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https://www.readbyqxmd.com/read/28070608/xuebijing-injection-treatment-inhibits-vasopermeability-and-reduces-fluid-requirements-in-a-canine-burn-model
#1
F-B Tang, Y-L Dai, S Hu, L-Q Ma, J-Y Li, H-P Zhang, W-H Zhang, Y-G Li, H-B Wang, H-Y Lin, Q Hu, L Li
OBJECTIVE: High vasopermeability and excessive inflammation following severe burns may result in tissue edema, organ dysfunction and the loss of circulatory plasma volume, which can influence the doctor to do the prognosis to the patients. The study aims to examine whether Xuebijing injection (XBJ), an extracts of a traditional Chinese medicine used to treat sepsis in clinic, can reduces fluid requirements by inhibiting vasopermeability and tissue edema in a canine model after burn injury...
January 9, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28057354/neuroendrocrine-tumors-of-the-uterine-cervix-a-therapeutic-challenge-for-gynecologic-oncologists
#2
REVIEW
Gadducci Angiolo, Carinelli Silvestro, Aletti Giovanni
Neuroendocrine tumors (NETs) are aggressive diseases developing from neuroendocrine cells that most frequently involve the gastro-entero-pancreatic tract and the lung, but more rarely are found in almost all body tissues. Limited biological and clinical data are currently available for NETs in uncommon sites, such as female genital tract. NETs represent 0.9% to 1.5% of the tumors of the uterine cervix. They are more likely to have lymph-vascular space invasion and lymph node involvement, and to develop local and distant relapses when compared with the mostly common cervical squamous cell carcinomas or adenocarcinomas...
January 2, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28054150/ki-67-labeling-index-of-neuroendocrine-tumors-of-the-lung-has-a-high-level-of-correspondence-between-biopsy-samples-and-surgical-specimens-when-strict-counting-guidelines-are-applied
#3
Alessandra Fabbri, Mara Cossa, Angelica Sonzogni, Mauro Papotti, Luisella Righi, Gaia Gatti, Patrick Maisonneuve, Barbara Valeri, Ugo Pastorino, Giuseppe Pelosi
Optimal histopathological analysis of biopsies from metastases of neuroendocrine tumor (NET) of the lung requires more than morphology only. Additional parameters such as Ki-67 labeling index are required for adequate diagnosis, but few studies have compared reproducibility of different counting protocols and modalities of reporting on biopsies of lung NET. We compared the results of four different manual counting techniques to establish Ki-67 LI. On 47 paired biopsies and surgical specimens from 22 typical carcinoids (TCs), 14 atypical carcinoids (ACs), six large cell neuroendocrine carcinomas (LCNECs), and five small cell carcinomas (SCCs) immunohistochemical staining of Ki-67 antigen was performed...
January 4, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28047087/su-f-sps-01-accuracy-of-the-small-field-dosimetry-using-acuros-xb-and-aaa-dose-calculation-algorithms-of-eclipse-treatment-planning-system-within-and-beyond-heterogeneous-media-for-trubeam-2-0-unit
#4
G Codel, E Serin, P Pacaci, E Sanli, M Cebe, H Mabhouti, M Doyuran, E Kucukmorkoc, N Kucuk, A Altinok, D Canoglu, H Acar, H Caglar Ozkok
PURPOSE: In this study, the comparison of dosimetric accuracy of Acuros XB and AAA algorithms were investigated for small radiation fields incident on homogeneous and heterogeneous geometries METHODS: Small open fields of Truebeam 2.0 unit (1×1, 2×2, 3×3, 4×4 fields) were used for this study. The fields were incident on homogeneous phantom and in house phantom containing lung, air, and bone inhomogeneities. Using the same film batch, the net OD to dose calibration curve was obtaine dusing Trubeam 2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046425/su-f-sps-02-accuracy-of-the-small-field-dosimetry-using-the-monte-carlo-and-sequential-dose-calculation-algorithms-of-multiplan-treatment-planning-system-within-and-beyond-heterogeneous-media-for-cyberknife-m6-unit
#5
E Serin, G Codel, H Mabhouti, M Cebe, E Sanli, P Pacaci, N Kucuk, E Kucukmorkoc, M Doyuran, D Canoglu, A Altinok, H Acar, H Caglar Ozkok
PURPOSE: In small field geometries, the electronic equilibrium can be lost, making it challenging for the dose-calculation algorithm to accurately predict the dose, especially in the presence of tissue heterogeneities. In this study, dosimetric accuracy of Monte Carlo (MC) advanced dose calculation and sequential algorithms of Multiplan treatment planning system were investigated for small radiation fields incident on homogeneous and heterogeneous geometries. METHODS: Small open fields of fixed cones of Cyberknife M6 unit 100 to 500 mm2 were used for this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042953/cervical-small-cell-neuroendocrine-tumor-mutation-profiles-via-whole-exome-sequencing
#6
Soo Young Cho, Minhye Choi, Hyo-Jeong Ban, Chang Hyeon Lee, Soojun Park, HanKyeom Kim, Young-Sik Kim, Young Seek Lee, Ji-Yun Lee
Cervical small cell neuroendocrine tumors (CSCNETs) are rare, aggressive neuroendocrine tumors (NETs). Reliable diagnostic and prognostic CSCNET markers are lacking, making diagnosis and prognosis prediction difficult, and treatment strategies limited. Here we provide mutation profiles for five tumor-normal paired CSCNETs using whole exome sequencing (WES). We expanded our assessment of frequently mutated genes to include publicly available data from 55 small intestine neuroendocrine tumors, 10 pancreatic neuroendocrine tumors, 42 small cell lung cancers, six NET cell lines, and 188 cervical cancers, along with our five CSCNETs...
December 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/28031479/peptidylarginine-deiminase-4-promotes-age-related-organ-fibrosis
#7
Kimberly Martinod, Thilo Witsch, Luise Erpenbeck, Alexander Savchenko, Hideki Hayashi, Deya Cherpokova, Maureen Gallant, Maximilian Mauler, Stephen M Cifuni, Denisa D Wagner
Aging promotes inflammation, a process contributing to fibrosis and decline in organ function. The release of neutrophil extracellular traps (NETs [NETosis]), orchestrated by peptidylarginine deiminase 4 (PAD4), damages organs in acute inflammatory models. We determined that NETosis is more prevalent in aged mice and investigated the role of PAD4/NETs in age-related organ fibrosis. Reduction in fibrosis was seen in the hearts and lungs of aged PAD4(-/-) mice compared with wild-type (WT) mice. An increase in left ventricular interstitial collagen deposition and a decline in systolic and diastolic function were present only in WT mice, and not in PAD4(-/-) mice...
December 28, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28030917/application-of-the-bpcq-questionnaire-to-assess-pain-management-in-selected-types-of-cancer
#8
Aleksandra Czerw, Urszula Religioni, Andrzej Deptała, Adam Fronczak
INTRODUCTION: Pain is one of the most prevalent unpleasant sensation in people that may significantly lower the quality of life. More than a half of cancer patients suffer from various forms of pain, which becomes more frequent and intense as disease progresses. OBJECTIVE: The objective of the study was to assess the degree of pain control in patients diagnosed with breast, lung, colorectal and prostate cancer. The analysis also covered the effect of socio-economic factors on pain management in patients with the above types of cancer...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28027519/estimation-of-net-survival-for-cancer-patients-relative-survival-setting-more-robust-to-some-assumption-violations-than-cause-specific-setting-a-sensitivity-analysis-on-empirical-data
#9
Robin Schaffar, Bernard Rachet, Aurélien Belot, Laura M Woods
Net survival is the survival that would be observed if the only possible underlying cause of death was the disease under study. It can be estimated with either cause-specific or relative survival data settings, if the informative censoring is properly considered. However, net survival estimators are prone to specific biases related to the data setting itself. We examined which data setting was the most robust against violation of key assumptions (erroneous cause of death and inappropriate life tables). We identified 4285 women in the Geneva Cancer Registry, diagnosed with breast, colorectal, lung cancer and melanoma between 1981 and 1991 and estimated net survival up to 20 years using cause-specific and relative survival settings...
December 24, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28026127/well-differentiated-bronchial-neuroendocrine-tumours-clinical-management-and-outcomes-in-105-patients
#10
Marinos Pericleous, Anna Karpathakis, Christos Toumpanakis, Heather Lumgair, Jonathan Reiner, Laura Marelli, Christina Thirlwell, Martyn E Caplin
INTRODUCTION: Bronchial neuroendocrine tumours (NETs) are rare tumours representing approximately 20-30% of all neuroendocrine tumours and 2-3% of all adult lung cancers. Here, we present a large case series of well-differentiated bronchial NETs with the aim of investigating the behaviour of these tumours and long-term outcomes. METHODS: A retrospective review was performed of 105 patients with bronchial NETs managed in a tertiary referral centre in the period between January 1998-January 2012...
December 27, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28005608/trends-in-net-survival-lung-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#11
Andrea Bordoni, Zoé Uhry, Luis Antunes
Survival is a key measure of the effectiveness of a healthcare system. European Latin countries have some similarities in their health systems; it is thus interesting to examine their differences in survival from cancer, here, lung cancer. The aim of the SUDCAN collaborative study was to compare the trends in the 1- and 5-year net survival from lung cancer and the trends in the excess mortality rates between six European Latin countries (Belgium, France, Italy, Portugal, Spain and Switzerland). The data were extracted from the EUROCARE-5 database...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27991677/a-longitudinal-four-dimensional-computed-tomography-and-cone-beam-computed-tomography-dataset-for-image-guided-radiation-therapy-research-in-lung-cancer
#12
Geoffrey D Hugo, Elisabeth Weiss, William C Sleeman, Salim Balik, Paul J Keall, Jun Lu, Jeffrey F Williamson
PURPOSE: To describe in detail a dataset consisting of serial four-dimensional computed tomography (4DCT) and 4D cone beam CT (4DCBCT) images acquired during chemoradiotherapy of 20 locally-advanced, non-small cell lung cancer patients we have collected at our institution and shared publicly with the research community. ACQUISITION AND VALIDATION METHODS: As part of an NCI-sponsored research study 82 4DCT and 507 4DCBCT images were acquired in a population of 20 locally advanced non-small cell lung cancer patients undergoing radiation therapy...
December 19, 2016: Medical Physics
https://www.readbyqxmd.com/read/27989046/valve-replacement-in-patients-with-carcinoid-heart-disease-choosing-the-right-valve-at-the-right-time
#13
Amit Korach, Simona Grozinsky-Glasberg, Joseph Atlan, Abeer Dabah, Karine Atlan, Ehud Rudis, Amir Elami, David J Gross, Michael J Reardon, Oz M Shapira
BACKGROUND: The prosthetic valve of choice in patients with carcinoid valve disease (CVD) remains controversial due to the limited life expectancy of patients with advanced-stage neuroendocrine tumors (NETs) on the one hand, and concerns regarding structural valve deterioration (SVD) on the other hand. METHODS: The records of 17 patients (11 females, seven males; mean age 65 ± 11 years; undergoing 18 operations) with primarily right heart failure due to CVD were reviewed...
May 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27983632/antimicrobial-and-antitumor-activities-of-novel-peptides-derived-from-the-lipopolysaccharide-and-%C3%AE-1-3-glucan-binding-protein-of-the-pacific-abalone-haliotis-discus-hannai
#14
Bo-Hye Nam, Ji Young Moon, Eun Hee Park, Hee Jeong Kong, Young-Ok Kim, Dong-Gyun Kim, Woo-Jin Kim, Chul Min An, Jung-Kil Seo
Antimicrobial peptides are a pivotal component of the invertebrate innate immune system. In this study, we identified a lipopolysaccharide- and β-1,3-glucan-binding protein (LGBP) gene from the pacific abalone Haliotis discus hannai (HDH), which is involved in the pattern recognition mechanism and plays avital role in the defense mechanism of invertebrates immune system. The HDH-LGBP cDNA consisted of a 1263-bp open reading frame (ORF) encoding a polypeptide of 420 amino acids, with a 20-amino-acid signal sequence...
December 14, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27981858/budget-impact-of-everolimus-for-the-treatment-of-progressive-well-differentiated-non-functional-neuroendocrine-tumors-of-gastrointestinal-or-lung-origin-that-are-advanced-or-metastatic
#15
Darya B Rose, Dave Nellesen, Maureen P Neary, Beilei Cai
BACKGROUND: Advanced neuroendocrine tumors (NETs) are a rare malignancy with considerable need for effective therapies. Everolimus is a mammalian target of rapamycin (mTOR) inhibitor approved by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) in 2016 for treatment of adults with progressive, well-differentiated, non-functional NETs of gastrointestinal (GI) or lung origin that are unresectable, locally advanced, or metastatic. OBJECTIVE: To assess the 3-year budget impact for a typical US health plan following availability of everolimus for treatment of GI and lung NETs...
December 16, 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/27969490/ps01-23-epidemiology-of-neuroendocrine-tumors-net-of-the-lung-in-the-us-analysis-of-2-large-insurance-claims-databases-topic-medical-oncology
#16
Beilei Cai, Michael S Broder, Eunice Chang, Caroline Burk, Krzysztof J Grzegorzewski, Maureen P Neary
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27969445/oral02-02-efficacy-and-safety-of-everolimus-in-advanced-progressive-nonfunctional-neuroendocrine-tumors-net-of-the-lung-radiant-4-subgroup-analysis-topic-medical-oncology
#17
James Yao, Nicola Fazio, Roberto Buzzoni, Gianfranco Delle Fave, Margot Tesselaar, Edward Wolin, Eric Van Cutsem, Paola Tomassetti, Jonathan Strosberg, Maurizio Voi, Lida Pacaud, Antonia Ridolfi, Simron Singh, Marianne Pavel, Matthew Kulke
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27959278/modulatory-potential-of-resveratrol-during-lung-inflammatory-disease
#18
José Eduardo Vargas, André Arigony Souto, Paulo Márcio Condessa Pitrez, Renato Tetelbom Stein, Bárbara Nery Porto
Neutrophils are the first cells to achieve the sites of infection or inflammation in the lungs. The massive accumulation of these cells is associated with acute and chronic lung injury. Therefore, they have been implicated in the pathogenesis of many lung diseases through the release of reactive oxygen intermediates, proteolytic enzymes and Neutrophil Extracellular Traps (NETs). The excessive and continuous release of NETs, fibers composed by decondensed chromatin coated with neutrophil proteins, are associated to the impairment of lung function in different pathological settings...
November 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27926944/targeting-neutrophils-to-prevent-malaria-associated-acute-lung-injury-acute-respiratory-distress-syndrome-in-mice
#19
Michelle K Sercundes, Luana S Ortolan, Daniela Debone, Paulo V Soeiro-Pereira, Eliane Gomes, Elizabeth H Aitken, Antonio Condino Neto, Momtchilo Russo, Maria R D' Império Lima, José M Alvarez, Silvia Portugal, Claudio R F Marinho, Sabrina Epiphanio
Malaria remains one of the greatest burdens to global health, causing nearly 500,000 deaths in 2014. When manifesting in the lungs, severe malaria causes acute lung injury/acute respiratory distress syndrome (ALI/ARDS). We have previously shown that a proportion of DBA/2 mice infected with Plasmodium berghei ANKA (PbA) develop ALI/ARDS and that these mice recapitulate various aspects of the human syndrome, such as pulmonary edema, hemorrhaging, pleural effusion and hypoxemia. Herein, we investigated the role of neutrophils in the pathogenesis of malaria-associated ALI/ARDS...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27917008/visualization-of-neutrophil-extracellular-traps-and-fibrin-meshwork-in-human-fibrinopurulent-inflammatory-lesions-iii-correlative-light-and-electron-microscopic-study
#20
Takanori Onouchi, Kazuya Shiogama, Yasuyoshi Mizutani, Takashi Takaki, Yutaka Tsutsumi
Neutrophil extracellular traps (NETs) released from dead neutrophils at the site of inflammation represent webs of neutrophilic DNA stretches dotted with granule-derived antimicrobial proteins, including lactoferrin, and play important roles in innate immunity against microbial infection. We have shown the coexistence of NETs and fibrin meshwork in varied fibrinopurulent inflammatory lesions at both light and electron microscopic levels. In the present study, correlative light and electron microscopy (CLEM) employing confocal laser scanning microscopy and scanning electron microscopy was performed to bridge light and electron microscopic images of NETs and fibrin fibrils in formalin-fixed, paraffin-embedded, autopsied lung sections of legionnaire's pneumonia...
November 1, 2016: Acta Histochemica et Cytochemica
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