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https://www.readbyqxmd.com/read/28095911/mistreatment-of-women-during-childbirth-in-abuja-nigeria-a-qualitative-study-on-perceptions-and-experiences-of-women-and-healthcare-providers
#1
Meghan A Bohren, Joshua P Vogel, Özge Tunçalp, Bukola Fawole, Musibau A Titiloye, Akinpelu Olanrewaju Olutayo, Modupe Ogunlade, Agnes A Oyeniran, Olubunmi R Osunsan, Loveth Metiboba, Hadiza A Idris, Francis E Alu, Olufemi T Oladapo, A Metin Gülmezoglu, Michelle J Hindin
BACKGROUND: Global efforts have increased facility-based childbirth, but substantial barriers remain in some settings. In Nigeria, women report that poor provider attitudes influence their use of maternal health services. Evidence also suggests that women in Nigeria may experience mistreatment during childbirth; however, there is limited understanding of how and why mistreatment this occurs. This study uses qualitative methods to explore women and providers' experiences and perceptions of mistreatment during childbirth in two health facilities and catchment areas in Abuja, Nigeria...
January 17, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28089755/biodistribution-and-retention-of-locally-administered-human-mesenchymal-stromal-cells-quantitative-polymerase-chain-reaction-based-detection-of-human-dna-in-murine-organs
#2
Michael Creane, Linda Howard, Timothy O'Brien, Cynthia M Coleman
BACKGROUND: Determining the distributive fate and retention of a cell therapy product after administration is an essential part of characterizing it's biosafety profile. Therefore, regulatory guidelines stipulate that biodistribution assays are a requirement prior to advancing a cell therapy to the clinic. Here the development of a highly sensitive quantitative polymerase chain reaction (qPCR)-based method of tracking the biodistribution and retention of human mesenchymal stromal cells (hMSCs) in mice, rats or rabbits is described...
January 12, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28068183/nucleolar-aggresomes-mediate-release-of-pericentric-heterochromatin-and-nuclear-destruction-of-genotoxically-treated-cancer-cells
#3
Kristine Salmina, Anda Huna, Inna Inashkina, Alexander Belyayev, Jekabs Krigerts, Ladislava Pastova, Alejandro Vazquez-Martin, Jekaterina Erenpreisa
The role of the nucleolus and autophagy in maintenance of nuclear integrity is poorly understood. In addition, the mechanisms of nuclear destruction in cancer cells senesced after conventional chemotherapy are unclear. In an attempt to elucidate these issues, we studied teratocarcinoma PA1 cells treated with Etoposide (ETO), focussing on the nucleolus. Following treatment, most cells enter G2 arrest, display persistent DNA damage and activate p53, senescence, and macroautophagy markers. 2-5 µm sized nucleolar aggresomes (NoA) containing fibrillarin (FIB) and damaged rDNA, colocalised with ubiquitin, pAMPK, and LC3-II emerge, accompanied by heterochromatin fragments, when translocated perinuclearly...
January 9, 2017: Nucleus
https://www.readbyqxmd.com/read/28063323/genetic-and-epigenetic-regulation-on-the-transcription-of-gabrb2-genotype-dependent-hydroxymethylation-and-methylation-alterations-in-schizophrenia
#4
Lu Zong, Lin Zhou, Yu Hou, Lulu Zhang, Wei Jiang, Wenwei Zhang, Lijuan Wang, Xia Luo, Shiqing Wang, Cong Deng, Zhizhen Peng, Shufen Li, Jiming Hu, Hu Zhao, Cunyou Zhao
To improve our understanding of the abnormalities and non-Mendelian inheritance characteristics of schizophrenia, this study examined DNA methylation (5mC) and hydroxymethylation (5hmC) in the schizophrenia-associated GABRB2 gene encoding the type A γ-aminobutyric acid receptor β2 subunit. DNAs from the peripheral white blood cells of 279 schizophrenic patients and 256 controls from the Chinese Han population were examined to reveal that the GABRB2 promoter P1-5mC level which was correlated with olanzapine administration, P2-5mC/5hmC level, and Alu-5mC level which was correlated with administration of ziprasidone or oxcarbazepine, were increased in schizophrenic patients...
December 28, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28060910/age-associated-alu-element-instability-in-white-blood-cells-is-linked-to-lower-survival-in-elderly-adults-a-preliminary-cohort-study
#5
R Garrett Morgan, Massimo Venturelli, Cole Gross, Cantor Tarperi, Federico Schena, Carlo Reggiani, Fabio Naro, Anna Pedrinolla, Lucia Monaco, Russell S Richardson, Anthony J Donato
BACKGROUND: ALU element instability could contribute to gene function variance in aging, and may partly explain variation in human lifespan. OBJECTIVE: To assess the role of ALU element instability in human aging and the potential efficacy of ALU element content as a marker of biological aging and survival. DESIGN: Preliminary cohort study. METHODS: We measured two high frequency ALU element subfamilies, ALU-J and ALU-Sx, by a single qPCR assay and compared ALU-J/Sx content in white blood cell (WBCs) and skeletal muscle cell (SMCs) biopsies from twenty-three elderly adults with sixteen healthy sex-balanced young adults; all-cause survival rates of elderly adults predicted by ALU-J/Sx content in both tissues; and cardiovascular disease (CVD)- and cancer-specific survival rates of elderly adults predicted by ALU-J/Sx content in both tissues, as planned subgroup analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28060565/paraspeckles-as-rhythmic-nuclear-mrna-anchorages-responsible-for-circadian-gene-expression
#6
Manon Torres, Denis Becquet, Marie-Pierre Blanchard, Séverine Guillen, Bénédicte Boyer, Mathias Moreno, Jean-Louis Franc, Anne-Marie François-Bellan
Circadian clocks regulate rhythmic gene expression levels by means of mRNA oscillations that are mainly driven by post-transcriptional regulation. We identified a new post-transcriptional mechanism, which involves nuclear bodies called paraspeckles. Major components of paraspeckles including the long noncoding RNA Neat1, which is the structural component, and its major protein partners, as well as the number of paraspeckles, follow a circadian pattern in pituitary cells. Paraspeckles are known to retain within the nucleus RNAs containing inverted repeats of Alu sequences...
January 6, 2017: Nucleus
https://www.readbyqxmd.com/read/28031281/pnpase-rnase-e-g-and-ybey-are-involved-in-the-maturation-of-4-5s-rna-in-corynebacterium-glutamicum
#7
Tomoya Maeda, Yuya Tanaka, Masaaki Wachi, Masayuki Inui
: Corynebacterium glutamicum has been applied for industrial production of various metabolites such as amino acids. To understand the biosynthesis of membrane protein in this bacterium, we investigated the process of signal recognition particle (SRP) assembly. SRP is found in all three domains of life and plays an important role in the membrane insertion of proteins. SRP RNA is initially transcribed as precursor molecules; however, relatively little is known about its maturation. In C...
December 28, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/28026805/-conformational-polymorphysm-of-g-rich-fragments-of-dna-alu-repeats-ii-the-putative-role-of-g-quadruplex-structures-in-genomic-rearrangements
#8
A M Varizhuk, A V Sekridova, M V Tankevich, V S Podgorsky, I P Smirnov, G E Pozmogova
Three evolutionary conserved sites of Alu repeats (PQS2, PQS3 and PQS4) were shown to form stable inter- and intramolecular G-quadruplexes (GQs) in vitro. Structures and topologies of these GQs were elucidated using spectral methods. Self-association of G-rich Alu fragments was studied. Dimeric GQ formation from two distal identical or different putative quadruplex sites - (PQS2)2, (PQS3)2 or PQS2-PQS3 - within one lengthy DNA strand was demonstrated by a FRET-based method. Oligomer PQS4 (folded into a parallel intramolecular GQ) was shown to form stacks of quadruplexes that are stabilized by stacking interactions of external G-tetrads (this was confirmed by DOSY NMR, AFM microscopy and differential CD spectroscopy)...
November 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/27999332/functions-of-the-rna-editing-enzyme-adar1-and-their-relevance-to-human-diseases
#9
REVIEW
Chunzi Song, Masayuki Sakurai, Yusuke Shiromoto, Kazuko Nishikura
Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-stranded RNA (dsRNA). Among the three types of mammalian ADARs, ADAR1 has long been recognized as an essential enzyme for normal development. The interferon-inducible ADAR1p150 is involved in immune responses to both exogenous and endogenous triggers, whereas the functions of the constitutively expressed ADAR1p110 are variable. Recent findings that ADAR1 is involved in the recognition of self versus non-self dsRNA provide potential explanations for its links to hematopoiesis, type I interferonopathies, and viral infections...
December 17, 2016: Genes
https://www.readbyqxmd.com/read/27999136/human-muse-cells-reconstruct-neuronal-circuitry-in-subacute-lacunar-stroke-model
#10
Hiroki Uchida, Kuniyasu Niizuma, Yoshihiro Kushida, Shohei Wakao, Teiji Tominaga, Cesario V Borlongan, Mari Dezawa
BACKGROUND AND PURPOSE: Multilineage-differentiating stress-enduring (muse) cells are endogenous nontumorigenic stem cells with pluripotency harvestable as pluripotent marker SSEA-3(+) cells from the bone marrow from cultured bone marrow-mesenchymal stem cells. After transplantation into neurological disease models, muse cells exert repair effects, but the exact mechanism remains inconclusive. METHODS: We conducted mechanism-based experiments by transplanting serum/xeno-free cultured-human bone marrow-muse cells into the perilesion brain at 2 weeks after lacunar infarction in immunodeficient mice...
December 20, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27999094/the-epigenetic-landscape-of-alu-repeats-delineates-the-structural-and-functional-genomic-architecture-of-colon-cancer-cells
#11
Mireia Jordà, Anna Díez-Villanueva, Izaskun Mallona, Berta Martín, Sergi Lois, Víctor Barrera, Manel Esteller, Tanya Vavouri, Miguel A Peinado
Cancer cells exhibit multiple epigenetic changes with prominent local DNA hypermethylation and widespread hypomethylation affecting large chromosomal domains. Epigenome studies often disregard the study of repeat elements owing to technical complexity and their undefined role in genome regulation. We have developed NSUMA (Next-generation Sequencing of UnMethylated Alu), a cost-effective approach allowing the unambiguous interrogation of DNA methylation in more than 130,000 individual Alu elements, the most abundant retrotransposon in the human genome...
January 2017: Genome Research
https://www.readbyqxmd.com/read/27997106/correction-to-opportunities-and-limitations-for-nanophotonic-structures-to-exceed-the-shockley-queisser-limit
#12
Sander A Mann, Richard R Grote, Richard M Osgood, Andrea Alù, Erik C Garnett
No abstract text is available yet for this article.
December 20, 2016: ACS Nano
https://www.readbyqxmd.com/read/27994182/identification-of-a-novel-15-5-kb-shox-deletion-associated-with-marked-intrafamilial-phenotypic-variability-and-analysis-of-its-molecular-origin
#13
Angelos Alexandrou, Ioannis Papaevripidou, Kyriakos Tsangaras, Ioanna Alexandrou, Marios Tryfonidis, Violetta Christophidou-Anastasiadou, Eleni Zamba-Papanicolaou, George Koumbaris, Vassos Neocleous, Leonidas A Phylactou, Nicos Skordis, George A Tanteles, Carolina Sismani
Haploinsufficiency of the short stature homeobox contaning SHOX gene has been shown to result in a spectrum of phenotypes ranging from Leri-Weill dyschondrosteosis (LWD) at the more severe end to SHOX-related short stature at the milder end of the spectrum. Most alterations are whole gene deletions, point mutations within the coding region, or microdeletions in its flanking sequences. Here, we present the clinical and molecular data as well as the potential molecular mechanism underlying a novel microdeletion, causing a variable SHOX-related haploinsufficiency disorder in a three-generation family...
December 2016: Journal of Genetics
https://www.readbyqxmd.com/read/27982734/increased-complexity-of-circrna-expression-during-species-evolution
#14
Rui Dong, Xu-Kai Ma, Ling-Ling Chen, Li Yang
Circular RNAs (circRNAs) are broadly identified from precursor mRNA (pre-mRNA) back-splicing across various species. Recent studies have suggested a cell-/tissue- specific manner of circRNA expression. However, the distinct expression pattern of circRNAs among species and its underlying mechanism still remain to be explored. Here, we systematically compared circRNA expression from human and mouse, and found that only a small portion of human circRNAs could be determined in parallel mouse samples. The conserved circRNA expression between human and mouse is correlated with the existence of orientation-opposite complementary sequences in introns that flank back-spliced exons in both species, but not the circRNA sequences themselves...
December 16, 2016: RNA Biology
https://www.readbyqxmd.com/read/27970078/tct-699-anatomic-deployment-index-a-novel-measure-of-sapien-3-transcatheter%C3%A2-heart-valve-performance
#15
Rebecca Hahn, Maria Alu, Jonathon Leipsic, Pamela Douglas, Wael Jaber, Neil Weissman, Omar Khalique, Philipp Blanke, Rupa Parvataneni, Susheel Kodali, Vinod Thourani, Philippe Pibarot
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970068/tct-691-sex-specific-differences-after-transcatheter-or-surgical-aortic-valve-replacement-in-intermediate-risk-patients-an-analysis-from-the-partner-2-randomized-trial
#16
Jonathan White, Darshan Doshi, Mathew Williams, Molly Szerlip, John Squiers, John Webb, Rebecca Hahn, Ajay Kirtane, Claire Litherland, David Cohen, E Murat Tuzcu, Wilson Szeto, Alan Zajarias, S Chris Malaisrie, Maria Alu, Craig Smith, Martin Leon, Michael Mack, Susheel Kodali
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970058/tct-679-diabetes-and-clinical-outcomes-in-intermediate-risk-patients-randomized-to-transcatheter-versus-surgical-aortic-valve-replacement-an-analysis-of-the-partner-2a-trial
#17
Brian Lindman, Yigal Abramowitz, Philippe Pibarot, Nishath Quader, Hersh Maniar, Alan Zajarias, Suzanne Arnold, Rebecca Hahn, Sammy Elmariah, Rakesh Suri, Torsten Vahl, Lars Svensson, Vinod Thourani, Claire Litherland, Maria Alu, Martin Leon, Raj Makkar
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970050/tct-674-sex-specific-outcomes-of-tavr-with-the-sapien-3-valve-insights-from-the-partner-2-s3-high-risk-and-intermediate-risk-cohorts
#18
Molly Szerlip, Sarah Gualano, John Squiers, Jonathon White, Darshan Doshi, Isaac George, Nicolas Vazquez, John Michael Dimaio, Raj Makkar, Mathew Williams, Howard Herrmann, Lars Svensson, John Webb, Rebecca Hahn, Ajay Kirtane, Vasilis Babaliaros, Vinod Thourani, Maria Alu, Susheel Kodali, Martin Leon, Michael Mack
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970038/tct-661-the-clinical-impact-of-diabetes-mellitus-on-outcomes-after-transcatheter-aortic-valve-replacement-insights-from-the-partner-ii-sapien-3-cohort
#19
Yigal Abramowitz, Brian Lindman, Tarun Chakravarty, Hasanian Jilaihawi, Samir Kapadia, Wilson Szeto, Philippe Pibarot, Vasilis Babaliaros, Howard Herrmann, Richard Smalling, Lars Svensson, Torsten Vahl, Vinod Thourani, Susheel Kodali, Craig Smith, Yiran Zhang, Maria Alu, Michael Mack, Martin Leon, Raj Makkar
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969687/tct-34-effect-of-sapien-3-transcatheter-valve-implant-on-health-status-in-patients-with-severe-aortic-stenosis-at-intermediate-surgical-risk-results-from-the-partner-s3i-trial
#20
Suzanne Baron, Maria Alu, Vinod Thourani, Susheel Kodali, Suzanne Arnold, Khaja Chinnakondepali, Elizabeth Magnuson, Kaijun Wang, Augusto Pichard, Vasilis Babaliaros, Isaac George, D Craig Miller, E Murat Tuzcu, Kevin Greason, Howard Herrmann, Craig Smith, Martin Leon, David Cohen
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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