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Marie Chinazzo, Gérard Lorette, Robert Baran, Antoine Finon, Élie Saliba, Annabel Maruani
INTRODUCTION: The anatomy and embryology of the nail are well known, and nail abnormalities are a feature of many genodermatoses. However, the physiological aspect is not well described. We aimed to analyse the physiological features of nails in healthy newborns. METHODS: We performed an observational, prospective study at University Hospital Center of Tours between July and October 2015. Newborns were included by a dermatologist assistant during the systematic examination on release of the mother from the hospital...
September 23, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Ilteris Oguz Topal, Sule Gungor, Ozgur Emek Kocaturk, Hatice Duman, Mustafa Durmuscan
BACKGROUND: Vitiligo is an acquired pigmentary skin disorder affecting 0.1-4% of the general population. The nails may be affected in patients with an autoimmune disease such as psoriasis, and in those with alopecia areata. It has been suggested that nail abnormalities should be apparent in vitiligo patients. OBJECTIVE: We sought to document the frequency and clinical presentation of nail abnormalities in vitiligo patients compared to healthy volunteers. We also examined the correlations between nail abnormalities and various clinical parameters...
July 2016: Anais Brasileiros de Dermatologia
Miriam Reverter, Scott C Cutmore, Rodney Bray, Thomas H Cribb, Pierre Sasal
We studied the monogenean communities of 34 species of butterflyfish from the tropical Indo-West Pacific, identifying 13 dactylogyrid species (including two species that are presently undescribed). Monogenean assemblages differed significantly between host species in terms of taxonomic structure, intensity and prevalence. Parasite richness ranged from 0 (Chaetodon lunulatus) to 11 (C. auriga, C. citrinellus and C. lunula). Host specificity varied between the dactylogyrids species, being found on 2-29 of the 34 chaetodontid species examined...
October 2016: Parasitology
Meltem Gursu, Sami Uzun, Derya Topcuoğlu, Leyli Kadriye Koc, Lamiye Yucel, Abdullah Sumnu, Egemen Cebeci, Oktay Ozkan, Ahmet Behlul, Leyla Koc, Savas Ozturk, Rumeyza Kazancioglu
AIM: To examine all skin changes in peritoneal dialysis (PD) patients followed up in our unit. METHODS: Patients on PD program for at least three months without any known chronic skin disease were included in the study. Patients with already diagnosed skin disease, those who have systemic diseases that may cause skin lesions, patients with malignancies and those who did not give informed consent were excluded from the study. All patients were examined by the same predetermined dermatologist with all findings recorded...
July 6, 2016: World Journal of Nephrology
Kamia Punia, Michael Bucaro, Andrew Mancuso, Christina Cuttitta, Alexandra Marsillo, Alexey Bykov, William L'Amoreaux, Krishnaswami S Raja
The classic chemical garden experiment is reconstructed to produce protein-intercalated silicate-phosphate tubules that resemble tubular sponges. The constructs were synthesized by seeding calcium chloride into a solution of sodium silicate-potassium phosphate and gelatin. Sponge-mimetic tubules were fabricated with varying percentages of gelatin (0-15% w/v), in diameters ranging from 200 μm to 2 mm, characterized morphologically and compositionally, functionalized with biomolecules for cell adhesion, and evaluated for cytocompatibility...
August 30, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
O Figueroa-Silva, A Vicente, A Agudo, C Baliu-Piqué, S Gómez-Armayones, M J Aldunce-Soto, E J Inarejos Clemente, M Navallas Irujo, D Gutiérrez de la Iglesia, M A González-Enseñat
BACKGROUND: Nail-patella syndrome (NPS) is an inherited disease produced by mutations in the LMX1B gene. It is characterized by fingernail dysplasia, hypoplastic or absent patella, dysplasia of the elbows and iliac horns on X-ray. It is useful to know this syndrome since some patients develop nephropathy and eye abnormalities. There are very few accurate descriptions related to this syndrome in the literature. OBJECTIVE: Describe the features of 11 patients with NPS in a paediatric hospital...
September 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Miglena Komforti, Maria A Selim, Jane S Bellet
Cutaneous leiomyomata, which are benign smooth muscle neoplasms, commonly present as dermal-based nodules or papules with smooth borders and firm consistency. Digital, particularly subungual leiomyomata are quite rare. A 16-year-old female presented to nail clinic complaining of discoloration of the lunula of the left thumbnail for 2.5 months. On initial examination, a pink longitudinal band was present in the center of the nail plate, with yellow discoloration and distal onycholysis. The patient had only mild tenderness with firm palpation, and did not recall trauma of the area...
April 2016: Journal of Cutaneous Pathology
Kyle J Fetters, David M Costello, Chad R Hammerschmidt, G Allen Burton
Sediments in navigation-dominated waterways frequently are contaminated with a variety of particle-associated pollutants and are subject to frequent short-term resuspension events. There is little information documenting whether resuspension of metal-contaminated sediments has adverse ecological effects on resident aquatic organisms. Using a novel laboratory approach, the authors examined the mobilization of Zn, Cu, Cd, Pb, Ni, and Cr during resuspension of 1 freshwater and 2 coastal marine sediments and whether resuspension and redeposition resulted in toxicity to model organisms...
March 2016: Environmental Toxicology and Chemistry
Nilton Di Chiacchio, Julio Cesar Jasso-Olivares, Nilton Gioia Di Chiacchio, José Antonio Jacinto, Maria Victoria Suárez Restrepo
The Iso-Kikuchi Syndrome is a rare condition characterized by nail dysplasia involving the index fingers, including micronychia, polyonychia, anonychia, irregular lunula, malalignment and hemionychogryphosis. On the antero-posterior image, radiologic examination reveals a narrowing of the distal phalanx. The lateral image shows a Y-shaped bifurcation of the distal phalanx. We report a case of a patient with typical clinical and radiologic signs of Iso-Kikuchi Syndrome.
May 2015: Anais Brasileiros de Dermatologia
Akram Beheshti, Malihe Charkhchian, Amir Abdollah Zangivand, Afsaneh Sedighi, Golnoosh Amri
UNLABELLED: Introduction. Patients with chronic kidney disease on hemodialysis (HD) undergo many dermatological signs and symptoms during treatment. The aim of this study was to investigate the prevalence of skin manifestations among the patients on maintenance HD in the HD center of Boo Ali-Sina Hospital (Qazvin, Iran) and compare them with the general population. METHODS: From June 2012 to July 2012 a case-controlled study was performed with 149 patients with end-stage renal disease undergoing regular HD (HD group) and 150 individuals who were randomly selected (control group) from healthy hospital staff at Boo Ali-Sina Hospital...
March 2013: Wounds: a Compendium of Clinical Research and Practice
J Choo, B Sparks, M Kasdan, B Wilhelmi
OBJECTIVE: We report a case in which an avulsion-amputation of the thumb proximal to the lunula was repaired by reattaching the amputated segment as a composite graft. The graft demonstrated complete survival with only a minimal sacrifice in length. METHODS: A 23-year-old man presented 4 hours after an avulsion injury of the thumb with associated distal and proximal phalanx fractures. The amputated segment included the sterile and germinal matrix. He underwent defatting and composite grafting of the amputated segment followed by K-wire fixation of his proximal phalanx fracture...
2015: Eplasty
Eshini Perera, Rodney Sinclair
"Nails protect the fingertips and toes. Diseases affecting the nail can cause cosmetic disfigurement and social embarrassment. Physical functioning may be impaired. Disorders of the nail bed may cause pain or create difficulty grasping fine objects. The nail bed is the area beneath the nail plate between the lunula and the hyponychium. Disorders of the nail bed can cause onycholysis, subungual hyperkeratosis, and/or onychogryphosis. Ventral pterygium is less common. Tumors of the nail bed are rare and commonly missed...
April 2015: Dermatologic Clinics
Benoit Tesson, Michael I Latz
Cells are sophisticated integrators of mechanical stimuli that lead to physiological, biochemical, and genetic responses. The bioluminescence of dinoflagellates, alveolate protists that use light emission for predator defense, serves as a rapid noninvasive whole-cell reporter of mechanosensitivity. In this study, we used atomic force microscopy (AFM) to explore the relationship between cell mechanical properties and mechanosensitivity in live cells of the dinoflagellate Pyrocystis lunula. Cell stiffness was 0...
March 24, 2015: Biophysical Journal
Matthew K Sandre, Sherry Rohekar, Lyn Guenther
BACKGROUND: Nail changes are common in psoriatic arthritis (PsA), with varying relationships existing between skin, nail, and joint disease. OBJECTIVE: To further characterize relationships between nail changes, psoriasis, and joint involvement in PsA patients. METHODS: One hundred eighty-eight PsA patients had skin, fingernail, and rheumatological assessments completed. Hand and fingernail photographs were taken and reviewed by a dermatologist...
July 2015: Journal of Cutaneous Medicine and Surgery
Robert Baran
Psoriasis is an inherited chronic hyper proliferative autoimmune disease. Nail involvement is common and is found in 61% of cases of cutaneous psoriasis, with lifetime incidence of 90%; 80 to 90% in patients with psoriatic arthritis. Classical manifestations on the nail apparatus are correlated with the origin site of the disease. The proximal matrix produces pitting, trachyonychia and Beau's lines, transverse grooves. The distal matrix (lunula) may appear spotted or erythematous in color. Inflammation of the mid or distal matrix causes leuconychia due to nail incorporation of parakeratotic cells...
November 2014: La Presse Médicale
Robert Baran
For those interested in nails, a fairly good knowledge of the anatomy of the nail unit is indispensable. But nothing will replace a careful, clinical examination of the nail apparatus. The shape of the nail, surface abnormalities and coloration, with or without a magnifying glass, may well provide a medical diagnosis not only in dermatology but also for medicine in general. Pits on the surface of the nail plate may be enough to diagnose psoriasis on a limited area of scalp dandruff. Even partial detachment of the nail apparatus might lead to the suspicion of psoriatic arthritis...
November 2014: La Presse Médicale
Imane Elmansour, Soumia Chiheb, Hakima Benchikhi
The objective is to identify nail unit changes associated with connective tissue diseases (CTD) and evaluate their frequency. We carried a prospective study between March 2012 and March2013 in our department. All patients with CTD were included. A clinical examination of the fingernails was done by the same dermatologist. Nail features were noted and classified and photos taken. Thirty nine patients were enrolled including: 16 systemic sclerosis, 14 lupus erythematosus (SLE), 8 dermatomyositis (DM), 1 primary Sjorgen's syndrome...
2014: Pan African Medical Journal
Moetaz El-Domyati, Hossam Abdel-Wahab, Eman Abdel-Azim
BACKGROUND: The nail unit is an important part of cosmetic appearance of an individual. Older people are at an increased risk of nail alterations, including normal age-related changes and disorders that more commonly affect this specific population. OBJECTIVES: To identify and evaluate the age-related nail changes and disorders in Egyptian elderly people both clinically and histopathologically. PATIENTS/METHODS: A total of 400 adult subjects, not complaining from any dermatological disease, were included in the present study; half of them were elderly of 60 years and above (elderly group)...
December 2014: Journal of Cosmetic Dermatology
J Ofaiche, A Chauvel, O Cogrel
BACKGROUND: Glomangiomas are benign vascular tumours. They are usually multiple, painless and extradigital. Herein we report a case of a solitary subungual glomangioma. PATIENTS AND METHODS: This 65-year-old woman presented with a history of bluish, asymptomatic, subungual lesions located in the lunula of her right thumb. Surgical exploration by a transungual approach showed a large bluish, well-circumscribed tumour, which was completely excised. Histological examination revealed numerous dilated blood vessels surrounded by aggregates of glomus cells, which was consistent with the diagnosis of glomangioma...
October 2014: Annales de Dermatologie et de Vénéréologie
Hina Shaikh Lal
A 55-year-old woman on treatment with capecitabine and paclitaxel for breast carcinoma presented with history of a tingling sensation in her hands and feet with a progressive burning sensation. She also noted discomfort, minimal pain and stiffness while holding objects. On examination, there was patchy hyperpigmentation of both the palms and soles, and the dorsa of hands and feet. This was accompanied by a thickening of the skin more over the knuckles and toes. In addition there was a moist desquamation around the toes and over the palmar creases and a bluish discoloration of the lunulae of both thumbnails...
September 2014: Indian Journal of Dermatology, Venereology and Leprology
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