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Withdrawal of technology

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https://www.readbyqxmd.com/read/29910710/supplemental-stimulation-improves-swing-phase-kinematics-during-exoskeleton-assisted-gait-of-sci-subjects-with-severe-muscle-spasticity
#1
Andrew Ekelem, Michael Goldfarb
Spasticity is a common comorbidity associated with spinal cord injury (SCI). Robotic exoskeletons have recently emerged to facilitate legged mobility in people with motor complete SCI. Involuntary muscle activity attributed to spasticity, however, can prevent such individuals from using an exoskeleton. Specifically, although most exoskeleton technologies can accommodate low to moderate spasticity, the presence of moderate to severe spasticity can significantly impair gait kinematics when using an exoskeleton...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29895837/technoference-longitudinal-associations-between-parent-technology-use-parenting-stress-and-child-behavior-problems
#2
Brandon T McDaniel, Jenny S Radesky
BACKGROUND AND OBJECTIVES: Heavy parent digital technology use has been associated with suboptimal parent-child interactions and internalizing/externalizing child behavior, but directionality of associations is unclear. This study aims to investigate longitudinal bidirectional associations between parent technology use and child behavior, and understand whether this is mediated by parenting stress. METHODS: Participants included 183 couples with a young child (age 0-5 years, mean = 3...
June 13, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29870523/effect-of-sirtuin-1-on-synaptic-plasticity-in-nucleus-accumbens-in-a-rat-model-of-heroin-addiction
#3
Baijuan Xia, Yixin Li, Rongrong Li, Dan Yin, Xingqiang Chen, Jie Li, Wenmei Liang
BACKGROUND Synaptic plasticity plays an important role in the process of addiction. This study investigated the relationship between synaptic plasticity and changes in addictive behavior and examined the expression of synaptic plasticity-associated proteins and genes in the nucleus accumbens (NAc) region in different rat models. MATERIAL AND METHODS Heroin addiction, SIRT1-overexpression, and SIRT1-silenced rat models were established. Polymerase chain reaction gene chip technology, immunohistochemistry, Western blotting, and transmission electron microscopy were used to detect changes in synaptic plasticity-related gene and protein expression, and changes in the ultrastructure of synapses, in the NAc...
June 5, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29859048/entrapment-of-a-laryngotracheal-topical-anesthesia-kit-during-tracheobronchial-foreign-body-removal-a-case-report
#4
Xi-Yang Zhang, Yun Han, Ya-Bing Zhang, Ke-Xuan Liu, Bin Liu
BACKGROUND: In order to reduce the irritation of the airway during tracheobronchial foreign body (TFB) removal, tracheal surface anesthesia is usually performed using a laryngotracheal topical anesthesia (LTA) kit (LTA20, Highgreen Medical Technology Company, China), but difficulty in withdrawing the LTA kit is rarely reported. We present a case of a difficulty to withdraw the LTA kit due to its entrapment by the movement of a TFB. CASE PRESENTATION: A 1-year-old girl was undergoing TFB removal...
June 1, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29798584/-application-of-three-dimensional-printing-technology-for-closed-reduction-and-percutaneous-cannulated-screws-fixation-of-displaced-intraarticular-calcaneus-fractures
#5
Min Wu, Jianzhong Guan, Yuzhou Xiao, Zhaodong Wang, Xiaotian Chen, Zhi Zhao, Kuankuan Zhang, Jun Zhu
Objective: To evaluate the effectiveness of three-dimensional (3-D) printing assisting minimally invasive for intraarticular calcaneal fractures with percutaneous poking reduction and cannulate screw fixation. Methods: A retrospective analysis was performed of the 19 patients (19 feet) with intraarticular calcaneal fracture who had been treated between March 2015 and May 2016. There were 13 males and 6 females with an average age of 38.2 years (range, 24-73 years)...
November 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29786562/application-of-hepatocyte-like-cells-to-enhance-hepatic-safety-risk-assessment-in-drug-discovery
#6
REVIEW
Dominic P Williams
Hepatic stress and injury from drugs continues to be a major concern within the pharmaceutical industry, leading to preclinical and clinical attrition precautionary warnings and post-market withdrawal of drugs. There is a requirement for more predictive and mechanistically accurate models to aid risk assessment. Primary human hepatocytes, subject to isolation stress, cryopreservation, donor-to-donor variation and a relatively short period of functional capability in two-dimensional cultures, are not suitable for high-throughput screening procedures...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29786560/microfabrication-of-liver-and-heart-tissues-for-drug-development
#7
REVIEW
Grace E Brown, Salman R Khetani
Drug-induced liver- and cardiotoxicity remain among the leading causes of preclinical and clinical drug attrition, marketplace drug withdrawals and black-box warnings on marketed drugs. Unfortunately, animal testing has proven to be insufficient for accurately predicting drug-induced liver- and cardiotoxicity across many drug classes, likely due to significant differences in tissue functions across species. Thus, the field of in vitro human tissue engineering has gained increasing importance over the last 10 years...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29771560/khat-withdrawal-symptoms-among-chronic-khat-users-following-a-quit-attempt-an-ecological-momentary-assessment-study
#8
Samson W Duresso, Raimondo Bruno, Allison J Matthews, Stuart G Ferguson
Research reports show increased prevalence of habitual khat chewing among various parts of the community in Ethiopia. Some users experience problems controlling their use; withdrawal symptoms may be adding to difficulties with reducing or ceasing use. We aimed to describe the nature and the time course of any withdrawal syndrome in relation to the cessation of khat use over the first 2 weeks of a quit attempt. Fifty-nine participants between the ages of 18 and 35 and who have already chewed ≥1 bundle of khat in their life with a chewing frequency of ≥3 days per week were recruited from Adama Science and Technology University campus...
May 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29755598/efficacy-of-an-sms-based-smoking-intervention-using-message-self-authorship-a-pilot-study
#9
Krista L DeStasio, Anne P Hill, Elliot T Berkman
Introduction: Text-message-based interventions hold great potential for intervention and are increasingly feasible, given advances in information technology. Aims: This pilot randomized controlled trial (RCT) aims to compare the efficacy of self-versus expert-authored content delivered via text-messaging for smoking cessation. Methods: Sixty-two participants aged 25-66 attended laboratory sessions pre- and post-30 days of text-messaging intervention...
March 2018: Journal of Smoking Cessation
https://www.readbyqxmd.com/read/29722533/advancing-predictive-hepatotoxicity-at-the-intersection-of-experimental-in-silico-and-artificial-intelligence-technologies
#10
Keith Fraser, Dylan M Bruckner, Jonathan S Dordick
Adverse drug reactions (ADRs), particularly those that result in drug-induced liver injury (DILI) is a major cause of drug failure in clinical trials and drug withdrawals. Hepatotoxicity-mediated drug attrition occurs despite substantial investments of time and money in developing cellular assays, animal models and computational models to predict its occurrence in humans. Underperformance in predicting hepatotoxicity associated with drugs and drug candidates has been attributed to existing gaps in our understanding of the mechanisms involved in driving hepatic injury after these compounds perfuse and are metabolized by the liver...
May 3, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29719507/breathomics-for-assessing-the-effects-of-treatment-and-withdrawal-with-inhaled-beclomethasone-formoterol-in-patients-with-copd
#11
Paolo Montuschi, Giuseppe Santini, Nadia Mores, Alessia Vignoli, Francesco Macagno, Rugia Shoreh, Leonardo Tenori, Gina Zini, Leonello Fuso, Chiara Mondino, Corrado Di Natale, Arnaldo D'Amico, Claudio Luchinat, Peter J Barnes, Tim Higenbottam
Background: Prospective pharmacological studies on breathomics profiles in COPD patients have not been previously reported. We assessed the effects of treatment and withdrawal of an extrafine inhaled corticosteroid (ICS)-long-acting β2 -agonist (LABA) fixed dose combination (FDC) using a multidimensional classification model including breathomics. Methods: A pilot, proof-of-concept, pharmacological study was undertaken in 14 COPD patients on maintenance treatment with inhaled fluticasone propionate/salmeterol (500/50 μg b...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29713111/estimating-environmental-co-benefits-of-u-s-low-carbon-pathways-using-an-integrated-assessment-model-with-state-level-resolution
#12
Yang Ou, Wenjing Shi, Steven J Smith, Catherine M Ledna, J Jason West, Christopher G Nolte, Daniel H Loughlin
There are many technological pathways that can lead to reduced carbon dioxide emissions. However, these pathways can have substantially different impacts on other environmental endpoints, such as air quality and energy-related water demand. This study uses an integrated assessment model with state-level resolution of the energy system to compare environmental impacts of alternative low-carbon pathways for the United States. One set of pathways emphasizes nuclear energy and carbon capture and storage, while another set emphasizes renewable energy, including wind, solar, geothermal power, and bioenergy...
April 15, 2018: Applied Energy
https://www.readbyqxmd.com/read/29706501/inducible-expression-of-gdnf-in-transplanted-ipsc-derived-neural-progenitor-cells
#13
Aslam Abbasi Akhtar, Genevieve Gowing, Naomi Kobritz, Steve E Savinoff, Leslie Garcia, David Saxon, Noell Cho, Gibum Kim, Colton M Tom, Hannah Park, George Lawless, Brandon C Shelley, Virginia B Mattis, Joshua J Breunig, Clive N Svendsen
Trophic factor delivery to the brain using stem cell-derived neural progenitors is a powerful way to bypass the blood-brain barrier. Protection of diseased neurons using this technology is a promising therapy for neurodegenerative diseases. Glial cell line-derived neurotrophic factor (GDNF) has provided benefits to Parkinsonian patients and is being used in a clinical trial for amyotrophic lateral sclerosis. However, chronic trophic factor delivery prohibits dose adjustment or cessation if side effects develop...
June 5, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29701167/amaze-a-double-blind-multicentre-randomised-controlled-trial-to-investigate-the-clinical-effectiveness-and-cost-effectiveness-of-adding-an-ablation-device-based-maze-procedure-as-an-adjunct-to-routine-cardiac-surgery-for-patients-with-pre-existing-atrial-fibrillation
#14
Linda Sharples, Colin Everett, Jeshika Singh, Christine Mills, Tom Spyt, Yasir Abu-Omar, Simon Fynn, Benjamin Thorpe, Victoria Stoneman, Hester Goddard, Julia Fox-Rushby, Samer Nashef
BACKGROUND: Atrial fibrillation (AF) can be treated using a maze procedure during planned cardiac surgery, but the effect on clinical patient outcomes, and the cost-effectiveness compared with surgery alone, are uncertain. OBJECTIVES: To determine whether or not the maze procedure is safe, improves clinical and patient outcomes and is cost-effective for the NHS in patients with AF. DESIGN: Multicentre, Phase III, pragmatic, double-blind, parallel-arm randomised controlled trial...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29685748/bed-ii-sequence-stratigraphic-context-of-ef-hr-and-hwk-ee-archaeological-sites-and-the-oldowan-acheulean-succession-at-olduvai-gorge-tanzania
#15
Ian G Stanistreet, Lindsay J McHenry, Harald Stollhofen, Ignacio de la Torre
Archaeological excavations at EF-HR and HWK EE allow reassessment of Bed II stratigraphy within the Junction Area and eastern Olduvai Gorge. Application of Sequence Stratigraphic methods provides a time-stratigraphic framework enabling correlation of sedimentary units across facies boundaries, applicable even in those areas where conventional timelines, such as tephrostratigraphic markers, are absent, eroded, or reworked. Sequence Stratigraphically, Bed II subdivides into five major Sequences 1 to 5, all floored by major disconformities that incise deeply into the underlying succession, proving that simple "layer cake" stratigraphy is inappropriate...
April 20, 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29682052/venous-air-embolism-during-endoscopic-third-ventriculostomy
#16
Renu Bala, Mihir P Pandia
Neuroendoscopic procedures are increasingly performed nowadays due to the significant technological improvement of endoscopic instrumentation. It carries various advantages such as speed, simplicity, avoidance of implants, and no brain dissection or retraction. Although considered to be safe, it is associated with a host of complications. We hereby report a case of venous air embolism in an infant who was undergoing endoscopic third ventriculostomy. The complication occurred at the completion of surgery when surgeons were withdrawing the endoscope...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29669554/a-g-o-type-opsin-mediates-the-shadow-reflex-in-the-annelid-platynereis-dumerilii
#17
Thomas Ayers, Hisao Tsukamoto, Martin Gühmann, Vinoth Babu Veedin Rajan, Kristin Tessmar-Raible
BACKGROUND: The presence of photoreceptive molecules outside the eye is widespread among animals, yet their functions in the periphery are less well understood. Marine organisms, such as annelid worms, exhibit a 'shadow reflex', a defensive withdrawal behaviour triggered by a decrease in illumination. Herein, we examine the cellular and molecular underpinnings of this response, identifying a role for a photoreceptor molecule of the Go -opsin class in the shadow response of the marine bristle worm Platynereis dumerilii...
April 18, 2018: BMC Biology
https://www.readbyqxmd.com/read/29656722/toward-a-contingency-model-for-hospital-based-health-technology-assessment-evidence-from-adhophta-project
#18
Americo Cicchetti, Valentina Iacopino, Silvia Coretti, Alessandra Fiore, Marco Marchetti, Laura Sampietro-Colom, Kristian Kidholm, Jean-Blaise Wasserfallen, Rabia Kahveci, Esa Halmesmäki, Magdalene Rosenmöller, Claudia Wild, Raul-Allan Kivet
OBJECTIVES: Hospital-based health technology assessment (HB-HTA) is becoming increasingly relevant because of its role in managing the introduction and withdrawal of health technologies. The organizational arrangement in which HB-HTA activities are conducted depends on several contextual factors, although the dominant models have several similarities. The aims of this study were to explore, describe, interpret, and explain seven cases of the application of HB-HTA logic and to propose a classification for HB-HTA organizational models which may be beneficial for policy makers and HTA professionals...
January 2018: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29608947/microencapsulated-schwann-cell-transplantation-inhibits-p2x2-3-receptors-overexpression-in-a-sciatic-nerve-injury-rat-model-with-neuropathic-pain
#19
Ya-Ling Zhang, Yi-Guo Liu, De-Jian Chen, Bao-Lin Yang, Tao-Tao Liu, Jia-Juan Li, Xiu-Qi Wang, Hao-Tian Rose Li, Zeng-Xu Liu
Transplantation of Schwann cells (SCs) can promote axonal regeneration and formation of the myelin sheath, reduce inflammation, and promote repair to the damaged nerve. Our previous studies have shown that transplantation of free or micro-encapsulated olfactory ensheathing cells can relieve neuropathic pain. There are no related reports regarding whether the transplantation of micro-encapsulated SCs can alleviate neuropathic pain mediated by P2X2/3 receptors. In the present study, we micro-encapsulated SCs in alginic acid and transplanted them into the region surrounding the injured sciatic nerve in the rat model of chronic constriction injury (CCI)...
May 29, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29603595/integrated-technological-and-management-solutions-for-wastewater-treatment-and-efficient-agricultural-reuse-in-egypt-morocco-and-tunisia
#20
Dario Frascari, Giulio Zanaroli, Mohamed Abdel Motaleb, Giorgio Annen, Khaoula Belguith, Sara Borin, Redouane Choukr-Allah, Catherine Gibert, Atef Jaouani, Nicolas Kalogerakis, Fawzi Karajeh, Philippe A Ker Rault, Roula Khadra, Stathis Kyriacou, Wen-Tao Li, Bruno Molle, Marijn Mulder, Emmanuel Oertlé, Consuelo Varela Ortega
Mediterranean-African countries (MACs) face a major water crisis. The annual renewable water resources are close to the 500 m3 /capita threshold of absolute water scarcity, and water withdrawals exceed total renewable water resources by 30%. Such a low water availability curbs economic development in agriculture, which accounts for 86% of freshwater consumption. The analysis of the current situation of wastewater treatment, irrigation, and water management in MACs and of the research projects targeted to these countries indicates the need for 1) an enhanced capacity to analyze water stress, 2) the development of water management strategies capable of including wastewater reuse, and 3) development of locally adapted water treatment and irrigation technologies...
March 30, 2018: Integrated Environmental Assessment and Management
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