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https://www.readbyqxmd.com/read/28734908/why-transition-risk-to-psychosis-is-not-declining-at-the-oasis-ultra-high-risk-service-the-hidden-role-of-stable-pretest-risk-enrichment
#1
P Fusar-Poli, E Palombini, C Davies, D Oliver, I Bonoldi, V Ramella-Cravaro, P McGuire
BACKGROUND: The reason for declining risk to psychosis across individuals assessed and meeting Ultra High Risk (UHR) criteria is still unclear. No studies have investigated the potential substantial role of the underlying risk enrichment across all the individuals undergoing an UHR assessment. METHODS: Cohort study including all non-psychotic subjects who were assessed on suspicion of psychosis risk by the OASIS UHR service in the period 2001 to 2015. Posttest (after UHR assessment) and pretest risk (before UHR assessment) of psychosis were stratified and compared across three time periods (2001-2005, 2006-2010, 2011-2015) with Cox analysis and modulating factors were investigated...
July 19, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28727899/sacral-neuromodulation-for-combined-faecal-and-urinary-incontinence-following-obstetric-anal-sphincter-injury
#2
M Rydningen, Stine Riise, T Wilsgaard, R O Lindsetmo, S Norderval
AIM: The aim of this study was to investigate the efficacy of sacral neuromodulation (SNM) in the treatment of faecal incontinence and concomitant urinary incontinence in women with a history of obstetric anal sphincter injury (OASIS). METHOD: In this prospective study, consecutive women with faecal incontinence following OASIS accepted for SNM were screened for concomitant urinary incontinence. The primary outcome was the change in urinary incontinence score (ICIQ-UI-SF) between baseline and 12 months...
July 20, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28721483/the-effectiveness-of-mediolateral-episiotomy-in-preventing-obstetric-anal-sphincter-injuries-during-operative-vaginal-delivery-a-ten-year-analysis-of-a-national-registry
#3
Jeroen van Bavel, Chantal W P M Hukkelhoven, Charlotte de Vries, Dimitri N M Papatsonis, Joey de Vogel, Jan-Paul W R Roovers, Ben Willem Mol, Jan Willem de Leeuw
INTRODUCTION AND HYPOTHESIS: Obstetric anal sphincter injuries (OASIS) are associated with an increased risk of faecal incontinence after vaginal delivery. The aim of this retrospective population-based cohort study was to assess whether mediolateral episiotomy is associated with a reduction in the rate of OASIS during operative vaginal delivery. METHODS: We used data from the Dutch Perinatal Registry (Perined) that includes records of almost all births between 2000 and 2010 in The Netherlands...
July 18, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28718603/-long-term-consequences-of-obstetrical-anal-sphincter-injuries-on-sexual-function
#4
Maud De Rham, Sylvain Meyer, Chahin Achtari, Sandra Fornage
Obstetrical anal sphincter injuries (OASIS) can lead to sexual dysfunction. Literature is poor concerning long-term consequences of OASIS on female sexuality. The objective of this paper is to clarify long-term consequences of OASIS on sexual function. Dyspareunia and lubrication troubles are constantly reported based on articles reviewed in literature through Pubmed. Nevertheless, global sexual function seems not to be influenced by OASIS on a long-term basis. Therefore, sexual dysfunctions must be specifically analysed in women's follow-up after OASIS...
March 15, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28712568/the-discovery-of-wild-date-palms-in-oman-reveals-a-complex-domestication-history-involving-centers-in-the-middle-east-and-africa
#5
Muriel Gros-Balthazard, Marco Galimberti, Athanasios Kousathanas, Claire Newton, Sarah Ivorra, Laure Paradis, Yves Vigouroux, Robert Carter, Margareta Tengberg, Vincent Battesti, Sylvain Santoni, Laurent Falquet, Jean-Christophe Pintaud, Jean-Frédéric Terral, Daniel Wegmann
For many crops, wild relatives constitute an extraordinary resource for cultivar improvement [1, 2] and also help to better understand the history of their domestication [3]. However, the wild ancestor species of several perennial crops have not yet been identified. Perennial crops generally present a weak domestication syndrome allowing cultivated individuals to establish feral populations difficult to distinguish from truly wild populations, and there is frequently ongoing gene flow between wild relatives and the crop that might erode most genetic differences [4]...
July 8, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28710734/multi-class-determination-of-pharmaceuticals-in-wastewaters-by-solid-phase-extraction-and-liquid-chromatography-tandem-mass-spectrometry-with-matrix-effect-study
#6
Mirta Čizmić, Sandra Babić, Marija Kaštelan-Macan
In this work, a multi-class analytical method for determination of 22 frequently used pharmaceuticals was developed and validated. Analytes were from different classes for example macrolides, fluoroquinolones, tetracyclines, sulfonamides, anthelmintics, anesthetics, and others. Method was intended for analysis of aqueous samples so the sample preparation was done using solid-phase extraction (SPE). Different sorbents (C8, C18, polymeric, and ion exchange sorbents) combining different eluents (methanol, ethanol, acetonitrile, acetone, ethyl acetate) were investigated during development of sample preparation step...
July 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28709097/effects-of-land-use-and-climate-change-on-ecosystem-services-in-central-asia-s-arid-regions-a-case-study-in-altay-prefecture-china
#7
Qi Fu, Bo Li, Ying Hou, Xu Bi, Xinshi Zhang
The sustainable use of ecosystem services (ES) can contribute to enhancing human well-being. Understanding the effects of land use and climate change on ES can provide scientific and targeted guidance for the sustainable use of ES. The objective of this study was to reveal the way in which land use and climate change influence the spatial and temporal variations of ES in the mountain-oasis-desert system (MODS). In this study, we assessed water yield, soil conservation, crop production, and sand fixation in 1990, 2000, and 2010 in Altay Prefecture, which is representative of the MODS, based on widely used biophysical models...
July 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28699007/assessment-of-nonsteroidal-anti-inflammatory-drugs-by-ultrasonic-assisted-extraction-and-gc-ms-in-mgeni-and-msunduzi-river-sediments-kwazulu-natal-south-africa
#8
Bhekumuzi P Gumbi, Brenda Moodley, Grace Birungi, Patrick G Ndungu
The occurrence of eight pharmaceuticals was monitored during four seasons (spring, summer, autumn, and winter) along a 250-km stretch of the Msunduzi and Mgeni rivers in KwaZulu-Natal, South Africa. This paper describes an optimized method for the determination of nonsteroidal anti-inflammatory drugs (NSAIDs) in sediments. The method combines ultrasonic, centrifuge, and gas chromatography-mass spectrometry for the detection of these drugs in solid samples. Most of the parameters that affect the extraction step were optimized...
July 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28693101/monitoring-alkylphenols-in-water-using-the-polar-organic-chemical-integrative-sampler-pocis-determining-sampling-rates-via-the-extraction-of-pes-membranes-and-oasis-beads
#9
Ludovica Silvani, Carmela Riccardi, Espen Eek, Marco Petrangeli Papini, Nicolas A O Morin, Gerard Cornelissen, Amy M P Oen, Sarah E Hale
Polar organic chemical integrative samplers (POCIS) have previously been used to monitor alkylphenol (AP) contamination in water and produced water. However, only the sorbent receiving phase of the POCIS (Oasis beads) is traditionally analyzed, thus limiting the use of POCIS for monitoring a range of APs with varying hydrophobicity. Here a "pharmaceutical" POCIS was calibrated in the laboratory using a static renewal setup for APs (from 2-ethylphenol to 4-n-nonylphenol) with varying hydrophobicity (log Kow between 2...
June 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28693087/-quantitative-structure-activity-relationship-prediction-of-carcinogenicity-of-n-nitroso-compounds-based-on-category-approach-and-read-across
#10
Q Q Liang, W W Zheng, G S He, W D Qu
Objective: New quantitative structure-activity relationship (QSAR) method was used to predict N-nitroso compounds (NOCs) carcinogenicity. This could provide evidences for health risk assessment of the chemicals. Methods: Total 74 chemical substances of NOCs were included as target chemicals for this validation study by using QSAR Toolbox based on category approach and read-across. The included 74 NOCs were categorized and subcategorized respectively using "Organic functional groups, Norbert Haider " profiler and "DNA binding by OASIS V...
July 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28681174/risk-factors-for-obstetric-anal-sphincter-injuries-oasi-at-a-tertiary-centre-in-south-india
#11
Sirisha Rao Gundabattula, Kameswari Surampudi
INTRODUCTION AND HYPOTHESIS: Despite several studies that have reported risk factors for obstetric anal sphincter injuries (OASI), data from the Indian subcontinent are scarce. The purpose of this study was to identify risk factors for these sphincter injuries in an Indian population. METHODS: This was a case-control study within a retrospective cohort of vaginal deliveries at a tertiary care facility. All vaginal births beyond 24 completed weeks of gestation and birth weight ≥500 g from January 2008 to December 2012 were identified from the hospital electronic database...
July 5, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28678704/auto-context-convolutional-neural-network-auto-net-for-brain-extraction-in-magnetic-resonance-imaging
#12
Seyed Sadegh Mohseni Salehi, Deniz Erdogmus, Ali Gholipour
Brain extraction or whole brain segmentation is an important first step in many of the neuroimage analysis pipelines. The accuracy and robustness of brain extraction, therefore, is crucial for the accuracy of the entire brain analysis process. State-of-the-art brain extraction techniques rely heavily on the accuracy of alignment or registration between brain atlases and query brain anatomy, and/or make assumptions about the image geometry; therefore have limited success when these assumptions do not hold or image registration fails...
June 28, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28668369/evaluation-of-a-multiresidue-capillary-electrophoresis-quadrupole-time-of-flight-mass-spectrometry-method-for-the-determination-of-antibiotics-in-milk-samples
#13
David Moreno-González, Ahmed M Hamed, Bienvenida Gilbert-López, Laura Gámiz-Gracia, Ana M García-Campaña
A selective and rapid method has been developed to determine 15 antibiotic residues (eight tetracyclines and seven quinolones) in milk samples by capillary zone electrophoresis coupled with quadrupole time-of-flight mass spectrometry (CZE-Q-TOF-MS). The use of this hybrid mass spectrometer allowed obtaining full scan and full MS/MS spectra for quantification/confirmation purposes in a single run. In addition, solid phase extraction (SPE) using the new Oasis PRiME HLB cartridge was proposed for the extraction, achieving excellent results in terms of sample throughput...
August 11, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28661171/utility-of-the-mmpi-2-restructured-form-mmpi-2-rf-in-a-sample-of-lithuanian-male-offenders
#14
Ilona Laurinaitytė, Alfredas Laurinavičius, Laura Ustinavičiūtė, Dustin B Wygant, Martin Sellbom
The aim of the current study was to examine the construct validity of the Multiphasic Personality Inventory-2 Restructured Form (Minnesota Multiphasic Personality Inventory [MMPI]-2-RF; Ben-Porath & Tellegen, 2008/2011) in a correctional setting. More specifically, we examined the associations between MMPI-2-RF scales with external variables relevant for sentence planning as well as the relationship with risk of reconviction assessed with the Offender Assessment System (OASys; Home Office, 2002). A random sample of 228 male offenders from Lithuanian custodial institutions was selected for the study...
June 29, 2017: Law and Human Behavior
https://www.readbyqxmd.com/read/28659509/the-impact-of-self-directed-voice-of-love-messages-on-anger-a-pilot-study
#15
Arie Tzvieli, Tamar Zaig, Igal Ayal, Gil Thieberger, Sarit Rothschild, Yoram Barak
Context • Buddhist texts direct practitioners to generate a feeling of love to stop the affliction of anger. Modern self-help practices and clinical psychology have demonstrated that generating emotions of love can reduce anger. More studies are needed, however, to identify the active components of interventions and their applicability in clinical populations. Objective • The study investigated the hypothesis that enhancing self-love through frequent listening to recorded self-loving messages can reduce anger...
April 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/28654086/a-multiscale-dataset-for-understanding-complex-eco-hydrological-processes-in-a-heterogeneous-oasis-system
#16
Xin Li, Shaomin Liu, Qin Xiao, Mingguo Ma, Rui Jin, Tao Che, Weizhen Wang, Xiaoli Hu, Ziwei Xu, Jianguang Wen, Liangxu Wang
We introduce a multiscale dataset obtained from Heihe Watershed Allied Telemetry Experimental Research (HiWATER) in an oasis-desert area in 2012. Upscaling of eco-hydrological processes on a heterogeneous surface is a grand challenge. Progress in this field is hindered by the poor availability of multiscale observations. HiWATER is an experiment designed to address this challenge through instrumentation on hierarchically nested scales to obtain multiscale and multidisciplinary data. The HiWATER observation system consists of a flux observation matrix of eddy covariance towers, large aperture scintillometers, and automatic meteorological stations; an eco-hydrological sensor network of soil moisture and leaf area index; hyper-resolution airborne remote sensing using LiDAR, imaging spectrometer, multi-angle thermal imager, and L-band microwave radiometer; and synchronical ground measurements of vegetation dynamics, and photosynthesis processes...
June 27, 2017: Scientific Data
https://www.readbyqxmd.com/read/28628863/simultaneous-quantification-of-endothelin-receptor-antagonists-and-phosphodiesterase-5-inhibitors-currently-used-in-pulmonary-arterial-hypertension
#17
Yeliz Enderle, Lukas Witt, Heinrike Wilkens, Ekkehard Grünig, Walter E Haefeli, Jürgen Burhenne
Combination treatment with endothelin receptor antagonists (ERA) and phosphodiesterase 5 inhibitors (PDE5I) improved efficacy of pulmonary arterial hypertension (PAH) therapy. However, drug-drug interactions, variable exposure, non-adherence can influence plasma levels. For these reasons, drug quantification may be advantageous particularly in patients with poor treatment responses. We developed, validated, and applied an assay for the simultaneous quantification of ambrisentan, bosentan, macitentan, sildenafil, and tadalafil as well as their main (and partly active) metabolites in human plasma...
September 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28625676/comprehensive-determination-of-macrolide-antibiotics-their-synthesis-intermediates-and-transformation-products-in-wastewater-effluents-and-ambient-waters-by-liquid-chromatography-tandem-mass-spectrometry
#18
Ivan Senta, Ivona Krizman-Matasic, Senka Terzic, Marijan Ahel
Macrolide antibiotics are a prominent group of emerging contaminants frequently found in wastewater effluents and wastewater-impacted aquatic environments. In this work, a novel analytical method for simultaneous determination of parent macrolide antibiotics (azithromycin, erythromycin, clarithromycin and roxithromycin), along with their synthesis intermediates, byproducts, metabolites and transformation products in wastewater and surface water was developed and validated. Samples were enriched using solid-phase extraction on Oasis HLB cartridges and analyzed by reversed-phase liquid chromatography coupled to electrospray ionization tandem mass spectrometry...
August 4, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28623864/a-highly-sensitive-lc-ms-ms-method-for-simultaneous-determination-of-glycyrrhizin-and-its-active-metabolite-glycyrrhetinic-acid-application-to-a-human-pharmacokinetic-study-after-oral-administration
#19
Tsuneharu Suzuki, Michiko Tsukahara, Yuko Akasaka, Hideo Inoue
A highly sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of glycyrrhizin (GL) and its active metabolite, glycyrrhetinic acid (GA) from human plasma was validated and applied to a human pharmacokinetic study. The analytes were extracted from human plasma using an Oasis MAX cartridge and chromatographic separation was performed on an Inertsil ODS-3 column. The detection was performed using an API 4000 mass spectrometer operating in the positive electrospray ionization mode...
June 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28619486/extended-depth-of-focus-contact-lenses-vs-two-commercial-multifocals-part-2-visual-performance-after-1-week-of-lens-wear
#20
Ravi C Bakaraju, Daniel Tilia, Jennifer Sha, Jennie Diec, Jiyoon Chung, Danny Kho, Shona Delaney, Anna Munro, Varghese Thomas
PURPOSE: To compare the visual performance of prototype contact lenses designed via deliberate manipulation of higher-order spherical aberrations to extend-depth-of-focus with two commercial multifocals, after 1 week of lens wear. METHODS: In a prospective, participant-masked, cross-over, randomized, 1-week dispensing clinical-trial, 43 presbyopes [age: 42-63 years] each wore AIROPTIX Aqua multifocal (AOMF), ACUVUE OASYS for presbyopia (AOP) and extended-depth-of-focus prototypes (EDOF) appropriate to their add requirements...
June 12, 2017: Journal of Optometry
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