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Ribose AND glycation

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https://www.readbyqxmd.com/read/27822918/ferulic-acid-prevents-methylglyoxal-induced-protein-glycation-dna-damage-and-apoptosis-in-pancreatic-%C3%AE-cells
#1
Weerachat Sompong, Henrique Cheng, Sirichai Adisakwattana
Methylglyoxal (MG) can react with amino acids of proteins to induce protein glycation and consequently the formation of advanced glycation end-products (AGEs). Previous studies reported that ferulic acid (FA) prevented glucose-, fructose-, and ribose-induced protein glycation. In this study, FA (0.1-1 mM) inhibited MG-induced protein glycation and oxidative protein damage in bovine serum albumin (BSA). Furthermore, FA (0.0125-0.2 mM) protected against lysine/MG-mediated oxidative DNA damage, thereby inhibiting superoxide anion and hydroxyl radical generation during lysine and MG reaction...
November 7, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27738860/mangostanaxanthones-iii-and-iv-advanced-glycation-end-product-inhibitors-from-the-pericarp-of-garcinia-mangostana
#2
Hossam M Abdallah, Hany M El-Bassossy, Gamal A Mohamed, Ali M El-Halawany, Khalid Z Alshali, Zainy M Banjar
Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a sugar during hyperglycemia. The precipitation of AGEs in different tissues leads to many complications, such as endothelial dysfunction, cardiovascular complications, atherosclerosis, retinopathy, neuropathy, and Alzheimer's disease. Garcinia mangostana L. (Clusiaceae) (GM) was selected owing to the ability of its polar and non-polar fractions to inhibit AGE formation...
October 13, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27695694/glycation-in-demetalated-superoxide-dismutase-1-prevents-amyloid-aggregation-and-produces-cytotoxic-ages-adducts
#3
Ivana Sirangelo, Filomena M Vella, Gaetano Irace, Giuseppe Manco, Clara Iannuzzi
Superoxide dismutase 1 (SOD1) has been implicated with familial amyotrophic lateral sclerosis (fALS) through accumulation of protein amyloid aggregates in motor neurons of patients. Amyloid aggregates and protein inclusions are a common pathological feature of many neurological disorders in which protein aggregation seems to be directly related to neurotoxicity. Although, extensive studies performed on the aggregation process of several amyloidogenic proteins in vitro allowed the identification of many physiological factors involved, the molecular mechanisms underlying the formation of amyloid aggregates in vivo and in pathological conditions are still poorly understood...
2016: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/27616134/advanced-glycation-end-products-mechanics-of-aged-collagen-from-molecule-to-tissue
#4
Alfonso Gautieri, Fabian S Passini, Unai Silván, Manuel Guizar-Sicairos, Giulia Carimati, Piero Volpi, Matteo Moretti, Alberto Redaelli, Martin Berli, Jess G Snedeker
Concurrent with a progressive loss of regenerative capacity, connective tissue aging is characterized by a progressive accumulation of Advanced Glycation End-products (AGEs). Besides being part of the typical aging process, type II diabetics are particularly affected by AGE accumulation due to abnormally high levels of systemic glucose that increases the glycation rate of long-lived proteins such as collagen. Although AGEs are associated with a wide range of clinical disorders, the mechanisms by which AGEs contribute to connective tissue disease in aging and diabetes are still poorly understood...
September 8, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27561427/detection-of-circulating-auto-antibodies-against-ribosylated-ldl-in-diabetes-patients
#5
Firoz Akhter, M Salman Khan, Mohammad Faisal, Abdulrahman A Alatar, Saheem Ahmad
BACKGROUND: This study analyzes effect of glycation on ApoB-100 residues by D-ribose as D-ribosylated-glycated LDL might be responsible for the cause of diabetes mellitus because of its far higher antigenic ability. The binding characteristics of circulating auto-antibodies in type 1 and type 2 diabetes patients against native and modified LDL were assessed. METHODS: T1 Diabetes (n = 43), T2 diabetes patients (n = 100) were examined by direct binding ELISA as well as inhibition ELISA, were compared with healthy age-matched controls (n = 50)...
August 26, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27526342/characterizing-harmful-advanced-glycation-end-products-ages-and-ribosylated-aggregates-of-yellow-mustard-seed-phytocystatin-effects-of-different-monosaccharides
#6
Azaj Ahmed, Anas Shamsi, Bilqees Bano
Advanced glycation end products (AGEs) are at the core of variety of diseases ranging from diabetes to renal failure and hence gaining wide consideration. This study was aimed at characterizing the AGEs of phytocystatin isolated from mustard seeds (YMP) when incubated with different monosaccharides (glucose, ribose and mannose) using fluorescence, ultraviolet, circular dichroism (CD) spectroscopy and microscopy. Ribose was found to be the most potent glycating agent as evident by AGEs specific fluorescence and absorbance...
January 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27454862/autoantibodies-to-post-translationally-modified-type-i-and-ii-collagen-in-charcot-neuroarthropathy-in-subjects-with-type-2-diabetes-mellitus
#7
Paola Rizzo, Dario Pitocco, Francesco Zaccardi, Enrico Di Stasio, Rocky Strollo, Alessandro Rizzi, Giuseppe Scavone, Federica Costantini, Marco Galli, Giovanni Tinelli, Andrea Flex, Salvatore Caputo, Paolo Pozzilli, Raffaele Landolfi, Giovanni Ghirlanda, Ahuva Nissim
AIMS: Charcot neuroarthropathy (CN) is a disabling complication, culminating in bone destruction and involving joints and articular cartilage with high inflammatory environment. Its real pathogenesis is as yet unknown. In autoinflammatory diseases, such as rheumatoid arthritis, characterized by inflammation and joint involvement, autoantibodies against oxidative post-translationally modified (oxPTM) collagen type I (CI) and type II (CII) were detected. Therefore, the aim of our study was to assess the potential involvement of autoimmunity in charcot neuroarthropathy, investigating the presence of autoantibodies oxPTM-CI and oxPTM-CII, in participants with charcot neuroarthropathy...
July 25, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27367504/beneficial-effects-of-berberine-on-oxidized-ldl-induced-cytotoxicity-to-human-retinal-m%C3%A3-ller-cells
#8
Dongxu Fu, Jeremy Y Yu, Anna R Connell, Shihe Yang, Michelle B Hookham, Rebecca McLeese, Timothy J Lyons
PURPOSE: Limited mechanistic understanding of diabetic retinopathy (DR) has hindered therapeutic advances. Berberine, an isoquinolone alkaloid, has shown favorable effects on glucose and lipid metabolism in animal and human studies, but effects on DR are unknown. We previously demonstrated intraretinal extravasation and modification of LDL in human diabetes, and toxicity of modified LDL to human retinal Müller cells. We now explore pathogenic effects of modified LDL on Müller cells, and the efficacy of berberine in mitigating this cytotoxicity...
June 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27351669/glycation-of-liver-cystatin-implication-on-its-structure-and-function
#9
Mir Faisal Mustafa, Bilqees Bano
The increased level of reducing sugars and their derivatives in a diabetic condition has been the main cause of protein related complications. The changes in native state of proteins upon glycation induce loss in the function and structure of proteins. This further leads to cell damage and accumulation of immune system inducing AGE formation. Here in the present study cystatin was purified from liver (BLC) through affinity chromatography and was incubated with glucose, fructose and ribose. Changes were observed in the intensity of Trp absorption at 280 nm as well as AGE's specific fluorescence at 435 nm upon excitation at 370 nm to monitor the formation of BLC-sugar adducts...
September 2016: Journal of Fluorescence
https://www.readbyqxmd.com/read/27341846/diabetic-neuropathy-update-on-pathophysiological-mechanism-and-the-possible-involvement-of-glutamate-pathways
#10
Nadia Hussain, Thomas E Adrian
INTRODUCTION: Diabetic neuropathy is a common complication of diabetes. It adversely affects the lives of most diabetics. It is the leading cause of non-traumatic limb amputation. Diabetic autonomic neuropathy can target any system and increases morbidity and mortality. Treatment begins with adequate glycemic control but despite this, many patients go on to develop neuropathy which suggests there are additional and unidentified, as yet, pathological mechanisms in place. Although several theories exist, the exact mechanisms are not yet established...
June 24, 2016: Current Diabetes Reviews
https://www.readbyqxmd.com/read/27134467/in-vitro-screening-on-amyloid-beta-modulation-of-aqueous-extracts-from-plant-seeds
#11
Yoshinori Okada, Mizue Okada
INTRODUCTION: Glycation process might contribute to both extensive protein cross-linking and oxidative stress in Alzheimer's disease (AD). The amyloid-like aggregation of glycated bovine serum albumin induces apoptosis in the neuronal cell. Dietary supplementation of antioxidants, vitamins, and polyphenols are beneficial to AD, and consumption of fruits and vegetables reduce the risk of AD. We conducted a screening of 14 aqueous extracts from plant seeds (PSAE) for inhibitory activity on amyloid beta (Aβ)...
April 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27101975/glucitol-core-containing-gallotannins-inhibit-the-formation-of-advanced-glycation-end-products-mediated-by-their-antioxidant-potential
#12
Hang Ma, Weixi Liu, Leslie Frost, Louis J Kirschenbaum, Joel A Dain, Navindra P Seeram
Glucitol-core containing gallotannins (GCGs) are polyphenols containing galloyl groups attached to a 1,5-anhydro-d-glucitol core, which is uncommon among naturally occurring plant gallotannins. GCGs have only been isolated from maple (Acer) species, including the red maple (Acer rubrum), a medicinal plant which along with the sugar maple (Acer saccharum), are the major sources of the natural sweetener, maple syrup. GCGs are reported to show antioxidant, α-glucosidase inhibitory, and antidiabetic effects, but their antiglycating potential is unknown...
May 18, 2016: Food & Function
https://www.readbyqxmd.com/read/27080730/eucommia-ulmoides-extracts-prevent-the-formation-of-advanced-glycation-end-products
#13
Hikari Sugawa, Rei-Ichi Ohno, Jun-Ichi Shirakawa, Akari Nakajima, Amane Kanagawa, Tetsuya Hirata, Tsuyoshi Ikeda, Narumi Moroishi, Mime Nagai, Ryoji Nagai
Proteins non-enzymatically react with reducing sugars to form advanced glycation end-products (AGEs), resulting in the induction of protein denaturation. Because the levels of AGE increase with age and are elevated in age-related diseases, such as diabetes and atherosclerosis, the intake of compound(s) that inhibit the formation of AGEs by daily meal may represent a potential strategy for preventing age-related diseases. In this study, we measured the inhibitory effects of several Eucommia ulmoides extracts on the formation of AGEs, N(ε)-(carboxymethyl)lysine (CML) and N(ω)-(carboxymethyl)arginine (CMA)...
June 15, 2016: Food & Function
https://www.readbyqxmd.com/read/26907243/phenolics-from-garcinia-mangostana-inhibit-advanced-glycation-endproducts-formation-effect-on-amadori-products-cross-linked-structures-and-protein-thiols
#14
Hossam M Abdallah, Hany El-Bassossy, Gamal A Mohamed, Ali M El-Halawany, Khalid Z Alshali, Zainy M Banjar
Accumulation of Advanced Glycation Endproducts (AGEs) in body tissues plays a major role in the development of diabetic complications. Here, the inhibitory effect of bioactive metabolites isolated from fruit hulls of Garcinia mangostana on AGE formation was investigated through bio-guided approach using aminoguanidine (AG) as a positive control. Including G. mangostana total methanol extract (GMT) in the reaction mixture of bovine serum albumin (BSA) and glucose or ribose inhibited the fluorescent and non-fluorescent AGEs formation in a dose dependent manner...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26874030/antigenic-role-of-the-adaptive-immune-response-to-d-ribose-glycated-ldl-in-diabetes-atherosclerosis-and-diabetes-atherosclerotic-patients
#15
Firoz Akhter, M Salman Khan, Abdulrahman A Alatar, Mohammad Faisal, Saheem Ahmad
AIMS: Glycation of proteins leads to the formation of advanced glycation end products (AGEs, which have significant role in the pathophysiology of diabetes complications. d-ribose appears to be the most reactive among the naturally occurring sugars and contribute significantly to the generation of AGEs. Glycation also results in the generation of free radicals causing structural modification which leads to the generation of neoantigenic epitopes. The aim of the present study was to investigate whether LDL modification results in auto-antibodies formation against its glycated conformer in diabetes and atherosclerosis patients...
April 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/26816666/hyperglycemic-stress-and-carbon-stress-in-diabetic-glucotoxicity
#16
REVIEW
Xiaoting Luo, Jinzi Wu, Siqun Jing, Liang-Jun Yan
Diabetes and its complications are caused by chronic glucotoxicity driven by persistent hyperglycemia. In this article, we review the mechanisms of diabetic glucotoxicity by focusing mainly on hyperglycemic stress and carbon stress. Mechanisms of hyperglycemic stress include reductive stress or pseudohypoxic stress caused by redox imbalance between NADH and NAD(+) driven by activation of both the polyol pathway and poly ADP ribose polymerase; the hexosamine pathway; the advanced glycation end products pathway; the protein kinase C activation pathway; and the enediol formation pathway...
January 2016: Aging and Disease
https://www.readbyqxmd.com/read/26814613/microfluidic-based-non-enzymatic-glycation-enhances-cross-linking-of-human-scleral-tissue-compared-to-conventional-soaking
#17
Samjin Choi, Sang Woong Moon, Kyung-Hyun Jin, Jae-Ho Shin
We evaluated nano-structural and chemical changes in human scleral collagen caused by non-enzymatic glycation using AFM, Raman spectroscopy, and microfluidics. Twenty 8 × 2 mm(2) scleral strips (n = 5, each) were divided into four groups of pure sclera tissues (control group) and sclera tissues with incubation (1 hr in BSS and ribose) and preservation (23 hr in 90% ethanol) for 7 days (BSS + DR7 group) and 30 days (BSS + DR30 group) at room temperature, and 7 days in a microfluidic chip (BSS + DR + µF7 group)...
January 27, 2016: Scanning
https://www.readbyqxmd.com/read/26758618/two-new-prenylflavonoids-from-epimedii-herba-and-their-inhibitory-effects-on-advanced-glycation-end-products
#18
Keisuke Nakashima, Hiroyuki Miyashita, Hitoshi Yoshimitsu, Yukio Fujiwara, Ryoji Nagai, Tsuyoshi Ikeda
Because inhibitors of advanced glycation end-products (AGEs), for example pyridoxamine, significantly inhibit the development of retinopathy and neuropathy in rats with streptozotocin-induced diabetes, treatment with AGE inhibitors is believed to be a potential strategy for the prevention of lifestyle-related diseases such as diabetic complications. In the present study, the MeOH extract of Epimedii Herba (EH; aerial parts of Epimedium spp.) was found to inhibit the formation of N (ε) -(carboxymethyl)lysine (CML) and N (ω) -(carboxymethyl)arginine (CMA) during incubation of collagen-derived gelatin with ribose...
April 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/26461390/polyphenols-protect-against-protein-glycoxidation
#19
Izabela Sadowska-Bartosz, Sabina Galiniak, Grzegorz Bartosz
Glycoxidation belongs to posttranslational protein modifications which underlie pathological sequelae of diabetes and other diseases, and contribute to aging. Search for efficient inhibitors of glycoxidation is therefore of considerable importance. We studied the effect of various polyphenols on the glycoxidation of bovine serum albumin (90 uM) incubated in vitro with glucose, fructose or ribose (100mM) for 6 days in 0.1M phosphate buffer, pH 7.4. Polyphenols have multiple biological actions including antioxidant activity and chelation of transition metal ions...
October 2014: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/26453295/lycopene-powers-the-inhibition-of-glycation-induced-diabetic-nephropathy-a-novel-approach-to-halt-the-age-rage-axis-menace
#20
Shams Tabrez, Khalid Zaki Al-Shali, Saheem Ahmad
There are accumulating evidences suggesting that interaction between advanced glycation end products (AGEs) and their receptors (RAGEs) induces oxidative stress and subsequently encourages inflammatory reactions, thereby resulting in progressive alteration in renal architecture and function. Interventions that reduce the tissue burden of AGEs have yielded significant positive results in inhibiting the progression of diabetic complications such as diabetic nephropathy. Lycopene, a carotenoid, plays an important role in protection against oxidative stress and hence might prove an efficient antiglycating agent...
September 2015: BioFactors
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