Read by QxMD icon Read


Brittany M A Salter, Steven G Smith, Manali Mukherjee, Sophie Plante, Sakktee Krisna, Graeme Nusca, John Paul Oliveria, Anam Irshad, Gail M Gauvreau, Jamila Chakir, Parameswaran Nair, Roma Sehmi
Activated bronchial epithelial cells (BEC) release various alarmins, including thymic stromal lymphopoietin (TSLP), that drive type 2 inflammation. We hypothesize that BEC-derived factors promote in situ eosinophil differentiation and maturation, a process that is driven by an IL-5-rich microenvironment in asthmatic airways. To assess the eosinophilopoietic potential of epithelial-derived factors, eosinophil/basophil colony forming units (Eo/B-CFU) were enumerated in 14-day methylcellulose cultures of blood-derived nonadherent mononuclear cells incubated with BEC supernatants (BECSN) from healthy nonatopic controls (n = 8), mild atopic asthmatics (n = 9), and severe asthmatics (n = 5)...
January 2018: American Journal of Respiratory Cell and Molecular Biology
Jehison Jiménez Hernández, María Inés Ragone, Patricia Bonazzola, Arnaldo L Bandoni, Alicia E Consolini
ETHNOPHARMACOLOGY RELEVANCE: Blepharocalyx salicifolius (Kunth) O. Berg (Myrtaceae) is a tree native to Argentina and Uruguay that grows and is cultivated along the riverside of the Rio de la Plata. The leaves of this plant species, locally known as "anacahuita" are used in South America to prepare infusions for the empiric treatment of cough and bronchospasm, as well as diarrhoea and other intestinal disorders. Although previous phytochemical studies have been performed with the essential oil extracted from Blepharocalyx salicifolius, pharmacological evidence supporting its traditional use is still lacking...
August 12, 2017: Journal of Ethnopharmacology
Zuzana Kovacikova, Katerina Neumannova, Jana Rydlova, Lucia Bizovská, Miroslav Janura
OBJECTIVE: Pulmonary rehabilitation is mainly focused on exercise training and breathing retraining in children with asthma. Conversely, balance training is not usually recommended for the treatment, although postural deficits were found in these patients. Therefore, this study assessed the effect of balance training intervention on postural stability in children with asthma. METHODS: Nineteen children with mild intermittent asthma (age 11.1 ± 2.1 years, height 147...
July 12, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Zlatica Goseva, Elena Jovanovska Janeva, Angelko Gjorcev, Zoran Arsovski, Sava Pejkovska
BACKGROUND: Asthma is characterized by airway inflammation which can be reversible. AIM: Investigation the importance of eosinophils, ECP and IL-5 in asthmatics versus patients with obstructive bronchitis and healthy subjects. We investigated the values before and after the treatment in asthmatics. MATERIAL AND METHODS: We studied 77 subjects divided in three groups as follows: 1) asthma patients; 2) patients with obstructive bronchitis and 3) control group of healthy subjects...
December 15, 2015: Open Access Macedonian Journal of Medical Sciences
Neel Heerasing, Shok Yin Lee, Sina Alexander, Damian Dowling
AIM: To look at the relationship between eosinophilic oesophagitis (EO) and food bolus impaction in adults. METHODS: We retrospectively analysed medical records of 100 consecutive patients who presented to our hospital with oesophageal food bolus obstruction (FBO) between 2012 and 2014. In this cohort, 96 were adults (64% male), and 4 paediatric patients were excluded from the analysis as our centre did not have paediatric gastroenterologists. Eighty-five adult patients underwent emergency gastroscopy...
November 6, 2015: World Journal of Gastrointestinal Pharmacology and Therapeutics
Zuzana Kovacikova, Katerina Neumannova, Lucia Bizovska, Jana Rydlova, Martin Siska, Miroslav Janura
OBJECTIVE: This study assessed the postural stability in children with asthma using balance tests under conditions of a comfortable foot placement and with a foot placement provoking instability. METHODS: A group of 10 school children from 8 to 10 years old with mild intermittent asthma and 10 healthy children of the same age range performed four balance tests in a randomized order: preferred stance, adjusted stance, and tandem stance each under both conditions of eyes opened (EO) and eyes closed (EC), as well as a one-legged stance with eyes-opened conditions...
2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Joaquín Salas-Coronas, María Teresa Cabezas-Fernández, José Vázquez-Villegas, Manuel Jesús Soriano-Pérez, Ana Belén Lozano-Serrano, Inés Pérez-Camacho, María Isabel Cabeza-Barrera, Fernando Cobo
OBJECTIVE: To determine the etiology of eosinophilia in immigrant patients in Southern Spain. METHODS: Prospective study of immigrant patients with eosinophilia (> 500 Eo/μL) attended in a reference Tropical Medicine Unit and evaluated through the implementation of a specific protocol structured in different levels meant to be accomplished depending on the findings of each previous level. RESULTS: Out of the 549 patients included in the study (89...
July 2015: Travel Medicine and Infectious Disease
Geoffrey Mortuaire, Isabelle Gengler, Claire Vandenhende-Szymanski, Marie Delbeke, Solène Gatault, Dominique Chevalier, Lionel Prin, Monique Capron
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is frequently associated with asthma. Mucosal eosinophil (EO) infiltrate has been found to correlate with asthma and disease severity but not necessarily in every patient. Other multifactorial immune processes are required to determine disease endotypes and response to treatment. OBJECTIVE: To evaluate EO immunomodulation for migration and survival in accordance with inflammatory protein profiles and asthmatic status in CRSwNP...
April 2015: Annals of Allergy, Asthma & Immunology
Steven G Smith, Mike Hill, John-Paul Oliveria, Brittany M Watson, Adrian J Baatjes, Benny Dua, Karen Howie, Heather Campbell, Rick M Watson, Roma Sehmi, Gail M Gauvreau
Peroxisome proliferator-activated receptor (PPAR) agonists have been suggested as novel therapeutics for the treatment of inflammatory lung disease, such as allergic asthma. Treatment with PPAR agonists has been shown to inhibit airway eosinophilia in murine models of allergic asthma, which can occur through several mechanisms including attenuated generation of chemoattractants (e.g. eotaxin) and decreased eosinophil migrational responses. In addition, studies report that PPAR agonists can inhibit the differentiation of several cell types...
July 2014: Immunology
Y Ma, X Liu, Z Wei, X Wang, Z Wang, W Zhong, Y Li, F Zhu, C Guo, L Zhang, X Wang
Tumour necrosis factor-α-induced protein-8 like-2 (TIPE2) is a newly identified immune negative regulator. The abnormal expression of TIPE2 has been found in several human inflammatory diseases. However, the expression level and clinical significance of TIPE2 in childhood asthma remain unclear. In this study, we detected TIPE2 expression in peripheral blood mononuclear cells (PBMC) from 42 children with asthma and 39 healthy controls by RT-PCR, qRT-PCR and Western blot. We also detected the levels of serum total immunoglobulin E (IgE), eosinophil (EO), interleukin-4 (IL-4) and interferon-γ (IFN-γ) and analysed the correlations of TIPE2 expression with IgE, EO, IL-4 and IFN-γ...
December 2013: Scandinavian Journal of Immunology
Jonathan P Arm, Joshua A Boyce, Lin Wang, Heng Chhay, Muhammad Zahid, Vaishali Patil, Usha Govindarajulu, Priscilla Ivester, Kelly L Weaver, Susan Sergeant, Elliot Israel, Floyd H Chilton
BACKGROUND: Dietary supplementation with botanical oils that contain n-6 and n-3 eighteen carbon chain (18C)-PUFA such as γ linolenic acid (GLA, 18:3n-6), stearidonic acid (SDA, 18:4n-3) and α linolenic acid (ALA, 18:3n-3) have been shown to impact PUFA metabolism, alter inflammatory processes including arachidonic acid (AA) metabolism and improve inflammatory disorders. METHODS: The diet of mild asthmatics patients was supplemented for three weeks with varying doses of two botanical seed oils (borage oil [Borago officinalis, BO] and echium seed oil [Echium plantagineum; EO]) that contain SDA, ALA and GLA...
October 2, 2013: Lipids in Health and Disease
Peter Mannon, Walter Reinisch
Interleukin 13 (IL-13) is a cytokine of increasing interest to gastroenterologists because of its developing role in ulcerative colitis, eosinophilic oesophagitis (EO) and fibrosis. Recent data show that IL-13 may play an important role in a novel innate immune response since it can be released by signals from an injured or inflamed epithelium, of particular relevance to the gut. Animal models of IL-13-driven inflammation (from asthma to colitis and EO) are being translated to human disease and providing insight into potential strategies for new therapies...
December 2012: Gut
Leticia Lintomen, Marina C Calixto, André Schenka, Edson Antunes
Asthma and obesity are growing epidemics in the world. It is well established that obesity worsens the asthma outcomes. High-fat diet-induced obesity in mice exacerbates the pulmonary eosinophilic inflammation. We have used wild-type (WT) and ob/ob mice to further explore the mechanisms by which obesity aggravates the pulmonary eosinophilic inflammation. The eosinophil (EO) number in bronchoalveolar lavage (BAL) fluid, lung tissue, blood, and bone marrow were evaluated at 24, 48, and 72 h after ovalbumin (OVA) challenge in sensitized mice...
October 2012: Obesity
D Monbaliu, A Van Breussegem, A Onsia, E Vandermeersch, C Segers, W Meert, A-M Kochuyt, J Pirenne, K Claes
Ethylene oxide (EO) is widely used as a sterilization gas for heat-sensitive devices. In EO-sensitized patients, this type of sterilization can cause rare but major allergic reactions such as hives, rash, asthma, or anaphylactic shock. Hemodialysis patients in particular are at risk of developing hypersensitivity to EO. In these patients, surgical interventions should be planned far in advance allowing a thorough EO-free preparation of all equipment needed for the surgery as well as for the pre-, peri-, and postoperative care...
December 2010: Transplantation Proceedings
Pia Reece, Amudhinie Thanendran, Lynn Crawford, Meri K Tulic, Lehana Thabane, Susan L Prescott, Roma Sehmi, Judah A Denburg
BACKGROUND: Little is known regarding the prenatal determinants of innate immune responses in relation to infant allergic risk. Environmental exposures, including microbial stimuli, might predispose susceptible subjects to atopy and asthma in early infancy or even in utero. OBJECTIVE: Because Toll-like receptors (TLRs) recognize microbial products and because cord blood (CB) progenitor alterations have been observed in neonates at risk for atopy, we investigated the expression and function of TLRs on CB hematopoietic progenitors in relation to atopic risk, as defined by maternal allergic sensitization...
February 2011: Journal of Allergy and Clinical Immunology
Gulfidan Aras, Kursat Yelken, Dilek Kanmaz, Omer Develioglu, Osman Mavis, Erdogan Gultekin, Aysenur Akyildiz Igdem, Sevim Purisa
OBJECTIVES: To determine whether erosive esophagitis (EO) worsens reflux signs and symptoms and affects pulmonary function test in asthma patients. METHODS: Sixty asthma patients with gastroesophageal and laryngopharyngeal reflux symptoms were included. Spirometry, reversibility test, esophagogastroscopy, laryngoscopy, and esophagogastroscopic biopsies were conducted. RESULTS: EO was diagnosed in 25% (n = 15) of the patients. The remaining 45 patients were placed into the non-erosive esophagitis (NEO) group...
December 2010: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Richard D O'Connor, Eugene R Bleecker, Aidan Long, Donald Tashkin, Stephen Peters, David Klingman, Benjamin Gutierrez
BACKGROUND: Monitoring indicators of subacute lack of asthma control (SALAC) may help to reduce asthma morbidity. OBJECTIVE: To determine whether SALAC, independent of current asthma exacerbations, is associated with subsequent acute asthma exacerbations. METHODS: Administrative claims data from PharMetrics/IMS Health were used to identify patients 12 years or older continuously enrolled in a participating U.S. health plan from 2001 to 2004 with >or=1 asthma claim (International Classification of Diseases, Ninth Revision, Clinical Modification code 493...
May 2010: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Angela E Sadlon, Davis W Lamson
Eucalyptus oil (EO) and its major component, 1,8-cineole, have antimicrobial effects against many bacteria, including Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus (MRSA), viruses, and fungi (including Candida). Surprisingly for an antimicrobial substance, there are also immune-stimulatory, anti-inflammatory, antioxidant, analgesic, and spasmolytic effects. Of the white blood cells, monocytes and macrophages are most affected, especially with increased phagocytic activity. Application by either vapor inhalation or oral route provides benefit for both purulent and non-purulent respiratory problems, such as bronchitis, asthma, and chronic obstructive pulmonary disease (COPD)...
April 2010: Alternative Medicine Review: a Journal of Clinical Therapeutic
Mohammad Reza Khakzad, Majid Mirsadraee, Mojtaba Sankian, Abdolreza Varasteh, Mojtaba Meshkat
Spirometry has been used as a common diagnostic test in asthma. Most of the patients with a mild asthma have a FEV1 within normal range. Hence, other diagnostic methods are usually used. The aim of this study was to evaluate whether eosinophil Cationic Protein (ECP) could be an accurate diagnostic marker of mild asthma. In this study diagnosis of asthma was made according to internationally accepted criteria. Asthma severity was evaluated according to frequency of symptoms and FEV1.Adequate sputum samples were obtained in 50 untreated subjects...
September 2009: Iranian Journal of Allergy, Asthma, and Immunology
D Ford, W Kim Seow, S Kazoullis, T Holcombe, B Newman
PURPOSE: The purpose of this study was to investigate risk factors for enamel hypoplasia (EH) and enamel opacity (EO) in the permanent teeth of healthy schoolchildren from a nonfluoridated community in Australia. METHODS: Children with EH (N=104) or EO (N=104) were compared with matched controls without enamel defects (N=105). Subjects who previously resided in on optimally fluoridated town provided data on the effects of drinking fluoridated water. RESULTS: The main risk factors for EH were low socioeconomic status (P < ...
September 2009: Pediatric Dentistry
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"