survive in the limited time. There are obtained epidemiological data about the feedback between the prevalence of H. pylori infection in the region and the availability of safe water...
January 2015: Gigiena i Sanitariia
Yuji Aiba, Yasuhiro Nakano, Yasuhiro Koga, Kenji Takahashi, Yasuhiko Komatsu
A novel strain of Lactobacillus johnsonii No. 1088 was isolated from the gastric juice of a healthy Japanese male volunteer, and characterized for its effectiveness in the stomach environment. Lactobacillus johnsonii No. 1088 was found to have the strongest acid resistance among several lactobacilli examined (>10% of cells survived at pH 1.0 after 2 h), and such a high acid resistance property was a specific characteristic of this strain of L. johnsonii. When cultured with various virulent bacteria, L. johnsonii No...
June 2015: MicrobiologyOpen
John J Kelly, Richard A Perugini, Qi L Wang, Donald R Czerniach, Julie Flahive, Philip A Cohen
BACKGROUND: Eradication of Helicobacter pylori prior to Roux-en-Y gastric bypass (RYGB) has been advocated as a measure to reduce the complications of anastomotic ulceration. However, evidence to support a causal relationship between preoperative H. pylori status and postoperative anastomotic ulceration is weak. METHODS: Intraoperative gastric biopsies were obtained on consecutive patients who underwent laparoscopic RYGB at our institution from December 2007 to June 2010...
October 2015: Surgical Endoscopy
C R Preslaski, S W Mueller, T H Kiser, D N Fish, R MacLaren
WHAT IS KNOWN AND OBJECTIVE: Practices vary between institutions and amongst prescribers regarding when to initiate stress ulcer prophylaxis (SUP), which agent to choose (including doses and frequencies) and rationale, and decisions about escalation or discontinuation of therapy. The purpose of this survey is to evaluate the perceptions of prescribers about risk assessment of stress-related mucosal bleeding (SRMB) and practice patterns of SUP. METHODS: A cross-sectional survey of 800 US critical care prescribers using the membership of the Society of Critical Care Medicine...
December 2014: Journal of Clinical Pharmacy and Therapeutics
Pin-Yao Wang, Hsiu-Ping Chen, Angela Chen, Feng-Woei Tsay, Kwok-Hung Lai, Sung-Shuo Kao, Wen-Chi Chen, Chao-Hung Kuo, Nan-Jing Peng, Hui-Hwa Tseng, Ping-I Hsu
AIMS: To investigate the impact of blood type, functional polymorphism (T-1676C) of the COX-1 gene promoter, and clinical factors on the development of peptic ulcer during cardiovascular prophylaxis with low-dose aspirin. METHODS: In a case-control study including 111 low-dose aspirin users with peptic ulcers and 109 controls (asymptomatic aspirin users), the polymorphism (T-1676C) of the COX-1 gene promoter was genotyped, and blood type, H pylori status, and clinical factors were assessed...
2014: BioMed Research International
Yun Jeong Lim, Su Jin Hong
NSAID-induced upper gastrointestinal (GI) damage occurs easily in people with a prior history of complicated or uncomplicated ulcers. Many recent clinical studies have proved the benefit of Helicobacter pylori eradication in NSAID users; however, the exact pathophysiologic relationship between concomitant H. pylori infection and NSAID use has not yet been fully elucidated. Testing and eradication of H. pylori are generally recommended in patients who are at a high risk for NSAID-induced GI damage. However, in high-risk patients, ulcer prophylaxis with proton pump inhibitor or misoprostol is needed even if H...
August 2014: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
J Cuzick, M A Thorat, C Bosetti, P H Brown, J Burn, N R Cook, L G Ford, E J Jacobs, J A Jankowski, C La Vecchia, M Law, F Meyskens, P M Rothwell, H J Senn, A Umar
BACKGROUND: Accumulating evidence supports an effect of aspirin in reducing overall cancer incidence and mortality in the general population. We reviewed current data and assessed the benefits and harms of prophylactic use of aspirin in the general population. METHODS: The effect of aspirin for site-specific cancer incidence and mortality, cardiovascular events was collated from the most recent systematic reviews. Studies identified through systematic Medline search provided data regarding harmful effects of aspirin and baseline rates of harms like gastrointestinal bleeding and peptic ulcer...
January 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Takahiro Uotani, Mitsushige Sugimoto, Masafumi Nishino, Hitomi Ichikawa, Shu Sahara, Mihoko Yamade, Moriya Iwaizumi, Takanori Yamada, Satoshi Osawa, Ken Sugimoto, Kazuo Umemura, Hiroshi Watanabe, Hiroaki Miyajima, Takahisa Furuta
Anti-platelet drug-induced gastric mucosal injury correlates with intragastric pH. Our aim was to investigate prophylaxis effects of famotidine, one of the representative histamine-2 receptor antagonists (H2RA), on gastric mucosal injury induced by dual therapy with low-dose aspirin and clopidogrel in relation to Helicobacter pylori (H. pylori) infection and CYP2C19 genotypes. This study was conducted for 20 healthy Japanese volunteers (10 H. pylori-positive and 10-negative subjects) with 100 mg aspirin plus 75 mg clopidogrel (AC) once-daily dosing and AC plus 20 mg famotidine twice-daily dosing (ACH)...
August 2014: Journal of Clinical Pharmacology
Y Lu, R Loffroy, J Y W Lau, A Barkun
BACKGROUND: The modern management of acute non-variceal upper gastrointestinal bleeding is centred on endoscopy, with recourse to interventional radiology and surgery in refractory cases. The appropriate use of intervention to optimize outcomes is reviewed. METHODS: A literature search was undertaken of PubMed and the Cochrane Central Register of Controlled Trials between January 1990 and April 2013 using validated search terms (with restrictions) relevant to upper gastrointestinal bleeding...
January 2014: British Journal of Surgery
Han-Yi Song, Yan Li
AIM: To evaluate the influence of oral Helicobacter pylori (H. pylori) on the success of eradication therapy against gastric H. pylori. METHODS: A total of 391 patients with dyspepsia were examined for H. pylori using the saliva H. pylori antigen test (HPS), ¹³C-urea breath test (UBT), gastroscopy, and gastric mucosal histopathological detection. Another 40 volunteers without discomfort were subjected to HPS and ¹³C-UBT, and served as the control group. The 233 patients who were (¹³C-UBT+ were enrolled in this study and divided into 4 groups...
October 21, 2013: World Journal of Gastroenterology: WJG
Chun-Ling Jia, Guang-Shui Jiang, Chun-Hai Li, Cui-Rong Li
BACKGROUND: Data on the role of dental plaque in the transmission of Helicobactor pylori have varied. Furthermore, there has been few reports on the relationship between dental plaque control and H. pylori infection of gastric mucosa. The purpose of this study was to elucidate this potential relationship. METHODS: The 13C urea breath test was conducted on 56 subjects who received dental plaque control and 51 subjects who did not. RESULTS: The prevalence of H...
October 2012: Texas Dental Journal
Akshay J Patel, Robin Som
A best evidence topic was written according to a structured protocol. The question addressed was what is the optimum prophylaxis against gastrointestinal haemorrhage for patients undergoing adult cardiac surgery: histamine receptor antagonists (H(2)RA) or proton-pump inhibitors? A total of 201 papers were found; of which, 8 represented the best evidence. The authors, date, journal, study type, population, main outcome measures and results were tabulated. Only one randomized controlled trial (RCT) with relevant clinical outcomes was identified...
March 2013: Interactive Cardiovascular and Thoracic Surgery
Mototsugu Kato, Masahiro Asaka
A mass screening program using photofluorography has been used as a secondary prophylaxis of gastric cancer in Japan. However, we are at a turning point for reconsidering the strategy of gastric cancer prevention because of various problems with photofluorography. The shift from current secondary prophylaxis to primary prophylaxis is now required. After a Japanese multicenter randomized controlled trial showed that Helicobacter pylori eradication reduced the incidence of metachronous gastric cancer after endoscopic resection of early gastric cancer, primary prophylaxis of gastric cancer has gained greater attention...
November 2012: Japanese Journal of Clinical Oncology
G N J Tytgat
Ulceration corresponds to tissue loss, breaching the muscularis mucosae. When ulcers develop in the acid-peptic environment of the gastroduodenum, they are traditionally called peptic ulcer (PUD). Ulcers never develop spontaneously in a healthy gastroduodenal mucosa. Ulceration is the ultimate consequence of a disequilibrium between aggressive injurious factors and defensive mucosa-protective factors. The dominant aggressors are strong acid and high proteolytic (pepsin) activity in gastric secretions. The dominant defensors are the phospholipid surfactant layer, covering the mucus bicarbonate gel, the mucus bicarbonate layer covering the epithelium, the tight junctional structures between the epithelial cells, restricting proton permeability, and the epithelial trefoil peptides, contributing to healing after injury...
2011: Digestive Diseases
Yi-Chia Lee, Jyh-Ming Liou, Ming-Shiang Wu, Chun-Ying Wu, Jaw-Town Lin
Helicobacter pylori (H. pylori) are gram-negative bacteria that selectively colonizes the gastric mucosa. The prevalence of H. pylori infection varies from 20 to 50% in industrialized countries to over 80% in developing countries. The infection may persist lifelong without specific treatment. Prolonged infection and inflammation due to bacterial virulence and host genetic factors will lead to chronic gastritis. A certain portion of infected patients then develop more severe pathologies such as peptic ulcer (10-15%), gastric cancer (1%), and mucosa-associated lymphoid tissue lymphoma (50...
September 2008: Therapeutic Advances in Gastroenterology
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