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soft tissue classification

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https://www.readbyqxmd.com/read/29775983/classification-and-microvascular-flap-selection-for-anterior-cranial-fossa-reconstruction
#1
James D Vargo, Wojciech Przylecki, Paul J Camarata, Brian T Andrews
BACKGROUND:  Microvascular reconstruction of the anterior cranial fossa (ACF) creates difficult challenges. Reconstructive goals and flap selection vary based on the defect location within the ACF. This study evaluates the feasibility and reliability of free tissue transfer for salvage reconstruction of low, middle, and high ACF defects. METHODS:  A retrospective review was performed. Reconstructions were anatomically classified as low (anterior skull base), middle (frontal bar/sinus), and high (frontal bone/soft tissue)...
May 18, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29768051/the-key-role-of-pathology-surgery-and-radiotherapy-in-the-initial-management-of-soft-tissue-sarcoma
#2
Angelo Paolo Dei Tos, Sylvie Bonvalot, Rick Haas
Soft tissue sarcomas are a heterogeneous group of rare malignancies. The diagnostic gold standard is conventional histomorphology with integrated immunohistochemistry. Molecular genetic profiling has identified new subgroups of undifferentiated sarcomas involving genetic rearrangements with creation of fusion genes. Accurate classification of sarcomas is critical for appropriate clinical decision-making which should involve a multidisciplinary team. A preoperative biopsy is necessary to confirm a diagnosis...
May 2018: Future Oncology
https://www.readbyqxmd.com/read/29758589/spindle-cell-rhabdomyosarcoma-of-bone-with-fus-tfcp2-fusion-confirmation-of-a-very-recently-described-rhabdomyosarcoma-subtype
#3
Nooshin K Dashti, Rebecca N Wehrs, Brittany C Thomas, Asha Nair, Jaime Davila, Jan C Buckner, Anthony P Martinez, William R Sukov, Kevin C Halling, Benjamin M Howe, Andrew L Folpe
AIMS: Rhabdomyosarcomas of bone are extremely rare, with fewer than 10 reported cases. A very rare subtype of spindle cell/sclerosing rhabdomyosarcoma harboring a FUS-TFCP2 fusion and involving both soft tissue and bone locations has very recently been reported. We report only the fourth case of this unusual, clinically aggressive rhabdomyosarcoma. MATERIAL AND RESULTS: A previously-well 72-year old male presented with a destructive lesion of the mandible. Morphological and immunohistochemical study of a needle biopsy and the subsequent resection showed a spindle cell rhabdomyosarcoma...
May 14, 2018: Histopathology
https://www.readbyqxmd.com/read/29748878/clinical-and-radiological-outcome-of-gustilo-type-iii-open-distal-tibial-and-tibial-shaft-fractures-after-staged-treatment-with-posterolateral-minimally-invasive-plate-osteosynthesis-mipo-technique
#4
Xiaojian He, Chuanzhen Hu, Kaihua Zhou, Qilin Zhai, Weifeng Wen, Fugen Pan
OBJECTIVES: To evaluate the methods and the outcomes of Gustilo type III open distal tibial and tibial shaft fractures with severe anterior and medial soft-tissue injuries, treated with posterolateral minimally invasive plate osteosynthesis (MIPO) technique. METHODS: From May 2015 to May 2016, 10 patients with Gustilo type III open distal tibial and tibial shaft fractures with severe anterior and medial soft-tissue injuries (Gustilo-Anderson classification IIIA, 6; IIIB, 4) were treated with staged protocol using posterolateral minimally invasive plate osteosynthesis (MIPO) technique...
May 10, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29740534/genomic-dna-methylation-derived-algorithm-enables-accurate-detection-of-malignant-prostate-tissues
#5
Erfan Aref-Eshghi, Laila C Schenkel, Peter Ainsworth, Hanxin Lin, David I Rodenhiser, Jean-Claude Cutz, Bekim Sadikovic
Introduction: The current methodology involving diagnosis of prostate cancer (PCa) relies on the pathology examination of prostate needle biopsies, a method with high false negative rates partly due to temporospatial, molecular, and morphological heterogeneity of prostate adenocarcinoma. It is postulated that molecular markers have a potential to assign diagnosis to a considerable portion of undetected prostate tumors. This study examines the genome-wide DNA methylation changes in PCa in search of genomic markers for the development of a diagnostic algorithm for PCa screening...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29728955/relationships-among-retropalatal-airway-pharyngeal-length-and-craniofacial-structures-determined-by-magnetic-resonance-imaging-in-patients-with-obstructive-sleep-apnea
#6
Suat Avci, Hatice Lakadamyali, Huseyin Lakadamyali, Erdinc Aydin, Mustafa Agah Tekindal
BACKGROUND: The integration of anatomical and nonanatomical parameters will improve our ability to predict the outcomes of OSA treatment. Currently, no standardized, quantitative classification of upper airway anatomical traits is available. The retropalatal (RP) airway is the most important area to consider when planning anatomical treatment. However, current evaluation methods feature qualitative conventional endoscopy. Here, we describe a quantitative magnetic resonance imaging (MRI) method used to classify RP airway patterns...
May 5, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29708525/establishment-of-a-primary-culture-of-patient-derived-soft-tissue-sarcoma
#7
Alessandro De Vita, Laura Mercatali, Giacomo Miserocchi, Chiara Liverani, Chiara Spadazzi, Federica Recine, Alberto Bongiovanni, Federica Pieri, Davide Cavaliere, Valentina Fausti, Dino Amadori, Toni Ibrahim
Soft tissue sarcomas (STS) represent a spectrum of heterogeneous malignancies with a difficult diagnosis, classification, and management. To date, more than 50 histological subtypes of these rare solid tumors have been identified. Thus, due to their extraordinary diversity and low incidence, our understanding of the biology of these tumors is still limited. Patient-derived cultures represent the ideal platform to study STS pathophysiology and pharmacology. We thus developed a human preclinical model of STS starting from tumor specimens harvested from patients undergoing surgical resection...
April 11, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29706405/detection-of-white-matter-lesion-regions-in-mri-using-slic0-and-convolutional-neural-network
#8
Pedro Henrique Bandeira Diniz, Thales Levi Azevedo Valente, João Otávio Bandeira Diniz, Aristófanes Corrêa Silva, Marcelo Gattass, Nina Ventura, Bernardo Carvalho Muniz, Emerson Leandro Gasparetto
BACKGROUND AND OBJECTIVE: White matter lesions are non-static brain lesions that have a prevalence rate up to 98% in the elderly population. Because they may be associated with several brain diseases, it is important that they are detected as soon as possible. Magnetic Resonance Imaging (MRI) provides three-dimensional data with the possibility to detect and emphasize contrast differences in soft tissues, providing rich information about the human soft tissue anatomy. However, the amount of data provided for these images is far too much for manual analysis/interpretation, representing a difficult and time-consuming task for specialists...
April 19, 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29699827/iatrogenic-bone-and-soft-tissue-trauma-in-robotic-arm-assisted-total-knee-arthroplasty-compared-with-conventional-jig-based-total-knee-arthroplasty-a-prospective-cohort-study-and-validation-of-a-new-classification-system
#9
Babar Kayani, Sujith Konan, Jurek R T Pietrzak, Fares S Haddad
BACKGROUND: The objective of this study was to compare macroscopic bone and soft tissue injury between robotic-arm assisted total knee arthroplasty (RA-TKA) and conventional jig-based total knee arthroplasty (CJ-TKA) and create a validated classification system for reporting iatrogenic bone and periarticular soft tissue injury after TKA. METHODS: This study included 30 consecutive CJ-TKAs followed by 30 consecutive RA-TKAs performed by a single surgeon. Intraoperative photographs of the femur, tibia, and periarticular soft tissues were taken before implantation of prostheses...
March 27, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29696477/imaging-features-of-benign-mass-lesions-in-the-nasal-cavity-and-paranasal-sinuses-according-to-the-2017-who-classification
#10
REVIEW
Hiroyuki Tatekawa, Taro Shimono, Masahiko Ohsawa, Satoshi Doishita, Shinichi Sakamoto, Yukio Miki
The World Health Organization (WHO) 2017 classification of head and neck tumors has been just published and has reorganized tumors of the nasal cavity and paranasal sinuses. In this classification, three new entities (seromucinous hamartoma, NUT carcinoma, and biphenotypic sinonasal sarcoma) were included, while the total number of tumors has been reduced by excluding tumors if they did not occur exclusively or predominantly in this region. Among these entities, benign tumors were classified as sinonasal papillomas, respiratory epithelial lesions, salivary gland tumors, benign soft tissue tumors, or other tumors...
April 25, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29692655/limb-salvage-surgery-of-soft-tissue-sarcoma-with-sciatic-nerve-involvement
#11
Hussein Sweiti, Noor Tamimi, Fabian Bormann, Markus Divo, Daniela Schulz-Ertner, Marit Ahrens, Ulrich Ronellenfitsch, Matthias Schwarzbach
Background: The surgical resection of soft tissue sarcomas (STS) with sciatic nerve involvement presents a significant surgical and oncological challenge. Current treatment strategies pursue a multimodal approach with the aim of limb preservation. We aim to evaluate the outcomes of limb-sparing surgery of STS in a patient cohort and to propose a classification for STS with sciatic nerve involvement. Methods: Patients receiving limb-preserving resections for STS with sciatic nerve involvement between 01/2010 and 01/2017 were included...
2018: Sarcoma
https://www.readbyqxmd.com/read/29687005/medium-long-term-radiographic-and-clinical-outcomes-after-surgical-treatment-of-intra-articular-tibial-pilon-fractures-by-three-different-techniques
#12
Carlo Biz, Andrea Angelini, Marco Zamperetti, Filippo Marzotto, Silvano Pierluigi Sperotto, Diego Carniel, Claudio Iacobellis, Pietro Ruggieri
Introduction: The goal of this retrospective, observational, case series study was to evaluate the medium-long-term clinical and radiographic results of the three most common surgical osteosynthesis techniques used for the treatment of articular tibial pilon fractures: ORIF, MIPO, and EF. Materials and Methods: A consecutive series of patients with articular pilon fractures who underwent surgery at our institution were enrolled in this study. Fractures were classified according to the Müller AO classification system...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29665603/pain-in-osteochondral-lesions-of-the-ankle-an-investigation-based-on-data-from-the-german-cartilage-registry-knorpelregister-dgou
#13
Daniel Körner, Philipp Kohler, Steffen Schröter, Aline Naumann, Markus Walther, Philipp Niemeyer, Yannic Bangert, Matthias Aurich, Atesch Ateschrang
BACKGROUND: The aim of the study was to investigate parameters influencing the preoperative pain intensity in patients with osteochondral lesions of the ankle. The evaluation covered patient-related parameters such as age, sex, body mass index (BMI), as well as defect-related parameters, such as localisation, size and stage (according to the classification of the International Cartilage Repair Society [ICRS] and the Berndt-Harty-Loomer classification). We also examined the correlation between the different surgical techniques and additional factors, such as debridement of an impingement or stabilisation of the ankle on the one hand, and the preoperative pain intensity on the other...
April 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29664881/tibial-fracture-nonunion-and-time-to-healing-following-reamed-intramedullary-nailing-risk-factors-based-on-a-single-centre-review-of-1003-patients
#14
Hannah L Dailey, Katherine A Wu, Ping-Shi Wu, Margaret M McQueen, Charles M Court-Brown
OBJECTIVE: To determine factors associated with nonunion of adult tibial fractures. DESIGN: Retrospective review with data collection for logistic regression and survival analysis. SETTING: Scottish Level I trauma centre, 1985 to 2007. PATIENTS: During this period, 1,590 adult tibial fractures were treated by reamed nailing and 1,003 met all inclusion criteria for the chosen analysis. INTERVENTION: Reamed intramedullary nailing...
April 3, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29660202/molecular-biomarkers-for-uterine-leiomyosarcoma-and-endometrial-stromal-sarcoma
#15
REVIEW
Hideaki Tsuyoshi, Yoshio Yoshida
Uterine leiomyosarcoma (u{\hyphen}LMS) and endometrial stromal sarcoma (ESS) are among the most frequent soft tissue sarcomas, which, in adults, lead to fatal lung metastases and have an extremely poor prognosis. Due to their rarity and heterogeneity, there are no suitable biomarkers for diagnosis and prognosis, though some biomarker candidates have appeared. Recently, The Cancer Genome Atlas (TCGA) projects dealing with u{\hyphen}LMS confirmed mutations and deletions in RB1, TP53, and PTEN. In addition, whole{\hyphen}exome sequencing of u{\hyphen}LMS has confirmed and demonstrated frequent alterations in TP53, RB1, α-thalassemia/mental retardation syndrome X-linked (ATRX), and mediator complex subunit 12 (MED12)...
April 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29658534/the-influence-of-osteoporotic-bone-structures-of-the-pelvic-hip-complex-on-stress-distribution-under-impact-load
#16
Katarzyna Arkusz, Tomasz Klekiel, Niezgoda Niezgoda, Romuald Będziński
PURPOSE: The aim of this study was to determine the effect of bone mineral density (BMD) on the stress distribution in pelvic-hip complex (PHC) model which included bone structures and soft tissues. Bone mass changes in osteoporosis and osteopenia were considered in this analysis. In addition, the relations between force direction and stress distribution causing PHC fractures were determined. METHODS: This paper presents the development and validation of a detailed 3D finite element model with high anatomical fidelity of the PHC and BMD changes in trabecular and cortical bones, modelled based on CT scans...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29626818/rapid-authentication-and-identification-of-different-types-of-a-roxburghii-by-tri-step-ft-ir-spectroscopy
#17
Ying Chen, Jinfang Huang, Zhao Qin Yeap, Xue Zhang, Shuisheng Wu, Chiew Hoong Ng, Mun Fei Yam
Anoectochilus roxburghii (Wall.) Lindl. (Orchidaceae) is a precious traditional Chinese medicinal herb and has been perennially used to treat various illness. However, there were unethical sellers who adulterated wild A. roxburghii with tissue cultured and cultivated ones. Therefore, there is an urgent need for an effective authentication method to differentiate between these different types of A. roxburghii. In this research, the infrared spectroscopic tri-step identification approach including Fourier transform infrared spectroscopy (FT-IR), Second derivative infrared spectra (SD-IR) and two-dimensional correlation infrared spectra (2D-IR) was used to develop a simple and rapid method to discriminate between wild, cultivated and tissue cultivated A...
March 24, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29621244/the-cost-saving-effect-of-centralized-histological-reviews-with-soft-tissue-and-visceral-sarcomas-gist-and-desmoid-tumors-the-experiences-of-the-pathologists-of-the-french-sarcoma-group
#18
Lionel Perrier, Pauline Rascle, Magali Morelle, Maud Toulmonde, Dominique Ranchere Vince, Axel Le Cesne, Philippe Terrier, Agnès Neuville, Pierre Meeus, Fadila Farsi, Françoise Ducimetière, Jean-Yves Blay, Isabelle Ray Coquard, Jean-Michel Coindre
OBJECTIVE: This study examined the types of discordance occurring in the diagnosis of soft tissue and visceral sarcomas, gastrointestinal stromal tumors (GIST), and desmoid tumors, as well as the economic impact of diagnostic discrepancies. METHODS: We carried out a retrospective, multicenter analysis using prospectively implemented databases performed on a cohort of patients within the French RRePS network in 2010. Diagnoses were deemed to be discordant based on the 2013 World Health Organization (WHO) classification...
2018: PloS One
https://www.readbyqxmd.com/read/29611216/a-semiautomatic-segmentation-method-for-prostate-in-ct-images-using-local-texture-classification-and-statistical-shape-modeling
#19
Maysam Shahedi, Martin Halicek, Rongrong Guo, Guoyi Zhang, David S Schuster, Baowei Fei
PURPOSE: Prostate segmentation in computed tomography (CT) images is useful for treatment planning and procedure guidance such as external beam radiotherapy and brachytherapy. However, because of the low, soft tissue contrast of CT images, manual segmentation of the prostate is a time-consuming task with high interobserver variation. In this study, we proposed a semiautomated, three-dimensional (3D) segmentation for prostate CT images using shape and texture analysis and we evaluated the method against manual reference segmentations...
April 2, 2018: Medical Physics
https://www.readbyqxmd.com/read/29598844/effect-of-bmi-on-outcomes-of-surgical-treatment-for-tibial-plateau-fractures-a-comparative-retrospective-case-series-study
#20
Yaşar Mahsut Dinçel, Ali Öner, Yavuz Arikan, Sever Çaglar, Raşit Özcafer, Mehmet Akif Güleç
PURPOSE: Tibia plateau fracture (TPF) treatment aims at achieving a stable, aligned, mobile, painless knee and preventing post-traumatic osteoarthritis. To achieve this goal, surgeons consider criteria such as patients' characteristics, severity, risk of complications, fracture displacement/depression, degree of soft tissue injury. However, body mass index (BMI) is not considered as a risk factor in literature. Our study was conducted to find out any possible correlation between BMI and functional scores or radiological score separately...
March 2, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
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