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Mucinous breast cancer

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https://www.readbyqxmd.com/read/29339079/diagnostic-usefulness-of-combination-of-diffusion-weighted-imaging-and-t2wi-including-apparent-diffusion-coefficient-in-breast-lesions-assessment-of-histologic-grade
#1
Keum Won Kim, Cherie M Kuzmiak, Young Joong Kim, Jae Young Seo, Hae Kyoung Jung, Mu-Sik Lee
PURPOSE: This study aimed to compare the diagnostic values of a combination of diffusion-weighted imaging and T2-weighted imaging (DWI-T2WI) with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and to evaluate the correlation of DWI with the histologic grade in breast cancer. MATERIALS AND METHODS: This study evaluated a total of 169 breast lesions from 136 patients who underwent both DCE-MRI and DWI (b value, 1000s/mm2). Morphologic and kinetic analyses for DCE-MRI were classified according to the Breast Imaging-Reporting and Data System...
January 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29322114/characteristics-of-special-type-breast-tumors-in-our-center
#2
Tonguç Utku Yılmaz, Levent Trabzonlu, Sertaç Ata Güler, Mehmet Ali Baran, Gökhan Pösteki, Cengiz Erçin, Zafer Utkan
Objective: Breast cancer is a heterogeneous disease with different histological types. Ductal breast cancer constitutes the vast majority of the breast cancers. However limited data are present in the rest of breast cancers called special or rare type breast cancers. Here in this study, we tried to describe the clinical features of special type breast cancers in our center. Materials and Methods: Retrospective descriptive study was performed in Kocaeli University School of Medicine, Department of General Surgery between January 2000 and January 2016...
January 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29321669/phenotypic-characteristics-of-colorectal-cancer-in-brca1-2-mutation-carriers
#3
Albert Grinshpun, Naama Halpern, Roy Zvi Granit, Ayala Hubert, Tamar Hamburger, Yael Laitman, Einat Shacham-Shmueli, Yehudit Peerless, Eitan Friedman, Tamar Peretz
Mutations in the BRCA1/2 genes were recently shown to be associated with an increased risk for colorectal cancer. We characterized the largest cohort available of BRCA1/2 mutation carriers with colorectal cancer. We analyzed 32 patients with lower gastrointestinal cancers and germline BRCA1/2 mutations from two large academic hospital registries; 91% of patients were of Ashkenazi ancestry, 78% were women, and 62.5% were carriers of BRCA1 gene mutations. A high percentage of colorectal tumors (34.5%) had a mucinous histology and were located atypically in the left colon...
January 10, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29291541/her-2-positive-mucinous-carcinoma-breast-cancer-case-report
#4
Irean Garcia Hernandez, Mauricio Canavati Marcos, Margarita Garza Montemayor, Dulce Lopez Sotomayor, Diana Pineda Ochoa, Gabriela Sofia Gomez Macias
INTRODUCTION: Mucinous carcinoma is a variant of invasive breast carcinomas that accounts for 2% of them and has a better prognosis in contrast to the non-specific invasive carcinoma. They regularly are positive for estrogen and progesterone receptors and, generally, they do not overexpress HER2. When HER2 is positive, the first line treatment is trastuzumab; although the resistance is 52-89% for the non-specific carcinoma, it has been described just once in mucinous carcinoma. CASE SUMMARY: A 48-year-old female presented with a lump in her right breast and after a biopsy, it was diagnosed as mucinous carcinoma in the core biopsy and surgical resection, with positive hormone receptors and HER2 positive (3+) in 100% of the tumor cells...
December 26, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29281999/invasive-micropapillary-carcinoma-of-the-breast-overexpresses-muc4-and-is-associated-with-poor-outcome-to-adjuvant-trastuzumab-in-her2-positive-breast-cancer
#5
María F Mercogliano, Gloria Inurrigarro, Mara De Martino, Leandro Venturutti, Martín A Rivas, Rosalía Cordo-Russo, Cecilia J Proietti, Elmer A Fernández, Isabel Frahm, Sabrina Barchuk, Daniel H Allemand, Silvina Figurelli, Ernesto Gil Deza, Sandra Ares, Felipe G Gercovich, Eduardo Cortese, Matías Amasino, Pablo Guzmán, Juan C Roa, Patricia V Elizalde, Roxana Schillaci
BACKGROUND: Invasive micropapillary carcinoma of the breast (IMPC) is a histological tumor variant that occurs with low frequency characterized by an inside-out formation of tumor clusters with a pseudopapillary arrangement. IMPC is an aggressive tumor with poor clinical outcome. In addition, this histological subtype usually expresses human epidermal growth factor receptor 2 (HER2) which also correlates with a more aggressive tumor. In this work we studied the clinical significance of IMPC in HER2-positive breast cancer patients treated with adjuvant trastuzumab...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29279706/metachronous-and-synchronous-occurrence-of-5-primary-malignancies-in-a-female-patient-between-1997-and-2013-a-case-report-with-germline-and-somatic-genetic-analysis
#6
Jenny Nyqvist, Fredrik Persson, Toshima Z Parris, Khalil Helou, Elisabeth Kenne Sarenmalm, Zakaria Einbeigi, Åke Borg, Per Karlsson, Anikó Kovács
The number of patients with multiple primary malignancies has been increasing steadily in recent years. In the present study, we describe a unique case of an 81-year-old woman with 5 metachronous and synchronous primary malignant neoplasms. The patient was first diagnosed with an endometrium adenocarcinoma in 1997 and a colon adenocarcinoma in 2002. Eleven years after her colon surgery, in 2013, the patient presented with 3 other primary malignancies within a 4-month time span: an invasive malignant melanoma on the lower leg, an invasive mucinous breast carcinoma in the right breast, and a pleomorphic spindle cell sarcoma on the left upper arm...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29229020/normalization-of-elevated-tumor-marker-ca27-29-after-bilateral-lung-transplantation-in-a-patient-with-breast-cancer-and-idiopathic-pulmonary-fibrosis
#7
Mehmet Sitki Copur, Julie Marie Wurdeman, Debra Nelson, Ryan Ramaekers, Dron Gauchan, David Crockett
Solid tumors involving glandular organs express mucin glycoprotein which is eventually shed into the circulation. As aresult these proteins can easily be measured in the serum and be used as potential tumor markers. The most commonly used tumor markers for breast cancer are CA 27-29 and CA 15-3, which both measure the glycoprotein product of the mucin-1 (MUC1) gene. CA 27-29 has been approved by the US Food and Drug Administration for monitoring disease activity in breast cancer patients. Most oncology clinical practice guidelines do not recommend the use of tumor markers for routine surveillance of early stage disease but recognize their utility in the metastatic setting...
December 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/29220097/invasive-mucinous-carcinoma-of-the-breast-and-response-patterns-after-neoadjuvant-chemotherapy-nac
#8
Susan Fineberg, Rosemarie Didonato, Nella Shapiro, Tova Koenigsberg, Timothy D'Alfonso, Shabnam Jaffer
AIMS: Neoadjuvant chemotherapy (NAC) is often used to treat localized invasive breast cancer. Invasive mucinous carcinoma (IMC) is considered to be an indolent form of invasive breast cancer and is rarely treated with NAC. We report the largest series of IMC treated with NAC, and report a characteristic, but not well recognized, pattern of pathologic response. METHODS AND RESULTS: Our series included 7 patients with IMC treated with NAC. Three patients presented with locally advanced disease, three patients had tumors that were Her/2Neu positive, and four patients had tumors with admixed mucinous and micropapillary features...
December 8, 2017: Histopathology
https://www.readbyqxmd.com/read/29207126/melatonin-enhances-the-apoptotic-effects-and-modulates-the-changes-in-gene-expression-induced-by-docetaxel-in-mcf%C3%A2-7-human-breast-cancer-cells
#9
Carolina Alonso-González, Javier Menéndez-Menéndez, Alicia González-González, Alicia González, Samuel Cos, Carlos Martínez-Campa
Results from clinical trials and multiple in vivo and in vitro studies point to melatonin as a promising adjuvant molecule with many beneficial effects when concomitantly administered with chemotherapy. Melatonin palliates side‑effects and enhances the efficacy of chemotherapeutic agents. However, the mechanisms through which melatonin regulates molecular changes induced by chemotherapeutic agents remain largely unknown. In this study, we demonstrated that melatonin enhanced the anti-proliferative and apoptotic responses to low doses of docetaxel in breast cancer cells...
November 28, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29202609/the-ability-of-pam50-risk-of-recurrence-score-to-predict-10-year-distant-recurrence-in-hormone-receptor-positive-postmenopausal-women-with-special-histological-subtypes
#10
Anne-Vibeke Laenkholm, Maj-Britt Jensen, Jens Ole Eriksen, Wesley Buckingham, Sean Ferree, Torsten O Nielsen, Bent Ejlertsen
INTRODUCTION: The Prosigna-PAM50 risk of recurrence (ROR) score has been validated in randomized clinical trials to predict 10-year distant recurrence (DR) in hormone receptor-positive breast cancer. Here, we examine the ability of Prosigna for predicting DR at 10 years in a subgroup of postmenopausal breast cancer patients with special histological subtypes. METHODS: Using the population based Danish Breast Cancer Group database, follow-up data were collected on all patients diagnosed from 2000 to 2003 with estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2) normal breast cancer who by nationwide guidelines were treated with 5 year of endocrine therapy (N = 2558)...
January 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29130389/anti-cancer-effects-of-f16-a-novel-vascular-endothelial-growth-factor-receptor-specific-inhibitor
#11
Appu Rathinavelu, Khalid Alhazzani, Sivanesan Dhandayuthapani, Thanigaivelan Kanagasabai
Vascular endothelial growth factor receptor-2 is a dynamic target for therapeutic intervention in various types of cancers. This study was aimed to explore the anti-angiogenic activity of a novel vascular endothelial growth factor receptor-specific inhibitor named F16 in both in vitro and in vivo experimental models. This compound effectively reduced cell proliferation, tube formation, and migration of human umbilical vein endothelial cells in a concentration-dependent manner by directly inhibiting vascular endothelial growth factor binding and subsequent vascular endothelial growth factor receptor-2 phosphorylation...
November 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29121911/immunohistochemical-staining-of-leptin-is-associated-with-grade-stage-lymph-node-involvement-recurrence-and-hormone-receptor-phenotypes-in-breast-cancer
#12
Mohamad Nidal Khabaz, Amer Abdelrahman, Nadeem Butt, Lila Damnhory, Mohamed Elshal, Alia M Aldahlawi, Swsan Ashoor, Basim Al-Maghrabi, Pauline Dobson, Barry Brown, Kaltoom Al-Sakkaf, Mohmmad Al-Qahtani, Jaudah Al-Maghrabi
BACKGROUND: Obesity is part of the established risk factors for breast cancer (BC) in postmenopausal females. Circulating leptin increases in parallel with the increase of body weight and fat reservoir. METHODS: This research investigated the link between leptin phenotype and the clinicopathological factors in BC. A large set of breast cancer cases (449), and 27 non-cancerous tissue samples of breast were employed for leptin expression recognition using immunohistochemistry staining...
November 9, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29119232/histopathological-markers-of-treatment-response-and-recurrence-risk-in-ovarian-cancers-and-borderline-tumors
#13
REVIEW
S Avril
Histopathology plays an important role in defining response to treatment for different tumor types. Histopathologic response criteria are currently used as reference standard in various types of cancer, including breast cancer, gastroesophageal cancer, and bone tumors. Since there were no generally accepted response criteria established for ovarian cancer, a systematic analysis of various features of tumor regression was performed. Patient survival served as the reference standard to validate the histopathologic features of tumor regression...
November 8, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29074302/endogenous-antibody-responses-to-mucin-1-in-a-large-multiethnic-cohort-of-patients-with-breast-cancer-and-healthy-controls-role-of-immunoglobulin-and-fc%C3%AE-receptor-genes
#14
Janardan P Pandey, Aryan M Namboodiri, Bethany Wolf, Motoki Iwasaki, Yoshio Kasuga, Gerson S Hamada, Shoichiro Tsugane
High levels of naturally occurring IgG antibodies to mucin 1 (MUC1), a membrane-bound glycoprotein that is overexpressed in patients with breast cancer, are associated with good prognosis. This suggests that endogenous anti-MUC1 antibodies have a protective effect and, through antibody-mediated host immunosurveillance mechanisms, might contribute to a cancer-free state. To test this possibility, we characterized a large number of multiethnic patients with breast cancer and matched controls for IgG antibodies to MUC1...
February 2018: Immunobiology
https://www.readbyqxmd.com/read/29066614/targeting-the-stat6-pathway-in-tumor-associated-macrophages-reduces-tumor-growth-and-metastatic-niche-formation-in-breast-cancer
#15
Karin Binnemars-Postma, Ruchi Bansal, Gert Storm, Jai Prakash
Tumor-associated macrophages (TAMs) are the key effector cells in the tumor microenvironment and induce neoangiogenesis, matrix remodeling, and metastasis while suppressing the tumor immune system. These protumoral macrophages display an M2 phenotype induced by IL-4 and IL-13 cytokines. In this study, we hypothesized that the inhibition of the signal transducer and activator of transcription 6 (Stat6) pathway, a common downstream signaling pathway of IL-4 and IL-13, may be an interesting strategy by which to inhibit TAM differentiation and, thus, their protumorigenic activities...
October 24, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29063656/micropapillary-variant-of-mucinous-breast-carcinoma-a%C3%A2-distinct-subtype
#16
Katrina Collins, Andrew Ricci
Invasive micropapillary carcinoma of the breast is a subtype with high malignant potential characterized by lymphovascular invasion (LVI) and a predilection for axillary lymph node (AXLN) metastases. In contrast, pure mucinous breast carcinoma (MBC) is relatively indolent with low metastatic potential. Recent studies have described a histologic variant of breast cancer that displays combined mucinous and micropapillary patterns, ie, micropapillary variant of mucinous carcinoma (MpVMBC). This underrecognized variant is, as yet, incompletely characterized clinicopathologically...
October 24, 2017: Breast Journal
https://www.readbyqxmd.com/read/29046794/palliative-surgery-for-giant-mucinous-carcinoma-of-the-breast-in-an-elderly-patient-a-rare-case-report
#17
Haruko Takuwa, Wakako Tsuji, Fumiaki Yotsumoto
Mucinous breast carcinoma (MBC) is relatively rare, accounting for <10% of all breast cancers in women. These tumors are usually slow-growing and exhibit less aggressive characteristics compared with other types of breast cancer. Between 1989 and 2016, 55 patients underwent surgery for MBC at the Shiga Medical Center for Adults (Moriyama, Japan). The 10-year disease-free survival (DFS) and overall survival rates were 94.5 and 100.0%, respectively. Specifically, the 10-year DFS rates of pure MBC (PMBC) and mixed MBC were 97...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29045292/ovarian-metastases-of-breast-cancers-with-signet-ring-cells-a-report-of-17-cases-including-14-krukenberg-tumors
#18
Jennifer A Bennett, Robert H Young, Ai-Ying Chuang, Melinda F Lerwill
Krukenberg tumor, defined as metastatic adenocarcinoma to the ovary containing at least 10% signet ring cells, usually arises from the stomach but can also originate from other sites. We reviewed 17 metastatic breast carcinomas to the ovary with signet ring cells to potentially identify features indicative of mammary origin as opposed to other possible primary sites. The patients ranged from 41 to 76 (mean, 53.6) yr. Fourteen had a prior history of invasive breast carcinoma (invasive ductal carcinoma, 4; invasive lobular carcinoma, 3; adenocarcinoma not otherwise specified, 3; carcinoma with ductal and lobular features, 2; and unspecified carcinoma, 2) and metastases were identified 2 to 284 (mean, 79) mo after the original diagnosis...
October 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29042925/calreticulin-is-an-effective-immunologic-adjuvant-to-tumor-associated-antigens
#19
Jun Wang, Zhi Peng Gao, Song Qin, Chang Bai Liu, Li Li Zou
As a key molecule involved in cell recognition, calreticulin (CRT) may be expressed on the surface of (pre-) apoptotic cells and provide the signal that is recognized by dendritic cells (DCs) or other antigen presenting cells (APCs), which results in phagocytosis. Within the APCs, tumor-associated antigens (TAAs) may be subsequently presented to T lymphocytes, which triggers a specific antitumor immune response. It has been hypothesized that CRT is able to act as the immunologic adjuvant and translocate itself and TAAs to the cell surface and induce a specific antitumor immune response...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29024198/mucocele-like-lesions-diagnosed-on-breast-core-biopsy-low-risk-of-upgrade-and-subsequent-carcinoma
#20
Gloria Zhang, Dana Ataya, Paulette L Lebda, Benjamin C Calhoun
Mucocele-like lesions of the breast diagnosed on core biopsy are usually excised to exclude the possibility of partial sampling of an invasive mucinous carcinoma. The goal of this study was to correlate the pathologic and radiologic features of mucocele-like lesions to determine if excision is mandatory. Over a 16 year period we identified 32 patients with mucocele-like lesions diagnosed on 27 (84%) stereotactic and 5 (16%) ultrasound-guided core biopsies. The indications for core biopsy were: calcifications in 24 (75%), a mass in 7 (22%), and a mass with calcifications in 1 (3%)...
October 11, 2017: Breast Journal
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