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seroprevalence and dengue

Vikram Londhey, Sachee Agrawal, Nilima Vaidya, Seema Kini, J S Shastri, Sujatha Sunil
INTRODUCTION: There have been various studies from India describing the acute presentation and the long-term sequalae of Chikungunya (CHIKV) infection. However, there are very few studies discussing the Chikungunya-Dengue (DENV) co-infection from Western India. The present project was undertaken to study the clinical features of Dengue and Chikungunya co-infection and compare with Chikungunya mono-infection; correlate the clinical findings with seroprevalence and molecular identification of Dengue and Chikungunya using IgM ELISA and RTPCR...
March 2016: Journal of the Association of Physicians of India
Cheng Hoon Chew, Yuan Liang Woon, Faridah Amin, Tassha H Adnan, Asmah Hani Abdul Wahab, Zul Edzhar Ahmad, Mohd Adam Bujang, Abdul Muneer Abdul Hamid, Rahman Jamal, Wei Seng Chen, Chee Peng Hor, Lena Yeap, Ling Ping Hoo, Pik Pin Goh, Teck Onn Lim
BACKGROUND: Each year an estimated 390 million dengue infections occur worldwide. In Malaysia, dengue is a growing public health concern but estimate of its disease burden remains uncertain. We compared the urban-rural difference of dengue seroprevalence and determined age-specific dengue seroprevalence in Malaysia. METHODS: We undertook analysis on 11,821 subjects from six seroprevalence surveys conducted in Malaysia between 2001 and 2013, which composed of five urban and two rural series...
2016: BMC Public Health
Natsuko Imai, Ilaria Dorigatti, Simon Cauchemez, Neil M Ferguson
BACKGROUND: Despite being the most widely distributed mosquito-borne viral infection, estimates of dengue transmission intensity and associated burden remain ambiguous. With advances in the development of novel control measures, obtaining robust estimates of average dengue transmission intensity is key for assessing the burden of disease and the likely impact of interventions. METHODOLOGY/PRINCIPLE FINDINGS: We estimated the force of infection (λ) and corresponding basic reproduction numbers (R0) by fitting catalytic models to age-stratified incidence data identified from the literature...
July 2016: PLoS Neglected Tropical Diseases
Lata Baswanna Galate, Sachee R Agrawal, Jayanthi S Shastri, Vikram Londhey
BACKGROUND: Chikungunya fever (CHIK) is an arboviral disease. Dengue fever (DENG) and CHIK are indistinguishable clinically and need to be differentiated by laboratory investigations. PURPOSE: This study aimed at estimating the seroprevalence of CHIK mono-infection and CHIK and DENG dual infection in suspected patients. We also analyzed the age, sex distribution, joint involvement, and relation of joint movement restriction with visual analog scale (VAS). MATERIALS AND METHODS: Two hundred patients clinically suspected with DENG and CHIK were enrolled from a Tertiary Care Hospital in Mumbai from April 2012 to October 2013...
July 2016: Journal of Laboratory Physicians
Usa Thisyakorn, Kanyalak Srettakraikul, Marisa Hemungkorn, Chule Thisyakorn
BACKGROUND: Dengue infection is the most common arboviral infection in the world while the HIV/AIDS epidemic remains a global concern. The pathogenesis of both diseases is rather on the contrary and it is generally observed that dengue diseases are uncommon in children with AIDS. OBJECTIVE: To study the seroprevalence of dengue virus infection in HIV-infected children compared to healthy children. MATERIAL AND METHOD: A cross-sectional seroprevalence of dengue virus was conducted at King Chulalongkorn Memorial Hospital, Bangkok, Thailand...
February 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Thomas J Hladish, Carl A B Pearson, Dennis L Chao, Diana Patricia Rojas, Gabriel L Recchia, Héctor Gómez-Dantés, M Elizabeth Halloran, Juliet R C Pulliam, Ira M Longini
Dengue vaccines will soon provide a new tool for reducing dengue disease, but the effectiveness of widespread vaccination campaigns has not yet been determined. We developed an agent-based dengue model representing movement of and transmission dynamics among people and mosquitoes in Yucatán, Mexico, and simulated various vaccine scenarios to evaluate effectiveness under those conditions. This model includes detailed spatial representation of the Yucatán population, including the location and movement of 1...
May 2016: PLoS Neglected Tropical Diseases
Chuan Hun Ding, Zetti Zainol Rashid, Md Mostafizur Rahman, NanFeng Khang, Wan Ngor Low, Nurabrar Hussin, Melissa Iqlima Marzuki, Alyaa Nadhira Jaafar, Nurul Ain' Nabilla Roslan, Terukumar Chandrasekaran
OBJECTIVES: The aims of this study were to determine the seroprevalence of acute dengue in Universiti Kebangsaan Malaysia (UKM) Medical Centre and its correlation with selected haematological and biochemical parameters. METHODS: This cross-sectional study was conducted from January to June 2015. A patient was serologically diagnosed with acute dengue if the dengue virus IgG, IgM or NS-1 antigen was reactive. RESULTS: Out of 1,774 patients suspected to have acute dengue, 1,153 were serologically diagnosed with the infection, resulting in a seroprevalence of 64...
March 2016: Pakistan Journal of Medical Sciences Quarterly
Bradford D Gessner, Annelies Wilder-Smith
BACKGROUND: To evaluate the potential public health impact of the live attenuated tetravalent Sanofi Pasteur dengue vaccine (CYD-TDV) we analyzed data from the reported clinical trials to calculate vaccine preventable disease incidence (VPDI) and number needed to vaccinate (NNV) based on the licensure indication for persons age 9 years and above. METHODS: VPDI is defined as incidence in an unvaccinated population X vaccine efficacy (VE), and thus incorporates both VE and the underlying burden of disease...
April 29, 2016: Vaccine
S N Mohsin, F Ghafoor, M Saleem, R Ghous, M Aasim
Dengue has become a global problem in past few decades, with half of the world's population at risk of infection. For some countries of Asia and Latin America, severe dengue is a major cause of serious illness and even death in children. Pakistan has been reported as a hyperendemic area for dengue infection. Our study aimed to find seroprevalence of past dengue infection in asymptomatic children of Lahore with no previous history of dengue infection. A total of 400 samples were collected from children aged 1-12 years in Lahore using random sampling...
August 2016: Epidemiology and Infection
Yenny Pereira, Margarita Samudio, Andrea Ojeda, Águeda Cabello
BACKGROUND: Dengue is an infection of great global importance with different clinical presentations. OBJECTIVE: To establish the seroprevalence of infection by the dengue virus in a district of the Paraguayan Chaco. MATERIAL AND METHODS: Cross-sectional study in 418 inhabitants of three villages in the district of Villa Hayes, Paraguay, using a probabilistic household sampling, a questionnaire and blood sampling. Antibodies were determined by the ELISA capture IgG anti dengue method and factors associated with seroprevalence were evaluated...
December 2015: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Ghazi A Jamjoom, Esam I Azhar, Moujahid A Kao, Raja M Radadi
BACKGROUND: Although virologically confirmed dengue fever has been recognized in Jeddah, Saudi Arabia, since 1994, causing yearly outbreaks, no proper seroepidemiologic studies on dengue virus have been conducted in this region. Such studies can define the extent of infection by this virus and estimate the proportion that may result in disease. The aim of this study was to measure the seroprevalence of past dengue virus infection in healthy Saudi nationals from different areas in the city of Jeddah and to investigate demographic and environmental factors that may increase exposure to infection...
2016: Virology: Research and Treatment
Julian Justin Gabor, Norbert Georg Schwarz, Meral Esen, Peter Gottfried Kremsner, Martin Peter Grobusch
BACKGROUND: Apart from outbreak reports, little is known about the endemicity of dengue and chikungunya virus in African countries. We investigated serum samples collected in Gabon before major outbreaks in 2007 and 2010 in order to identify pre-outbreak-circulation of both viruses. METHODS: Serum samples from Gabonese infants (162) were analyzed at 3, 9, 15 and 30 months of age by commercial ELISA for dengue and chikungunya IgG-antibodies. If samples were positive medical records of participants were analyzed for symptoms concordant with dengue and chikungunya infections during the time period of assumed seroconversion...
January 2016: Travel Medicine and Infectious Disease
Maria Theresa Alera, Anon Srikiatkhachorn, John Mark Velasco, Ilya A Tac-An, Catherine B Lago, Hannah E Clapham, Stefan Fernandez, Jens W Levy, Butsaya Thaisomboonsuk, Chonticha Klungthong, Louis R Macareo, Ananda Nisalak, Laura Hermann, Daisy Villa, In-Kyu Yoon
BACKGROUND: The mean age of dengue has been increasing in some but not all countries. We sought to determine the incidence of dengue virus (DENV) infection in adults and children in a prospective cohort study in the Philippines where dengue is hyperendemic. METHODOLOGY/PRINCIPAL FINDINGS: A prospective cohort of subjects ≥6 months old in Cebu City, Philippines, underwent active community-based surveillance for acute febrile illnesses by weekly contact. Fever history within the prior seven days was evaluated with an acute illness visit followed by 2, 5, and 8-day, and 3-week convalescent visits...
February 2016: PLoS Neglected Tropical Diseases
Maite Aubry, Jérôme Finke, Anita Teissier, Claudine Roche, Julien Broult, Sylvie Paulous, Philippe Desprès, Van-Mai Cao-Lormeau, Didier Musso
OBJECTIVES: French Polynesia is a high epidemic/endemic area for arthropod-borne viruses (arboviruses). We recently reported the silent circulation of Ross River virus and absence of active transmission of chikungunya virus (CHIKV) among blood donors sampled before the emergence of Zika virus (ZIKV) and CHIKV in French Polynesia. In this study, the prevalence of the four serotypes of dengue virus (DENV) and the occurrence of circulation of other arboviruses were investigated in blood donors in French Polynesia...
December 2015: International Journal of Infectious Diseases: IJID
James V Conlan, Khamphouth Vongxay, Boualam Khamlome, Richard G Jarman, Robert V Gibbons, Stanley G Fenwick, R C A Thompson, Stuart D Blacksell
A total of 1,136 samples from 289 households in four provinces in northern Laos were subjected to Japanese encephalitis virus (JEV) and dengue virus hemagglutination inhibition (DENV HI). Overall, antibodies to JEV were detected by HI in 620 (54.6%) of 1,136 people; of which 217 (19.1%) had HI activity against JEV only. Antibodies to DENV4 were detected by HI in 526 (46.3%) of 1,136 people; of which 124 (10.9%) had HI activity against DENV4 only. Antibodies to DENV1-3 were detected by HI in 296 (26.1%), 274 (24...
November 2015: American Journal of Tropical Medicine and Hygiene
Munirah Mohd Shukri, Kai Ling Kho, Masoumeh Ghane Kisomi, Rafidah Lani, Suria Marlina, Siti Fatimah Muhd Radzi, Sun Tee Tay, Li Ping Wong, Awang Bulgiba Awang Mahmud, Quaza Nizamuddin Hassan Nizam, Sazaly Abu Bakar, Keivan Zandi
BACKGROUND: Tick-borne encephalitis virus (TBEV) and Crimean-Congo haemorrhagic fever virus (CCHFV) are important tick-borne viruses. Despite their wide geographical distribution and ease of acquisition, the prevalence of both viruses in Malaysia is still unknown. This study was conducted to determine the seroprevalence for TBEV and CCHFV among Malaysian farm workers as a high-risk group within the population. METHODS: We gave questionnaires to 209 farm workers and invited them to participate in the study...
2015: BMC Public Health
Isabel Rodríguez-Barraquer, Sunil S Solomon, Periaswamy Kuganantham, Aylur Kailasom Srikrishnan, Canjeevaram K Vasudevan, Syed H Iqbal, Pachamuthu Balakrishnan, Suniti Solomon, Shruti H Mehta, Derek A T Cummings
BACKGROUND: Dengue and chikungunya are rapidly expanding viruses transmitted by mosquitoes of the genus Aedes. Few epidemiological studies have examined the extent of transmission of these infections in South India despite an increase in the number of reported cases, and a high suitability for transmission. METHODS AND FINDINGS: We conducted a household-based seroprevalence survey among 1010 individuals aged 5-40 years living in fifty randomly selected spatial locations in Chennai, Tamil Nadu...
2015: PLoS Neglected Tropical Diseases
Caroline Ochieng, Petronella Ahenda, Amy Y Vittor, Raymond Nyoka, Stella Gikunju, Cyrus Wachira, Lilian Waiboci, Mamo Umuro, Andrea A Kim, Leonard Nderitu, Bonventure Juma, Joel M Montgomery, Robert F Breiman, Barry Fields
Arthropod-borne viruses are a major constituent of emerging infectious diseases worldwide, but limited data are available on the prevalence, distribution, and risk factors for transmission in Kenya and East Africa. In this study, we used 1,091 HIV-negative blood specimens from the 2007 Kenya AIDS Indicator Survey (KAIS 2007) to test for the presence of IgG antibodies to dengue virus (DENV), chikungunya virus (CHIKV) and Rift Valley fever virus (RVFV).The KAIS 2007 was a national population-based survey conducted by the Government of Kenya to provide comprehensive information needed to address the HIV/AIDS epidemic...
2015: PloS One
Alok Kumar, Anders L Nielsen
Long-term seroprevalence studies of dengue have provided a measure of the degree of endemicity and future trends in disease prevalence and severity. In this study, we describe the seroprevalence of dengue antibodies in febrile persons with suspected acute dengue in Barbados. It is a retrospective population-based study of all febrile persons with suspected dengue from 2006 to 2013. All of the cases had IgM and IgG antibodies in the blood sample drawn between days 3 and 5 of their illness. Among the 8296 cases that were tested for IgM antibodies, 3037 (36...
November 2015: Journal of Infection and Public Health
K Laoprasopwattana, T Suntharasaj, P Petmanee, O Suddeaugrai, A Geater
Limited information is available on the seroprevalence of chikungunya virus (CHIKV) infection and maternal-fetal transmission incidence of CHIKV and dengue virus (DENV) infections during the 2008-2009 CHIKV outbreak in southern Thailand. A community-based post-epidemic seroprevalence study was conducted in parturient women admitted to the Thepa District Hospital in Songkhla Province, Thailand, for delivery from November 2009 to May 2010. The women were tested for chikungunya (CHIK) IgM/IgG and dengue (DEN) IgM/IgG...
January 2016: Epidemiology and Infection
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