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https://www.readbyqxmd.com/read/29241911/a-comparison-of-mean-corpuscular-volume-mcv-between-thalassemia-carrier-and-non-thalassemia-carrier-pregnant-women-receiving-highly-active-antiretroviral-therapy-haart
#1
Yada Thongyou, Fuanglada Tongprasert
OBJECTIVE: HIV-infected treatment with antiretroviral drugs is one of the common causes of macrocytosis. In patients receiving highly active antiretroviral therapy (HAART), the mean corpuscular volume (MCV) can be shifted from microcytic to normocytic or macrocytic after treatment and significantly affected the thalassemia screening. This study aimed to compare MCV between thalassemia-carrier and non-thalassemia-carrier antiretroviral drug-naïve, HIV-infected, pregnant women receiving HAART...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29230854/adjuvant-potential-of-virgin-coconut-oil-extract-on-antiretroviral-therapy-induced-testicular-toxicity-an-ultrastructural-study
#2
O O Ogedengbe, A I Jegede, I O Onanuga, U Offor, A I Peter, E N Akang, E C S Naidu, O O Azu
The effects of Virgin coconut oil as an adjuvant to highly active antiretroviral therapy (HAART) were investigated on the testicular ultrastructure and biochemical markers in rats. Twenty male Sprague-Dawley rats, weighing 153-169 g were divided into four groups and treated as follows: control A (distilled water), B (HAART), C (HAART+Virgin coconut oil 10 ml/kg) and D (Virgin coconut oil [VCO] 10 ml/kg). Testicular segments were evaluated using transmission electron microscopy. Serum was assayed for testosterone, luteinising hormone, follicle stimulating hormone and testicular tissue for malondialdehyde and glutathione...
December 12, 2017: Andrologia
https://www.readbyqxmd.com/read/29224754/prevalence-of-chronic-ear-disease-among-hiv-children-in-sub-saharan-africa
#3
David C Ianacone, Alden F Smith, Margaretha L Casselbrant, Robbert J H Ensink, Farrel Buchinsky, Abebe Melaku, Glenn Isaacson
OBJECTIVES: To determine the prevalence of chronic ear disease in HIV+, highly active anti-retroviral therapy (HAART)-treated children and compare this to the prevalence in healthy children of similar age living in a similar setting. INTRODUCTION: From previous clinical work in Ethiopia, we suspected that chronic middle ear disease was common both in the general pediatric population and especially among children with HIV/AIDS. Few studies have examined the prevalence of chronic ear disease in HIV + children, particularly in those treated with HAART...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29214077/mortality-and-its-predictors-among-hiv-infected-patients-taking-antiretroviral-treatment-in-ethiopia-a-systematic-review
#4
REVIEW
Mohammed Biset Ayalew
Background: Even though the benefit of antiretroviral therapy (ART) is well established, there is a regional variation in the extent of its benefit. The aim of this review is to highlight mortality and its predictors in Ethiopian adult HIV patients who were on ART. Methods: Relevant articles were searched on PubMed and Google Scholar databases. The search terms used in different combinations were predictor/determinant/factors, mortality/death/survival, HIV, ART/HAART, and Ethiopia...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/29211183/survival-of-patients-with-aids-and-co-infection-with-the-tuberculosis-bacillus-in-the-south-and-southeast-regions-of-brazil
#5
Márcio Cristiano de Melo, Maria Rita Donalisio, Ricardo Carlos Cordeiro
The study investigates the survival of patients with co-infection AIDS-TB through a retrospective study of a cohort of individuals aged 13 or more and the diagnosis of AIDS reported in the years 1998-99 and following 10 years. Of the 2,091 AIDS cases, 517 (24.7%) had positive diagnosis for tuberculosis, and 379 (73.3%) were male. The risk among co-infected patients was 1,65 times the not co-infected. Have been compared the exposed and non-exposed through the Kaplan-Meier and Cox method. The variables associated with longer survival were: female gender (HR = 0...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29208455/high-prevalence-and-incidence-of-hpv-related-anal-cancer-precursor-lesions-in-hiv-positive-women-in-the-late-haart-era
#6
Carmen Hidalgo-Tenorio, Samantha E de Jesus, Javier Esquivias, Juan Pasquau
INTRODUCTION: Anal cancer is one of the most common non-AIDS defining malignancies, especially in men who have sex with men and women living with HIV (WLHIV). OBJECTIVES: To evaluate the prevalence and incidence of precursor lesions (high-grade squamous intraepithelial lesions [HSIL]) and anal cancer in our cohort of women and to compare them to cervical lesions; to calculate the percentage of patients that acquire and clear oncogenic genotypes (HR-HPV) in the anal canal; and to determine predictive factors for anal HPV infection...
December 2, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29207194/quercetin-synergistically-reactivates-human-immunodeficiency-virus-type-1-latency-by-activating-nuclear-factor%C3%A2-%C3%AE%C2%BAb
#7
Xinyi Yang, Xiaoli Zhu, Haiyan Ji, Junxiao Deng, Panpan Lu, Zhengtao Jiang, Xian Li, Yibo Wang, Chuqiao Wang, Jingya Zhao, Yanan Wang, Yangcheng Zhong, He Yang, Huanzhang Zhu
Highly active antiretroviral therapy (HAART) is very effective in suppressing human immunodeficiency virus type 1 (HIV‑1) replication. However, the treatment is required to be administered for the remainder of an individual's lifetime due to latent HIV‑1 reservoirs. The 'shock‑and‑kill' strategy, which involves using agents to reactivate latent HIV‑1 and subsequently killing latently infected cells in the presence of HAART, was recently proposed. Unfortunately, no agents have currently demonstrated an ability to reactivate latent HIV‑1 in vivo in the absence of toxicity...
November 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29181032/overt-lower-gastrointestinal-bleeding-and-pseudotumor-a-rare-presentation-of-cytomegalovirus-infection
#8
Akanksha Agrawal, Deepanshu Jain, Sameer Siddique
Cytomegalovirus (CMV) is a ubiquitous organism which can infect multiple organs of the body. In an immunocompromised patient, it can have a myriad of gastrointestinal manifestations. We report a case of recurrent hematochezia and concomitant pseudotumor in an AIDS (acquired immunodeficiency syndrome) patient attributable to CMV infection. A 62-year-old man with a history of AIDS, noncompliant with highly active antiretroviral therapy (HAART), presented with bright red blood per rectum. Index colonoscopy showed presence of multiple ulcers, colonic stenosis, and mass-like appearing lesion...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/29177382/-high-frequency-of-dyslipidemia-in-vih-infected-patients-in-aa-peruvian-public-hospital
#9
Paola L Rondan, Oscar Flores-Flores, Nicole A Doria, Gustavo Valencia-Mesias, Víctor Chávez-Pérez, Jaime Soria
The objective of the study was to determine the frequency and characteristics of dyslipidemia in patients with HIV in highly active antiretroviral therapy (HAART) in a Peruvian public hospital. A cross-sectional study was carried out in patients with complete lipid profile after receiving at least six months of HAART. Dyslipidemia was defined according to the criteria of the NCEP-ATP III. We reviewed 2 975 clinical histories, and included 538 (18.1%) in the analysis. The frequency of dyslipidemia was 74.7%...
April 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29173177/integrase-strand-transfer-inhibitors-and-the-emergence-of-immune-reconstitution-inflammatory-syndrome-iris
#10
Mina Psichogiou, Dimitrios Basoulis, Maria Tsikala-Vafea, Stefanos Vlachos, Christos J Kapelios, Georgios L Daikos
BACKGROUND: Immune reconstitution inflammatory syndrome (IRIS) is a major concern when starting highly active anti-retroviral therapy (HAART) in new patients and especially late presenters. This study attempts to identify risk factors for IRIS and investigate whether certain treatment regimens increase the probability of IRIS for patients at risk. METHODS: Retrospective single-centre study of HIV patients treated with HAART. RESULTS: A total of 417 patients were included...
November 22, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29165512/-antiretroviral-treatment-adherence-for-hiv-aids-in-women-a-sociocultural-perspective
#11
Julieta Belmar, Valeria Stuardo
BACKGROUND: Adequate adherence to HAART has a high impact on survival of AIDA patients. There is little consensus on the causes of low adherence to treatment in women, who are in a situation of inequality in terms of prevention and related care. OBJECTIVES: To explore and describe the socio-cultural aspects related to the adherence of women to antiretroviral treatment for HIV / AIDS. MATERIAL AND METHODS: Qualitative, exploratory-descriptive study...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29165511/-cystoisospora-belli-infection-in-hiv-patients-analysis-of-cases-with-different-clinical-evolution
#12
Heber Silva-Díaz, Darwin Fernández-Valverde, Gustavo Hernández-Córdova, Virgilio E Failoc-Rojas
INTRODUCTION: Cystoisospora belli infection is one of the most important causes of watery diarrhea in patients with HIV and causes high rates of morbidity and mortality. METHODS: A retrospective study was conducted in patients with HIV and diarrhea by C. belli. Clinical and laboratory characteristics were collected by analyzing clinical records. RESULTS: Four had recurrent diarrhea despite receiving secondary prophylaxis with cotrimoxazole and specific treatment, two of which had a good viral and immunological response to highly active antiretroviral therapy (HAART) at the time of diagnosis and antiparasitic treatment...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29160443/body-fat-redistribution-and-changes-in-lipid-and-glucose-metabolism-in-people-living-with-hiv-aids
#13
Rebeca Antunes Beraldo, André Pereira Dos Santos, Mariana Palma Guimarães, Helena Siqueira Vassimon, Francisco José Albuquerque de Paula, Dalmo Roberto Lopes Machado, Maria Cristina Foss-Freitas, Anderson Marliere Navarro
INTRODUCTION: The HIV lipodystrophy syndrome is characterized by changes in metabolism, and body composition that increase cardiovascular risk of people living with HIV/AIDS (PLWHA) using highly active antiretroviral therapy (HAART). OBJECTIVE: To assess the prevalence of lipodystrophy and changes in lipid and glucose metabolism in PLWHA in use of HAART. METHODS: For the anthropometric evaluation we measured weight, height and abdominal circumference (AC)...
July 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/29159260/public-health-approach-to-prevent-cervical-cancer-in-hiv-infected-women-in-kenya-issues-to-consider-in-the-design-of-prevention-programs
#14
REVIEW
Sonia Menon, Rodolfo Rossi, Stacy G Harmon, Hillary Mabeya, Steven Callens
Women living with HIV in Africa are at increased risk to be co-infected with Human Papilloma Virus (HPV), persistent high risk (HR) HPV infection and bacterial vaginosis (BV), which compounds HPV persistence, thereby increasing the risk for cervical dysplasia. New guidance from WHO in 2014 advocating for a "screen and treat" approach in resource poor settings is becoming a more widely recommended screening tool for cervical cancer prevention programs in such contexts. This review article summarizes the risk factors to be considered when designing a primary and secondary cervical prevention program in a post-vaccination era for HIV-infected women in Kenya...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29158917/lipodystrophy-among-hiv-infected-patients-attending-care-and-treatment-clinics-in-dar-es-salaam
#15
Marina Njelekela, Rose Mpembeni, Alfa Muhihi, Nzovu Ulenga, Eric Aris, Deodatus Kakoko
Background: HIV infection and long-term HAART use are associated with metabolic and morphological changes. We assessed prevalence, types, and risk factors associated with lipodystrophy among HIV-infected adults attending CTC in Dar es Salaam, Tanzania. Methods: Analysis included 466 HIV-infected patients. Study protocol involved administration of structured questionnaire to collect sociodemographic and clinical information. Diagnosis of lipodystrophy was based on physician clinical assessment...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/29156062/surgical-technique-for-pulled-in-two-syndrome-three-cases-with-chronic-progressive-external-ophthalmoplegia
#16
Alexander Matthew Jones, Julia Starte, Hamish Dunn, Kate Ahmad, Kimberley Tan
The authors describe three examples of "pulled in two syndrome" (PITS) from a series of 13 patients undergoing strabismus surgery with underlying chronic progressive external ophthalmoplegia (CPEO) and illustrate techniques for recovery of the "pulled in two" extraocular muscle should the complication arise. In all cases, a rectus muscle snapped under minimal tension while held on a strabismus hook during strabismus surgery. Two patients suffered from CPEO as a result of genetic mitochondrial disease, whereas one resulted from presumed mitochondrial toxicity induced by HAART...
November 17, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29135386/timing-of-diagnosis-understanding-resilience-narratives-of-hiv-positive-older-adults-diagnosed-pre-and-post-haart
#17
Lesley M Harris, Charles A Emlet, Christina Pierpaoli Parker, Charles Furlotte
BACKGROUND: Despite the growing population of older adults living with HIV/AIDS, few studies have examined this population in terms of timing of HIV diagnosis. This study explores resilience and protective factors among HIV-positive older adults, 17 of whom were diagnosed prior to the development of highly active antiretroviral therapy (HAART), and 13 of whom were diagnosed after the development HAART. METHODS: We explored the concepts of resilience and protective factors in 30 older adults living with HIV in Ontario, Canada...
November 14, 2017: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/29122683/high-cxcl10-ip-10-levels-are-a-hallmark-in-the-clinical-evolution-of-the-hiv-infection
#18
Jacqueline María Valverde-Villegas, Rúbia Marília de Medeiros, Joel Henrique Ellwanger, Breno Riegel Santos, Marineide Gonçalves de Melo, Sabrina Esteves de Matos Almeida, José Artur Bogo Chies
The aim of this study was to investigate the modulation of plasma CXCL10, CCL20, CCL22, CCL2, CCL17 and CCL24 levels in HIV-positive patients grouped according to extreme phenotypes of progression to AIDS, and at different stages of HIV infection. HIV-positive individuals with extreme phenotypes of AIDS progression (n=58) at different clinical stages (chronic individuals, both pre-HAART and under-HAART) and HIV-negative controls (n=20) were evaluated. Additionally, HIV-positive individuals that initiated HAART with >350CD4(+)T-cells/mm(3) were compared with those who initiated treatment with <350CD4(+)T-cells/mm(3)...
November 6, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29097650/leiomyosarcoma-of-the-inferior-vena-cava-in-an-hiv-positive-adult-patient-a-case-report-and-review-of-the-literature
#19
Jing Xu, Arash Velayati, Barbara J Berger, Ming Liu, Naga K Sucharita Cheedella, Vladimir Gotlieb
BACKGROUND Leiomyosarcoma is the most common primary malignancy of the inferior vena cava (IVC), and represents approximately 10% of primary retroperitoneal sarcomas. Leiomyosarcoma presents with non-specific symptoms, including abdominal pain or back pain. There is an increased incidence in immunosuppressed individuals. CASE REPORT An unusual presentation of IVC leiomyosarcoma is reported in a 46-year-old female patient infected with human immunodeficiency virus (HIV) who was on highly active antiretroviral therapy (HAART) and who had a normal CD4 count of 934, who presented with back pain...
November 3, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29095139/parvovirus-b19-in-hiv-adult-patients-with-different-cd4-lymphocyte-counts
#20
Mauro Sebastian Pedranti, Gonzalo Rodriguez-Lombardi, Romina Bracciaforte, Natalia Romano, Pablo Lujan, Brenda Ricchi, Jorge Mautino, Maria Pilar Adamo
PURPOSE: Human parvovirus B19 (B19V) can cause anemia in immunocompromised patients. We aimed to investigate the presence of B19V in HIV+ adults with different CD4+ T cell counts, to recognise the frequency of B19V in these different conditions and its possible association with anemia. METHODOLOGY: We studied B19V specific IgM, IgG and DNA in 98 HIV+ patients and in 52 healthy individuals. HIV load, CD4+ counts and haemoglobin level were also determined in the patients...
November 2, 2017: Journal of Medical Microbiology
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