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https://www.readbyqxmd.com/read/28230737/role-of-fiber-in-symptomatic-uncomplicated-diverticular-disease-a-systematic-review
#1
REVIEW
Marilia Carabotti, Bruno Annibale, Carola Severi, Edith Lahner
Symptomatic uncomplicated diverticular disease (SUDD) is a syndrome characterized by recurrent abdominal symptoms in patients with colonic diverticula. There is some evidence that a high-fiber diet or supplemental fibers may reduce symptoms in SUDD patients and a high-fiber diet is commonly suggested for these patients. This systematic review aims to update the evidence on the efficacy of fiber treatment in SUDD, in terms of a reduction in symptoms and the prevention of acute diverticulitis. According to PRISMA, we identified studies on SUDD patients treated with fibers (PubMed and Scopus)...
February 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28228619/a-case-of-anti-3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-antibody-positive-paraneoplastic-necrotizing-myopathy-associated-with-advanced-gastric-cancer-that-responded-to-intravenous-immunoglobulin-therapy
#2
Tomohisa Yamaguchi, Akiko Matsunaga, Masamichi Ikawa, Norimichi Shirafuji, Ichizo Nishino, Tadanori Hamano
A 49-year-old woman presented with progressive muscle weakness of the limbs and dysphagia. Her past and family medical history were unremarkable and she did not take statins or any other medications. Laboratory tests showed that serum levels of creatine kinase were elevated (13,565 IU/l) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies were detected in the serum. Other autoantibodies to the nuclear (ANA), RNP, aminoacyl-tRNA synthetases (ARS), and signal recognition particle (SRP) were negative...
February 22, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28221312/what-s-in-the-literature
#3
David Lacomis, Nicholas J Silvestri, Edward J Fine, Gil I Wolfe
In this edition of this column, we review new studies concerning the pathophysiology, treatment, and outcomes of patients with necrotizing myopathy, genetic testing in congenital myopathies, and limb girdle muscular dystrophies, and the incidence of polyneuropathy in the myotonic dystrophies. Various studies in myasthenia gravis, including those concerning antibody testing, clinical features, and quality of life are also reviewed as are recent findings in congenital myasthenic syndromes. Finally, 2 studies concerning polyneuropathy are discussed, including one on the association of polyneuropathy in patients with the metabolic syndrome and one on laboratory testing in patients with otherwise idiopathic small fiber polyneuropathy...
March 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/28219317/dietary-fiber-gap-and-host-gut-microbiota
#4
Meng Han, Ping Liu, Defa Li, Yuan Li, Xi Ma
Accumulating evidence are dramatically increasing access to the facts that the gut microbiota plays a pivotal role in host metabolism and health, which revealed the possibility of a plethora of associations between gut bacteria and human diseases. Several functional roles carried out by a major class of host's diet, such as fiber. Fiber is the main source of microbiota-accessible carbohydrate in the diet of humans. In modern diet, it is difficult to intake dietary fiber as enough as recommended standard. The low-fiber diet in the modern life, known as fiber gap, can trigger to a substantial depletion of the human gut microbiota diversity and beneficial metabolites...
February 20, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28206686/nte-pnpla6-is-expressed-in-mature-schwann-cells-and-is-required-for-glial-ensheathment-of-remak-fibers
#5
Janis McFerrin, Bruce L Patton, Elizabeth R Sunderhaus, Doris Kretzschmar
Neuropathy target esterase (NTE) or patatin-like phospholipase domain containing 6 (PNPLA6) was first linked with a neuropathy occurring after organophosphate poisoning and was later also found to cause complex syndromes when mutated, which can include mental retardation, spastic paraplegia, ataxia, and blindness. NTE/PNPLA6 is widely expressed in neurons but experiments with its Drosophila orthologue Swiss-cheese (SWS) suggested that it may also have glial functions. Investigating whether NTE/PNPLA6 is expressed in glia, we found that NTE/PNPLA6 is expressed by Schwann cells in the sciatic nerve of adult mice with the most prominent expression in nonmyelinating Schwann cells...
February 16, 2017: Glia
https://www.readbyqxmd.com/read/28202702/congenital-myopathy-associated-with-the-triadin-knockout-syndrome
#6
Andrew G Engel, Keeley R Redhage, David J Tester, Michael J Ackerman, Duygu Selcen
OBJECTIVE: Triadin is a component of the calcium release complex of cardiac and skeletal muscle. Our objective was to analyze the skeletal muscle phenotype of the triadin knockout syndrome. METHODS: We performed clinical evaluation, analyzed morphologic features by light and electron microscopy, and immunolocalized triadin in skeletal muscle. RESULTS: A 6-year-old boy with lifelong muscle weakness had a triadin knockout syndrome caused by compound heterozygous null mutations in triadin...
February 15, 2017: Neurology
https://www.readbyqxmd.com/read/28188469/investigation-of-interaction-phenomena-between-crural-fascia-and-muscles-by-using-a-three-dimensional-numerical-model
#7
Piero G Pavan, Paola Pachera, Antonella Forestiero, Arturo N Natali
The focus of this work is the numerical modeling of the anterior compartment of the human leg with particular attention to crural fascia. Interaction phenomena between fascia and muscles are of clinical interest to explain some pathologies, as the compartment syndrome. A first step to enhance knowledge on this topic consists in the investigation of fascia biomechanical role and its interaction with muscles in physiological conditions. A three-dimensional finite element model of the anterior compartment is developed based on anatomical data, detailing the structural conformation of crural fascia, composed of three layers, and modeling the muscles as a unique structure...
February 10, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28187365/low-glycemic-load-diets-protect-against-metabolic-syndrome-and-type-2-diabetes-mellitus-in-the-male-nile-rat
#8
Julia Bolsinger, Michelle Landstrom, Andrzej Pronczuk, Andrew Auerbach, K C Hayes
BACKGROUND: Dietary modification helps prevent and manage Metabolic Syndrome (MetS) and Type 2 Diabetes Mellitus (T2DM) in humans and Nile rats. Specifically fibrous legumes, like lentils, benefit humans, but whether this reflects a specific change in the Glycemic Load (GLoad) remains controversial. Accordingly, low-GLoad foods were tested in the glucose-sensitive Nile rat. METHODS: 131 male Nile rats aged 3 weeks to 15 months were challenged during four experiments with 15 dietary exposures that varied Glycemic Index (GI, 36-88), GLoad (102-305/2000 kcal), and cumulative GLoad (Cum GLoad=days×GLoad, 181-537g total glucose)...
January 26, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28168180/association-between-nutrient-intake-and-metabolic-syndrome-in-patients-with-colorectal-cancer
#9
Hee-Sook Lim, Eung-Jin Shin, Jeong-Won Yeom, Yoon-Hyung Park, Soon-Kyung Kim
The purpose of this study was to investigate the difference of nutritional status according to metabolic syndrome in colorectal cancer patients. The subjects were divided into 2 groups (metabolic syndrome group and normal group) according to the presence or absence of metabolic syndrome in 143 patients diagnosed with colorectal cancer, and their lifestyle and nutritional status were analyzed. Recall method was used for the dietary survey, and metabolic syndrome was defined as the presence of 3 or more of waist circumference, fasting blood glucose, triglyceride, high-density lipoprotein (HDL)-cholesterol, and blood pressure...
January 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/28162043/chest-ultrasonography-in-health-surveillance-of-asbestos-related-lung-diseases
#10
Andrea Smargiassi, Giuliana Pasciuto, Ilaria Pedicelli, Erminia Lo Greco, Mariarosaria Calvello, Riccardo Inchingolo, Gioacchino Schifino, Patrizio Capoluongo, Pasquale Patriciello, Maurizio Manno, Alfonso Cirillo, Giuseppe Maria Corbo, Gino Soldati, Ivo Iavicoli
OBJECTIVES: Exposure to asbestos fibers can lead to different lung diseases, such as pleural thickening and effusion, asbestosis, mesothelioma, and lung cancer. These diseases are expected to peak in the next few years. The aim of the study was to validate ultrasonography (US) as a diagnostic tool in the management of lung diseases in subjects with a history of occupational exposure to asbestos. METHODS: Fifty-nine retired male workers previously exposed to asbestos were enrolled in the study...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28144165/osteosarcopenic-obesity-in-women-impact-prevalence-and-management-challenges
#11
REVIEW
Pegah JafariNasabian, Julia E Inglis, Owen J Kelly, Jasminka Z Ilich
Osteosarcopenic obesity syndrome (OSO) has recently been identified as a condition encompassing osteopenia/osteoporosis, sarcopenia and obesity. OSO is especially deleterious in older adults (even if they are not obese by conventional measures), due to age-related redistribution of fat and its infiltration into bone and muscle. Osteoporosis and bone fractures in elderly increase the risk of sarcopenia, which, through decreased mobility, increases the risk of more falls and fractures, creating a vicious cycle...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28128860/assessment-of-small-sensory-fiber-function-across-the-spectrum-of-severity-in-carpal-tunnel-syndrome-patients
#12
Christopher Clarke, Christopher Christensen, Matthew W T Curran, K Ming Chan
INTRODUCTION: In compressive neuropathies, large myelinated nerve fibers are generally thought to be more susceptible. In this study, we investigated small myelinated Aδ and unmyelinated C fiber function in patients with mild, moderate, and severe carpal tunnel syndrome. METHODS: Forty-four healthy controls and 81 carpal tunnel syndrome patients in the mild, moderate, or severe categories were recruited. Small fiber sensation in the affected hand was determined with quantitative sensory testing...
January 27, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28126369/neonatal-bladder-inflammation-induces-long-term-visceral-pain-and-altered-responses-of-spinal-neurons-in-adult-rats
#13
Pradeep Kannampalli, Reji Babygirija, Jiang Zhang, Michael M Poe, Guanguan Li, James M Cook, Reza Shaker, Banani Banerjee, Jyoti N Sengupta
Painful events early in life have been shown to increase the incidence of interstitial cystitis/painful bladder syndrome in adulthood. However, the intrinsic mechanism is not well studied. We previously reported that neonatal bladder inflammation causes chronic visceral hypersensitivity along with molecular disruption of spinal GABAergic system in rats. The present study investigates whether these molecular changes affect the integrative function and responses of bladder-sensitive primary afferent and spinal neurons...
January 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/28125844/proteomic-analysis-of-the-bovine-and-human-ciliary-zonule
#14
Alicia De Maria, Phillip A Wilmarth, Larry L David, Steven Bassnett
Purpose: The zonule of Zinn (ciliary zonule) is a system of fibers that centers the crystalline lens on the optical axis of the eye. Mutations in zonule components underlie syndromic conditions associated with a broad range of ocular pathologies, including microspherophakia and ectopia lentis. Here, we used HPLC-mass spectrometry to determine the molecular composition of the zonule. Methods: Tryptic digests of human and bovine zonular samples were analyzed by HPLC-mass spectrometry...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28116654/autonomic-neuropathy-in-its-many-guises-as-the-initial-manifestation-of-the-antiphospholipid-syndrome
#15
Jill R Schofield
Autonomic disorders have previously been described in association with the antiphospholipid syndrome. The present study aimed to determine the clinical phenotype of patients in whom autonomic dysfunction was the initial manifestation of the antiphospholipid syndrome and to evaluate for autonomic neuropathy in these patients. This was a retrospective study of 22 patients evaluated at the University of Colorado who were found to have a disorder of the autonomic nervous system as the initial manifestation of antiphospholipid syndrome...
January 24, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28110300/irritable-bowel-syndrome-and-diet
#16
REVIEW
Piero Portincasa, Leonilde Bonfrate, Ornella de Bari, Anthony Lembo, Sarah Ballou
Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract and is one of the most commonly diagnosed gastrointestinal diseases. The impact of IBS on the general population is large due to its high prevalence, suboptimal medical treatments and significant economic burden. The pathophysiology of IBS is complex and treatments are often symptom-specific. The most common therapeutic approaches for IBS include education and reassurance, lifestyles (especially nutrition-based interventions), peripherally acting medications (which typically target motility), centrally acting medications (which target visceral hypersensitivity and pain) and psychological interventions (which aim to reduce the effects of stress or symptom-specific anxiety)...
January 20, 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/28104751/exercise-training-decreases-nadph-oxidase-activity-and-restores-skeletal-muscle-mass-in-heart-failure-rats
#17
Telma F Cunha, Luiz Roberto Grassman Bechara, Aline V N Bacurau, Paulo R Jannig, Vanessa Azevedo Voltarelli, Paulo M Dourado, Andrea R Vasconcelos, Cristóforo Scavone, Julio C B Ferreira, Patricia C Brum
We have recently demonstrated that NADPH oxidase hyperactivity, NF-κB activation and increased p38 phosphorylation lead to atrophy of glycolytic muscle in heart failure (HF). Aerobic exercise training (AET) is an efficient strategy to counteract skeletal muscle atrophy in this syndrome. Therefore, we tested whether AET would regulate muscle redox balance and protein degradation by decreasing NADPH oxidase hyperactivity, reestablishing NF-κB signaling, p38 phosphorylation and proteasome activity in plantaris muscle of myocardial infarcted-induced HF (MI) rats...
January 19, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28098913/diets-link-metabolic-syndrome-and-colorectal-cancer-development-review
#18
Jirakrit Saetang, Surasak Sangkhathat
Diets have been believed to be an important factor in the development of metabolic syndrome and colorectal cancer (CRC). In recent years, many studies have shown an intimate relationship between mucosal immunity, metabolism and diets, which has led to a greater understanding of the pathophysiology of metabolic syndrome and CRC development. Although the precise effects of diets on oncogenesis have not been compl-etely elucidated, microbiota changes and inflammation are believed to be important factors that influence the development of CRC...
January 18, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28095089/comparative-data-on-sd-oct-for-the-retinal-nerve-fiber-layer-and-retinal-macular-thickness-in-a-large-cohort-with-marfan-syndrome
#19
WanWan Xu, Sudhi P Kurup, Amani A Fawzi, Mary K Durbin, Irene H Maumenee, Marilyn B Mets
PURPOSE: To report the distribution of macular and optic nerve topography in the eyes of individuals with Marfan syndrome aged 8-56 years using spectral domain optical coherence tomography (SD-OCT). METHODS: Thirty-three patients with Marfan syndrome underwent a full eye examination including slit-lamp biomicroscopy, indirect ophthalmoscopy, and axial length measurement; and SD-OCT measurements of the retinal nerve fiber layer (RNFL) and macular thickness. RESULTS: For patients between the ages of 8 and 12 years, the average RNFL thickness is 98 ± 9 μm, the vertical cup to disc (C:D) ratio is 0...
January 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28093780/subacute-demyelinating-polyradiculoneuropathy-complicating-epstein-barr-virus-infection-in-gata2-haploinsufficiency
#20
Mohamed Kazamel, Christopher J Klein, Eduardo E Benarroch, Mrinal M Patnaik, Jennifer A Tracy
INTRODUCTION: Autosomal dominant haploinsufficiency of GATA2 causes monocytopenia and natural killer cell lymphopenia, resulting in predisposition to mycobacterial, fungal, and viral infections. METHODS: We report clinical, serologic, electrophysiologic, and pathologic evaluation of a 29-year-old woman with GATA2 haploinsufficiency and active Epstein-Barr virus (EBV) infection complicated by subacute painful neuropathy. RESULTS: Nerve conduction and electromyography studies showed predominantly demyelinating sensorimotor polyradiculoneuropathy...
January 17, 2017: Muscle & Nerve
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