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https://www.readbyqxmd.com/read/28921639/standing-in-the-shifting-sands-of-molecular-targeting-and-precision-medicine-is-the-oasis-of-21st-century-oncology-therapeutics
#1
Lucy Lee, Lionel D Lewis
No abstract text is available yet for this article.
October 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28917789/chemometric-optimization-of-the-extraction-and-derivatization-of-parabens-for-their-determination-in-water-samples-by-rotating-disk-sorptive-extraction-and-gas-chromatography-mass-spectrometry
#2
Mercedes Becerra-Herrera, Valentina Miranda, Daniel Arismendi, Pablo Richter
A combination of rotating disk sorptive extraction (RDSE) using Oasis® HLB as the sorbent phase and gas chromatography mass spectrometry (GC-MS) has been performed for the determination of four of the most widely used parabens: methylparaben, ethylparaben, propylparaben and n-butylparaben. The extraction and derivatization of the analytes in water samples were optimized by using factorial (screening) and Doehlert designs, thus reducing the number of analyses with the concomitant reduction of time, reagents, waste, samples and cost...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28915858/risk-of-obstetric-anal-sphincter-injury-increases-with-maternal-age-irrespective-of-parity-a-population-based-register-study
#3
Ulla Waldenström, Cecilia Ekéus
BACKGROUND: Obstetric anal sphincter injury (OASI) is a rare but serious outcome of vaginal birth. Based on concerns about the increasing number of women who commence childbearing later than previous generation, this study aimed at investigating age-related risk of OASI in women of different parity. METHODS: A population-based register study including 959,559 live singleton vaginal births recorded in the Swedish Medical Birth Register 1999 to 2011. In each parity group risks of OASI at age 25-29 years, 30-34 years, and ≥35 years compared with age < 25 years were investigated by logistic regression analyses, adjusted for year of birth, education, region of birth, smoking, Body Mass Index, infant birthweight and fetal presentation; and in parous women, history of OASI and cesarean section...
September 15, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28914706/long-term-sexual-function-after-obstetric-anal-sphincter-injuries
#4
Michele S OʼShea, Christina Lewicky-Gaupp, Dana R Gossett
OBJECTIVES: Obstetric anal sphincter injuries (OASIS) are associated with severe short and long-term morbidities, although little is known about the long-term sexual function or satisfaction of women and partners of women with history of OASIS. The objective of this study was to describe the long-term sexual function and satisfaction of women who previously sustained OASIS and to assess sexual satisfaction among their male partners. METHODS: This was a follow-up study of participants enrolled in the For Optimal Recovery: Care After Severe Tears (FORCAST) prospective cohort study of women with a history of OASIS after delivery of a full-term singleton infant between 2011 and 2013...
September 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28914589/hplc-dad-method-development-and-validation-for-the-quantification-of-hydroxymethylfurfural-in-corn-chips-by-means-of-response-surface-optimization
#5
Sara Salvatierra Virgen, Silvia Guillermina Ceballos-Magaña, Vilma Del Carmen Salvatierra-Stamp, Maria Teresa Sumaya-Martínez, Francisco Javier Martínez-Martínez, Roberto Muñiz-Valencia
In recent years, there has been an increased concern about the presence of toxic compounds derived from the Maillard reaction produced during food cooking at high temperatures. The main toxic compounds derived from this reaction are acrylamide and hydroxymethylfurfural (HMF). The majority of analytical methods require sample treatments using solvents which are highly polluting for the environment. The difficulty for quantifying HMF in complex fried food matrices encourages the development of new analytical methods...
September 15, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28910965/actinobacteria-phylogenomics-selective-isolation-from-an-iron-oligotrophic-environment-and-siderophore-functional-characterization-unveil-new-desferrioxamine-traits
#6
Pablo Cruz-Morales, Hilda E Ramos-Aboites, Cuauhtémoc Licona-Cassani, Nelly Selem-Mójica, Paulina M Mejía-Ponce, Valeria Souza-Saldívar, Francisco Barona-Gómez
Desferrioxamines are hydroxamate siderophores widely conserved in both aquatic and soil-dwelling Actinobacteria. While the genetic and enzymatic bases of siderophore biosynthesis and their transport in model families of this phylum are well understood, evolutionary studies are lacking. Here, we perform a comprehensive desferrioxamine-centric (des genes) phylogenomic analysis, which includes the genomes of six novel strains isolated from an iron and phosphorous depleted oasis in the Chihuahuan desert of Mexico...
September 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28905931/jordan-seeks-to-become-an-oasis-of-water-saving-technology
#7
Amy Maxmen
No abstract text is available yet for this article.
September 13, 2017: Nature
https://www.readbyqxmd.com/read/28888927/the-effects-of-improving-sleep-on-mental-health-oasis-a-randomised-controlled-trial-with-mediation-analysis
#8
Daniel Freeman, Bryony Sheaves, Guy M Goodwin, Ly-Mee Yu, Alecia Nickless, Paul J Harrison, Richard Emsley, Annemarie I Luik, Russell G Foster, Vanashree Wadekar, Christopher Hinds, Andrew Gumley, Ray Jones, Stafford Lightman, Steve Jones, Richard Bentall, Peter Kinderman, Georgina Rowse, Traolach Brugha, Mark Blagrove, Alice M Gregory, Leanne Fleming, Elaine Walklet, Cris Glazebrook, E Bethan Davies, Chris Hollis, Gillian Haddock, Bev John, Mark Coulson, David Fowler, Katherine Pugh, John Cape, Peter Moseley, Gary Brown, Claire Hughes, Marc Obonsawin, Sian Coker, Edward Watkins, Matthias Schwannauer, Kenneth MacMahon, A Niroshan Siriwardena, Colin A Espie
BACKGROUND: Sleep difficulties might be a contributory causal factor in the occurrence of mental health problems. If this is true, improving sleep should benefit psychological health. We aimed to determine whether treating insomnia leads to a reduction in paranoia and hallucinations. METHODS: We did this single-blind, randomised controlled trial (OASIS) at 26 UK universities. University students with insomnia were randomly assigned (1:1) with simple randomisation to receive digital cognitive behavioural therapy (CBT) for insomnia or usual care, and the research team were masked to the treatment...
September 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28878801/crispr-cas9-a-practical-approach-in-date-palm-genome-editing
#9
REVIEW
Muhammad N Sattar, Zafar Iqbal, Muhammad N Tahir, Muhammad S Shahid, Muhammad Khurshid, Abdullatif A Al-Khateeb, Suliman A Al-Khateeb
The genetic modifications through breeding of crop plants have long been used to improve the yield and quality. However, precise genome editing (GE) could be a very useful supplementary tool for improvement of crop plants by targeted genome modifications. Various GE techniques including ZFNs (zinc finger nucleases), TALENs (transcription activator-like effector nucleases), and most recently clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 (CRISPR-associated protein 9)-based approaches have been successfully employed for various crop plants including fruit trees...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28873094/analysis-of-water-level-variation-of-lakes-and-reservoirs-in-xinjiang-china-using-icesat-laser-altimetry-data-2003-2009
#10
Zhaoxia Ye, Hongxing Liu, Yaning Chen, Song Shu, Qiusheng Wu, Shujie Wang
This study utilizes ICESat Release 33 GLA14 data to analyse water level variation of Xinjiang's lakes and reservoirs from 2003 to 2009. By using Landsat images, lakes and reservoirs with area larger than 1 km2 are numerically delineated with a software tool. Based on ICESat observations, we analyse the characteristics of water level variation in different geographic environments, as well as investigate the reasons for the variation. Results indicate that climatic warming contributes to rising water levels in lakes in mountainous areas, especially for lakes that are recharged by snow and glacial melting...
2017: PloS One
https://www.readbyqxmd.com/read/28861680/image-retrieval-based-on-local-mesh-vector-co-occurrence-pattern-for-medical-diagnosis-from-mri-brain-images
#11
A Jenitta, R Samson Ravindran
In modern health-care, for evidence-based diagnosis, there is a requirement for an efficient image retrieval approach to retrieve the cases of interest that have similar characteristics from the large image databases. This paper presents a feature extraction approach that aims at extracting texture features present in the medical images using Local Pattern Descriptor (LPD) and Gray-level Co-occurrence Matrix (GLCM). As a main contribution, a novel local pattern named Local Mesh Vector Co-occurrence Pattern (LMVCoP) has been proposed by concatenating the Local Mesh Co-occurrence Pattern (LMCoP) and the Local Vector Co-occurrence Pattern (LVCoP)...
August 31, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28852783/determination-of-fluoroquinolones-in-fish-tissues-biological-fluids-and-environmental-waters-by-liquid-chromatography-tandem-mass-spectrometry
#12
Haizea Ziarrusta, Nahia Val, Haizea Dominguez, Leire Mijangos, Ailette Prieto, Aresatz Usobiaga, Nestor Etxebarria, Olatz Zuloaga, Maitane Olivares
This work describes the optimization, validation, and application in real samples of accurate and precise analytical methods to determine ten fluoroquinolones (FQs) (norfloxacin, enoxacin, pefloxacin, ofloxacin, levofloxacin, ciprofloxacin, danofloxacin, lomefloxacin, enrofloxacin, and sparfloxacin) in different environmental matrices, such as water (estuarine, seawater, and wastewater treatment plant effluent), fish tissues (muscle and liver), and fish biofluids (plasma and bile). The analysis step performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was fully optimized to improve the separation and detection steps...
August 29, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28840630/the-music-therapy-session-assessment-scale-mt-sas-validation-of-a-new-tool-for-music-therapy-process-evaluation
#13
Alfredo Raglio, Marco Gnesi, Maria Cristina Monti, Osmano Oasi, Marta Gianotti, Lapo Attardo, Giulia Gontero, Lara Morotti, Sara Boffelli, Chiara Imbriani, Cristina Montomoli, Marcello Imbriani
BACKGROUND: Music therapy (MT) interventions are aimed at creating and developing a relationship between patient and therapist. However, there is a lack of validated observational instruments to consistently evaluate the MT process. AIM: The purpose of this study was the validation of Music Therapy Session Assessment Scale (MT-SAS), designed to assess the relationship between therapist and patient during active MT sessions. METHODS: Videotapes of a single 30-min session per patient were considered...
August 25, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28825647/alzheimer-s-disease-early-diagnosis-using-manifold-based-semi-supervised-learning
#14
Moein Khajehnejad, Forough Habibollahi Saatlou, Hoda Mohammadzade
Alzheimer's disease (AD) is currently ranked as the sixth leading cause of death in the United States and recent estimates indicate that the disorder may rank third, just behind heart disease and cancer, as a cause of death for older people. Clearly, predicting this disease in the early stages and preventing it from progressing is of great importance. The diagnosis of Alzheimer's disease (AD) requires a variety of medical tests, which leads to huge amounts of multivariate heterogeneous data. It can be difficult and exhausting to manually compare, visualize, and analyze this data due to the heterogeneous nature of medical tests; therefore, an efficient approach for accurate prediction of the condition of the brain through the classification of magnetic resonance imaging (MRI) images is greatly beneficial and yet very challenging...
August 20, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28822013/biomonitoring-of-chemicals-in-biota-of-two-wetland-protected-areas-exposed-to-different-levels-of-environmental-impact-results-of-the-previeni-project
#15
Cristiana Guerranti, Guido Perra, Eva Alessi, Davide Baroni, Dante Caserta, Donatella Caserta, Augusto De Sanctis, Emiliano Leonida Fanello, Cinzia La Rocca, Michela Mariottini, Monia Renzi, Sabrina Tait, Carlo Zaghi, Alberto Mantovani, Silvano Ettore Focardi
The PREVIENI project (funded by the Ministry of Environment) investigated the exposure to endocrine disrupters in samples of human population and environmental biota in Italy. The environmental biomonitoring considered two Italian WWF Oasis, with the aim to compare the presence and effects of endocrine disruptors in organisms from two protected natural areas, respectively, upstream and downstream a chemical emission site. Chemical analysis of pollutants' tissue levels was made on tissues from earthworm, barbell, trout, and coot, selected as bioindicator organisms...
August 18, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28818731/association-between-severities-of-striae-gravidarum-and-obstetric-anal-sphincter-injuries-oasis
#16
Ofra Halperin, Anita Noble, Shosh Balachsan, Ester Klug, Michal Liebergall-Wischnitzer
OBJECTIVES: to examine the association between the severities of Striae Gravidarum (SG) and Obstetric Anal Sphincter Injuries (OASIS) and to measure the symptoms regarding urinary incontinence, fecal/flatus incontinence, and dyspareunia, at 6 and 12 months postpartum. DESIGN: this is a cohort study. SETTING: four university teaching medical centers in Israel, two in the north and two in the center of the country. PARTICIPANTS: women with OASIS were interviewed and assessed for SG...
November 2017: Midwifery
https://www.readbyqxmd.com/read/28817112/monoallelic-and-biallelic-creb3l1-variant-causes-mild-and-severe-osteogenesis-imperfecta-respectively
#17
Rachel B Keller, Thao T Tran, Shawna M Pyott, Melanie G Pepin, Ravi Savarirayan, George McGillivray, Deborah A Nickerson, Michael J Bamshad, Peter H Byers
PurposeOsteogenesis imperfecta (OI) is a heritable skeletal dysplasia. Dominant pathogenic variants in COL1A1 and COL1A2 explain the majority of OI cases. At least 15 additional genes have been identified, but those still do not account for all OI phenotypes that present. We sought the genetic cause of mild and lethal OI phenotypes in an unsolved family.MethodsWe performed exome sequencing on seven members of the family, both affected and unaffected.ResultsWe identified a variant in cyclic AMP responsive element binding protein 3-like 1 (CREB3L1) in a consanguineous family...
August 17, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28815371/-side-effects-of-modernity-dam-building-health-care-and-the-construction-of-power-in-the-context-of-the-control-of-schistosomiasis-in-egypt-in-the-1960s-and-early-1970s
#18
Benjamin Brendel
This article analyzes the modernization campaigns in Egypt in the 1960s and early 1970s. The regulation of the Nile by the Aswan High Dam and the resulting irrigation projects caused the rate of schistosomiasis infestation in the population to rise. The result was a discourse between experts from the global north and Egyptian elites about modernization, development aid, dam building and health care. The fight against schistosomiasis was like a cipher, which combined different power-laden concepts and arguments...
August 16, 2017: NTM
https://www.readbyqxmd.com/read/28808332/magnetic-microsphere-based-portable-solid-phase-extraction-device-for-on-site-pre-concentration-of-organics-from-large-volume-water-samples
#19
Zhijian Yao, Qingqing Zhao, Yan Ma, Wei Wang, Qing Zhou, Aimin Li
In this research a new magnetic material called M88 was fully synthetized and characterized for the extraction of pharmaceutical and personal care products in water samples. In addition, a portable prototype of magnetic solidphase extraction (MSPE) device was developed for the onsite preconcentration. The MSPE coupling with high performance liquid chromatography-Diode array detector (HPLC-DAD) method was developed and validated for simultaneous analysis of 11 PPCPs (mefenamic acid, chloroamphenicol, ketoprofen, clofibric acid, indometacin, acetylsalicylic acid, bisphenol A, phenylphenol, gemfibrozil, triclosan, and ibuprofen) in environmental water samples...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806141/cutaneous-leishmaniasis-in-saudi-arabia-a-comprehensive-overview
#20
Abuzaid A Abuzaid, Abdalmohsin M Abdoon, Mohamed A Aldahan, Abdullah G Alzahrani, Raaft F Alhakeem, Abdullah M Asiri, Mohamed H Alzahrani, Ziad A Memish
Despite the great efforts by health authorities in Kingdom of Saudi Arabia (KSA), Cutaneous Leishmaniasis (CL) continues to be a major public health problem in the country. Many risk factors make KSA prone to outbreaks and epidemics; among these, rapid urbanization and the huge population movement are the most important. The disease is endemic in many parts of KSA, with the majority of cases concentrated in six regions, including Al-Qaseem, Riyadh, Al-Hassa, Aseer, Ha'il, and Al-Madinah. Leishmania major (L...
August 14, 2017: Vector Borne and Zoonotic Diseases
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