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https://www.readbyqxmd.com/read/29681960/first-uses-of-haart-300-rings-for-aortic-valve-repair-in-poland-4-case-studies
#1
Jacek H Juściński, Andrzej Koprowski, Magdalena Kołaczkowska, Maciej M Kowalik, Jan A Rogowski, James S Rankin
Introduction: Aortic valve reconstructions using geometric annuloplasty rings HAART 300/200 open new era in aortic valve surgery. The HAART technology resizes, reshapes, stabilizes and simplifies aortic valve repair. The HAART aortic repair rings are designed to be implanted directly into aortic annulus (under aortic valve leaflets). Aim: We present first in Poland 4 cases of aortic valve reconstructions using geometric annuloplasty rings HAART 300. Material and methods: Two patients had type IA aortic insufficiency (due to El-Khoury classification) - they were treated by HAART 300 ring insertion and ascending aorta prosthesis implantation...
March 2018: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/29676342/audit-of-prevention-of-mother-to-child-transmission-programme-interventions-in-hiv-exposed-children-at-national-hospital-abuja-nigeria
#2
Mariya Mukhtar-Yola, Adekunle Tolulope Otuneye, Amsa Baba Mairami, Yewande Wey, Vincent Nwatah, Lamidi Isah Audu
Background: Ninety percentage of children acquire human immunodeficiency virus (HIV) infection in the form of Mother-to-child Transmission (MTCT). In the absence of interventions, transmission rates range from 15% to 45%. This can be reduced to below 5% with effective interventions. The last published national guideline (NG) on prevention of MTCT (PMTCT) was in 2010. Clinical audits are essential in improving the quality of care delivered to patients. Objectives: The study objectives were to determine the rate of MTCT of HIV in exposed infants at a follow-up clinic between 2011 and 2014 and to determine the level of adherence to 2010 NG on the use of highly active antiretroviral therapy (HAART), polymerase chain reaction (PCR) testing, feeding options, antiretroviral (ARV) prophylaxis and the use of co-trimoxazole (CTZ)...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29674001/in-vitro-assessment-of-competitive-and-time-dependent-inhibition-of-the-nevirapine-metabolism-by-nortriptyline-in-rats
#3
Iris Usach, José-Maria Ferrer, José-Esteban Peris
Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) widely used as a component of High Active Antiretroviral Therapy (HAART) since it is inexpensive, readily absorbed after oral administration and non-teratogenic. In the present work, the mechanism of a previously described pharmacokinetic interaction between NVP and the antidepressant drug nortriptyline (NT) was studied using rat hepatic microsomes. The obtained results showed a competitive inhibition of the NVP metabolism by NT...
April 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29670213/quercetin-attenuates-azt-induced-neuroinflammation-in-the-cns
#4
Yi Yang, Xiaokang Liu, Ting Wu, Wenping Zhang, Jianhong Shu, Yulong He, Shao-Jun Tang
Highly active anti-retroviral therapy (HAART) is very effective in suppressing HIV-1 replication in patients. However, continuous HAART is required to prevent viral rebound, which may have detrimental effects in various tissues, including persistent neuroinflammation in the central nervous system (CNS). Here, we show that quercetin (3,5,7,3',4'-pentahydroxy flavones), a natural antioxidant used in Chinese traditional medicines, suppresses the neuroinflammation that is induced by chronic exposure to Zidovudine (azidothymidine, AZT), a nucleoside reverse transcriptase inhibitor (NRTI) that is commonly part of HAART regimens...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669485/perioperative-outcomes-in-human-immunodeficiency-virus-infected-patients-the-pro-hiv-study
#5
Divyashree Shanthamurthy, Abi Manesh, Naveena Gp Zacchaeus, Lisa R Roy, Priscilla Rupali
It is estimated that a quarter of patients with HIV/AIDS undergo at least one surgical procedure in their life time. Surgical outcomes in these patients from developing countries are poorly characterized and surgeons are often concerned about poor surgical outcomes, especially when their CD4 cell counts are less than 200 cells/µl. This study evaluated the surgical outcomes of HIV-infected patients undergoing various surgical procedures over a six-year period in a large tertiary care hospital from South India...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29656849/association-of-highly-active-antiretroviral-treatment-with-incident-tuberculosis-in-people-living-with-hiv-aids
#6
Yung-Feng Yen, I-An Jen, Pei-Hung Chuang, Marcelo Chen, Yu-Ching Lan, Chun-Yuan Lee, Yi-Ming Arthur Chen
PURPOSE: To determine the short-term and long-term effects of highly active antiretroviral therapy (HAART) on incident tuberculosis (TB) in people living with HIV/AIDS (PLWHA). METHODS: From 2000 to 2012, we identified adult PLWHA from Taiwan Centers for Disease Control HIV Surveillance System. All PLWHA were followed up until December 31, 2012, and observed for TB occurrence. Time-dependent Cox proportional hazards models were used to determine the short-term and long-term effects of HAART on incident TB...
March 28, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29652971/-factors-associated-to-survival-in-patients-with-hiv-tb-in-the-department-of-infectious-diseases-of-the-arzobispo-loayza-national-hospital-per%C3%A3%C2%BA-since-2004-to-2012
#7
Brenda Gamboa-Acuña, Rayza Guillén-Zambrano, Grecia Lizzetti-Mendoza, Alonso Soto, Aldo Lucchetti-Rodríguez
Background The main cause of death in HIV patients is tuberculosis (TB). However, few Latin American studies have evaluated the prognosis of patients with coinfection. Aim To determine the factors associated with survival in patients with HIV-TB coinfection treated at a Peruvian referral hospital. Methods A retrospective cohort study was performed based on clinical records of patients treated at the Department of Infectious Diseases in the Arzobispo Loayza National Hospital from 2004 to 2012. Survival was assessed using the Kaplan-Meier estimator and Cox Proportional Hazard Model...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29649107/impaired-hematologic-status-in-relation-to-clinical-outcomes-among-hiv-infected-adults-from-uganda-a-prospective-cohort-study
#8
Amara E Ezeamama, David Guwatudde, Alla Sikorskii, Edmond K Kabagambe, Raybun Spelts, Grace Vahey, Jenifer I Fenton, Wafaie W Fawzi
Impaired hematologic status (IHS) was investigated as a determinant of immune function defined as cluster of differentiation 4 (CD4) T-helper cell count, quality of life (QOL) weight and hospitalization/mortality over 18-months among 398 adult persons living with HIV/AIDS (PLWHA) on anti-retroviral therapy. IHS was defined as having anemia at baseline (Hemoglobin: <12 g/dL for women and <13 g/dL for men), time-updated anemia or having low (<30 μg/L) or high (>200 μg/L for men and >150 μg/L for women) ferritin levels at baseline...
April 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29649077/circulating-cxcr5-expressing-cd8-t-cells-are-major-producers-of-il-21-and-associate-with-limited-hiv-replication
#9
Federico Perdomo-Celis, Natalia A Taborda, Maria T Rugeles
BACKGROUND: Despite advances made with the highly active anti-retroviral therapy (HAART) in the control of the human immunodeficiency virus 1 (HIV) infection, a cure has not been achieved due to the persistence of viral reservoirs. The major HIV reservoirs remain in the lymphoid follicles due to, among other factors, the partial absence of CD8T-cells in these structures. Recently, lymphoid follicle-confined and circulating CD8T-cells expressing the C-X-C chemokine receptor type 5 (CXCR5) were described, possessing antiviral mechanisms which could help to control HIV replication...
April 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29630136/body-fat-changes-in-hiv-patients-on-highly-active-antiretroviral-therapy-haart-a-longitudinal-dexa-study
#10
S Nuvoli, G Caruana, S Babudieri, P Solinas, G Pellicanò, B Piras, V Fiore, P Bagella, G M Calia, M Yue, A Spanu, G Madeddu
OBJECTIVE: We aimed to quantitatively evaluate body fat composition in a group of HIV patients treated with Highly Active Anti-retroviral Therapy (HAART) to ascertain both fat loss and fat distribution changes and to identify possible therapeutic and host related associated risk factors. PATIENTS AND METHODS: A total of 180 patients with available total body DEXA scan were assigned to a) Group 1, with clinically evident body fat changes, (BFC) and b) Group 2, without BFC...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29624952/an-audit-of-perineal-trauma-and-vertical-transmisson-of-hiv
#11
Amaka N Ocheke, Ephraim Samuels, Isaac E Ocheke, Patricia A Agaba, Clement Ekere, James Bitrus, Emmanuel I Agaba, Atiene S Sagay
Restrictive episiotomy is recommended for the prevention of vertical transmission of HIV. The study compared the frequency of episiotomy use and the occurrence of perineal tears; and related factors in HIV positive and HIV negative women and to assess their effect on Mother-to-child transmission (MTCT) of HIV. A total of 110 HIV positive and 134 HIV negative parturients were enrolled in the study. The incidence of episiotomy was more in the HIV negative group (p=0.0000) while that of perineal tear was not affected by HIV status (p=0...
December 2017: African Journal of Reproductive Health
https://www.readbyqxmd.com/read/29616943/malnutrition-risk-depression-and-weight-status-among-hiv-positive-patients-under-haart
#12
Panagiotis Provias, Aleks Pepa, Maria G Grammatikopoulou, Xenophon Theodoridis, Ilias Tirodimos, Theodore Dardavessis, Michael Chourdakis
No abstract text is available yet for this article.
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29616646/morbidity-and-mortality-in-hiv-infected-children-on-antiretroviral-therapy-in-togo
#13
A Mouhari-Touré, G Mahamadou, K Kombate, A S Akakpo, J N Teclessou, A Singo, P Pitché
the aim of this study was to evaluate the mortality and morbidity of HIV-infected children on highly active antiretroviral treatment (HAART) in Togo. this is a retrospective study of HIV-infected children on HAART in the 25 largest centers of HIV/AIDS care in Togo. the study included 1861 children (sex-ratio=0.99). Among them, 35.6 % were in WHO clinical stages 3 or 4 at the beginning of HAART. The most common opportunistic infections were coughing and pneumonia (37.1 %), gastroenteritis (11.3 %), various bacterial infections (10...
February 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29610680/association-between-cd4-cell-count-and-blood-pressure-and-its-variation-with-body-mass-index-categories-in-hiv-infected-patients
#14
Christian Akem Dimala, Benjamin Momo Kadia, Ben-Lawrence Kemah, Maxime Tindong, Simeon-Pierre Choukem
The aim of this study was to establish whether an independent relationship exists between CD4 count and hypertension and if this relationship is modified or confounded by the body mass index (BMI). Methods . A secondary data analysis of a cross-sectional study on 200 HIV/AIDS patients at a referral hospital in Cameroon was conducted. Linear and logistic regression models were used as appropriate to explore the association between the variables of interest. Results . There was no linear association between log CD4 count and both systolic ( p = 0...
2018: International Journal of Hypertension
https://www.readbyqxmd.com/read/29607354/consequence-of-hiv-and-hcv-co-infection-on-host-immune-response-persistence-and-current-treatment-options
#15
REVIEW
Sayed Sartaj Sohrab, Mohd Suhail, Ashraf Ali, Ishtiaq Qadri, Steve Harakeh, Esam I Azhar
Hepatitis C virus (HCV) is a common opportunistic pathogen especially among Human immunodeficiency virus (HIV) infected patients. Due to incongruous studies, the pathological effect of HCV on HIV induced disease are still not fully understood. While some studies have showed no effect of HCV on HIV infection, others reported a defined role of HCV in aggravating the rates of AIDS-related illnesses and mortality. The explanation of such variances may be due to the host immune response, viral genotypes, sub-type and quasi-species distribution...
March 2018: Virusdisease
https://www.readbyqxmd.com/read/29605279/epstein-barr-virus-associated-smooth-muscle-tumor-involving-the-spine-of-an-hiv-infected-patient-case-report-and-review-of-the-literature
#16
Jeffrey S Ehresman, A Karim Ahmed, Doreen N Palsgrove, Zachary Pennington, C Rory Goodwin, Daniel M Sciubba
Within the last two decades, there have been multiple reports of Epstein-Barr virus (EBV)-associated smooth muscle tumors in immunocompromised patients. This includes HIV-infected patients, post-transplant patients, and patients with congenital defects of their immune systems. Here we report the case of a 24-year-old African American female with congenital HIV presenting with progressive lower extremity weakness, constipation, aching pain in her shoulders, and subcostal anesthesia. Magnetic resonance imaging (MRI) revealed a large circumferential lesion extending from T1-T3 and a smaller left paraspinal lesion at C6-C7...
March 28, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29601578/hiv-induces-production-of-il-18-from-intestinal-epithelial-cells-that-increases-intestinal-permeability-and-microbial-translocation
#17
Ossama Allam, Suzanne Samarani, Vikram Mehraj, Mohammad-Ali Jenabian, Cecile Tremblay, Jean-Pierre Routy, Devendra Amre, Ali Ahmad
Interleukin-18 (IL-18) is a pleiotropic cytokine of the IL-1 family with multiple context dependent functions. We and others have shown that HIV infection is accompanied by increased circulating levels of IL-18 along with decreased levels of its antagonist, Interleukin-18 Binding Protein (IL-18BP). The infection is also accompanied by intestinal inflammation and decreased intestinal integrity as measured by intestinal permeability, regeneration and repair. However, little is known concerning the relation between high level of IL-18 associated with the viral infection and intestinal permeability...
2018: PloS One
https://www.readbyqxmd.com/read/29597116/elevated-serum-uric-acid-levels-are-associated-with-endothelial-dysfunction-in-hiv-patients-receiving-highly-active-antiretroviral-therapy
#18
Matteo Pirro, Vanessa Bianconi, Elisabetta Schiaroli, Daniela Francisci, Massimo R Mannarino, Francesco Bagaglia, Amirhossein Sahebkar, Tony Merriman, Franco Baldelli
BACKGROUND AND AIMS: Elevated serum uric acid (SUA) levels may be associated with endothelial dysfunction. Increased rates of metabolic syndrome (MS) and elevated SUA levels were described in human immunodeficiency virus (HIV) infected patients. We investigated whether SUA levels are associated with endothelial dysfunction in HIV positive patients receiving highly-active antiretroviral therapy (HAART) irrespective of MS. METHODS: In this cross-sectional study of 250 HIV positive patients receiving stable HAART, we evaluated the relationship between MS, SUA levels and endothelial function...
March 17, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29596107/tmc120-displayed-potent-cytotoxic-effect-on-human-cervical-carcinoma-through-enhancing-the-polymerization-of-microtubules
#19
Lili Shi, Le Yu, Desheng Zhong, Chunping Gu, Longyun Lv, Xiaoyun Zeng, Xingang Yao, Lin Li, Shuwen Liu
OBJECTIVE: In the post-HAART era, the incidence of some AIDS-defining cancers declined markedly likely reflecting HAART-related improvements in immunity, whereas incidence of some cancers such as cervical cancer has not been affected. Therefore, it is valuable to find whether antiretroviral drugs or prophylactic microbicides could treat or prevent these cancers, especially the cervical cancer. DESIGN: We screened the anti-HIV drugs, approved or in phase III clinical trials, to identify a potential anticancer drug candidate...
March 28, 2018: AIDS
https://www.readbyqxmd.com/read/29587918/-individualized-comprehensive-therapy-for-the-lung-cancer-patients-with-hiv-infection
#20
Lin Wang, Yanzheng Song
BACKGROUND: To observe clinical features, clinical stagings, types ofpathology, treatment options and clinical effects of patients suffer from HIV infection combined with lung cancer, and also to provide guidance for individualized comprehensive treatment of HIV combined with lung cancer. METHODS: Through the retrospective analysis of 53 cases of HIV merger of lung cancer patients admitted in our department, 47 cases of non-small cell lung cancer (NSCLC), 6 cases of small cell lung cancer (SCLC), 24 cases accepted surgery combined chemotherapy, 22 patients with simple chemotherapy, 7 cases give up treatment; 28 cases are in stages I-III, 25 cases are in stage IV; 24 patients received combined chemotherapy in 28 patients with stages I-III, 2 cases gave up treatment, 2 cases with severe chronic obstructive pulmonary disease (COPD) could not tolerate chemotherapy plus surgery...
April 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
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