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https://www.readbyqxmd.com/read/29149546/the-photophysical-and-photoacoustic-properties-of-quadrupolar-borondifluoride-curcuminoid-dyes
#1
Stephanie Bellinger, Maryam Hatamimoslehabadi, Seema Bag, Farha Mithila, Jeffrey La, Mathieu Frennete, Samir Laoui, David Szalda, Chandra Yelleswarapu, Jonathan Rochford
The synthesis and characterization of a series of donor-π-acceptor-π-donor (D-A-D) curcuminoid molecules are here presented incorporating π-extended aryl and electron-donating amino terminal functionalization. Computational evaluation shows these molecules possess quadrupolar character with the lowest energy transitions displaying high molar extinction coefficients with broad tunability through manipulation of terminal donating groups. Consistent with their quadrupolar nature, these molecules show varying degrees of solvatochromic behavior in both their absorption and emission spectra which has been analyzed by Lippert-Mataga and Kamlet-Taft analysis...
November 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29142199/sensorfret-a-standardless-approach-to-measuring-pixel-based-spectral-bleed-through-and-fret-efficiency-using-spectral-imaging
#2
Paul T Arsenovic, Carl R Mayer, Daniel E Conway
Fluorescence microscopy of FRET-based biosensors allow nanoscale interactions to be probed in living cells. This paper describes a novel approach to spectrally resolved fluorescence microscopy, termed sensorFRET, that enables quantitative measurement of FRET efficiency. This approach is an improvement on existing methods (FLIM, sRET, luxFRET, pFRET), as it does not require single fluorophore standards to be measured with every experiment and the acquisition is intensity independent, allowing the laser power to be optimized for varying levels of fluorophore expression...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141834/successful-treatment-of-hereditary-haemorrhagic-telangiectasia-using-595-nm-pulsed-dye-laser
#3
Junko Nishikawa, Norikazu Fujii, Takeshi Kato, Toshihiro Tanaka, Noriki Fujimoto
No abstract text is available yet for this article.
November 15, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29141064/port-wine-stains-a-focused-review-on-their-management
#4
Katelyn Mariko Updyke, Amor Khachemoune
<p>Port-wine stain (PWS) is the second most common congenital vascular malformation characterized as ectatic capillaries and venules in the dermis that clinically appears as a deep red to purple patch on the skin. Typically, PWS progressively darken and may become hypertrophic or nodular without treatment. There are several treatment options available for PWS from topical antiangiogenic agents to laser therapies. Vascular-specific lasers are the gold standard in treating PWS and classically pulsed dye lasers are usually the treatment of choice...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29141059/a-retrospective-study-on-efficacy-of-pulsed-dye-laser-and-intense-pulsed-light-for-the-treatment-of-facial-telangiectasia
#5
Lin Gao, Ni Gao, Wenting Song, Erle Dang, Rong Yin, Li Wang, Gang Wang
<p>Both pulsed dye laser (PDL) and intense pulsed light (IPL) systems have been demonstrated to be effective for treatment of facial telangiectasia, however there have been very few comparative studies between both treatments involving purely Asian patient populations. In this study, we performed a retrospective analysis to compare the efficacy of PDL and IPL systems for the treatment of facial telangiectasia. A total of 416 patients with facial telangiectasia who were treated by PDL or IPLs in our department from August 2012 to March 2015 were included in this study...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29140861/sealing-of-corneal-lacerations-using-photoactivated-rose-bengal-dye-and-amniotic-membrane
#6
Timothy A Soeken, Hong Zhu, Sheri DeMartelaere, Brett W Davies, Mirang Kim, Heuy-Ching Wang, James Aden, Rose Grimm, Clemens Alt, Irene E Kochevar, Anthony J Johnson
PURPOSE: Watertight closure of perforating corneoscleral lacerations is necessary to prevent epithelial ingrowth, infection, and potential loss of the eye. Complex lacerations can be difficult to treat, and repair with sutures alone is often inadequate. In this study, we evaluated a potentially sutureless technology for sealing complex corneal and scleral lacerations that bonds the amniotic membrane (AM) to the wound using only green light and rose bengal dye. METHODS: The AM was impregnated with rose bengal and then sealed over lacerations using green light to bond the AM to the deepithelialized corneal surface...
November 14, 2017: Cornea
https://www.readbyqxmd.com/read/29138987/optimized-ciclopirox-based-eudragit-rlpo-nail-lacquer-effect-of-endopeptidase-enzyme-as-permeation-enhancer-on-transungual-drug-delivery-and-efficiency-against-onychomycosis
#7
Abeer Khattab, Samia Shalaby
The aims of our investigation were to develop and optimize ciclopirox (CPX) nail lacquer using nonbiodegradable Eudragit RLPO (E-RLPO) as a film former and to assess its penetration efficiency across the human nail plate. Preliminary trials such as hydration enhancement factor (HEF), a retained drug in the nail plate, and SEM were studied to select the optimized permeation enhancer to be incorporated in the optimized lacquer formulation. A 3(3) full factorial design was built up to study the effect of three different factors, concentration of E-RLPO (10, 20, and 30%), Tween 80 (0...
November 14, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29138594/prevention-and-treatment-of-acute-and-chronic-radiodermatitis
#8
Sophie Seité, René-Jean Bensadoun, Jean-Michel Mazer
More than half the number of patients with cancer, who are treated with radiotherapy, will have radiodermatitis at some point during their treatment. Radiodermatitis either occurs early on in the treatment period or appears months or up to several years later. Acute radiodermatitis is a burn injury that varies in severity according to both treatment and inherent patient factors. Most acute radiodermatitis reactions resolve after several weeks but some reactions persist and can cause complications. Late-onset radiodermatitis is characterized by telangiectasia that forms on atrophic and fragile skin...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29133967/comparison-of-marginal-microleakage-of-flowable-composite-restorations-in-primary-canine-teeth-prepared-with-high-speed-diamond-bur-er-yag-laser-and-er-cr-ysgg-laser
#9
Beheshteh Malekafzali, Mohammad Asnaashari, Fateme Javadi
Background and Objectives: Adhesive restorations have become highly popular in pediatric dentistry, and novel methods of cavity preparation with minimal patient discomfort including Er:YAG and Er,Cr:YSGG laser preparations have greatly advanced. This study aimed to compare the microleakage of composite restorations of class V cavities prepared in primary canine teeth with high-speed bur and Er:YAG and Er,Cr:YSGG lasers. Materials and Methods: This in vitro study was conducted on 30 class V cavities prepared on the buccal surfaces of primary canine teeth in three groups (n = 10) of bur preparation, Er:YAG laser and Er,Cr:YSGG laser...
September 30, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29131184/two-dimensional-coherent-random-laser-in-photonic-crystal-fiber-with-dye-doped-nematic-liquid-crystal
#10
Yusuke Nagai, Chen Shao-Chieh, Kotaro Kajikawa
A random laser of a photonic crystal fiber (PCF) with holes filled with laser dye-doped nematic liquid crystal (NLC) is reported. When the excitation polarization was along the PCF axis, the measured laser threshold was 80  μJ/mm(2) per pulse, which is much lower than the previously reported random laser of PCF filled with laser dye-doped organic solvent. This low threshold is due to the high refractive index of the NLC, which produces a greater scattering efficiency. In contrast, when the excitation polarization is perpendicular to the PCF axis, the threshold was much higher or the laser oscillation was absent...
November 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29130888/co-delivery-of-cisplatin-and-cjm-126-via-photothermal-conversion-nanoparticles-for-enhanced-synergistic-antitumor-efficacy
#11
Chaoqun You, Hongshuai Wu, Mingxin Wang, Zhiguo Gao, Xiangyang Zhang, Baiwang Sun
Polymeric biomaterials that can be smartly disassembled through the cleavage of the covalent bonds in a controllable method upon an environmental stimuli such as pH change, redox, special enzymes, temperature, ultrasound as well as light irradiation but otherwise are stable under physiological condition has attracted great attention in past decades. In our study, a novel NIR-responsive targeted binary-drug loaded nanoparticles encapsulating ICG dye was prepared as a new co-delivery and combined therapy vehicle...
November 13, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29130364/fluorescent-labeling-and-2-photon-imaging-of-mouse-tooth-pulp-nociceptors
#12
A Kadala, P Sotelo-Hitschfeld, Z Ahmad, P Tripal, B Schmid, A Mueller, L Bernal, Z Winter, S Brauchi, U Lohbauer, K Messlinger, J K Lennerz, K Zimmermann
Retrograde fluorescent labeling of dental primary afferent neurons (DPANs) has been described in rats through crystalline fluorescent DiI, while in the mouse, this technique was achieved with only Fluoro-Gold, a neurotoxic fluorescent dye with membrane penetration characteristics superior to the carbocyanine dyes. We reevaluated this technique in the rat with the aim to transfer it to the mouse because comprehensive physiologic studies require access to the mouse as a model organism. Using conventional immunohistochemistry, we assessed in rats and mice the speed of axonal dye transport from the application site to the trigeminal ganglion, the numbers of stained DPANs, and the fluorescence intensity via 1) conventional crystalline DiI and 2) a novel DiI formulation with improved penetration properties and staining efficiency...
November 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29129832/multiphoton-minimal-inertia-scanning-for-fast-acquisition-of-neural-activity-signals
#13
Renaud Schuck, Mary Ann Go, Stefania Garasto, Stephanie Reynolds, Pier Luigi Dragotti, Simon Schultz
OBJECTIVE: Multi-photon laser scanning microscopy provides a powerful tool for monitoring the spatiotemporal dynamics of neural circuit activity. It is, however, intrinsically a point scanning technique. Standard raster scanning enables imaging at subcellular resolution; however, acquisition rates are limited by the size of the field of view to be scanned. Recently developed scanning strategies such as Travelling Salesman Scanning (TSS) have been developed to maximize cellular sampling rate by scanning only select regions in the field of view corresponding to locations of interest such as somata...
November 13, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29125493/validation-of-ultrasensitive-mutant-huntingtin-detection-in-human-cerebrospinal-fluid-by-single-molecule-counting-immunoassay
#14
Valentina Fodale, Roberto Boggio, Manuel Daldin, Cristina Cariulo, Maria Carolina Spiezia, Lauren Mary Byrne, Blair R Leavitt, Edward Wild, Douglas Macdonald, Andreas Weiss, Alberto Bresciani
BACKGROUND: The measurement of disease-relevant biomarkers has become a major component of clinical trial design, but in the absence of rigorous clinical and analytical validation of detection methodology, interpretation of results may be misleading. In Huntington's disease (HD), measurement of the concentration of mutant huntingtin protein (mHTT) in cerebrospinal fluid (CSF) of patients may serve as both a disease progression biomarker and a pharmacodynamic readout for HTT-lowering therapeutic approaches...
November 9, 2017: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/29123392/self-assembled-albumin-nanoparticles-for-combination-therapy-in-prostate-cancer
#15
Huibo Lian, Jinhui Wu, Yiqiao Hu, Hongqian Guo
Resistance to regular treatment strategies is a big challenge in the treatment of castration-resistant prostate cancer. Combination of photothermal and photodynamic therapy (PTT/PDT) with chemotherapy offers unique advantages over monotherapy alone. However, free drugs, such as photosensitizers and chemotherapeutic agents, lack tumor-targeted accumulation and can be easily eliminated from the body. Moreover, most of the PTT drugs are hydrophobic and their organic solvents have in vivo toxicity, thereby limiting their potential in clinical translation...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29120818/near-infrared-dye-conjugated-oxidative-stress-amplifying-polymer-micelles-for-dual-imaging-and-synergistic-anticancer-phototherapy
#16
Wonseok Yang, Joungyoun Noh, Hoyeon Park, Sian Gwon, Berwin Singh, Chulgyu Song, Dongwon Lee
The recent advances in nanotechnology have led to the development of smart nanomaterials that combine diagnostic and therapeutic functions and provide synergistic anticancer effects through the combination of different treatment modalities. Here, we report a promising theranostic nanoconstruct that can translate into multiple functionalities: fluorescence/photoacoustic imaging, acid-triggered generation of ROS (reactive oxygen species), heat and singlet oxygen production under near infrared (NIR) laser irradiation, and coupling oxidative anticancer therapy to dual imaging-guided photothermal/photodynamic therapy...
October 27, 2017: Biomaterials
https://www.readbyqxmd.com/read/29116401/elucidation-of-rubber-biosynthesis-and-accumulation-in-the-rubber-producing-shrub-guayule-parthenium-argentatum-gray
#17
Hiroyuki Kajiura, Nobuaki Suzuki, Hiroshi Mouri, Norie Watanabe, Yoshihisa Nakazawa
Guayule biosynthesizes and accumulates rubber particles predominantly in epithelial cells in the parenchyma tissue, and this biosynthesis and accumulation is accompanied by remodeling of the roles of epithelial cells. The mechanism underlying the biosynthesis and accumulation of large quantities of rubber particles and resin in the parenchyma tissue of the stem bark of guayule (Parthenium argentatum Gray) remained unanswered up to now. Here, we focused on rubber particle biosynthesis and accumulation in guayule and performed histochemical analyses using a lipophilic fluorescent dye specific for lipids and spectral confocal laser scanning microscopy...
November 7, 2017: Planta
https://www.readbyqxmd.com/read/29112179/green-ultrasound-versus-conventional-synthesis-and-characterization-of-specific-task-pyridinium-ionic-liquid-hydrazones-tethering-fluorinated-counter-anions-novel-inhibitors-of-fungal-ergosterol-biosynthesis
#18
Nadjet Rezki, Salsabeel A Al-Sodies, Sheikh Shreaz, Rayees Ahmad Shiekh, Mouslim Messali, Vaseem Raja, Mohamed R Aouad
A series of specific task ionic liquids (ILs) based on a pyridiniumhydrazone scaffold in combination with hexafluorophosphate (PF₆(-)), tetrafluoroboron (BF₄(-)) and/or trifluoroacetate (CF₃COO(-)) counter anion, were designed and characterized by IR, NMR and mass spectrometry. The reactions were conducted under both conventional and green ultrasound procedures. The antifungal potential of the synthesized compounds 2-25 was investigated against 40 strains of Candida (four standard and 36 clinical isolates)...
November 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29110458/simultaneous-rayleigh-mie-and-raman-fluorescence-characterization-of-molecularly-functionalized-colloids-by-correlative-single-particle-real-time-imaging-in-suspension
#19
Jörg Wissler, Martin Wehmeyer, Sandra Bäcker, Shirley K Knauer, Sebastian Schlücker
Many applications of nano- and microparticles require molecular functionalization. Assessing the heterogeneity of a colloidal sample in terms of its molecular functionalization is highly desirable, but not accessible by conventional ensemble experiments. Retrieving this information necessitates single-particle experiments which simultaneously detect both functionalized and non-functionalized particles via two separate imaging channels. In this contribution, we present an optical setup for performing correlative single-particle imaging using laser light-sheet illumination: the first detection channel records elastic light scattering (Rayleigh/Mie), while the second channel detects inelastic light scattering (Raman) or fluorescence...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29097290/in-vitro-evaluation-of-methylene-blue-removal-from-root-canal-after-photodynamic-therapy
#20
Karen Müller Ramalho, Sandra Ribeiro Cunha, Eric Mayer-Santos, Carlos de Paula Eduardo, Patricia Moreira de Freitas, Ana Cecilia Correa Aranha, Cacio Moura-Netto
In Endodontics, photosensitizers' such as methylene blue and toluidine blue have been used in photodynamic therapy due to their positive results. However, they can stain the dentin from the root canal after Photodynamic Therapy (PDT). The present in vitro study aimed to evaluate different stain removal protocols from root canal after PDT using methylene blue (MB) dye. After mechanical preparation of the root canal of 40 uni-radicular human teeth, PDT was performed using 0,01% MB with parameters of 3minutes of pre-irradiation and a diode laser irradiation emitting at 660nm, 40mW, 4minutes, 9...
October 30, 2017: Photodiagnosis and Photodynamic Therapy
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