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house dust mite dermatitis

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https://www.readbyqxmd.com/read/29679487/allergen-specific-immunotherapy-induces-regulatory-t-cells-in-an-atopic-dermatitis-mouse-model
#1
Jung U Shin, Seo Hyeong Kim, Ji Yeon Noh, Ji Hye Kim, Kim Hye Ran, Kyoung Yong Jeong, Kyung Hee Park, Jungsoo Lee, Howard Chu, Jae-Hyun Lee, Tai-Soon Yong, Jung-Won Park, Kwang Hoon Lee
BACKGROUND: Several studies have demonstrated that allergen-specific immunotherapy (SIT) can be an effective treatment for atopic dermatitis (AD). However, there is no relevant mouse model to investigate the mechanism and validate the novel modality of SIT in AD. METHODS: NC/Nga mice with induced AD-like skin lesions received a subcutaneous injection of SIT (an extract of the house dust mite Dermatophagoides farinae [DfE]) or placebo for 5 weeks). Clinical and histological improvements of AD-like skin lesions were examined...
April 21, 2018: Allergy
https://www.readbyqxmd.com/read/29676071/differences-in-genetic-variations-between-treatable-and-recalcitrant-atopic-dermatitis-in-korean
#2
Myungsoo Jun, Hye Young Wang, Solam Lee, Eunhee Choi, Hyeyoung Lee, Eung Ho Choi
PURPOSE: Variations in barrier- or immune response-related genes are closely related to the development of atopic dermatitis (AD). This study was designed to identify genetic variations and clinical features to predict 'recalcitrant AD.' METHODS: AD patients were classified as treatable and recalcitrant. Treatable AD patients showed satisfactory clinical improvement with basic and topical treatments. Recalcitrant AD patients used systemic immune-suppressants for over 4 weeks as they had not shown clinical improvement with basic and topical treatments...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29656211/esculetin-from-fraxinus-rhynchophylla-attenuates-atopic-skin-inflammation-by-inhibiting-the-expression-of-inflammatory-cytokines
#3
Na-Hee Jeong, Eun-Ju Yang, Meiling Jin, Jong Yeong Lee, Young-Ae Choi, Pil-Hoon Park, Sang-Rae Lee, Sun-Uk Kim, Tae-Yong Shin, Taeg Kyu Kwon, Yong Hyun Jang, Kyung-Sik Song, Sang-Hyun Kim
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder afflicting from infancy to adults with itching, scratching, and lichenification. We aimed to investigate the effects of esculetin from Fraxinus rhynchophylla on atopic skin inflammation. For induction of atopic skin inflammation, we exposed the ears of female BALB/c mice to house dust mite (Dermatophagoides farinae extract, DFE) and 2,4-dinitrochlorobenzene (DNCB) for 4 weeks. Oral administration of esculetin reduced the symptoms of DFE/DNCB-induced atopic skin inflammation, which were evaluated based on ear swelling and number of scratch bouts...
April 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29614845/bee-venom-phospholipase-a2-alleviate-house-dust-mite-induced-atopic-dermatitis-like-skin-lesions-by-the-cd206-mannose-receptor
#4
Dasom Shin, Won Choi, Hyunsu Bae
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house dust mite extract ( Dermatophagoides farinae extract, DFE) in a murine model. However, the underlying mechanisms of PLA2 action in actopic dermatitis remain unclear. In this study, we showed that PLA2 treatment inhibited epidermal thickness, serum immunoglobulin E (IgE) and cytokine levels, macrophage and mast cell infiltration in the ear of an AD model induced by DFE and DNCB...
April 2, 2018: Toxins
https://www.readbyqxmd.com/read/29485689/effect-of-atopic-skin-stressors-on-natural-moisturizing-factors-and-cytokines-in-healthy-adult-epidermis
#5
K A Engebretsen, S Kezic, I Jakasa, A Hedengran, A Linneberg, L Skov, J D Johansen, J P Thyssen
BACKGROUND: Epidermal deficiency of filaggrin, and the derived natural moisturizing factors (NMF), is associated with increased risk of atopic dermatitis (AD). While filaggrin gene mutations cause filaggrin deficiency, there is limited insight in causative environmental factors. OBJECTIVE: To explore the effect of selected exogenous skin stressors on NMF and skin cytokines levels in healthy adult epidermis. MATERIAL AND METHODS: 40 healthy volunteers (18-49 years) were exposed to hard, soft, and chlorinated water, 0...
February 27, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29475513/single-blinded-randomized-placebo-controlled-study-on-the-effects-of-ciclosporin-on-cutaneous-barrier-function-and-immunological-response-in-atopic-beagles
#6
Amelia G White, Domenico Santoro, Kim Ahrens, Rosanna Marsella
Ciclosporin (CsA) is a common treatment for canine atopic dermatitis (cAD). cAD is a very common skin disease with a multifactorial pathogenesis due to complex interactions between the host and the environment. The purpose of this study was to describe the physical and immunological effects of CsA in cAD using a canine model of AD. Fourteen beagles were enrolled; seven received CsA orally every 24 h for 28 days, and seven received placebo. All dogs were exposed to relevant allergens, house dust mite solution, one day prior to treatment and once weekly thereafter for 28 consecutive days...
March 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29427643/new-mechanism-underlying-il-31-induced-atopic-dermatitis
#7
Jianghui Meng, Masaki Moriyama, Micha Feld, Joerg Buddenkotte, Timo Buhl, Attila Szöllösi, Jingming Zhang, Paul Miller, Andre Ghetti, Michael Fischer, Peter W Reeh, Chunxu Shan, Jiafu Wang, Martin Steinhoff
BACKGROUND: T helper type 2 cell-released interleukin 31 (IL-31) is a critical mediator in atopic dermatitis (AD), a prevalent and debilitating chronic skin disorder. Brain-derived natriuretic peptide (BNP) has been described as a central itch mediator. The importance of BNP in peripheral (skin-derived) itch and its functional link to IL-31 within the neuro-immune axis of the skin is unknown. OBJECTIVE: To investigate the function of BNP in the peripheral sensory system and skin in IL-31-induced itch and neuro-epidermal communication in AD...
February 7, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29339444/light-hvem-signaling-in-keratinocytes-controls-development-of-dermatitis
#8
Rana Herro, Jr-Wen Shui, Sonja Zahner, Daniel Sidler, Yuko Kawakami, Toshiaki Kawakami, Koji Tamada, Mitchell Kronenberg, Michael Croft
Dermatitis is often associated with an allergic reaction characterized by excessive type 2 responses leading to epidermal acanthosis, hyperkeratosis, and dermal inflammation. Although factors like IL-4, IL-13, and thymic stromal lymphopoietin (TSLP) are thought to be instrumental for the development of this type of skin disorder, other cytokines may be critical. Here, we show that the tumor necrosis factor (TNF) superfamily protein LIGHT (homologous to lymphotoxin, exhibits inducible expression, and competes with HSV glycoprotein D for binding to HVEM, a receptor expressed on T lymphocytes) is required for experimental atopic dermatitis, and LIGHT directly controls keratinocyte hyperplasia, and production of periostin, a matricellular protein that contributes to the clinical features of atopic dermatitis as well as other skin diseases such as scleroderma...
February 5, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29288652/co-activation-of-glucocorticoid-receptor-and-peroxisome-proliferator-activated-receptor-%C3%AE-in-murine-skin-prevents-worsening-of-atopic-march
#9
Julie Deckers, Nadia Bougarne, Viacheslav Mylka, Sofie Desmet, Astrid Luypaert, Michael Devos, Giel Tanghe, Justine Van Moorleghem, Manon Vanheerswynghels, Lode De Cauwer, Jonathan Thommis, Marnik Vuylsteke, Jan Tavernier, Bart N Lambrecht, Hamida Hammad, Karolien De Bosscher
Children with atopic dermatitis show an increased risk to develop asthma later in life, a phenomenon referred to as "atopic march," which emphasizes the need for secondary prevention therapies. This study aimed to investigate whether relief of skin inflammation by glucocorticoids and peroxisome proliferator-activated receptor agonists might influence the subsequent development of asthma in a murine model for the atopic march in which mice were repeatedly exposed to house dust mite via the skin, followed by exposure to house dust mite in lungs...
December 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29244180/seasonal-variation-of-allergenic-acarofauna-from-the-homes-of-allergic-rhinitis-and-asthmatic-patients
#10
Navpreet Kaur Gill, Amandeep Kaur Dhaliwal
House dust mites (HDMs) play positive role in causing various kinds of allergenic manifestations such as allergic rhinitis (AR), asthma, dermatitis, and urticaria. HDMs are prevalent in temperate regions but various studies have shown the prevalence of HDMs in tropical and subtropical countries. The present study was conducted from March 2015 to February 2016. During the study period, a total of 500 dust samples were collected from 125 homes of 125 patients suffering from AR and asthma. From these 500 dust samples, 466 samples were found to be positive for mites...
February 28, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29209493/comparison-of-atopy-patch-testing-to-skin-prick-testing-for-diagnosing-mite-induced-atopic-dermatitis-a-systematic-review-and-meta-analysis
#11
REVIEW
Yumei Liu, Jianglong Peng, Ying Zhou, Yubao Cui
Background: Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an important tool in the diagnosis of AD caused by house dust mites. Here, we present a meta-analysis comparing APT to the common skin prick test (SPT) in the diagnosis of mite-induced AD. Methods: A structured search was performed using online databases and bibliographies published as of April 30, 2017...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29158156/anti-allergic-effects-of-sesquiterpene-lactones-from-saussurea-costus-falc-lipsch-determined-using-in-vivo-and-in-vitro-experiments
#12
Bo-Kyung Lee, Soo-Jin Park, So-Yeon Nam, Saeromi Kang, Jin Hwang, Seung-Jin Lee, Dong-Soon Im
ETHNOPHARMACOLOGICAL RELEVANCE: Saussurea costus (Falc.) Lipsch. root has been used in Asian traditional medicine for the treatment of asthma, rheumatism, and other conditions. S. costus extracts were shown to alleviate house dust mite-induced atopic-like dermatitis in Nc/Nga mice; besides, sesquiterpene lactones were isolated from S. costus extracts. AIMS OF THE STUDY: We aimed to investigate the effects of sesquiterpene lactones (alantolactone, costunolide, and dehydrocostuslactone) in allergic asthma using female Balb/c mice and rat RBL-2H3 mast cells...
March 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29110542/allergen-immunotherapy-in-atopic-dermatitis
#13
Erminia Ridolo, Irene Martignago, Gian Galeazzo Riario-Sforza, Cristoforo Incorvaia
Atopic dermatitis (AD) is a chronic relapsing skin disease, characterized by flare-up due to the exposure to allergens in patients sensitized to them. Currently, therapy of AD is mainly based on symptomatic treatment and avoidance of irritating/allergenic factors, house dust mites being particularly important. Allergen immunotherapy (AIT) is suggested to be the only etiologic treatment, to modify the natural history of the disease. Areas covered: The aim of this review is investigating the putative role of AIT in AD through the evaluation of the most recent scientific literature...
January 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29096848/immunoadsorption-for-treatment-of-severe-atopic-dermatitis
#14
Joanna Wegner, Julia Weinmann-Menke, Esther von Stebut
Atopic dermatitis (AD) is a common disease affecting up to 10-20% of the population with the largest disease burden in childhood. Treatment options include basic emollient treatment, topical as well as systemic immunosuppressants. The pathogenesis is complex and among various triggers, genetic predisposition and immunological alterations contribute to development of disease. Atopy is common in patients with AD and many patients have high levels of Immunoglobulin E (IgE), some of which recognizes exogenous or auto/self-allergens...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29079219/house-dust-mite-allergy-its-innate-immune-response-and-immunotherapy
#15
REVIEW
Fang-Liang Huang, En-Chih Liao, Sheng-Jie Yu
Over the past few decades, allergic diseases have become increasingly prevalent worldwide. House dust mite (HDM) is the most important domestic source for allergic diseases such as allergic rhinitis, asthma and atopic dermatitis. Dermatophagoides pteronyssinus (Der p) is the major environmental allergen in southeast Asia because of the humid and warm environment is suitable for its growth. In the recent year, role of HDM allergen in allergic inflammation through innate immune system has been well studied. Toll-like receptors (TLRs), protease-activated receptors (PARs) and DC-SIGN could be activated by different HDM major allergens and proinflammatory cytokines also be upregulated...
October 16, 2017: Immunobiology
https://www.readbyqxmd.com/read/29062855/house-dust-mite-prevalence-in-the-house-of-patients-with-atopic-dermatitis-in-mashhad-iran
#16
Toktam Ziyaei, Fariba Berenji, Farahzad Jabbari-Azad, Abdolmajid Fata, Lida Jarahi, Mohammad Fereidouni
BACKGROUND: Being exposed to house dust mites intensifies atopic dermatitis. This study has investigated the contamination rate with Dermatophagoides mites in patient's residential home with atopic dermatitis. METHODS: In this cross-sectional study, 40 patients took part with atopic dermatitis (positive or negative for mites by prick Dermal Test). Samples were collected from 3 locations (living room, bedroom and bed) by vacuum cleaner. Dust samples (transferred to freezer -20 °C) were examined by direct method and flotation...
June 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29050978/chrysin-attenuates-atopic-dermatitis-by-suppressing-inflammation-of-keratinocytes
#17
Jin Kyeong Choi, Yong Hyun Jang, Soyoung Lee, Sang-Rae Lee, Young-Ae Choi, Meiling Jin, Jung Ho Choi, Jee Hun Park, Pil-Hoon Park, Hyukjae Choi, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
We previously reported the inhibitory effect of chrysin, a natural flavonoid plentifully contained in propolis, vegetables and fruits, on the mast cell-mediated allergic reaction. In this study, we evaluated the effect of chrysin on atopic dermatitis (AD) and defined underlying mechanisms of action. We used an AD model in BALB/c mice by the repeated local exposure of 2,4-dinitrochlorobenzene (DNCB) and house dust mite (Dermatophagoides farinae extract, DFE) to the ears. Repeated alternative treatment of DNCB/DFE caused AD-like skin lesions...
October 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29047167/the-association-between-an-genetic-risk-score-for-allergy-and-the-risk-of-developing-allergies-in-childhood-results-of-the-whistler-cohort
#18
Ali Arabkhazaeli, Fariba Ahmadizar, Maarten Leusink, Hubertus G M Arets, Jan A M Raaijmakers, Cuno S Uiterwaal, Cornelis K van der Ent, Anke-Hilse Maitland-van der Zee, Susanne J H Vijverberg
BACKGROUND: Several genetic variants have been associated with the susceptibility to allergic disease in adults, but it remains unclear whether these genetic variants are also associated with the onset of allergic disease early in life. The aim of this study was to develop a genetic risk score (GRS) for allergy based on findings in adults and study its predictive capacity for allergy in children. METHODS: A GRS was constructed based on 10 SNPs previously associated with allergies in adults...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29028288/hypochlorous-acid-is-antipruritic-and-anti-inflammatory-in-a-mouse-model-of-atopic-dermatitis
#19
T Fukuyama, B C Martel, K E Linder, S Ehling, J R Ganchingco, W Bäumer
BACKGROUND: It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of itch in human patients with atopic dermatitis; however, the specific antipruritic mechanism of action remains unclear. OBJECTIVE: To confirm itch relief and reduction of lesions in a mouse model of atopic dermatitis and to elucidate possible HOCl's mode of action. METHODS: In this study, the effects of topical administration of HOCl hydrogel (0...
January 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29022537/respiratory-comorbidity-in-south-african-children-with-atopic-dermatitis
#20
C L Gray, M E Levin, G Du Toit
BACKGROUND: Atopic dermatitis (AD) is an early and important step in the propagation of the allergic march, enhancing food and respiratory allergies via epicutaneous sensitisation to allergens. OBJECTIVES: To determine the prevalence and patterns of aeroallergen sensitisation, asthma and allergic rhinitis in South African (SA) children with AD. METHODS: This was a prospective, observational study in a paediatric university hospital in Cape Town, SA...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
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