keyword
MENU ▼
Read by QxMD icon Read
search

Interferon-alpha

keyword
https://www.readbyqxmd.com/read/29348488/interferon-alpha-enhances-the-antitumour-activity-of-egfr-targeted-therapies-by-upregulating-rig-i-in-head-and-neck-squamous-cell-carcinoma
#1
Hailong Ma, Shufang Jin, Wenyi Yang, Ge Zhou, Mei Zhao, Sijie Fang, Zhiyuan Zhang, Jingzhou Hu
BACKGROUND: The epidermal growth factor receptor (EGFR)-targeted therapies have been tested in the clinic as treatments for head and neck squamous cell carcinoma (HNSCC). Owing to intrinsic or acquired resistance, EGFR-targeted therapies often lead to a low response rate and treatment failure. Interferon-alpha (IFNα) is a chemosensitising agent and multi-functional cytokine with a tumour inhibitory effect. However, the synergic effect of IFNα and EGFR-targeted therapies (erlotinib and nimotuzumab) and their mechanisms in HNSCC remain unclear...
January 18, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29314573/higher-efficacy-of-pegylated-interferon-alpha-2b-add-on-therapy-in-hbeag-positive-chronic-hepatitis-b-patients-on-tenofovir-monotherapy
#2
Ankur Jindal, Ashish Kumar Vyas, Devesh Kumar, Guresh Kumar, Manoj Kumar Sharma, Shiv Kumar Sarin
BACKGROUND: Monotherapy with Peg-IFNα or nucleos(t)ide analogues(NA) currently approved for treating chronic hepatitis B(CHB) have limited efficacy. Studies on combination of Peg-IFN-α/NA have shown conflicting results. We investigated whether sequential adding-on Peg-IFNα to tenofovir enhances serological response rates. METHODS: Treatment naïve, HBeAg-positive CHB patients with moderately elevated ALT(48 to 200IU/mL) were started on tenofovir(300 mg/day) and enrolled at week 12 in 1:1 ratio to either receive Peg-IFNα2b add-on(1...
January 4, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29290077/efficacy-and-safety-of-interferon-alpha-for-essential-thrombocythemia-during-pregnancy-two-cases-and-a-literature-review
#3
Kazuya Sakai, Akane Ueda, Masaaki Hasegawa, Yasunori Ueda
For pregnant women with essential thrombocythemia (ET), no standard approach for managing the platelet count has been established. We present the cases of two pregnant women with ET treated with interferon (IFN)-alpha. Each case showed a marked platelet decrease, from values within normal limits at the time of delivery, with no severe adverse events. To clarify the efficacy and safely of IFN alpha for ET during pregnancy, we performed a literature review. A total of 43 pregnant women with ET were ultimately identified from 12 articles and the present cases...
December 30, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29289653/in-vitro-investigations-on-the-effects-of-semi-synthetic-sulphated-carbohydrates-on-the-immune-status-of-cultured-common-carp-cyprinus-carpio-leucocytes
#4
N Kareem, E Yates, M Skidmore, D Hoole
The rapid emergence of drug resistance, unfavourable immunosuppression and mounting evidence to suggest the deleterious accumulation of drug breakdown residues within animal tissues has driven a strong desire to move away from these current methods of disease control. Some natural products such as β-glucan, which are extracted from, for example, plants and fungi, are able to modulate the immune system and increase protection against diseases. However, these products are heterogeneous and their effects can be variable thus limiting their applicability and reliability...
December 28, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29283124/topical-chemotherapy-for-giant-ocular-surface-squamous-neoplasia-of-the-conjunctiva-and-cornea-is-surgery-necessary
#5
Sonal S Chaugule, Jennifer Park, Paul T Finger
PURPOSE: The purpose of this study is to report on the efficacy and safety of topical chemotherapy alone for giant ocular surface squamous neoplasia (OSSN). METHODS: In this retrospective, interventional series, 10 eyes with giant OSSN underwent exfoliative biopsy to confirm the diagnosis followed by application of interferon alpha 2b (IFN α2b) and/or 5 fluorouracil, 1% (5FU). Reported outcome measures were tumor response, visual acuity, recurrence, systemic metastasis, and treatment complications...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29259593/viral-trna-mimicry-from-a-biocommunicative-perspective
#6
REVIEW
Ascensión Ariza-Mateos, Jordi Gómez
RNA viruses have very small genomes which limits the functions they can encode. One of the strategies employed by these viruses is to mimic key factors of the host cell so they can take advantage of the interactions and activities these factors typically participate in. The viral RNA genome itself was first observed to mimic cellular tRNA over 40 years ago. Since then researchers have confirmed that distinct families of RNA viruses are accessible to a battery of cellular factors involved in tRNA-related activities...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29259162/type-i-interferon-mediated-autoinflammation-due-to-dnase-ii-deficiency
#7
Mathieu P Rodero, Alessandra Tesser, Eva Bartok, Gillian I Rice, Erika Della Mina, Marine Depp, Benoit Beitz, Vincent Bondet, Nicolas Cagnard, Darragh Duffy, Michael Dussiot, Marie-Louise Frémond, Marco Gattorno, Flavia Guillem, Naoki Kitabayashi, Fabrice Porcheray, Frederic Rieux-Laucat, Luis Seabra, Carolina Uggenti, Stefano Volpi, Leo A H Zeef, Marie-Alexandra Alyanakian, Jacques Beltrand, Anna Monica Bianco, Nathalie Boddaert, Chantal Brouzes, Sophie Candon, Roberta Caorsi, Marina Charbit, Monique Fabre, Flavio Faletra, Muriel Girard, Annie Harroche, Evelyn Hartmann, Dominique Lasne, Annalisa Marcuzzi, Bénédicte Neven, Patrick Nitschke, Tiffany Pascreau, Serena Pastore, Capucine Picard, Paolo Picco, Elisa Piscianz, Michel Polak, Pierre Quartier, Marion Rabant, Gabriele Stocco, Andrea Taddio, Florence Uettwiller, Erica Valencic, Diego Vozzi, Gunther Hartmann, Winfried Barchet, Olivier Hermine, Brigitte Bader-Meunier, Alberto Tommasini, Yanick J Crow
Microbial nucleic acid recognition serves as the major stimulus to an antiviral response, implying a requirement to limit the misrepresentation of self nucleic acids as non-self and the induction of autoinflammation. By systematic screening using a panel of interferon-stimulated genes we identify two siblings and a singleton variably demonstrating severe neonatal anemia, membranoproliferative glomerulonephritis, liver fibrosis, deforming arthropathy and increased anti-DNA antibodies. In both families we identify biallelic mutations in DNASE2, associated with a loss of DNase II endonuclease activity...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29223655/in%C3%A2-vitro-cultured-bovine-endometrial-cells-recognize-embryonic-sex
#8
E Gómez, M J Sánchez-Calabuig, D Martin, S Carrocera, A Murillo, E Correia-Alvarez, P Herrero, N Canela, A Gutiérrez-Adán, S Ulbrich, M Muñoz
Endometrial cell co-culture (ECC) with single embryo may reflect endometrium responses in vivo. Bovine Day-6 in vitro-produced morulae were cultured until Day-8 in modified synthetic oviductal fluid (mSOF), or on the epithelial side of ECC. Expression of epithelial- and stromal-cell transcripts was analyzed by RT-PCR in ECC with one male (ME) or female embryo (FE). Concentrations of ARTEMIN (ARTN) and total protein were determined in epithelial cell-conditioned medium. ECCs yielded embryos with more cells in the inner cell mass than embryos cultured in mSOF...
December 5, 2017: Theriogenology
https://www.readbyqxmd.com/read/29214086/erdheim-chester-disease-with-no-skeletal-bone-involvement-and-massive-weight-loss
#9
Hind Salama, Suleiman Kojan, Shaima Abdulrahman, Fahad Azzumeea, Ayman Alhejazi
Erdheim-Chester disease (ECD) is a rare type of non-Langerhans cell histiocytosis, with only 550 cases reported worldwide. ECD is characterized by diffuse histiocytic infiltration of multiorgans. The age of presentation of this disease is typically between 40 and 70 years. Bone disease is the most common symptom, as unique radiological findings of long bone sclerosis occur in 96% of cases. Furthermore, BRAF V600E mutation is detected in 60% of ECD cases. In this manuscript, we are describing a unique case of ECD; the patient is younger than most reported cases and has no bone pain or any skeletal involvement...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29199176/retrospective-evaluation-of-hairy-cell-leukemia-patients-treated-with-three-different-first-line-treatment-modalities-in-the-last-two-decades-a-single-center-experience
#10
Şeniz Öngören, Ahmet Emre Eşkazan, Selin Berk, Tuğrul Elverdi, Ayşe Salihoğlu, Muhlis Cem Ar, Zafer Başlar, Yıldız Aydın, Nükhet Tüzüner, Teoman Soysal
OBJECTIVE: In this study, we retrospectively analyzed the clinical outcome, treatment responses, infectious complications, and survival rates of 71 hairy cell leukemia (HCL) cases. MATERIALS AND METHODS: Sixty-seven patients received a first-line treatment and 2-chlorodeoxyadenosine (cladribine-2-CdA) was administered in 31 cases, 19 patients received interferon-alpha (INF-α), splenectomy was performed in 16 cases, and rituximab was used in one. RESULTS: Although the highest overall response rate (ORR) was observed in patients receiving 2-CdA upfront, ORRs were comparable in the 2-CdA, INF-α, and splenectomy subgroups...
December 1, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29191068/an-exploratory-cost-effectiveness-analysis-of-systemic-treatments-for-cutaneous-t-cell-lymphoma
#11
Larisa Geskin, Daniel C Malone
PURPOSE: To conduct an exploratory cost-effectiveness analysis of systemic treatment options for more advanced cutaneous T-cell lymphoma (CTCL). METHODS: A cost-effectiveness model compared systemic bexarotene, denileukin diftitox, interferon-α, methotrexate, pralatrexate, romidepsin, vorinostat, and extracorporeal photopheresis (ECP) treatment of CTCL. Treatment effectiveness data were extracted from published studies and/or US product labeling. Overall response, the primary effectiveness measure, was defined as the proportion of patients achieving complete or partial response...
December 18, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29190165/challenging-treatment-of-ocular-surface-squamous-neoplasia-in-patients-with-atopic-disease
#12
Lily Zhang, Carolina Mercado, Anat Galor, Edward J Holland, Gaofeng Wang, Carol L Karp
PURPOSE: Few studies have described ocular surface squamous neoplasia (OSSN) and its association with atopic diseases and there is no consensus on the course of OSSN in atopic patients. We thereby report three patients with atopy and OSSN. METHODS: Retrospective case series. RESULTS: Three male patients with mean age of 73 presented with OSSN and history of atopy treated with immunosuppressant therapy. Their histories included atopic dermatitis and keratoconjunctivitis...
November 30, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29189090/characterization-of-whooper-swan-cygnus-cygnus-interferon-%C3%AE-prokaryotic-expression-biological-activities-and-physicochemical-characteristics
#13
Hongjing Zhao, Yu Wang, Yizhi Shao, Juanjuan Liu, Jinglun Li, Hui Zong, Mingwei Xing
Whopper swan Cygnus cygnus interferon alpha (CyIFN-α) gene was amplified from genomic DNA in the liver of whooper swan, which encodes a 192-amino acid protein containing a 29-amino acid signal peptide. Bioinformatics analysis showed it containes 7 cysteine residues and 5 alpha helices. After expression in prokaryote, purification and renaturation, CyIFN-α was analyzed on its physicochemical property and antiviral activity. In chicken embryo fibroblasts, CyIFN-α exerted more superior anti-vesicular stomatitis virus (VSV), avian influenza virus (AIV), and Newcastle disease virus (NDV) activity than chicken IFN-α, an effective therapeutic agent used for viral infections clinically...
November 30, 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29187473/melanoma-of-the-vagina-case-report-and-systematic-review-of-the-literature
#14
Violetta Rapi, Askin Dogan, Beate Schultheis, Franziska Hartmann, Günther A Rezniczek, Clemens B Tempfer
BACKGROUND: Primary melanoma of the vagina (PMV) is a rare entity. The prognosis of women with PMV is poor and there is no standardized therapy for this type of malignancy. We present the case of a 72-year-old woman with PMV (cT2, pN0, M0). CASE REPORT: Imaging studies showed no evidence of regional or distant metastases. Molecular analysis demonstrated wild-type B-Raf proto-oncogene, serine/threonine kinase (BRAF). Staging laparoscopy with pelvic lymphadenectomy and subsequent radiotherapy with 60 Gy delivered as pelvic teletherapy and vaginal brachytherapy was applied...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29186365/high-treatment-uptake-in-hiv-hcv-coinfected-patients-after-unrestricted-access-to-direct-acting-antivirals-in-the-netherlands
#15
Anne Boerekamps, Astrid M Newsum, Colette Smit, Joop E Arends, Clemens Richter, Peter Reiss, Bart J A Rijnders, Kees Brinkman, Marc van der Valk
Background: The Netherlands has provided unrestricted access to direct-acting antivirals (DAAs) since November 2015. We analyzed the nationwide HCV treatment uptake among HIV/HCV-coinfected patients. Methods: Data were obtained from the ATHENA HIV observational cohort in which >98% of HIV-infected patients ever registered since 1998 are included. Patients were included if they ever had 1 positive HCV RNA, did not spontaneously clear and were known to still be in care...
November 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29177164/medical-therapy-of-gastrointestinal-neuroendocrine-tumors
#16
REVIEW
Kjell Öberg
Intestinal neuroendocrine tumors (NETs) constitute a heterogeneous group with duodenal, small intestinal, colonic and rectal NETs. They constitute more than half of all NETs, with the highest frequencies in the rectum, small intestine, and colon. The tumor biology varies with the location of the primary tumor as well as with the grade and staging of the tumor. Small intestinal NETs usually present low proliferation and are treated in the first line with somatostatin analogs according to current guidelines. If progression occurs, one can add interferon alpha or change the treatment to everolimus...
October 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29175211/nutlin-sensitizes-lung-carcinoma-cells-to-interferon-alpha-treatment-in-mdm2-dependent-but-p53-independent-manner
#17
Oleg Shuvalov, Alena Kizenko, Ajgul Shakirova, Olga Fedorova, Alexey Petukhov, Nikolai Aksenov, Elena Vasileva, Alexandra Daks, Nickolai Barlev
As an anticancer therapeutic, Interferon-alpha (IFNα) is used to treat a number of malignancies. However, the application of IFNα is restricted mostly due to its high toxicity. Therefore, novel combination therapeutic regimens are required to decrease the toxicity of IFNα and enhance its efficacy. Here we show that the treatment of p53-deficient human non-small lung carcinoma H1299 cells with IFNα in combination with an inhibitor of MDM2, Nutlin-3a, synergistically affects the proliferation of cancer cells...
November 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29173587/interferon-alpha-inhibits-replication-of-a-live-attenuated-porcine-reproductive-and-respiratory-syndrome-virus-vaccine-preventing-development-of-an-adaptive-immune-response-in-swine
#18
Susan L Brockmeier, Crystal L Loving, Kirsten C Eberle, Samantha J Hau, Alexandra Buckley, Albert Van Geelen, Nestor A Montiel, Tracy Nicholson, Kelly M Lager
Type I interferons, such as interferon alpha (IFN-α), contribute to innate antiviral immunity by promoting production of antiviral mediators and are also involved in promoting an adaptive immune response. Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most devastating and costly viruses to the swine industry world-wide and has been shown to induce a meager IFN-α response. Previously we administered porcine IFN-α using a replication-defective adenovirus vector (Ad5-IFN-α) at the time of challenge with virulent PRRSV and demonstrated an increase in the number of virus-specific IFNγ secreting cells, indicating that the presence of IFN-α at the time of infection can alter the adaptive immune responses to PRRSV...
December 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29171409/a-case-of-malignant-melanoma-that-developed-multiple-metastases-after-switching-from-interferon-beta-to-pegylated-interferon-alpha-2b-as-adjuvant-therapy
#19
Takeshi Fukumoto, Susumu Fujiwara, Masanobu Sakaguchi, Masahiro Oka, Chikako Nishigori
No abstract text is available yet for this article.
November 24, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29150375/type-i-interferon-and-proinflammatory-cytokine-levels-in-cerebrospinal-fluid-of-newborns-with-rotavirus-associated-leukoencephalopathy
#20
Kyung Yeon Lee, Chang Hoon Moon, Seong Hoon Choi
OBJECTIVE: The purpose of this study was to identify whether there is an increase in type I interferon and proinflammatory cytokine levels in the cerebrospinal fluid of newborns with rotavirus-associated leukoencephalopathy. METHODS: Levels of type I interferons (interferon-alpha and interferon-beta) and proinflammatory cytokines (interleukin-6 and interferon-gamma) were measured in the cerebrospinal fluid of 23 newborns with rotavirus-associated leukoencephalopathy (patient group) and 39 infants under 90 days-of-age (control group)...
November 14, 2017: Brain & Development
keyword
keyword
80596
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"