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https://www.readbyqxmd.com/read/28241093/phase-1-2-study-of-immunotherapy-with-dendritic-cells-pulsed-with-autologous-tumor-lysate-in-patients-with-refractory-bone-and-soft-tissue-sarcoma
#1
Shinji Miwa, Hideji Nishida, Yoshikazu Tanzawa, Akihiko Takeuchi, Katsuhiro Hayashi, Norio Yamamoto, Eishiro Mizukoshi, Yasunari Nakamoto, Shuichi Kaneko, Hiroyuki Tsuchiya
BACKGROUND: There are limited options for the curative treatment of refractory bone and soft tissue sarcomas. The purpose of this phase 1/2 study was to assess the immunological and clinical effects of dendritic cells (DCs) pulsed with autologous tumor lysate (TL) in patients with advanced bone and soft tissue sarcomas. METHODS: Thirty-seven patients with metastatic or recurrent sarcomas were enrolled in this study. Peripheral blood mononuclear cells obtained from the patients were suspended in media containing interleukin 4 (IL-4) and granulocyte-macrophage colony-stimulating factor...
February 27, 2017: Cancer
https://www.readbyqxmd.com/read/28237565/peripheral-nerve-schwannoma-a-review-of-varying-clinical-presentations-and-imaging-findings
#2
Pradeep Albert, Jalpen Patel, Karim Badawy, William Weissinger, Marc Brenner, Ian Bourhill, John Parnell
A schwannoma or neurilemmoma is a benign, isolated, noninvasive, and encapsulated tumor originating from Schwann cells of the peripheral nerve sheath. The incidence of a schwannoma occurring in the foot and ankle is rare, with prevalence rate of 1% to 10%. Schwannomas have no sex predilection, and they commonly occur in patients in their fourth decade. Malignant transformation of benign schwannoma is unusual; however, it is important to note that malignant variants of schwannomas do exist and account for about 5% to 10% of all soft tissue sarcomas...
February 22, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28235631/clinicopathologic-features-of-peripheral-nerve-sheath-tumors-involving-the-eye-and-ocular-adnexa
#3
Mingjuan L Zhang, Maria J Suarez, Thomas M Bosley, Fausto J Rodriguez
Peripheral nerve sheath tumors (PNSTs) are known to occur in the orbit and comprise 4% of all orbital tumors, but have not been well-studied in contemporary literature. Ninety specimens involving the eye and ocular adnexa (1979-2015) from 67 patients were studied. The mean age was 32.5years. Locations included orbit (58.9%), eyelid (60.0%) and other ocular adnexa. A large majority of specimens were neurofibromas (70.0%), followed by schwannomas (11.1%), neuromas (11.1%), granular cell tumors (n=4), nerve sheath myxomas (n=2), and malignant peripheral nerve sheath tumor (n=1)...
February 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28230919/maxillary-ameloblastoma-factors-associated-with-risk-of-recurrence
#4
Rong Yang, Zheqi Liu, Canbang Peng, Wei Cao, Tong Ji
BACKGROUND: Maxillary ameloblastomas are rare and associated with an aggressive course because of the anatomic composition of the maxilla and adjacent structures. The risk factors associated with recurrence were analyzed in this retrospective study. METHODS: Cases of maxillary ameloblastoma reported in a tertiary hospital from 2005 to 2015 were analyzed to identify clinicopathological and radiological factors associated with recurrence using univariate and multivariate Cox regression analyses...
February 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28229172/external-beam-radiation-therapy-combined-with-limb-sparing-surgery-in-elderly-patients-70%C3%A2-years-with-primary-soft-tissue-sarcomas-of-the-extremities-a%C3%A2-retrospective-analysis
#5
Claudia Andrä, Alexander Klein, Hans Roland Dürr, Josefine Rauch, Lars Hartwin Lindner, Thomas Knoesel, Martin Angele, Andrea Baur-Melnyk, Claus Belka, Falk Roeder
PURPOSE: To report our experience with EBRT combined with limb-sparing surgery in elderly patients (>70 years) with primary extremity soft tissue sarcomas (STS). METHODS: Retrospectively analyzed were 35 patients (m:f 18:17, median 78 years) who all presented in primary situation without nodal/distant metastases (Charlson score 0/1 in 18 patients; ≥2 in 17 patients). Median tumor size was 10 cm, mainly located in lower limb (83%). Stage at presentation (UICC7th) was Ib:3%, 2a:20%, 2b:20%, and 3:57%...
February 22, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28229061/central-myxoma-myxofibroma-of-the-jaws-a-clinico-epidemiologic-review
#6
Agbara Rowland, Fomete Benjamin, Obiadazie Athanasius-Chukwudi, Omeje Uchenna-Kevin, Samaila Modupeola-Omotara
INTRODUCTION: Myxomas are a group of benign rare tumors of connective-tissue origin that occur in both hard (central) and soft tissues of the body. The aim of this study is to highlight our experience in the management of central myxoma of the jaw, with emphasis on its clinic-epidemiologic features as seen in our environment. MATERIALS AND METHODS: All patients who were managed for central myxoma of the jaw at the Oral and Maxillofacial Surgery department of a regional University Teaching Hospital between September 1997 and October 2015 were retrospectively studied...
January 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28227041/deformable-resection-process-map-for-intraoperative-cutting-guides
#7
Megumi Nakao, Kojiro Taura, Tetsuya Matsuda, Megumi Nakao, Kojiro Taura, Tetsuya Matsuda, Megumi Nakao, Kojiro Taura, Tetsuya Matsuda
In this paper, we will introduce the concept of deformable resection process mapping as a time-varying geometric guide for soft tissue tumor resection procedures. The deformable resection process map (RPM) estimates the local appearance of vascular structures after cuts as a novel guide. The RPM can be directly generated from patient-specific medical images using volumetric resampling techniques. Since user input of some cutting points is the only requirement for generating the RPM, the developed software will be directly available for clinical use to preview surgical procedures and intraoperative workflow management without time-consuming setups or additional workloads...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225971/giant-cell-tumor-of-the-tendon-sheath-a-rare-periungual-location-simulating-myxoid-cyst
#8
Renan Minotto, Camila Britto Rodrigues, Aline Barcellos Grill, Roque Furian
Giant cell tumor of the tendon sheath is a benign soft tissue tumor most frequent between the third and fifth decades of life. It can mimic and make differential diagnoses with several hand tumors. Definitive diagnosis and the treatment of choice are reached with complete resection and histopathological examination. Here we describe a case with clinical presentation similar to that of a myxoid cyst.
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28224035/colonic-intussusception-in-descending-colon-an-unusual-presentation-of-colon-lipoma
#9
Reza Bagherzadeh Saba, Amir Sadeghi, Neda Rad, Mohammad Taghi Safari, Farnoush Barzegar
Lipomas of the colon are relatively rare benign soft tissue tumors derived from mature adipocytes of mesenchymatic origin. During colonoscopy, surgery or autopsy they are generally discovered incidentally. Most cases are asymptomatic, with a small tumor size, and do not need any special treatment. However, in the cases with larger in size of tumor some symptoms such as anemia, abdominal pain, constipation, diarrhea, bleeding, or intussusception may be presented. We reported a 47-year-old woman with colonic intussusception in the descending colon caused by colonic lipoma and diagnosed after surgical exploration for obstructive colonic mass...
December 2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28222892/fdg-uptake-in-normal-tissues-assessed-by-pet-during-treatment-has-prognostic-value-for-treatment-results-in-head-and-neck-squamous-cell-carcinomas-undergoing-radiochemotherapy
#10
Sebastian Zschaeck, Steffen Löck, Stefan Leger, Robert Haase, Anna Bandurska-Luque, Steffen Appold, Jörg Kotzerke, Daniel Zips, Christian Richter, Volker Gudziol, Andreas Schreiber, Klaus Zöphel, Michael Baumann, Mechthild Krause
BACKGROUND AND PURPOSE: Pronounced early side effects have been suggested to be a positive prognostic factor in patients undergoing chemo-radio-therapy (CRT) for head and neck squamous cell carcinomas (HNSCC). We assessed the utility of positron emission tomography (PET) during treatment to analyze the correlation of 18F-fluorodeoxyglucose (FDG) uptake in off target structures within the irradiated volume with outcome. MATERIAL AND METHODS: Two independent cohorts of patients with locally advanced HNSCC, both treated within prospective clinical imaging trials with curatively intended CRT were retrospectively analyzed...
February 17, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28221727/docetaxel-bevacizumab-and-gemcitabine-for-very-high-risk-sarcomas-in-adolescents-and-young-adults-a-single-center-experience
#11
Christopher Kuo, Paul M Kent, Antonio D Logan, Karen B Tamulonis, Kristen L Dalton, Marta Batus, Karen Fernandez, Rebecca E Mcfall
BACKGROUND: Adolescent and young adult (AYA) patients with very high risk sarcomas have poor outcomes and are in need of novel therapies. PROCEDURE: From January 2005 to February 2016, we retrospectively identified all AYA patients with relapsed or metastatic high-grade sarcomas, who were treated with at least one cycle of docetaxel (T), bevacizumab (A), and gemcitabine (G) (TAG ; T = 100 mg/m(2) Day 8, A = 15 mg/kg Day 1, G = 1,000 mg/m(2) Days 1 and 8). RESULTS: Fourteen patients, median age of 20 (15-30), received a total of 80 cycles of TAG, and were followed for a median of 83 months...
April 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28219566/immunoglobulin-g4-related-periaortitis-involving-the-aortic-arch-mimicking-a-mediastinal-tumor
#12
Min Jae Cha, Semin Chong, Yang Soo Kim, Byungjoon Park, Ja Hee Seo, Eun Sung Lee
Immunoglobulin G4 (IgG4)-related sclerosing disease is a recently proposed systemic fibroinflammatory disease entity, with periaortitis as a representative manifestation in the cardiovascular system. We present a case of IgG4-related periaortitis involving the aortic arch and proximal great vessels, mimicking an anterior mediastinal tumor on computed tomography. In patients with a soft tissue mass along the aortic wall, IgG4-related periaortitis should be included as a differential diagnosis and timely serologic investigation should be performed to prevent unnecessary surgery, because the disease shows a remarkable response to corticosteroids...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28219303/extra-articular-diffuse-type-tenosynovial-giant-cell-tumor-with-benign-histological-features-resulting-in-fatal-pulmonary-metastases
#13
Toshihisa Osanai, Hiroaki Suzuki, Hiroaki Hiraga, Tamotsu Soma, Takayuki Nojima
Diffuse-type tenosynovial giant cell tumor (TS-GCT) is categorized as a locally aggressive but non-metastasizing neoplasm according to the WHO classification. Herein, we report an extremely rare case of a 41-year-old woman who developed multiple metastases from diffuse TS-GCT with benign histological features. The patient complained of a painful buttock mass and imaging studies revealed a soft tissue tumor of the buttock and multiple pulmonary nodules. The buttock tumor was excised and the final diagnosis was extra-articular diffuse-type TS-GCT...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28218630/jejunal-carcinoid-tumors-presenting-as-small-bowel-obstruction
#14
David Ballard, Ryan Fransman, Guillermo Sangster, Matthew Ayo, Navdeep Samra
Carcinoid tumors are the most common form of gut neuroendocrine tumors, however, they rarely present with small bowel obstruction. We present a case of a 65-year-old woman without prior abdominal operations who presented with symptoms of small bowel obstruction. Computed tomography (CT) showed multiple air fluid levels and a transition point in the left mesentery with two soft tissue densities at the same level. The patient was taken to the operating room for surgical exploration, which showed two intramural masses in the mid and distal jejunum, which surgical pathology showed to be stage IIIB carcinoid tumor...
January 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28218026/gingival-fibrosarcoma-in-a-horse
#15
Apryle Horbal, Padraic M Dixon
A 4-year-old thoroughbred cross mare was referred to the University of Edinburgh Veterinary School Equine Hospital for treatment of a soft tissue tumor on the buccal gingival margin of the rostral right maxillary cheek teeth. The lesion was initially surgically excised and diagnosed as a fibrosarcoma via histopathology. Adjunctive treatment with intralesional cisplatin chemotherapy was begun. The tumor recurred and was repeatedly treated with intralesional cisplatin injections and additional surgical resection over the course of 14 weeks...
December 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28217473/cd34-negative-superficial-acral-fibromyxoma-a-rare-case-report
#16
Reza M Robati, Sahar Dadkhahfar, Azadeh Rakhshan
Superficial acral fibromyxoma (SAF) is a slow growing soft tissue tumor that mainly appears in the acral areas. Here, we report a case of a SAF with distinctive immunophenotype charachteristics. An 18-year-old female was referred to our clinic with the complaint of painless subungual nodule of great toe for a few months. The diagnosis of SAF was made according to histopathology and immunohistochemical (IHC) study, however, the IHC assessment showed positive staining with vimentin, focal reaction with smooth muscle actin, negative reaction with CD34, and positive staining pattern with CD99...
January 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28217455/neoplastic-diseases-of-the-spermatic-cord-an-overview-of-pathological-features-evaluation-and-management
#17
REVIEW
Gautam Dagur, Jason Gandhi, Kailash Kapadia, Rafid Inam, Noel L Smith, Gargi Joshi, Sardar Ali Khan
Extracellular tumors found with the spermatic cord, known as neoplasms, are usually identified to be benign. However, the accurate and timely diagnosis of spermatic cord masses is highly crucial, especially when most results are often overlooked or unclear. In this review, we discuss the anatomy and embryology of the spermatic cord. Upon rooting these fundamental concepts, we discuss an array of benign and malignant neoplastic tumors, including their origin, pathological features, clinical evaluation and management, as well as other case-specific characteristics of unique presentation...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28216820/siliconomas-of-the-lower-limb-tumour-like-excision-and-reconstruction
#18
Tommaso Agostini, Raffaella Perello
BACKGROUND: Silicone oil injection can cause several complications including pain, cellulitis, abscesses, skin compromise, migration, embolism and multiorgan failure. Oil-infested tissue excision remains the solely treatment to prevent such complications. OBJECTIVES: The authors evaluate tumor-like excision of the oil-infested tissue as a treatment for patients experiencing silicone injections in the lower limbs, to both preserve aesthetic appearance and solve further risk of complication from silicone...
September 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28216303/superficial-acral-fibromyxoma-a-rare-soft-tissue-tumor
#19
José M Braga, Isabel Bartosch, Helena Baldaia, Isabel Oliveira, Aurea Canelhas, Álvaro Silva
Superficial acral fibromyxoma is a rare clinical entity, first described in 2001. It is a soft tissue tumor with a predilection for the fingers and toes. Since it was described, few cases have been reported. We present a case of an 88-year-old male with a history of a slow-growing lump in his left great toe after local trauma. The patient underwent surgical excision, and pathologic analysis revealed the diagnosis of superficial acral fibromyxoma. Although an unusual diagnosis, surgeons should be aware of this myxoid tumor, which requires complete surgical excision and short-term follow-up to detect recurrence...
February 16, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28214556/isolated-limb-infusion-as-a-limb-salvage-strategy-for-locally-advanced-extremity-sarcoma
#20
John E Mullinax, Hidde M Kroon, John F Thompson, Neel Nath, Paul J Mosca, Jeffrey M Farma, Rajendra Bhati, Danielle Hardmann, Sean Sileno, Cristina O'Donoghue, Matthew Perez, Syeda Mahrukh Hussnain Naqvi, Y Ann Chen, Ricardo J Gonzalez, Jonathan S Zager
BACKGROUND: Treatment-resistant, locally advanced soft tissue sarcomas often require amputation for complete tumor extirpation. Isolated limb infusion (ILI) selectively delivers high-dose chemotherapy to the extremity in an attempt to achieve limb salvage. The aim of this study was to report perioperative and oncologic outcomes after ILI in patients with extremity soft tissue sarcomas. STUDY DESIGN: From 1994 to 2016, 77 patients underwent 84 ILIs at a total of 5 institutions...
February 15, 2017: Journal of the American College of Surgeons
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