Ingegerd Öfverholm, Karin Wallander, Cecilia Haglund, Venkatesh Chellappa, Johan Wejde, Anna Gellerbring, Valtteri Wirta, Annick Renevey, Eva Caceres, Panagiotis Tsagkozis, Markus Mayrhofer, Andri Papakonstantinou, Christina Linder-Stragliotto, Robert Bränström, Olle Larsson, Johan Lindberg, Yingbo Lin, Felix Haglund de Flon
PURPOSE: Tumor classification is a key component in personalized cancer care. For soft tissue and bone tumors, this classification is currently based primarily on morphology assessment and immunohistochemical staining. However, these standard-of-care methods can pose challenges for pathologists. We therefore assessed how whole-genome and whole-transcriptome sequencing (WGTS) impacted tumor classification and clinical management when interpreted together with histomorphology. EXPERIMENTAL DESIGN: We prospectively evaluated WGTS in routine diagnostics of 200 soft tissue and bone tumors suspicious for malignancy, including DNA and RNA isolation from the tumor, and DNA isolation from a peripheral blood sample or any non-tumor tissue...
April 4, 2024: Clinical Cancer Research