Charlotte E Berry, Darren B Abbas, Michelle Griffin, Hendrik Lintel, Jason Guo, Lionel Kameni, Andrew A Churukian, Alexander Z Fazilat, Kellen Chen, Geoffrey C Gurtner, Michael T Longaker, Arash Momeni, Derrick C Wan
Topical patch delivery of deferoxamine (DFO) has been studied as a treatment for this fibrotic transformation in irradiated tissue. Efficacy of a novel cream formulation of DFO was studied as a RIF therapeutic in unwounded and excisionally wounded irradiated skin. C57BL/6J mice underwent 30 Gy of radiation to the dorsum followed by 4 weeks of recovery. In a first experiment, mice were separated into six conditions: DFO 50 mg cream (D50), DFO 100 mg cream (D100), soluble DFO injections (DI), DFO 1 mg patch (DP), control cream (Vehicle), and irradiated untreated skin (IR)...
April 2024: Journal of Cellular and Molecular Medicine