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https://www.readbyqxmd.com/read/29457437/-clinical-application-value-of-mri-on-malignant-fibrous-histiocytoma-in-soft-tissue
#1
Wan-Li Xu, Xiao Wu, Hai-Feng Qian, Dong Liu
OBJECTIVE: To investigate imaging manifestation and clinical application of MRI on malignant fibrous histiocytoma (MFH) in soft tissue. METHODS: Imaging and pathological data of 16 patients with malignant fibrous histiocytoma (MFH) in soft tissue confirmed by surgery and pathology were retrospectively analyzed from January 2009 to August 2016. There were 9 males and 7 females, aged from 34 to 67 years old with an average of 52 years. The courses of disease ranged from 5 to 48 months with an average of 27 months...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29454285/pou5f1b-promotes-hepatocellular-carcinoma-proliferation-by-activating-akt
#2
Yaozhen Pan, Lei Zhan, Ling Chen, Hong Zhang, Chengyi Sun, Chungen Xing
Hepatocellular carcinoma (HCC) is one of the most common tumors, so far, there still aren't good therapeutic methods. Looking for new targets makes a top priority. In this study, we found a OCT4 pseudogene, POU5F1B was significantly upregulated in HCC cells and tissues, patients with high POU5F1B had shorter survival time compared to patients with low POU5F1B expression. POU5F1B overexpression promoted HCC proliferation, while its knockdown inhibited HCC proliferation determined by MTT assay, soft agar growth assay, BrdU incorporation assay, and cell cycle assay...
February 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29453166/skull-metastasis-revealing-a-renal-tumor-a-case-report-and-review-of-the-literature
#3
Mohamed Badri, Ghassen Gader, Kamel Bahri, Ihsen Zammel
BACKGROUND: Renal cell carcinomas represent 85% of malignant renal tumors. Typically, the tumor remains asymptomatic a long time before the appearance of urologic clinical signs. In some cases, metastasis can precede the manifestations of the primary tumor. Different sites are potential metastatic localizations for renal tumors, including skull metastases who represent a very rare location. CASE DESCRIPTION: We report the case of a 65-year-old man presented after the appearance of a skull mass...
February 10, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29451149/a-study-on-clinical-characteristics-and-magnetic-resonance-imaging-manifestations-on-systemic-rosai-dorfman-disease
#4
Xiao Cheng, Jing-Liang Cheng, An-Kang Gao
Background: Rosai-Dorfman disease (RDD) is typically characterized by painless bilateral and symmetrical cervical lymphadenopathy, with associated fever and leukocytosis. The aim of the current study was to summarize the clinical features and imaging characteristics of RDD, in an effort to improve its diagnostic accuracy. Methods: The study was analyzed from 32 patients between January 2011 and December 2017; of these, 16 patients had pathologically diagnosed RDD, eight had pathologically diagnosed meningioma, and eight pathologically diagnosed lymphoma...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29450452/effect-of-neoadjuvant-chemotherapy-plus-regional-hyperthermia-on-long-term-outcomes-among-patients-with-localized-high-risk-soft-tissue-sarcoma-the-eortc-62961-esho-95-randomized-clinical-trial
#5
Rolf D Issels, Lars H Lindner, Jaap Verweij, Rüdiger Wessalowski, Peter Reichardt, Peter Wust, Pirus Ghadjar, Peter Hohenberger, Martin Angele, Christoph Salat, Zeljko Vujaskovic, Soeren Daugaard, Olav Mella, Ulrich Mansmann, Hans Roland Dürr, Thomas Knösel, Sultan Abdel-Rahman, Michael Schmidt, Wolfgang Hiddemann, Karl-Walter Jauch, Claus Belka, Alessandro Gronchi
Importance: Patients with soft tissue sarcoma are at risk for local recurrence and distant metastases despite optimal local treatment. Preoperative anthracycline plus ifosfamide chemotherapy improves outcome in common histological subtypes. Objective: To analyze whether the previously reported improvement in local progression-free survival by adding regional hyperthermia to neoadjuvant chemotherapy translates into improved survival. Design, Setting, and Participants: Open-label, phase 3 randomized clinical trial to evaluate the efficacy and toxic effects of neoadjuvant chemotherapy plus regional hyperthermia...
February 15, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29446979/synovial-sarcoma-mimicking-a-thoracic-dumbell-schwannoma-a-case-report
#6
Susanth Subramanian, Gandham Edmond Jonathan, Bimal Patel, Krishna Prabhu
INTRODUCTION: Synovial sarcoma is a rare mesenchymal malignant neoplasm that accounts for less than 10% of soft tissue sarcomas. About 95% of the sarcomas occur in the extremities. Primary synovial sarcomas of the spine are a rare tumor arising from the paravertebral regions, paraspinal muscles or epidural spaces. PURPOSE: To report an atypical radiological presentation of synovial sarcoma of the thoracic spine mimicking a nerve sheath tumor in an elderly adult and describe the management with review of the literature...
February 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29446850/superficial-acral-fibromyxoma-in-the-heel-with-new-vascular-features-on-dermoscopy
#7
Asude Kara Polat, Muge Gore Karaali, Asli Vefa Turgut Erdemir, Ayse Esra Koku Aksu, Cem Leblebici, Mehmet Salih Gurel
Superficial acral fibromyxoma (SAFM) is an uncommon mesencyhmal soft tissue tumor with a predilection for the acral extremites and nail bed involvement. SAFM is diagnosed with clinicopathological and immunohistochemical examination. Awareness of this rare tumor is important because of amounts of benign and malignant neoplasms. We report a case of SAFM in a rare localization in the heel with a new entity on dermoscopy.
February 15, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29445865/risk-of-recurrence-in-a-homogeneously-managed-pt3-differentiated-thyroid-carcinoma-population
#8
Nathalie Chereau, Etienne Dauzier, Gaëlle Godiris-Petit, Séverine Noullet, Isabelle Brocheriou, Laurence Leenhardt, Camille Buffet, Fabrice Menegaux
BACKGROUND: International guidelines for the management of differentiated thyroid cancers are based on the 7th TNM classification: pT3 tumors are defined as differentiated thyroid cancers (DTCs) measuring more than 4 cm in their greatest dimension that are limited to the thyroid or any tumor with minimal extrathyroidal extension (ETE; sternothyroid muscle or perithyroid soft tissues). Differences in clinicohistological features and prognosis among patients with pT3 tumors remain controversial, and studies regarding pT3 subgroups are lacking...
February 14, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29445192/spry2-is-a-novel-met-interactor-that-regulates-metastatic-potential-and-differentiation-in-rhabdomyosarcoma
#9
Masum Saini, Aakanksha Verma, Sam J Mathew
Rhabdomyosarcoma (RMS) is a predominantly pediatric soft-tissue cancer where the tumor cells exhibit characteristics of the developing skeletal muscle, and the two most common sub-types are embryonal and alveolar RMS. Elevated activation of the receptor tyrosine kinase (RTK) MET is frequent in RMS and is thought to cause increased tumor metastasis and lack of differentiation. However, the reasons underlying dysregulated MET expression and activation in RMS are not well understood. Therefore, we explored the role of Sprouty 2 (SPRY2), a modulator of RTK signaling, in regulating MET...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29443850/does-an-algorithmic-approach-to-using-brachytherapy-and-external-beam-radiation-result-in-good-function-local-control-rates-and-low-morbidity-in-patients-with-extremity-soft-tissue-sarcoma
#10
Jason Klein, Alex Ghasem, Samuel Huntley, Nathan Donaldson, Martin Keisch, Sheila Conway
BACKGROUND: High-dose-rate brachytherapy (HDR-BT) and external-beam radiation therapy (EBRT) are two modalities used in the treatment of soft tissue sarcoma. Previous work at our institution showed early complications and outcomes for patients treated with HDR-BT, EBRT, or a combination of both radiation therapy modalities. As the general indications for each of these approaches to radiation therapy differ, it is important to evaluate the use of each in an algorithmic way, reflecting how they are used in contemporary practice at sites that use these treatments...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29443772/primary-leiomyosarcoma-in-the-colon-a-case-report
#11
Jing Yang
RATIONALE: Leiomyosarcoma (LMS) is a common type of soft tissue sarcoma. Primary colonic LMS in general is a very rare entity, accounting for 1% to 2% of gastrointestinal malignancies. PATIENT CONCERNS: We report a case of 55-year-old female who presented with a sudden onset of sharp right lower quadrant abdominal pain. Electronic colonoscopy showed a normal lumen. However, an abdominal computed tomography scan revealed a mass of soft tissue attenuation inseparable from the ascending colon which appeared as a gastrointestinal stromal tumor (GIST)...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29441326/a-rare-case-of-primary-intrapulmonary-neurilemmoma-diagnosed-in-a-43-year-old-asymptomatic-man-with-a-well-defined-intrapulmonary-mass
#12
Serafeim Chrysikos, Maria Kaponi, Christina Triantafillidou, Theodoros Karampitsakos, Argyrios Tzouvelekis, Maria Anyfanti, Konstantinos Marossis, Marios Konstantinou, Rodoula Tringidou, Demosthenes Bouros, Katerina Dimakou
Neurilemmoma (NL), also termed schwannoma, presents as a well-circumscribed and encapsulated mass in the human body and is almost always solitary. CT scan of a patient with NL shows a round, ovoid, or lobulated well-demarcated solid mass of soft tissue density. Primary intrathoracic neurogenic tumors location varies. However, the development of such tumors is by far more common in the costovertebral angle of the posterior mediastinum. Here, we report a rare case of a 43-year-old patient, never smoker and previously healthy, who presented with a mass adjacent to the right pulmonary hilum...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29439882/radiation-therapy-to-sites-of-metastatic-disease-as-part-of-consolidation-in-high-risk-neuroblastoma-can-long-term-control-be-achieved
#13
Dana L Casey, Ken L Pitter, Brian H Kushner, Nai-Kong V Cheung, Shakeel Modak, Michael P LaQuaglia, Suzanne L Wolden
PURPOSE: As part of consolidative therapy in high-risk neuroblastoma, modern protocols recommend radiation therapy (RT) both to the primary site and to sites of metastatic disease that persist after induction chemotherapy. Although there are abundant data showing excellent local control (LC) with 21 Gy directed at the primary site, there are few data describing the feasibility and efficacy of RT directed at metastatic sites of disease as part of consolidation. METHODS AND MATERIALS: All patients with neuroblastoma who received RT to metastatic sites of disease as a part of consolidative therapy at a single institution between 2000 and 2015 were reviewed...
January 9, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29437879/characterizing-the-potency-and-impact-of-carbon-ion-therapy-in-a-primary-mouse-model-of-soft-tissue-sarcoma
#14
Jeremy Michael Brownstein, Amy Jordan Wisdom, Katherine D Castle, Yvonne M Mowery, Peter M Guida, Chang-Lung Lee, Francesco Tommasino, Chiara La Tessa, Emanuele Scifoni, Junheng Gao, Lixia Luo, Lorraine Da Silva Campos, Yan Ma, Nerissa Williams, Sin-Ho Jung, Marco Durante, David G Kirsch
Carbon ion therapy (CIT) offers several potential advantages for treating cancers compared with X-ray and proton radiotherapy including increased biological efficacy and more conformal dosimetry. However, CIT potency has not been characterized in primary tumor animal models. Here, we calculate the relative biological effectiveness (RBE) of carbon ions compared to X-rays in an autochthonous mouse model of soft tissue sarcoma. We used Cre/loxP technology to generate primary sarcomas in KrasLSL-G12D/+; p53fl/fl mice...
February 7, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29436307/cancers-of-the-major-salivary-gland
#15
Eugene Son, Aru Panwar, Charles H Mosher, Daniel Lydiatt
Salivary gland malignancies are rare tumors that comprise multiple histologic entities with diverse clinical behavior. Mucoepidermoid carcinoma is the most frequent primary salivary malignancy, followed by adenoid cystic and acinic cell carcinoma. Although most salivary malignancies are asymptomatic, presentation with a rapidly enlarging mass may be accompanied by pain, functional neurologic deficits, soft-tissue invasion, or nodal enlargement. Assessment of clinical behavior and physical exam greatly contributes to diagnostic workup...
February 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29435853/do-patients-whose-tumor-achieved-a-pathological-response-relapse-at-specific-sites-a-substudy-of-the-eortc-10994-big-1-00-trial
#16
Kim C Aalders, Nathan Touati, Konstantinos Tryfonidis, Mylène Annonay, Saskia Litiere, Jonas Bergh, Alexandre Bodmer, David A Cameron, Hervé R Bonnefoi
PURPOSE: To determine the sites of first distant relapse in patients with or without pCR following neoadjuvant chemotherapy in breast cancer patients enrolled in the EORTC 10994/BIG-1-00 trial. METHODS: We included patients enrolled in the EORTC 10994/BIG-1-00 trial who received at least one chemotherapy cycle before surgery and who had been diagnosed with a distant relapse. pCR was defined as no evidence of residual invasive cancer in the primary tumor and axillary lymph nodes with or without residual ductal carcinoma in situ...
February 12, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29435023/primary-malignant-perivascular-epithelioid-cell-neoplasm-pecoma-of-the-bone-mimicking-granular-cell-tumor-in-core-biopsy-a-case-report-and-literature-review
#17
Sam Sadigh, Preya Shah, Kristy Weber, Ronnie Sebro, Paul J Zhang
The present study investigated the case of a 46-year-old female with primary malignant perivascular epithelioid cell neoplasm (PEComa) of the femur. The patient presented with a 5-month history of right distal thigh pain following trauma. Radiographs of the right distal femur revealed a mixed lytic and sclerotic lesion with subtle areas of cortical destruction and soft tissue extension, consistent with an aggressive tumor. A core biopsy revealed an epithelioid tumor with granular cell features, but a definitive diagnosis could not be made...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434923/long-term-outcomes-of-patients-with-soft-tissue-sarcoma-of-the-chest-wall-analysis-of-the-prognostic-significance-of-microscopic-margins
#18
Kamran Harati, Jonas Kolbenschlag, Jens Bohm, Hiltrud Niggemann, Hamid Joneidi-Jafari, Ingo Stricker, Marcus Lehnhardt, Adrien Daigeler
Data on prognostic factors and treatment outcomes for chest wall soft tissue sarcomas (STS) are sparse. Wide resections with negative margins are the mainstay of therapy, but the prognostic impact of surgical margins remains controversial. The purpose of the present study was to determine the significance of microscopic margins through a long-term follow-up. The associations between local recurrence-free survival (LRFS), overall survival (OS) and potential prognostic factors were retrospectively assessed in a consecutive series of 110 patients who were suitable for surgical treatment with curative intent...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434876/a-retrospective-single-center-cohort-study-on-65-patients-with-primary-retroperitoneal-liposarcoma
#19
Yi-Xi Wu, Jun-Yan Liu, Jia-Jia Liu, Peng Yan, Bo Tang, You-Hong Cui, Yong-Liang Zhao, Yan Shi, Ying-Xue Hao, Pei-Wu Yu, Feng Qian
Primary retroperitoneal liposarcoma (PRPLS) is the most common soft tissue malignancy of the retroperitoneum. To determine the pathological features and the curative effects of surgery in patients with PRPLS, and to elucidate key prognostic factors, the present study retrospectively analyzed the clinical cases of 65 patients with PRPLS. Immunohistochemical analysis demonstrated that vimentin and Ki-67 are better indicators for PRPLS immunohistochemical diagnosis compared with S-100 protein. S-100 protein was predominantly expressed in well-differentiated PRPLS...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434830/pediatric-sarcomas
#20
Junhua Cao, Qi An, Lei Wang
Sarcomas arise from primitive mesenchymal cells, which are classified, into two main groups: Bone and soft tissue sarcomas. We have searched all-important electronic databases including Google scholar and PubMed for the collection of latest literature pertaining to pediatric sarcomas. Latest literature confirmed that these tumors are relatively rare and represent only 1% of all malignancies but they have higher incidence in children. Pediatric sarcomas comprise about 13% of all pediatric malignancies and are ranked third in childhood cancers...
February 2018: Oncology Letters
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