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house dust mite dermatitis

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https://www.readbyqxmd.com/read/29427643/new-mechanism-underlying-il-31-induced-atopic-dermatitis
#1
Jianghui Meng, Masaki Moriyama, Micha Feld, Joerg Buddenkotte, Timo Buhl, Attila Szöllösi, Jingming Zhang, Paul Miller, Andre Ghetti, Michael Fischer, Peter W Reeh, Chunxu Shan, Jiafu Wang, Martin Steinhoff
BACKGROUND: T helper type 2 cell-released interleukin 31 (IL-31) is a critical mediator in atopic dermatitis (AD), a prevalent and debilitating chronic skin disorder. Brain-derived natriuretic peptide (BNP) has been described as a central itch mediator. The importance of BNP in peripheral (skin-derived) itch and its functional link to IL-31 within the neuro-immune axis of the skin is unknown. OBJECTIVE: To investigate the function of BNP in the peripheral sensory system and skin in IL-31-induced itch and neuro-epidermal communication in AD...
February 7, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29339444/light-hvem-signaling-in-keratinocytes-controls-development-of-dermatitis
#2
Rana Herro, Jr-Wen Shui, Sonja Zahner, Daniel Sidler, Yuko Kawakami, Toshiaki Kawakami, Koji Tamada, Mitchell Kronenberg, Michael Croft
Dermatitis is often associated with an allergic reaction characterized by excessive type 2 responses leading to epidermal acanthosis, hyperkeratosis, and dermal inflammation. Although factors like IL-4, IL-13, and thymic stromal lymphopoietin (TSLP) are thought to be instrumental for the development of this type of skin disorder, other cytokines may be critical. Here, we show that the tumor necrosis factor (TNF) superfamily protein LIGHT (homologous to lymphotoxin, exhibits inducible expression, and competes with HSV glycoprotein D for binding to HVEM, a receptor expressed on T lymphocytes) is required for experimental atopic dermatitis, and LIGHT directly controls keratinocyte hyperplasia, and production of periostin, a matricellular protein that contributes to the clinical features of atopic dermatitis as well as other skin diseases such as scleroderma...
February 5, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29288652/co-activation-of-gr-and-ppar%C3%AE-in-murine-skin-prevents-worsening-of-atopic-march
#3
Julie Deckers, Nadia Bougarne, Viacheslav Mylka, Sofie Desmet, Astrid Luypaert, Michael Devos, Giel Tanghe, Justine Van Moorleghem, Manon Vanheerswynghels, Lode De Cauwer, Jonathan Thommis, Marnik Vuylsteke, Jan Tavernier, Bart Lambrecht, Hamida Hammad, Karolien De Bosscher
Children with atopic dermatitis (AD) show an increased risk to develop asthma later in life, a phenomenon referred to as 'atopic march', which emphasizes the need for secondary prevention therapies. This study aimed to investigate whether relief of skin inflammation by glucocorticoids and PPARγ-agonists might influence the subsequent development of asthma in a murine model for the atopic march in which mice were repeatedly exposed to house dust mite (HDM) via the skin, followed by exposure to HDM in lungs...
December 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29244180/seasonal-variation-of-allergenic-acarofauna-from-the-homes-of-allergic-rhinitis-and-asthmatic-patients
#4
Navpreet Kaur Gill, Amandeep Kaur Dhaliwal
House dust mites (HDMs) play positive role in causing various kinds of allergenic manifestations such as allergic rhinitis (AR), asthma, dermatitis, and urticaria. HDMs are prevalent in temperate regions but various studies have shown the prevalence of HDMs in tropical and subtropical countries. The present study was conducted from March 2015 to February 2016. During the study period, a total of 500 dust samples were collected from 125 homes of 125 patients suffering from AR and asthma. From these 500 dust samples, 466 samples were found to be positive for mites...
December 13, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29209493/comparison-of-atopy-patch-testing-to-skin-prick-testing-for-diagnosing-mite-induced-atopic-dermatitis-a-systematic-review-and-meta-analysis
#5
REVIEW
Yumei Liu, Jianglong Peng, Ying Zhou, Yubao Cui
Background: Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an important tool in the diagnosis of AD caused by house dust mites. Here, we present a meta-analysis comparing APT to the common skin prick test (SPT) in the diagnosis of mite-induced AD. Methods: A structured search was performed using online databases and bibliographies published as of April 30, 2017...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29158156/anti-allergic-effects-of-sesquiterpene-lactones-from-saussurea-costus-falc-lipsch-determined-using-in-vivo-and-in-vitro-experiments
#6
Bo-Kyung Lee, Soo-Jin Park, So-Yeon Nam, Saeromi Kang, Jin Hwang, Seung-Jin Lee, Dong-Soon Im
ETHNOPHARMACOLOGICAL RELEVANCE: Saussurea costus (Falc.) Lipsch. root has been used in Asian traditional medicine for the treatment of asthma, rheumatism, and other conditions. S. costus extracts were shown to alleviate house dust mite-induced atopic-like dermatitis in Nc/Nga mice; besides, sesquiterpene lactones were isolated from S. costus extracts. AIMS OF THE STUDY: We aimed to investigate the effects of sesquiterpene lactones (alantolactone, costunolide, and dehydrocostuslactone) in allergic asthma using female Balb/c mice and rat RBL-2H3 mast cells...
November 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29110542/allergen-immunotherapy-in-atopic-dermatitis
#7
Erminia Ridolo, Irene Martignago, Gian Galeazzo Riario-Sforza, Cristoforo Incorvaia
Atopic dermatitis (AD) is a chronic relapsing skin disease, characterized by flare-up due to the exposure to allergens in patients sensitized to them. Currently, therapy of AD is mainly based on symptomatic treatment and avoidance of irritating/allergenic factors, house dust mites being particularly important. Allergen immunotherapy (AIT) is suggested to be the only etiologic treatment, to modify the natural history of the disease. Areas covered: The aim of this review is investigating the putative role of AIT in AD through the evaluation of the most recent scientific literature...
January 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29096848/immunoadsorption-for-treatment-of-severe-atopic-dermatitis
#8
Joanna Wegner, Julia Weinmann-Menke, Esther von Stebut
Atopic dermatitis (AD) is a common disease affecting up to 10-20% of the population with the largest disease burden in childhood. Treatment options include basic emollient treatment, topical as well as systemic immunosuppressants. The pathogenesis is complex and among various triggers, genetic predisposition and immunological alterations contribute to development of disease. Atopy is common in patients with AD and many patients have high levels of Immunoglobulin E (IgE), some of which recognizes exogenous or auto/self-allergens...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29079219/house-dust-mite-allergy-its-innate-immune-response-and-immunotherapy
#9
REVIEW
Fang-Liang Huang, En-Chih Liao, Sheng-Jie Yu
Over the past few decades, allergic diseases have become increasingly prevalent worldwide. House dust mite (HDM) is the most important domestic source for allergic diseases such as allergic rhinitis, asthma and atopic dermatitis. Dermatophagoides pteronyssinus (Der p) is the major environmental allergen in southeast Asia because of the humid and warm environment is suitable for its growth. In the recent year, role of HDM allergen in allergic inflammation through innate immune system has been well studied. Toll-like receptors (TLRs), protease-activated receptors (PARs) and DC-SIGN could be activated by different HDM major allergens and proinflammatory cytokines also be upregulated...
October 16, 2017: Immunobiology
https://www.readbyqxmd.com/read/29062855/house-dust-mite-prevalence-in-the-house-of-patients-with-atopic-dermatitis-in-mashhad-iran
#10
Toktam Ziyaei, Fariba Berenji, Farahzad Jabbari-Azad, Abdolmajid Fata, Lida Jarahi, Mohammad Fereidouni
BACKGROUND: Being exposed to house dust mites intensifies atopic dermatitis. This study has investigated the contamination rate with Dermatophagoides mites in patient's residential home with atopic dermatitis. METHODS: In this cross-sectional study, 40 patients took part with atopic dermatitis (positive or negative for mites by prick Dermal Test). Samples were collected from 3 locations (living room, bedroom and bed) by vacuum cleaner. Dust samples (transferred to freezer -20 °C) were examined by direct method and flotation...
June 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29050978/chrysin-attenuates-atopic-dermatitis-by-suppressing-inflammation-of-keratinocytes
#11
Jin Kyeong Choi, Yong Hyun Jang, Soyoung Lee, Sang-Rae Lee, Young-Ae Choi, Meiling Jin, Jung Ho Choi, Jee Hun Park, Pil-Hoon Park, Hyukjae Choi, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
We previously reported the inhibitory effect of chrysin, a natural flavonoid plentifully contained in propolis, vegetables and fruits, on the mast cell-mediated allergic reaction. In this study, we evaluated the effect of chrysin on atopic dermatitis (AD) and defined underlying mechanisms of action. We used an AD model in BALB/c mice by the repeated local exposure of 2,4-dinitrochlorobenzene (DNCB) and house dust mite (Dermatophagoides farinae extract, DFE) to the ears. Repeated alternative treatment of DNCB/DFE caused AD-like skin lesions...
October 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29047167/the-association-between-an-genetic-risk-score-for-allergy-and-the-risk-of-developing-allergies-in-childhood-results-of-the-whistler-cohort
#12
Ali Arabkhazaeli, Fariba Ahmadizar, Maarten Leusink, Hubertus G M Arets, Jan A M Raaijmakers, Cuno S Uiterwaal, Cornelis K van der Ent, Anke-Hilse Maitland-van der Zee, Susanne J H Vijverberg
BACKGROUND: Several genetic variants have been associated with the susceptibility to allergic disease in adults, but it remains unclear whether these genetic variants are also associated with the onset of allergic disease early in life. The aim of this study was to develop a genetic risk score (GRS) for allergy based on findings in adults and study its predictive capacity for allergy in children. METHODS: A GRS was constructed based on 10 SNPs previously associated with allergies in adults...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29028288/hypochlorous-acid-is-anti-pruritic-and-anti-inflammatory-in-a-mouse-model-of-atopic-dermatitis
#13
Tomoki Fukuyama, Britta C Martel, Keith Linder, Sarah Ehling, Joy Rachel Ganchingco, Wolfgang Bäumer
BACKGROUND: It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of itch in human patients with atopic dermatitis, however the specific anti-pruritic mechanism of action remains unclear. OBJECTIVE: To confirm itch relief and reduction of lesions in a mouse model of atopic dermatitis and to elucidate possible HOCl's mode of action. METHODS: In this study, the effects of topical administration of HOCl hydrogel (0...
October 13, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29022537/respiratory-comorbidity-in-south-african-children-with-atopic-dermatitis
#14
C L Gray, M E Levin, G Du Toit
BACKGROUND: Atopic dermatitis (AD) is an early and important step in the propagation of the allergic march, enhancing food and respiratory allergies via epicutaneous sensitisation to allergens. OBJECTIVES: To determine the prevalence and patterns of aeroallergen sensitisation, asthma and allergic rhinitis in South African (SA) children with AD. METHODS: This was a prospective, observational study in a paediatric university hospital in Cape Town, SA...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28983982/investigation-of-the-correlation-of-serum-il-31-with-severity-of-dermatitis-in-an-experimental-model-of-canine-atopic-dermatitis-using-beagle-dogs
#15
Rosanna Marsella, Kim Ahrens, Rachel Sanford
BACKGROUND: IL-31 is a cytokine that is believed to play an important role in atopic dermatitis (AD). IL-31 levels positively correlate with disease severity in children with AD. Currently, there is no study that has investigated such a correlation in atopic dogs. HYPOTHESIS/OBJECTIVE: The purpose of this study was to evaluate the correlation between IL-31 serum levels and severity of dermatitis. It was hypothesized that a positive correlation exists between severity of AD and circulating levels of IL-31...
October 6, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28977706/dust-mite-induces-multiple-polar-t-cell-axes-in-human-skin
#16
Kunal Malik, Benjamin Ungar, Sandra Garcet, Riana Dutt, Daniel Dickstein, Xiuzhong Zheng, Hui Xu, Yeriel D Estrada, Mayte Suárez-Fariñas, Avner Shemer, James G Krueger, Emma Guttman-Yassky
BACKGROUND: House dust mite/HDM atopy patch test/APT elicits positive reactions in a high fraction of atopic dermatitis/AD and healthy individuals. Experimental systems for new-onset/chronic AD are needed to support rapid therapeutic development, particularly since animal models representing human AD are lacking. While HDM APT has been considered to simulate AD, its suitability to model AD's emerging Th2/Th22 phenotype with Th1 and Th17 components is unknown. OBJECTIVE: To assess whether HDM APT reproduces AD...
October 4, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28887844/house-dust-mite-allergens-der-f-and-der-p-induce-il-31-production-by-blood-derived-t-cells-from-atopic-dermatitis-patients
#17
Krisztina Szegedi, Amanda van Lier, Pieter C Res, Saskia Chielie, Jan D Bos, Sanja Kezic, Maritza A Middelkamp-Hup, Rosalie M Luiten
No abstract text is available yet for this article.
September 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28884988/assessment-of-allergen-specific-ige-by-immunoblotting-method-in-atopic-dermatitis
#18
M R Bonyadi, D Hassanzadeh, N Seyfizadeh, S Borzoueisileh
Background and Objectives. Stimulating the immune system by exposure to various allergens to produce specific IgE has a significant role in the pathogenesis of atopic dermatitis. Identifying disease-causing allergens, prevention of exposure to those allergens, and immunotherapy will play an important role in the treatment of Atopic Disease. The purpose of this study was to determine the common allergens of northwest of Iran in patients with atopic dermatitis that are resistant to treatment. Materials and methods...
September 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28846886/immunomodulatory-effects-induced-by-intramuscular-administration-of-autologous-total-immunoglobulin-g-in-patients-with-atopic-dermatitis
#19
Su-Mi Cho, Myoung-Eun Kim, Byul Kwon, Dong-Ho Nahm
BACKGROUND: Polyvalent human immunoglobulin G (IgG) preparations produced from the plasma pools of healthy blood donors have been used for the treatment of various autoimmune diseases and allergic diseases because of their anti-inflammatory and immunomodulatory effects. We hypothesized that intramuscular administration of autologous total IgG would induce immunomodulatory effects in patients with allergic diseases, based on the clinical efficacy of autologous blood therapy in patients with atopic dermatitis (AD)...
November 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28776792/a-pilot-study-of-the-effect-of-pullulan-conjugated-der-f-2-allergen-specific-immunotherapy-on-canine-atopic-dermatitis
#20
Kouji Kawano, Takuya Mizuno
BACKGROUND: Dermatophagoides farinae is a major and common environmental house dust mite involved in canine atopic dermatitis (CAD). A formulation of recombinant protein Der f 2 is available in Japan for immunotherapy in dogs. HYPOTHESIS/OBJECTIVES: To evaluate the efficacy of a recombinant allergen based on Der f 2-pullulan for the treatment of cAD. METHODS: Dogs (n = 15) with atopic dermatitis were administered Der f 2 conjugated with pullulan (-P)...
August 4, 2017: Veterinary Dermatology
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