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Factor-5 Lyden

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https://www.readbyqxmd.com/read/27025877/jak2-inhibition-sensitizes-resistant-egfr-mutant-lung-adenocarcinoma-to-tyrosine-kinase-inhibitors
#1
Sizhi P Gao, Qing Chang, Ninghui Mao, Laura A Daly, Robert Vogel, Tyler Chan, Shu Hui Liu, Eirini Bournazou, Erez Schori, Haiying Zhang, Monica Red Brewer, William Pao, Luc Morris, Marc Ladanyi, Maria Arcila, Katia Manova-Todorova, Elisa de Stanchina, Larry Norton, Ross L Levine, Gregoire Altan-Bonnet, David Solit, Michael Zinda, Dennis Huszar, David Lyden, Jacqueline F Bromberg
Lung adenocarcinomas with mutant epidermal growth factor receptor (EGFR) respond to EGFR-targeted tyrosine kinase inhibitors (TKIs), but resistance invariably occurs. We found that the Janus kinase (JAK)/signal transduction and activator of transcription 3 (STAT3) signaling pathway was aberrantly increased in TKI-resistant EGFR-mutant non-small cell lung cancer (NSCLC) cells. JAK2 inhibition restored sensitivity to the EGFR inhibitor erlotinib in TKI-resistant cell lines and xenograft models of EGFR-mutant TKI-resistant lung cancer...
March 29, 2016: Science Signaling
https://www.readbyqxmd.com/read/26961715/fractionated-stereotactic-radiation-therapy-for-vestibular-schwannomas-dosimetric-factors-predictive-of-hearing-outcomes
#2
Nathan R Bennion, Ryan K Nowak, Elizabeth R Lyden, Robert B Thompson, Sicong Li, Chi Lin
PURPOSE: To determine dosimetric factors predictive of hearing loss in vestibular schwannoma (VS) patients treated with definitive fractionated stereotactic radiation therapy (FSRT), and to report tumor control, serviceable hearing preservation, and cranial nerve toxicities. METHODS AND MATERIALS: We identified 45 patients (29 men and 16 women) with unilateral sporadic VS, who underwent definitive FSRT. All patients had serviceable hearing prior to treatment, defined as Gardner-Robertson Class 1 or 2...
September 2016: Practical Radiation Oncology
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