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myo-inositol

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https://www.readbyqxmd.com/read/29052415/activity-of-escherichia-coli-aspergillus-niger-and-rye-phytase-towards-partially-phosphorylated-myo-inositol-phosphates
#1
Ralf Greiner
Kinetic parameters for the dephosphorylation of sodium phytate and a series of partially phosphorylated myo-inositol phosphates were determined at pH 3.0 and pH 5.0 for three phytase preparations (Aspergillus niger, Escherichia coli, rye). The enzymes showed lower affinity and turnover numbers at pH 3 compared to pH 5 towards all myo-inositol phosphates included in the study. The number and distribution of phosphate groups on the myo-inositol ring affected the kinetic parameters. Representatives of the individual phytate dephosphorylation pathways were identified as the best substrates of the phytases...
October 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29048873/insights-into-mycobacteria-interactions-with-the-host-innate-immune-system-from-a-novel-array-of-synthetic-mycobacterial-glycans
#2
Ruixiang Blake Zheng, Sabine A F Jégouzo, Maju Joe, Yu Bai, Huu-Anh Tran, Ke Shen, Jörn Saupe, Li Xia, Md Faiaz Ahmed, Yu-Hsuan Liu, Pratap Subhashrao Patil, Ashish Tripathi, Shang-Cheng Hung, Maureen E Taylor, Todd L Lowary, Kurt Drickamer
An array of homogenous glycans representing all the major carbohydrate structures present in the cell wall of the human pathogen Mycobacterium tuberculosis and other mycobacteria has been probed with a panel of glycan-binding receptors expressed on cells of the mammalian innate immune system. The results provide an overview of interactions between mycobacterial glycans and receptors that mediate uptake and survival in macrophages, dendritic cells and sinusoidal endothelial cells. A subset of the wide variety of glycan structures present on mycobacterial surfaces interact with cells of the innate immune system through the receptors tested...
October 19, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29044690/apparent-diffusion-coefficients-of-the-five-major-metabolites-measured-in-the-human-brain-in-vivo-at-3t
#3
Dinesh K Deelchand, Edward J Auerbach, Małgorzata Marjańska
PURPOSE: To measure the apparent diffusion coefficients (ADC) of five main metabolites in the human brain at 3T with PRESS and STEAM, avoiding measurement biases because of cross-terms. Cross-terms arise from interactions between slice-selection and spoiler gradients in the localized spectroscopy sequence and the diffusion gradients. METHODS: Diffusion-weighted spectra were acquired from the prefrontal cortex in five healthy subjects using STEAM (echo time [TE]/mixing time [TM]/pulse repetition time [TR] = 21...
October 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29042448/myo-inositol-effects-in-women-with-pcos-a-meta-analysis-of-randomized-controlled-trials
#4
Vittorio Unfer, Fabio Facchinetti, Beatrice Orrù, Barbara Giordani, John Nestler
Myo-inositol (MI) supplementation in women with polycystic ovary syndrome (PCOS) has been evaluated over the last years. Many hormonal and reproductive impairments associated with this disorder seem relieved by the supplement. The objective of the meta-analysis was to assess the effects of MI alone or combined with d-chiro-inositol (DCI) on the endocrine and metabolic abnormalities of women with PCOS. Literature was retrieved from selected databases, MEDLINE, EMBASE, PubMed and Research Gate (up to November 2016)...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29037103/ameliorative-effect-of-myo-inositol-on-red-blood-cell-alterations-in-polycystic-ovary-syndrome-in-vitro-study
#5
Alessandra Andrisani, Gabriella Donà, Chiara Sabbadin, Elena Tibaldi, Francesco Dessole, Valentina Bosello Travain, Loris Marin, Anna Maria Brunati, Guido Ambrosini, Decio Armanini, Eugenio Ragazzi, Luciana Bordin
Polycystic ovary syndrome (PCOS)is a gynecological endocrine disorder which is associated with systemic inflammatory status inducing red blood cells (RBC) membrane alterations related to insulin resistance and testosterone levels which could be greatly improved by myo-inositol (MYO) uptake. In this study we aim to evaluate the effect of MYO in reducing oxidative-related alterations through in vitro study on PCOS RBC. Blood samples from two groups of volunteers, control group (CG, n = 12) and PCOS patient group (PG, n = 12), were analyzed for band 3 tyrosine phosphorylation (Tyr-P), high molecular weight aggregate (HMWA), IgG in RBC membranes, and glutathione (GSH) in cytosol, following O/N incubation in the presence or absence of MYO...
October 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29030186/counteraction-of-the-deleterious-effects-of-urea-on-structure-and-stability-of-mammalian-kidney-proteins-by-osmolytes
#6
Mohammad Aasif Dar, Wahiduzzaman, Asimul Islam, Md Imtaiyaz Hassan, Faizan Ahmad
Owing to the urine concentrating mechanism of kidney cells, urea concentration is very high (3.0-5.0M) in mammalian kidneys which may denature many kidney proteins. Methylamines are known to counteract the deleterious effects of urea on structure, stability and function of proteins at 2:1 molar ratio of urea to methylamines. It is known that mammalian kidney cells also contain stabilizing osmolytes, non-methylamines (myo-inositol and sorbitol). A question arises: Do these non-methylmine osmolytes have ability to counteract the deleterious effects of urea on kidney proteins? To answer this question, we took two kidney proteins, namely, sheep serum albumin and Human carbonic anhydrase II...
October 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29019688/yb-otf-3-catalyzed-desymmetrization-of-myo-inositol-1-3-5-orthoformate-and-its-application-in-the-synthesis-of-chiral-inositol-phosphates
#7
Laxmansingh T Padiyar, Medel Manuel L Zulueta, Narayana Murthy Sabbavarapu, Shang-Cheng Hung
A variety of inositol phosphates including myo-inositol-1,4,5-trisphosphate, which is a secondary messenger in transmembrane signaling, were selectively synthesized via Yb(OTf)3-catalyzed desymmetrization of myo-inositol-1,3,5-orthoformate using a proline-based chiral anhydride as an acylation precursor. The investigated catalytic system could regioselectively differentiate the enantiotopic hydroxy groups of myo-inositol-1,3,5-orthoformate in the presence of a chiral auxiliary. This key step to generate a suitably protected chiral myo-inositol derivatives is described here as a unified approach to access inositol phosphates...
October 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29017444/quantitative-trait-loci-associated-with-different-polar-metabolites-in-perennial-ryegrass-providing-scope-for-breeding-towards-increasing-certain-polar-metabolites
#8
Alexandre Foito, Christine Anne Hackett, Derek Stewart, Janaki Velmurugan, Dan Milbourne, Stephen L Byrne, Susanne Barth
BACKGROUND: Recent advances in the mapping of biochemical traits have been reported in Lolium perenne. Although the mapped traits, including individual sugars and fatty acids, contribute greatly towards ruminant productivity, organic acids and amino acids have been largely understudied despite their influence on the ruminal microbiome. RESULTS: In this study, we used a targeted gas-chromatography mass spectrometry (GC-MS) approach to profile the levels of 25 polar metabolites from different classes (sugars, amino acids, phenolic acids, organic acids and other nitrogen-containing compounds) present in a L...
October 10, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28988409/the-nutritional-and-health-benefits-of-kiwiberry-actinidia-arguta-a-review
#9
Piotr Latocha
The kiwiberry (Actinidia arguta) is a new product on the market that is enjoying growing consumer acceptance around the world. This widespread interest has created increased demand for identification of the kiwiberry's nutritional health benefits. Containing over 20 essential nutrients and a range of vitamins, the kiwiberry comes near the top of fruits classed as superfoods. It is one of the richest sources of vitamin C with up to 430 mg/100 g fresh weight (FW) and is considered the richest dietary source of myo-inositol (up to 982 mg/100 g FW)...
October 7, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28981890/overexpression-of-atgols3-and-csrfs-in-poplar-enhances-ros-tolerance-and-represses-defense-response-to-leaf-rust-disease
#10
Jonathan La Mantia, Faride Unda, Carl J Douglas, Shawn D Mansfield, Richard Hamelin
Plants respond to pathogens through an orchestration of signaling events that coordinate modifications to transcriptional profiles and physiological processes. Resistance to necrotrophic pathogens often requires jasmonic acid, which antagonizes the salicylic acid dependent biotrophic defense response. Recently, myo-inositol has been shown to negatively impact salicylic acid (SA) levels and signaling, while galactinol enhances jasmonic acid (JA)-dependent induced systemic resistance to necrotrophic pathogens...
August 30, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28980941/cerebral-mglur5-availability-contributes-to-elevated-sleep-need-and-behavioral-adjustment-after-sleep-deprivation
#11
Sebastian C Holst, Alexandra Sousek, Katharina Hefti, Sohrab Saberi-Moghadam, Alfred Buck, Simon M Ametamey, Milan Scheidegger, Paul Franken, Anke Henning, Erich Seifritz, Mehdi Tafti, Hans-Peter Landolt
Increased sleep time and intensity quantified as low-frequency brain electrical activity after sleep loss demonstrate that sleep need is homeostatically regulated, yet the underlying molecular mechanisms remain elusive. We here demonstrate that metabotropic glutamate receptors of subtype 5 (mGluR5) contribute to the molecular machinery governing sleep-wake homeostasis. Using positron emission tomography, magnetic resonance spectroscopy, and electroencephalography in humans, we find that increased mGluR5 availability after sleep loss tightly correlates with behavioral and electroencephalographic biomarkers of elevated sleep need...
October 5, 2017: ELife
https://www.readbyqxmd.com/read/28980870/comparison-of-myo-inositol-and-metformin-on-mental-health-parameters-and-biomarkers-of-oxidative-stress-in-women-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#12
Hamidreza Jamilian, Mehri Jamilian, Fatemeh Foroozanfard, Faraneh Afshar Ebrahimi, Fereshteh Bahmani, Zatollah Asemi
INTRODUCTION: Data on comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in subjects with polycystic ovary syndrome (PCOS) are scarce. This purpose of this study was to compare of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in subjects with PCOS. METHODS: This randomized controlled trial was conducted among 60 subjects diagnosed with PCOS according to the Rotterdam criteria...
October 5, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28968410/distinguishing-neuronal-from-astrocytic-subcellular-microstructures-using-in-vivo-double-diffusion-encoded-1h-mrs-at-21-1-t
#13
Noam Shemesh, Jens T Rosenberg, Jean-Nicolas Dumez, Samuel C Grant, Lucio Frydman
Measuring cellular microstructures non-invasively and achieving specificity towards a cell-type population within an interrogated in vivo tissue, remains an outstanding challenge in brain research. Magnetic Resonance Spectroscopy (MRS) provides an opportunity to achieve cellular specificity via the spectral resolution of metabolites such as N-Acetylaspartate (NAA) and myo-Inositol (mI), which are considered neuronal and astrocytic markers, respectively. Yet the information typically obtained with MRS describes metabolic concentrations, diffusion coefficients or relaxation rates rather than microstructures...
2017: PloS One
https://www.readbyqxmd.com/read/28968236/decreased-n-acetyl-aspartate-myo-inositol-ratio-in-the-posterior-cingulate-cortex-shown-by-magnetic-resonance-spectroscopy-may-be-one-of-the-risk-markers-of-preclinical-alzheimer-s-disease-a-7-year-follow-up-study
#14
Masaaki Waragai, Masaru Moriya, Takeshi Nojo
Although molecular positron emission tomography imaging of amyloid and tau proteins can facilitate the detection of preclinical Alzheimer's disease (AD) pathology, it is not useful in clinical practice. More practical surrogate markers for preclinical AD would provide valuable tools. Thus, we sought to validate the utility of conventional magnetic resonance spectroscopy (MRS) as a screening method for preclinical AD. A total of 289 older participants who were cognitively normal at baseline were clinically followed up for analysis of MRS metabolites, including N-acetyl aspartate (NAA) and myo-inositol (MI) in the posterior cingulate cortex (PCC) for 7 years...
September 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28959094/marine-sponge-derived-natural-products-as-inhibitors-of-mycothiol-s-conjugate-amidase
#15
Akansha Saxena, Sanjay Mishra
Marine sponges have potential sources for secondary metabolites and are considered as a drug treasure house. In this work, 3D model of Mycothiol-S-conjugate amidase (Mca) was determined by comparative homology modeling program MODELLER based on the crystal structure of 1-D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis as a template. The computed model's energy was minimized and validated to obtain a stable model structure. Stable model was used for docking of nineteen bioactive compounds isolated from marine sponges against Mca using AutoDock 4...
2017: Bioinformation
https://www.readbyqxmd.com/read/28957808/regulation-of-intracellular-calcium-by-carbon-monoxide-in-human-bronchial-epithelial-cells
#16
Rui-Gang Zhang, Chung-Yin Yip, Wing-Hung Ko
BACKGROUND/AIMS: Carbon monoxide (CO) is an important autocrine/paracrine messenger involved in a variety of physiological and pathological processes. This study aimed to investigate the regulatory role of CO released by CO-releasing molecule-2 (CORM-2) in a P2Y receptor-mediated calcium-signaling pathway in the human bronchial epithelial cell line, 16HBE14o-. METHODS: Intracellular calcium ([Ca2+]i) was measured by fura-2 microspectrofluorimetry. D-myo-inositol-1-phosphate (IP1) levels and cGMP-dependent protein kinase activity (PKG) were also quantified...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28956379/-metabolic-engineering-of-saccharomyces-cerevisiae-for-production-of-glucaric-acid
#17
Xu Gong, Ye Liu, Cui Wang, Jianghua Li, Zhen Kang
Glucaric acid, a high value-added organic acid, is widely used in food, pharmaceutical and chemical industries. For microbial production of glucaric acid in Saccharomyces cerevisiae, we constructed a synthetic glucaric acid biosynthetic pathway by coexpressing the genes encoding myo-inositol oxygenase from mice and uronate dehydrogenase from Pseudomonas putida. Moreover, myo-inositol-1-phosphate synthase was identified as a rate-limiting enzyme in glucaric acid pathway and was upregulated, resulting in the production of glucaric acid of (107...
February 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28950028/an-evolutionary-analysis-identifies-a-conserved-pentapeptide-stretch-containing-the-two-essential-lysine-residues-for-rice-l-myo-inositol-1-phosphate-synthase-catalytic-activity
#18
Papri Basak, Susmita Maitra-Majee, Jayanta Kumar Das, Abhishek Mukherjee, Shubhra Ghosh Dastidar, Pabitra Pal Choudhury, Arun Lahiri Majumder
A molecular evolutionary analysis of a well conserved protein helps to determine the essential amino acids in the core catalytic region. Based on the chemical properties of amino acid residues, phylogenetic analysis of a total of 172 homologous sequences of a highly conserved enzyme, L-myo-inositol 1-phosphate synthase or MIPS from evolutionarily diverse organisms was performed. This study revealed the presence of six phylogenetically conserved blocks, out of which four embrace the catalytic core of the functional protein...
2017: PloS One
https://www.readbyqxmd.com/read/28947252/tonebp-nfat5-regulates-downstream-osmoregulatory-proteins-during-freeze-thaw-stress-in-the-wood-frog
#19
Yichi Zhang, Rasha Al-Attar, Kenneth B Storey
Rana sylvatica, known as the wood frog, can survive extremely cold temperatures during winter by undergoing full-body freezing, where it tolerates freezing of 65-70% of its total body water. During freezing, cellular dehydration decreases damage to the cell by preventing ice crystallization. Challenged with many stresses, these animals are forced to develop physiological adaptations to osmoregulation and osmoprotection that are necessary to ensure their survival. The purpose of this study was to elucidate a potential mechanism by which the transcription factor, NFAT5, regulates the expression of three osmoregulatory proteins (aldose reductase, SMIT, and BGT-1)...
September 22, 2017: Cryobiology
https://www.readbyqxmd.com/read/28942218/characterization-of-metabolic-diffusion-and-perfusion-properties-in-gbm-contrast-enhancing-versus-non-enhancing-tumor
#20
Adam Autry, Joanna J Phillips, Stojan Maleschlijski, Ritu Roy, Annette M Molinaro, Susan M Chang, Soonmee Cha, Janine M Lupo, Sarah J Nelson
BACKGROUND: Although the contrast-enhancing (CE) lesion on T1-weighted MR images is widely used as a surrogate for glioblastoma (GBM), there are also non-enhancing regions of infiltrative tumor within the T2-weighted lesion, which elude radiologic detection. Because non-enhancing GBM (Enh-) challenges clinical patient management as latent disease, this study sought to characterize ex vivo metabolic profiles from Enh- and CE GBM (Enh+) samples, alongside histological and in vivo MR parameters, to assist in defining criteria for estimating total tumor burden...
September 21, 2017: Translational Oncology
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