keyword
https://read.qxmd.com/read/38493538/jaboticaba-peel-improves-postprandial-glucose-and-inflammation-a-randomized-controlled-trial-in-adults-with-metabolic-syndrome
#1
JOURNAL ARTICLE
Marina Vilar Geraldi, Ágatta Caroline de Souza, Marina Maintinguer Norde, Paulo Roberto Berni, Lívia Mateus Reguengo, Bruno Geloneze, Mario Roberto Marostica
The modulation of glucose metabolism through dietary sources has been recognized as 1 of the most sustainable approaches for preventing of cardiometabolic diseases. Although fibers and phenolic compounds derived from jaboticaba (Plinia jaboticaba) peel have demonstrated improvements in metabolic pathways in preclinical models, their beneficial effects in clinical trials remain to be fully determined. This study aimed to assess the impact of jaboticaba peel (JP) powder supplementation on glucose metabolism compared with a placebo in individuals with metabolic syndrome (MetS)...
February 28, 2024: Nutrition Research
https://read.qxmd.com/read/38486305/italian-guidelines-for-the-management-of-irritable-bowel-syndrome-in-children-and-adolescents-joint-consensus-from-the-italian-societies-of-gastroenterology-hepatology-and-pediatric-nutrition-sigenp-pediatrics-sip-gastroenterology-and-endoscopy-sige-and-neurogastroenterology
#2
REVIEW
Giovanni Di Nardo, Giovanni Barbara, Osvaldo Borrelli, Cesare Cremon, Valentina Giorgio, Luigi Greco, Michele La Pietra, Giovanni Marasco, Licia Pensabene, Marisa Piccirillo, Claudio Romano, Silvia Salvatore, Michele Saviano, Vincenzo Stanghellini, Caterina Strisciuglio, Renato Tambucci, Rossella Turco, Letizia Zenzeri, Annamaria Staiano
The irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), whose prevalence has widely increased in pediatric population during the past two decades. The exact pathophysiological mechanism underlying IBS is still uncertain, thus resulting in challenging diagnosis and management. Experts from 4 Italian Societies participated in a Delphi consensus, searching medical literature and voting process on 22 statements on both diagnosis and management of IBS in children. Recommendations and levels of evidence were evaluated according to the grading of recommendations, assessment, development, and evaluation (GRADE) criteria...
March 14, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38484117/nutritional-composition-and-therapeutic-potential-of-pineapple-peel-a-comprehensive-review
#3
JOURNAL ARTICLE
Arshad Farid, Mahrukh Mehraj, Susmita Das, Fathima Feroz, Ab Waheed Wani, S Q Dar, Sanjeev Kumar, Atif Khurshid Wani
Pineapple (Ananas comosus), the succulent and vibrant tropical fruit, is a symbol of exoticism and sweetness. The pineapple peel, often considered as waste, has garnered attention for its potential applications. The pineapple peel is rich in essential nutrients, including calcium, potassium, vitamin C, carbohydrates, dietary fiber, and water, making it beneficial for the digestive system, weight management, and overall balanced nutrition. It contains significant amounts of sugars such as sucrose, glucose, and fructose, along with citric acid as the predominant organic acid...
March 14, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38475968/large-scale-bioreactor-production-of-extracellular-vesicles-from-mesenchymal-stromal-cells-for-treatment-of-acute-radiation-syndrome
#4
JOURNAL ARTICLE
John A Kink, Michael A Bellio, Matthew H Forsberg, Alexandra Lobo, Anna S Thickens, Bryson M Lewis, Irene M Ong, Aisha Khan, Christian M Capitini, Peiman Hematti
BACKGROUND: Hematopoietic acute radiation syndrome (H-ARS) occurring after exposure to ionizing radiation damages bone marrow causing cytopenias, increasing susceptibility to infections and death. We and others have shown that cellular therapies like human mesenchymal stromal cells (MSCs), or monocytes/macrophages educated ex-vivo with extracellular vesicles (EVs) from MSCs were effective in a lethal H-ARS mouse model. However, given the complexity of generating cellular therapies and the potential risks of using allogeneic products, development of an "off-the-shelf" cell-free alternative like EVs may have utility in conditions like H-ARS that require rapid deployment of available therapeutics...
March 13, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38470115/pain-in-the-context-of-sensory-deafferentation
#5
JOURNAL ARTICLE
Steven P Cohen, Michael J Caterina, Su-Yin Yang, Mariano Socolovsky, Claudia Sommer
Pain that accompanies deafferentation is one of the most mysterious and misunderstood medical conditions. Prevalence rates for the assorted conditions vary considerably but the most reliable estimates are greater than 50% for strokes involving the somatosensory system, brachial plexus avulsions, spinal cord injury, and limb amputation, with controversy surrounding the mechanistic contributions of deafferentation to ensuing neuropathic pain syndromes. Deafferentation pain has also been described for loss of other body parts (e...
April 1, 2024: Anesthesiology
https://read.qxmd.com/read/38464934/postoperative-abdominal-herpes-zoster-complicated-by-intestinal-obstruction-a-case-report
#6
Zhen-Yu Dong, Rui-Xian Shi, Xiao-Biao Song, Ming-Yue Du, Ji-Jun Wang
BACKGROUND: Intestinal obstruction is a common occurrence in clinical practice. However, the occurrence of herpes zoster complicated by intestinal obstruction after abdominal surgery is exceedingly rare. In the diagnostic and treatment process, clinicians consider it crucial to identify the primary causes of its occurrence to ensure effective treatment and avoiding misdiagnosis. CASE SUMMARY: Herein, we present the case of a 40-year-old female patient with intestinal obstruction who underwent laparoscopic appendectomy and developed herpes zoster after surgery...
February 26, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38463938/the-impacts-of-dietary-sphingomyelin-supplementation-on-metabolic-parameters-of-healthy-adults-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
Chen-Zi Li, Li-Mei Wu, Chen-Xi Zhu, Huan-Yu Du, Guo-Xun Chen, Fang Yang
BACKGROUND: Studies have shown that sphingomyelin (SM) and its metabolites play signaling roles in the regulation of human health. Endogenous SM is involved in metabolic syndrome (MetS), while dietary SM supplementation may maintain lipid metabolism and prevent or alleviate MetS. Therefore, we hypothesized that dietary SM supplementation is beneficial for human health. AIMS: In order to examine the impacts of dietary SM on metabolic indexes in adults without MetS, we performed a meta-analysis to test our hypothesis...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38461853/pathophysiology-of-overactive-bladder-and-pharmacologic-treatments-including-%C3%AE-3-adrenoceptor-agonists-basic-research-perspectives
#8
JOURNAL ARTICLE
Joonbeom Kwon, Duk Yoon Kim, Kang Jun Cho, Mamoru Hashimoto, Kanako Matsuoka, Tadanobu Kamijo, Zhou Wang, Sergei Karnup, Anne M Robertson, Pradeep Tyagi, Naoki Yoshimura
Overactive bladder (OAB) is a symptom-based syndrome defined by urinary urgency, frequency, and nocturia with or without urge incontinence. The causative pathology is diverse; including bladder outlet obstruction (BOO), bladder ischemia, aging, metabolic syndrome, psychological stress, affective disorder, urinary microbiome, localized and systemic inflammatory responses, etc. Several hypotheses have been suggested as mechanisms of OAB generation; among them, neurogenic, myogenic, and urothelial mechanisms are well-known hypotheses...
February 2024: International Neurourology Journal
https://read.qxmd.com/read/38459857/-surgical-therapy-of-slipping-rib-syndrome
#9
JOURNAL ARTICLE
Yoshio Tsunezuka, Syusei Endo, Yoshitaka Tanaka, Toshihiro Hinokuma
We have operated on two cases of slipped ribs syndrome( SRS). Both patients were men in their 40s with a history of right thoracic trauma who were referred to us because of unexplained lower thoracic pain. The left rib was positive for hooking maneuver (lift test), and dynamic ultrasonography showed narrowing of the intercostal space, which led to the diagnosis of SRS. in the first case, the tip of the ninth rib cartilage was excised, and the ninth and tenth rib cartilages were sutured and fixed with No.2 fiber wire in two places with Z sutures...
February 2024: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://read.qxmd.com/read/38458181/becoming-a-world-champion-powerlifter-at-71%C3%A2-years-of-age-it-is-never-too-late-to-start-exercising
#10
JOURNAL ARTICLE
Cas J Fuchs, Jorn Trommelen, Michelle E G Weijzen, Joey S J Smeets, Janneau van Kranenburg, Lex B Verdijk, Luc J C van Loon
This case study assessed body composition, muscle strength, cardiorespiratory fitness, and metabolic health of the present female world champion powerlifter in the 70+ age category who started resistance exercise training at 63 years of age with no prior experience with structured exercise training. Measures of body composition (magnetic resonance imaging, computed tomography, and dual-energy X-ray absorptiometry scanning, leg volume); strength (one-repetition maximum leg press and extension, maximum voluntary contraction, and handgrip strength); physical function (short physical performance battery); cardiorespiratory fitness (peak oxygen consumption); and metabolic health (oral glucose tolerance test) were assessed...
March 7, 2024: International Journal of Sport Nutrition and Exercise Metabolism
https://read.qxmd.com/read/38450461/-structural-and-functional-features-of-the-eye-in-marfan-syndrome-report-2-changes-in-the-anatomical-complex-of-the-lens
#11
JOURNAL ARTICLE
K S Avetisov, E A Chizhonkova, S E Avetisov, D V Andzhelova
UNLABELLED: Analysis of lens changes in Marfan syndrome (MS), in addition to assessing the position of the lens itself, should include the possibility of examining its supporting and accommodative components (ciliary zonule and ciliary body), or what can be called the entire anatomical complex of the lens. Optical methods of studying the structures of the anterior segment of the eye, due to iris opacity, allow only to analyze the state of the lens within the natural or medically enlarged pupil width...
2024: Vestnik Oftalmologii
https://read.qxmd.com/read/38449932/hair-tourniquet-syndrome-involving-the-uvula-secondary-to-an-airway-foreign-body
#12
Theresa A Schneider, Jatin Ahluwalia, Ani Mnatsakanian, Michael Haupert
Hair tourniquet syndrome is a rare condition that can cause ischemia and necrosis secondary to hair fibers constricting a patient's appendages. Typically, the syndrome affects patients aged two to six months. Hair tourniquet syndrome often involves the toes, fingers, or genitalia, and it has been rarely reported to have oropharyngeal manifestations. Accurate and timely treatment of this syndrome is imperative to save the involved appendage. We discuss a case of a six-month-old female who presented to the emergency room (ER) with increased agitation and was found to have hair tourniquet syndrome of the uvula, requiring the removal of the foreign body in the operating room (OR)...
February 2024: Curēus
https://read.qxmd.com/read/38443406/gut-dysbiosis-is-linked-to-metabolic-syndrome-in-obese-egyptian-women-potential-treatment-by-probiotics-and-high-fiber-diets-regimen
#13
JOURNAL ARTICLE
Nayera E Hassan, Sahar A El-Masry, Salwa M El Shebini, Nihad H Ahmed, Fouad Mohamed T, Mohammed I Mostafa, Mahmoud A S Afify, Ayat N Kamal, Mai M Badie, Adel Hashish, Khadija Alian
Metabolic syndrome (MetS) is defined as a cluster of glucose intolerance, hypertension, dyslipidemia, and central obesity with insulin resistance. The role of gut microbiota in metabolic disorders is increasingly considered. To investigate the effects of probiotic supplements and hypocaloric high fiber regimen on MetS in obese Egyptian women. A longitudinal follow-up intervention study included 58 obese Egyptian women, with a mean age of 41.62 ± 10.70 years. They were grouped according to the criteria of MetS into 2 groups; 23 obese women with MetS and 35 ones without MetS...
March 5, 2024: Scientific Reports
https://read.qxmd.com/read/38435541/anatomical-bases-of-the-temporal-muscle-trigger-points
#14
JOURNAL ARTICLE
Luis Carlos Fernandez Garrido, Giulianna Simonetti, Samir Omar Saleh, Flávio Hojaij, Mauro Andrade, Alfredo Luiz Jacomo, Flavia Emi Akamatsu
METHOD: Temporal muscles of 14 adult cadavers were studied. The muscle bellies were divided into six areas, three superior (1.2 and 3) and three inferior areas (4, 5, and 6) lower, according to a Cartesian plane to analyze and describe the entry points of the branches of the deep temporal nerves into the muscle. The branching distribution was analyzed using Poisson log-linear tests with Bonferroni post hoc tests for comparison between groups (sextants) ( p < 0.05). RESULTS: Deep temporal nerve entry points were found in the temporal muscle in all areas...
2024: BioMed Research International
https://read.qxmd.com/read/38433265/heterozygous-thbs2-pathogenic-variant-causes-ehlers-danlos-syndrome-with-prominent-vascular-features-in-humans-and-mice
#15
JOURNAL ARTICLE
Noam Hadar, Omri Porgador, Idan Cohen, Hilla Levi, Vadim Dolgin, Yuval Yogev, Sufa Sued-Hendrickson, Ilan Shelef, Elena Didkovsky, Marina Eskin-Schwartz, Ohad S Birk
Ehlers-Danlos syndromes (EDS) are a group of connective tissue disorders caused by mutations in collagen and collagen-interacting genes. We delineate a novel form of EDS with vascular features through clinical and histopathological phenotyping and genetic studies of a three-generation pedigree, displaying an apparently autosomal dominant phenotype of joint hypermobility and frequent joint dislocations, atrophic scarring, prolonged bleeding time and age-related aortic dilatation and rupture. Coagulation tests as well as platelet counts and function were normal...
March 4, 2024: European Journal of Human Genetics: EJHG
https://read.qxmd.com/read/38423434/highly-crystalline-cellulose-microparticles-from-dealginated-seaweed-waste-ameliorate-high-fat-sugar-diet-induced-hyperlipidemia-in-mice-by-modulating-gut-microbiota
#16
JOURNAL ARTICLE
Shiying Tang, Xiuyu Dong, Yueyun Ma, Hui Zhou, Yunhai He, Dandan Ren, Xiang Li, Yidi Cai, Qiukuan Wang, Long Wu
The effects of seaweed cellulose (SC) on high fat-sugar diet (HFSD)-induced glucolipid metabolism disorders in mice and potential mechanisms were investigated. SC was isolated from dealginated residues of giant kelp (Macrocystis pyrifera), with a crystallinity index of 85.51 % and an average particle size of 678.2 nm. Administering SC to C57BL/6 mice at 250 or 500 mg/kg BW/day via intragastric gavage for six weeks apparently inhibited the development of HFSD-induced obesity, dyslipidemia, insulin resistance, oxidative stress and liver damage...
February 27, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38401400/development-of-an-elisa-for-the-detection-of-fowl-adenovirus-serotype-4-utilizing-fiber-protein
#17
JOURNAL ARTICLE
Faiza Ather, Muhammad Ashir Zia, Mudasser Habib, Muhammad Salah-Ud-Din Shah
Hydropericardium syndrome (HPS), caused by the Fowl adenovirus 4 (FAdV-4) has led to significant financial losses for the poultry industry globally, including Pakistan over the past few years. Conventional serological methods are time consuming, laborious and less sensitive therefore, a rapid and sensitive ELISA kit is required for the reliable detection of FAdV-4 infection. In the current research, fiber proteins (1 &2) of FAdV-4 were successfully expressed in Escherichia coli and purified using metal affinity chromatography...
February 23, 2024: Biologicals: Journal of the International Association of Biological Standardization
https://read.qxmd.com/read/38399637/the-potential-impact-of-probiotics-on-human-health-an-update-on-their-health-promoting-properties
#18
REVIEW
Nicoleta-Maricica Maftei, Cosmin Raducu Raileanu, Alexia Anastasia Balta, Lenuta Ambrose, Monica Boev, Denisa Batîr Marin, Elena Lacramioara Lisa
Probiotics, known to be live microorganisms, have been shown to improve or restore the gut microbiota, which in turn has been linked to improved health. It is believed that probiotics are the modern equivalent of a panacea, with claims that they may treat or prevent different diseases both in children and adults (e.g., from colic in babies to cardiovascular disease, respiratory infection, and cancer in adults). Ever since the early 2000s, probiotic-based fermented foods have had a resurgence in popularity, mostly due to claims made regarding their health benefits...
January 23, 2024: Microorganisms
https://read.qxmd.com/read/38387409/critical-roles-of-pai-1-in-lipopolysaccharide-induced-acute-lung-injury
#19
JOURNAL ARTICLE
Miao Li, Juan Song, Xinjun Tang, Jing Bi, Yufan Li, Cuicui Chen, Nana Feng, Yuanlin Song, Linlin Wang
PURPOSE: Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of fibrinolytic systems. The effect of PAI-1 on inflammatory response is still inconsistent. Our study was conducted to investigate its effects on inflammation to clarify the role of PAI-1 in acute lung injury (ALI) induced by lipopolysaccharide (LPS). MATERIAL AND METHODS: ALI models were established in wild-type (WT) and PAI-1 knockout (KO) mice by LPS intervention for 48 ​h. Lung histopathology, wet-dry ratio, total cell count and TNF-α concentration in bronchoalveolar lavage fluid (BALF), and inflammation related proteins were detected...
February 21, 2024: Advances in Medical Sciences
https://read.qxmd.com/read/38384954/digestive-problems-in-rabbit-production-moving-in-the-wrong-direction
#20
JOURNAL ARTICLE
Malou van der Sluis, Yvonne R A van Zeeland, Karel H de Greef
Digestive problems, both those with a clear pathogenic origin (e.g., Escherichia coli ) and those without obvious pathogen involvement [e.g., syndromes like epizootic rabbit enteropathy (ERE)], are common in production rabbits and account for the majority of losses in meat rabbit production. A multitude of nutritional, genetic and housing factors have been found to play a role in the occurrence of digestive problems. However, the exact early pathophysiological mechanism, including the links between aforementioned risk factors and subsequent development and expression of gastrointestinal disease, is less clear, especially in non-specific enteropathies without obvious pathogen involvement...
2024: Frontiers in Veterinary Science
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