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Paola Saracco, Rossana Bagna, Chiara Gentilomo, Mariella Magarotto, Alice Viano, Federica Magnetti, Paola Giordano, Matteo Luciani, Angelo Claudio Molinari, Agnese Suppiej, Luca Antonio Ramenghi, Paolo Simioni
OBJECTIVE: To evaluate clinical data and associated risk conditions of noncerebral systemic venous thromboembolism (VT), arterial thromboembolism (AT), and intracardiac thromboembolism (ICT) in neonates. STUDY DESIGN: Data analysis of first systemic thromboembolism occurring in 75 live neonates (0-28 days), enrolled in the Italian Registry of Pediatric Thrombosis from neonatology centers between January 2007 and July 2013. RESULTS: Among 75 events, 41 (55%) were VT, 22 (29%) AT, and 12 (16%) ICT; males represented 65%, and 71% were preterm...
April 2016: Journal of Pediatrics
Fatma Yildirim, İskender Kara, Hızır Okuyan, Adnan Abaci, Melda Turkoglu, Gülbin Aygencel
A 54-year-old man had undergone to percutaneous coronary intervention (PCI) and two stents were placed to left anterior coronary artery and circumflex artery. Low molecular weight heparin (LMWH) together with ticagrelor 90 mg twice a day and acetylsalicylic acid (Aspirin) were started after PCI due to high risk of stent trombosis. On the fourth day of patient's follow-up in the intensive care unit (ICU), bloody secretion was started from endotracheal tube. Hemoglobin dropping, bilateral infiltration on the chest X-ray and bleeding from lung were diagnosed as diffuse alveolar hemorrhage (DAH)...
January 19, 2016: Clinical Respiratory Journal
Ramón Montes, Elisabet Guruceaga, José R González-Porras, Joan C Reverter, Pascual Marco, Elena Pina, José A Páramo, José Hermida, Ramón Lecumberri
OBJECTIVE: The aim of this study was to assess differences in the gene expression profile of peripheral blood cells between patients with early recurrent thrombosis vs. patients without recurrent events after withdrawal of anticoagulant therapy for a first episode of unprovoked deep vein thrombosis (uDVT), to identify novel predictors of recurrence. METHODS: In the discovery population (N = 32), a microarray RNA assay followed by RT-PCR confirmation were performed...
August 2016: European Journal of Haematology
Agnese Suppiej, Chiara Gentilomo, Paola Saracco, Stefano Sartori, Manuela Agostini, Rossana Bagna, Bianca Bassi, Paola Giordano, Massimo Grassi, Andrea Guzzetta, Donatella Lasagni, Matteo Luciani, Angelo C Molinari, Antonella Palmieri, Maria Caterina Putti, Luca Antonelli Ramenghi, Lidia Luciana Rota, Domenico Sperlì, Anna Maria Laverda, Paolo Simioni
Data from large case series of children with cerebral thrombotic events are pivotal to improve prevention, early recognition and treatment of these conditions. The Italian Registry of Pediatric Thrombosis (R. I. T. I.) was established in 2007 by a multidisciplinary team, aiming for a better understanding of neonatal and paediatric thrombotic events in Italy and providing a preliminary source of data for the future development of specific clinical trials and diagnostic-therapeutic protocols. We analysed data relative to the paediatric cerebral thrombotic events of the R...
June 2015: Thrombosis and Haemostasis
A F Vanin, L V Adamian, E N Burgova, N A Tkachev
Exogenous dinitrosyl iron complexes (DNIC) with thiol-containing ligands as NO and NO+ donors are capable of exerting both regulatory and cytotoxic effects on diverse biological processes similarly to those characteristic of endogenous nitric oxide. Regulatory activity of DNIC (vasodilation, hypotension, trombosis suppression, red blood cell elasticity increasing, skin wound healing acceleration, penile erection inducing, etc) is determined by their capacity of NO and NO+ transfer to biological targets of the latter (hemo- and thiol-containing proteins, respectively) due to higher affinity of the proteins for NO and NO+ than that of DNIC...
July 2014: Biofizika
Juan G Córdoba-Soriano, Rishi Puri, Ignacio Amat-Santos, Henrique B Ribeiro, Omar Abdul-Jawad Altisent, María del Trigo, Jean-Michel Paradis, Eric Dumont, Marina Urena, Josep Rodés-Cabau
INTRODUCTION AND OBJECTIVES: Despite the rapid global uptake of transcatheter aortic valve implantation, valve trombosis has yet to be systematically evaluated in this field. The aim of this study was to determine the clinical characteristics, diagnostic criteria, and treatment outcomes of patients diagnosed with valve thrombosis following transcatheter aortic valve implantation through a systematic review of published data. METHODS: Literature published between 2002 and 2012 on valve thrombosis as a complication of transcatheter aortic valve implantation was identified through a systematic electronic search...
March 2015: Revista Española de Cardiología
Juan Carlos Hernández Boluda
No abstract text is available yet for this article.
March 15, 2015: Medicina Clínica
Carlos Grande García, Rafael Martínez Martínez, David Valcarcel Ferreiras
No abstract text is available yet for this article.
November 7, 2014: Medicina Clínica
Z Jabiry-Zieniewicz, F A Dabrowski, B Suchońska, R Kowalczyk, E Nowacka, B Kociszewska-Najman, B Pietrzak, P Malkowski, M Wielgos
AIM: Retrospective analysis of the course of pregnancy, labor and mode of anesthesia in women with portal hypertension and esophageal varices induced by portal vein thrombosis. MATERIAL: From 2000 to 2012 seven pregnant were admitted. None had liver transplantation (Ltx), the varicose have been in the 1st stage. Each of them has been consulted by the obstetrician, transplant surgeon and anesthetist. The patient condition during pregnancy, labor and postpartum period was analyzed...
January 2015: Journal of Maternal-fetal & Neonatal Medicine
E Alegria-Barrero, N Foin, A C Lindsay, M Paulo, P Hei Chan, D Syrseloudis, N Viceconte, R Martos, K Beatt, C Di Mario
Although provisional T-stenting with stenting of the main branch and optional side branch stenting is nowadays the default strategy generally preferred for simple bifurcation lesions, percutaneous coronary intervention (PCI) of complex true bifurcation lesions remains a difficult task to achieve also with modern second generation drug eluting stents. Treatment of complex bifurcational lesions is not only more time consuming but can lead to significantly higher rate of periprocedural myocardial infarction and late estenosis, stent thrombosis and target lesion revascularization...
October 2013: Minerva Cardioangiologica
Jose R Gonzalez-Porras, Fernando Escalante, Emilia Pardal, Magdalena Sierra, Luis J Garcia-Frade, Santiago Redondo, Maryam Arefi, Carlos Aguilar, Fernando Ortega, Erik de Cabo, Rosa M Fisac, Oscar Sanz, Carmen Esteban, Ignacio Alberca, Mercedes Sanchez-Barba, Maria T Santos, Abel Fernandez, Tomas J Gonzalez-Lopez
AIM: Few studies specifically focus on elderly splenectomized immune thrombocytopenia (ITP) patients. Older patients with ITP and excellent health are often excluded from surgery splenectomy. We aimed to compare the safety and efficacy of splenectomy in elderly and non-elderly ITP patients and to examine the effect of age on therapeutic response. MATERIAL AND METHODS: We carried out a retrospective analysis of a series of 218 patients who had undergone splenectomy for ITP...
September 2013: European Journal of Haematology
A P Trevizol, A I David, E T Yamashita, R A Pecora, L A D'Albuquerque
BACKGROUND: Intestinal/multivisceral transplantation (IT/MVT) is the gold standard treatment for patients with intestinal failure and complications related to total parenteral nutrition, gastrointestinal inoperable indolent tumors, or diffuse portal trombosis. Currently, the reported 1-year patient survival rate is around 80%, similar to other solid organ abdominal transplantations. Unfortunately, the patient survival decreases after the first year with the 5-year rate not close to 70% yet...
April 2013: Transplantation Proceedings
Luis A Ramón, Aitana Braza-Boïls, Juan Gilabert, Melitina Chirivella, Francisco España, Amparo Estellés, Juan Gilabert-Estellés
STUDY QUESTION: Which is the role of microRNAs (miRNAs) related to several angiogenesis regulators such as VEGF-A (Vascular endothelial growth factor-A) and TSP-1 (Thrombospondin-1) in endometrial cancer? SUMMARY ANSWER: A dysregulated expression of miRNAs related to angiogenesis and an increase in the VEGF-A levels were observed in endometrial cancer in comparison with control. The different expression of miRNAs could modulate the expression of angiogenic and antiangiogenic factors, which may play an important role in the pathogenesis of endometrial cancer...
October 2012: Human Reproduction
N Al Hajjar, D Crişan, M Grigorescu, P Boruah
Liver abscess is a rare complication of sigmoid diverticulitis and must be considered within the differential diagnosis. We report a case of a male patient, age 42, admitted to our hospital with chief complaints of a dull pain in upper right abdominal quadrant, fever, weakness, diarrhoea and weight loss of approximately 3 weeks duration. Physical examination on initial work-up revealed tenderness on palpation in upper right abdomen, and left iliac fosa and a 39 degrees C fever. Biochemistry showed marked inflammatory syndrome, leukocitosis, increased level of platelets, altered liver function...
March 2012: Chirurgia
L Voltolini, C Rapicetta, L Luzzi, P Paladini, C Ghiribelli, S Scolletta, M Fineschi, G Gotti
AIM: Recent studies have reported a high incidence of perioperative in-stent trombosis with myocardial infarction (MI), in patients undergoing non-cardiac surgery, early after coronary angioplasty and stenting. The short and long-term results of surgery for non-small cell lung cancer (NSCLC) after prophylatic coronary angioplasty and stenting were analyzed. METHODS: Prospective collected data were examined for postoperative complications and long-term survival in 16 consecutive patients who underwent mayor lung resection for NSCLC after prophylactic coronary angioplasty and stenting for significant coronary artery disease , from 2001 to 2008...
February 2012: Minerva Chirurgica
José Ramón de Berrazueta Fernández
Acute Coronary Syndrome (ACS) are classified by the mechanisms of thrombosis that induce the complete of partial occlusion of coronary artery, with two tipes of ST changes in ECG. ACS with ST segment elevation (ACSSTE) is induced by a completed thrombotic occlusion by a red thrombus, it need a rapid and complete restoration of coronary artery blood flow with myocardial reperfusion in the first six hours after starting with pain. This is the mechanism by which reperfusion therapy reduces morbidity and mortality...
2010: Anales de la Real Academia Nacional de Medicina
B Graupera, M A Pascual, P Garcia, R Di Paola, B Ubeda, F Tresserra
Ovarian vein trombosis (OVT) is a pathologic entity classically considered as a postpartum complication and only rarely associated with other diseases. Due to its vague symptoms, it is usually underdiagnosed. However its consequences can be fatal. We report a case of an incidental finding of ovarian thrombosis in an asymptomatic 45-year-old woman who underwent surgery due to the ultrasonographic finding of a para-ovarian cyst.
2011: European Journal of Gynaecological Oncology
Roberto Martín-Reyes, Santiago Jiménez-Valero, Felipe Navarro, Raúl Moreno
We present the case report of a patient presenting with ST segment elevation myocardial infarction due to a subacute drug-eluting stent trombosis within the proximal segment of the left circumflex artery (LCX). Six days before a total chronic occlusion was treated at the mid segment of the LCX by overlapping two drug-eluting stents. Optical coherence tomography (OCT) was helpful to demonstrate stent underexpansion of the overlaping segment as the main mechanism of early stent thrombosis. This case is illustrative about the potential role of OCT to identify the mechanisms of ST and thus guiding the PCI procedure...
2011: Case Reports in Medicine
M P Snijders, M Morsink, D J van Spronsen, I M de Kievit-van der Heijden
Primary malignant lymphoma involving the ovaries is extremely rare. We present a unique case of a primary Non-Hodgkin's lymphoma (NHL) of both ovaries, preceded by an internal jugular vein trombosis (IJVT) as paraneoplastic syndrome. Currently, 36 months after surgical treatment of this FIGO Stage Ib, Ann Arbor Stage 2E NHL, the patient is clinically free of disease. Based on this case and a review of the literature it is concluded that paraneoplastic syndromes like spontaneous IJVT should prompt the clinician to make a thorough diagnostic work-up in search of an underlying malignancy, including the female genital tract...
2010: European Journal of Gynaecological Oncology
José M de la Torre Hernández, Fernando Alfonso, Federico Gimeno, Jose A Diarte, Ramón Lopez-Palop, Armando Pérez de Prado, Fernando Rivero, Juan Sanchis, Mariano Larman, Jose F Diaz, Jaime Elizaga, Javier Martín Moreiras, Alfredo Gomez Jaume, José M Hernández, Josepa Mauri, Angel Sánchez Recalde, Juan A Bullones, Jose R Rumoroso, Bruno García Del Blanco, Jose A Baz, Francisco Bosa, Javier Botas, Felipe Hernández
OBJECTIVES: This study sought to evaluate second-generation drug-eluting stent (DES) thrombosis in clinical practice. BACKGROUND: First-generation DES are associated with a significant incidence of late thrombosis. There is paucity of data regarding real practice late thrombosis incidence and predictors with second-generation DES, zotarolimus-eluting stent (ZES), and everolimus-eluting stents (EES). METHODS: A prospective, large-scale, non-industry-linked multicenter registry was designed...
September 2010: JACC. Cardiovascular Interventions
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