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burden dengue

B Mishra, B Behera
Until now, known as the demure cousin of dengue virus (DENV) inhabiting Africa, Zika virus (ZIKV) has reinvented itself to cause explosive epidemics captivating the Western hemisphere. The outbreak causing potential for ZIKV was realized when it made its way from Africa to Yap Island Micronesia in 2007, and in French Polynesia in 2013. From there, it moved on to Brazil in 2015. Now ZIKV has infected people in more than 33 countries in Central and South America and the Caribbean. Moreover the epidemiological and subsequent virological association with microcephaly cases in Brazil has prompted the World Health Organization to declare a public health emergency of International Concern...
October 2016: Journal of Postgraduate Medicine
Prabhu Nagnathappa Kasture, K H Nagabhushan, Arun Kumar
INTRODUCTION: Dengue is a rapidly expanding global health problem. Approximately 2.5 billion people live in dengue-risk regions with about 100 million new cases each year worldwide. The cumulative dengue diseases burden has attained an unprecedented proportion in recent times with sharp increase in the size of human population at risk. The management of dengue virus infection is essentially supportive and symptomatic and no specific treatment is available for increasing the fallen platelets, which have a significant role in causing the mortality of dengue patient...
June 2016: Journal of the Association of Physicians of India
(no author information available yet)
BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures. METHODS: We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010...
October 8, 2016: Lancet
Ipsita Mohanty, Animesha Rath, Namita Mahapatra, Rupenangshu K Hazra
Vector-borne diseases particularly those transmitted by mosquitoes like Dengue are among the leading causes of mortality and morbidity in human population. There are no effective vaccines or treatment against dengue fever till date and the control methods are limited. So, new approaches are urgently in need to reverse these trends. Vector control is currently the primary intervention tool. Strategies that reduce or block pathogen transmission by mosquitoes have been proposed as a means of augmenting current control measures to reduce the growing burden of vector-borne diseases...
July 2016: Journal of Vector Borne Diseases
José Lourenço, Mario Recker
Dengue is one of the most important and wide-spread viral infections affecting human populations. The last few decades have seen a dramatic increase in the global burden of dengue, with the virus now being endemic or near-endemic in over 100 countries world-wide. A recombinant tetravalent vaccine candidate (CYD-TDV) has recently completed Phase III clinical efficacy trials in South East Asia and Latin America and has been licensed for use in several countries. The trial results showed moderate-to-high efficacies in protection against clinical symptoms and hospitalisation but with so far unknown effects on transmission and infections per se...
September 2016: Epidemics
Elvina Viennet, Scott A Ritchie, Craig R Williams, Helen M Faddy, David Harley
Dengue has a negative impact in low- and lower middle-income countries, but also affects upper middle- and high-income countries. Despite the efforts at controlling this disease, it is unclear why dengue remains an issue in affluent countries. A better understanding of dengue epidemiology and its burden, and those of chikungunya virus and Zika virus which share vectors with dengue, is required to prevent the emergence of these diseases in high-income countries in the future. The purpose of this review was to assess the relative burden of dengue in four high-income countries and to appraise the similarities and differences in dengue transmission...
September 2016: PLoS Neglected Tropical Diseases
Siwi P M Wijayanti, Thibaud Porphyre, Margo Chase-Topping, Stephanie M Rainey, Melanie McFarlane, Esther Schnettler, Roman Biek, Alain Kohl
BACKGROUND: Dengue is a major mosquito-borne viral disease and an important public health problem. Identifying which factors are important determinants in the risk of dengue infection is critical in supporting and guiding preventive measures. In South-East Asia, half of all reported fatal infections are recorded in Indonesia, yet little is known about the epidemiology of dengue in this country. METHODOLOGY/PRINCIPAL FINDINGS: Hospital-reported dengue cases in Banyumas regency, Central Java were examined to build Bayesian spatial and spatio-temporal models assessing the influence of climatic, demographic and socio-economic factors on the risk of dengue infection...
September 2016: PLoS Neglected Tropical Diseases
Laurent Coudeville, Nicolas Baurin, Maïna L'Azou, Bruno Guy
BACKGROUND: A tetravalent dengue vaccine demonstrated its protective efficacy in two phase III efficacy studies. Results from these studies were used to derive vaccination impact in the five Asian (Indonesia, Malaysia, Philippines, Thailand, Vietnam) and the five Latin American countries (Brazil, Colombia, Honduras, Mexico and Puerto Rico) participating in these trials. METHODS: Vaccination impact was investigated with an age-structured, host-vector, serotype-specific compartmental model...
September 3, 2016: Vaccine
Haogao Gu, Ross Ka-Kit Leung, Qinlong Jing, Wangjian Zhang, Zhicong Yang, Jiahai Lu, Yuantao Hao, Dingmei Zhang
Dengue fever (DF) is endemic in Guangzhou and has been circulating for decades, causing significant economic loss. DF prevention mainly relies on mosquito control and change in lifestyle. However, alert fatigue may partially limit the success of these countermeasures. This study investigated the delayed effect of meteorological factors, as well as the relationships between five climatic variables and the risk for DF by boosted regression trees (BRT) over the period of 2005-2011, to determine the best timing and strategy for adapting such preventive measures...
2016: International Journal of Environmental Research and Public Health
Bertsy Goic, Kenneth A Stapleford, Lionel Frangeul, Aurélien J Doucet, Valérie Gausson, Hervé Blanc, Nidia Schemmel-Jofre, Gael Cristofari, Louis Lambrechts, Marco Vignuzzi, Maria-Carla Saleh
Mosquitoes develop long-lasting viral infections without substantial deleterious effects, despite high viral loads. This makes mosquitoes efficient vectors for emerging viral diseases with enormous burden on public health. How mosquitoes resist and/or tolerate these viruses is poorly understood. Here we show that two species of Aedes mosquitoes infected with two arboviruses from distinct families (dengue or chikungunya) generate a viral-derived DNA (vDNA) that is essential for mosquito survival and viral tolerance...
2016: Nature Communications
Lysien I Zambrano, Manuel Sierra, Bredy Lara, Iván Rodríguez-Núñez, Marco T Medina, Carlos O Lozada-Riascos, Alfonso J Rodríguez-Morales
Geographical information systems (GIS) use for development of epidemiological maps in dengue has been extensively used, however not in other emerging arboviral diseases, nor in Central America. Surveillance cases data (2015) were used to estimate annual incidence rates of dengue and chikungunya (cases/100,000 pop) to develop the first maps in the departments and municipalities of Honduras. The GIS software used was Kosmo Desktop 3.0RC1(®). Four thematic maps were developed according departments, municipalities, diseases incidence rates...
August 22, 2016: Journal of Infection and Public Health
Jayashamani Tamibmaniam, Narwani Hussin, Wee Kooi Cheah, Kee Sing Ng, Prema Muninathan
BACKGROUND: WHO's new classification in 2009: dengue with or without warning signs and severe dengue, has necessitated large numbers of admissions to hospitals of dengue patients which in turn has been imposing a huge economical and physical burden on many hospitals around the globe, particularly South East Asia and Malaysia where the disease has seen a rapid surge in numbers in recent years. Lack of a simple tool to differentiate mild from life threatening infection has led to unnecessary hospitalization of dengue patients...
2016: PloS One
Gianne Eduard L Ulanday, Kenta Okamoto, Kouichi Morita
BACKGROUND: Dengue disease is one of the most significant vector-borne illnesses in the world. The emergence and re-emergence of dengue infections in many parts of the world affect millions annually and continue to burden public health systems especially in low-income populations. Advances in dengue vaccine development showed promising results; however, protection seems to be suboptimal. There is no licensed chemotherapeutic agent against dengue to date. An ideal scenario of combinatorial vaccination of high-risk individuals and chemotherapy of the diseased during outbreaks may compensate for the meager protection offered by the vaccine...
2016: Tropical Medicine and Health
Cheng Hoon Chew, Yuan Liang Woon, Faridah Amin, Tassha H Adnan, Asmah Hani Abdul Wahab, Zul Edzhar Ahmad, Mohd Adam Bujang, Abdul Muneer Abdul Hamid, Rahman Jamal, Wei Seng Chen, Chee Peng Hor, Lena Yeap, Ling Ping Hoo, Pik Pin Goh, Teck Onn Lim
BACKGROUND: Each year an estimated 390 million dengue infections occur worldwide. In Malaysia, dengue is a growing public health concern but estimate of its disease burden remains uncertain. We compared the urban-rural difference of dengue seroprevalence and determined age-specific dengue seroprevalence in Malaysia. METHODS: We undertook analysis on 11,821 subjects from six seroprevalence surveys conducted in Malaysia between 2001 and 2013, which composed of five urban and two rural series...
2016: BMC Public Health
Maria G Guzman, Duane J Gubler, Alienys Izquierdo, Eric Martinez, Scott B Halstead
Dengue is widespread throughout the tropics and local spatial variation in dengue virus transmission is strongly influenced by rainfall, temperature, urbanization and distribution of the principal mosquito vector Aedes aegypti. Currently, endemic dengue virus transmission is reported in the Eastern Mediterranean, American, South-East Asian, Western Pacific and African regions, whereas sporadic local transmission has been reported in Europe and the United States as the result of virus introduction to areas where Ae...
2016: Nature Reviews. Disease Primers
Joshua Nealon, Anne-Frieda Taurel, Maria Rosario Capeding, Ngoc Huu Tran, Sri Rezeki Hadinegoro, Tawee Chotpitayasunondh, Chee Kheong Chong, T Anh Wartel, Sophie Beucher, Carina Frago, Annick Moureau, Mark Simmerman, Thelma Laot, Maïna L'Azou, Alain Bouckenooghe
Dengue incidence has increased globally, but empirical burden estimates are scarce. Prospective methods are best-able to capture all severities of disease. CYD14 was an observer-blinded dengue vaccine study conducted in children 2-14 years of age in Indonesia, Malaysia, Thailand, the Philippines, and Vietnam. The control group received no vaccine and resembled a prospective, observational study. We calculated the rates of dengue according to different laboratory or clinical criteria to make inferences about dengue burden, and compared with rates reported in the passive surveillance systems to calculate expansion factors which describe under-reporting...
August 2016: PLoS Neglected Tropical Diseases
Niyati Khetarpal, Ira Khanna
Dengue is a highly endemic infectious disease of the tropical countries and is rapidly becoming a global burden. It is caused by any of the 4 serotypes of dengue virus and is transmitted within humans through female Aedes mosquitoes. Dengue disease varies from mild fever to severe conditions of dengue hemorrhagic fever and shock syndrome. Globalization, increased air travel, and unplanned urbanization have led to increase in the rate of infection and helped dengue to expand its geographic and demographic distribution...
2016: Journal of Immunology Research
Nowrozy Kamar Jahan, Mohtar Pungut Ahmad, Amreeta Dhanoa, Cheong Yuet Meng, Lau Wee Ming, Daniel D Reidpath, Pascale Allotey, Anuar Zaini, Maude Elvira Phipps, Quek Kia Fatt, Aman Bin Rabu, Rowther Sirajudeen, Ahmad AbdulBasitz Ahmad Fatan, Faidzal Adlee Ghafar, Hamdan Bin Ahmad, Iekhsan Othman, Sharifah SyedHassan
BACKGROUND: Globally, dengue infections constitute a significant public health burden. In recent decades, Malaysia has become a dengue hyper-endemic country with the co-circulation of the four dengue virus serotypes. The cyclical dominance of sub-types contributes to a pattern of major outbreaks. The consequences can be observed in the rising incidence of reported dengue cases and dengue related deaths. Understanding the complex interaction of the dengue virus, its human hosts and the mosquito vectors at the community level may help develop strategies for addressing the problem...
2016: Infectious Diseases of Poverty
Lesley J Scott
Tetravalent, live-attenuated, dengue vaccine (Dengvaxia(®); CYD-TDV) is the first vaccine approved for the prevention of dengue disease caused by dengue virus (DENV) serotypes 1-4 in individuals aged 9-45 or 9-60 years living in high dengue endemic areas. This narrative review discusses the immunogenicity, protective efficacy, reactogenicity and safety of CYD-TDV in the prevention of dengue disease. In Latin American and Asian phase 3 trials in children and adolescents (n > 30,000), the recommended three-dose CYD-TDV regimen was efficacious in preventing virologically-confirmed dengue (VCD) during the period from 28 days after the last dose (month 13) to month 25, meeting the primary endpoint criteria...
September 2016: Drugs
Jui-Hung Kao, Chaur-Dong Chen, Zheng-Rong Tiger Li, Ta-Chien Chan, Tsung-Hwa Tung, Yin-Hsia Chu, Hau-Yuan Cheng, Jien-Wei Liu, Fuh-Yuan Shih, Pei-Yun Shu, Chien-Chou Lin, Wu-Hsiung Tsai, Chia-Chi Ku, Chi-Kung Ho, Chwan-Chuen King
The increasing dengue burden and epidemic severity worldwide have highlighted the need to improve surveillance. In non-endemic areas such as Taiwan, where outbreaks start mostly with imported cases from Southeast Asia, a closer examination of surveillance dynamics to detect cases early is necessary. To evaluate problems with dengue surveillance and investigate the involvement of different factors at various epidemic stages, we investigated 632 laboratory-confirmed indigenous dengue cases in Kaohsiung City, Taiwan during 2009-2010...
2016: PloS One
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