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https://www.readbyqxmd.com/read/29188134/assessing-the-prevalence-of-risk-factors-for-neglected-tropical-diseases-in-brazos-county-texas
#1
Jennifer Horney, Daniel Goldberg, Tracy Hammond, Kahler Stone, Seth Smitherman
Introduction: Although more than one billion people live at risk of neglected tropical diseases (NTDs) in areas of Asia, sub-Saharan Africa, and Latin America, the degree to which they burden countries like the U.S. is unclear. Even though many NTDs such as dengue, leishmaniasis, and Chagas disease are typically not endemic to the U.S., the possibility of their emergence is noteworthy, especially in states like Texas with high levels of poverty, large immigrant populations, geographic proximity to endemic areas, and a climate amenable to the vectors for these diseases...
October 4, 2017: PLoS Currents
https://www.readbyqxmd.com/read/29183717/using-wolbachia-for-dengue-control-insights-from-modelling
#2
REVIEW
Ilaria Dorigatti, Clare McCormack, Gemma Nedjati-Gilani, Neil M Ferguson
Dengue is the most common arboviral infection of humans, responsible for a substantial disease burden across the tropics. Traditional insecticide-based vector-control programmes have limited effectiveness, and the one licensed vaccine has a complex and imperfect efficacy profile. Strains of the bacterium Wolbachia, deliberately introduced into Aedes aegyptimosquitoes, have been shown to be able to spread to high frequencies in mosquito populations in release trials, and mosquitoes infected with these strains show markedly reduced vector competence...
November 25, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/29145452/behavioral-climatic-and-environmental-risk-factors-for-zika-and-chikungunya-virus-infections-in-rio-de-janeiro-brazil-2015-16
#3
Trevon L Fuller, Guilherme Calvet, Camila Genaro Estevam, Jussara Rafael Angelo, Gbenga J Abiodun, Umme-Aiman Halai, Bianca De Santis, Patricia Carvalho Sequeira, Eliane Machado Araujo, Simone Alves Sampaio, Marco Cesar Lima de Mendonça, Allison Fabri, Rita Maria Ribeiro, Ryan Harrigan, Thomas B Smith, Claudia Raja Gabaglia, Patrícia Brasil, Ana Maria Bispo de Filippis, Karin Nielsen-Saines
The burden of arboviruses in the Americas is high and may result in long-term sequelae with infants disabled by Zika virus infection (ZIKV) and arthritis caused by infection with Chikungunya virus (CHIKV). We aimed to identify environmental drivers of arbovirus epidemics to predict where the next epidemics will occur and prioritize municipalities for vector control and eventual vaccination. We screened sera and urine samples (n = 10,459) from residents of 48 municipalities in the state of Rio de Janeiro for CHIKV, dengue virus (DENV), and ZIKV by molecular PCR diagnostics...
2017: PloS One
https://www.readbyqxmd.com/read/29138300/high-zika-virus-seroprevalence-in-salvador-northeastern-brazil-limits-the-potential-for-further-outbreaks
#4
Eduardo Martins Netto, Andres Moreira-Soto, Celia Pedroso, Christoph Höser, Sebastian Funk, Adam J Kucharski, Alexandra Rockstroh, Beate M Kümmerer, Gilmara Souza Sampaio, Estela Luz, Sara Nunes Vaz, Juarez Pereira Dias, Fernanda Anjos Bastos, Renata Cabral, Thomas Kistemann, Sebastian Ulbert, Xavier de Lamballerie, Thomas Jaenisch, Oliver J Brady, Christian Drosten, Manoel Sarno, Carlos Brites, Jan Felix Drexler
During 2015 to 2016, Brazil reported more Zika virus (ZIKV) cases than any other country, yet population exposure remains unknown. Serological studies of ZIKV are hampered by cross-reactive immune responses against heterologous viruses. We conducted serosurveys for ZIKV, dengue virus (DENV), and Chikungunya virus (CHIKV) in 633 individuals prospectively sampled during 2015 to 2016, including microcephaly and non-microcephaly pregnancies, HIV-infected patients, tuberculosis patients, and university staff in Salvador in northeastern Brazil using enzyme-linked immunosorbent assays (ELISAs) and plaque reduction neutralization tests...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29137663/patent-landscape-of-neglected-tropical-diseases-an-analysis-of-worldwide-patent-families
#5
Folahanmi Tomiwa Akinsolu, Vitor Nobre de Paiva, Samuel Santos Souza, Orsolya Varga
BACKGROUND: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. However, it is crucial to intensify research effort into NTDs, because of the emerging drug resistance. According to the World Health Organization (WHO), the term NTDs covers 17 diseases, namely buruli ulcer, Chagas disease, dengue, dracunculiasis, echinococcosis, trematodiasis, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthes, taeniasis, trachoma, and yaws...
November 14, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29118655/the-burden-of-dengue-source-reduction-measures-and-serotype-patterns-in-myanmar-2011-to-2015-r2
#6
Pwint Mon Oo, Khin Thet Wai, Anthony D Harries, Hemant Deepak Shewade, Tin Oo, Aung Thi, Zaw Lin
Background: Myanmar is currently classified as a high burden dengue country in the Asian Pacific region. The Myanmar vector-borne diseases control (VBDC) program has collected data on dengue and source reduction measures since 1970, and there is a pressing need to collate, analyze, and interpret this information. The aim of this study was to describe the burden of hospital-based dengue disease, dengue control measures, and serotype patterns in Myanmar between 2011 and 2015. Methods: This was a cross-sectional study using annual records from the Dengue Fever/Dengue Hemorrhagic Fever Prevention and Control Project in Myanmar...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29117180/the-additional-benefit-of-residual-spraying-and-insecticide-treated-curtains-for-dengue-control-over-current-best-practice-in-cuba-evaluation-of-disease-incidence-in-a-cluster-randomized-trial-in-a-low-burden-setting-with-intensive-routine-control
#7
Maria Eugenia Toledo, Veerle Vanlerberghe, Julio Popa Rosales, Mayelin Mirabal, Pedro Cabrera, Viviana Fonseca, Tania Gómez Padrón, Mirtha Pérez Menzies, Domingo Montada, Patrick Van der Stuyft
BACKGROUND: Aedes control interventions are considered the cornerstone of dengue control programmes, but there is scarce evidence on their effect on disease. We set-up a cluster randomized controlled trial in Santiago de Cuba to evaluate the entomological and epidemiological effectiveness of periodical intra- and peri-domiciliary residual insecticide (deltamethrin) treatment (RIT) and long lasting insecticide treated curtains (ITC). METHODOLOGY/PRINCIPAL FINDINGS: Sixty three clusters (around 250 households each) were randomly allocated to two intervention (RIT and ITC) and one control arm...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29103928/surveillance-of-intensity-level-and-geographical-spreading-of-dengue-outbreak-among-males-and-females-in-punjab-pakistan-a-case-study-of-2011
#8
Shahbaz Ahmad, Muhammad Asif, Ramzan Talib, Muhammad Adeel, Muhammad Yasir, Muhammad Hasanain Chaudary
BACKGROUND: Dengue fever is viral disease which spreads due to the bite of the Aedes aegypti mosquito. In recent years, it has affected around 40% population of the world. Its endemic flow has led to a large disease burden, in terms of human and financial resources. METHODS: Geographical Information Systems (GIS) are normally used to develop epidemiological thematic maps. This study explores the patterns and hotspots, associated with the catastrophic outbreak of dengue, in Punjab, in 2011...
November 2, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29091713/after-the-epidemic-zika-virus-projections-for-latin-america-and-the-caribbean
#9
Felipe J Colón-González, Carlos A Peres, Christine Steiner São Bernardo, Paul R Hunter, Iain R Lake
BACKGROUND: Zika is one of the most challenging emergent vector-borne diseases, yet its future public health impact remains unclear. Zika was of little public health concern until recent reports of its association with congenital syndromes. By 3 August 2017 ∼217,000 Zika cases and ∼3,400 cases of associated congenital syndrome were reported in Latin America and the Caribbean. Some modelling exercises suggest that Zika virus infection could become endemic in agreement with recent declarations from the The World Health Organisation...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29091011/clinical-proteomics-and-cytokine-profiling-for-dengue-fever-disease-severity-biomarkers
#10
Manali Jadhav, Monalisha Nayak, Swati Kumar, Apoorva Venkatesh, Sandip K Patel, Vipin Kumar, Sarthak Sharma, Biaus Samanta, Satarupa Deb, Avik Karak, Sumit Verma, Arunansu Talukdar, Sanjay K Kochar, Preeti Mansukhani, Mayuri Gandhi, Sanjeeva Srivastava
Dengue fever (DF) is a major global health burden with a pathophysiology that is still incompletely understood. Biomarkers that predict and explain susceptibility to DF and its progression to its more severe hemorrhagic form are much needed. DF is endemic in tropical and subtropical regions of the world, with a rapidly increasing incidence of disease severity. We conducted a clinical biomarker discovery study using both a case-control and longitudinal study design. Plasma proteome alterations in patients with DF (n = 12) and dengue hemorrhagic fever (DHF, n = 24) were analyzed in comparison to healthy controls (HCs, n = 16), using the isobaric tags for relative and absolute quantification (iTRAQ)-based quantitative proteomics methodology (false discovery rate of 1%, ≥2 peptides)...
November 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29084220/a-multi-country-study-of-the-economic-burden-of-dengue-fever-vietnam-thailand-and-colombia
#11
Jung-Seok Lee, Vittal Mogasale, Jacqueline K Lim, Mabel Carabali, Kang-Sung Lee, Chukiat Sirivichayakul, Duc Anh Dang, Diana Cristina Palencia-Florez, Thi Hien Anh Nguyen, Arthorn Riewpaiboon, Pornthep Chanthavanich, Luis Villar, Brian A Maskery, Andrew Farlow
BACKGROUND: Dengue fever is a major public health concern in many parts of the tropics and subtropics. The first dengue vaccine has already been licensed in six countries. Given the growing interests in the effective use of the vaccine, it is critical to understand the economic burden of dengue fever to guide decision-makers in setting health policy priorities. METHODS/PRINCIPAL FINDINGS: A standardized cost-of-illness study was conducted in three dengue endemic countries: Vietnam, Thailand, and Colombia...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29075656/rearing-of-culex-spp-and-aedes-spp-mosquitoes
#12
Elizabeth Kauffman, Anne Payne, Mary A Franke, Michael A Schmid, Eva Harris, Laura D Kramer
Mosquito-transmitted pathogens cause major public health problems and contribute substantially to the global burden of disease. Aedes mosquitoes transmit dengue, Zika, yellow fever, and Chikungunya viruses; Culex mosquitoes transmit West Nile, Japanese encephalitis, and Saint Louis encephalitis viruses, among others. Experiments utilizing laboratory-reared colonized mosquitoes can address many issues such as vector biology, vector competence, vector-pathogen interaction, and vector control. The establishment of healthy and standardized mosquito colonies requires generation and implementation of protocols, attention to detail, and an understanding of the factors that affect mosquito fitness, such as temperature and humidity, nutrient quality and availability, population density, blood feeding and mating behavior, and egg-laying requirements...
September 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/29051080/antiviral-activity-of-n-4-hydroxyphenyl-retinamide-4-hpr-against-zika-virus
#13
Jared D Pitts, Pi-Chun Li, Melissanne de Wispelaere, Priscilla L Yang
The rapid spread of Zika virus (ZIKV) in recent years has highlighted the severe diseases associated with ZIKV infection, such as Guillain-Barré syndrome in adults and microcephaly in newborns; yet no vaccines or antivirals currently exist to prevent or treat ZIKV infection. We and others have previously identified N-(4-hydroxyphenyl) retinamide (fenretinide or 4-HPR) as an antiviral compound that inhibits dengue virus 2 (DV2) and other flaviviruses by limiting the steady-state accumulation of viral RNA. Here we show that 4-HPR potently inhibits ZIKV in mammalian cell culture and significantly reduces both serum viremia and brain viral burden in a murine model of ZIKV infection...
November 2017: Antiviral Research
https://www.readbyqxmd.com/read/29045735/seasonal-variation-and-dengue-burden-in-paediatric-patients-in-new-delhi
#14
Manas Pratim Roy, Ratan Gupta, Nidhi Chopra, Satish Kumar Meena, Kailash Chander Aggarwal
Objective: We conducted a study to find a relationship between main weather parameters with admission of positive dengue cases in a tertiary hospital. Methods: Retrospective analysis was undertaken to identify epidemiological trend of dengue in 2016 from paediatric wards of a tertiary hospital in New Delhi. Data were collected on patient particulars and daily weather from January to December 2016. Results: A total of 266 confirmed cases of dengue were considered...
October 17, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29045406/microrna-profiling-of-human-primary-macrophages-exposed-to-dengue-virus-identifies-mirna-3614-5p-as-antiviral-and-regulator-of-adar1-expression
#15
Mayra Diosa-Toro, Liliana Echavarría-Consuegra, Jacky Flipse, Geysson Javier Fernández, Joost Kluiver, Anke van den Berg, Silvio Urcuqui-Inchima, Jolanda M Smit
BACKGROUND: Due to the high burden of dengue disease worldwide, a better understanding of the interactions between dengue virus (DENV) and its human host cells is of the utmost importance. Although microRNAs modulate the outcome of several viral infections, their contribution to DENV replication is poorly understood. METHODS AND PRINCIPAL FINDINGS: We investigated the microRNA expression profile of primary human macrophages challenged with DENV and deciphered the contribution of microRNAs to infection...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29031286/surveillance-of-vector-borne-infections-chikungunya-dengue-and-malaria-in-bo-sierra-leone-2012-2013
#16
Donald F Dariano, Chris R Taitt, Kathryn H Jacobsen, Umaru Bangura, Alfred S Bockarie, Moses J Bockarie, Joseph Lahai, Joseph M Lamin, Tomasz A Leski, Chadwick Yasuda, David A Stenger, Rashid Ansumana
Malaria remains a significant cause of morbidity and mortality in West Africa, but the contribution of other vector-borne infections (VBIs) to the burden of disease has been understudied. We used rapid diagnostic tests (RDTs) for three VBIs to test blood samples from 1,795 febrile residents of Bo City, Sierra Leone, over a 1-year period in 2012-2013. In total, 24% of the tests were positive for malaria, fewer than 5% were positive for markers of dengue virus infection, and 39% were positive for IgM directed against chikungunya virus (CHIKV) or a related alphavirus...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28993172/hidden-burden-of-chikungunya-in-north-india-a-prospective-study-in-a-tertiary-care-centre
#17
Anju Dinkar, Jitendra Singh, Pradyot Prakash, Arghya Das, Gopal Nath
BACKGROUND: Arboviral diseases, such as chikungunya, dengue and now zika represent a public health problem, especially in tropical countries. Epidemiology of chikungunya and dengue is well known, including its social and climatic factors associated, but only few data and reports of chikungunya are available from North India. The clinical differentiation of chikungunya from dengue is no doubt challenging since both diseases can share clinical signs and symptoms leading to potential misdiagnosis of chikungunya in areas where dengue is endemic...
October 6, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28977169/dengue-in-pregnant-women-characterization-of-cases-in-brazil-2007-2015
#18
Laura Branquinho do Nascimento, Cláudio Morais Siqueira, Giovanini Evelim Coelho, João Bosco Siqueira
OBJECTIVE: to characterize the probable cases of dengue in pregnant women reported in Brazil, from 2007 to 2015. METHODS: descriptive study of sociodemographic, epidemiological, clinical and laboratory characteristics, with data from the Information System for Notifiable Diseases (Sinan). RESULTS: the annual incidence of dengue in pregnant women ranged from 3.3 (2009) to 816.6 (2010) cases per 100 thousand live births; of the 43,772 probable cases of dengue in pregnant women, 81...
July 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28953902/immune-status-alters-the-probability-of-apparent-illness-due-to-dengue-virus-infection-evidence-from-a-pooled-analysis-across-multiple-cohort-and-cluster-studies
#19
Hannah E Clapham, Derek A T Cummings, Michael A Johansson
Dengue is an important vector-borne pathogen found across much of the world. Many factors complicate our understanding of the relationship between infection with one of the four dengue virus serotypes, and the observed incidence of disease. One of the factors is a large proportion of infections appear to result in no or few symptoms, while others result in severe infections. Estimates of the proportion of infections that result in no symptoms (inapparent) vary widely from 8% to 100%, depending on study and setting...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28949904/a-lethal-model-of-disseminated-dengue-virus-type-1-infection-in-ag129-mice
#20
Gregg N Milligan, Vanessa V Sarathy, Mellodee M White, M Banks Greenberg, Gerald A Campbell, Richard B Pyles, Alan D T Barrett, Nigel Bourne
The mosquito-borne disease dengue is caused by four serologically and genetically related flaviviruses termed DENV-1 to DENV-4. Dengue is a global public health concern, with both the geographical range and burden of disease increasing rapidly. Clinically, dengue ranges from a relatively mild self-limiting illness to a severe life-threatening and sometimes fatal disease. Infection with one DENV serotype produces life-long homotypic immunity, but incomplete and short-term heterotypic protection. The development of small-animal models that recapitulate the characteristics of the disseminated disease seen clinically has been difficult, slowing the development of vaccines and therapeutics...
October 2017: Journal of General Virology
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