keyword
https://read.qxmd.com/read/37689763/anti-atopic-dermatitis-effect-of-fish-collagen-on-house-dust-mite-induced-mice-and-hacat-keratinocytes
#21
JOURNAL ARTICLE
Hye-Min Kim, Bo-Ram Jin, Jin-Sil Lee, Eun Heui Jo, Min Cheol Park, Hyo-Jin An
Collagen, a major structural protein in mammalian tissues, is effective against skin wounds and osteoarthritis. Although bovine and porcine collagens have mainly been used, several potential risks of mammalian collagen have led to the use of fish collagen (FC) as an alternative. FC and its peptides are used as common cosmeceutical products because of their antihypertensive, anti-bacterial, and antioxidant activities. Despite the effects of FC on wrinkle reduction, UV-protection, and wound healing, the relationship between FC and atopic dermatitis (AD) has not yet been reported...
September 9, 2023: Scientific Reports
https://read.qxmd.com/read/37675143/non-ige-reactive-allergen-peptides-deteriorate-the-skin-barrier-in-house-dust-mite-sensitized-atopic-dermatitis-patients
#22
JOURNAL ARTICLE
Karin Pfisterer, Matthias Wielscher, David Samardzic, Pauline Weinzettl, Dorte Symmank, Lisa E Shaw, Raffaela Campana, Huey-Jy Huang, Matthias Farlik, Christine Bangert, Susanne Vrtala, Rudolf Valenta, Wolfgang Weninger
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by type 2 cytokine-driven skin inflammation and epithelial barrier dysfunction. The latter is believed to allow the increased penetration of chemicals, toxins, and allergens into the skin. House dust mite allergens, particularly Der p 2, are important triggers in sensitized individuals with AD; the precise actions of these allergens in epithelial biology remain, however, incompletely understood. In this study, we compared the effects of the protein allergen Der p 2 and a mix of non-IgE-reactive Der p 2 peptides on skin cells using patch tests in AD patients and healthy participants...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/37670127/inhibitory-effect-of-sanguisorba-hakusanensis-makino-ethanol-extract-on-atopic-dermatitis-like-responses-in-nc-nga-mice-and-human-keratinocytes
#23
JOURNAL ARTICLE
Hyun-Kyung Song, Sun Haeng Park, Hye Jin Kim, Seol Jang, Byung-Kil Choo, Ho Kyoung Kim, Taesoo Kim
Atopic dermatitis (AD) is an allergic, inflammatory skin disease caused by immune dysregulation. In this study, we investigated anti-atopic and anti-inflammatory activities of Sanguisorba hakusanensis ethanol extract (SHE) both in vivo using NC/Nga mice and in vitro using human HaCaT keratinocytes. Oral administration of SHE suppressed several atopic symptoms associated with house dust mites (induced with Dermatophagoides farinae extract) in NC/Nga mice and decreased serum levels of inflammatory mediators such as immunoglobulin E, histamine, and inflammatory chemokines...
September 5, 2023: Scientific Reports
https://read.qxmd.com/read/37650473/tnf-like-weak-inducer-of-apoptosis-inhibition-is-comparable-to-il-13-blockade-in-ameliorating-atopic-dermatitis-inflammation
#24
JOURNAL ARTICLE
Rinkesh K Gupta, Jacqueline Miller, Michael Croft
BACKGROUND: Targeting IL-13 is highly efficacious in patients with Th2-biased atopic dermatitis (AD), but inhibition of other inflammatory molecules might also limit disease. We investigated the importance of the TNF family cytokine TNF-like weak inducer of apoptosis (TWEAK; TNFSF12) to keratinocyte dysregulation and the pathogenesis of AD in mice and also tested if blocking TWEAK has a similar therapeutic effect as targeting IL-13. METHODS: Conditional knockout mice lacking Fn14 (TNFRSF12A), the receptor for TWEAK, only in keratinocytes, were repetitively sensitized with house dust mite allergen and analyzed for AD-like skin inflammation...
August 31, 2023: Allergy
https://read.qxmd.com/read/37624299/immunolocalization-and-expression-of-jak1-and-jak3-in-the-skin-of-dust-mite-sensitive-beagle-dogs-before-and-after-allergen-exposure
#25
JOURNAL ARTICLE
Roberta Sartori, Kim Ahrens, Rachel Wilkes, Rosanna Marsella
Janus kinase (JAK) pathways have emerged as targets of treatment, yet localization and expression of JAK1 and JAK3 in canine atopic skin have not been studied. This study aimed to compare the localization and expression of JAK1 and JAK3 in the skin of atopic dogs before and after allergen exposure. Skin biopsies taken from atopic beagles sensitized to house dust mites (HDM) before (D0) and after four weeks (D28) of allergen exposure were stained. Staining was subjectively scored by examiners unaware of the source of the slides...
August 8, 2023: Veterinary Sciences
https://read.qxmd.com/read/37498896/indoor-aeroallergens-from-american-cockroaches-and-mites-initiate-atopic-march-via-cutaneous-contact-in-a-murine-model
#26
JOURNAL ARTICLE
Mey-Fann Lee, Yu-Wen Chu, Chi-Sheng Wu, Ming-Hao Lee, Yi-Hsing Chen, Nancy M Wang
The progression of allergic diseases from atopic dermatitis in childhood to other allergic conditions such as asthma in later life is often referred to as the atopic march. In order to study the relationship between cutaneous sensitization by aeroallergen and atopic march, we established a mouse model to test the hypothesis using American cockroaches and house dust mites as the model allergens. Mice were sensitized via skin with native cockroach extract (CraA) or recombinant Per a 2 and Der p 2 proteins without adjuvant...
2023: PloS One
https://read.qxmd.com/read/37445644/molecular-mapping-of-allergen-exposome-among-different-atopic-phenotypes
#27
JOURNAL ARTICLE
Ruperto González-Pérez, Paloma Poza-Guedes, Fernando Pineda, Tania Galán, Elena Mederos-Luis, Eva Abel-Fernández, María José Martínez, Inmaculada Sánchez-Machín
Climate change and exposure to environmental pollutants play a key role in the onset and aggravation of allergic diseases. As different climate-dependent patterns of molecular immunoglobulin E (IgE) reactivity have been regionally described, we sought to investigate the evolving allergen exposome in distinctive allergic phenotypes and subtropical weather conditions through a Precision Allergy Molecular Diagnosis (PAMD@) model. Concurrent sensitization to several house dust mites (HDM) and storage mite molecules were broadly dominant in the investigated cohort, followed by the major cat allergen Fel d 1, and regardless of the basal allergic disease...
June 21, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37423284/effects-of-indoor-air-quality-and-home-environmental-characteristics-on-allergic-diseases-among-preschool-children-in-the-greater-taipei-area
#28
JOURNAL ARTICLE
Hsiao-Chun Huang, Ming-Lun Zou, Yi-Hua Chen, Chuen-Bin Jiang, Chih-Da Wu, Shih-Chun Candice Lung, Ling-Chu Chien, Yu-Chun Lo, Hsing Jasmine Chao
Indoor air quality and home environmental characteristics are potential factors associated with the onset and exacerbation of allergic diseases. Our study examined the effects of these factors on allergic diseases (i.e., asthma, allergic rhinitis, allergic conjunctivitis, and atopic dermatitis) among preschool children. We recruited a total of 120 preschool children from an ongoing birth cohort study in the Greater Taipei Area. A comprehensive environmental evaluation was conducted at each participant's residence and included measurements of indoor and outdoor air pollutants, fungal spores, endotoxins, and house dust mite allergens...
July 7, 2023: Science of the Total Environment
https://read.qxmd.com/read/37422783/factors-associated-with-allergic-rhinitis-and-combined-allergic-rhinitis-and-asthma-syndrome-caras-in-adults-undergoing-immunotherapy-in-a-tropical-country-is-isaac-iii-questionnaire-useful-in-adult-populations
#29
JOURNAL ARTICLE
Augusto Peñaranda, Lucía C Pérez-Herrera, Manuela Gantiva, Sergio Moreno-López, Julian Manrique, Daniel Peñaranda, Elizabeth García
BACKGROUND: Allergic diseases affect about 10-30% of the population in low- or middle-income tropical countries. Few studies describe the factors associated with allergic diseases in adult patients undergoing immunotherapy in Latin American countries. OBJECTIVE: This study aimed to determine the factors associated with allergic rhinitis (AR) and AR in comorbidity with asthma (CARAS) in adults treated with immunotherapy in two allergy referral centers in Bogotá (Colombia)...
2023: Allergologia et Immunopathologia
https://read.qxmd.com/read/37393903/a-dietary-pattern-for-high-estimated-total-fat-amount-is-associated-with-enhanced-allergy-sensitization-and-atopic-diseases-among-singapore-malaysia-young-chinese-adults
#30
JOURNAL ARTICLE
Jun Jie Lim, Kavita Reginald, Yee-How Say, Mei Hui Liu, Fook Tim Chew
INTRODUCTION: Frequent dietary patterns for fast food diets are suggested to be a risk factor for atopic disease development. Excessive dietary fats in fast foods are postulated to promote low-grade chronic inflammation. However, no studies in Asia have yet to characterize the dietary pattern for high-fat foods with atopic diseases. Thus, this study aims to assess the association between dietary fats with the prevalence of atopic diseases in an allergic cohort. METHODS: Through an investigator-administered questionnaire that follows the International Study of Asthma and Allergies in Childhood (ISAAC) protocol, we evaluated the eating habits, lifestyle behaviours, sociodemographics, and atopic symptoms, and history among 11,494 young Chinese adults in Singapore and Malaysia...
June 30, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/37382082/pilot-study-to-determine-the-concordance-between-skin-prick-and-intradermal-test-idt-reactivity-to-environmental-allergens-in-atopic-dogs-using-idt-as-the-gold-standard
#31
JOURNAL ARTICLE
Drew A Fleischman, Daniel O Morris
BACKGROUND: Prick testing is widely used as the first-line in vivo test for environmental allergens in people owing to its noninvasive nature and speed of performance. OBJECTIVES: To determine concordance between skin prick testing (SPT) and intradermal testing (IDT) reactivity to environmental allergen mixes in dogs with atopic dermatitis (cAD). ANIMALS: Forty client-owned dogs with cAD. MATERIALS AND METHODS: Skin prick testing (GREER Pick System; Stallergenes Greer) and IDT were performed on 40 dogs using seven glycerinated and aqueous environmental allergen mixes, respectively (tree, grass and weed pollens, house dust mites and three mould mixes)...
June 29, 2023: Veterinary Dermatology
https://read.qxmd.com/read/37366209/sensitization-trajectories-to-multiple-allergen-components-in-a-population-based-birth-cohort
#32
JOURNAL ARTICLE
Mariana Farraia, Francisca Castro Mendes, Oksana Sokhatska, Milton Severo, João Cavaleiro Rufo, Henrique Barros, André Moreira
BACKGROUND: The characteristics of allergic sensitization profiles can differ between populations and geographic regions, contributing differently to the association with allergic diseases. Consequently, the sensitization trajectories found in previous studies conducted in Northern Europe may not apply in Southern European countries. OBJECTIVE: To identify trajectories of allergic sensitization profiles during childhood and evaluate the association with allergic outcomes, using data from a Portuguese birth cohort...
June 2023: Pediatric Allergy and Immunology
https://read.qxmd.com/read/37298186/ceramide-ad%C3%A2-restores-skin-integrity-and-function-following-exposure-to-house-dust-mite
#33
JOURNAL ARTICLE
Hanene Bzioueche, Myriam Tamelghaghet, Bérengère Chignon-Sicard, Noémie Bazile, Pauline Hauchecorne, Maria Barbero Calderón, Pauline Meunier, Stéphane Rocchi, Thierry Passeron, Meri K Tulic
Ceramides are epidermal lipids important for normal skin barrier function. Reduced Ceramide content is associated with atopic dermatitis (AD). House dust mite (HDM) has been localized in AD skin where it plays an exacerbator role. We set to examine the impact of HDM on skin integrity and the effect of three separate Ceramides (AD™, DS, Y30) on HDM-induced cutaneous damage. The effect was tested in vitro on primary human keratinocytes and ex vivo on skin explants. HDM (100 μg/mL) decreased the expression of adhesion protein E-cadherin, supra-basal (K1, K10) and basal (K5, K14) keratins and increased matrix metallopeptidase (MMP)-9 activity...
May 25, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37248786/allergen-specific-immunotherapy-improves-alopecia-totalis-in-a-severe-atopic-dermatitis-patient
#34
JOURNAL ARTICLE
Il Joo Kwon, Jung Won Park, Su Min Kim, Kwang Hoon Lee, Chang Ook Park
House dust mite (HDM) is the most common allergen exacerbating atopic dermatitis (AD), and allergen-specific immunotherapy (AIT) using HDM exhibited significant improvements in previous studies. Alopecia can occur as a complication of AD. Alopecia totalis (AT), a severe form of alopecia areata (AA), does not respond well to treatment and the chance of full recovery is less than 10%. For extensive hair loss, topical immunotherapy such as diphenylcyclopropenone (DPCP) is used as the first-line treatment. However, since DPCP is a kind of contact allergen, it has the potential to exacerbate AD...
October 2023: Journal of Dermatology
https://read.qxmd.com/read/37208336/impaired-expression-of-metallothioneins-contributes-to-allergen-induced-inflammation-in-patients-with-atopic-dermatitis
#35
JOURNAL ARTICLE
Sofia Sirvent, Andres F Vallejo, Emma Corden, Ying Teo, James Davies, Kalum Clayton, Eleanor G Seaby, Chester Lai, Sarah Ennis, Rfeef Alyami, Gemma Douilhet, Lareb S N Dean, Matthew Loxham, Sarah Horswill, Eugene Healy, Graham Roberts, Nigel J Hall, Peter S Friedmann, Harinder Singh, Clare L Bennett, Michael R Ardern-Jones, Marta E Polak
Regulation of cutaneous immunity is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic dermatitis, we utilise a human in vivo allergen challenge study, exposing atopic dermatitis patients to house dust mite. Here we analyse transcriptional programmes at the population and single cell levels in parallel with immunophenotyping of cutaneous immunocytes revealed a distinct dichotomy in atopic dermatitis patient responsiveness to house dust mite challenge...
May 19, 2023: Nature Communications
https://read.qxmd.com/read/37181420/observational-study-of-pimecrolimus-1-cream-for-prevention-of-transcutaneous-sensitization-in-children-with-atopic-dermatitis-during-their-first-year-of-life
#36
JOURNAL ARTICLE
Nikolay N Murashkin, Leyla S Namazova-Baranova, Svetlana G Makarova, Roman A Ivanov, Stepan G Grigorev, Dmitri V Fedorov, Eduard T Ambarchian, Roman V Epishev, Alexander I Materikin, Leonid A Opryatin, Alena A Savelova
INTRODUCTION: Epidermal barrier dysfunction in children with atopic dermatitis can cause transcutaneous sensitization to allergens and allergic diseases. We evaluated the effectiveness of an early-intervention algorithm for atopic dermatitis treatment, utilizing pimecrolimus for long-term maintenance therapy, in reducing transcutaneous sensitization in infants. METHOD: This was a single-center cohort observational study that enrolled children aged 1-4 months with family history of allergic diseases, moderate-to-severe atopic dermatitis, and sensitization to ≥ 1 of the investigated allergens...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37180108/serological-analysis-of-allergic-components-of-house-dust-mite-provides-more-insight-in-epidemiological-characteristics-and-clinical-symptom-development-in-north-china
#37
JOURNAL ARTICLE
Yi Liu, Lan Zhao, Jiaofeng Wang, Yinshi Guo, Yifei Wang, Lishan Zhang, Zhoujie Wu, Mingzhi Zhu, Xukai Yang, Puyang Xu, Shandong Wu, Zhongshan Gao, Jin-Lyu Sun
BACKGROUND: House dust mite (HDM) is the most common airborne source causing complex allergy symptoms. There are geographic differences in the allergen molecule sensitization profiles. Serological testing with allergen components may provide more clues for diagnosis and clinical management. OBJECTIVE: This study aims to investigate the sensitization profile of eight HDM allergen components in a large number of patients enrolled in the clinic and to analyze the relation of gender, age, and clinical symptoms in North China...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37140010/impact-of-house-dust-mite-in-vitiligo-skin-environmental-contribution-to-increased-cutaneous-immunity-and-melanocyte-detachment
#38
JOURNAL ARTICLE
Hanene Bzioueche, Katia Boniface, Claire Drullion, Sandrine Marchetti, Bérengère Chignon-Sicard, Laura Sormani, Stéphane Rocchi, Julien Senechal, Thierry Passeron, Meri K Tulic
BACKGROUND: Vitiligo is an autoimmune skin disorder characterized by loss of melanocytes. Protease-mediated disruption of junctions between keratinocytes and/or keratinocyte intrinsic dysfunction may directly contribute to melanocyte loss. House dust mite (HDM), an environmental allergen with potent protease activity, contributes to respiratory and gut disease but also to atopic dermatitis and rosacea. OBJECTIVE: To verify if HDM can contribute to melanocyte detachment in vitiligo and if so, by which mechanism(s)...
May 4, 2023: British Journal of Dermatology
https://read.qxmd.com/read/37134216/the-diagnostic-value-of-delayed-type-reactions-to-perennial-aeroallergens-for-atopic-disease
#39
JOURNAL ARTICLE
Puneet Arora, Rebecca L Freese, Paul L Bigliardi
<u> Background: </u> Delayed-type reactions to aeroallergens have been observed, however, their clinical significance continues to be debated. <u> Objective: </u> We assessed the prevalence and significance of delayed-type reactions to aeroallergens in atopic patients. <u> Methods: </u> Retrospective study including 266 patients with history or evidence of atopic disease (atopic dermatitis [AD], allergic rhinitis, and/or allergic asthma) and tested via either the intradermal skin test (IDT) or atopy patch test for common aeroallergens, specifically house dust mites ( Dermatophagoides farinae , Dermatophagoides pteronyssinus ) and perennial molds ( Aspergillus fumigatus , Penicillium notatum )...
May 3, 2023: Dermatitis
https://read.qxmd.com/read/37119758/house-dust-mite-allergy-the-importance-of-house-dust-mite-allergens-for-diagnosis-and-immunotherapy
#40
REVIEW
Huey-Jy Huang, Eszter Sarzsinszky, Susanne Vrtala
House dust mite (HDM) allergy belongs to the most important allergies and affects approximately 65-130 million people worldwide. Additionally, untreated HDM allergy may lead to the development of severe disease manifestations such as atopic dermatitis or asthma. Diagnosis and immunotherapy of HDM allergic patients are well established but are often hampered by the use of mite extracts that are of bad quality and lack important allergens. The use of individual allergens seems to be a promising alternative to natural allergen extracts, since they represent well-defined components that can easily be produced and quantified...
June 2023: Molecular Immunology
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