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https://www.readbyqxmd.com/read/29779692/development-and-validation-of-an-uhplc-hrms-ms-assay-for-nine-toxic-alkaloids-from-endophyte-infected-pasture-grasses-in-horse-serum
#1
Wiebke Rudolph, Daniela Remane, Dirk K Wissenbach, Frank T Peters
Endophyte fungi (e.g. Epichloë ssp. and Neotyphodium ssp.) in symbiosis with pasture grasses (e.g. Festuca arundinacaea and Lolium perenne) can produce toxic alkaloids, which are suspected to be involved in equine diseases such as fescue toxicosis, ryegrass staggers, and equine fescue oedema. The aim of this study was, therefore, to develop and validate a quantification method for these and related alkaloids: ergocristine, ergocryptine, ergotamine, ergovaline, lolitrem B, lysergic acid, N-acetylloline, N-formylloline, peramine, and paxilline in horse serum...
May 7, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29772053/delivery-outcome-after-trial-of-labor-in-nulliparous-women-over-40-years-of-age-a-population-based-study
#2
Victoria Ankarcrona, Daniel Altman, Anna-Karin Wikström, Bo Jacobsson, Sophia Brismar Wendel
INTRODUCTION: An increasing proportion of nulliparous women are over 40 years and labor is more often induced. The aim of this study was to assess delivery outcome in women over 40 years, accounting for the interaction between age and induction. MATERIAL AND METHODS: Population-based study of 1 644 598 nulliparous women with live singleton cephalic term deliveries 1992 to 2011. Risks of intrapartum cesarean section, operative vaginal delivery, obstetric anal sphincter injury (OASIS), and 5-minutes Apgar score <7 were calculated in women ≥40 years with induced or spontaneous labor, and women <40 years with induced labor by unconditional logistic regression, and presented with crude and adjusted odds ratios (aOR) with 95% confidence intervals (95%CI)...
May 17, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29768662/immersion-in-water-during-labour-and-birth
#3
REVIEW
Elizabeth R Cluett, Ethel Burns, Anna Cuthbert
BACKGROUND: Water immersion during labour and birth is increasingly popular and is becoming widely accepted across many countries, and particularly in midwifery-led care settings. However, there are concerns around neonatal water inhalation, increased requirement for admission to neonatal intensive care unit (NICU), maternal and/or neonatal infection, and obstetric anal sphincter injuries (OASIS). This is an update of a review last published in 2011. OBJECTIVES: To assess the effects of water immersion during labour and/or birth (first, second and third stage of labour) on women and their infants...
May 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29766613/cortical-thickness-estimations-of-freesurfer-and-the-cat12-toolbox-in-patients-with-alzheimer-s-disease-and-healthy-controls
#4
Rene Seiger, Sebastian Ganger, Georg S Kranz, Andreas Hahn, Rupert Lanzenberger
BACKGROUND AND PURPOSE: Automated cortical thickness (CT) measurements are often used to assess gray matter changes in the healthy and diseased human brain. The FreeSurfer software is frequently applied for this type of analysis. The computational anatomy toolbox (CAT12) for SPM, which offers a fast and easy-to-use alternative approach, was recently made available. METHODS: In this study, we compared region of interest (ROI)-wise CT estimations of the surface-based FreeSurfer 6 (FS6) software and the volume-based CAT12 toolbox for SPM using 44 elderly healthy female control subjects (HC)...
May 15, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29765702/is-radiographic-progression-in-radiographic-axial-spondyloarthritis-related-to-matrix-metalloproteinase-degradation-of-extracellular-matrix
#5
Anne Sofie Siebuhr, Desirée van der Heijde, Anne-C Bay-Jensen, Morten Asser Karsdal, Robert Landewé, Astrid van Tubergen, Sofia Ramiro
Background: Radiographic axial spondyloarthritis (r-axSpA) is associated with extracellular matrix (ECM) remodelling of affected tissues. We investigated whether there was a relationship between biomarkers of ECM remodelling and 2-year radiographic progression in r-axSpA. Methods: Patients from the Outcome in Ankylosing Spondylitis International Study (OASIS) were included if they had serum, clinical and spinal radiographic assessments available at baseline and 2 years later...
2018: RMD Open
https://www.readbyqxmd.com/read/29758468/overcoming-the-stability-solubility-and-extraction-challenges-in-reversed-phase-uhplc-ms-ms-bioanalysis-of-a-phosphate-drug-and-its-prodrug-in-blood-lysate
#6
Long Yuan, Shenita Basdeo, Qin C Ji
BMS-986104 is a S1P1 R modulator drug candidate under development and has been evaluated in Phase I clinical trials. BMS-986104 functions as a prodrug and undergoes enzymatic transformations in vivo to form the pharmacologically active phosphate drug, BMS-986104-P. Here, we report approaches to overcome the stability, solubility and extraction challenges in developing a sensitive, accurate and rugged LC-MS/MS method for the simultaneous quantification of the phosphate drug and its prodrug in blood lysate. An effective stabilization strategy using a cocktail of phosphatase and kinase inhibitors was developed to ensure the stability of both analytes during sample collection, storage, and processing...
May 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29754121/early-intervention-services-in-greece-time-to-focus-on-people-at-high-risk
#7
S I Bargiota, V P Bozikas, G Garyfallos, P McGuire
Over the last twenty years, a lot of early intervention services operate worldwide with the aim of offering assistance and promoting the early diagnosis and management, not only of people who experience a first episode of psychosis but also of individuals that are at high risk of developing psychosis. The early intervention services that operate in other countries have been reviewed in correlation with the current status of early intervention services for psychosis in Greece. Early intervention services were first established in Australia, and now hundreds of similar programs exist in Europe, North America and Asia...
January 2018: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29752221/reprint-of-oasis-obesity-awareness-and-insight-scale
#8
Philip Gerretsen, Julia Kim, Parita Shah, Lena Quilty, Thushanthi Balakumar, Fernando Caravaggio, Eric Plitman, Jun Ku Chung, Yusuke Iwata, Bruce G Pollock, Satya Dash, Sanjeev Sockalingam, Ariel Graff-Guerrero
AIMS: Impaired illness awareness or not accepting that one has obesity is an understudied phenomenon that may negatively influence treatment adherence and clinical outcomes. The purpose of this study was to perform a systematic review of available measures of obesity awareness, and subsequently develop and validate a novel scale that measures the core domains of obesity awareness. METHODS: A systematic review of the literature revealed no illness specific measure of subjective obesity awareness...
May 8, 2018: Primary Care Diabetes
https://www.readbyqxmd.com/read/29748310/do-laboratory-challenge-tests-for-occupational-asthma-represent-what-happens-in-the-workplace
#9
P Sherwood Burge, Vicky C Moore, Alastair S Robertson, Gareth I Walters
INTRODUCTION: Specific inhalation challenge (SIC) is the diagnostic reference standard for occupational asthma, however the significance of a positive test is doubtful unless it can be reproduced by usual work exposures. We have compared the timing and responses during SIC in hospital to Oasys analysis of serial PEF during usual work exposures. METHODS: All workers with a positive SIC to occupational agents between 2006 and 2015 were asked to measure PEF 2-hourly from waking to sleeping for 4 weeks during usual occupational exposures...
May 10, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29748091/development-and-validation-of-a-hydrophilic-interaction-liquid-chromatography-tandem-mass-spectrometry-method-for-the-quantification-of-the-antidiabetic-drug-metformin-and-six-others-pharmaceuticals-in-wastewater
#10
Reinhard Oertel, Julien Baldauf, Julia Rossmann
A rapid and sensitive hydrophilic interaction liquid chromatography (HILIC)-tandem mass spectrometry method was developed and fully validated for the simultaneous determination of the antidiabetic drug metformin and six further pharmaceuticals (atenolol, gabapentin, levofloxacin, ciprofloxacin, propranolol and trimethoprim) in influent and effluent wastewater. Five deuterated related compounds were used as internal standards in order to control the extraction, injection and ionization variability. Two solid phase extraction methods and Oasis HLB 1cc cartridge, using only 1 mL sample with acid or basic pH-value were optimized and compared in order to match the specificity of both influent and effluent wastewater matrixes...
May 4, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29743462/-quantitative-analysis-of-l-ascorbic-acid-and-erythorbic-acid-in-foods-by-hplc-and-confirmation-method-by-lc-ms-ms
#11
Yuki Sadamasu, Mari Morikawa, Narue Sakamaki, Kimio Monma, Chigusa Kobayashi
Analysis of L-ascorbic acid (AsA) and erythorbic acid (ErA) in foods is generally performed by HPLC measurement after extraction with metaphosphoric acid solution. But this method can not always measure the concentrations of AsA and ErA precisely due to the presence of interfering compounds, and the reproducibility of retention time is poor. We considered that quantitative analysis by HPLC and confirmation by LC-MS/MS using an identical extraction solvent might be an effective approach for AsA and ErA analysis...
2018: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/29741052/-spatial-variation-of-soil-carbon-and-stable-isotopes-in-the-southern-margin-desert-of-junggar-basin-china
#12
Na Wang, Wen Qiang Xu, Hua Jun Xu, Yi Xing Feng, Chao Fan Li
The southern margin desert of Junggar Basin in the central arid region of Asia was selec-ted as the study area. To gain insight into the distribution characteristic of stable carbon isotope and the relationship between the change of soil carbon and the distance to oasis of soil organic carbon (SOC) and soil inorganic carbon (SIC), three belt transects were set according to the distance between the desert and the oasis in edge, middle and hinterland of the desert respectively, and collected the soil profile samples with depth of 2 m...
July 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29741036/-water-sources-of-nitraria-sibirica-and-response-to-precipitation-in-two-desert-habitats
#13
Hai Zhou, Wen Zhi Zhao, Zhi Bin He
Nitraria sibirica usually exists in a form of nebkhas, and has strong ecological adaptability. The plant species has distinctive function for wind prevention and sand fixation, and resistance drought and salt. However, the water condition is still a limiting factor for the plant survival and development. In order to understand the water use strategy of the plant in different desert habitats, we selected the N. sibirica growing in sandy desert habitat and gravel desert habitat to study the seaso-nal variation of plant water sources and response to precipitation at the edge of the oasis of Linze in the Hexi Corridor...
July 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29734121/factors-associated-with-obstetric-anal-sphincter-injuries-in-midwife-led-birth-a-cross-sectional-study
#14
Jorunn Wik Tunestveit, Elham Baghestan, Gerd Karin Natvig, Geir Egil Eide, Anne Britt Vika Nilsen
INTRODUCTION: Obstetric anal sphincter injurie (OASI) in vaginal births are a serious complication, and are associated with maternal morbidity. Focus on modifiable factors in midwives clinical skills and competences contributing to prevent the occurrence of OASI are essential. The objective of this study was to investigate the association between OASI and factors related to midwife-led birth such as manual support of perineum, active delivery of baby's shoulders, maternal birth position, and pushing and breathing techniques in second stage of labour...
April 21, 2018: Midwifery
https://www.readbyqxmd.com/read/29731758/interspecies-interactions-in-relation-to-root-distribution-across-the-rooting-profile-in-wheat-maize-intercropping-under-different-plant-densities
#15
Yifan Wang, Yazhou Qin, Qiang Chai, Fuxue Feng, Cai Zhao, Aizhong Yu
In wheat-maize intercropping systems, the maize is often disadvantageous over the wheat during the co-growth period. It is unknown whether the impaired growth of maize can be recovered through the enhancement of the belowground interspecies interactions. In this study, we (i) determined the mechanism of the belowground interaction in relation to root growth and distribution under different maize plant densities, and (ii) quantified the "recovery effect" of maize after wheat harvest. The three-year (2014-2016) field experiment was conducted at the Oasis Agriculture Research Station of Gansu Agricultural University, Wuwei, Northwest China...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29724255/optimizing-acupuncture-treatment-for-dry-eye-syndrome-a-systematic-review
#16
Bong Hyun Kim, Min Hee Kim, Se Hyun Kang, Hae Jeong Nam
BACKGROUND: In a former meta-analysis review, acupuncture was considered a potentially effective treatment for dry eye syndrome (DES), but there were heterogeneities among the outcomes. We updated the meta-analysis and conducted subgroup analysis to reduce the heterogeneity and suggest the most effective acupuncture method based on clinical trials. METHODS: We searched for randomized controlled trials (RCTs) in 10 databases (MEDLINE, EMBASE, CENTAL, AMED, SCOPUS, CNKI, Wangfang database, Oriental Medicine Advanced Searching Integrated System (OASIS), Koreamed, J-stage) and searched by hand to compare the effects of acupuncture and artificial tears (AT)...
May 3, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29722226/-soil-quality-assessment-under-different-cropping-system-and-straw-management-in-farmland-of-arid-oasis-region
#17
Peng Peng Zhang, Xiao Zhen Pu, Wang Feng Zhang
To reveal the regulatory mechanism of agricultural management practices on soil quality, an experiment was carried out to study the different cropping system and straw management on soil organic carbon and fractions and soil enzyme activity in farmland of arid oasis region, which would provide a scientific basic for enhancing agricultural resources utilization and sustainable development. In crop planting planning area, we took the mainly crop (cotton, wheat, maize) as research objects and designed long-term continues cropping and crop rotation experiments...
March 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29714358/dice-overlap-measures-for-objects-of-unknown-number-application-to-lesion-segmentation
#18
Ipek Oguz, Aaron Carass, Dzung L Pham, Snehashis Roy, Nagesh Subbana, Peter A Calabresi, Paul A Yushkevich, Russell T Shinohara, Jerry L Prince
The Dice overlap ratio is commonly used to evaluate the performance of image segmentation algorithms. While Dice overlap is very useful as a standardized quantitative measure of segmentation accuracy in many applications, it offers a very limited picture of segmentation quality in complex segmentation tasks where the number of target objects is not known a priori , such as the segmentation of white matter lesions or lung nodules. While Dice overlap can still be used in these applications, segmentation algorithms may perform quite differently in ways not reflected by differences in their Dice score...
2018: Brainlesion: glioma, multiple sclerosis, stroke and traumatic brain injuries: third International Workshop, BrainLes 2017, held in conjunction with MICCAI 2017, Quebec City, QC, Canada, September 14, 2017, Revised selected papers
https://www.readbyqxmd.com/read/29714357/joint-intensity-fusion-image-synthesis-applied-to-multiple-sclerosis-lesion-segmentation
#19
Greg M Fleishman, Alessandra Valcarcel, Dzung L Pham, Snehashis Roy, Peter A Calabresi, Paul Yushkevich, Russell T Shinohara, Ipek Oguz
We propose a new approach to Multiple Sclerosis lesion segmentation that utilizes synthesized images. A new method of image synthesis is considered: joint intensity fusion (JIF). JIF synthesizes an image from a library of deformably registered and intensity normalized atlases. Each location in the synthesized image is a weighted average of the registered atlases; atlas weights vary spatially. The weights are determined using the joint label fusion (JLF) framework. The primary methodological contribution is the application of JLF to MRI signal directly rather than labels...
2018: Brainlesion: glioma, multiple sclerosis, stroke and traumatic brain injuries: third International Workshop, BrainLes 2017, held in conjunction with MICCAI 2017, Quebec City, QC, Canada, September 14, 2017, Revised selected papers
https://www.readbyqxmd.com/read/29703068/electroacupuncture-for-migraine-protocol-for-a-systematic-review-of-controlled-trials
#20
Hongmin Chu, Jihye Seo, Cheolhyun Kim, Yeonju Moon, Dae Gill Kang, Ho Sub Lee, Kang-Keyng Sung, Sangkwan Lee
BACKGROUND AND OBJECTIVE: A migraine is one of the primary headache disorders. Acupuncture has been widely used to treat migraine. Furthermore, electroacupuncture (EA) treatment has been also used to treat migraine. However, there has been no systematic review by assessing efficacy and safety of EA on migraine. This protocol is developed to conduct a systematic review and meta-analysis to evaluate the evidences related to the effectiveness and safety of EA on migraine. METHODS AND ANALYSIS: This protocol follows the guideline according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Protocol and registered on the International Prospective Register of Systematic Reviews (PROSPERO)...
April 2018: Medicine (Baltimore)
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