Sofia Sirvent, Andres F Vallejo, Emma Corden, Ying Teo, James Davies, Kalum Clayton, Eleanor G Seaby, Chester Lai, Sarah Ennis, Rfeef Alyami, Gemma Douilhet, Lareb S N Dean, Matthew Loxham, Sarah Horswill, Eugene Healy, Graham Roberts, Nigel J Hall, Peter S Friedmann, Harinder Singh, Clare L Bennett, Michael R Ardern-Jones, Marta E Polak
Regulation of cutaneous immunity is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic dermatitis, we utilise a human in vivo allergen challenge study, exposing atopic dermatitis patients to house dust mite. Here we analyse transcriptional programmes at the population and single cell levels in parallel with immunophenotyping of cutaneous immunocytes revealed a distinct dichotomy in atopic dermatitis patient responsiveness to house dust mite challenge...
May 19, 2023: Nature Communications