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https://www.readbyqxmd.com/read/29775714/novel-bletilla-striata-polysaccharide-microneedles-fabrication-characterization-and-in-vitro-transcutaneous-drug-delivery
#1
Lingli Hu, Zhencheng Liao, Qiqi Hu, Katherine G Maffucci, Yan Qu
Dissolving microneedles (MNs) have been widely studied for their applications in effective transdermal drug delivery due to their ability to dissolve within the skin. This study details the first reported successful preparation of novel dissolving MNs using Bletilla striata polysaccharide (BSP), a natural glucomannan material, and investigates the potential for using such MNs as a transdermal drug delivery vector. The prepared dissolving Bletilla striata polysaccharide microneedles (BMNs) had excellent moldability and were easily detached from the mold...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29774372/-optical-coherence-tomography-for-skin-pathologies
#2
REVIEW
J Welzel, S Schuh
Optical coherence tomography (OCT) has become established in routine diagnosis in dermatology only in the last few years. The reason is that the skin is a challenge for OCT as a strong scattering medium, because only a very small proportion of photons is reflected and can be used for imaging. In addition, in most cases a visual assessment or a biopsy is sufficient. Nevertheless, the main field of application in dermatology is the diagnostics of epithelial skin tumors. The OCT is suitable for the early recognition of small, clinically and light microscopically unspecific basal cell carcinomas as well as for the differential diagnosis of other tumors and precancerous lesions...
May 17, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29767718/prediction-of-treatment-outcomes-for-neck-rejuvenation-utilizing-a-unique-classification-system-of-treatment-approach-using-a-1440-nm-side-firing-laser
#3
Gabriella A DiBernardo, Barry E DiBernardo
Background: The appearance of a youthful neck is lost with age causing excessive skin laxity, a loss of subcutaneous fat, prominence of platysmal banding, and jowling. In view of the success obtained with laser treatment for neck rejuvenation, the authors have recently taken an algorithmic approach to developing a 7-category classification system of the aging conditions throughout the anatomic spectrum of three areas: skin, fat, and muscle. This system will correlate with specific treatment options...
May 15, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29766626/co-2-laser-and-photodynamic-therapy-study-of-efficacy-in-periocular-bcc
#4
Santo Raffaele Mercuri, Pina Brianti, Annunziata Dattola, Luigi Bennardo, Martina Silvestri, Giusy Schipani, Steven Paul Nisticò
Basal cell carcinoma (BCC), the most common type of skin cancer in the world, usually arises in sun-exposed areas of the skin. The therapeutic approach to periocular BCC has changed in the last few years. Currently the treatment, considering the delicate localization of the disease, must not only ensure complete recovery from the neoplastic disease, but must also satisfy functional and aesthetic criteria. In this study we tried to evaluate the efficacy of CO2 laser and photodynamic therapy in periocular BCC...
May 15, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29766207/risks-and-prevention-of-surgical-fires-a-systematic-review
#5
I Kezze, N Zoremba, R Rossaint, A Rieg, M Coburn, G Schälte
Surgically induced fire is a life-threatening hazard; this topic has received little attention, although only 3 factors, the so-called fire triad, are needed for surgical fires to occur: an oxidizer, fuel and an ignition source. This systematic review aims to determine the impact of each component and to delegate every staff member an area of responsibility, thus ensuring patient health through prevention or protection. The trial was registered in Prospero CRD42018082656. A database search of eligible, preferably evidence-based studies was conducted...
May 15, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29764244/kinetics-and-tissue-repair-process-following-fractional-bipolar-radiofrequency-treatment
#6
G Kokolakis, L von Eichel, M Ulrich, J Lademann, T Zuberbier, M A Hofmann
INTRODUCTION: Fractionated radiofrequency (RF) tissue tightening is an alternative method to fractionated laser treatment of skin wrinkling, laxity and acne scars, with reduced risk of scarring or persistent pigmentation. The aim of this study was to evaluate and quantify the wound healing process after RF treatment. MATERIALS AND METHODS: 12 patients were treated with a 64-pin fractional bipolar RF device with 60 mJ/pin applied energy. Confocal laser scanning microscopy (CLSM) examination was performed on day 1, day 2, day 7 and day 14 after treatment...
May 15, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29757022/clinical-outcome-of-1064-nm-picosecond-neodymium-doped-yttrium-aluminium-garnet-laser-for-the-treatment-of-hypertrophic-scars
#7
Young-Jun Choi, Jung Yup Kim, Jae-Hui Nam, Ga-Young Lee, Won-Serk Kim
BACKGROUND: Currently no study has evaluated the effect of the novel 1064-nm picosecond neodymium-doped:yttrium aluminium garnet laser (ps-Nd:YAG) for reducing Hypertrophic scarring (HS). OBJECTIVE: The aim of this study was to verify the efficacy and safety of a 1064-nm ps-Nd:YAG in the management of HS. MATERIALS AND METHODS: A retrospective chart review and photographic analysis were conducted on patients treated with a low-fluence 1064-nm ps-Nd:YAG for HS improvement...
May 14, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29756651/optical-signature-of-nerve-tissue-exploratory-ex-vivo-study-comparing-optical-histological-and-molecular-characteristics-of-different-adipose-and-nerve-tissues
#8
Andrea J R Balthasar, Torre M Bydlon, Hans Ippel, Marjolein van der Voort, Benno H W Hendriks, Gerald W Lucassen, Geert-Jan van Geffen, Maarten van Kleef, Paul van Dijk, Arno Lataster
BACKGROUND: During several anesthesiological procedures, needles are inserted through the skin of a patient to target nerves. In most cases, the needle traverses several tissues-skin, subcutaneous adipose tissue, muscles, nerves, and blood vessels-to reach the target nerve. A clear identification of the target nerve can improve the success of the nerve block and reduce the rate of complications. This may be accomplished with diffuse reflectance spectroscopy (DRS) which can provide a quantitative measure of the tissue composition...
May 14, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29755850/three-dimensional-printing-and-cell-therapy-for-wound-repair
#9
REVIEW
Sylvia van Kogelenberg, Zhilian Yue, Jeremy N Dinoro, Christopher S Baker, Gordon G Wallace
Significance: Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach to regenerative medicine, whereby cells and cell-based materials can be dispensed in fine spatial arrangements to mimic native tissue. Recent Advances: Various bioprinting techniques have been employed in wound repair-based skin tissue engineering, from laser-induced forward transfer to extrusion-based methods, and with the investigation of the benefits and shortcomings of each, with emphasis on biological compatibility and cell proliferation, migration, and vitality...
May 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29753516/is-endothelial-microvascular-function-equally-impaired-among-patients-with-chronic-chagas-and-ischemic-cardiomyopathy
#10
Juliana Pereira Borges, Fernanda de Souza Nogueira Sardinha Mendes, Gabriella de Oliveira Lopes, Andréa Silvestre de Sousa, Mauro Felippe Felix Mediano, Eduardo Tibiriçá
BACKGROUND: Chronic Chagas cardiomyopathy (CCC) and cardiomyopathies due to other etiologies involve differences in pathophysiological pathways that are still unclear. Systemic microvascular abnormalities are associated with the pathogenesis of ischemic heart disease. However, systemic microvascular endothelial function in CCC remains to be elucidated. Thus, we compared the microvascular endothelial function of patients presenting with CCC to those with ischemic cardiomyopathy disease...
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29752665/microcirculatory-improvement-induced-by-laparoscopic-sleeve-gastrectomy-is-related-to-insulin-sensitivity-retrieval
#11
Stefano Ministrini, Chiara Fattori, Maria Anastasia Ricci, Vanessa Bianconi, Rita Paltriccia, Marcello Boni, Maria Teresa Paganelli, Gaetano Vaudo, Graziana Lupattelli, Leonella Pasqualini
AIMS: Microvascular dysfunction is a potential factor explaining the association of obesity, insulin resistance, and vascular damage in morbidly obese subjects. The purpose of the study was to evaluate possible determinants of microcirculatory improvement 1 year after laparoscopic sleeve gastrectomy (LSG) intervention. METHODS: Thirty-seven morbidly obese subjects eligible for bariatric surgery were included in the study. Post-occlusive reactive hyperemia (PORH) of the forearm skin was measured as area of hyperemia (AH) by laser-Doppler flowmetry before LSG and after a 1-year follow-up...
May 12, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29750765/ideal-and-actual-impact-of-rapid-diagnostic-testing-and-antibiotic-stewardship-on-antibiotic-prescribing-and-clinical-outcomes-in-children-with-positive-blood-cultures
#12
Caroline H Reuter, Hannah L Palac, Larry K Kociolek, Xiaotian T Zheng, Yusuf Y Chao, Rupal Patel, Sameer J Patel
BACKGROUND: Implementing matrix assisted laser desorption ionization time of flight (MALDI-TOF) and multiplex PCR (mPCR) has been associated with decreased mortality and hospital length of stay in adults, but the impact in pediatrics is less understood. METHODS: This pre-post quasi-experimental study compared antibiotic prescribing for positive blood cultures in patients ≤21 years collected in 2012 (pre-intervention) and in 2015 (after MALDI-TOF/mPCR). Time to effective and optimal antimicrobial therapy were evaluated using Cox proportional hazards regression...
May 10, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29749938/impact-of-abandoned-leads-on-cardiovascular-implantable-electronic-device-infections-a-propensity-matched-analysis-of-medic-multicenter-electrophysiologic-device-infection-cohort
#13
Thomas A Boyle, Daniel Z Uslan, Jordan M Prutkin, Arnold J Greenspon, Larry M Baddour, Stephan B Danik, Jose M Tolosana, Katherine Le, Jose M Miro, James E Peacock, Muhammad R Sohail, Holenarasipur R Vikram, Roger G Carrillo
OBJECTIVES: This study sought to evaluate the impact of abandoned cardiovascular implantable electronic device (CIED) leads on the presentation and management of device-related infections. BACKGROUND: Device infection is a serious consequence of CIEDs and necessitates removal of all hardware for attempted cure. The merits of extracting or retaining presumed sterile but nonfunctioning leads is a subject of ongoing debate. METHODS: The MEDIC (Multicenter Electrophysiologic Device Infection Cohort) prospectively enrolled patients with CIED infections at 10 institutions in the United States and abroad between January 1, 2009, and December 31, 2012...
February 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29744784/acne-scarring-management-systematic-review-and-evaluation-of-the-evidence
#14
REVIEW
Shashank Bhargava, Paulo R Cunha, Jennifer Lee, George Kroumpouzos
BACKGROUND: Modalities for atrophic acne scarring can be classified depending upon the needs they satisfy; that is, resurfacing, lifting/volumization, tightening, or surgical removal/movement of tissue that is required for correction. A plethora of treatment options have resulted from the need to treat various acne scar types, variability of responses noted in various skin types, and increasing popularity of minimally invasive modalities. Still, there is a lack of consensus guidelines on treatment or combination therapies for various clinical scenarios...
May 9, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29744754/less-is-more-similar-efficacy-in-three-sessions-and-seven-sessions-of-pulsed-dye-laser-treatment-in-infantile-port-wine-stain-patients
#15
Jiafang Zhu, Wenxin Yu, Tianyou Wang, Yijie Chen, Dongze Lyu, Lei Chang, Gang Ma, Xiaoxi Lin
Port-wine stains (PWS) affect 0.3 to 0.5% of newborns and pulsed dye laser (PDL) remains the treatment of choice. However, no reliable study regarding the benefits of more frequent has been conducted. We designed the present study to evaluate whether more frequent PDL treatments in infantile patients would achieve further lightening of erythema. We prospectively investigated 20 infants with PWS. Two adjacent sites were both treated for a 12-week duration and randomly allocated to be treated for seven sessions at 2-week intervals or three sessions at 6-week intervals...
May 10, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29744385/changes-in-blood-flow-at-the-mandibular-angle-and-horner-syndrome-in-a-rat-model-of-superior-cervical-ganglion-block
#16
Kazutoshi Kubota, Katsuhisa Sunada
Background: A stellate ganglion block (SGB) causes increased blood flow in the maxillofacial region, exhibiting the potential for regenerative effects in damaged tissue. The focus of this study was to understand the efficacy of SGB for regenerative effects against nerve damage. A rat model of the superior cervical ganglion block (SCGB) was created instead of SGB, and facial blood flow, as well as sympathetic nervous system function, were measured. Methods: A vertical incision was made on the left side of the neck of a Wistar rat, and a 5-mm resection of the superior cervical ganglion was performed at the back of the bifurcation of the internal and external branches of the left common carotid artery...
April 2018: Journal of Dental Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29742179/demographic-and-tumor-characteristics-of-patients-younger-than-50-years-with-nonmelanoma-skin-cancer-referred-for-mohs-micrographic-surgery
#17
Nicola A Quatrano, Euphemia W Mu, David E Orbuch, Adele Haimovic, Roy G Geronemus, Jeremy A Brauer
BACKGROUND: An increase in nonmelanoma skin cancer (NMSC) in younger patients has been reported. Many are treated with Mohs micrographic surgery (MMS). OBJECTIVE: Investigate patient and tumor characteristics in patients less than 50 years undergoing MMS for NMSC at a large, referral-based practice. METHODS & MATERIALS: Retrospective chart review of 1,332 tumors occurring in 1,018 consecutive patients over a five-year period. RESULTS: 81...
May 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29740880/fundamental-supply-of-skin-blood-flow-in-the-chinese-han-population-measurements-by-a-full-field-laser-perfusion-imager
#18
W Fei, S Xu, J Ma, W Zhai, S Cheng, Y Chang, X Wang, J Gao, H Tang, S Yang, X Zhang
BACKGROUND: Skin blood flow is believed to link with many diseases, and shows a significant heterogeneity. There are several papers on basal cutaneous microcirculation perfusion in different races, while the data in Chinese is vacant. OBJECTIVE: The aim was to establish the database of absolute fundamental supply of skin blood flow in the Chinese Han population. METHODS: With a full-field laser perfusion imager (FLPI), the skin blood flow can be quantified...
May 8, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29740104/setup-errors-and-effectiveness-of-optical-laser-3d-surface-imaging-system-sentinel-in-postoperative-radiotherapy-of-breast-cancer
#19
Xiaobo Wei, Mengjiao Liu, Yun Ding, Qilin Li, Changhai Cheng, Xian Zong, Wenming Yin, Jie Chen, Wendong Gu
Breast-conserving surgery (BCS) plus postoperative radiotherapy has become the standard treatment for early-stage breast cancer. The aim of this study was to compare the setup accuracy of optical surface imaging by the Sentinel system with cone-beam computerized tomography (CBCT) imaging currently used in our clinic for patients received BCS. Two optical surface scans were acquired before and immediately after couch movement correction. The correlation between the setup errors as determined by the initial optical surface scan and CBCT was analyzed...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737551/whole-body-and-local-hyperthermia-enhances-the-photosensitizing-efficacy-of-3-1-hexyloxy-ethyl-3-devinylpyropheophorbide-a-hpph
#20
Avinash Srivatsan, Arindam Sen, Ravindra R Cheruku, Joseph R Missert, Farukh A Durrani, Khurshid Guru, Ravindra K Pandey
BACKGROUND AND OBJECTIVES: In this study, we evaluated the impact of hyperthermia in photosensitizing efficacy of 3-[(1'-hexyloxy)ethyl-3-devinylpyropheophorbide-a (HPPH or Photochlor) for the treatment of cancer by photodynamic therapy (PDT). STUDY DESIGN/MATERIALS AND METHODS: The outcome of both whole body hyperthermia (WBH) and local hyperthermia (LH) in combination with HPPH-PDT was determined in BALB/c and nude mice bearing Colon26 and U87 tumors, respectively...
May 8, 2018: Lasers in Surgery and Medicine
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