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https://www.readbyqxmd.com/read/28330181/optimization-of-medium-composition-for-in-vitro-shoot-proliferation-and-growth-of-date-palm-cv-mejhoul
#1
Mouaad Amine Mazri, Reda Meziani, Jamal El Fadile, Az-Eddine Ezzinbi
The effects of major mineral salts, L-glutamine, myo-inositol and carbon source on shoot bud proliferation of date palm (Phoenix dactylifera L.) cv. Mejhoul were evaluated. Different concentrations of ammonium nitrate (NH4NO3; 550, 825 or 1650 mg/L), potassium nitrate (KNO3; 633.3, 950 or 1900 mg/L), calcium chloride dehydrate (CaCl2·2H2O; 147, 220 or 440 mg/L), potassium dihydrogen phosphate (KH2PO4; 57, 85 or 170 mg/L), magnesium sulfate heptahydrate (MgSO4·7H2O; 123, 185 or 370 mg/L), L-glutamine and myo-inositol (0...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330134/phytases-from-enterobacter-and-serratia-species-with-desirable-characteristics-for-food-and-feed-applications
#2
Harpreet Kaur Kalsi, Rajveer Singh, Harcharan Singh Dhaliwal, Vinod Kumar
Phytases are enzymes of great industrial importance with wide range of applications in animal and human nutrition. These catalyze the hydrolysis of phosphomonoester bonds in phytate, thereby releasing lower forms of myo-inositol phosphates and inorganic phosphate. Addition of phytase to plant-based foods can improve its nutritional value and increase mineral bioavailability by decreasing nutritional effect of phytate. In the present investigation, 43 phytase positive bacteria on PSM plates were isolated from different sources and characterized for phytase activity...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28327767/regioselective-sn2-reactions-for-rapid-syntheses-of-azido-inositols-by-one-pot-sequence-specific-nucleophilysis
#3
Arthi Ravi, Syed Zahid Hassan, Ajithkumar N Vanikrishna, Kana M Sureshan
Triflates of myo-inositol undergo facile solvolysis in DMSO and DMF yielding SN2 products substituted with O-nucleophiles; DMF showed slower kinetics. Axial O-triflate undergoes faster substitution than equatorial O-triflate. By exploiting this difference in kinetics, solvent-tuning and sequence-controlled nucleophilysis, rapid synthesis of three azido-inositols of myo-configuration from myo-inositol itself has been achieved.
March 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28325784/the-prevention-of-gestational-diabetes-mellitus-with-antenatal-oral-inositol-supplementation-a-randomized-controlled-trial
#4
Maria Farren, Niamh Daly, Aoife McKeating, Brendan Kinsley, Michael J Turner, Sean Daly
OBJECTIVES: This study investigated if inositol in a combination of myo-inositol and D-Chiro-inositol would prevent gestational diabetes mellitus (GDM) in women with a family history of diabetes. RESEARCH DESIGN AND METHODS: This was a randomized controlled trial that examined whether inositol from the first antenatal visit prevents GDM. The trial was carried out in a single-center tertiary referral center. Women with a family history of diabetes were enrolled at the first antenatal visit...
March 21, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28323160/effect-of-age-and-the-apoe-gene-on-metabolite-concentrations-in-the-posterior-cingulate-cortex
#5
Sana Suri, Uzay Emir, Charlotte J Stagg, Jamie Near, Ralf Mekle, Florian Schubert, Enikő Zsoldos, Abda Mahmood, Archana Singh-Manoux, Mika Kivimäki, Klaus P Ebmeier, Clare E Mackay, Nicola Filippini
Proton magnetic resonance spectroscopy ((1)H-MRS) has provided valuable information about the neurochemical profile of Alzheimer's disease (AD). However, its clinical utility has been limited in part by the lack of consistent information on how metabolite concentrations vary in the normal aging brain and in carriers of apolipoprotein E (APOE) ε4, an established risk gene for AD. We quantified metabolites within an 8cm(3) voxel within the posterior cingulate cortex (PCC)/precuneus in 30 younger (20-40 years) and 151 cognitively healthy older individuals (60-85 years)...
March 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/28320484/nutritional-intervention-preconception-and-during-pregnancy-to-maintain-healthy-glucose-metabolism-and-offspring-health-nipper-study-protocol-for-a-randomised-controlled-trial
#6
Keith M Godfrey, Wayne Cutfield, Shiao-Yng Chan, Philip N Baker, Yap-Seng Chong
BACKGROUND: Improved maternal nutrition and glycaemic control before and during pregnancy are thought to benefit the health of the mother, with consequent benefits for infant body composition and later obesity risk. Maternal insulin resistance and glycaemia around conception and in early pregnancy may be key determinants of maternal physiology and placental function, affecting fetal nutrient supply and maternal-feto-placental communications throughout gestation, with implications for later postnatal health...
March 20, 2017: Trials
https://www.readbyqxmd.com/read/28317782/assessment-of-iron-bioavailability-from-different-bread-making-processes-using-an-in-vitro-intestinal-cell-model
#7
I Rodriguez-Ramiro, C A Brearley, S F A Bruggraber, A Perfecto, P Shewry, S Fairweather-Tait
Myo-inositol hexakisphosphate (IP6), is the main iron chelator in cereals and bread. The aim of this study was to investigate the effect of three commercial baking processes (sourdough, conventional yeast and Chorleywood Bread Making Process (CBP)) on the IP6 content of wholemeal bread, its impact on iron uptake in Caco-2 cells and the predicted bioavailability of iron from these breads with added iron, simulating a mixed-meal. The sourdough process fully degraded IP6 whilst the CBP and conventional processes reduced it by 75% compared with wholemeal flour...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28304238/remote-motor-system-metabolic-profile-and-surgery-outcome-in-cervical-spondylotic-myelopathy
#8
Sorin C Craciunas, Mircea R Gorgan, Bogdan Ianosi, Phil Lee, Joseph Burris, Carmen M Cirstea
OBJECTIVE In patients with cervical spondylotic myelopathy (CSM), the motor system may undergo progressive functional/structural changes rostral to the lesion, and these changes may be associated with clinical disability. The extent to which these changes have a prognostic value in the clinical recovery after surgical treatment is not yet known. In this study, magnetic resonance spectroscopy (MRS) was used to test 2 primary hypotheses. 1) Based on evidence of corticospinal and spinocerebellar, rubro-, or reticulospinal tract degeneration/dysfunction during chronic spinal cord compression, the authors hypothesized that the metabolic profile of the primary motor cortices (M1s) and cerebellum, respectively, would be altered in patients with CSM, and these alterations would be associated with the extent of the neurological disabilities...
March 17, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28298227/metabolomics-approaches-in-pancreatic-adenocarcinoma-tumor-metabolism-profiling-predicts-clinical-outcome-of-patients
#9
S Battini, F Faitot, A Imperiale, A E Cicek, C Heimburger, G Averous, P Bachellier, I J Namer
BACKGROUND: Pancreatic adenocarcinomas (PAs) have very poor prognoses even when surgery is possible. Currently, there are no tissular biomarkers to predict long-term survival in patients with PA. The aims of this study were to (1) describe the metabolome of pancreatic parenchyma (PP) and PA, (2) determine the impact of neoadjuvant chemotherapy on PP and PA, and (3) find tissue metabolic biomarkers associated with long-term survivors, using metabolomics analysis. METHODS: (1)H high-resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy using intact tissues was applied to analyze metabolites in PP tissue samples (n = 17) and intact tumor samples (n = 106), obtained from 106 patients undergoing surgical resection for PA...
March 16, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28293260/treatment-with-myo-inositol-and-selenium-ensures-euthyroidism-in-patients-with-autoimmune-thyroiditis
#10
Maurizio Nordio, Sabrina Basciani
Clinical evidences have highlighted the efficacy of myo-inositol and selenium in the treatment of autoimmune thyroiditis. Aim of this study was to further analyze the role of myo-inositol plus selenium (Myo-Ins-Se) in restoring a normal thyroid function of Hashimoto's patients with subclinical hypothyroidism. Eighty-six patients with Hashimoto's thyroiditis having thyroid-stimulating hormone (TSH) levels between 3 and 6 mIU/L, elevated serum antithyroid peroxidase (TPOAb) and/or antithyroglobulin (TgAb), and normal free thyroxine (fT4) and free triiodothyronine (fT3) levels were enrolled in the study: one hyperthyroid subject with TSH about 0...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28290506/high-binding-affinity-of-repressor-iolr-avoids-costs-of-untimely-induction-of-myo-inositol-utilization-by-salmonella-typhimurium
#11
Jessica Hellinckx, Ralf Heermann, Angela Felsl, Thilo M Fuchs
Growth of Salmonella enterica serovar Typhimurium strain 14028 with myo-inositol (MI) is characterized by a bistable phenotype that manifests with an extraordinarily long (34 h) and variable lag phase. When cells were pre-grown in minimal medium with MI, however, the lag phase shortened drastically to eight hours, and to six hours in the absence of the regulator IolR. To unravel the molecular mechanism behind this phenomenon, we investigated this repressor in more detail. Flow cytometry analysis of the iolR promoter at a single cell level demonstrated bistability of its transcriptional activation...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28289196/osmolality-salinity-responsive-enhancers-osres-control-induction-of-osmoprotective-genes-in-euryhaline-fish
#12
Xiaodan Wang, Dietmar Kültz
Fish respond to salinity stress by transcriptional induction of many genes, but the mechanism of their osmotic regulation is unknown. We developed a reporter assay using cells derived from the brain of the tilapia Oreochromis mossambicus (OmB cells) to identify osmolality/salinity-responsive enhancers (OSREs) in the genes of Omossambicus Genomic DNA comprising the regulatory regions of two strongly salinity-induced genes, inositol monophosphatase 1 (IMPA1.1) and myo-inositol phosphate synthase (MIPS), was isolated and analyzed with dual luciferase enhancer trap reporter assays...
March 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28283543/kcnq-smit-complex-formation-facilitates-ion-channel-solute-transporter-cross-talk
#13
Daniel L Neverisky, Geoffrey W Abbott
Voltage-gated potassium channels formed by KCNQ2 and KCNQ3 are essential for normal neuronal excitability. KCNQ2/3 channel activity is augmented in vivo by phosphatidylinositol 4,5-bisphosphate (PIP2), which is generated from myo-inositol, an osmolyte transported into cells by sodium-dependent myo-inositol transporters (SMITs). Here, we discovered that KCNQ2/3 channels isoform-specifically colocalize with SMIT1 and SMIT2 at sciatic nerve nodes of Ranvier and in axon initial segments, and form channel-transporter complexes in vitro and in vivo KCNQ2/3 coexpression protected SMIT1 activity from the otherwise inhibitory effects of cellular depolarization imposed by elevating extracellular [K(+)], and KCNQ2 was required for potentiation of SMIT activity by myo-inositol preincubation...
March 10, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28277112/myo-inositol-administration-positively-effects-ovulation-induction-and-intrauterine-insemination-in-patients-with-polycystic-ovary-syndrome-a-prospective-controlled-randomized-trial
#14
Özlen Emekçi Özay, Ali Cenk Özay, Erkan Çağlıyan, Recep Emre Okyay, Bülent Gülekli
Objectıve: The aim of the study is to investigate the effect of myo-inositol (MYO) on pregnancy rates of patients diagnosed with polycystic ovary syndrome (PCOS) who undergone controlled ovulation induction and intrauterine insemination (IUI). METHODS: A total of 196 infertile patients diagnosed with PCOS and admitted to Dokuz Eylul University Faculty of Medicine were included in the study between March 2013 and May 2016. The patients in group 1 (n = 98) were given 4 g MYO and 400 μg folic acid before and during ovulation induction...
March 3, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28273858/use-of-a-pan-genomic-dna-microarray-in-determination-of-the-phylogenetic-relatedness-among-cronobacter-spp-and-its-use-as-a-data-mining-tool-to-understand-cronobacter-biology
#15
REVIEW
Ben D Tall, Jayanthi Gangiredla, Christopher J Grim, Isha R Patel, Scott A Jackson, Mark K Mammel, Mahendra H Kothary, Venugopal Sathyamoorthy, Laurenda Carter, Séamus Fanning, Carol Iversen, Franco Pagotto, Roger Stephan, Angelika Lehner, Jeffery Farber, Qiong Q Yan, Gopal R Gopinath
Cronobacter (previously known as Enterobacter sakazakii) is a genus of Gram-negative, facultatively anaerobic, oxidase-negative, catalase-positive, rod-shaped bacteria of the family Enterobacteriaceae. These organisms cause a variety of illnesses such as meningitis, necrotizing enterocolitis, and septicemia in neonates and infants, and urinary tract, wound, abscesses or surgical site infections, septicemia, and pneumonia in adults. The total gene content of 379 strains of Cronobacter spp. and taxonomically-related isolates was determined using a recently reported DNA microarray...
March 4, 2017: Microarrays
https://www.readbyqxmd.com/read/28273723/effects-of-a-72-hours-fasting-on-brain-metabolism-in-healthy-women-studied-in%C3%A2-vivo-with-magnetic-resonance-spectroscopic-imaging
#16
Xiao-Qi Ding, Andrew A Maudsley, Ulrich Schweiger, Birte Schmitz, Ralf Lichtinghagen, Stefan Bleich, Heinrich Lanfermann, Kai G Kahl
Adaptive response of human brain to stress plays a key role in maintaining health. Knowledge about how stress affects neurometabolism may help to understand adaptive stress responses, and distinguish maladaptation in neuropsychiatric disorders. In this study, neurometabolic responses to fasting stress in healthy women were investigated. Fifteen healthy females were examined for mood and cognition and using whole-brain MR spectroscopic imaging before and immediately after a 72-h fasting. Results were compared to 15 age-matched healthy females who did not taken part in fasting (non-fasting)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28268188/-1-h-nmr-based-metabolomics-reveals-neurochemical-alterations-in-the-brain-of-adolescent-rats-following-acute-methylphenidate-administration
#17
Emmanuel Quansah, Victor Ruiz-Rodado, Martin Grootveld, Fay Probert, Tyra S C Zetterström
The psychostimulant methylphenidate (MPH) is increasingly used in the treatment of attention deficit hyperactivity disorder (ADHD). While there is little evidence for common brain pathology in ADHD, some studies suggest a right hemisphere dysfunction among people diagnosed with the condition. However, in spite of the high usage of MPH in children and adolescents, its mechanism of action is poorly understood. Given that MPH blocks the neuronal transporters for dopamine and noradrenaline, most research into the effects of MPH on the brain has largely focused on these two monoamine neurotransmitter systems...
March 6, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28260722/high-resolution-magic-angle-spinning-1-h-nmr-spectroscopy-based-metabolic-profiling-of-hippocampal-tissue-in-rats-with-depression-like-symptoms
#18
Hayato Akimoto, Shinji Oshima, Kousuke Ohara, Akio Negishi, Hanako Hiroyama, Tadashi Nemoto, Daisuke Kobayashi
Depressive disorders cause large socioeconomic effects influencing not only the patients themselves but also their family and broader community as well. To better understand the physiologic factors underlying depression, in this study, we performed metabolomics analysis, an omics technique that comprehensively analyzes small molecule metabolites in biological samples. Specifically, we utilized high-resolution magic-angle spinning-(1)H NMR (HRMAS-(1)H NMR) spectroscopy to comprehensively analyze the changes in metabolites in the hippocampal tissue of rats exposed to chronic stress (CS) via multi-step principal component analysis (multi-step PCA)...
March 4, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28250348/complexes-of-myo-inositol-hexakisphosphate-ip6-with-zinc-or-lanthanum-for-the-decorporation-of-radiocesium
#19
Kazuma Ogawa, Miho Aoki, Tadahisa Fukuda, Sumi Kadono, Tatsuto Kiwada, Akira Odani
Radioactive nuclides leak into the surrounding environment after nuclear power plant disasters, such as the Chernobyl accident and the Fukushima Daiichi Nuclear Power Plant disaster. Cesium-137 ((137)Cs) (t1/2=30.1 year), a water-soluble radionuclide with a long physical half-life, contaminates aquatic ecosystems and food products. In humans, (137)Cs concentrates in muscle tissue and has a long biological half-life, indicating it may be harmful. myo-Inositol-hexakisphosphate (IP6) is a compound found in grain, beans, and oil seeds...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28243709/heterologous-production-of-kasugamycin-an-aminoglycoside-antibiotic-from-streptomyces-kasugaensis-in-streptomyces-lividans-and-rhodococcus-erythropolis-l-88-by-constitutive-expression-of-the-biosynthetic-gene-cluster
#20
Kano Kasuga, Akira Sasaki, Takashi Matsuo, Chika Yamamoto, Yuiko Minato, Naoya Kuwahara, Chikako Fujii, Masayuki Kobayashi, Hitosi Agematu, Tomohiro Tamura, Mamoru Komatsu, Jun Ishikawa, Haruo Ikeda, Ikuo Kojima
Kasugamycin (KSM), an aminoglycoside antibiotic isolated from Streptomyces kasugaensis cultures, has been used against rice blast disease for more than 50 years. We cloned the KSM biosynthetic gene (KBG) cluster from S. kasugaensis MB273-C4 and constructed three KBG cassettes (i.e., cassettes I-III) to enable heterologous production of KSM in many actinomycetes by constitutive expression of KBGs. Cassette I comprised all putative transcriptional units in the cluster, but it was placed under the control of the P neo promoter from Tn5...
February 27, 2017: Applied Microbiology and Biotechnology
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