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soft tissue tumors diagnosis

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https://www.readbyqxmd.com/read/28634560/atypical-lipomatous-tumor-well-differentiated-liposarcoma-developed-in-a-patient-with-progressive-muscular-dystrophy-a-case-report-and-review-of-the-literature
#1
Ryo Miyagi, Toshihiko Nishisho, Shinjiro Takata, Yoshimitsu Shimatani, Shunichi Toki, Koichi Sairyo
BACKGROUND: Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) is an intermediate or locally aggressive form of adipocytic soft tissue sarcoma. Muscular dystrophy (MD) is characterized by progressive muscle atrophy and its replacement by adipose and fibrous tissue. Recently, some authors have reported that MD genes are related to neoplastic formation, but there have been no detailed clinical reports of ALT associated with MD. CASE PRESENTATION: A 73-year-old woman with a diagnosis of limb-girdle MD visited our department for recurrence of a huge tumor in her left thigh...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28632567/transducing-like-enhancer-of-split-1-a-potential-immunohistochemical-marker-for-glomus-tumor
#2
Nazan Bozdogan, Gulay B Dilek, Emine Benzer, Mujde Karadeniz, Onder Bozdogan
Glomus tumors (GTs) are rare, perivascular soft tissue tumors. Although GTs are usually found in the subcutaneous tissue, they may be detected in extracutaneous sites and mucosal areas. Transducing-like enhancer of split 1 (TLE1) is a highly useful immunohistochemical marker, which basically helps in differential diagnosis of synovial sarcoma. Based on a coincidental detection of TLE1 in one GT case, we studied 26 additional GT cases to establish the importance and distribution of TLE1 in GTs. Of 24 subcutaneous GTs, 22 (91...
July 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28614212/phosphaturic-mesenchymal-tumors-clinicopathologic-immunohistochemical-and-molecular-analysis-of-22-cases-expanding-their-morphologic-and-immunophenotypic-spectrum
#3
Abbas Agaimy, Michael Michal, Simion Chiosea, Fredrik Petersson, Ladislav Hadravsky, Glenn Kristiansen, Raymund E Horch, Jan Schmolders, Arndt Hartmann, Florian Haller, Michal Michal
Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm of uncertain histogenesis that has been linked to tumor-induced osteomalacia (TIO) since 1959. The neoplastic cells produce increased amount of FGF23 which results in TIO via uncontrolled renal loss of phosphate (phosphaturia), and consequently diminished bone mineralization. To date, ∼300 cases have been reported. Although there is increasing evidence that PMT can be diagnosed by reproducible histopathologic features, firm diagnosis has been often restricted to cases associated with TIO and, hence, diagnosis of "nonphosphaturic variants" remained challenging...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28607790/sporadic-retroperitoneal-hemangioblastoma-report-of-a-case-and-review-of-the-literature
#4
F G Jalikis, B L Hoch, R Bakthavatsalam, M I Montenovo
We report a case of sporadic isolated hemangioblastoma arising from the retroperitoneum and provide a review of the scarce literature regarding this very rare tumor. Furthermore, we thoroughly describe the pathologic features and the broad differential diagnosis that should always be included in the study of any retroperitoneal soft tissue mass to arrive at the final diagnosis.
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28607608/clinical-features-pathological-findings-and-treatment-of-recurrent-dermatofibrosarcoma-protuberans
#5
Yanan Li, Chuan Wang, Bo Xiang, Siyuan Chen, Li Li, Yi Ji
Dermatofibrosarcoma protuberans (DESP) is a relatively rare and low-grade tumor of the skin and soft tissue. We review the clinical features, pathological findings and management of recurrent DESP with the aim to improve our understanding of this rare tumor. Fifty-seven patients were diagnosed with recurrent DFSP. The mean age at the presentation of DFSP was 30.9 years. The mean age at diagnosis of DFSP was 40.2 years. Chest wall was the dominant location. The histopathological diagnosis was ordinary DFSP (O-DFSP) in 46 cases and fibrosarcomatous DFSP (FS-DFSP) in 11 cases...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28606791/chondrolipoma-of-the-ankle-in-a-child-a-case-report
#6
Takuya Ishibashi, Jun Nishio, Shunsuke Kobayashi, Kei Shiramizu, Takuaki Yamamoto
Chondrolipoma is an extremely rare variant of lipoma with cartilaginous metaplasia. The presence of nonlipomatous components can lead to a variety of entities in the differential diagnosis from the radiologic findings. We describe an unusual case of a chondrolipoma occurring in the right ankle of a 9-year-old female. Physical examination showed a 3.5-cm, elastic-hard, poorly mobile, nontender mass adherent to the Achilles tendon. Plain radiographs revealed a faintly calcified soft tissue mass without bone involvement...
June 9, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28601660/smarca4-deficient-thoracic-sarcoma-report-of-a-case-and-insights-into-how-to-reach-the-diagnosis-using-limited-samples-and-resources
#7
Satoshi Kuwamoto, Michiko Matsushita, Kenichi Takeda, Natsumi Tanaka, Yukari Endo, Akira Yamasaki, Kenichi Kohashi, Yoshinao Oda, Yasushi Horie
SMARCA4-deficient thoracic sarcoma is a recently proposed new entity of soft tissue sarcomas with an undifferentiated round cell morphology that is diagnostically challenging. Here we report a case of this tumor where the diagnosis was established using limited samples and resources. A woman in her early 30s developed two intrathoracic masses. Biopsies for these lesions showed sheets of undifferentiated round/rhabdoid cells that retained SMARCB1 expression. Further analysis revealed a reduced SMARCA4 expression and a complete loss of SMARCA2 expression in tumor cells...
June 7, 2017: Human Pathology
https://www.readbyqxmd.com/read/28601297/outcomes-of-multimodal-management-for-sinonasal-squamous-cell-carcinoma
#8
Arnaud Paré, Pierre Blanchard, Silvia Rosellini, Anne Aupérin, Philippe Gorphe, Odile Casiraghi, Stéphane Temam, François Bidault, Philippe Page, Frédéric Kolb, François Janot, Antoine Moya Plana
BACKGROUND: Poor prognosis of sinonasal cancers (SNC) is usually due to the non-specific symptoms leading to late diagnosis with locally advanced disease. However, previous prognostic studies were often based on heterogeneous cohorts because of the scarcity of SNC. With squamous cell carcinoma being the main histological subgroup, the study aimed to perform a prognostic analysis on sinonasal squamous cell carcinoma (SNSCC) particularly, and to evaluate the oncological results of a multimodal therapy...
May 12, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28599446/giant-cell-tumor-of-the-tendon-sheath-magnetic-resonance-imaging-findings-in-38-patients
#9
Chao Wang, Rui-Rui Song, Ping-Ding Kuang, Liu-Hong Wang, Min-Ming Zhang
The present study aimed to investigate the value of magnetic resonance imaging (MRI) in the diagnosis of giant cell tumor of the tendon sheath (GCTTS), including localized (L-) and diffuse (D-) types. A total of 38 patients with GCTTS, including 31 with L-GCTTS and 7 with D-GCTTS, diagnosed by surgery and pathology, were retrospectively analyzed. All patients underwent MRI examination. Of the 31 patients with L-GCTTS, the tumors were located in the hand and wrist (18 patients), the ankle and foot (10 cases), the knee joint (2 cases) and the temporomandibular joint (1 case)...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28597669/-myxoid-tumors-of-soft-tissues
#10
Karel Veselý
Myxoid tumours of soft tissue represent a heterogeneous spectrum of lesions with variable biological behaviour, from completely benign to highly aggressive malignancies. Myxoid tumours share abundant myxoid extracellular matrix, overlapping histopathologic features and immunohistochemical findings, with resulting diagnostic problems. This review article attempts to give the most complete list possible, with the characterization of gross and microscopic features, relevant immunohistochemical and molecular biology findings and to outline differential diagnosis...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28596939/undifferentiated-pleomorphic-sarcoma-and-the-importance-of-considering-the-oncogenic-and-immune-suppressant-role-of-the-human-t-cell-lymphotropic-virus-type-1-a-case-report
#11
Sergio Lupo, Carolina Berini, Camila Cánepa, Eduardo Santini Araujo, Mirna Biglione
INTRODUCTION: Soft-tissue sarcomas account for 0.7% of all malignant tumors, with an incidence rate of 3 per 100,000 persons/year. The undifferentiated pleomorphic sarcoma (UPS) with giant cells, a high grade tumor of soft tissue, is very unusual, especially in young adults before the age of 40. Human T-cell lymphotropic virus type 1 (HTLV-1) is a human retrovirus, classified as group 1 human carcinogens by The International Agency for Research on Cancer, that causes an aggressive malignancy known as adult T-cell lymphoma/leukemia and a progressive chronic inflammatory neurological disease named HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28594943/childhood-cancer-risk-in-those-with-chromosomal-and-non-chromosomal-congenital-anomalies-in-washington-state-1984-2013
#12
Marlena S Norwood, Philip J Lupo, Eric J Chow, Michael E Scheurer, Sharon E Plon, Heather E Danysh, Logan G Spector, Susan E Carozza, David R Doody, Beth A Mueller
BACKGROUND: The presence of a congenital anomaly is associated with increased childhood cancer risk, likely due to large effects of Down syndrome and chromosomal anomalies for leukemia. Less is known about associations with presence of non-chromosomal anomalies. METHODS: Records of children diagnosed with cancer at <20 years of age during 1984-2013 in Washington State cancer registries were linked to their birth certificates (N = 4,105). A comparison group of children born in the same years was identified...
2017: PloS One
https://www.readbyqxmd.com/read/28594531/soft-tissue-tumors-a-pictorial-and-case-based-guide-to-diagnosis-and-management
#13
Valerae O Lewis, Adam S Levin, Ginger E Holt, Timothy A Damron, Scott D Weiner, Carol D Morris
General orthopaedic surgeons must learn how to appropriately evaluate patients with soft-tissue masses who present at their office. Although the incidence of benign soft-tissue sarcomas substantially outnumbers that of malignant soft-tissue sarcomas, the mismanagement of soft-tissue tumors markedly increases a patient's morbidity. The appropriate use of imaging modalities helps general orthopaedic surgeons accurately diagnose a soft-tissue mass, initiate appropriate management of a soft-tissue mass, and gain a better understanding of which patients with soft-tissue lesions should be referred to an orthopaedic oncologist...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28593381/paraspinal-hibernoma-grand-round-presentation-of-a-rare-benign-adipocytic-tumor
#14
Soufiane Ghailane, Houssam Bouloussa, Sandra Fauquier, Caroline Ziadé, Olivier Gille
INTRODUCTION: We report an uncommon case of paraspinal hibernoma with a T12-L1 foraminal extension and discuss the potential differential diagnoses of paraspinal adipocytic tumors. MATERIALS AND METHODS: A 32-year-old woman consulted our department with a right subscapular and paraspinal mass. There was no associated neurological deficit. The MRI revealed a paraspinal adipocytic tumor with a T12-L1 right foraminal extension. Percutaneous biopsy suggested a diagnosis of hibernoma...
June 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28592757/hiv-negative-plasmablastic-lymphoma-attaining-sustained-remission-with-bortezomib-combined-dose-adjusted-epoch-therapy
#15
Hiroyuki Kobayashi, Norito Miyagi
A 61-year-old, HIV-negative, immunocompetent woman was admitted to our hospital for significant weight loss, painful swelling of her right cheek, and rapid growth of a tumor in the right hard palate. A CT scan revealed a neoplastic lesion in the right maxillary sinus, extending to the surrounding soft bone tissue and oral cavity, as well as multiple osteolytic lesions in the skull. A pathologic examination revealed that the neoplastic cells in the oral cavity were plasmablasts tending to appear as differentiated plasma cells...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28591457/cutaneous-sarcomas
#16
Judith Kohlmeyer, Susanne Annette Steimle-Grauer, Rüdiger Hein
Cutaneous sarcomas comprise a heterogeneous group of mesenchymal spindle cell tumors of the dermis and subcutis, one of the best-known entities being dermatofibrosarcoma protuberans. Other sarcomas addressed in this review include atypical fibroxanthoma, cutaneous undifferentiated pleomorphic sarcoma, leiomyosarcoma, liposarcoma, and angiosarcoma. With the exception of dermatofibrosarcoma protuberans, which has its peak incidence in middle-aged adults, cutaneous sarcomas usually occur in elderly individuals starting in the sixth or seventh decade of life...
June 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28591446/kutane-sarkome
#17
Judith Kohlmeyer, Susanne Annette Steimle-Grauer, Rüdiger Hein
Cutaneous sarcomas comprise a heterogeneous group of mesenchymal spindle cell tumors of the dermis and subcutis, one of the best-known entities being dermatofibrosarcoma protuberans. Other sarcomas addressed in this review include a typical fibroxanthoma, cutaneous undifferentiated pleomorphic sarcoma, leiomyosarcoma, liposarcoma, and angiosarcoma. With the exception of dermatofibrosarcoma protuberans, which has its peak incidence in middle-aged adults, cutaneous sarcomas usually occur in elderly individuals starting in the sixth or seventh decade of life...
June 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28589437/low-grade-carcinoma-ex-pleomorphic-adenoma-diagnosis-and-diagnostic-challenges-caused-by-fine-needle-aspiration-report-of-three-cases-and-review-of-literature
#18
Michael Covinsky, Zhenjian Cai, Manju Ambelil, Jing Liu, Hui Zhu
Low grade carcinoma ex pleomorphic adenoma (LG CXPA) is a rare low grade malignant neoplasm arising from preexisting pleomorphic adenoma (PA). LG CXPA demonstrates no overt cytological atypia, and can be difficult to distinguish from cellular PA. Invasive growth is one of the hallmarks of LG CXPA, e.g., tumor extends beyond the capsule and into adjacent non-neoplastic tissue. However, it is known that capsular and vascular invasion, as well as the presence of stroma-rich PA in soft tissue without a capsule (pseudopodia) can be seen in PA...
June 6, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28588708/indolent-growth-of-low-grade-myofibroblastic-sarcoma-of-the-cheek-mimics-benign-lesions-a-case-report-and-literature-review
#19
Tessho Maruyama, Toshiyuki Nakasone, Fumikazu Nimura, Akira Matayoshi, Toshihiro Kawano, Kazuhide Nishihara, Akira Arasaki
Low-grade myofibroblastic sarcoma (LGMS) is a neoplasm of the soft tissue characterized by myofibroblastic differentiation. This type of tumor has been observed in various sites in the whole body, but frequently occurs in the head and neck region. It typically presents as a slow-growing painless mass, which is often mistaken for a benign lesion due to its indolent growth; however, LGMS is a malignant neoplasm. In the present study, a 43-year-old female presented with a 14-mm LGMS lesion in the buccal subcutaneous tissues of the buccinator muscle...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28585251/tfe3-rearranged-hepatic-epithelioid-hemangioendothelioma-a-case-report-with-immunohistochemical-and-molecular-study
#20
Fang-Ying Kuo, Hsuan-Ying Huang, Chao-Long Chen, Hock-Liew Eng, Chao-Cheng Huang
A recurrent YAP1-TFE3 gene fusion has been identified in WWTR1-CAMTA1-negative epithelioid hemangioendotheliomas arising in soft tissue, bone, and lung, but not in liver. We present the first case of TFE3-rearranged hepatic epithelioid hemangioendothelioma in a 39-year-old Taiwanese woman. Computed tomography scan revealed multifocal, ill-defined nodules involving both hepatic lobes. She then underwent deceased donor liver transplantation. Histologically, the tumors in the liver explant showed a biphasic growth pattern...
June 6, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
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