keyword
MENU ▼
Read by QxMD icon Read
search

Ribose AND glycation

keyword
https://www.readbyqxmd.com/read/28755585/evaluation-of-asteraceae-herbal-extracts-in-the-management-of-diabetes-and-obesity-contribution-of-caffeoylquinic-acids-on-the-inhibition-of-digestive-enzymes-activity-and-formation-of-advanced-glycation-end-products-in%C3%A2-vitro
#1
Vítor Spínola, Paula C Castilho
The study was performed to assess, for the first time, the in vitro anti-diabetic potential of ten Asteraceae plant extracts to inhibit the activity of digestive enzymes (α-amylase, α-, β-glucosidases and lipase) responsible for hydrolysis/digestion of sugar and lipids. Prevention of advanced glycation end-products (AGEs) formation was evaluated in bovine serum albumin/ribose glycation reaction model. The phytochemical profiles and caffeoylquinic acids (CQAs) contents were determined for the methanolic extract of each plant...
July 26, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28713809/a-perspective-on-reagent-diversity-and-non-covalent-binding-of-reactive-carbonyl-species-rcs-and-effector-reagents-in-non-enzymatic-glycation-neg-mechanistic-considerations-and-implications-for-future-research
#2
Kenneth J Rodnick, R W Holman, Pamela S Ropski, Mingdong Huang, Arthur L M Swislocki
This perspective focuses on illustrating the underappreciated connections between reactive carbonyl species (RCS), initial binding in the nonenzymatic glycation (NEG) process, and nonenzymatic covalent protein modification (here termed NECPM). While glucose is the central species involved in NEG, recent studies indicate that the initially-bound glucose species in the NEG of human hemoglobin (HbA) and human serum albumin (HSA) are non-RCS ring-closed isomers. The ring-opened glucose, an RCS structure that reacts in the NEG process, is most likely generated from previously-bound ring-closed isomers undergoing concerted acid/base reactions while bound to protein...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28573980/3d-porous-collagen-scaffolds-reinforced-by-glycation-with-ribose-for-tissue-engineering-application
#3
Natalia Gostynska, Gopal Krishnakumar, Elisabetta Campodoni, Silvia Panseri, Monica Montesi, Simone Sprio, Elizaveta Kon, Maurilio Marcacci, Anna Tampieri, Monica Sandri
In this study ribose was proposed as a promising, non-toxic, low-cost crosslinker to enhance the structural integrity and stiffness of type I collagen matrices. The main objective was to determine optimal conditions of glycation by ribose to fabricate 3D porous collagen scaffolds and to verify their effectiveness for use as scaffolds for cartilage tissue engineering (TE), by physicochemical and biological characterization. Two different crosslinking strategies were investigated including variety in the amount of ribose and the time of reaction: pre-crosslinking (PRE) and post-crosslinking (POST)...
June 2, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28532070/ribose-mediated-crosslinking-of-collagen-hydroxyapatite-hybrid-scaffolds-for-bone-tissue-regeneration-using-biomimetic-strategies
#4
Gopal Shankar Krishnakumar, Natalia Gostynska, Elisabetta Campodoni, Massimiliano Dapporto, Monica Montesi, Silvia Panseri, Anna Tampieri, Elizaveta Kon, Maurilio Marcacci, Simone Sprio, Monica Sandri
This study explores for the first time the application of ribose as a highly biocompatible agent for the crosslinking of hybrid mineralized constructs, obtained by bio-inspired mineralization of self-assembling Type I collagen matrix with magnesium-doped-hydroxyapatite nanophase, towards a biomimetic mineralized 3D scaffolds (MgHA/Coll) with excellent compositional and structural mimicry of bone tissue. To this aim, two different crosslinking mechanisms in terms of pre-ribose glycation (before freeze drying) and post-ribose glycation (after freeze drying) were investigated...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28388357/quercetin-inhibits-advanced-glycation-end-product-formation-via-chelating-metal-ions-trapping-methylglyoxal-and-trapping-reactive-oxygen-species
#5
Mohammad Nazrul Islam Bhuiyan, Shinya Mitsuhashi, Kengo Sigetomi, Makoto Ubukata
Physiological concentration of Mg(2+), Cu(2+), and Zn(2+) accelerated AGE formation only in glucose-mediated conditions, which was effectively inhibited by chelating ligands. Only quercetin (10) inhibited MGO-mediated AGE formation as well as glucose- and ribose-mediated AGE formation among 10 polyphenols (1-10) tested. We performed an additional structure-activity relationship (SAR) study on flavanols (10, 11, 12, 13, and 14). Morin (12) and kaempherol (14) showed inhibitory activity against MGO-mediated AGE formation, whereas rutin (11) and fisetin (13) did not...
May 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28375088/effect-of-viscum-schimperi-on-advanced-glycation-endproducts-formation
#6
Hossam Mohamed Abdallah, Doha Omar ALGhamdi, Maab Siddiq Al-Salem, Maryam Alattas, Hany Mohamed El-Bassossy, Abdulrahman Mohammed Alahdal
Diabetes is a disease characterized by elevated uncontrolled glucose level. Hyperglycemia results in diabetic complication due to a reaction between sugar and amino acid of proteins to form advanced glycation endproducts (AGEs) in different tissues. Medicinal plants are considered as a great source of bioactive compounds that affect many ailments. In this regard; AGEs formation could be inhibited by many bioactive compounds isolated from medicinal plants. Viscum schimperi Engl. is a plant belongs to Loranthaceae and known for its antidiabetic activity...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28257177/glycation-of-lysozyme-by-glycolaldehyde-provides-new-mechanistic-insights-in-diabetes-related-protein-aggregation
#7
Laura Mariño, Carlos Andrés Maya-Aguirre, Kris Pauwels, Bartolomé Vilanova, Joaquin Ortega-Castro, Juan Frau, Josefa Donoso, Miquel Adrover
Glycation occurs in vivo as a result of the nonenzymatic reaction of carbohydrates (and/or their autoxidation products) with proteins, DNA, or lipids. Protein glycation causes loss-of-function and, consequently, the development of diabetic-related diseases. Glycation also boosts protein aggregation, which can be directly related with the higher prevalence of aggregating diseases in diabetic people. However, the molecular mechanism connecting glycation with aggregation still remains unclear. Previously we described mechanistically how glycation of hen egg-white lysozyme (HEWL) with ribose induced its aggregation...
April 21, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28167471/effect-of-viscum-schimperi-on-advanced-glycation-endproducts-formation
#8
Hossam Mohamed Abdallah, Doha Omar ALGhamdi, Maab Siddiq Al-Salem, Maryam Alattas, Hany Mohamed El-Bassossy, Abdulrahman Mohammed Alahdal, Ibrahim Ateya Shehata, Essam Abdel-Sattar
Diabetes is a disease characterized by elevated uncontrolled glucose level. Hyperglycemia results in diabetic complication due to a reaction between sugar and amino acid of proteins to form advanced glycation endproducts (AGEs) in different tissues. Medicinal plants are considered as a great source of bioactive compounds that affect many ailments. In this regard; AGEs formation could be inhibited by many bioactive compounds isolated from medicinal plants. Viscum schimperi Engl. is a plant belongs to Loranthaceae and known for its antidiabetic activity...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28130827/advanced-glycation-end-products-stimulate-gene-expression-of-fibroblast-growth-factor-23
#9
Ludmilla Bär, Kristin Wächter, Nicole Wege, Alexander Navarrete Santos, Andreas Simm, Michael Föller
SCOPE: Osteoblasts produce fibroblast growth factor 23 (FGF23), a hormone inhibiting renal phosphate reabsorption and the formation of biologically active vitamin D, calcitriol. FGF23-deficient mice age rapidly and develop age-associated diseases at least in part due to massive calcification. Elevated FGF23 serum levels are detected in patients suffering from acute and chronic renal, cardiovascular, inflammatory, and metabolic diseases. Advanced glycation end products (AGEs) are sugar-modified proteins, nucleic acid, and lipids which contribute to these disorders...
January 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28109917/assessment-of-collagen-quality-associated-with-non-enzymatic-cross-links-in-human-bone-using-fourier-transform-infrared-imaging
#10
F N Schmidt, E A Zimmermann, G M Campbell, G E Sroga, K Püschel, M Amling, S Y Tang, D Vashishth, B Busse
Aging and many disease conditions, most notably diabetes, are associated with the accumulation of non-enzymatic cross-links in the bone matrix. The non-enzymatic cross-links, also known as advanced glycation end products (AGEs), occur at the collagen tissue level, where they are associated with reduced plasticity and increased fracture risk. In this study, Fourier-transform infrared (FTIR) imaging was used to detect spectroscopic changes associated with the formation of non-enzymatic cross-links in human bone collagen...
April 2017: Bone
https://www.readbyqxmd.com/read/28051097/aged-garlic-has-more-potent-antiglycation-and-antioxidant-properties-compared-to-fresh-garlic-extract-in-vitro
#11
Abdulhakim Elosta, Mark Slevin, Khalid Rahman, Nessar Ahmed
Protein glycation involves formation of early (Amadori) and late advanced glycation endproducts (AGEs) together with free radicals via autoxidation of glucose and Amadori products. Glycation and increased free radical activity underlie the pathogenesis of diabetic complications. This study investigated whether aged garlic has more potent antiglycation and antioxidant properties compared to fresh garlic extract in vitro in a cell-free system. Proteins were glycated by incubation with sugars (glucose, methylglyoxal or ribose) ±5-15 mg/mL of aged and fresh garlic extracts...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27979189/improved-physicochemical-properties-and-hepatic-protection-of-maillard-reaction-products-derived-from-fish-protein-hydrolysates-and-ribose
#12
Sung-Yong Yang, Sanghoon Lee, Min Cheol Pyo, Hyeonjin Jeon, Yoonsook Kim, Kwang-Won Lee
High amounts of waste products generated from fish-processing need to be disposed of despite their potential nutritional value. A variety of methods, such as enzymatic hydrolysis, have been developed for these byproducts. In the current study, we investigated the physicochemical, biological and antioxidative properties of fish protein hydrolysates (FPH) conjugated with ribose through the Maillard reaction. These glycated conjugates of FPH (GFPH) had more viscous rheological properties than FPH and exhibited higher heat, emulsification and foaming stability...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27917671/-the-role-of-oxidative-stress-in-the-development-of-diabetic-neuropathy
#13
REVIEW
Ferenc Sztanek, Ágnes Molnárné Molnár, Zoltán Balogh
Diabetic neuropathy may be one of the most common and severe complications of diabetes mellitus. Oxidative stress plays a pivotal role in the development of microvascular complications of diabetes. The majority of related pathways like polyol and hexosamine, advanced glycation end products, poly-ADP-ribose polymerase, and protein kinase-C all originated from initial oxidative stress. In this review, the authors present the current oxidative stress hypothesis in diabetes mellitus and summarize the pathophysiological mechanisms of diabetic neuropathy associated with increased oxidative stress...
December 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27822918/ferulic-acid-prevents-methylglyoxal-induced-protein-glycation-dna-damage-and-apoptosis-in-pancreatic-%C3%AE-cells
#14
Weerachat Sompong, Henrique Cheng, Sirichai Adisakwattana
Methylglyoxal (MG) can react with amino acids of proteins to induce protein glycation and consequently the formation of advanced glycation end-products (AGEs). Previous studies reported that ferulic acid (FA) prevented glucose-, fructose-, and ribose-induced protein glycation. In this study, FA (0.1-1 mM) inhibited MG-induced protein glycation and oxidative protein damage in bovine serum albumin (BSA). Furthermore, FA (0.0125-0.2 mM) protected against lysine/MG-mediated oxidative DNA damage, thereby inhibiting superoxide anion and hydroxyl radical generation during lysine and MG reaction...
February 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27738860/mangostanaxanthones-iii-and-iv-advanced-glycation-end-product-inhibitors-from-the-pericarp-of-garcinia-mangostana
#15
Hossam M Abdallah, Hany M El-Bassossy, Gamal A Mohamed, Ali M El-Halawany, Khalid Z Alshali, Zainy M Banjar
Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a sugar during hyperglycemia. The precipitation of AGEs in different tissues leads to many complications, such as endothelial dysfunction, cardiovascular complications, atherosclerosis, retinopathy, neuropathy, and Alzheimer's disease. Garcinia mangostana L. (Clusiaceae) (GM) was selected owing to the ability of its polar and non-polar fractions to inhibit AGE formation...
January 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27695694/glycation-in-demetalated-superoxide-dismutase-1-prevents-amyloid-aggregation-and-produces-cytotoxic-ages-adducts
#16
Ivana Sirangelo, Filomena M Vella, Gaetano Irace, Giuseppe Manco, Clara Iannuzzi
Superoxide dismutase 1 (SOD1) has been implicated with familial amyotrophic lateral sclerosis (fALS) through accumulation of protein amyloid aggregates in motor neurons of patients. Amyloid aggregates and protein inclusions are a common pathological feature of many neurological disorders in which protein aggregation seems to be directly related to neurotoxicity. Although, extensive studies performed on the aggregation process of several amyloidogenic proteins in vitro allowed the identification of many physiological factors involved, the molecular mechanisms underlying the formation of amyloid aggregates in vivo and in pathological conditions are still poorly understood...
2016: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/27616134/advanced-glycation-end-products-mechanics-of-aged-collagen-from-molecule-to-tissue
#17
Alfonso Gautieri, Fabian S Passini, Unai Silván, Manuel Guizar-Sicairos, Giulia Carimati, Piero Volpi, Matteo Moretti, Herbert Schoenhuber, Alberto Redaelli, Martin Berli, Jess G Snedeker
Concurrent with a progressive loss of regenerative capacity, connective tissue aging is characterized by a progressive accumulation of Advanced Glycation End-products (AGEs). Besides being part of the typical aging process, type II diabetics are particularly affected by AGE accumulation due to abnormally high levels of systemic glucose that increases the glycation rate of long-lived proteins such as collagen. Although AGEs are associated with a wide range of clinical disorders, the mechanisms by which AGEs contribute to connective tissue disease in aging and diabetes are still poorly understood...
September 9, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27561427/detection-of-circulating-auto-antibodies-against-ribosylated-ldl-in-diabetes-patients
#18
Firoz Akhter, M Salman Khan, Mohammad Faisal, Abdulrahman A Alatar, Saheem Ahmad
BACKGROUND: This study analyzes effect of glycation on ApoB-100 residues by D-ribose as D-ribosylated-glycated LDL might be responsible for the cause of diabetes mellitus because of its far higher antigenic ability. The binding characteristics of circulating auto-antibodies in type 1 and type 2 diabetes patients against native and modified LDL were assessed. METHODS: T1 Diabetes (n = 43), T2 diabetes patients (n = 100) were examined by direct binding ELISA as well as inhibition ELISA, were compared with healthy age-matched controls (n = 50)...
March 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27526342/characterizing-harmful-advanced-glycation-end-products-ages-and-ribosylated-aggregates-of-yellow-mustard-seed-phytocystatin-effects-of-different-monosaccharides
#19
Azaj Ahmed, Anas Shamsi, Bilqees Bano
Advanced glycation end products (AGEs) are at the core of variety of diseases ranging from diabetes to renal failure and hence gaining wide consideration. This study was aimed at characterizing the AGEs of phytocystatin isolated from mustard seeds (YMP) when incubated with different monosaccharides (glucose, ribose and mannose) using fluorescence, ultraviolet, circular dichroism (CD) spectroscopy and microscopy. Ribose was found to be the most potent glycating agent as evident by AGEs specific fluorescence and absorbance...
January 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27454862/autoantibodies-to-post-translationally-modified-type-i-and-ii-collagen-in-charcot-neuroarthropathy-in-subjects-with-type-2-diabetes-mellitus
#20
Paola Rizzo, Dario Pitocco, Francesco Zaccardi, Enrico Di Stasio, Rocky Strollo, Alessandro Rizzi, Giuseppe Scavone, Federica Costantini, Marco Galli, Giovanni Tinelli, Andrea Flex, Salvatore Caputo, Paolo Pozzilli, Raffaele Landolfi, Giovanni Ghirlanda, Ahuva Nissim
AIMS: Charcot neuroarthropathy (CN) is a disabling complication, culminating in bone destruction and involving joints and articular cartilage with high inflammatory environment. Its real pathogenesis is as yet unknown. In autoinflammatory diseases, such as rheumatoid arthritis, characterized by inflammation and joint involvement, autoantibodies against oxidative post-translationally modified (oxPTM) collagen type I (CI) and type II (CII) were detected. Therefore, the aim of our study was to assess the potential involvement of autoimmunity in charcot neuroarthropathy, investigating the presence of autoantibodies oxPTM-CI and oxPTM-CII, in participants with charcot neuroarthropathy...
July 25, 2016: Diabetes/metabolism Research and Reviews
keyword
keyword
80546
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"