keyword
https://read.qxmd.com/read/38491736/real-life-data-over-36%C3%A2-weeks-of-guselkumab-treatment-in-psoriasis-patients-a-single-center-study-from-turkey
#1
JOURNAL ARTICLE
Eda Öksüm Solak, Fatih Can Aba, Salih Levent Çınar, Demet Kartal, Murat Borlu
BACKGROUND: Psoriasis is an important health problem responsible for morbidity and workforce loss. In recent years, anti-IL-23 drugs have become essential in psoriasis treatment. OBJECTIVES: This study aimed to investigate the efficacy and safety of guselkumab therapy, recently used in Turkey, by examining real-life data over 36 weeks. METHODS: A total of 39 psoriasis patients (>18 years old) who received guselkumab treatment between December 2021 and December 2022 in the dermatology department of our hospital were included in the study...
March 15, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38489702/effect-of-co2-fractional-laser-combined-with-recombinant-human-epidermal-growth-factor-gel-on-skin-barrier
#2
JOURNAL ARTICLE
Hua Wang, Fan Yang, Hui Wang, Tao Qin, Jia He, Chan Zhao
To evaluate the impact of CO2 fractional laser combined with recombinant human epidermal growth factor (rhEGF) gel on skin barrier in acne scar patients. In a retrospective analysis, we examined 105 acne scar patients admitted between July 2018 and August 2021. Of these, 51 received only CO2 fractional laser (control group), while 54 underwent a combination of CO2 fractional laser and rhEGF gel (observation group). We assessed treatment efficacy, symptom relief, skin barrier parameters, pre- and posttreatment inflammatory factors, adverse reactions, posttreatment quality of life, and patient satisfaction...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38488328/dandruff-lesional-scalp-skin-exhibits-epidermal-t-cell-infiltration-and-a-weakened-hair-follicle-immune-privilege
#3
JOURNAL ARTICLE
Susan L Limbu, Talveen S Purba, Matthew Harries, Rhia Kundu, Ranjit K Bhogal, Ralf Paus
OBJECTIVE: Dandruff is characterised by the presence of perivascular leukocytes and mild inflammation; however, the immune microenvironment of dandruff-affected scalp skin and the potential changes to the hair follicle's (HF) physiological immune privilege (HF IP) remain unknown. Here, we characterised the HF immune microenvironment and immune privilege status in dandruff-affected scalp skin. METHODS: We assessed relevant key parameters in healthy versus dandruff-affected human scalp biopsies using quantitative immunohistomorphometry, laser capture microdissection, and RNA sequencing...
March 15, 2024: International Journal of Cosmetic Science
https://read.qxmd.com/read/38487972/salmonella-driven-intestinal-edema-in-mice-is-characterized-by-tensed-fibronectin-fibers
#4
JOURNAL ARTICLE
Ronja Rappold, Konstantinos Kalogeropoulos, Ulrich Auf dem Keller, Viola Vogel, Emma Slack
Intestinal edema is a common manifestation of numerous gastrointestinal diseases and is characterized by the accumulation of fluid in the interstitial space of the intestinal wall. Technical advances in laser capture microdissection and low-biomass proteomics now allow us to specifically characterize the intestinal edema proteome. Using advanced proteomics, we identify peptides derived from antimicrobial factors with high signal intensity, but also highlight major contributions from the blood clotting system, extracellular matrix (ECM) and protease-protease inhibitor networks...
March 15, 2024: FEBS Journal
https://read.qxmd.com/read/38487954/restoring-long-lasting-midface-volume-in-the-asian-face-with-a-hyaluronic-acid-filler-a-randomized-controlled-multicenter-study
#5
JOURNAL ARTICLE
Rongxin Ren, Hongyu Xue, Zhanwei Gao, Hang Wang, Xiujuan Xia, Yan Qu, Torun Bromée, Birgitta Almegård, Hongyi Zhao
BACKGROUND: Hyaluronic acid (HA) filler treatment is a minimally-invasive alternative to surgery to volumize the cheeks. HAVOL (Restylane® Volyme) is a flexible HA filler suited to contouring and volumizing the midface. METHODS: This randomized, evaluator-blinded, no-treatment controlled study evaluated effectiveness and safety of HAVOL for correction of midface volume deficit and midface contour deficiency in Chinese subjects. In total 111 subjects were randomized to HAVOL and 37 to no treatment (control)...
March 15, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38482522/dissolving-microneedle-based-cascade-activation-nanoplatform-for-enhanced-photodynamic-therapy-of-skin-cancer
#6
JOURNAL ARTICLE
Jinyuan Ma, Zongguang Tai, Ying Li, Yang Li, Jiandong Wang, Tao Zhou, Min Shen, Rujuan Xin, Cuie Shen, Quangang Zhu, Zhongjian Chen
PURPOSE: Photodynamic therapy (PDT) has been an attractive strategy for skin tumor treatment. However, the hypoxic microenvironment of solid tumors and further O2 consumption during PDT would diminish its therapeutic effect. Herein, we developed a strategy using the combination of PDT and hypoxia-activated bioreductive drug tirapazamine (TPZ). METHODS: TPZ was linked to DSPE-PEG-NHS forming DSPE-PEG-TPZ to solve leakage of water-soluble TPZ and serve as an antitumor agent and monomer molecule further forming the micellar...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38481059/successful-treatment-of-cutaneous-protothecosis-with-fluconazole-a-case-report-and-epidemiology-study-of-prototheca-infection-in-china
#7
JOURNAL ARTICLE
Chandi Xu, Chaolan Pan, Chengan Xu, Wei Zheng, Qiaoqiao Yin, Hongying Pan, Yingjun Chen
BACKGROUND: Protothecosis is an infection of humans and animals caused by a rare conditionally pathogenic fungus (prototheca). It can occur in immunocompromised or normal patients. AIMS: To describe the epidemiology of prototheca infection in China. METHODS: We report a case of successful treatment of cutaneous protothecosis with fluconazole and analyzed the epidemiological characteristics, risk factors, clinical manifestations, diagnosis, treatment and prognosis of prototheca infections in China...
March 13, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38481037/the-role-of-the-beautician-in-reducing-striae
#8
REVIEW
Monika Rusztowicz, Karolina Chilicka, Michael H Gold, Renata Szyguła, Sławomir Wilczyński, Barbara Błońska-Fajfrowska
INTRODUCTION: Striae distensae are a permanent skin defect that can affect 50%-90% of the population. The appearance of the changes resembles spindle-shaped skin bands. The skin in this area is wrinkled, thin and looks like a scar. Most often, the changes are found on the skin of the abdomen, buttocks, breasts, thighs, and back. The appearance of striae means that the skin in this area has no hair follicles, sebaceous, and sweat glands. This skin is flabby, not very elastic and, what is very characteristic, the pigmentation of the skin affected by striae is much lower than in healthy skin...
March 13, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38480984/ameliorated-skin-inflammation-through-the-synergistic-effect-of-gold-nanorod-dexamethasone-and-photothermal-therapy
#9
JOURNAL ARTICLE
Namkyung Kim, Yong-Gyu Jeong, Soyoung Lee, Jinjoo Kang, Yeyoung Kim, Young-Ae Choi, Dongwoo Khang, Sang-Hyun Kim
Psoriasis, a prevalent chronic inflammatory skin ailment affecting approximately 2-3% of the global population, is characterized by persistent symptoms. Dexamethasone, a primary corticosteroid for treating psoriasis, demonstrates notable efficacy; however, its limited skin permeation results in documented adverse effects. To address this, the presented study employed a novel strategy to conjugate gold nanorod and dexamethasone and evaluate their potential for mitigating psoriatic inflammation using an imiquimod-induced mouse model and human skin cells...
March 13, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38479485/comparative-evaluation-of-physical-and-chemical-enhancement-techniques-for-transdermal-delivery-of-linagliptin
#10
JOURNAL ARTICLE
Tanvi Karve, Ajay K Banga
Linagliptin is a dipeptidyl peptidase-4 inhibitor used for the management of type-2 diabetes. US FDA-approved products are available exclusively as oral tablets. The inherent drawbacks of the oral administration route necessitate exploring delivery strategies via other routes. In this study, we investigated the feasibility of transdermal administration of linagliptin through various approaches. We compared chemical penetration enhancers (oleic acid, oleyl alcohol, and isopropyl myristate) and physical enhancement techniques (iontophoresis, sonophoresis, microneedles, laser, and microdermabrasion) to understand their potential to improve transdermal delivery of linagliptin...
March 11, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38477881/delayed-onset-type-i-allergic-reaction-following-black-tattoo-removal-using-picosecond-laser
#11
JOURNAL ARTICLE
Suzanne van Santen, Esther J van Zuuren, Albert Wolkerstorfer, Sebastiaan A S van der Bent
No abstract text is available yet for this article.
March 13, 2024: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/38476441/can-acupuncture-increase-microcirculation-in-peripheral-artery-disease-and-diabetic-foot-syndrome-a-pilot-study
#12
JOURNAL ARTICLE
Jan Valentini, Martin Sigl, Cornelia Dunckel, Johannes Krisam, Klaus Amendt, Henry Johannes Greten
BACKGROUND: Globally, diabetes mellitus (DM) and peripheral artery disease (PAD) have an increasing incidence and a high prevalence and are both associated with high morbidity and complication rates, e.g., as chronic non-healing peripheral ulcers. Impaired macro- and microcirculation and peripheral neuropathy lead to an increased risk of foot ulcers and infections. These complications are difficult to treat, have a high risk of becoming chronic and often lead to lower limb amputation...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38476403/terahertz-in-vivo-imaging-of-human-skin-toward-detection-of-abnormal-skin-pathologies
#13
JOURNAL ARTICLE
X Qi, K Bertling, J Torniainen, F Kong, T Gillespie, C Primiero, M S Stark, P Dean, D Indjin, L H Li, E H Linfield, A G Davies, M Brünig, T Mills, C Rosendahl, H P Soyer, A D Rakić
Terahertz (THz) imaging has long held promise for skin cancer detection but has been hampered by the lack of practical technological implementation. In this article, we introduce a technique for discriminating several skin pathologies using a coherent THz confocal system based on a THz quantum cascade laser. High resolution in vivo THz images (with diffraction limited to the order of 100  μ m) of several different lesion types were acquired and compared against one another using the amplitude and phase values...
March 2024: APL Bioengineering
https://read.qxmd.com/read/38475901/eyelash-serums-a-comprehensive-review
#14
REVIEW
Maya Baiyasi, Kayla St Claire, Meredith Hengy, Komal Tur, Fatima Fahs, Geoffrey Potts
BACKGROUND: Eyelash serums, both prescription and over-the-counter, are gaining popularity for enhancing the appearance of eyelashes through various biologically active molecules. Categorized into prostaglandin analogs and non-prostaglandin analogs, these serums claim increased strength, length, luster, and thickness. Current United States law also requires no efficacy or safety assessments by the Food and Drug Administration before approving products for consumer use, potentially posing health risks for patients seeking over-the-counter eyelash enhancements...
March 12, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38470813/new-approaches-to-second-degree-burn-healing-polyvinyl-alcohol-membrane-loaded-to-arnica-combined-to-laser-therapy
#15
JOURNAL ARTICLE
Carolina Silva Cardoso, Filipe Feitosa de Carvalho, Rodrigo César Gomes, Reinaldo José Gianini, Camilla Fanelli, Irene de Lourdes Noronha, Nelson Brancaccio Dos Santos, Daniel Komatsu, Priscila Randazzo-Moura
Second-degree burns require greater care, as the damage is more extensive and worrisome and the use of a biomaterial can help in the cell repair process, with better planning, low cost, and better accessibility. Arnica has anti-inflammatory and analgesic properties in skin lesions treatments and laser therapy is another therapeutic alternative for burns. Evaluate the effects of arnica incorporated into PVA associated or not with low intensity laser on burns in rats. PVA and PVA with arnica (PVA+A) were obtained and characterized physicochemically...
March 12, 2024: Journal of Biomaterials Applications
https://read.qxmd.com/read/38470079/evaluation-of-efficacy-and-safety-of-vitiligo-treatment-with-micro-needling-combined-with-n-acetylcysteine-and-micro-needling-alone-a-double-blinded-randomized-controlled-clinical-trial
#16
JOURNAL ARTICLE
Najmolsadat Atefi, Elham Ziaeifar, Farnoosh Seirafianpour, Afsaneh Sadeghzadeh-Bazargan, Nazila Ghoreishi Amin, Samaneh Mozafarpoor, Abolfazl Abouie, Mohammad Amin Jafari, Azadeh Goodarzi
INTRODUCTION: Vitiligo is a skin pigmentation disorder caused by the selective degradation of melanocytes. This study investigates the therapeutic effects of microneedling with and without N-acetylcysteine (NAC) in patients with persistent and limited vitiligo. METHOD: This research employed a clinical trial design with double-blind randomization. Individuals affected by vitiligo and seeking treatment at Rasool Akram Medical Complex were divided into two separate treatment groups...
March 12, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38469778/yokenella-regensburgei-infection-in-an-immunocompetent-patient
#17
Luxin Huang, Yeming Chen, Xue Wang
BACKGROUND: Yokenella regensburgei is a gram-negative, opportunistic pathogen that is ubiquitous in natural environments. It commonly affects immunocompromised patients. METHODS: The patient was a 71-year-old female with skin and soft tissue wound caused by trauma. The surgical debridement and abscess drainage were performed by surgeons. The specie of infected organism was identified by the D2Mini semi-automated system and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF)...
March 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38468421/treatment-with-synchronized-radiofrequency-and-facial-muscle-stimulation-histologic-analysis-of-human-skin-for-changes-in-collagen-and-elastin-fibers
#18
JOURNAL ARTICLE
David J Goldberg, Karan Lal
BACKGROUND: Skin's exposure to intrinsic and extrinsic factors causes age-related changes, leading to a lower amount of dermal collagen and elastin. AIM: This study investigated the effects of a novel facial muscle stimulation technology combined with radiofrequency (RF) heating on dermal collagen and elastin content for the treatment of facial wrinkles and skin laxity. METHODS: The active group subjects (N = 6) received four 20-min facial treatments with simultaneous RF and facial muscle stimulation, once weekly...
March 11, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38466482/a-skin-inspired-self-adaptive-system-for-temperature-control-during-dynamic-wound-healing
#19
JOURNAL ARTICLE
Yaqi Geng, Guoyin Chen, Ran Cao, Hongmei Dai, Zexu Hu, Senlong Yu, Le Wang, Liping Zhu, Hengxue Xiang, Meifang Zhu
The thermoregulating function of skin that is capable of maintaining body temperature within a thermostatic state is critical. However, patients suffering from skin damage are struggling with the surrounding scene and situational awareness. Here, we report an interactive self-regulation electronic system by mimicking the human thermos-reception system. The skin-inspired self-adaptive system is composed of two highly sensitive thermistors (thermal-response composite materials), and a low-power temperature control unit (Laser-induced graphene array)...
March 11, 2024: Nano-Micro Letters
https://read.qxmd.com/read/38465786/exploring-the-impact-of-diet-and-nutrition-on-vitiligo-a-systematic-review-of-dietary-factors-and-nutritional-interventions
#20
REVIEW
Zeenat Hadi, Ravneet Kaur, Zahra Parekh, Sukul Khanna, Ahmed Bazil Bin Khalil, Haleema Qayyum Abbasi, Faiza Ashfaque, Dhruvi Shah, Vikaskumar Jitendrakumar Patel, Md Al Hasibuzzaman
BACKGROUND: Vitiligo, an autoimmune skin disorder linked to hormonal and genetic factors, results in reduced pigmentation due to a gradual decline in melanocyte activity. This systematic review delves into the role of dietary intervention and nutrition in managing vitiligo. METHODS: A comprehensive search on PubMed, Google Scholar, and European PMC identified 214 studies, with 14 meeting inclusion criteria post-screening. The selected studies primarily explored the impact of dietary supplements on disease activity...
March 11, 2024: Journal of Cosmetic Dermatology
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