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https://www.readbyqxmd.com/read/29352759/regional-myocardial-function-abnormalities-are-associated-with-macro-and-microcirculation-dysfunction-in-the-metabolic-syndrome-the-resolve-study
#1
Philippe Obert, Guillaume Walther, Frédéric Dutheil, Bruno Lesourd, Robert Chapier, Daniel Courteix, Agnes Vinet
Abnormalities in myocardial and vascular function have been reported in the metabolic syndrome (MetS), but whether these alterations are related remains poorly documented. Our aim was accordingly to investigate interrelationships between macro- and microcirculatory vasoreactivity and left ventricular (LV) myocardial function in MetS patients. Eighty-eight MetS individuals and 44 age- and gender-matched healthy controls were enrolled. LV global longitudinal strain (GLS) was measured using Vector Velocity Imaging...
January 19, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29350880/temporal-and-spatial-quantification-of-pain-related-small-fiber-functionality-assessed-using-laser-speckle-contrast-analysis-lasca
#2
Isin Unal-Cevik
BACKGROUND: This study aimed to establish a practical method for assessing pain symptomatology and develop criteria for quantifying small fiber functions, using LASCA. METHODS: Axon flare responses, which reflect small fiber functions, were induced either by histamine or capsaicin applied to the volar surface of the skin of the left forearm. To inhibit small fiber function, local anesthetic cream was applied to the skin of right forearm. The effects on pain symptomatology (severity/timing) and axon flare responses (temporal/spatial characteristics) were measured using LASCA...
January 19, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29348898/avoiding-thermal-injury-during-near-infrared-photoimmunotherapy-nir-pit-the-importance-of-nir-light-power-density
#3
Shuhei Okuyama, Tadanobu Nagaya, Fusa Ogata, Yasuhiro Maruoka, Kazuhide Sato, Yuko Nakamura, Peter L Choyke, Hisataka Kobayashi
Near-infrared photoimmunotherapy (NIR-PIT) is a newly-established cancer treatment which employs the combination of an antibody-photoabsorber conjugate (APC) and NIR light. When NIR light is absorbed by APC-bound tissues, a certain amount of heat is generated locally. For the most part this results in a subclinical rise in skin temperature, however, excessive light exposure may cause non-specific thermal damage. In this study, we investigated the potential for thermal damage caused by NIR-PIT by measuring surface temperature...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29345019/a-vascular-mechanism-to-explain-thermally-mediated-variations-in-deep-body-cooling-rates-during-the-immersion-of-profoundly-hyperthermic-individuals
#4
Joanne N Caldwell, Anne M J van den Heuvel, Pete Kerry, Mitchell J Clark, Gregory E Peoples, Nigel A S Taylor
Physiologically trivial time differences for cooling the intrathoracic viscera of hyperthermic individuals have been reported between cold- and temperate-water immersion treatments. One explanation for that observation is reduced convective heat delivery to the skin during cold immersion, and this experiment was designed to test both the validity of that observation, and its underlying hypothesis. Eight healthy males participated in four head-out, water immersions: two when normothermic, and two following exercise-induced, moderate-profound hyperthermia...
January 18, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29344436/exploring-laser-induced-breakdown-spectroscopy-as-a-potential-tool-in-mohs-micrography-a-mini-review
#5
REVIEW
Sandeep Singh, Rupak Desai, Mitul Modi, Showket Hussain
Mohs micrographic surgery is the technique of surgically removing skin tumors by gradually excising thin layers and visualizing under a microscope till a tumor-free zone is obtained. During the surgical procedure, visible tumors are surgically removed. During the second stage, if tumor margins are clear with the positive specimen at depth, only depth cavitations need to be done without altering the tumor diameter. Defining the depth during this procedure is a major challenge due to the nonexistence of proper guidelines...
November 13, 2017: Curēus
https://www.readbyqxmd.com/read/29344315/a-topical-anti-inflammatory-healing-regimen-utilizing-conjugated-linolenic-acid-for-use-post-ablative-laser-resurfacing-of-the-face-a-randomized-controlled-trial
#6
Douglas C Wu, Mitchel P Goldman
Background: Fractionated, ablative lasers are usually associated with post-treatment erythema, edema, and crusting, which can last from 5 to 14 days. Conjugated linolenic acid, an omega-5 fatty acid, has significant antioxidant and anti-inflammatory properties, and has been shown to stimulate keratinocyte proliferation and epidermal regeneration. By modulating the early inflammatory milieu and directly affecting skin structure and function, conjugated linolenic acid might therefore shorten downtime following fractionated ablative laser resurfacing of the face...
October 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29340859/comparative-proteomics-of-chromium-transformed-beas-2b-cells-by-2d-dige-and-maldi-tof-tof-ms
#7
Jian Lu, Miaomiao Tang, Yi Liu, Jin Wang, Zhanao Wu
Chromium (Cr) is a highly toxic, common heavy metal used in industrial production. There are two types of Cr in nature: hexavalent chromium (Cr(VI)) and chromium trichloride (Cr(III)). Cr(III) is involved in the metabolism of sugars and lipids, whereas Cr(VI) is absorbed through the respiratory tract and skin and generates free radicals that result in secondary toxicity. Cr(VI) leads to cancer in the occupational population and is therefore recognized as a human carcinogen by the International Agency for Research on Cancer...
January 16, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29340854/therapeutic-efficacy-and-safety-of-a-1927-nm-fractionated-thulium-laser-on-pattern-hair-loss-an-evaluator-blinded-split-scalp-study
#8
Sung Bin Cho, Boncheol Leo Goo, Zhenlong Zheng, Kwang Ho Yoo, Jin-Soo Kang, Heesu Kim
Laser- or light-assisted therapies have been used to improve the perifollicular environment by upregulating the expression of growth factors and signaling molecules for hair restoration. The aim of our study was to preclinically and clinically evaluate the therapeutic efficacy and safety of a 1927-nm fractionated thulium laser on pattern hair loss (PHL). An in vivo hairless mouse study and an in vivo human skin environmental scanning electron microscopy (ESEM) study were performed with different power and energy settings...
January 16, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29338981/reproducibility-and-agreement-of-different-non-invasive-methods-of-endothelial-function-assessment
#9
Khatera Ibrahimi, Young De Graaf, Richard Draijer, A H Jan Danser, Antoinette Maassen VanDenBrink, Anton H van den Meiracker
Flow-mediated dilatation (FMD) is an established, but investigator-demanding method, used to non-invasively determine nitric oxide (NO)-dependent endothelial function in humans. Local thermal hyperemia (LTH) or post-occlusive reactive hyperemia (PORH) of the skin measured with a laser Doppler flow imager may be a less demanding alternative of FMD. We investigated the reproducibility of the different measures of vascular function, their interrelationship and the NO-dependency of LTH. Measurements were performed twice in 27 healthy men (8 smokers), one week apart...
January 12, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29337704/the-what-when-and-how-in-performing-and-interpreting-microbiological-diagnostic-tests-in-skin-and-soft-tissue-infections
#10
Carolina Navarro-San Francisco, Patricia Ruiz-Garbajosa, Rafael Cantón
PURPOSE OF REVIEW: To summarize and classify the most recent and relevant microbiological studies for each type of skin and soft tissue infection (SSTI). RECENT FINDINGS: Following Infectious Diseases Society of America and Food and Drug Administration classifications of SSTIs, we differentiate between two large groups, the superficial or uncomplicated infections and the complicated infections with deep involvement. It is not usually necessary to obtain microbiological samples in uncomplicated infections, except in cases of recurrences or for epidemiological control purposes...
January 11, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29336034/quantitative-evaluation-of-collagen-and-elastic-fibers-after-intense-pulsed-light-treatment-of-mouse-skin
#11
Luciana L Faucz, Sonia E Will, Consuelo J Rodrigues, Henrique Hesse, Angelina C Moraes, Durvanei A Maria
BACKGROUND AND OBJECTIVE: The aging of human skin includes intrinsic aging and photo-aging, which are characterized by a decrease in collagen and the deposition of abnormal elastic fibers. Intense pulsed light (IPL) sources are widely used in medicine to treat various cosmetic problems, including photo-damaged skin. Few studies have examined the microscopic changes produced by IPL. The objective of this study was to quantitatively evaluate the effects of IPL on collagen and elastic fibers in mice...
January 16, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29331035/noninvasive-optical-spectroscopy-for-identification-of-non-melanoma-skin-cancer-pilot-study
#12
David J Carpenter, Mirabelle B Sajisevi, Nikita Chapurin, Clifford Scott Brown, Tracy Cheng, Gregory M Palmer, Daniel S Stevenson, Caroline L Rao, Russell P Hall, Charles R Woodard
OBJECTIVE: Optical spectroscopy offers a noninvasive alternative to biopsy as a first-line screening tool for suspicious skin lesions. This study sought to define several optical parameters across malignant and benign tissue types. STUDY DESIGN: Prospective pilot trial utilizing the Zenalux IM1 optical spectroscopy device from April 2016 to February 2017. For each skin lesion, provider pre-biopsy probability of malignancy was compared to histolopathologic diagnosis...
January 13, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29328106/polymer-thermal-optical-switch-for-a-flexible-photonic-circuit
#13
Yue Sun, Yue Cao, Qi Wang, Yunji Yi, Xiaoqiang Sun, Yuanda Wu, Fei Wang, Daming Zhang
Flexible and wearable optoelectronic devices are the new trend for an active lifestyle. These devices are polymer-based for flexibility. We demonstrated flexible polymer waveguide optical switches for a flexible photonic integrated circuit. The optical switches are composed of a single-mode inverted waveguide with dimensions of 5 μm waveguide width, 3 μm ridge height, and 3 μm slab height. A Mach-Zehnder structure was used in the device, with the Y-branch horizontal length of 0.1 cm, the distance between two heating branches of 30 μm, and the heating branch length of 1 cm...
January 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29322633/preclinical-evaluation-of-melanocyte-transplantation-by-chitosan-based-melanocyte-spheroid-patch-to-skin-prepared-by-controlled-sunburn-blistering
#14
Sabrina Mai-Yi Fan, Po-Hua Chen, Yu-Ting Tseng, Jin-Bon Hong, Wannhsin Chen, Tsen-Fang Tsai, Sung-Jan Lin
Transplantation of autologous cultured melanocytes as cell suspension has been used for the treatment of vitiligo. The recipient site is often prepared by laser-mediated dermabrasion. Such procedures encounter disadvantages including prolonged transplantation duration, unsecured cell adherence to lesional skin and potential scarring. To improve this, here we propose a method by preparing recipient sites before transplantation by psoralen and ultraviolet A (PUVA)-induced sunburn followed by transplanting cells with a chitosan-based melanocyte spheroid patch...
January 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29322537/comparative-evaluations-of-hypertrophic-scar-formation-in-in-vivo-models
#15
Myeongjin Kim, Hyejin Kim, Hyun Wook Kang
BACKGROUND AND OBJECTIVE: Hypertrophic scar (HTS) results from a connective tissue reaction to trauma, inflammation, surgery, or burn on skin. In spite of various techniques for wound generation, the degree of scar in animal models after healing is still unpredictable and less reproducible. The objective of the current study was to identify the appropriate method to create the maximal HTS tissue in a reliable manner by comparing three different methods in vivo. MATERIALS AND METHODS: A 27 ICR mice were tested for the in vivo evaluations...
January 11, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29320595/safety-and-efficacy-of-a-non-invasive-1060-nm-diode-laser-for-fat-reduction-of-the-abdomen
#16
Lawrence S Bass, Sean T Doherty
BACKGROUND: Changes in temperature are known to produce apoptosis in adipocytes. This study examines the use of a non-invasive treatment that applies 1060 nm laser energy transcutaneously to hyperthermically induce disruption of fat cells in the abdomen. METHODS: Thirty-five subjects received application of 1060 nm laser on the abdomen for fat reduction. Ultrasound images and high-resolution two-dimensional photography were recorded at baseline, 6 weeks, and 12 weeks post treatment...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29320586/safety-and-efficacy-of-a-1550nm-1927nm-dual-wavelength-laser-for-the-treatment-of-photodamaged-skin
#17
Vic A Narurkar, Tina S Alster, Eric F Bernstein, Tina J Lin, Anya Loncaric
<p>BACKGROUND: Fractional photothermolysis (FP) is a popular treatment option for photodamaged skin and addresses shortcomings of ablative skin resurfacing and nonablative dermal remodeling. Previous studies have demonstrated that FP using the 1550nm wavelength has led to improvement of ultrastructural changes and clinical effects associated with photodamaged skin in the deeper dermal structures, while treatment with the 1927nm wavelength has shown clinical effects in the superficial dermis. Both wavelengths produce precise microscopic treatment zones (MTZs) in the skin...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29317818/antibacterial-mechanisms-of-a-novel-type-picosecond-laser-generated-silver-titanium-nanoparticles-and-their-toxicity-to-human-cells
#18
Peri Korshed, Lin Li, Zhu Liu, Aleksandr Mironov, Tao Wang
In this study, we explored the antibacterial mechanisms for a novel type of Ag-TiO2 compound nanoparticles (NPs) produced from an Ag-TiO2 alloy using a picosecond laser and evaluated the toxicity of the Ag-TiO2 NPs to a range of human cell types. Transmission electron microscopy was used to determine the morphology, shapes, and size distribution of the laser-generated Ag-TiO2 NPs. UV-visible spectrometer was used to confirm the shift of light absorbance of the NPs toward visible light wavelength. Results showed that the laser-generated Ag-TiO2 NPs had significant antibacterial activities against both Gram-negative and Gram-positive bacterial strains, including Escherichia coli, Pseudomonas aeruginosa, and the methicillin-resistant Staphylococcus aureus...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29316829/effects-of-carbomer-940-hydrogel-on-burn-wounds-an-in-vitro-and-in-vivo-study
#19
Farzad Hayati, Seyed Mehdi Ghamsari, Mohammad Mehdi Dehghan, Ahmad Oryan
PURPOSE: This study was designed to investigate the applicability of carbomer 940 hydrogel on skin-burn wounds by focusing on its effects on the zone of stasis. METHOD: Fibroblast cells were used to assess the cytotoxicity of carbomer 940. Wound healing was monitored by laser Doppler flowmetry and histopathological analysis. Twenty adult male Wistar rats were randomly divided into two groups (N = 10 each). After shaving their dorsum, a "burn comb" was contacted bilaterally on each side of the spine...
January 10, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29316678/actinic-keratosis-and-non-invasive-diagnostic-techniques-an-update
#20
REVIEW
Alice Casari, Johanna Chester, Giovanni Pellacani
Actinic keratosis represents the earliest manifestation of non-melanoma skin cancer. Because of their risk of progression to invasive squamous cell carcinoma, an earlier diagnosis and treatment are mandatory. Their diagnosis sometimes could represent a challenge even for expert dermatologists. Dermoscopy, confocal laser microscopy and optical coherence tomography could help clinicians in diagnosis.
January 8, 2018: Biomedicines
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