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https://www.readbyqxmd.com/read/27875921/a-retrospective-review-of-paediatric-adverse-drug-reactions-reported-in-lombardy-and-croatia-from-2005-to-2013
#1
Carla Carnovale, Marta Gentili, Marco Matacena, Marina Dimov Di Giusti, Darko Krnic, Barbara Dolinic, Darija Kolaric, Zeljana Margan Koletic, Viola Macolic Sarinic, Maja Culjak, Ida Fortino, Luca Merlino, Emilio Clementi, Sonia Radice
OBJECTIVE: to characterise the adverse drugs reactions (ADRs) reported in the Lombard and Croatian paediatric population and to compare data to specific paediatric age groups, in terms of trend, pattern and severity of ADRs, increasing understanding of paediatric ADRs. RESEARCH DESIGN AND METHODS: We selected and analysed all the spontaneous reports in which children were involved (0 < 18 years old) reported in the Lombardy and in Croatian pharmacovigilance databases from 1(th) March 2005 to 31(th) December 2013...
December 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27382385/molecular-portrait-of-the-normal-human-breast-tissue-and-its-influence-on-breast-carcinogenesis
#2
REVIEW
Madalin Marius Margan, Andreea Adriana Jitariu, Anca Maria Cimpean, Cristian Nica, Marius Raica
Normal human breast tissue consists of epithelial and nonepithelial cells with different molecular profiles and differentiation grades. This molecular heterogeneity is known to yield abnormal clones that may contribute to the development of breast carcinomas. Stem cells that are found in developing and mature breast tissue are either positive or negative for cytokeratin 19 depending on their subtype. These cells are able to generate carcinogenesis along with mature cells. However, scientific data remains controversial regarding the monoclonal or polyclonal origin of breast carcinomas...
June 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/27186210/effective-strategies-for-reducing-maternal-mortality-in-isfahan-university-of-medical-sciences-2014
#3
Somaye Nosraty, Mojtaba Rahimi, Shahnaz Kohan, Margan Beigei
BACKGROUND: Maternal mortality rate is among the most important health indicators. This indicator is a function of factors that are related to pregnant women; these factors include economic status, social and family life of the pregnant woman, human resources, structure of the hospitals and health centers, and management factors. Strategic planning, with a comprehensive analysis and coverage of all causes of maternal mortality, can be helpful in improving this indicator. MATERIALS AND METHODS: This research is a descriptive exploratory study...
May 2016: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/26898074/sexually-transmitted-diseases-as-a-risk-for-acquiring-hiv-infection-among-the-population-of-men-who-have-sex-with-men-a-case-control-study
#4
Danijela Lakoseljac, Ira Gjenero-Margan, Branko Kolarić, Tomislav Rukavina, Tatjana Nemeth Blazić
At the beginning of the 1980-ies, HIV infection and AIDS were described for the first time, this among the population of men who have sex with other men. Nearly thirty years later, the MSM population is still a population under heightened risk for acquiring HIV infection and other sexually transmitted diseases. This study investigates sexually transmitted diseases as a risk for HIV infection. A total of 296 men who have sex with men (MSM) were included in this case control study. Differences among the frequencies of sexually transmitted diseases among the MSM of HIV positive and HIV negative status were tested...
September 2015: Collegium Antropologicum
https://www.readbyqxmd.com/read/26339876/-acth-s-ectopic-secretion-in-a-patient-with-precedents-of-cushing-s-disease
#5
Agustín Dal Verme, Carlos Cejas, Mercedes Margan, Daniel Siguelboim, Victoria Canosa, Christian Peralta
A 54-year-old man, with a history of Cushing's disease diagnosed 32 years earlier, presented with edema, asthenia and general malaise. Abnormal laboratory studies depicted hypokalemia and metabolic alkalosis. A CT scan of the chest revealed a 3×3 cm tumor in the anterior mediastinum. The pathology was consistent with a thymic carcinoid. These findings led to a diagnosis of biochemical Cushing's syndrome secondary to ectopic secretion of ACTH. Thus, this patient suffered twice of Cushing's syndrome. The first instance was the consequence of an ACTH--secreting pituitary adenoma and the second of an ectopic secretion of ACTH...
2015: Medicina
https://www.readbyqxmd.com/read/26132839/seroprevalence-and-entomological-study-on-chikungunya-virus-at-the-croatian-littoral
#6
Tatjana Vilibic-Cavlek, Iva Pem-Novosel, Bernard Kaic, Andrea Babić-Erceg, Jasmina Kucinar, Ana Klobucar, Alan Medic, Djana Pahor, Katija Barac-Juretic, Ira Gjenero-Margan
During 2011-2012, a total of 1008 serum samples from randomly selected inhabitants of seven Croatian counties located on the Adriatic Coast were tested for the presence of chikungunya virus (CHIKV) IgG antibodies using indirect immunofluorescence assay. Nine participants (0.9%) from four counties were found to be seropositive to CHIKV. Seroprevalence varied from 0.5% to 1.8% between counties. Additionally, a total of 3,699 mosquitoes were captured in 126 localities from August 16 to September 24, 2011. Three mosquito species were found: Ae...
June 2015: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/26117611/-facial-diplegia-with-atypical-paresthesia-a-variant-of-guillain-barr%C3%A3-syndrome
#7
Agustín Dal Verme, Paula Acosta, Mercedes Margan, Cecilia Pagnini, Eugenia Dellepiane, Christian Peralta
Guillain-Barré syndrome is an acute demyelinating disease which presents in a classic form with muscular weakness and the lack of reflexes. There are multiple variations and atypical forms of the disease, being facial diplegia with paresthesia one of them. Also, the absence of reflexes in this syndrome is typical but not constant, since 10% of patients present reflexes. We describe a case of atypical presentation with bilateral facial palsy, paresthesia, brisk reflexes and weakness in the lower limbs in a 33 year old woman...
2015: Medicina
https://www.readbyqxmd.com/read/25821943/dengue-virus-infection-in-croatia-seroprevalence-and-entomological-study
#8
Iva Pem-Novosel, Tatjana Vilibic-Cavlek, Ira Gjenero-Margan, Bernard Kaic, Andrea Babic-Erceg, Enrih Merdic, Alan Medic, Miljenko Ljubic, Djana Pahor, Marijan Erceg
During 2011-2012, a total of 1,180 sera samples were collected from residents of seven Croatian counties located on the Adriatic Coast and four counties in northeastern Croatia and tested for the presence of dengue virus (DENV) IgG antibodies using ELISA. Reactive samples were further tested by IFA. Seven samples (0.59%) tested positive for DENV antibodies. Seroprevalence rates by county varied from 0-2.21%. The highest seropositivity rate (2.21%) was found in the Dubrovnik-Neretva County where autochthonous dengue cases were recorded in 2010...
January 2015: New Microbiologica
https://www.readbyqxmd.com/read/25667455/differential-expression-of-e-cadherin-in-primary-breast-cancer-and-corresponding-lymph-node-metastases
#9
Veaceslav Fulga, Lucian Rudico, Amalia Raluca Balica, Anca Maria Cimpean, Lilian Saptefrati, Madalin-Marius Margan, Marius Raica
BACKGROUND/AIM: E-Cadherin is a marker with a controversial function. Its role is often interpreted in the context of the epithelial-mesenchymal transition. In ambiguous cases, it is used as a phenotypic marker of lobular subtype of breast carcinoma. It has been well-studied in primary cancer, but its expression after metastasis is not well-described. The aim of this study was to determine the evolution of E-cadherin expression in no special type (NST) primary breast carcinoma and to correlate this with that in distant, paired nodal metastases (LNM) and molecular classification...
February 2015: Anticancer Research
https://www.readbyqxmd.com/read/25567212/influenza-vaccine-effectiveness-estimates-in-croatia-in-2010-2011-a-season-with-predominant-circulation-of-a-h1n1-pdm09-influenza-virus
#10
S Kurečić Filipović, I Gjenero-Margan, E Kissling, B Kaić, A Cvitković
This is a retrospective study using the test-negative case-control method to estimate seasonal 2010-2011 influenza vaccine effectiveness (VE) in Croatia. Of patients consulting a physician for influenza-like illness (ILI) and for whom a swab was taken, we compared RT-PCR influenza-positive and RT-PCR influenza-negative patients. We used a structured questionnaire and physicians' records to obtain information on vaccination status and potential confounders. We conducted a complete case analysis using logistic regression to measure adjusted VE overall, against A(H1N1)pdm09 and in age groups...
September 2015: Epidemiology and Infection
https://www.readbyqxmd.com/read/24984326/-epidemiology-of-viral-hepatitis
#11
Bernard Kaić, Tatjana Vilibić-Cavlek, Sanja Kurecić Filipović, Tatjana Nemeth-Blazić, Iva Pem-Novosel, Vesna Visekruna Vucina, Aleksandar Simunović, Martina Zajec, Ivan Radić, Jasmina Pavlić, Marica Glamocanin, Ira Gjenero-Margan
Understanding the country-specific epidemiology of disease, which may vary greatly among countries, is crucial for identifying the most appropriate preventive and control measures. An overview of the local epidemiology of viral hepatitis in Croatia is given in this paper. The overall prevalence of hepatitis B in Croatia is low (less than 2% HBsAg carriers in the general population). Hepatitis B incidence and prevalence began to decline significantly following the introduction of universal hepatitis B vaccination in 1999...
October 2013: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
https://www.readbyqxmd.com/read/24793998/first-evidence-of-simultaneous-occurrence-of-west-nile-virus-and-usutu-virus-neuroinvasive-disease-in-humans-in-croatia-during-the-2013-outbreak
#12
T Vilibic-Cavlek, B Kaic, L Barbic, I Pem-Novosel, V Slavic-Vrzic, V Lesnikar, S Kurecic-Filipovic, A Babic-Erceg, E Listes, V Stevanovic, I Gjenero-Margan, G Savini
PURPOSE: We report on first evidence of simultaneous occurrence of West Nile virus (WNV) and Usutu virus (USUV) neuroinvasive infection in humans in Croatia during the transmission season 2013. METHODS: From June to December 2013, a total of 95 patients with clinically suspected WNV infection (WNV fever and neuroinvasive disease) were tested for WNV IgM/IgG antibodies using enzyme-linked immunosorbent assay. Twenty-six reactive samples were further tested by virus neutralization test for confirmation...
August 2014: Infection
https://www.readbyqxmd.com/read/24283515/first-outbreak-of-west-nile-virus-neuroinvasive-disease-in-humans-croatia-2012
#13
Iva Pem-Novosel, Tatjana Vilibic-Cavlek, Ira Gjenero-Margan, Nenad Pandak, Ljiljana Peric, Ljubo Barbic, Eddy Listes, Ante Cvitkovic, Vladimir Stevanovic, Giovanni Savini
Between September 6 and 21, 2012, seven human cases of West Nile virus (WNV) neuroinvasive infection were laboratory confirmed in Croatia. The median patient age was 62 years (range 48-77). Five patients presented with meningoencephalitis and two patients with meningoencephalitis followed by acute flaccid paralysis. Four of them had an underlying disease (hypertension). Using enzyme-linked immunosorbent assay (ELISA), WNV-specific immunoglobulin M (IgM) and IgG antibodies of low avidity were detected in six patients, whereas one showed only IgM antibodies...
January 2014: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/23898697/-west-nile-virus-infection-re-emergent-disease-in-croatia
#14
REVIEW
Tatjana Vilibić-Cavlek, Ljubo Barbić, Suncanica Ljubin-Sternak, Iva Pem-Novosel, Vladimir Stevanović, Ira Gjenero-Margan, Gordana Mlinarić-Galinović
West Nile virus (WNV) is a small, enveloped, spherical virus that belongs to the family Flaviviridae, genus Flavivirus, Japanese encephalitis serocomplex. Natural reservoirs of WNV are birds, and the main vectors are mosquitoes of the genus Culex. There are seven genetic lineages of WNV. Lineages 1 and 2 are the most widely distributed (Africa, North and South America, Europe, Asia and Australia). About 80% of infections are asymptomatic. In 20% of patients nonspecific febrile disease occurs (West Nile fever)...
May 2013: Lijec̆nic̆ki Vjesnik
https://www.readbyqxmd.com/read/23808977/demonstration-of-usutu-virus-antibodies-in-horses-croatia
#15
Ljubo Barbic, Tatjana Vilibic-Cavlek, Eddy Listes, Vladimir Stevanovic, Ira Gjenero-Margan, Suncanica Ljubin-Sternak, Iva Pem-Novosel, Irena Listes, Gordana Mlinaric-Galinovic, Annapia Di Gennaro, Giovanni Savini
We report the first serological evidence of Usutu virus (USUV) infection in horses in Croatia. During 2011, 1380 horse serum samples from healthy animals were collected from six northern Croatian counties. All samples were first screened for West Nile virus (WNV) immunoglobulin G (IgG) antibodies using an enzyme-linked immunosorbent assay (ELISA). Sixty-nine WNV ELISA-reactive samples were further tested for WNV antibodies by a virus neutralization assay (VN assay) and plaque reduction neutralization test (PRNT), and USUV by a VN assay and tick-borne encephalitis virus (TBEV) antibodies by PRNT...
October 2013: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/22132075/multiple-cytokines-are-released-when-blood-from-patients-with-tuberculosis-is-stimulated-with-mycobacterium-tuberculosis-antigens
#16
Kathryn L Kellar, Jennifer Gehrke, Stephen E Weis, Aida Mahmutovic-Mayhew, Blachy Davila, Margan J Zajdowicz, Robin Scarborough, Philip A LoBue, Alfred A Lardizabal, Charles L Daley, Randall R Reves, John Bernardo, Brandon H Campbell, William C Whitworth, Gerald H Mazurek
BACKGROUND: Mycobacterium tuberculosis (Mtb) infection may cause overt disease or remain latent. Interferon gamma release assays (IGRAs) detect Mtb infection, both latent infection and infection manifesting as overt disease, by measuring whole-blood interferon gamma (IFN-γ) responses to Mtb antigens such as early secreted antigenic target-6 (ESAT-6), culture filtrate protein 10 (CFP-10), and TB7.7. Due to a lack of adequate diagnostic standards for confirming latent Mtb infection, IGRA sensitivity for detecting Mtb infection has been estimated using patients with culture-confirmed tuberculosis (CCTB) for whom recovery of Mtb confirms the infection...
2011: PloS One
https://www.readbyqxmd.com/read/21755727/epidemiological-patterns-of-tuberculosis-in-croatia-in-the-period-1996-2005
#17
Anamarija Jurcev-Savicević, Vera Katalinić-Janković, Ira Gjenero-Margan, Aleksandar Simunović, Dordija Vidić, Jerko Gunjaca, Mihaela Obrovac
The last comprehensive publication on tuberculosis in Croatia and the earliest impact of war, besides the yearly routine reports, was done in 1996 in Croatian. We were, therefore, interested to explore incidence trends and to highlight the early post-war tuberculosis epidemiological patterns in the next ten years period (1996-2005). A retrospective analysis of epidemiological data on all registered tuberculosis cases in Croatia searching the databases of 21 Croatian Public Health Institutes and the National Tuberculosis Registry was made...
June 2011: Collegium Antropologicum
https://www.readbyqxmd.com/read/21632018/outbreak-of-hand-foot-and-mouth-disease-caused-by-coxsackie-a16-virus-in-a-childcare-centre-in-croatia-february-to-march-2011
#18
S Ljubin-Sternak, V Slavic-Vrzic, T Vilibić-Čavlek, B Aleraj, I Gjenero-Margan
We describe an outbreak of hand, foot and mouth disease (HFMD) in a childcare centre in a district of Zagreb county, north-west Croatia. A total of eleven cases of HFMD occurred in the childcare centre and another nine were reported from nearby areas in the district. Coxsackie A16 virus was diagnosed in 13 clinical specimens obtained from 11 symptomatic and asymptomatic children. All cases resolved without complications.
2011: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/21392489/autochthonous-dengue-fever-in-croatia-august-september-2010
#19
I Gjenero-Margan, B Aleraj, D Krajcar, V Lesnikar, A Klobučar, I Pem-Novosel, S Kurečić-Filipović, S Komparak, R Martić, S Duričić, L Betica-Radić, J Okmadžić, T Vilibić-Čavlek, A Babić-Erceg, B Turković, T Avsić-Županc, I Radić, M Ljubić, K Sarac, N Benić, G Mlinarić-Galinović
After information about a dengue case in Germany acquired in Croatia, health professionals and the public in Croatia were alerted to assess the situation and to enhance mosquito control, resulting in the diagnosis of a second case of autochthonous dengue fever in the same area and the detection of 15 persons with evidence of recent dengue infection. Mosquito control measures were introduced. The circumstances of dengue virus introduction to Croatia remain unresolved.
2011: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/20822734/spotlight-on-measles-2010-excretion-of-vaccine-strain-measles-virus-in-urine-and-pharyngeal-secretions-of-a-child-with-vaccine-associated-febrile-rash-illness-croatia-march-2010
#20
B Kaic, I Gjenero-Margan, B Aleraj, T Vilibic-Cavlek, M Santak, A Cvitković, T Nemeth-Blazic, I Ivic Hofman
We describe excretion of measles vaccine strain Schwarz in a child who developed a febrile rash illness eight days after primary immunisation against measles, mumps and rubella. Throat swabs and urine specimens were collected on the fifth and sixth day of illness, respectively. Genotyping demonstrated measles vaccine strain Schwarz (genotype A). If measles and rubella were not under enhanced surveillance in Croatia, the case would have been either misreported as rubella or not recognised at all.
September 2, 2010: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
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