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https://www.readbyqxmd.com/read/29475122/blue-light-irradiation-triggers-the-antimicrobial-potential-of-zno-nanoparticles-on-drug-resistant-acinetobacter-baumannii
#1
Ming-Yeh Yang, Kai-Chih Chang, Liang-Yu Chen, Po-Ching Wang, Chih-Chiang Chou, Zhong-Bin Wu, Anren Hu
Photodynamic inactivation (PDI) is a non-invasive and safe therapeutic method for microbial infections. Bacterial antibiotic resistance is caused by antibiotics abuse. Drug-resistant Acinetobacter spp. is a serious problem in hospitals around the world. These pathogens from nosocomial infections have high mortality rates in frailer people, and Acinetobacter spp. is commonly found in immunocompromised patients. Visible light is safer than ultraviolet light (UV) for PDI of nosocomial pathogens with mammalian cells...
February 6, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29474547/suicidal-ideation-and-suicide-attempts-among-women-seeking-treatment-for-substance-use-and-trauma-symptoms
#2
Stella M Resko, Sarah Kruman Mountain, Suzanne Browne, David C Kondrat, Michael Kral
Substance use disorders and posttraumatic stress disorder have been associated with suicide. Through secondary analysis of the screening data from the Women and Trauma Study conducted by the National Institute on Drug Abuse Clinical Trials Network, the present study examined rates and correlates of suicidal ideation and suicide attempts among women who sought treatment for substance use and trauma at seven outpatient substance use programs. The sample included women between the ages of 18 and 65 years (M = 39...
February 21, 2018: Health & Social Work
https://www.readbyqxmd.com/read/29474213/the-opioid-epidemic-and-the-current-prevalence-of-substance-use-disorder-in-anesthesiologists
#3
Ethan O Bryson
PURPOSE OF REVIEW: There has been a substantial increase in prescription and illicit opioid abuse in the general population observed over the last two decades. Initially fueled by an influx of prescription opioid medications, the opioid epidemic now includes increasingly potent heroin and illicit fentanyl. Younger anesthesiologists, those currently in training or recent graduates, have come of age in a society where opioid abuse is much more prevalent. RECENT FINDINGS: The current prevalence of substance use disorder (SUD) in the physician population is slightly higher than in the general population and appears to be increasing...
February 22, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29472948/craving-and-drug-reward-a-comparison-of-celecoxib-and-ibuprofen-in-detoxifying-opiate-addicts
#4
Sara Jafari, Sana Khajehpour, Emran Mohammad Razzaghi, Kazem Heidari, Mehdi Soleimani, Padideh Ghaeli
Objective: Craving for substance abuse is a usual and complicated problem in patients, with opioid addiction who are in opioid detoxifying process. Craving has been added as one of the diagnostic criteria of substance use disorders in DSM-5. The present trial aimed at comparing the effects of celecoxib versus ibuprofen in reducing pain and decreasing the desire to use opiates in patients undergoing opiate detoxification (n = 32). Method: A total of 32 patients (both inpatients and outpatients), who were undergoing opiate detoxification procedure and met the inclusion criteria entered this 4- week study...
October 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29472875/anxiety-and-depression-in-drug-dependent-patients-with-cluster-c-personality-disorders
#5
Carlos Roncero, Adelia de Miguel, Ascensión Fumero, Alfonso C Abad, Rita Martín, Juan Manuel Bethencourt, Lara Grau-López, Laia Rodríguez-Cintas, Constanza Daigre
Objective: Comorbidity between personality disorders (PD) and substance-use disorders (SUD) is one of the most common findings in the psychiatric field. The patients with Cluster C disorders present maladjustment traits often characterized by high levels of anxiety. The main aim of this study was to find evidences about higher anxiety and depression prevalence on Cluster C than others Clusters, analyzing similarities and differences within, with other Cluster A and B PD patients and patients without PD...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29472642/role-of-trace-amine-associated-receptor-1-in-nicotine-s-behavioral-and-neurochemical-effects
#6
Jian-Feng Liu, Robert Seaman, Justin N Siemian, Rohan Bhimani, Bernard Johnson, Yanan Zhang, Qing Zhu, Marius C Hoener, Jinwoo Park, David M Dietz, Jun-Xu Li
Nicotine addiction and abuse remains a global health issue. To date, the fundamental neurobiological mechanism of nicotine addiction remains incompletely understood. Trace amine-associated receptor 1 (TAAR1) is thought to directly modulate dopaminergic system and are thought to be a neural substrate underlying addictive-like behaviors. We aimed to investigate the role of TAAR1 in nicotine addictive-like behaviors. TAAR1 expression after nicotine treatment was evaluated by western blotting. c-Fos immunofluorescence and in vivo fast-scan cyclic voltammetry were used to examine the activation of brain regions and dopamine release, respectively...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29472071/prediction-of-collision-cross-section-and-retention-time-for-broad-scope-screening-in-gradient-reversed-phase-liquid-chromatography-ion-mobility-high-resolution-accurate-mass-spectrometry
#7
Christian Brinch Mollerup, Marie Mardal, Petur Weihe Dalsgaard, Kristian Linnet, Leon Patrick Barron
Exact mass, retention time (RT), and collision cross section (CCS) are used as identification parameters in liquid chromatography coupled to ion mobility high resolution accurate mass spectrometry (LC-IM-HRMS). Targeted screening analyses are now more flexible and can be expanded for suspect and non-targeted screening. These allow for tentative identification of new compounds, and in-silico predicted reference values are used for improving confidence and filtering false-positive identifications. In this work, predictions of both RT and CCS values are performed with machine learning using artificial neural networks (ANNs)...
February 15, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29471926/do-benefits-restrictions-limit-medicaid-acceptance-in-addiction-treatment-results-from-a-national-study
#8
Christina M Andrews, Colleen M Grogan, Melissa A Westlake, Amanda J Abraham, Harold A Pollack, Thomas A D'Aunno, Peter D Friedmann
OBJECTIVE: To assess the relationship of restrictions on Medicaid benefits for addiction treatment to Medicaid acceptance among addiction treatment programs. DATA SOURCES: We collected primary data from the 2013-2014 wave of the National Drug Abuse Treatment System Survey. STUDY DESIGN: We created two measures of benefits restrictiveness. In the first, we calculated the number of addiction treatment services covered by each state Medicaid program...
April 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29470605/considering-the-context-social-factors-in-responses-to-drugs-in-humans
#9
REVIEW
Harriet de Wit, Michael Sayette
BACKGROUND: Drugs are typically used in social settings. Here, we consider two factors that may contribute to this observation: (i) the presence of other people may enhance the positive mood effects of a drug, and conversely, (ii) drugs may enhance the value of social stimuli. METHODS: We review evidence from controlled laboratory studies with human volunteers, which investigated either of these interactions between social factors and responses to drugs. We examine the bidirectional effects of social stimuli and single doses of alcohol, stimulants, opioids, and cannabis...
February 22, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29470436/neurobiology-of-propofol-addiction-and-supportive-evidence-what-is-the-new-development
#10
REVIEW
Ming Xiong, Nimisha Shiwalkar, Kavya Reddy, Peter Shin, Alex Bekker
Propofol is a short-acting intravenous anesthetic agent suitable for induction and maintenance of general anesthesia as well as for procedural and intensive care unit sedation. As such it has become an unparalleled anesthetic agent of choice in many institutional and office practices. However, in addition to its idealistic properties as an anesthetic agent, there is accumulating evidence suggesting its potential for abuse. Clinical and experimental evidence has revealed that not only does propofol have the potential to be abused, but also that addiction to propofol shows a high mortality rate...
February 22, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29469962/apremilast-alters-behavioral-responses-to-ethanol-in-mice-i-reduced-ethanol-consumption-and-preference
#11
Yuri A Blednov, Adriana J Da Costa, Tamara Tarbox, Olga Ponomareva, Robert O Messing, R Adron Harris
BACKGROUND: Phosphodiesterase type 4 (PDE4) inhibitors produce widespread anti-inflammatory effects and reduce ethanol consumption in several rodent models. These drugs are potential treatments for several diseases, including central nervous system disorders, but clinical use is limited by their emetic activity. Apremilast is a selective PDE4 inhibitor with fewer gastrointestinal side effects that is FDA approved for the treatment of psoriasis. METHODS: We measured the acute and chronic effects of apremilast on ethanol consumption in male and female C57BL/6J mice using the continuous and intermittent 24-h two-bottle choice drinking models...
February 22, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29469591/associations-of-health-insurance-coverage-mental-health-problems-and-drug-use-with-mental-health-service-use-in-us-adults-an-analysis-of-2013-national-survey-on-drug-use-and-health
#12
Nianyang Wang, Xin Xie
OBJECTIVE: To estimate the prevalence of mental health service use among US adults, examine the associations of mental health service use with health insurance coverage, mental health problems and drug use, and detect health disparities. METHODS: This was a cross-sectional study with 5,434 adults receiving mental health service out of 37,424 adult respondents from the 2013 National Survey on Drug Use and Health. Weighted univariate and multiple logistic regression analyses were used to estimate the associations of potential factors with mental health service use...
February 22, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29468294/behavioral-phenotyping-and-dopamine-dynamics-in-mice-with-conditional-deletion-of-the-glutamate-transporter-glt-1-in-neurons-resistance-to-the-acute-locomotor-effects-of-amphetamine
#13
Kathryn D Fischer, Alex C W Houston, Rajeev I Desai, Michelle R Doyle, Jack Bergman, Maha Mian, Rebekah Mannix, David L Sulzer, Se Joon Choi, Eugene V Mosharov, Nathaniel W Hodgson, Anita Bechtholt, Klaus A Miczek, Paul A Rosenberg
RATIONALE: GLT-1 is the major glutamate transporter in the brain and is expressed predominantly in astrocytes but is also present in excitatory axon terminals. To understand the functional significance of GLT-1 expressed in neurons, we generated a conditional GLT-1 knockout mouse and inactivated GLT-1 in neurons using Cre-recombinase expressed under the synapsin 1 promoter, (synGLT-1 KO). OBJECTIVES: Abnormalities of glutamate homeostasis have been shown to affect hippocampal-related behaviors including learning and memory as well as responses to drugs of abuse...
February 22, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29467662/purinergic-signaling-in-neuron-astrocyte-interactions-circadian-rhythms-and-alcohol-use-disorder
#14
REVIEW
Daniel Lindberg, Lindsey Andres-Beck, Yun-Fang Jia, Seungwoo Kang, Doo-Sup Choi
Alcohol use disorder (AUD) is a debilitating condition marked by cyclic patterns of craving, use, and withdrawal. These pathological behaviors are mediated by multiple neurotransmitter systems utilizing glutamate, GABA, dopamine, ATP, and adenosine. In particular, purines such as ATP and adenosine have been demonstrated to alter the phase and function of the circadian clock and are reciprocally regulated by the clock itself. Importantly, chronic ethanol intake has been demonstrated to disrupt the molecular circadian clock and is associated with altered circadian patterns of activity and sleep...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29466956/outcome-and-prognostic-factors-of-patients-with-right-sided-infective-endocarditis-requiring-intensive-care-unit-admission
#15
Hugues Georges, Olivier Leroy, Norair Airapetian, Nicolas Lamblin, Elie Zogheib, Patrick Devos, Sebastien Preau
BACKGROUND: Right-sided infective endocarditis (RSIE) is an uncommon diagnosis accounting for less than 10% of cases of infective endocarditis. Optimal management for severely ill patients with RSIE remains challenging because few studies reported on management and outcome. The goal of our study was to determine outcome and associated prognostic factors in a population of ICU patients with a diagnosis of definite, active and severe RSIE. METHODS: We performed a retrospective study in 10 French ICUs between January 2002 and December 2012...
February 21, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29464791/comparing-pharmacological-treatments-for-cocaine-dependence-incorporation-of-methods-for-enhancing-generalizability-in-meta-analytic-studies
#16
Ryoko Susukida, Rosa M Crum, Hwanhee Hong, Elizabeth A Stuart, Ramin Mojtabai
OBJECTIVES: Few head-to-head comparisons of cocaine dependence medications exist, and combining data from different randomized controlled trials (RCTs) is fraught with methodological challenges including limited generalizability of the RCT findings. This study applied a novel meta-analytic approach to data of cocaine dependence medications. METHODS: Data from 4 placebo-controlled RCTs (Reserpine, Modafinil, Buspirone, and Ondansetron) were obtained from the National Institute of Drug Abuse Clinical Trials Network (n = 456)...
February 21, 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29462108/disulfiram-attenuates-morphine-or-methadone-withdrawal-syndrome-in-mice
#17
Anna de Cordé, Paweł Krząścik, Renata Wolińska, Patrycja Kleczkowska, Małgorzata Filip, Magdalena Bujalska-Zadrożny
Taking opioids is often accompanied by the development of dependence. Unfortunately, treatment of opioid dependence is difficult, particularly because of codependence - for example, on alcohol or other drugs of abuse. In the presented study, we analyzed the potential influence of disulfiram, a drug used to aid the management of alcoholism, on opioid abstinence syndrome, which occurs as a result of opioid withdrawal. Opioid dependence in mice was induced by subcutaneous administration of either morphine or methadone at a dose of 48 mg/kg for 10 consecutive days...
February 16, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29461948/case-251-nontraumatic-drug-associated-rhabdomyolysis-of-head-and-neck-muscles
#18
Alexandre Debelmas, Déborah Benchetrit, Damien Galanaud, Roman H Khonsari
History A 21-year-old man with a history of abuse of multiple drugs and mild cognitive impairment who initially underwent treatment for excited delirium developed respiratory arrest shortly after admission and was successfully resuscitated. Unenhanced computed tomography (CT) of the head and neck and contrast material-enhanced CT of the chest, abdomen, pelvis, and complete spine were performed shortly after the initial treatment. Head and neck magnetic resonance (MR) imaging was performed 24 hours after admission...
March 2018: Radiology
https://www.readbyqxmd.com/read/29461553/current-state-of-bioanalytical-chromatography-in-clinical-analysis
#19
REVIEW
H Kočová Vlčková, V Pilařová, P Svobodová, J Plíšek, F Švec, L Nováková
Chromatographic methods have become popular in clinical analysis in both routine and research laboratories. The purpose of this review article is to provide an overview of the current state of chromatographic methods, i.e., high-performance liquid chromatography (HPLC), gas chromatography (GC), and supercritical fluid chromatography (SFC), in clinical analysis. The aspects related to method sensitivity, selectivity, analysis time, and throughput have been discussed in detail. Adequate solutions to improve these features have also been presented...
February 20, 2018: Analyst
https://www.readbyqxmd.com/read/29460153/gaba-and-glutamate-synaptic-coadaptations-to-chronic-ethanol-in-the-striatum
#20
Verginia C Cuzon Carlson
Alcohol (ethanol) is a widely used and abused drug with approximately 90% of adults over the age of 18 consuming alcohol at some point in their lifetime. Alcohol exerts its actions through multiple neurotransmitter systems within the brain, most notably the GABAergic and glutamatergic systems. Alcohol's actions on GABAergic and glutamatergic neurotransmission have been suggested to underlie the acute behavioral effects of ethanol. The striatum is the primary input nucleus of the basal ganglia that plays a role in motor and reward systems...
February 20, 2018: Handbook of Experimental Pharmacology
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