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https://www.readbyqxmd.com/read/28626990/exhaled-breath-profiles-in-the-monitoring-of-loss-of-control-and-clinical-recovery-in-asthma
#1
Paul Brinkman, Marianne A van de Pol, Marije G Gerritsen, Lieuwe D Bos, Tamara Dekker, Barbara S Smids, Anirban Sinha, Christof J Majoor, Marlous M Sneeboer, Hugo H Knobel, Teunis J Vink, Frans H de Jongh, René Lutter, Peter J Sterk, Niki Fens
BACKGROUND: Asthma is a chronic inflammatory airway disease, associated with episodes of exacerbations. Therapy with inhaled corticosteroids (ICS) targets airway inflammation, which aims to maintain and restore asthma control. Clinical features are only modestly associated with airways inflammation. Therefore, we hypothesized that exhaled volatile metabolites identify longitudinal changes between clinically stable episodes and loss of asthma control. OBJECTIVES: To determine whether exhaled volatile organic compounds (VOCs) as measured by gas-chromatography / mass-spectrometry (GC/MS) and electronic nose (eNose) technology discriminate between clinically stable and unstable episodes of asthma...
June 19, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28608846/quickcash-secure-transfer-payment-systems
#2
Abdulrahman Alhothaily, Arwa Alrawais, Tianyi Song, Bin Lin, Xiuzhen Cheng
Payment systems play a significant role in our daily lives. They are an important driver of economic activities and a vital part of the banking infrastructure of any country. Several current payment systems focus on security and reliability but pay less attention to users' needs and behaviors. For example, people may share their bankcards with friends or relatives to withdraw money for various reasons. This behavior can lead to a variety of privacy and security issues since the cardholder has to share a bankcard and other sensitive information such as a personal identification number (PIN)...
June 13, 2017: Sensors
https://www.readbyqxmd.com/read/28589627/benzothiazolium-single-crystals-a-new-class-of-nonlinear-optical-crystals-with-efficient-thz-wave-generation
#3
Seung-Heon Lee, Jian Lu, Seung-Jun Lee, Jae-Hyun Han, Chan-Uk Jeong, Seung-Chul Lee, Xian Li, Mojca Jazbinšek, Woojin Yoon, Hoseop Yun, Bong Joo Kang, Fabian Rotermund, Keith A Nelson, O-Pil Kwon
Highly efficient nonlinear optical organic crystals are very attractive for various photonic applications including terahertz (THz) wave generation. Up to now, only two classes of ionic crystals based on either pyridinium or quinolinium with extremely large macroscopic optical nonlinearity have been developed. This study reports on a new class of organic nonlinear optical crystals introducing electron-accepting benzothiazolium, which exhibit higher electron-withdrawing strength than pyridinium and quinolinium in benchmark crystals...
June 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28582325/astroglial-microrna-219-5p-in-the-ventral-tegmental-area-regulates-nociception-in-rats
#4
Song Zhang, Xiao-Na Yang, Ting Zang, Jun Luo, Zhiqiang Pan, Lei Wang, He Liu, Di Liu, Yan-Qiang Li, Yao-Dong Zhang, Hongxing Zhang, Hai-Lei Ding, Jun-Li Cao
BACKGROUND: The authors previously reported that noncoding microRNA miR-219-5p is down-regulated in the spinal cord in a nociceptive state. The ventral tegmental area also plays critical roles in modulating nociception, although the underlying mechanism remains unknown. The authors hypothesized that miR-219-5p in the ventral tegmental area also may modulate nociception. METHODS: The authors studied the bidirectional regulatory role of ventral tegmental area miR-219-5p in a rat complete Freund's adjuvant model of inflammatory nociception by measuring paw withdrawal latencies...
June 5, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28580238/rapid-breeding-and-varietal-replacement-are-critical-to-adaptation-of-cropping-systems-in-the-developing-world-to-climate-change
#5
REVIEW
Gary N Atlin, Jill E Cairns, Biswanath Das
Plant breeding is a key mechanism for adaptation of cropping systems to climate change. Much discussion of breeding for climate change focuses on genes with large effects on heat and drought tolerance, but phenology and stress tolerance are highly polygenic. Adaptation will therefore mainly result from continually adjusting allele frequencies at many loci through rapid-cycle breeding that delivers a steady stream of incrementally improved cultivars. This will require access to elite germplasm from other regions, shortened breeding cycles, and multi-location testing systems that adequately sample the target population of environments...
March 2017: Global Food Security
https://www.readbyqxmd.com/read/28496440/fc%C3%AE-chimeric-receptor-engineered-t-cells-methodology-advantages-limitations-and-clinical-relevance
#6
REVIEW
Sara Caratelli, Tommaso Sconocchia, Roberto Arriga, Andrea Coppola, Giulia Lanzilli, Davide Lauro, Adriano Venditti, Maria Ilaria Del Principe, Francesco Buccisano, Luca Maurillo, Soldano Ferrone, Giuseppe Sconocchia
For many years, disappointing results have been generated by many investigations, which have utilized a variety of immunologic strategies to enhance the ability of a patient's immune system to recognize and eliminate malignant cells. However, in recent years, immunotherapy has been used successfully for the treatment of hematologic and solid malignancies. The impressive clinical responses observed in many types of cancer have convinced even the most skeptical clinical oncologists that a patient's immune system can recognize and reject his tumor if appropriate strategies are implemented...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28490417/accelerating-digital-mental-health-research-from-early-design-and-creation-to-successful-implementation-and-sustainment
#7
David C Mohr, Aaron R Lyon, Emily G Lattie, Madhu Reddy, Stephen M Schueller
Mental health problems are common and pose a tremendous societal burden in terms of cost, morbidity, quality of life, and mortality. The great majority of people experience barriers that prevent access to treatment, aggravated by a lack of mental health specialists. Digital mental health is potentially useful in meeting the treatment needs of large numbers of people. A growing number of efficacy trials have shown strong outcomes for digital mental health treatments. Yet despite their positive findings, there are very few examples of successful implementations and many failures...
May 10, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28442453/clickotine-a-personalized-smartphone-app-for-smoking-cessation-initial-evaluation
#8
Brian M Iacoviello, Joshua R Steinerman, David B Klein, Theodore L Silver, Adam G Berger, Sean X Luo, Nicholas J Schork
BACKGROUND: Tobacco smoking is the leading cause of preventable death in the United States, and the annual economic burden attributable to smoking exceeds US $300 billion. Obstacles to smoking cessation include limited access and adherence to effective cessation interventions. Technology can help overcome these obstacles; many smartphone apps have been developed to aid smoking cessation, but few that conform to the US clinical practice guideline (USCPG) have been rigorously tested and reported in the literature...
April 25, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28398839/foundational-and-translational-research-opportunities-to-improve-plant-health
#9
Richard Michelmore, Gitta Coaker, Rebecca Bart, Gwyn Beattie, Andrew Bent, Toby Bruce, Duncan Cameron, Jeffery Dangl, Savithramma Dinesh-Kumar, Rob Edwards, Sebastian Eves-van den Akker, Walter Gassmann, Jean T Greenberg, Linda Hanley-Bowdoin, Richard J Harrison, Jagger Harvey, Ping He, Alisa Huffaker, Scot Hulbert, Roger Innes, Jonathan D G Jones, Isgouhi Kaloshian, Sophien Kamoun, Fumiaki Katagiri, Jan Leach, Wenbo Ma, John McDowell, June Medford, Blake Meyers, Rebecca Nelson, Richard Oliver, Yiping Qi, Diane Saunders, Michael Shaw, Christine Smart, Prasanta Subudhi, Lesley Torrance, Bret Tyler, Barbara Valent, John Walsh
Reader Comments | Submit a Comment The white paper reports the deliberations of a workshop focused on biotic challenges to plant health held in Washington, D.C. in September 2016. Ensuring health of food plants is critical to maintaining the quality and productivity of crops and for sustenance of the rapidly growing human population. There is a close linkage between food security and societal stability; however, global food security is threatened by the vulnerability of our agricultural systems to numerous pests, pathogens, weeds, and environmental stresses...
July 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28382404/prediction-of-hepatotoxicity-for-drugs-using-human-pluripotent-stem-cell-derived-hepatocytes
#10
Jong Hyun Kim, Min Wang, Jaehun Lee, Han-Jin Park, Chungseong Han, Hee Su Hong, Jeong Seong Kim, Geun Ho An, Kijung Park, Hee-Kyung Park, Shi Feng Zhu, Xiao-Bo Sun, Jong-Hoon Kim, Dong-Hun Woo
Drug-induced liver toxicity is a main reason for withdrawals of new drugs in late clinical phases and post-launch of the drugs. Thus, hepatotoxicity screening of drug candidates in pre-clinical stage is important for reducing drug attrition rates during the clinical development process. Here, we show commercially available hepatocytes that could be used for early toxicity evaluation of drug candidates. From our hepatic differentiation technology, we obtained highly pure (≥98%) hepatocytes from human embryonic stem cells (hESCs) having mature phenotypes and similar gene expression profiles with those of primary human tissues...
April 5, 2017: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/28377799/electronic-tuning-of-self-healing-fluorophores-for-live-cell-and-single-molecule-imaging
#11
Qinsi Zheng, Steffen Jockusch, Zhou Zhou, Roger B Altman, Hong Zhao, Wesley Asher, Michael Holsey, Signe Mathiasen, Peter Geggier, Jonathan A Javitch, Scott C Blanchard
Bright, long-lasting organic fluorophores enable a broad range of imaging applications. "Self-healing" fluorophores, in which intra-molecularly linked protective agents quench photo-induced reactive species, exhibit both enhanced photostability and biological compatibility. However, the self-healing strategy has yet to achieve its predicted potential, particularly in the presence of ambient oxygen where live-cell imaging studies must often be performed. To identify key bottlenecks in this technology that can be used to guide further engineering developments, we synthesized a series of Cy5 derivatives linked to the protective agent cyclooctatetraene (COT) and examined the photophysical mechanisms curtailing their performance...
January 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28374934/the-hfea-should-be-regulating-add-on-treatments-for-ivf-icsi
#12
William L Ledger
The HFEA has come a long way since its inception in 1990. Public and professional concern was initially focused on the many ethical challenges presented by the new technologies used in ART, and in particular the need for consideration of the welfare of children that may be born after their use. Hence much of the time of the HFEA is spent on matters pertaining to medical ethics, such as reduction of the multiple embryo transfer rate (improving the health of ART children by avoiding multiple pregnancy), and identification of gamete donors to their offspring...
April 4, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28361077/extra-corporeal-membrane-oxygenation-support-ethical-dilemmas
#13
EDITORIAL
Tony Makdisi, George Makdisi
The vast expansion of patients treated with of extra corporeal membrane oxygenation (ECMO) emerge novel ethical questions about the use of this new technology. In regard the indications, duration of support and timing of withdrawal of support, these questions sometimes create disagreement among surrogates, between health care team and surrogates, and even disagreement among health care team, these disagreements occurs because of the extreme emergency of support initiation, the ambiguity of the outcome as well as lack of clarity on the intended treatment direction, whether it is ineffective, bridge to recovery or bridge to lifetime mechanical support or transplant...
March 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28333391/high-performance-nonfullerene-polymer-solar-cells-based-on-imide-functionalized-wide-bandgap-polymers
#14
Baobing Fan, Kai Zhang, Xiao-Fang Jiang, Lei Ying, Fei Huang, Yong Cao
High-performance nonfullerene polymer solar cells (PSCs) are developed by integrating the nonfullerene electron-accepting material 3,9-bis(2-methylene-(3-(1,1-dicyanomethylene)-indanone))-5,5,11,11-tetrakis(4-hexylphenyl)-dithieno[2,3-d:2',3'-d']-s-indaceno[1,2-b:5,6-b']dithiophne) (ITIC) with a wide-bandgap electron-donating polymer PTzBI or PTzBI-DT, which consists of an imide functionalized benzotriazole (TzBI) building block. Detailed investigations reveal that the extension of conjugation can affect the optical and electronic properties, molecular aggregation properties, charge separation in the bulk-heterojunction films, and thus the overall photovoltaic performances...
June 2017: Advanced Materials
https://www.readbyqxmd.com/read/28324707/chemical-structure-based-predictive-model-for-the-oxidation-of-trace-organic-contaminants-by-sulfate-radical
#15
Tiantian Ye, Zongsu Wei, Richard Spinney, Chong-Jian Tang, Shuang Luo, Ruiyang Xiao, Dionysios D Dionysiou
Second-order rate constants [Formula: see text] for the reaction of sulfate radical anion (SO4(•-)) with trace organic contaminants (TrOCs) are of scientific and practical importance for assessing their environmental fate and removal efficiency in water treatment systems. Here, we developed a chemical structure-based model for predicting [Formula: see text] using 32 molecular fragment descriptors, as this type of model provides a quick estimate at low computational cost. The model was constructed using the multiple linear regression (MLR) and artificial neural network (ANN) methods...
June 1, 2017: Water Research
https://www.readbyqxmd.com/read/28258049/using-mobile-sensing-to-test-clinical-models-of-depression-social-anxiety-state-affect-and-social-isolation-among-college-students
#16
Philip I Chow, Karl Fua, Yu Huang, Wesley Bonelli, Haoyi Xiong, Laura E Barnes, Bethany A Teachman
BACKGROUND: Research in psychology demonstrates a strong link between state affect (moment-to-moment experiences of positive or negative emotionality) and trait affect (eg, relatively enduring depression and social anxiety symptoms), and a tendency to withdraw (eg, spending time at home). However, existing work is based almost exclusively on static, self-reported descriptions of emotions and behavior that limit generalizability. Despite adoption of increasingly sophisticated research designs and technology (eg, mobile sensing using a global positioning system [GPS]), little research has integrated these seemingly disparate forms of data to improve understanding of how emotional experiences in everyday life are associated with time spent at home, and whether this is influenced by depression or social anxiety symptoms...
March 3, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28231153/microbial-proteases-in-baked-goods-modification-of-gluten-and-effects-on-immunogenicity-and-product-quality
#17
REVIEW
Nina G Heredia-Sandoval, Maribel Y Valencia-Tapia, Ana M Calderón de la Barca, Alma R Islas-Rubio
Gluten-related diseases are a range of inflammatory disorders of the small intestine, characterized by an adverse response to gluten ingestion; therefore, the treatment is a gluten withdrawal. In spite of the increased market of gluten-free products, widely available breads with high acceptability are still missing due to the technological challenge of substituting the special gluten properties. Instead of using alternative ingredients for baking, some attempts have been done to decrease gluten immunogenicity by its enzymatic degradation with microbial proteases...
August 30, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28220988/-the-gaze-heuristic-biography-of-an-adaptively-rational-decision-process
#18
Robert P Hamlin
This article is a case study that describes the natural and human history of the gaze heuristic. The gaze heuristic is an interception heuristic that utilizes a single input (deviation from a constant angle of approach) repeatedly as a task is performed. Its architecture, advantages, and limitations are described in detail. A history of the gaze heuristic is then presented. In natural history, the gaze heuristic is the only known technique used by predators to intercept prey. In human history the gaze heuristic was discovered accidentally by Royal Air Force (RAF) fighter command just prior to World War II...
February 21, 2017: Topics in Cognitive Science
https://www.readbyqxmd.com/read/28213582/a-scale-up-mock-up-comparison-of-student-learning-gains-in-high-and-low-tech-active-learning-environments
#19
Paula A G Soneral, Sara A Wyse
Student-centered learning environments with upside-down pedagogies (SCALE-UP) are widely implemented at institutions across the country, and learning gains from these classrooms have been well documented. This study investigates the specific design feature(s) of the SCALE-UP classroom most conducive to teaching and learning. Using pilot survey data from instructors and students to prioritize the most salient SCALE-UP classroom features, we created a low-tech "Mock-up" version of this classroom and tested the impact of these features on student learning, attitudes, and satisfaction using a quasi--experimental setup...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28212952/the-challenge-of-conditional-reimbursement-stopping-reimbursement-can-be-more-difficult-than-not-starting-in-the-first-place
#20
E J van de Wetering, Job van Exel, Werner B F Brouwer
BACKGROUND: Conditional reimbursement of new health technologies is increasingly considered as a useful policy instrument. It allows gathering more robust evidence regarding effectiveness and cost-effectiveness of new technologies without delaying market access. Nevertheless, the literature suggests that ending reimbursement and provision of a technology when it proves not to be effective or cost-effective in practice may be difficult. OBJECTIVES: To investigate how policymakers and the general public in the Netherlands value removing a previously reimbursed treatment from the basic benefits package relative to not including a new treatment...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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