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https://www.readbyqxmd.com/read/27909576/zika-antiviral-chemotherapy-identification-of-drugs-and-promising-starting-points-for-drug-discovery-from-an-fda-approved-library
#1
Bruno S Pascoalino, Gilles Courtemanche, Marli T Cordeiro, Laura H V G Gil, Lucio Freitas-Junior
Background The recent epidemics of Zika virus (ZIKV) implicated it as the cause of serious and potentially lethal congenital conditions such microcephaly and other central nervous system defects, as well as the development of the Guillain-Barré syndrome in otherwise healthy patients. Recent findings showed that anti-Dengue antibodies are capable of amplifying ZIKV infection by a mechanism similar to antibody-dependent enhancement, increasing the severity of the disease. This scenario becomes potentially catastrophic when the global burden of Dengue and the advent of the newly approved anti-Dengue vaccines in the near future are taken into account...
2016: F1000Research
https://www.readbyqxmd.com/read/27898668/the-long-term-safety-public-health-impact-and-cost-effectiveness-of-routine-vaccination-with-a-recombinant-live-attenuated-dengue-vaccine-dengvaxia-a-model-comparison-study
#2
Stefan Flasche, Mark Jit, Isabel Rodríguez-Barraquer, Laurent Coudeville, Mario Recker, Katia Koelle, George Milne, Thomas J Hladish, T Alex Perkins, Derek A T Cummings, Ilaria Dorigatti, Daniel J Laydon, Guido España, Joel Kelso, Ira Longini, Jose Lourenco, Carl A B Pearson, Robert C Reiner, Luis Mier-Y-Terán-Romero, Kirsten Vannice, Neil Ferguson
BACKGROUND: Large Phase III trials across Asia and Latin America have recently demonstrated the efficacy of a recombinant, live-attenuated dengue vaccine (Dengvaxia) over the first 25 mo following vaccination. Subsequent data collected in the longer-term follow-up phase, however, have raised concerns about a potential increase in hospitalization risk of subsequent dengue infections, in particular among young, dengue-naïve vaccinees. We here report predictions from eight independent modelling groups on the long-term safety, public health impact, and cost-effectiveness of routine vaccination with Dengvaxia in a range of transmission settings, as characterised by seroprevalence levels among 9-y-olds (SP9)...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27897196/product-release-is-rate-limiting-for-catalytic-processing-by-the-dengue-virus-protease
#3
A E Shannon, M M Pedroso, K J Chappell, D Watterson, S Liebscher, W M Kok, D P Fairlie, G Schenk, P R Young
Dengue Virus (DENV) is the most prevalent global arbovirus, yet despite an increasing burden to health care there are currently no therapeutics available to treat infection. A potential target for antiviral drugs is the two-component viral protease NS2B-NS3pro, which is essential for viral replication. Interactions between the two components have been investigated here by probing the effect on the rate of enzyme catalysis of key mutations in a mobile loop within NS2B that is located at the interface of the two components...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27883970/association-between-dengue-fever-incidence-and-meteorological-factors-in-guangzhou-china-2005-2014
#4
Jianjun Xiang, Alana Hansen, Qiyong Liu, Xiaobo Liu, Michael Xiaoliang Tong, Yehuan Sun, Scott Cameron, Scott Hanson-Easey, Gil-Soo Han, Craig Williams, Philip Weinstein, Peng Bi
This study aims to (1) investigate the associations between climatic factors and dengue; and (2) identify the susceptible subgroups. De-identified daily dengue cases in Guangzhou for 2005-2014 were obtained from the Chinese Center for Disease Control and Prevention. Weather data were downloaded from the China Meteorological Data Sharing Service System. Distributed lag non-linear models (DLNM) were used to graphically demonstrate the three-dimensional temperature-dengue association. Generalised estimating equation models (GEE) with piecewise linear spline functions were used to quantify the temperature-dengue associations...
November 22, 2016: Environmental Research
https://www.readbyqxmd.com/read/27879463/a-tale-of-two-flaviviruses-a-seroepidemiological-study-of-dengue-virus-and-west-nile-virus-transmission-in-the-ouest-and-sud-est-departments-of-haiti
#5
Thomas A Weppelmann, Alexandra Burne, Michael E von Fricken, Maha A Elbadry, Madsen Beau De Rochars, Jacques Boncy, Bernard A Okech
Though plans to eliminate malaria from the island of Hispaniola have recently received much attention, arbovirus surveillance continues to be largely neglected in Haiti. To support surveillance efforts and encourage vector-control strategies, a cross-sectional study of dengue virus (DENV) and West Nile virus (WNV) transmission was conducted using standard seroepidemiological methods. Blood samples (N = 673) were collected from 278 males and 395 females from three locations in the Ouest and Sud-Est Departments of Haiti...
November 22, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27869724/mosquito-oviposition-behavior-and-vector-control
#6
REVIEW
Jonathan F Day
The burden of gene transfer from one mosquito generation to the next falls on the female and her eggs. The selection of an oviposition site that guarantees egg and larval survival is a critical step in the reproductive process. The dangers associated with ephemeral aquatic habitats, lengthy droughts, freezing winters, and the absence of larval nutrition makes careful oviposition site selection by a female mosquito extremely important. Mosquito species exhibit a remarkable diversity of oviposition behaviors that ensure eggs are deposited into microenvironments conducive for successful larval development and the emergence of the next mosquito generation...
November 18, 2016: Insects
https://www.readbyqxmd.com/read/27843790/trends-in-clinical-trials-of-dengue-vaccine
#7
REVIEW
Priya Marimuthu, Jamuna Rani Ravinder
Dengue is one of the most important vector-borne disease and an increasing problem worldwide because of current globalization trends. Roughly, half the world's population lives in dengue endemic countries, and nearly 100 million people are infected annually with dengue. India has the highest burden of the disease with 34% of the global cases. In the context of an expanding and potentially fatal infectious disease without effective prevention or specific treatment, the public health value of a protective vaccine is clear...
October 2016: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/27827943/a-spatial-hierarchical-analysis-of-the-temporal-influences-of-the-el-ni%C3%A3-o-southern-oscillation-and-weather-on-dengue-in-kalutara-district-sri-lanka
#8
Prasad Liyanage, Hasitha Tissera, Maquins Sewe, Mikkel Quam, Ananda Amarasinghe, Paba Palihawadana, Annelies Wilder-Smith, Valérie R Louis, Yesim Tozan, Joacim Rocklöv
Dengue is the major public health burden in Sri Lanka. Kalutara is one of the highly affected districts. Understanding the drivers of dengue is vital in controlling and preventing the disease spread. This study focuses on quantifying the influence of weather variability on dengue incidence over 10 Medical Officer of Health (MOH) divisions of Kalutara district. Weekly weather variables and data on dengue notifications, measured at 10 MOH divisions in Kalutara from 2009 to 2013, were retrieved and analysed. Distributed lag non-linear model and hierarchical-analysis was used to estimate division specific and overall relationships between weather and dengue...
November 4, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27827425/downregulation-of-aedes-aegypti-chromodomain-helicase-dna-binding-protein-7-kismet-by-wolbachia-and-its-effect-on-dengue-virus-replication
#9
Sultan Asad, Sonja Hall-Mendelin, Sassan Asgari
Dengue virus (DENV) is a mosquito-transmitted virus imposing a significant burden on human health around the world. Since current control strategies are not sufficient, there is an urgent need to find alternative methods to control DENV transmission. It has been demonstrated that introduction of Wolbachia pipientis in Aedes aegypti mosquitoes can impede DENV transmission with the mechanism(s) not fully understood. Recently, a number of studies have found the involvement of chromodomain DNA binding helicases in case of Human Immunodeficiency virus (HIV) and Influenza A virus infection...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27825949/dengue-serotype-specific-seroprevalence-among-5-to-10-year-old-children-in-india-a-community-based-cross-sectional-study
#10
Suneela Garg, Anita Chakravarti, Ritesh Singh, N R Ramesh Masthi, Ram Chandra Goyal, Guru Rajesh Jammy, Enakshi Ganguly, Nandini Sharma, M M Singh, Germano Ferreira, Annick Moureau, Sujeet Ojha, Joshua Nealon
BACKGROUND: Dengue surveillance data in India are limited and probably substantially underestimate the burden of disease. A community-based study was undertaken to assess the prevalence of dengue-specific immunoglobulin G (IgG) antibodies in children across India and to examine historical dengue exposure rates. Potential associations between socio-economic factors and dengue seroprevalence were also assessed (registered at ctri.nic.in: CTRI/2011/12/002243). METHODS: A convenience sample of 2609 healthy children aged 5-10 years was enrolled; these children were registered at or were living in the vicinity of eight centres located at six geographically distinct sites across India...
November 4, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27825383/dengue-research-networks-building-evidence-for-policy-and-planning-in-brazil
#11
Bruna de Paula Fonseca E Fonseca, Fabio Zicker
BACKGROUND: The analysis of scientific networks has been applied in health research to map and measure relationships between researchers and institutions, describing collaboration structures, individual roles, and research outputs, and helping the identification of knowledge gaps and cooperation opportunities. Driven by dengue continued expansion in Brazil, we explore the contribution, dynamics and consolidation of dengue scientific networks that could ultimately inform the prioritisation of research, financial investments and health policy...
November 8, 2016: Health Research Policy and Systems
https://www.readbyqxmd.com/read/27820821/a-cluster-randomized-controlled-trial-to-reduce-diarrheal-disease-and-dengue-entomological-risk-factors-in-rural-primary-schools-in-colombia
#12
Hans J Overgaard, Neal Alexander, Maria Ines Matiz, Juan Felipe Jaramillo, Victor Alberto Olano, Sandra Vargas, Diana Sarmiento, Audrey Lenhart, Thor Axel Stenström
BACKGROUND: As many neglected tropical diseases are co-endemic and have common risk factors, integrated control can efficiently reduce disease burden and relieve resource-strained public health budgets. Diarrheal diseases and dengue fever are major global health problems sharing common risk factors in water storage containers. Where provision of clean water is inadequate, water storage is crucial. Fecal contamination of stored water is a common source of diarrheal illness, but stored water also provides breeding sites for dengue vector mosquitoes...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27814732/detection-of-dengue-virus-serotypes-1-2-and-3-in-selected-regions-of-kenya-2011-2014
#13
Limbaso Konongoi, Victor Ofula, Albert Nyunja, Samuel Owaka, Hellen Koka, Albina Makio, Edith Koskei, Fredrick Eyase, Daniel Langat, Randal J Schoepp, Cynthia Ann Rossi, Ian Njeru, Rodney Coldren, Rosemary Sang
BACKGROUND: Dengue fever, a mosquito-borne disease, is associated with illness of varying severity in countries in the tropics and sub tropics. Dengue cases continue to be detected more frequently and its geographic range continues to expand. We report the largest documented laboratory confirmed circulation of dengue virus in parts of Kenya since 1982. METHODS: From September 2011 to December 2014, 868 samples from febrile patients were received from hospitals in Nairobi, northern and coastal Kenya...
November 4, 2016: Virology Journal
https://www.readbyqxmd.com/read/27812857/epidemiological-and-etiological-investigation-of-dengue-fever-in-the-fujian-province-of-china-during-2004-2014
#14
Jinzhang Wang, Hongbing Chen, Meng Huang, Yongjun Zhang, Jianfeng Xie, Yansheng Yan, Kuicheng Zheng, Yuwei Weng
Dengue fever (DF) is a vector-borne disease and a tremendous socioeconomic burden on tropical and subtropical countries worldwide. To explore the characteristics of DF epidemic in the Fujian province, information of DF cases in Fujian during 2004-2014 was collected and analyzed. The complete E genes of 48 viral isolates were amplified and sequenced for phylogenetic analysis. A total of 733 cases was reported, of which 612 (83.5%) occurred during the peak period from August to October. Additionally, 76% (190/250) of imported cases originated from Southeast Asia countries, by the epidemiological investigation...
October 31, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27786589/current-management-of-severe-dengue-infection
#15
Tau Hong Lee, Linda Kay Lee, David Chien Lye, Yee Sin Leo
Traditionally a disease mainly affecting the pediatric population, dengue burden has increased significantly in recent decades and adults with severe disease may become more common. There is currently no effective anti-viral agent available for the treatment of dengue and supportive care is the mainstay of management. Areas covered: We present a review of current literature on dengue severity classification systems and the management of severe dengue in adults. In particular, emphasis was placed on organ impairment in dengue and management of elderly individuals with multiple medical problems...
October 27, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27763483/the-mysterious-zika-virus-adding-to-the-tropical-flavivirus-mayhem
#16
B Mishra, B Behera
Until now, known as the demure cousin of dengue virus (DENV) inhabiting Africa, Zika virus (ZIKV) has reinvented itself to cause explosive epidemics captivating the Western hemisphere. The outbreak causing potential for ZIKV was realized when it made its way from Africa to Yap Island Micronesia in 2007, and in French Polynesia in 2013. From there, it moved on to Brazil in 2015. Now ZIKV has infected people in more than 33 countries in Central and South America and the Caribbean. Moreover the epidemiological and subsequent virological association with microcephaly cases in Brazil has prompted the World Health Organization to declare a public health emergency of International Concern...
October 2016: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/27739262/a-multi-centric-double-blind-placebo-controlled-randomized-prospective-study-to-evaluate-the-efficacy-and-safety-of-carica-papaya-leaf-extract-as-empirical-therapy-for-thrombocytopenia-associated-with-dengue-fever
#17
Prabhu Nagnathappa Kasture, K H Nagabhushan, Arun Kumar
INTRODUCTION: Dengue is a rapidly expanding global health problem. Approximately 2.5 billion people live in dengue-risk regions with about 100 million new cases each year worldwide. The cumulative dengue diseases burden has attained an unprecedented proportion in recent times with sharp increase in the size of human population at risk. The management of dengue virus infection is essentially supportive and symptomatic and no specific treatment is available for increasing the fallen platelets, which have a significant role in causing the mortality of dengue patient...
June 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27733281/global-regional-and-national-life-expectancy-all-cause-mortality-and-cause-specific-mortality-for-249-causes-of-death-1980-2015-a-systematic-analysis-for-the-global-burden-of-disease-study-2015
#18
COMMENT
(no author information available yet)
BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures. METHODS: We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010...
October 8, 2016: Lancet
https://www.readbyqxmd.com/read/27681542/wolbachia-a-biological-control-strategy-against-arboviral-diseases
#19
REVIEW
Ipsita Mohanty, Animesha Rath, Namita Mahapatra, Rupenangshu K Hazra
Vector-borne diseases particularly those transmitted by mosquitoes like Dengue are among the leading causes of mortality and morbidity in human population. There are no effective vaccines or treatment against dengue fever till date and the control methods are limited. So, new approaches are urgently in need to reverse these trends. Vector control is currently the primary intervention tool. Strategies that reduce or block pathogen transmission by mosquitoes have been proposed as a means of augmenting current control measures to reduce the growing burden of vector-borne diseases...
July 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/27663790/dengue-serotype-immune-interactions-and-their-consequences-for-vaccine-impact-predictions
#20
José Lourenço, Mario Recker
Dengue is one of the most important and wide-spread viral infections affecting human populations. The last few decades have seen a dramatic increase in the global burden of dengue, with the virus now being endemic or near-endemic in over 100 countries world-wide. A recombinant tetravalent vaccine candidate (CYD-TDV) has recently completed Phase III clinical efficacy trials in South East Asia and Latin America and has been licensed for use in several countries. The trial results showed moderate-to-high efficacies in protection against clinical symptoms and hospitalisation but with so far unknown effects on transmission and infections per se...
September 2016: Epidemics
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