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https://www.readbyqxmd.com/read/29141064/port-wine-stains-a-focused-review-on-their-management
#1
Katelyn Mariko Updyke, Amor Khachemoune
<p>Port-wine stain (PWS) is the second most common congenital vascular malformation characterized as ectatic capillaries and venules in the dermis that clinically appears as a deep red to purple patch on the skin. Typically, PWS progressively darken and may become hypertrophic or nodular without treatment. There are several treatment options available for PWS from topical antiangiogenic agents to laser therapies. Vascular-specific lasers are the gold standard in treating PWS and classically pulsed dye lasers are usually the treatment of choice...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29141060/efficacy-of-low-fluence-nd-yag-1064-nm-laser-for-the-treatment-of-post-inflammatory-hyperpigmentation-in-the-axillary-area
#2
Sahar Ghannam, Fatemah K Al Otabi, Konstantin Frank, Sebastian Cotofana
<p>OBJECTIVE: Post-inflammatory hyperpigmentation results in aesthetically unpleasant discoloration of the skin in the affected area. The efficacy of low-fluence Q-switched 1064-nm Nd:YAG laser has so far not been evaluated for the treatment of the axilla. This observational study was designed to evaluate whether the application of the laser treatment can satisfactorily reduce axillary hyperpigmentation. MATERIAL AND METHODS: 17 females (mean age, 34.27 ± 9.24; range, 19-48) were treated in a single center between 2014 and 2016 for post-inflammatory hyperpigmentation of the axillary area...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29141056/in-vivo-histological-analysis-of-a-fractional-co2-laser-system-intended-for-treatment-of-soft-tissue
#3
Elisabeth Hurliman, Brian Zelickson, Jeffrey Kenkel
<p>BACKGROUND: Fractional ablative lasers have been shown to be safe and effective for improving wrinkles, scars, skin texture, and dyspigmentation. However, the exact effects of this technology in vivo on epidermal and dermal skin constituents have not been delineated. This study evaluated the in vivo histological effects over time of treatment with a fractional ablative CO2 system, using different treatment parameters. MATERIALS AND METHODS: Healthy adult volunteers were enrolled in this multicenter clinical study...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29141054/managing-seborrheic-keratoses-evolving-strategies-for-optimizing-patient-outcomes
#4
Geraldine Cheyana Ranasinghe, Adam J Friedman
<p>The seborrheic keratosis is the most common benign skin tumor of middle-aged and elderly adults, affecting nearly 83 million individuals in the US alone. Although these are benign lesions, many patients still undergo some form of treatment. Clinicians are frequently presented with a challenge when determining whether to remove a seborrheic keratosis, and which treatment modality to use when doing so. The most commonly used method of removal is cryotherapy, however there are numerous other options that can be employed with varying degrees of efficacy...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29141048/microcirculation-in-open-vs-minimally-invasive-dorsal-stabilization-of-thoracolumbar-fractures
#5
Bergita Ganse, Miguel Pishnamaz, Philipp Kobbe, Christian Herren, Gertraud Gradl-Dietsch, Franziska Böhle, Bernd Johannes, Bong-Sung Kim, Klemens Horst, Matthias Knobe
Standard open and percutaneous minimally invasive surgical procedures co-exist in the treatment of fractures of the thoracolumbar spine. Shorter skin incisions just above the pedicles are used in minimally invasive procedures. Full-length skin incisions and invasive preparations are applied in the standard open approach. While both methods show equivalent rates of intraoperative surgical complications and comparable clinical and radiological outcomes, blood loss and operation time have shown to be decreased in minimally invasive treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29140866/one-thousand-five-hundred-fifty-nanometer-erbium-doped-nonablative-fractional-laser-for-the-treatment-of-striae-distensae-in-patients-of-skin-of-color-fitzpatrick-skin-types-iv-vi
#6
Kelly K Park, Erin Roberts, Rebecca C Tung
No abstract text is available yet for this article.
November 14, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29139245/evaluation-of-a-pointwise-microcirculation-assessment-method-using-liquid-and-multilayered-tissue-simulating-phantoms
#7
Ingemar Fredriksson, Rolf B Saager, Anthony J Durkin, Tomas Strömberg
A fiber-optic probe-based instrument, designed for assessment of parameters related to microcirculation, red blood cell tissue fraction (fRBC), oxygen saturation (SO2), and speed resolved perfusion, has been evaluated using state-of-the-art tissue phantoms. The probe integrates diffuse reflectance spectroscopy (DRS) at two source-detector separations and laser Doppler flowmetry, using an inverse Monte Carlo method for identifying the parameters of a multilayered tissue model. Here, we characterize the accuracy of the DRS aspect of the instrument using (1) liquid blood phantoms containing yeast and (2) epidermis-dermis mimicking solid-layered phantoms fabricated from polydimethylsiloxane, titanium oxide, hemoglobin, and coffee...
November 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29138594/prevention-and-treatment-of-acute-and-chronic-radiodermatitis
#8
Sophie Seité, René-Jean Bensadoun, Jean-Michel Mazer
More than half the number of patients with cancer, who are treated with radiotherapy, will have radiodermatitis at some point during their treatment. Radiodermatitis either occurs early on in the treatment period or appears months or up to several years later. Acute radiodermatitis is a burn injury that varies in severity according to both treatment and inherent patient factors. Most acute radiodermatitis reactions resolve after several weeks but some reactions persist and can cause complications. Late-onset radiodermatitis is characterized by telangiectasia that forms on atrophic and fragile skin...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29138062/topical-calcipotriol-prior-to-ablative-fractional-laser-assisted-photodynamic-therapy-enhances-treatment-outcomes-for-actinic-keratosis-in-fitzpatrick-grades-iii-v-skin-a-prospective-randomized-clinical-trial
#9
Jeong-Wan Seo, Ki-Hoon Song
No abstract text is available yet for this article.
November 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29135894/deferoxamine-preconditioning-of-irradiated-tissue-improves-perfusion-and-fat-graft-retention
#10
John Flacco, Natalie Chung, Charles P Blackshear, Dre Irizarry, Arash Momeni, Gordon K Lee, Dung Nguyen, Geoffrey C Gurtner, Michael T Longaker, Derrick C Wan
BACKGROUND: Radiation therapy is a mainstay in the treatment of many malignancies, but collateral damage to surrounding tissue, with resultant hypovascularity, fibrosis, and atrophy, can be difficult to reconstruct. Fat grafting has been shown to improve the quality of irradiated skin, but volume retention of the graft is significantly decreased. Deferoxamine (DFO) is a FDA-approved iron-chelating medication for acute iron intoxication and chronic iron overload that has also been shown to increase angiogenesis...
November 8, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29131633/effect-of-the-helix-coil-transition-in-bovine-skin-gelatin-on-its-associative-phase-separation-with-lysozyme
#11
Yurij A Antonov, Irina Zhuravleva, Alexander Volodine, Paula Moldenaers, Ruth Cardinaels
It is known that the formation of electrostatic polyelectrolyte complexes can induce conformational changes in the interacting macromolecules. However, the opposite effect, namely, that of the helix-coil transition of one of the interacting polyelectrolytes on its associative phase separation with another polyelectrolyte and the possible phase transitions in such systems, has not been determined. Atomic force and confocal laser scanning microscopy, phase analysis, dynamic and electrophoretic light scattering, turbidimetry, absorption, and fluorescence measurements as well as differential scanning calorimetry and rheology were used to study the effect of the helix-coil transition in bovine skin gelatin (Gel) on its associative phase separation with hen egg white lysozyme (Lys) at different temperatures (18-40 °C) and various Lys/Gel weight ratios (0...
November 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29131366/successful-and-safe-use-of-q-switched-lasers-in-the-treatment-of-nevus-of-ota-in-children-with-phototypes-iv-vi
#12
Daniel A Belkin, Hana Jeon, Elliot Weiss, Jeremy A Brauer, Roy G Geronemus
OBJECTIVE: Nevus of Ota represents congenital dermal melanocytosis in a trigeminal distribution, most commonly occurring in Asian individuals and other individuals with skin of color. Evidence suggests early treatment is beneficial. Multiple reports have shown efficacy and safety of Q-switched laser treatment in adults. There is little data on children and in non-Asian skin types. This series was done to demonstrate safe and effective use of Q-switched laser therapy in children of multiple skin types...
November 13, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29130596/evaluation-of-a-bioengineered-construct-for-tissue-engineering-applications
#13
Perla Ayala, Erbin Dai, Michael Hawes, Liying Liu, Ovijit Chaudhuri, Carolyn A Haller, David J Mooney, Elliot L Chaikof
Effective biomaterial options for tissue repair and regeneration are limited. Current biologic meshes are derived from different tissue sources and are generally sold as decellularized tissues. This work evaluated two collagen based bioengineered constructs and a commercial product in a model of abdominal full thickness defect repair. To prepare the bioengineered construct, collagen type 1 from porcine skin was isolated using an acid solubilization method. After purification, the collagen was formed into collagen sheets that were physically bonded to form a mechanically robust construct that was subsequently laser micropatterned with pores as a means to promote tissue integration (collagen only construct)...
November 11, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29125215/additive-manufacturing-a-comparative-analysis-of-dimensional-accuracy-and-skin-texture-reproduction-of-auricular-prostheses-replicas
#14
Alexey Unkovskiy, Sebastian Spintzyk, Detlef Axmann, Eva-Maria Engel, Heiner Weber, Fabian Huettig
PURPOSE: The use of computer-aided design/computer-aided manufacturing (CAD/CAM) and additive manufacturing in maxillofacial prosthetics has been widely acknowledged. Rapid prototyping can be considered for manufacturing of auricular prostheses. Therefore, so-called prostheses replicas can be fabricated by digital means. The objective of this study was to identify a superior additive manufacturing method to fabricate auricular prosthesis replicas (APRs) within a digital workflow. MATERIALS AND METHODS: Auricles of 23 healthy subjects (mean age of 37...
November 10, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29124708/phototherapy-in-atopic-dermatitis
#15
José María Ortiz-Salvador, Amparo Pérez-Ferriols
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases. Currently management of AD includes avoidance of triggering factors, skin care aiming to compensate the skin barrier defects, anti-inflammatory therapy (mostly topical corticosteroids and topical calcineurin inhibitors). When these first-line approaches are unsuccessful, systemic treatment or phototherapy ought to be carried out as next line of defence. Current phototherapy modalities for AD include broadband UVB (290-320 nm), narrowband UVB (311-313 nm), UVA-1 therapy (340-400 nm), UVA therapy plus 8-methoxypsoralens (PUVA), 308 nm excimer laser (EL) and Full spectrum light (FSL)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29122959/prefrontal-oxygenation-correlates-to-the-responses-in-facial-skin-blood-flows-during-exposure-to-pleasantly-charged-movie
#16
Kanji Matsukawa, Kana Endo, Ryota Asahara, Miho Yoshikawa, Shinya Kusunoki, Tomoko Ishida
Our laboratory reported that facial skin blood flow may serve as a sensitive tool to assess an emotional status. Cerebral neural correlates during emotional interventions should be sought in relation to the changes in facial skin blood flow. To test the hypothesis that prefrontal activity has positive relation to the changes in facial skin blood flow during emotionally charged stimulation, we examined the dynamic changes in prefrontal oxygenation (with near-infrared spectroscopy) and facial skin blood flows (with two-dimensional laser speckle and Doppler flowmetry) during emotionally charged audiovisual challenges for 2 min (by viewing comedy, landscape, and horror movie) in 14 subjects...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29120183/thermoresponsive-surface-grafted-gels-controlling-the-bulk-volume-change-properties-by-surface-localized-polymer-grafting-with-various-densities
#17
Ko Matsukawa, Tsukuru Masuda, Youn Soo Kim, Aya Mizutani Akimoto, Ryo Yoshida
We prepared poly(N-isopropylacrylamide-r-N-3-(aminopropyl)methacrylamide) (poly(NIPAAm-r-NAPMAm)) gels with poly NIPAAm (PNIPAAm) grafted only in the surface region (so-called thermoresponsive "surface-grafted gels") with various graft densities, and investigated the effect of the graft density on the bulk properties, such as shrinking and swelling, in response to temperature changes. Initiators for atom transfer radical polymerization (ATRP) and structurally analogous compounds were introduced at certain ratios to the surface regions of the gels, and a subsequent activator regenerated by electron transfer ATRP of NIPAAm was conducted in aqueous media...
November 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29117995/the-role-of-mitochondria-derived-reactive-oxygen-species-in-microvascular-dysfunction-in-chronic-kidney-disease
#18
Danielle L Kirkman, Bryce J Muth, Meghan G Ramick, Raymond R Townsend, David G Edwards
Cardiovascular disease is the leading cause of mortality in Chronic Kidney Disease (CKD). Mitochondrial dysfunction secondary to CKD is a potential source of oxidative stress that may impair vascular function. This study sought to determine if mitochondria derived reactive oxygen species contribute to microvascular dysfunction in Stage 3-5 CKD. Cutaneous vasodilation in response to local heating was assessed in 20 CKD patients (60±13 years; eGFR 46±13ml/kg/1.73m2) and eleven matched healthy participants (58±2 years; eGFR>90ml/kg/1...
November 8, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29116332/-therapy-of-scars-with-lasers
#19
REVIEW
G G Gauglitz, J Pötschke, M T Clementoni
Scar formation is the consequence of trauma to the skin that affects the deep parts of the dermis. Different scar types like immature, mature, atrophic, hypertrophic, or keloid scars can develop depending on factors like age, anatomic localization, cause of trauma, the course of the healing process, and individual predispositions. Keloids and hypertrophic scars are often associated with itching, pain, tautness of the skin, and functional impairments, thus, leading to significantly reduced quality of life in some patients...
November 7, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29112535/tempo-spatial-discrimination-is-lower-for-noxious-stimuli-than-for-innocuous-stimuli
#20
Ken Steffen Frahm, Carsten Dahl Mørch, Ole Kæseler Andersen
The exteroceptive sensory system is responsible for sensing external stimuli in relation to time and space. The aim of this study was to investigate the tempo-spatial properties of the exteroceptive system using painful laser heat and non-painful mechanical touch stimulation.Thirteen healthy subjects were stimulated on the volar forearm using two paradigms: a continuous stimulation along a line on the skin and a 2-point stimulation. The line stimulations were delivered in both the distal and proximal direction with lengths of 25, 50, 75, and 100mm...
October 30, 2017: Pain
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