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https://www.readbyqxmd.com/read/28914658/are-the-sensory-fibers-of-the-ulnar-nerve-affected-in-carpal-tunnel-syndrome
#1
Özgür Selek, Murat Alemdar
PURPOSE: Distribution of paresthesia throughout the skin area without median nerve innervation is frequently seen in carpal tunnel syndrome (CTS). However, its pathophysiologic mechanisms are still unclear. We aimed to research whether a dysfunction in sensory fibers of the ulnar nerve (UN) was present or not in hands with CTS. METHODS: Totally, upper extremity nerve conduction study recordings of 508 patients were considered. After exclusions, 331 upper extremity recordings of 277 patients were included...
September 12, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28910165/peripapillary-choroidal-thickness-and-retinal-nerve-fiber-layer-in-untreated-patients-with-obstructive-sleep-apnea-hypopnea-syndrome-a-case-control-study
#2
Serpil Yazgan, Fatma Erboy, Haci Ugur Celik, Tacettin Ornek, Suat Hayri Ugurbas, Firuzan Kokturk, Orhan Ayar, Mehmet Orcun Akdemir, Erkan Celik
PURPOSE: To evaluate peripapillary choroidal thickness (PPCT), central macular choroidal thickness (CMCT), and retinal nerve fiber layer (RNFL) thickness in untreated patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). METHODS: This prospective, randomized, and comparative study was conducted in a university ophthalmology clinic. 106 eyes of 106 patients with OSAHS and 44 eyes of 44 healthy individuals were evaluated in this study. Only right eyes were evaluated...
September 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28895058/a-neuropathic-pain-syndrome-associated-with-hantavirus-infection
#3
Dustin Anderson, Grayson Beecher, Christopher Power, Lindsay Bridgland, Douglas W Zochodne
Hantaviruses are a group of single-stranded RNA viruses of the Bunyaviridae family. "New World" hantaviruses cause hantavirus cardiopulmonary syndrome (HCPS) in North America. HCPS carries with it significant mortality and those patients who survive the disease are often left with substantial morbidity. Neurologic complications of hantavirus infections are rare, with only sparse cases of central nervous system involvement having been documented in the literature. To our knowledge, there are no reports of hantavirus infection contributing to peripheral nervous system dysfunction...
September 11, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28894623/ethnopharmacological-values-of-cassava-and-its-potential-for-diabetes-and-dyslipidemia-management-knowledge-survey-and-critical-review-of-report
#4
Ezekiel Uba Nwose, Bonaventure C Onodu, Anayochukwu Edward Anyasodor, Mathew O Sedowo, John N Okuzor, Richard J Culas
BACKGROUND: Beyond nutritional values are the pharmacological potentials of cassava comparative with other staple carbohydrate plant-based foods such as wheat. The knowledge of applicability to diabetes and its cardiovascular complications management seems not just limited but unacknowledged. As a preliminary study, a community's knowledge of pharmacological value of cassava is investigated. METHODS: Descriptive observational study using questionnaire-based "cross-sectional" survey was conducted...
July 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28893157/basal-plate-myometrial-fibers-and-hypertensive-disorders-of-pregnancy-a-case-control-study
#5
Ann A Wang, Linda M Ernst, Emily S Miller
Introduction Basal plate myometrium (BPMYO), the pathological presence of myometrial fibers in the basal plate, is a common finding on pathological examination of the placenta, yet its clinical correlates are not well studied. As myometrial fibers are frequently located in proximity to poorly converted maternal spiral arteries, our objective was to determine whether BPMYO is associated with hypertensive disorders of pregnancy (HDP), a well-known clinical sequela of abnormal maternal artery remodeling. Methods This case-control study included women who delivered a live-born singleton gestation whose placentas were sent for pathological examination...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28891864/photosensitization-of-trpa1-and-trpv1-by-7-dehydrocholesterol-implications-for-the-smith-lemli-opitz-syndrome
#6
Alexandru Babes, Cosmin I Ciotu, Tal Hoffmann, Tatjana I Kichko, Tudor Selescu, Cristian Neacsu, Susanne K Sauer, Peter W Reeh, Michael J M Fischer
Loss of function mutations in the enzyme 7-dehydrocholesterol reductase are responsible for the Smith-Lemli-Opitz syndrome, in which 7-dehydrocholesterol (7-DHC) levels are markedly increased in the plasma and tissues of patients. This increase in 7-DHC is probably associated with the painful and itchy photosensitivity reported by the large majority of Smith-Lemli-Opitz syndrome patients. In order to identify the molecular targets involved in the activation and photosensitization of primary afferents by 7-DHC we focused on TRPA1 and TRPV1, two ion channels expressed in nociceptive nerve endings and previously shown to respond to ultraviolet and visible light under pathophysiological circumstances...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28887386/fragile-x-mental-retardation-protein-restricts-small-dye-iontophoresis-entry-into-central-neurons
#7
Tyler Kennedy, Kendal Broadie
Fragile X Mental Retardation Protein (FMRP) loss causes Fragile X syndrome (FXS), a major disorder characterized by autism, intellectual disability, hyperactivity and seizures. FMRP is both an RNA- and channel-binding regulator, with critical roles in neural circuit formation and function. However, it remains unclear how these FMRP activities relate to each other and how dysfunction in their absence underlies FXS neurological symptoms. In testing circuit level defects in the Drosophila FXS model, we discovered a completely unexpected and highly robust neuronal dye iontophoresis phenotype in the well-mapped Giant Fiber (GF) circuit...
September 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28886124/identification-and-genomic-comparison-of-temperate-bacteriophages-derived-from-emetic-bacillus-cereus
#8
Peiling Geng, Shen Tian, Zhiming Yuan, Xiaomin Hu
Cereulide-producing Bacillus cereus isolates can cause serious emetic (vomiting) syndrome and even acute lethality. As mobile genetic elements, the exploration of prophages derived from emetic B. cereus isolates will help in our understanding of the genetic diversity and evolution of these pathogens. In this study, five temperate phages derived from cereulide-producing B. cereus strains were induced, with four of them undergoing genomic sequencing. Sequencing revealed that they all belong to the Siphoviridae family, but presented in different forms in their hosts...
2017: PloS One
https://www.readbyqxmd.com/read/28877529/retinal-nerve-fiber-layer-thickness-changes-in-the-pseudoexfoliation-syndrome-a-meta-analysis-of-case-control-studies
#9
Ji-Guo Yu, Qing Huang, Xiao-Fang Zhou, Yi Ding, Jing Li, Yi Xiang
PURPOSE: To evaluate and compare changes in retinal nerve fiber layer (RNFL) thickness in patients with the pseudoexfoliation syndrome (PXS) and healthy controls. METHODS: Case-control studies were selected through an electronic search of the Cochrane Controlled Trials Register, PubMed, and Embase. Results were reviewed to ensure that the included studies met prespecified inclusion/exclusion criteria, and the quality of each study was assessed using the Newcastle-Ottawa Scale...
September 7, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28875340/corneal-features-in-ocular-graft-versus-host-disease-by-in-vivo-confocal-microscopy
#10
Tudor C Tepelus, Gloria B Chiu, Jyotsna Maram, Jianyan Huang, Vikas Chopra, SriniVas R Sadda, Olivia L Lee
PURPOSE: The purpose of our study was to determine the morphological features of the corneal epithelial layers, sub-basal nerve plexus and anterior stroma in patients with ocular graft-versus-host disease (oGVHD) compared to non-GVHD dry eyes and normal controls, using in vivo confocal microscopy (IVCM). METHODS: IVCM was used to capture central cornea images from eight volunteers with normal healthy eyes, ten patients with non-GVHD dry eye syndrome (DES) and 15 patients with clinically diagnosed oGVHD, in a cross-sectional study...
September 5, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28867325/neuroprotective-effects-of-valproic-acid-in-a-rat-model-of-cauda-equina-injury
#11
Qing-Jie Kong, Yuan Wang, Yang Liu, Jing-Chuan Sun, Xi-Ming Xu, Xiao-Fei Sun, Jian-Gang Shi
BACKGROUND: Histone deacetylase inhibitors (HDACi), including valproic acid (VPA), are promising therapeutic interventions in neurological disorders and play an important role in synaptic activity and neuronal function. MATERIAL AND METHODS: A total of 30 rats were randomly allocated to three groups: sham, control, and VPA. The rats in the VPA and control groups received laminectomy at the L4 level of the vertebrae and silicone gel implantation into the epdidural spaces L5 and L6...
August 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28856555/retinal-thickness-as-a-marker-of-disease-progression-in-longitudinal-observation-of-patients-with-wolfram-syndrome
#12
Agnieszka Zmyslowska, Wojciech Fendler, Arleta Waszczykowska, Anna Niwald, Maciej Borowiec, Piotr Jurowski, Wojciech Mlynarski
AIMS: Wolfram syndrome (WFS) is a recessively inherited monogenic form of diabetes coexisting with optic atrophy and neurodegenerative disorders with no currently recognized markers of disease progression. The aim of the study was to evaluate retinal parameters by using optical coherence tomography (OCT) in WFS patients after 2 years of follow-up and analysis of the parameters in relation to visual acuity. METHODS: OCT parameters and visual acuity were measured in 12 WFS patients and 31 individuals with type 1 diabetes...
August 30, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28852159/loss-of-the-podocyte-glucocorticoid-receptor-exacerbates-proteinuria-after-injury
#13
Han Zhou, Xuefei Tian, Alda Tufro, Gilbert Moeckel, Shuta Ishibe, Julie Goodwin
Nephrotic syndrome is a common disorder in adults and children whose etiology is largely unknown. Glucocorticoids remain the mainstay of therapy in most cases, though their mechanism of action remains poorly understood. Emerging evidence suggests that immunomodulatory therapies used in nephrotic syndrome directly target the podocytes. To study how steroids directly affect the podocytes in the treatment of proteinuria, we created a mouse model with podocyte-specific deletion of the glucocorticoid receptor. The podocyte-specific glucocorticoid receptor (GR) knockout mice had similar renal function and protein excretion compared to wild type...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845373/first-case-report-of-metastatic-squamous-cell-carcinoma-of-lung-associated-with-mounier-kuhn-syndrome-and-review-of-literature
#14
Fatima Ayub, Muhammad W Saif
Mounier-Kuhn syndrome is a relatively rare condition, mostly involving the trachea and main stem bronchi. It is caused either by the atrophy of elastic fibers or faulty fetal development of cartilage and smooth muscles, hence leading to an overall increase in the diameter of lower respiratory tract. No certain etiology was found in the majority of cases reported previously, however, several other connective tissue diseases have also been implicated with the congenital tracheobronchomegaly. One anecdotal case report mentioned the development of lung malignancy in a patient who had previously received external beam radiotherapy...
June 26, 2017: Curēus
https://www.readbyqxmd.com/read/28845322/intraocular-pressure-and-retinal-nerve-fibre-layer-thickness-changes-after-carotid-artery-stenting
#15
Esra Biberoğlu, Muhsin Eraslan, Feyyaz Baltacıoğlu, İpek Midi
OBJECTIVES: The aim of this study was to evaluate intraocular pressure (IOP) and retinal nerve fiber layer (RNFL) changes in patients with carotid artery stenosis (CAS) after carotid artery stenting. MATERIALS AND METHODS: This study was conducted as a cross-sectional, non-randomised clinical case series. Fifteen male patients (mean age: 63.6±9.1) with CAS and more than 70% carotid artery narrowing were included. All of the patients were followed in the department of neurology and were operated in the interventional radiology division...
August 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28842217/cytoskeleton-related-regulation-of-primary-cilia-shortening-mediated-by-melanin-concentrating-hormone-receptor-1
#16
Sakura Tomoshige, Yuki Kobayashi, Kosuke Hosoba, Akie Hamamoto, Tatsuo Miyamoto, Yumiko Saito
Primary cilia are specialized microtubule-based organelles. Their importance is highlighted by the gamut of ciliary diseases associated with various syndromes including diabetes and obesity. Primary cilia serve as signaling hubs through selective interactions with ion channels and conventional G-protein-coupled receptors (GPCRs). Melanin-concentrating hormone (MCH) receptor 1 (MCHR1), a key regulator of feeding, is selectively expressed in neuronal primary cilia in distinct regions of the mouse brain. We previously found that MCH acts on ciliary MCHR1 and induces cilia shortening through a Gi/o-dependent Akt pathway with no cell cycle progression...
August 22, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28840949/hidden-in-the-heart-a-peculiar-type-of-left-ventricular-remodeling-after-acute-myocardial-infarction
#17
Marianna Cicenia, Francesco Fedele, Valentina Petronilli, Carlotta De Carlo, Federica Moscucci, Mauro Schina, Susanna Sciomer
We reported an unusual case of left ventricular pouch, in a 72-year-old man who had an acute coronary syndrome treated with percutaneous revascularization. The echocardiogram showed a sort of pouch, delimited by epicardium and endocardium, confirmed by 3D echo. This finding appeared as an echo free area, with a really slight color flow inside. We consequently supposed it would be a dissecting hematoma, a rare complication of the ischemic disease, due to the rupture of the intramyocardial vessels among the spiral myocardial fibers...
August 25, 2017: Echocardiography
https://www.readbyqxmd.com/read/28839045/actin-protects-mammalian-eggs-against-chromosome-segregation-errors
#18
Binyam Mogessie, Melina Schuh
Chromosome segregation is driven by a spindle that is made of microtubules but is generally thought to be independent of actin. Here, we report an unexpected actin-dependent mechanism that drives the accurate alignment and segregation of chromosomes in mammalian eggs. Prominent actin filaments permeated the microtubule spindle in eggs of several mammalian species, including humans. Disrupting actin in mouse eggs led to significantly increased numbers of misaligned chromosomes as well as lagging chromosomes during meiosis I and II...
August 25, 2017: Science
https://www.readbyqxmd.com/read/28831021/a-systems-approach-for-discovering-linoleic-acid-derivatives-that-potentially-mediate-pain-and-itch
#19
Christopher E Ramsden, Anthony F Domenichiello, Zhi-Xin Yuan, Matthew R Sapio, Gregory S Keyes, Santosh K Mishra, Jacklyn R Gross, Sharon Majchrzak-Hong, Daisy Zamora, Mark S Horowitz, John M Davis, Alexander V Sorokin, Amit Dey, Danielle M LaPaglia, Joshua J Wheeler, Michael R Vasko, Nehal N Mehta, Andrew J Mannes, Michael J Iadarola
Chronic pain and itch are common hypersensitivity syndromes that are affected by endogenous mediators. We applied a systems-based, translational approach to predict, discover, and characterize mediators of pain and itch that are regulated by diet and inflammation. Profiling of tissue-specific precursor abundance and biosynthetic gene expression predicted that inflamed skin would be abundant in four previously unknown 11-hydroxy-epoxy- or 11-keto-epoxy-octadecenoate linoleic acid derivatives and four previously identified 9- or 13-hydroxy-epoxy- or 9- or 13-keto-epoxy-octadecenoate linoleic acid derivatives...
August 22, 2017: Science Signaling
https://www.readbyqxmd.com/read/28817717/short-report-trpv1-polymorphism-1911-a-g-alters-capsaicin-induced-sensory-changes-in-healthy-subjects
#20
Julia Forstenpointner, Matti Förster, Denisa May, Friederike Hofschulte, Ingolf Cascorbi, Gunnar Wasner, Janne Gierthmühlen, Ralf Baron
BACKGROUND: C-fibers express transient receptor potential (TRP) channels. These high-voltage gated channels function as integrators of different physical stresses (e.g. heat, protons, ATP). Additionally channel activation can be induced by capsaicin. Topically applied, capsaicin elicits burning pain, heat and mechanical hyperalgesia and serves as a human surrogate model for pain. It was suggested that the TRPV1-variant rs8065080 (1911A>G) plays a pivotal role in patients with neuropathic pain syndromes...
2017: PloS One
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