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Ribose AND glycation

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https://www.readbyqxmd.com/read/29043349/comparative-suppressing-effects-of-black-and-green-teas-on-the-formation-of-advanced-glycation-end-products-ages-and-age-induced-oxidative-stress
#1
P Ramlagan, P Rondeau, C Planesse, V S Neergheen-Bhujun, E Bourdon, T Bahorun
This study aimed at investigating and comparing the anti-diabetic potential of black and green teas. Biochemical analyses indicate higher antioxidant potency, significantly correlated with the phytochemicals present, in green teas compared to black teas. Both extracts afforded a similar level of protection to erythrocytes against peroxyl radical-induced lysis. Non-cytotoxic concentration of green and black tea extracts significantly reduced the reactive oxygen species (ROS) production (P < 0.01), lowered the oxidation of proteins (P < 0...
October 18, 2017: Food & Function
https://www.readbyqxmd.com/read/29038915/glycation-of-lys-16-and-arg-5-in-amyloid-%C3%AE-and-the-presence-of-cu-2-play-a-major-role-in-the-oxidative-stress-mechanism-of-alzheimer-s-disease
#2
Sebastian M Fica-Contreras, Sydney O Shuster, Nathaniel D Durfee, Gregory J K Bowe, Nathaniel J Henning, Staci A Hill, Geoffrey D Vrla, David R Stillman, Kelly M Suralik, Roger K Sandwick, Sunhee Choi
Extensive research has linked the amyloid-beta (Aβ) peptide to neurological dysfunction in Alzheimer's disease (AD). Insoluble Aβ plaques in the AD patient brain contain high concentrations of advanced glycation end-products (AGEs) as well as transition metal ions. This research elucidated the roles of Aβ, sugars, and Cu(2+) in the oxidative stress mechanism of AD at the molecular level. Mass spectral (MS) analysis of the reactions of Aβ with two representative sugars, ribose-5-phosphate (R5P) and methylglyoxal (MG), revealed Lys-16 and Arg-5 as the primary glycation sites...
December 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29033370/d-ribose-as-a-contributor-to-glycated-haemoglobin
#3
Xixi Chen, Tao Su, Yao Chen, Yingge He, Ying Liu, Yong Xu, Yan Wei, Juan Li, Rongqiao He
Glycated haemoglobin (HbA1c) is the most important marker of hyperglycaemia in diabetes mellitus. We show that d-ribose reacts with haemoglobin, thus yielding HbA1c. Using mass spectrometry, we detected glycation of haemoglobin with d-ribose produces 10 carboxylmethyllysines (CMLs). The first-order rate constant of fructosamine formation for d-ribose was approximately 60 times higher than that for d-glucose at the initial stage. Zucker Diabetic Fatty (ZDF) rat, a common model for type 2 diabetes mellitus (T2DM), had high levels of d-ribose and HbA1c, accompanied by a decrease of transketolase (TK) in the liver...
October 5, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28886871/daf-in-diabetic-patients-is-subject-to-glycation-inactivation-at-its-active-site-residues
#4
Rudolf Flückiger, Enzo Cocuzzi, Ram H Nagaraj, Menachem Shoham, Timothy S Kern, M Edward Medof
Decay accelerating factor (DAF or CD55) is a cell associated C3 and C5 convertase regulator originally described in terms of protection of self-cells from systemic complement but now known to modulate adaptive T cell responses. It is expressed on all cell types. We investigated whether nonenzymatic glycation could impair its function and potentially be relevant to complications of diabetes mellitus and other conditions that result in nonenzymatic glycation including cancer, Alzheimer's disease, and aging. Immunoblots of affinity-purified DAF from erythrocytes of patients with diabetes showed pentosidine, glyoxal-AGEs, carboxymethyllysine, and argpyrimidine...
September 5, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28873750/artichoke-cynara-cardunculus-l-var-scolymus-waste-as-a-natural-source-of-carbonyl-trapping-and-antiglycative-agents
#5
Mariarosa Maietta, Raffaella Colombo, Roberto Lavecchia, Milena Sorrenti, Antonio Zuorro, Adele Papetti
The role of polyphenolic compounds extractable from artichoke solid wastes in the formation of advanced glycation end products (AGEs) was studied. Outer bracts and stems were extracted using different water-ethanol mixtures and HPLC-DAD analyses indicated aqueous and hydro-alcoholic 20:80 stem extracts as the richest in polyphenols. The samples were characterized in their phenolic composition (using mass spectrometry) and antioxidant capacity. Antiglycative capacity was evaluated by in vitro BSA-sugars (glucose, fructose, and ribose) and BSA-methylglyoxal (MGO) tests, formation of Amadori products assay, direct glyoxal (GO) and MGO trapping capacity...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28862361/accumulation-of-advanced-glycation-end-products-ages-accelerates-arthrogenic-joint-contracture-in-immobilized-rat-knee
#6
Junya Ozawa, Akinori Kaneguchi, Kengo Minamimoto, Ryo Tanaka, Nobuhiro Kito, Hideki Moriyama
Joint mobility decreases in the elderly and in diabetics, this process is thought to be caused by accumulation of advanced-glycation end products (AGEs). Here, we aimed to elucidate the role of AGEs in joint contracture formation in rat knees. Rats were injected with ribose or saline into the knees twice weekly for eight weeks. Pentosidine (AGE) levels were measured in the knee-joint tissues. After serial injections, rats were subjected to unilateral knee-joint immobilization in a flexion position for various periods...
September 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28843673/glycation-induced-conformational-alterations-in-caprine-brain-cystatin-cbc-leads-to-aggregation-via-passage-through-a-partially-folded-state
#7
Peerzada Shariq Shaheen Khaki, Anna Feroz, Azad Alam Siddiqui, Syed Mudasir Qadri, Fakhra Amin, Bilqees Bano
Glycation induced advanced glycation end products (AGEs) of proteins formed as a result of Maillard reaction is currently at the heart of a number of pathological conditions. The formation of chemically stable AGEs can permanently alter protein structure and function; hence can serve as an implication in long term complications. Cystatins with high amyloidogenic inclination are implicated in various diseases including cancer and neurodegenerative conditions. The aggregates of cystatin purified from caprine brain have been studied on addition of glucose and ribose using UV absorption, fluorescence emission, circular dichroism (CD) spectroscopy and transmission electron microscopy (TEM)...
August 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28755585/evaluation-of-asteraceae-herbal-extracts-in-the-management-of-diabetes-and-obesity-contribution-of-caffeoylquinic-acids-on-the-inhibition-of-digestive-enzymes-activity-and-formation-of-advanced-glycation-end-products-in%C3%A2-vitro
#8
Vítor Spínola, Paula C Castilho
The study was performed to assess, for the first time, the in vitro anti-diabetic potential of ten Asteraceae plant extracts to inhibit the activity of digestive enzymes (α-amylase, α-, β-glucosidases and lipase) responsible for hydrolysis/digestion of sugar and lipids. Prevention of advanced glycation end-products (AGEs) formation was evaluated in bovine serum albumin/ribose glycation reaction model. The phytochemical profiles and caffeoylquinic acids (CQAs) contents were determined for the methanolic extract of each plant...
November 2017: Phytochemistry
https://www.readbyqxmd.com/read/28713809/a-perspective-on-reagent-diversity-and-non-covalent-binding-of-reactive-carbonyl-species-rcs-and-effector-reagents-in-non-enzymatic-glycation-neg-mechanistic-considerations-and-implications-for-future-research
#9
Kenneth J Rodnick, R W Holman, Pamela S Ropski, Mingdong Huang, Arthur L M Swislocki
This perspective focuses on illustrating the underappreciated connections between reactive carbonyl species (RCS), initial binding in the nonenzymatic glycation (NEG) process, and nonenzymatic covalent protein modification (here termed NECPM). While glucose is the central species involved in NEG, recent studies indicate that the initially-bound glucose species in the NEG of human hemoglobin (HbA) and human serum albumin (HSA) are non-RCS ring-closed isomers. The ring-opened glucose, an RCS structure that reacts in the NEG process, is most likely generated from previously-bound ring-closed isomers undergoing concerted acid/base reactions while bound to protein...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28573980/3d-porous-collagen-scaffolds-reinforced-by-glycation-with-ribose-for-tissue-engineering-application
#10
Natalia Gostynska, Gopal Shankar Krishnakumar, Elisabetta Campodoni, Silvia Panseri, Monica Montesi, Simone Sprio, Elizaveta Kon, Maurilio Marcacci, Anna Tampieri, Monica Sandri
In this study, ribose was proposed as a promising, non-toxic, low-cost crosslinker to enhance the structural integrity and stiffness of type I collagen matrices. The main objective was to determine the optimal conditions of glycation by ribose to fabricate 3D porous collagen scaffolds and to verify their effectiveness for use as scaffolds for cartilage tissue engineering, by physicochemical and biological characterization. Two different crosslinking strategies were investigated including variation in the amount of ribose and the time of reaction: pre-crosslinking (PRE) and post-crosslinking (POST)...
August 21, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28532070/ribose-mediated-crosslinking-of-collagen-hydroxyapatite-hybrid-scaffolds-for-bone-tissue-regeneration-using-biomimetic-strategies
#11
Gopal Shankar Krishnakumar, Natalia Gostynska, Elisabetta Campodoni, Massimiliano Dapporto, Monica Montesi, Silvia Panseri, Anna Tampieri, Elizaveta Kon, Maurilio Marcacci, Simone Sprio, Monica Sandri
This study explores for the first time the application of ribose as a highly biocompatible agent for the crosslinking of hybrid mineralized constructs, obtained by bio-inspired mineralization of self-assembling Type I collagen matrix with magnesium-doped-hydroxyapatite nanophase, towards a biomimetic mineralized 3D scaffolds (MgHA/Coll) with excellent compositional and structural mimicry of bone tissue. To this aim, two different crosslinking mechanisms in terms of pre-ribose glycation (before freeze drying) and post-ribose glycation (after freeze drying) were investigated...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28388357/quercetin-inhibits-advanced-glycation-end-product-formation-via-chelating-metal-ions-trapping-methylglyoxal-and-trapping-reactive-oxygen-species
#12
Mohammad Nazrul Islam Bhuiyan, Shinya Mitsuhashi, Kengo Sigetomi, Makoto Ubukata
Physiological concentration of Mg(2+), Cu(2+), and Zn(2+) accelerated AGE formation only in glucose-mediated conditions, which was effectively inhibited by chelating ligands. Only quercetin (10) inhibited MGO-mediated AGE formation as well as glucose- and ribose-mediated AGE formation among 10 polyphenols (1-10) tested. We performed an additional structure-activity relationship (SAR) study on flavanols (10, 11, 12, 13, and 14). Morin (12) and kaempherol (14) showed inhibitory activity against MGO-mediated AGE formation, whereas rutin (11) and fisetin (13) did not...
May 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28375088/effect-of-viscum-schimperi-on-advanced-glycation-endproducts-formation
#13
Hossam Mohamed Abdallah, Doha Omar ALGhamdi, Maab Siddiq Al-Salem, Maryam Alattas, Hany Mohamed El-Bassossy, Abdulrahman Mohammed Alahdal
Diabetes is a disease characterized by elevated uncontrolled glucose level. Hyperglycemia results in diabetic complication due to a reaction between sugar and amino acid of proteins to form advanced glycation endproducts (AGEs) in different tissues. Medicinal plants are considered as a great source of bioactive compounds that affect many ailments. In this regard; AGEs formation could be inhibited by many bioactive compounds isolated from medicinal plants. Viscum schimperi Engl. is a plant belongs to Loranthaceae and known for its antidiabetic activity...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28257177/glycation-of-lysozyme-by-glycolaldehyde-provides-new-mechanistic-insights-in-diabetes-related-protein-aggregation
#14
Laura Mariño, Carlos Andrés Maya-Aguirre, Kris Pauwels, Bartolomé Vilanova, Joaquin Ortega-Castro, Juan Frau, Josefa Donoso, Miquel Adrover
Glycation occurs in vivo as a result of the nonenzymatic reaction of carbohydrates (and/or their autoxidation products) with proteins, DNA, or lipids. Protein glycation causes loss-of-function and, consequently, the development of diabetic-related diseases. Glycation also boosts protein aggregation, which can be directly related with the higher prevalence of aggregating diseases in diabetic people. However, the molecular mechanism connecting glycation with aggregation still remains unclear. Previously we described mechanistically how glycation of hen egg-white lysozyme (HEWL) with ribose induced its aggregation...
April 21, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28167471/effect-of-viscum-schimperi-on-advanced-glycation-endproducts-formation
#15
Hossam Mohamed Abdallah, Doha Omar ALGhamdi, Maab Siddiq Al-Salem, Maryam Alattas, Hany Mohamed El-Bassossy, Abdulrahman Mohammed Alahdal, Ibrahim Ateya Shehata, Essam Abdel-Sattar
Diabetes is a disease characterized by elevated uncontrolled glucose level. Hyperglycemia results in diabetic complication due to a reaction between sugar and amino acid of proteins to form advanced glycation endproducts (AGEs) in different tissues. Medicinal plants are considered as a great source of bioactive compounds that affect many ailments. In this regard; AGEs formation could be inhibited by many bioactive compounds isolated from medicinal plants. Viscum schimperi Engl. is a plant belongs to Loranthaceae and known for its antidiabetic activity...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28130827/advanced-glycation-end-products-stimulate-gene-expression-of-fibroblast-growth-factor-23
#16
Ludmilla Bär, Kristin Wächter, Nicole Wege, Alexander Navarrete Santos, Andreas Simm, Michael Föller
SCOPE: Osteoblasts produce fibroblast growth factor 23 (FGF23), a hormone inhibiting renal phosphate reabsorption and the formation of biologically active vitamin D, calcitriol. FGF23-deficient mice age rapidly and develop age-associated diseases at least in part due to massive calcification. Elevated FGF23 serum levels are detected in patients suffering from acute and chronic renal, cardiovascular, inflammatory, and metabolic diseases. Advanced glycation end products (AGEs) are sugar-modified proteins, nucleic acid, and lipids which contribute to these disorders...
August 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28109917/assessment-of-collagen-quality-associated-with-non-enzymatic-cross-links-in-human-bone-using-fourier-transform-infrared-imaging
#17
F N Schmidt, E A Zimmermann, G M Campbell, G E Sroga, K Püschel, M Amling, S Y Tang, D Vashishth, B Busse
Aging and many disease conditions, most notably diabetes, are associated with the accumulation of non-enzymatic cross-links in the bone matrix. The non-enzymatic cross-links, also known as advanced glycation end products (AGEs), occur at the collagen tissue level, where they are associated with reduced plasticity and increased fracture risk. In this study, Fourier-transform infrared (FTIR) imaging was used to detect spectroscopic changes associated with the formation of non-enzymatic cross-links in human bone collagen...
April 2017: Bone
https://www.readbyqxmd.com/read/28051097/aged-garlic-has-more-potent-antiglycation-and-antioxidant-properties-compared-to-fresh-garlic-extract-in-vitro
#18
Abdulhakim Elosta, Mark Slevin, Khalid Rahman, Nessar Ahmed
Protein glycation involves formation of early (Amadori) and late advanced glycation endproducts (AGEs) together with free radicals via autoxidation of glucose and Amadori products. Glycation and increased free radical activity underlie the pathogenesis of diabetic complications. This study investigated whether aged garlic has more potent antiglycation and antioxidant properties compared to fresh garlic extract in vitro in a cell-free system. Proteins were glycated by incubation with sugars (glucose, methylglyoxal or ribose) ±5-15 mg/mL of aged and fresh garlic extracts...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27979189/improved-physicochemical-properties-and-hepatic-protection-of-maillard-reaction-products-derived-from-fish-protein-hydrolysates-and-ribose
#19
Sung-Yong Yang, Sanghoon Lee, Min Cheol Pyo, Hyeonjin Jeon, Yoonsook Kim, Kwang-Won Lee
High amounts of waste products generated from fish-processing need to be disposed of despite their potential nutritional value. A variety of methods, such as enzymatic hydrolysis, have been developed for these byproducts. In the current study, we investigated the physicochemical, biological and antioxidative properties of fish protein hydrolysates (FPH) conjugated with ribose through the Maillard reaction. These glycated conjugates of FPH (GFPH) had more viscous rheological properties than FPH and exhibited higher heat, emulsification and foaming stability...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27917671/-the-role-of-oxidative-stress-in-the-development-of-diabetic-neuropathy
#20
REVIEW
Ferenc Sztanek, Ágnes Molnárné Molnár, Zoltán Balogh
Diabetic neuropathy may be one of the most common and severe complications of diabetes mellitus. Oxidative stress plays a pivotal role in the development of microvascular complications of diabetes. The majority of related pathways like polyol and hexosamine, advanced glycation end products, poly-ADP-ribose polymerase, and protein kinase-C all originated from initial oxidative stress. In this review, the authors present the current oxidative stress hypothesis in diabetes mellitus and summarize the pathophysiological mechanisms of diabetic neuropathy associated with increased oxidative stress...
December 2016: Orvosi Hetilap
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