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https://www.readbyqxmd.com/read/28534886/a-new-hiv-paradigm-dual-antiretroviral-regimens-as-maintenance-therapy
#1
Vicente Soriano, José M Peña
Since the advent of triple combination antiretroviral therapy in 1996, the prognosis of HIV-infected persons has improved drastically. The clinical benefits of HAART derive from producing sustained viral load suppression and CD4 gains. The major drawbacks of the first HAART regimens were common adverse events and high pill burden, which resulted in difficult drug adherence and led to frequent discontinuations and selection of drug resistance.
May 23, 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28534093/quality-of-life-among-perinatally-hiv-affected-and-hiv-unaffected-school-aged-and-adolescent-ugandan-children-a-multi-dimensional-assessment-of-wellbeing-in-the-post-haart-era
#2
A K Nkwata, S K Zalwango, F N Kizza, J N Sekandi, J Mutanga, M Zhang, P M Musoke, A E Ezeamama
OBJECTIVE: To examine quality of life (QOL) in perinatally HIV-infected (PHIV) or HIV-exposed uninfected (PHEU) vs. healthy HIV-unexposed uninfected (HUU) children during school-age/adolescence. METHODS: PHIV infection was diagnosed via DNA PCR. Current HIV status was confirmed by HIV rapid diagnostic test. Three HIV groups were defined: PHIV, PHEU, and HUU. QOL was assessed with proxy and self-report versions of the PedsQL™ 4.0 instrument at 6-18 years of age...
May 22, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28532195/vertical-mother-to-child-hiv-transmission-in-babies-born-in-a-tertiary-hospital-in-southern-brazil
#3
Manoela Muller Barbieri, Renate von Linsingen, Renato Luiz Sbalqueiro, Edson Gomes Tristão
PURPOSE: Programs for the elimination of mother-to-child transmission of human immunodeficiency virus (HIV) are essentially focused on prevention actions that occur during prenatal care. This study aimed to evaluate the mother-to-child vertical transmission (MCVT) rate, and identify its possible causes, in a sample of pregnant women with HIV. MATERIALS AND METHODS: This was a retrospective and descriptive study. The sample was composed of HIV-positive pregnant women who delivered a live infant in the maternity ward at the hospital of the Federal University of Parana in Brazil, between January 2007 and December 2012...
May 22, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28522794/casual-or-causal-two-unique-cases-of-hodgkin-s-lymphoma-a-case-report-and-literature-review
#4
Faizan Malik, Naveed Ali, Syed Imran Mustafa Jafri, Christian Fidler
BACKGROUND Immunosuppressive diseases and therapies have long been connected to risk of malignancies, especially lymphoma. With some diseases and drugs, the association is well established but the data is mostly anecdotal because of the rarity of the situation. CASE REPORT We present 2 rare cases. The first patient had psoriasis, was on etanercept, and developed Hodgkin's lymphoma. This case is rare because psoriasis and etanercept do not usually cause lymphoma, and if they do, it is predominantly Epstein-Barr virus-positive non-Hodgkin's lymphoma...
May 19, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28521720/the-role-of-il-27-and-its-receptor-in-the-pathogenesis-of-hiv-aids-and-anti-viral-immune-response
#5
Yu-Huang Zheng, Shui-Ling Xiao, Bo He, Yan He, Hua-Ying Zhou, Zi Chen, Mei He, Hong-Yan Wang, Yi-He Lin, Jing Cao
BACKGROUND: Cytokines have been widely demonstrated to involve in the pathogenesis of AIDS and the mechanisms of antiretroviral therapy. Interleukin 27 (IL-27) is a new member of the IL-12 cytokine family and has been shown to interfere HIV-1 virus replication with controversial findings. This study is to investigate the dynamic changes in plasma IL-27 level and cell surface IL-27 receptor expression in HIV/AIDS patients who underwent HAART. METHODS: Whole blood was collected from 34 HIV-positive/AIDS patients 0, 6, and 12 months after initiation of HAART and 27 healthy subjects...
May 17, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28520614/incidence-of-neurological-disorders-among-hiv-infected-individuals-with-universal-health-care-in-taiwan-2000-through-2010
#6
Yi-Tseng Tsai, Yen-Chin Chen, Chen-Yang Hsieh, Wen-Chien Ko, Nai-Ying Ko
OBJECTIVE: To determine the incidence of and factors associated with neurological disorders in a large Taiwanese cohort of HIV-infected persons with free access to highly active antiretroviral therapy (HAART). DESIGN: A retrospective population-based cohort study was conducted using the National Health Insurance Research Database for the years 2000-2010. METHODS: We identified 13,316 HIV-positive persons from 2000 through 2010. We used direct standardization to calculate age- and sex-adjusted incidence rates based on the 2000 World Health Organization world standard population...
May 17, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28518221/micronutrient-supplementation-in-adults-with-hiv-infection
#7
REVIEW
Marianne E Visser, Solange Durao, David Sinclair, James H Irlam, Nandi Siegfried
BACKGROUND: Micronutrient deficiencies are common among adults living with HIV disease, particularly in low-income settings where the diet may be low in essential vitamins and minerals. Some micronutrients play critical roles in maintenance of the immune system, and routine supplementation could therefore be beneficial. This is an update of a Cochrane Review previously published in 2010. OBJECTIVES: To assess whether micronutrient supplements are effective and safe in reducing mortality and HIV-related morbidity of HIV-positive adults (excluding pregnant women)...
May 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28506688/human-immunodeficiency-virus-and-fungal-infections
#8
REVIEW
Jeannette Guarner
The discovery of HIV was largely due to the presence of Pneumocystis pneumonia (PCP) in young patients that did not have the usual known causes of immune deficiencies in the early 1980s. Currently, treatment with highly active anti-retroviral therapy (HAART) and the use of prophylaxis for PCP have lowered the frequency of fungal infections; however, these infections continue to cause morbidity and mortality in those patients that fall out or are not in care. The frequency of specific fungal diseases in HIV patients will depend on the prevalence of fungi in the particular geographic location...
April 8, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28506687/human-immunodeficiency-virus-hiv-and-epstein-barr-virus-ebv-related-lymphomas-pathology-view-point
#9
REVIEW
Ebru Linke-Serinsöz, Falko Fend, Leticia Quintanilla-Martinez
The contribution of Epstein Barr virus (EBV) and Kaposi sarcoma herpes virus (KSHV) to the development of specific types of malignant lymphomas occurring in the human immunodeficiency virus (HIV) setting has been extensively studied since the beginning of the HIV epidemic 35 years ago. The introduction of highly active antiretroviral therapies (HAART) in 1996 has changed dramatically the incidence of HIV-related malignancies. Nevertheless, malignant lymphomas continue to be the major group of malignances observed in HIV infected individuals, and the most common cause of cancer related-deaths...
April 7, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28506307/intestinal-parasitic-infections-and-its-association-with-undernutrition-and-cd4-t-cell-levels-among-hiv-aids-patients-on-haart-in-butajira-ethiopia
#10
Dereje Gedle, Gemechu Kumera, Tewodros Eshete, Kasahun Ketema, Haweni Adugna, Fetuma Feyera
BACKGROUND: Intestinal parasitic infections and HIV/AIDS have been the major public health problems and remain a vital cause of morbidity and mortality in developing countries. Both problems are linked in a vicious cycle. The magnitude of intestinal parasites was prevalent among people living with HIV/AIDS even in the HAART era. However, the pertinent risk factors associated with intestinal parasites among HIV/AIDS patients were not well investigated in Ethiopia particularly at Butajira town...
May 15, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/28506154/seroadaptive-strategies-of-vancouver-gay-and-bisexual-men-in-a-treatment-as-prevention-environment
#11
Eric Abella Roth, Zishan Cui, Ashleigh Rich, Nathan Lachowsky, Paul Sereda, Kiffer Card, Jody Jollimore, Terry Howard, Heather Armstrong, David Moore, Robert Hogg
British Columbia's Treatment as Prevention policy has provided free access to Highly Active Antiretroviral Therapy (HAART) to all HIV-positive provincial residents since 1996. One outcome is an increase in HIV-positive gay and bisexual men (GBM) with suppressed viral loads. Previous cross-sectional analyses indicated that some Vancouver GBM now recognize condomless anal sex with men on HAART who report a suppressed viral load as a sero-adaptive strategy. To test the hypothesis that this new strategy, termed viral load sorting (VLS), is recognized and used among by GBM in the Momentum Health Study, we analyzed longitudinal data for HIV-negative/unknown (n = 556) and HIV-positive (n = 218) sero-status participants...
May 16, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28492779/prevalence-of-kaposi-s-sarcoma-in-patients-with-aids-and-associated-factors-s%C3%A3-o-paulo-sp-brazil-2003-2010
#12
Mariza Vono Tancredi, Valdir Monteiro Pinto, Mariliza Henrique da Silva, Sidnei Rana Pimentel, Tatiana Santana Bueno da Silva, Sandra Mitie Akamatsu Ito, Jonathan E Golub, Ana Luiza de Castro Conde Toscano
OBJECTIVE: to estimate the prevalence of Kaposi's sarcoma (KS) in patients with AIDS and identify the associated factors to the occurrence of this neoplasm. METHODS: this is a cross-sectional study with notification data from two AIDS reference centers in São Paulo-SP, Brazil, from January, 2003 to March, 2010; probabilistic linkage and multiple logistic regression methods were applied. RESULTS: among 3,557 AIDS cases, 213 (6%) presented KS; 95...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28491869/prevalence-and-associated-factors-of-suicidal-ideation-and-attempt-among-people-living-with-hiv-aids-at-zewditu-memorial-hospital-addis-ababa-ethiopia-a-cross-sectional-study
#13
Etsay Hailu Gebremariam, Mebratu Mitiku Reta, Zebiba Nasir, Fisseha Zewdu Amdie
Background. Human Immune Deficiency Virus (HIV/AIDS) continues to be an underrecognized risk for suicidal ideation, suicidal attempt, and completion of suicide. Suicidal ideation and attempt in HIV/AIDS is not only a predictor of future attempted suicide and completed suicide. Methods. An institution based cross-sectional study was conducted among HIV-positive patients attending HIV care at Zewditu Memorial Hospital. Systematic random sampling technique was used to recruit 423 participants from April to May 2014...
2017: Psychiatry Journal
https://www.readbyqxmd.com/read/28489843/-non-cirrhotic-portal-hypertension-due-to-didanosina-a-rare-case
#14
María T Gamero, María Susana Gallardo, Víctor Aguilar, Eduar Bravo, Julissa Guevara, Fernando Mejia
Liver involvement is usually seen in patients infected with the human immunodeficiency virus (HIV), especially in patients coinfected with hepatitis B or C, in alcohol abuse, etc. However, there is a group of patients who develop liver involvement and portal hypertension of unspecified cause. Non-cirrhotic portal hypertension (NCPH) is a liver disorder recently described, but potentially serious. It has been reported in HIV-infected patients with highly active antiretroviral therapy (HAART), specifically didanosine (DDI)...
January 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28489061/microbial-natural-product-alternariol-5-o-methyl-ether-inhibits-hiv-1-integration-by-blocking-nuclear-import-of-the-pre-integration-complex
#15
Jiwei Ding, Jianyuan Zhao, Zhijun Yang, Ling Ma, Zeyun Mi, Yanbing Wu, Jiamei Guo, Jinmin Zhou, Xiaoyu Li, Ying Guo, Zonggen Peng, Tao Wei, Haisheng Yu, Liguo Zhang, Mei Ge, Shan Cen
While Highly Active Antiretroviral Therapy (HAART) has significantly decreased the mortality of human immunodeficiency virus (HIV)-infected patients, emerging drug resistance to approved HIV-1 integrase inhibitors highlights the need to develop new antivirals with novel mechanisms of action. In this study, we screened a library of microbial natural compounds from endophytic fungus Colletotrichum sp. and identified alternariol 5-O-methyl ether (AME) as a compound that inhibits HIV-1 pre-integration steps. Time-of addition analysis, quantitative real-time PCR, confocal microscopy, and WT viral replication assay were used to elucidate the mechanism...
May 10, 2017: Viruses
https://www.readbyqxmd.com/read/28486060/aerobic-fitness-and-moderate-to-vigorous-physical-activity-in-children-and-adolescents-living-with-hiv
#16
Luiz Rodrigo Augustemak de Lima, Diego Augusto Santos Silva, Kelly Samara da Silva, Andreia Pelegrini, Isabela de Carlos Back, Edio Luiz Petroski
AIMS: To examine aerobic fitness, total moderate to vigorous physical activity (MVPA) and also patterns in terms of MVPA between children and adolescents with human immunodeficiency virus (HIV) and controls, and to determine whether differences, if any, are associated with HIV, sex and highly active antiretroviral therapy (HAART). METHODS: A cross-sectional analysis was carried out with 130 children and adolescents, aged between 8 and 15 years, divided into two groups (HIV group= 65 patients, control group= 65 healthy participants)...
May 9, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28477349/cytological-and-cytomorphometric-evaluation-of-the-oral-mucosa-in-hiv-infected-patients-undergoing-antiretroviral-therapy
#17
Mônica Ghislaine Oliveira Alves, Celina Faig Lima Carta, Adriana Aigotti Haberbeck Brandão, Juvencio José Duailibe Furtado, Marcelo Marcucci, Janete Dias Almeida
BACKGROUND: To evaluate HIV infection-induced alterations in the oral mucosa by comparing inflammation, cell maturation and cytomorphometric changes in oral mucosal cells between HIV-infected patients undergoing highly active antiretroviral therapy (HAART) and non-HIV-infected patients. \ METHODS: Thirty HIV-infected patients undergoing HAART and 30 non-HIV-infected patients were studied. Four smears were obtained from the lateral border of the tongue and floor of the mouth with a cytobrush...
May 6, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28474549/haart-in-hiv-aids-treatments-future-trends
#18
Da Yong Lu, Nagendra Sastry Yarla, Bin Xu, Jian Ding, Ting-Ren Lu, Hong Ying Wu
AIDS (acquired immune deficient syndrome) is a deadly human viral infectious disease caused by HIV (human immune-deficient virus) infection. Almost every AIDS patient losses his/her life before mid 1990s. AIDS was once the 1st disease killer in US (1993). After one decade hard work, antiviral drug cocktails-high active anti-retroviral therapy (HAART) have been invented for almost all HIV infection treatments. Due to the invention of HAART, 80-90% HIV/AIDS patients still effectively response to HAART for deadly AIDS episode controls and life saving...
May 5, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28471983/hospitalizations-of-hiv-patients-in-a-major-israeli-hiv-aids-center-during-the-years-2000-to-2012
#19
Keren Mahlab-Guri, Ilan Asher, Shira Bezalel-Rosenberg, Daniel Elbirt, Zev M Sthoeger
To evaluate hospitalization rates and causes among human immunodeficiency virus (HIV) patients in the late highly active antiretroviral therapy (HAART) era. Data during the years 2000 to 2012 were obtained from hospital/clinical charts. Hospitalizations were defined as a ≥24 hours hospital admission. Obstetric admissions were excluded. Causes of hospitalizations were defined as acquired immune deficiency syndrome (AIDS)-defining illnesses, AIDS-related diseases (HAART adverse events, metabolic complications and non-AIDS-defining tumors/infections), and non-HIV-related diseases...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28466817/dynamic-observation-of-il-33-and-its-receptors-in-hiv-patients-who-received-haart
#20
B He, L Zheng, H Zhou, Y He, Z Chen, S Xiao, H Wang, Y Ling, Y Zheng
The purpose of this study was to observe the changes in serum IL-33 and its soluble receptors, serum sST2 level and ST2L expression in PBMCs of HIV-infected patients receiving highly-active antiretroviral therapy (HAART) for 12 monthes. Fifty-five chronic HIV-1-infected adults were recruited for this study before initiation of HAART. 30 age and gender matched healthy adults were recruited as control. Blood was obtained from each patient at baseline (0 month) and 12 months after initiation of highly active antiretroviral therapy(HAART), and each healthy person...
March 31, 2017: Cellular and Molecular Biology
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