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https://www.readbyqxmd.com/read/28231661/-a-retrospective-cohort-study-on-survival-status-of-aids-patients-among-15-or-above-year-olds-in-henan-province-from-2008-to-2015
#1
W J Yang, N Li, Y Liang, J Li, P Y Fan, D Y Sun, Q Zhu, Z Wang
Objective: To explore the survival status and affecting factors among patients diagnosed as AIDS, in Henan province. Methods: Database of AIDS patients were downloaded from the China information system for disease prevention and control-AIDS with a retrospective study conducted. Inclusion criteria on patients would involve those diagnosed between 2008 and 2015, aged 15 years or above. Results: A total number of 25 525 HIV/AIDS patients were enrolled in this study. During the follow-up period, the overall mortality among all the patients was 24...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28224137/hmgb1-anti-hmgb1-antibodies-define-a-molecular-signature-of-early-stages-of-hiv-associated-neurocognitive-isorders-hand
#2
Marie-Lise Gougeon, Béatrice Poirier-Beaudouin, Jacques Durant, Christine Lebrun-Frenay, Héla Saïdi, Valérie Seffer, Michel Ticchioni, Stephane Chanalet, Helene Carsenti, Alexandra Harvey-Langton, Muriel Laffon, Jacqueline Cottalorda, Christian Pradier, Pierre Dellamonica, Matteo Vassallo
BACKGROUND: HIV-associated neurocognitive disorders (HAND) persist in the post-HAART era, characterized by asymptomatic neurocognitive impairment (ANI) and mild neurocognitive disorders (MND). High mobility group box 1 (HMGB1) is a non-histone chromosomal protein widely expressed in the nucleus of all eukaryotic cells, including brain cells, which acts as a potent proinflammatory cytokine when actively secreted from immune cells. Recent reports suggested that HMGB1 acts on microglial cells to promote neuroinflammation...
February 2017: Heliyon
https://www.readbyqxmd.com/read/28224132/dataset-of-longitudinal-analysis-of-tear-cytokine-levels-cd4-cd8-counts-and-hiv-viral-load-in-dry-eye-patients-with-hiv-infection
#3
Praveen Kumar Balne, Rupesh Agrawal, Veonice Bijin Au, Bernett Lee, Eileen Loo, Louis Tong, Arkasubhra Ghosh, Stephen C Teoh, John Connolly, Petrina Tan
The data presented in this article shows the longitudinal analysis of tear fluid cytokine profiles, blood CD4 and CD8 counts and HIV viral load in 34 dry eye patients with HIV infection during the HAART therapy. Clinical samples were collected from HIV patients with dry eye disease at the time of presentation to the clinic (visit 1), three months (visit 2) and 6 months (visit 3) after the presentation. At each time point tear samples were evaluated for 41 cytokines using Luminex bead based multiplex assay and blood samples were tested for HIV viral load and CD4 and CD8 counts...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28220718/the-big-imitator-strikes-again-a-case-report-of-neurosyphilis-in-a-patient-with-newly-diagnosed-hiv
#4
Sévérine de Bruijn, Chris Kenyon, Nicolas Léonard, Erika Vlieghe
BACKGROUND: Neurosyphilis is the result of an infection of the central nervous system caused by the spirochete Treponema pallidum. Its clinical presentation includes meningovascular syphilis, tabes dorsalis, and dementia paralytica, resulting in a wide range of symptoms such as psychosis, Parkinsonism, and depression. CASE REPORT: A 49-year-old male was admitted to a psychiatric hospital because of social withdrawal and self-neglect, indicative of a major depression...
February 21, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28216610/pulmonary-kaposi-sarcoma-with-osseous-metastases-in-an-human-immunodeficiency-virus-hiv-patient-a-remarkable-response-to-highly-active-antiretroviral-therapy
#5
Ahmed Dirweesh, Muhammad Yasir Khan, Shaikh Fawad Hamiz, Nigahus Karabulut
BACKGROUND Kaposi sarcoma (KS) is known to involve the mucocutaneous tissues and the aero-digestive tracts. In acquired immune deficiency syndrome (AIDS) patients, KS has an aggressive course and carries poor prognosis. We present a case of pulmonary KS with osseous metastases as the first presentation of human immunodeficiency virus (HIV) infection in a young male. The lesions impressively decreased in size and numbers following initiation of highly active antiretroviral therapy (HAART). CASE REPORT A 34-year-old heterosexual male presented with a one month history of cough and 15-20 pound weight loss within six months...
February 20, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28212619/brain-and-liver-pathology-amyloid-deposition-and-interferon-responses-among-older-hiv-positive-patients-in-the-late-haart-era
#6
Isaac H Solomon, Umberto De Girolami, Sukrutha Chettimada, Vikas Misra, Elyse J Singer, Dana Gabuzda
BACKGROUND: HIV+ patients on highly active antiretroviral therapy (HAART) with suppressed viral loads have a low incidence of HIV-associated dementia, but increased prevalence of milder forms of HIV-associated neurocognitive disorders (HAND). These milder forms of HAND are often associated with minimal histological abnormalities, and their pathophysiology is unclear. Comorbidities, altered amyloid metabolism, accelerated brain aging, and activated interferon responses are suspected to play a role in HAND pathogenesis in HAART-treated persons...
February 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28209492/reproductive-considerations-in-the-setting-of-chronic-viral-illness
#7
REVIEW
Brent M Hanson, Jessie A Dorais
Special considerations must be taken when patients with human immunodeficiency virus (HIV), Hepatitis B, or Hepatitis C desire to achieve pregnancy. Patients with chronic viral illnesses desire children at rates similar to the general population, and options are available to decrease both vertical transmission and viral transmission between partners. Preconception counseling or consultation with fertility specialists is imperative in patients with HIV, Hepatitis B, and Hepatitis C so that reproductive goals can be addressed and optimized...
February 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28198390/hiv-cause-specific-deaths-mortality-risk-factors-and-the-combined-influence-of-haart-and-late-diagnosis-in-zhejiang-china-2006-2013
#8
Lin Chen, Xiaohong Pan, Qiaoqin Ma, Jiezhe Yang, Yun Xu, Jinlei Zheng, Hui Wang, Xin Zhou, Tingting Jiang, Jun Jiang, Lin He, Jianmin Jiang
To examine patterns of human immunodeficiency virus (HIV) cause-specific deaths, risk factors, and the effect of interactions on mortality, we conducted a retrospective cohort study in Zhejiang, China, from 2006 to 2013. All data were downloaded from the acquired immune deficiency syndrome (AIDS) Prevention and Control Information System. The Cox proportional hazards model was used to assess predictors of cause-specific death. The relative excess risk due to interaction and ratio of hazard ratios (RHR) were calculated for correlations between HAART, late diagnosis, and age...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28198350/cerebrospinal-fluid-viral-load-and-neopterin-in-hiv-positive-patients-with-undetectable-viraemia
#9
Ilaria Motta, Tiziano Allice, Alessandra Romito, Micol Ferrara, Sara Ecclesia, Daniele Imperiale, Valeria Ghisetti, Giovanni Di Perri, Stefano Bonora, Andrea Calcagno
BACKGROUND: Cerebrospinal fluid (CSF) HIV RNA is commonly used as a marker of compartmental antiviral activity in HIV-positive patients. Undetectable CSF HIV RNA levels have been associated with low CSF neopterin levels and better neurocognitive performances. Aim of this study was to analyse the prevalence and predictors of non-detectable CSF HIV RNA using a commercial assay. METHODS: In adult HIV-positive HAART-treated patients with confirmed plasma HIV RNA <50 copies/mL, CSF HIV RNA (with Roche Amplicor Assay) and neopterin were measured...
February 15, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28196510/partial-hiv-c2v3-envelope-sequence-analysis-reveals-association-of-coreceptor-tropism-envelope-glycosylation-and-viral-genotypic-variability-among-kenyan-patients-on-haart
#10
Rose C Kitawi, Carol W Hunja, Rashid Aman, Bernhards R Ogutu, Anne W T Muigai, Gilbert O Kokwaro, Washingtone Ochieng
BACKGROUND: HIV-1 is highly variable genetically and at protein level, a property it uses to subvert antiviral immunity and treatment. The aim of this study was to assess if HIV subtype differences were associated with variations in glycosylation patterns and co-receptor tropism among HAART patients experiencing different virologic treatment outcomes. METHODS: A total of 118 HIV env C2V3 sequence isolates generated previously from 59 Kenyan patients receiving highly active antiretroviral therapy (HAART) were examined for tropism and glycosylation patterns...
February 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/28192480/mtor-activity-in-aids-related-diffuse-large-b-cell-lymphoma
#11
Sara H Browne, Julio A Diaz-Perez, Michael Preziosi, Charles C King, George A Jones, Sonia Jain, Xiaoying Sun, Erin G Reid, Scott VandenBerg, Huan-You Wang
BACKGROUND: Patients infected with HIV have a significantly increased risk of developing non-Hodgkin lymphomas despite the widespread use of HAART. To investigate mTOR pathway activity in acquired immunodeficiency syndrome (AIDS) related diffuse large B-cell lymphoma AR-DLBCL, we used immunohistochemistry to examine the presence of the phosphorylated 70 ribosomal S6 protein-kinase (p70S6K), an extensively studied effector of mTOR Complex 1 (mTORC1) and the phosphorylated phosphatase and tensin homolog (pPTEN), a negative regulator of mTORC1 pathway...
2017: PloS One
https://www.readbyqxmd.com/read/28181688/dental-implants-and-bone-augmentation-in-hiv-infected-patients-under-haart-case-report-and-review-of-the-literature
#12
Fábio Vidal, Rafael Vidal, Jeter Bochnia, Rodrigo Carvalho de Souza, Lucio Souza Gonçalves
The present study reviewed the literature regarding dental implants in HIV-infected patients and reports the long-term follow-up of three clinical cases of patients under HAART that received bone augmentation and dental implants. The first case presents a young patient with a large defect in the mandible, as a consequence of a longitudinal fracture, that was treated with guided bone regeneration (GBR) previously to implant placement. The second case reported is middle-aged man with a fractured upper lateral incisor treated with immediate placement and simultaneous GBR to repair the dehiscence due to the buccal bone resorption...
February 9, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/28178892/trends-in-the-incidence-of-aids-defining-and-non-aids-defining-cancers-in-people-living-with-aids-a-population-based-study-from-s%C3%A3-o-paulo-brazil
#13
Luana F Tanaka, Maria do Rosário DO Latorre, Eliana B Gutierrez, Christian Heumann, Karl-Heinz Herbinger, Guenter Froeschl
People living with AIDS are at increased risk of developing certain cancers. Since the introduction of the highly active antiretroviral therapy (HAART), the incidence of AIDS-defining cancers (ADCs) has decreased in high-income countries. The objective of this study was to analyse trends in ADCs and non-AIDS-defining cancers (NADCs) in HIV-positive people with a diagnosis of AIDS, in comparison to the general population, in São Paulo, Brazil. A probabilistic record linkage between the 'Population-based Cancer Registry of São Paulo' and the AIDS notification database (SINAN) was conducted...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28164754/prevalence-of-adverse-drug-reactions-to-highly-active-antiretroviral-therapy-haart-among-hiv-positive-patients-in-imam-khomeini-hospital-of-tehran-iran
#14
Raheleh Golrokhy, Hamid Emadi Koochak, Azita Babaii, Alia Pourdast, Mehrnaz Rasoolinejad, Saeed Reza Jamali Moghadam, Reza Rezaei Taheri, Seyed Ahmad SeyedAlinaghi
OBJECTIVE: The present study assessed the prevalence of adverse drug reactions (ADRs) among HIV positive patients referred to Imam Khomeini hospital in Tehran, Iran. METHODS: This is a cross sectional study regarding side effects of Highly Active Antiretroviral Therapy (HAART) in HIV positive patients referred to Voluntary Counseling and Testing (VCT) center in Imam Khomeini Hospital of Tehran, Iran during a period of the year 2009 to 2010. Two hundred patients under antiretroviral treatment evaluated for the side effects of drug based on available records, face to face interviews and written lab data...
January 17, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28158991/peritonitis-outcomes-in-patients-with-hiv-and-end-stage-renal-failure-on-peritoneal-dialysis-a-prospective-cohort-study
#15
Kwazi C Z Ndlovu, Wilbert Sibanda, Alain Assounga
BACKGROUND: Few studies have investigated the management of human immunodeficiency virus (HIV)-associated end-stage renal failure particularly in low-resource settings with limited access to renal replacement therapy. We aimed to evaluate the effects of HIV infection on continuous ambulatory peritoneal dialysis (CAPD)-associated peritonitis outcomes and technique failure in highly active antiretroviral therapy (HAART)-treated HIV-positive CAPD populations. METHODS: We conducted a single-center prospective cohort study of consecutive incident CAPD patients recruited from two hospitals in Durban, South Africa from September 2012-February 2015...
February 3, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28155724/structural-analyses-of-2015-updated-drug-resistant-mutations-in-hiv-1-protease-an-implication-of-protease-inhibitor-cross-resistance
#16
Chinh Tran-To Su, Wei-Li Ling, Wai-Heng Lua, Yu-Xuan Haw, Samuel Ken-En Gan
BACKGROUND: Strategies to control HIV for improving the quality of patient lives have been aided by the Highly Active Anti-Retroviral Therapy (HAART), which consists of a cocktail of inhibitors targeting key viral enzymes. Numerous new drugs have been developed over the past few decades but viral resistances to these drugs in the targeted viral enzymes are increasingly reported. Nonetheless the acquired mutations often reduce viral fitness and infectivity. Viral compensatory secondary-line mutations mitigate this loss of fitness, equipping the virus with a broad spectrum of resistance against these drugs...
December 22, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28147228/association-of-intraocular-pressure-iop-with-human-immunodeficiency-virus-hiv
#17
Matthew T Young, Rakhi T Melvani, Faraaz A Khan, Puneet S Braich, Surbhi Bansal
PURPOSE: Prior studies have shown an association between human immunodeficiency virus (HIV) and reduced intraocular pressures (IOP). The purpose of this study was to determine if patients with HIV on highly active antiretroviral therapy (HAART) had any difference in their IOP compared to patients without HIV or with HIV who are not on HAART. DESIGN: Retrospective cross sectional study. METHODS: We included 400 patients from our academic eye center between 2000 and 2016...
January 29, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28132999/trends-and-characteristics-of-all-cause-mortality-among-hiv-infected-inpatients-during-the-haart-era-2006-2015-in-shanghai-china
#18
Yongjia Ji, Zhenyan Wang, Jiayin Shen, Jun Chen, Junyang Yang, Tangkai Qi, Wei Song, Yang Tang, Li Liu, Yinzhong Shen, Renfang Zhang, Hongzhou Lu
Globally, the overall mortality rate among HIV-infected patients has significantly declined during the HAART era. Deaths among HIV-infected inpatients need to be characterized in order to formulate intervention strategies to further improve medical care for this population and their prognosis. In the current study, deaths among HIV-infected inpatients from 2006 to 2015 at a medical center for HIV infection and AIDS patient care in Shanghai, China were retrospectively analyzed. Trends in mortality rates and the proportion of deaths caused by AIDS or non-AIDS-related illnesses were evaluated...
January 30, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28129756/a-cluster-randomised-controlled-trial-protocol-of-an-adapted-intervention-for-alcohol-use-disorders-in-people-living-with-hiv-and-aids-impact-on-alcohol-use-general-functional-ability-quality-of-life-and-adherence-to-haart
#19
Munyaradzi Madhombiro, Bazondlile Dube-Marimbe, Michelle Dube, Dixon Chibanda, Moleen Zunza, Simbarashe Rusakaniko, David Stewart, Soraya Seedat
BACKGROUND: Interventions for alcohol use disorders (AUDs) in HIV infected individuals have been primarily targeted at HIV risk reduction and improved antiretroviral treatment adherence. However, reduction in alcohol use is an important goal. Alcohol use affects other key factors that may influence treatment course and outcome. In this study the authors aim to administer an adapted intervention for AUDs to reduce alcohol use in people living with HIV/AIDS (PLWHA). METHODS: This study is a cluster randomised controlled trial at 16 HIV care clinics...
January 28, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28129254/regionally-specific-brain-volumetric-and-cortical-thickness-changes-in-hiv-infected-patients-in-the-haart-era
#20
Ryan Sanford, Ana Lucia Fernandez Cruz, Susan C Scott, Nancy E Mayo, Lesley K Fellows, BeauM Ances, D Louis Collins
BACKGROUND: Cognitive impairment still occurs in a substantial subset of HIV-infected patients, despite effective viral suppression with highly active antiretroviral therapy (HAART). Structural brain changes may provide clues about the underlying pathophysiology. This study provides a detailed spatial characterization of the pattern and extent of brain volume changes associated with HIV, and relates these brain measures to cognitive ability and clinical variables. METHODS: Multiple novel neuroimaging techniques (deformation-based morphometry, voxel-based morphometry and cortical modeling) were used to assess regional brain volumes in 125 HIV-infected patients and 62 HIV-uninfected individuals...
January 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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