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myo-inositol

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https://www.readbyqxmd.com/read/28644842/investigation-of-discriminant-metabolites-in-tamoxifen-resistant-and-choline-kinase-alpha-downregulated-breast-cancer-cells-using-1h-nuclear-magnetic-resonance-spectroscopy
#1
Hoe Suk Kim, Lianji Tian, Hyeonjin Kim, Woo Kyung Moon
Metabolites linked to changes in choline kinase-α (CK-α) expression and drug resistance, which contribute to survival and autophagy mechanisms, are attractive targets for breast cancer therapies. We previously reported that autophagy played a causative role in driving tamoxifen (TAM) resistance of breast cancer cells (BCCs) and was also promoted by CK-α knockdown, resulting in the survival of TAM-resistant BCCs. There is no comparative study yet about the metabolites resulting from BCCs with TAM-resistance and CK-α knockdown...
2017: PloS One
https://www.readbyqxmd.com/read/28642705/polycystic-ovary-syndrome-insights-into-the-therapeutic-approach-with-inositols
#2
REVIEW
Maria A Sortino, Salvatore Salomone, Michele O Carruba, Filippo Drago
Polycystic ovary syndrome (PCOS) is characterized by hormonal abnormalities that cause menstrual irregularity and reduce ovulation rate and fertility, associated to insulin resistance. Myo-inositol (cis-1,2,3,5-trans-4,6-cyclohexanehexol, MI) and D-chiro-inositol (cis-1,2,4-trans-3,5,6-cyclohexanehexol, DCI) represent promising treatments for PCOS, having shown some therapeutic benefits without substantial side effects. Because the use of inositols for treating PCOS is widespread, a deep understanding of this treatment option is needed, both in terms of potential mechanisms and efficacy...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28640119/relationships-between-dorsolateral-prefrontal-cortex-metabolic-change-and-cognitive-impairment-in-first-episode-neuroleptic-naive-schizophrenia-patients
#3
Man-Li Huang, Thong-Teck Khoh, Shao-Jia Lu, Fen Pan, Jin-Kai Chen, Jian-Bo Hu, Shao-Hua Hu, Wei-Juan Xu, Wei-Hua Zhou, Ning Wei, Hong-Li Qi, De-Sheng Shang, Yi Xu
The present study aimed to explore the possible associations between the dorsolateral prefrontal cortex (DLPFC) metabolites and the cognitive function in first-episode schizophrenia (FES).This study included 58 patients with FES (29 males and 29 females; mean age, 22.66 ± 7.64 years) recruited from the First Affiliated Hospital, College of Medicine, Zhejiang University, and 43 locally recruited healthy controls (16 males and 27 females; mean age, 23.07 ± 7.49 years). The single-voxel proton magnetic resonance spectroscopy was used to measure the levels of N-acetylaspartate (NAA); complex of glutamate, glutamine, and γ-aminobutyric acid (Glx); choline-containing compounds; and myo-inositol in the DLPFC...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28629791/inositol-phosphate-signaling-as-mediator-for-growth-and-sexual-reproduction-in-podospora-anserina
#4
Ning Xie, Gwenaël Ruprich-Robert, Florence Chapeland-Leclerc, Evelyne Coppin, Hervé Lalucque, Sylvain Brun, Robert Debuchy, Philippe Silar
The molecular pathways involved in the development of multicellular fruiting bodies in fungi are still not well known. Especially, the interplay between the mycelium, the female tissues and the zygotic tissues of the fruiting bodies is poorly documented. Here, we describe PM154, a new strain of the model ascomycetes Podospora anserina able to mate with itself and that enabled the easy recovery of new mutants affected in fruiting body development. By complete genome sequencing of spod1, one of the new mutants, we identified an inositol phosphate polykinase gene as essential, especially for fruiting body development...
June 16, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28629498/rodentibacter-gen-nov-including-rodentibacter-pneumotropicus-comb-nov-rodentibacter-heylii-sp-nov-rodentibacter-myodis-sp-nov-rodentibacter-ratti-sp-nov-rodentibacter-heidelbergensis-sp-nov-rodentibacter-trehalosifermentans-sp-nov-rodentibacter-rarus-sp-nov
#5
Sadhana Adhikary, Werner Nicklas, Magne Bisgaard, Ron Boot, Peter Kuhnert, Torsten Waberschek, Bent Aalbæk, Bozena Korczak, Henrik Christensen
Rodentibacter gen. nov. is proposed based on isolation and phenotypic characterization of strains, predominantly from rodents. The strains showed 86 % or higher rpoB gene sequence similarity and indicated a genus-level relationship within Pasteurellaceae. The strains compared at 16S rRNA gene sequence level showed 93.8 % or higher similarity, and their genus-level relationship within Pasteurellaceae was confirmed by phenotypic analysis. The type species Rodentibacter pneumotropicus comb. nov. is reclassified from [Pasteurella] pneumotropica with type strain NCTC 8141T (=CCUG 12398T)...
June 20, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28610850/dietary-myo-inositol-deficiency-decreased-the-growth-performances-and-impaired-intestinal-physical-barrier-function-partly-relating-to-nrf2-jnk-e2f4-and-mlck-signaling-in-young-grass-carp-ctenopharyngodon-idella
#6
Shuang-An Li, Wei-Dan Jiang, Lin Feng, Yang Liu, Pei Wu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou
In this study, we investigated the effects of dietary myo-inositol on the growth and intestinal physical barrier functions of young grass carp (Ctenopharyngodon idella). A total of 540 young grass carp (221.83 ± 0.84 g) were fed six diets containing graded levels of myo-inositol (27.0, 137.9, 286.8, 438.6, 587.7 and 737.3 mg/kg) for 10 weeks. After the growth trial, fish were challenged with Aeromonas hydrophila for 14 days. The results indicated that compared with optimal myo-inositol levels, myo-inositol deficiency (27...
June 10, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28600316/an-in-vitro-enzyme-system-for-the-production-of-myo-inositol-from-starch
#7
Tomoko Fujisawa, Shohei Fujinaga, Haruyuki Atomi
We developed an in vitro enzyme system to produce myo-inositol from starch. Four enzymes were used, maltodextrin phosphorylase (MalP), phosphoglucomutase (PGM), myo-inositol-3-phosphate synthase (MIPS) and myo-inositol monophosphatase (IMPase). The enzymes were thermostable; MalP and PGM from the hyperthermophilic archaeon Thermococcus kodakarensis, MIPS from the hyperthermophilic archaeon Archaeoglobus fulgidus and IMPase from the hyperthermophilic bacterium Thermotoga maritima Enzymes were individually produced in Escherichia coli, and partially purified by subjecting cell extracts to heat treatment and removing denatured proteins...
June 9, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28598285/effect-of-non-surgical-periodontal-therapy-along-with-myo-inositol-on-high-sensitivity-c-reactive-protein-and-insulin-resistance-in-polycystic-ovary-syndrome-women-having-chronic-periodontitis-a-randomized-controlled-trial
#8
Dr Deepti, Dr Shikha Tewari, Dr Satish Chander Narula, Dr Savita Rani Singhal, Dr Rajinder Kumar Sharma
BACKGROUND: The purpose of this study was to evaluate the effect of non-surgical periodontal therapy along with medical treatment on the level of serological marker of inflammation {high sensitivity-C Reactive Protein (hsCRP)} and Insulin resistance{Homeostatic Model Assessment(HOMA)} in Polycystic ovarian syndrome (PCOS) women having periodontitis. METHODS: Women having PCOS with chronic periodontitis (n=60) were randomly divided into two groups. Test Group: treated with scaling and root planing along with Myo-inositol and Control Group: treated with Myo-inositol along with oral hygiene instructions...
June 9, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28592827/a-comprehensive-characterisation-of-the-metabolic-profile-of-varicose-veins-implications-in-elaborating-plausible-cellular-pathways-for-disease-pathogenesis
#9
Muzaffar A Anwar, Kyrillos N Adesina-Georgiadis, K Spagou, P A Vorkas, J V Li, Joseph Shalhoub, Elaine Holmes, Alun H Davies
Metabolic phenotypes reflect both the genetic and environmental factors which contribute to the development of varicose veins (VV). This study utilises analytical techniques to provide a comprehensive metabolic picture of VV disease, with the aim of identifying putative cellular pathways of disease pathogenesis. VV (n = 80) and non-VV (n = 35) aqueous and lipid metabolite extracts were analysed using 600 MHz (1)H Nuclear Magnetic Resonance spectroscopy and Ultra-Performance Liquid Chromatography Mass Spectrometry...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28592011/-gas-chromatography-mass-spectrometry-based-urinary-metabolomics-in-very-low-birth-weight-premature-infants
#10
S T Li, X L Huang, S G Wu, Y M Ma, C C Shi, X Xiao, H Hao
Objective: To investigate the urinary metabolic spectrum and pathways in very low birth weight (VLBW) premature infants. Method: A prospective case-control study was conducted to collect and compare the data of VLBW premature infants and full term infants from the Sixth Affiliated Hospital of Sun Yet-Sen University in 2014. Within 24 hours after birth, urine specimens in each group were collected. Metabolites of urine samples including amino acid, fatty acid and organic acid were detected using the urease pre-processing and gas chromatography mass spectrometry (GC-MS) technology...
June 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28578198/synthesis-of-%C3%A2-myo-inositol-4-methylenephosphonate-via-rh-catalyzed-hydrogenation-of-vinylphosphonate
#11
Tatsuo Okauchi, Shuya Nakamura, Kouta Tsubaki, Momoko Asakawa, Mitsuru Kitamura
Phosphatidylinositol phosphate (PIP) synthetase is a promising target for the development of new anti-mycobacterium compounds. We previously reported that myo-inositol 1-methylenephosphonate showed inhibitory activity against PIP synthetase. Herein, we report the synthesis of unprotected myo-inositol 4-methylenephosphonate, a constitutional isomer of myo-inositol 1-methylenephosphonate and found that the stereoselective hydrogenation of vinylphosphonate proceeded via Rh catalysis.
May 29, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28578037/bioaccessibility-of-calcium-iron-and-magnesium-in-residues-of-citrus-and-characterization-of-macronutrients
#12
Joyce Grazielle Siqueira Silva, Ana Paula Rebellato, Ralf Greiner, Juliana Azevedo Lima Pallone
The aim of this study was to estimate bioaccessibility of Ca, Fe and Mg in residues of orange, lime, and their mixture, in order to evaluate the effects of cooking in water on mineral bioaccessibility and also to determine the composition of macronutrients and myo-inositol phosphate content. The citrus samples contained on average 9.53g/100 g moisture, 6.09g/100 g protein, 3.23g/100g ash, 3.15g/100g lipids, 34.26g/100g insoluble fiber, 27.88g/100g soluble fiber and 25.64g/100g carbohydrates. The percentage of soluble and dialyzable minerals ranged from 19...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28559071/magnetic-resonance-spectroscopy-findings-in-patients-with-dural-arteriovenous-fistulas-three-case-reports
#13
Hiroaki Nagashima, Atsushi Fujita, Jun Tanaka, Masaaki Kohta, Takashi Sasayama, Kazuhiro Tanaka, Kohkichi Hosoda, Eiji Kohmura
BACKGROUND: Magnetic resonance spectroscopy (MRS) is a potentially useful modality for evaluating brain metabolites in patients with dural arteriovenous fistula (dAVF). Here, we propose a different pattern of MRS-based cerebral metabolism findings in patients with dAVF. CASE DESCRIPTION: We performed MRS in three patients with transverse sigmoid sinus dAVF associated with cortical venous reflux. In case 1, which was associated with vasogenic edema on T2-weighted imaging, decreasing preoperative N-acetylaspartate/creatine, myo-inositol/creatine and increasing lactate/creatine ratios improved after treatment...
May 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28554270/dephosphorylation-of-myo-inositol-phosphates-in-the-in-vitro-intestinal-caco-2-cell-model
#14
Karlis Briviba, Margit Schollenberger, Markus Rodehutscord, Ralf Greiner
Plant and microbial phytases present in raw materials can cause a dephosphorylation of phytate (myo-inositol hexakisphosphate) (InsP6)) during food processing resulting in a broad range of different myo-inositol phosphates such as pentakisphosphate (InsP5) and tetrakisphosphate (InsP4) in foods. Here, we investigated whether the human intestinal epithelium is able to dephosphorylate myo-inositol phosphates (InsP6, InsP5-, InsP4-, InsP3-isomers) using an in vitro model with differentiated human Caco-2 cells cultured on semipermeable inserts...
May 30, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28552568/miniaturized-and-automated-adaptive-laboratory-evolution-evolving-corynebacterium-glutamicum-towards-an-improved-d-xylose-utilization
#15
Andreas Radek, Niklas Tenhaef, Moritz Fabian Müller, Christian Brüsseler, Wolfgang Wiechert, Jan Marienhagen, Tino Polen, Stephan Noack
Adaptive Laboratory Evolution (ALE) is increasingly being used as a technique for untargeted strain optimization. This work aimed at developing an automated and miniaturized ALE approach based on repetitive batch cultivations in microtiter plates. The new method is applied to the recently published strain Corynebacterium glutamicum pEKEx3-xylXABCDCc, which is capable of utilizing d-xylose via the Weimberg (WMB) pathway. As a result, the significantly improved strain WMB2evo was obtained, showing a specific growth rate of 0...
May 12, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28551271/comparison-of-fruit-quality-and-gc-ms-based-metabolite-profiling-of-kiwifruit-jecy-green-natural-and-exogenous-ethylene-induced-ripening
#16
Sooyeon Lim, Jeong Gu Lee, Eun Jin Lee
We applied exogenous ethylene to 'Jecy green' kiwifruit to elucidate the differences in fruit quality and metabolite profiling between naturally ripe (NR) and ethylene-induced ripe (ER) kiwifruit. Kiwifruit were exposed to ethylene (200μL/L) for 12h at 20°C and maintained for 9days at 20°C. Two metabolites of ascorbic acid and arabinose significantly decreased during kiwifruit ripening regardless of the ripening method. The concentrations of sucrose, myo-inositol, citric acid, and malic acid in NR fruit were substantially higher than those in ER fruit, while the concentrations of fructose, glucose, and quinic acid in ER fruit were higher than those in NR fruit...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28548710/measurement-of-glycine-in-healthy-and-tumorous-brain-by-triple-refocusing-mrs-at-3%C3%A2-t-in-vivo
#17
Vivek Tiwari, Zhongxu An, Sandeep K Ganji, Jeannie Baxter, Toral R Patel, Edward Pan, Bruce E Mickey, Elizabeth A Maher, Marco C Pinho, Changho Choi
Glycine (Gly) has been implicated in several neurological disorders, including malignant brain tumors. The precise measurement of Gly is challenging largely as a result of the spectral overlap with myo-inositol (mI). We report a new triple-refocusing sequence for the reliable co-detection of Gly and mI at 3 T and for the evaluation of Gly in healthy and tumorous brain. The sequence parameters were optimized with density-matrix simulations and phantom validation. With a total TE of 134 ms, the sequence gave complete suppression of the mI signal between 3...
May 26, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28544572/inositol-treatment-of-anovulation-in-women-with-polycystic-ovary-syndrome-a-meta-analysis-of-randomised-trials
#18
Jyotsna Pundir, Dimitrios Psaroudakis, Prakash Savnur, Priya Bhide, Luca Sabatini, Helena Teede, Arri Coomarasamy, Shakila Thangaratinam
BACKGROUND: Polycystic ovary syndrome is a common cause of anovulation and infertility, and a risk factor for development of metabolic syndrome and endometrial cancer. OBJECTIVES: Systematic review and meta-analysis of randomised controlled trials that evaluated the effects of inositol as an ovulation-induction agent. SEARCH STRATEGY: We searched MEDLINE, EMBASE, Cochrane and ISI conference proceedings, Register and Meta-register for RCTs and WHO trials' search portal...
May 24, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28542579/transcriptomic-dissection-reveals-wide-spread-differential-expression-in-chickpea-during-early-time-points-of-fusarium-oxysporum-f-sp-ciceri-race-1-attack
#19
Sumanti Gupta, Anirban Bhar, Moniya Chatterjee, Amartya Ghosh, Sampa Das
Plants' reaction to underground microorganisms is complex as sessile nature of plants compels them to prioritize their responses to diverse microorganisms both pathogenic and symbiotic. Roots of important crops are directly exposed to diverse microorganisms, but investigations involving root pathogens are significantly less. Thus, more studies involving root pathogens and their target crops are necessitated to enrich the understanding of underground interactions. Present study reported the molecular complexities in chickpea during Fusarium oxysporum f...
2017: PloS One
https://www.readbyqxmd.com/read/28523763/proton-mr-spectroscopy-of-lesion-evolution-in-multiple-sclerosis-steady-state-metabolism-and-its-relationship-to-conventional-imaging
#20
Ivan I Kirov, Shu Liu, Assaf Tal, William E Wu, Matthew S Davitz, James S Babb, Henry Rusinek, Joseph Herbert, Oded Gonen
Although MRI assessment of white matter lesions is essential for the clinical management of multiple sclerosis, the processes leading to the formation of lesions and underlying their subsequent MRI appearance are incompletely understood. We used proton MR spectroscopy to study the evolution of N-acetyl-aspartate (NAA), creatine (Cr), choline (Cho), and myo-inositol (mI) in pre-lesional tissue, persistent and transient new lesions, as well as in chronic lesions, and related the results to quantitative MRI measures of T1-hypointensity and T2-volume...
May 19, 2017: Human Brain Mapping
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