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Withdrawal of technology

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https://www.readbyqxmd.com/read/29685748/bed-ii-sequence-stratigraphic-context-of-ef-hr-and-hwk-ee-archaeological-sites-and-the-oldowan-acheulean-succession-at-olduvai-gorge-tanzania
#1
Ian G Stanistreet, Lindsay J McHenry, Harald Stollhofen, Ignacio de la Torre
Archaeological excavations at EF-HR and HWK EE allow reassessment of Bed II stratigraphy within the Junction Area and eastern Olduvai Gorge. Application of Sequence Stratigraphic methods provides a time-stratigraphic framework enabling correlation of sedimentary units across facies boundaries, applicable even in those areas where conventional timelines, such as tephrostratigraphic markers, are absent, eroded, or reworked. Sequence Stratigraphically, Bed II subdivides into five major Sequences 1 to 5, all floored by major disconformities that incise deeply into the underlying succession, proving that simple "layer cake" stratigraphy is inappropriate...
April 20, 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29682052/venous-air-embolism-during-endoscopic-third-ventriculostomy
#2
Renu Bala, Mihir P Pandia
Neuroendoscopic procedures are increasingly performed nowadays due to the significant technological improvement of endoscopic instrumentation. It carries various advantages such as speed, simplicity, avoidance of implants, and no brain dissection or retraction. Although considered to be safe, it is associated with a host of complications. We hereby report a case of venous air embolism in an infant who was undergoing endoscopic third ventriculostomy. The complication occurred at the completion of surgery when surgeons were withdrawing the endoscope...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29669554/a-g-o-type-opsin-mediates-the-shadow-reflex-in-the-annelid-platynereis-dumerilii
#3
Thomas Ayers, Hisao Tsukamoto, Martin Gühmann, Vinoth Babu Veedin Rajan, Kristin Tessmar-Raible
BACKGROUND: The presence of photoreceptive molecules outside the eye is widespread among animals, yet their functions in the periphery are less well understood. Marine organisms, such as annelid worms, exhibit a 'shadow reflex', a defensive withdrawal behaviour triggered by a decrease in illumination. Herein, we examine the cellular and molecular underpinnings of this response, identifying a role for a photoreceptor molecule of the Go -opsin class in the shadow response of the marine bristle worm Platynereis dumerilii...
April 18, 2018: BMC Biology
https://www.readbyqxmd.com/read/29656722/toward-a-contingency-model-for-hospital-based-health-technology-assessment-evidence-from-adhophta-project
#4
Americo Cicchetti, Valentina Iacopino, Silvia Coretti, Alessandra Fiore, Marco Marchetti, Laura Sampietro-Colom, Kristian Kidholm, Jean-Blaise Wasserfallen, Rabia Kahveci, Esa Halmesmäki, Magdalene Rosenmöller, Claudia Wild, Raul-Allan Kivet
OBJECTIVES: Hospital-based health technology assessment (HB-HTA) is becoming increasingly relevant because of its role in managing the introduction and withdrawal of health technologies. The organizational arrangement in which HB-HTA activities are conducted depends on several contextual factors, although the dominant models have several similarities. The aims of this study were to explore, describe, interpret, and explain seven cases of the application of HB-HTA logic and to propose a classification for HB-HTA organizational models which may be beneficial for policy makers and HTA professionals...
April 16, 2018: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29608947/microencapsulated-schwann-cell-transplantation-inhibits-p2x2-3-receptors-overexpression-in-a-sciatic-nerve-injury-rat-model-with-neuropathic-pain
#5
Ya-Ling Zhang, Yi-Guo Liu, De-Jian Chen, Bao-Lin Yang, Tao-Tao Liu, Jia-Juan Li, Xiu-Qi Wang, Hao-Tian Rose Li, Zeng-Xu Liu
Transplantation of Schwann cells (SCs) can promote axonal regeneration and formation of the myelin sheath, reduce inflammation, and promote repair to the damaged nerve. Our previous studies have shown that transplantation of free or micro-encapsulated olfactory ensheathing cells can relieve neuropathic pain. There are no related reports regarding whether the transplantation of micro-encapsulated SCs can alleviate neuropathic pain mediated by P2X2/3 receptors. In the present study, we micro-encapsulated SCs in alginic acid and transplanted them into the region surrounding the injured sciatic nerve in the rat model of chronic constriction injury (CCI)...
March 30, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29603595/integrated-technological-and-management-solutions-for-wastewater-treatment-and-efficient-agricultural-reuse-in-egypt-morocco-and-tunisia
#6
REVIEW
Dario Frascari, Giulio Zanaroli, Mohamed Abdel Motaleb, Giorgio Annen, Khaoula Belguith, Sara Borin, Redouane Choukr-Allah, Catherine Gibert, Atef Jaouani, Nicolas Kalogerakis, Fawzi Karajeh, Philippe A Ker Rault, Roula Khadra, Stathis Kyriacou, Wen-Tao Li, Bruno Molle, Marijn Mulder, Emmanuel Oertlé, Consuelo Varela Ortega
Mediterranean African Countries (MACs) face a major water crisis. The annual renewable water resources are close to the 500 m3 /capita threshold of absolute water scarcity, and water withdrawals exceed total renewable water resources by 30%. Such a low water availability curbs economic development in particular in the field of agriculture, that accounts for 86% of freshwater consumption. The analysis of the current situation of wastewater treatment, irrigation and water management in MACs and of the research projects targeted to these countries indicates the need for i) an enhanced capacity to analyze water stress, ii) the development of water management strategies capable to include wastewater reuse, and iii) development of locally-adapted water treatment and irrigation technologies...
March 30, 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29590514/one-ventilator-too-few
#7
Noah Polzin-Rosenberg
Sometimes it's better to be lucky than good. As new blood filled our young patient's veins, her breathing became regular and her pulse full. She was so far gone I would not have expected her to recover consciousness for a day, if at all, but within an hour, she began to wake up. We removed the breathing tube a couple of hours later- no ventilator ever needed. As life-sustaining technology becomes more widely available in fortunate parts of the developing world, benefits come with complications. The temptation is to focus on the thing-the ventilator itself-as the crucial element and press to buy more, mistaking the problem for one of resource scarcity only...
March 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29577950/primary-deuterium-kinetic-isotope-effects-prolong-drug-release-and-polymer-biodegradation-in-a-drug-delivery-system
#8
Brian R Hearn, Shaun D Fontaine, Samuel J Pfaff, Eric L Schneider, Jeff Henise, Gary W Ashley, Daniel V Santi
We have developed a chemically-controlled drug delivery system in which a drug is covalently attached via a carbamate to hydrogel microspheres using a β-eliminative linker; rate-determining proton removal from a CH bond adjacent to an electron withdrawing group results in a β-elimination to cleave the carbamate and release the drug. After subcutaneous injection of the hydrogel-drug conjugate, the drug is slowly released into the systemic circulation and acquires an elimination t1/2,β that matches the t1/2 of linker cleavage...
March 22, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29574507/new-steps-for-treating-alcohol-use-disorder
#9
REVIEW
Erin J Campbell, Andrew J Lawrence, Christina J Perry
Alcohol use disorder is a complex syndrome with multiple treatment points including drug-induced pathology, withdrawal management, behavioral/cognitive strategies, and relapse prevention. These different components may be complicated by genotype and phenotype. A huge milestone for the treatment of alcohol use disorder across several countries in the last 10 years was the introduction of practice guidelines integrating clinical expertise and research evidence. These provide a summary of interventions that have been shown to be effective following rigorous and replicated clinical trials...
March 25, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29492382/current-state-of-pediatric-cardiac-transplantation
#10
REVIEW
Anne I Dipchand
Pediatric heart transplantation is standard of care for children with end-stage heart failure. The diverse age range, diagnoses, and practice variations continue to challenge the development of evidence-based practices and new technologies. Outcomes in the most recent era are excellent, especially with the more widespread use of ventricular assist devices (VADs). Waitlist mortality remains high and knowledge of risk factors for death while waiting and following transplantation contributes to decision-making around transplant candidacy and timing of listing...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29482614/improving-pain-treatment-with-a-smartphone-app-study-protocol-for-a-randomized-controlled-trial
#11
Carlos Suso-Ribera, Ángela Mesas, Javier Medel, Anna Server, Esther Márquez, Diana Castilla, Irene Zaragozá, Azucena García-Palacios
BACKGROUND: Chronic pain has become a major health problem across the world, especially in older adults. Unfortunately, the effectiveness of medical interventions is modest. Some have argued that assessment strategies should be improved if the impact of medical interventions is to be improved. Ecological momentary assessment using smartphones is now considered the gold standard in monitoring in health settings, including chronic pain. However, to the best of our knowledge, there is no randomized controlled trial to show that telemonitoring using a smartphone app can indeed improve the effectiveness of medical treatments in adults with chronic pain...
February 27, 2018: Trials
https://www.readbyqxmd.com/read/29464812/the-female-continence-mechanism-measured-by-high-resolution-manometry-urethral-bulking-versus-midurethral-sling
#12
Erika J Wasenda, Anna C Kirby, Emily S Lukacz, Charles W Nager
AIMS: Traditional technology to characterize urethral pressure changes during dynamic conditions is limited by slow response times or artifact-inducing withdrawal maneuvers. The 8F high-resolution manometry (HRM) catheter (ManoScan™ ESO, Covidien) has advantages of fast response times and the ability to measure urethral pressures along the urethral length without withdrawal. Our objective was to determine static and dynamic maximum urethral closure pressures (MUCPs) and resting functional urethral length (FUL) in women using HRM before and after transurethral bulking and compare results to other women who underwent midurethral sling (MUS)...
February 21, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29440801/a-retrospective-study-of-end-of-life-care-decisions-in-the-critically-ill-in-a-surgical-intensive-care-unit
#13
Yi Lin Lee, Yee Yian Ong, Sze Ying Thong, Shin Yi Ng
Aim: Progress in medical care and technology has led to patients with more advanced illnesses being admitted to the Intensive Care Unit (ICU). The practice of approaching end-of-life (EOL) care decisions and limiting care is well documented in Western literature but unknown in Singapore. We performed a retrospective cohort study to describe the practice of EOL care in patients dying in a Singapore surgical ICU (SICU). The surgical critical care population was chosen as it is unique because surgeons are frequently involved in the EOL process...
January 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29415286/gaze-patterns-hold-key-to-unlocking-successful-search-strategies-and-increasing-polyp-detection-rate-in-colonoscopy
#14
Mariam Lami, Harsimrat Singh, James H Dilley, Hajra Ashraf, Matthew Edmondon, Felipe Orihuela-Espina, Jonathan Hoare, Ara Darzi, Mikael H Sodergren
BACKGROUND:  The adenoma detection rate (ADR) is an important quality indicator in colonoscopy. The aim of this study was to evaluate the changes in visual gaze patterns (VGPs) with increasing polyp detection rate (PDR), a surrogate marker of ADR. METHODS:  18 endoscopists participated in the study. VGPs were measured using eye-tracking technology during the withdrawal phase of colonoscopy. VGPs were characterized using two analyses - screen and anatomy. Eye-tracking parameters were used to characterize performance, which was further substantiated using hidden Markov model (HMM) analysis...
February 7, 2018: Endoscopy
https://www.readbyqxmd.com/read/29397321/using-metabolomics-to-investigate-biomarkers-of-drug-addiction
#15
REVIEW
Reza Ghanbari, Susan Sumner
Drug addiction has been associated with an increased risk for cancer, psychological complications, heart, liver, and lung disease, as well as infection. While genes have been identified that can mark individuals at risk for substance abuse, the initiation step of addiction is attributed to persistent metabolic disruptions occurring following the first instance of narcotic drug use. Advances in analytical technologies can enable the detection of thousands of signals in body fluids and excreta that can be used to define biochemical profiles of addiction...
January 31, 2018: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/29382308/endomyocardial-biopsy-guided-by-intracardiac-echocardiography-as-a-key-step-in-intracardiac-mass-diagnosis
#16
Marco Zanobini, Antonio Dello Russo, Matteo Saccocci, Sergio Conti, Elisa De Camilli, Giulia Vettor, Valentina Catto, Maurizio Roberto, Cesare Fiorentini, Giuseppe Viale, Claudio Tondo, Michela Casella
BACKGROUND: Based on a plenty of different applications, intracardiac echocardiography (ICE) is now a well-established technology in complex electrophysiological procedures. Recently, ICE has become the most widely used ultrasound-based imaging tool to guide diagnostic endomyocardial biopsy (EMB). EMB of cardiac mass guided by ICE is an interesting application of ICE. Allowing a correct positioning of the bioptome, ICE reduce the procedure-related risks and the need of a diagnostic open-chest procedure reserving the more invasive approach to selected cases...
January 30, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29374344/assessment-of-antimicrobial-drug-administration-and-antimicrobial-residues-in-food-animals-in-enugu-state-nigeria
#17
Emmanuel Okechukwu Njoga, Joseph I Onunkwo, Chinwe E Okoli, Wilfred I Ugwuoke, John A Nwanta, Kennedy F Chah
Imprudent administration of antimicrobial drugs in food-producing animals can facilitate the development and spread of antimicrobial-resistant organisms and also enhance the occurrence of antimicrobial residue in animal products. This study was undertaken to assess antimicrobial drug administration to food animals in livestock farms in Enugu State and determine livestock farmers' awareness on the consequences of imprudent antimicrobial administration to food animals and finally the prevalence of antimicrobial drug residues in edible tissues of cattle and pigs in the state...
April 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29324429/a-pilot-clinical-study-of-a-safe-and-efficient-stool-management-system-in-patients-with-fecal-incontinence
#18
Ashlee Garcia, Sally Fung, Karen Lou Kennedy-Evans
INTRODUCTION: According to the Wound Ostomy Continence Nursing Society's Continence Committee, the incidence of fecal incontinence (FI) can occur from 18% to 37% in an acute care setting. A stool management system has been designed to manage FI in bedridden patients and has proven to be efficacious in wound management and prevention and infection control, provide safer patient outcomes, and enhance ease of nursing. OBJECTIVE: This study aims to evaluate the safety and efficacy of an intrarectal device intended to manage fecal incontinence in hospitalized bedridden patients through nonclinical and clinical testings...
December 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29260740/-hepatitis-c-can-be-cured-will-hepatitis-b-become-next
#19
REVIEW
V P Chulanov, A P Zueva, D S Kostyushev, S A Brezgin, E V Volchkova, V V Maleyev
Chronic hepatitis B (CHB) and C (CHC) are one of the leading causes of cirrhosis and liver cancer with over a million of people dying annually from their consequences. In Russia CHB and CHC morbidity and related mortality show an upward trend. As a result of recent breakthroughs in antiviral therapeutics CHC became a curable disease. Modern therapeutics effectively suppress viral replication in CHB patients, but withdrawal of antivirals usually results in disease relapse. Loss of HBsAg required for the so called 'functional cure' is a very rare event...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29246661/a-quantitative-approach-to-neuropsychiatry-the-why-and-the-how
#20
REVIEW
Martien J Kas, Brenda Penninx, Bernd Sommer, Alessandro Serretti, Celso Arango, Hugh Marston
The current nosology of neuropsychiatric disorders allows for a pragmatic approach to treatment choice, regulation and clinical research. However, without a biological rationale for these disorders, drug development has stagnated. The recently EU-funded PRISM project aims to develop a quantitative biological approach to the understanding and classification of neuropsychiatric diseases to accelerate the discovery and development of better treatments. By combining clinical data sets from major worldwide disease cohorts and by applying innovative technologies to deeply phenotype stratified patient groups, we will define a set of quantifiable biological parameters for social withdrawal and cognitive deficits common to Schizophrenia (SZ), Major Depression (MD), and Alzheimer's Disease (AD)...
December 12, 2017: Neuroscience and Biobehavioral Reviews
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