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https://www.readbyqxmd.com/read/28338214/light-therapies-for-acne-abridged-cochrane-systematic-review-including-grade-assessments
#1
REVIEW
J Barbaric, R Abbott, P Posadzki, M Car, L H Gunn, A M Layton, A Majeed, J Car
We undertook a Cochrane review of randomized controlled trials (RCTs) evaluating the effects of light-based interventions for acne vulgaris. We searched the Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase, LILACS, ISI Web of Science, and grey literature sources (September 2015). We used the Grading of Recommendations Assessment, Development and Evaluation Working Group approach to assess the quality of evidence (QE). We included 71 RCTs (4211 participants, median sample size 31). Results from a single study (n = 266, low QE) showed little or no difference in effectiveness on participants' assessment of improvement between 20% aminolevulinic acid (ALA) photodynamic therapy (PDT), activated by blue light, versus vehicle plus blue light, whereas another study (n = 180) of a comparison of ALA-PDT (red light) concentrations showed 20% ALA-PDT was no more effective than 15%, but better than 10% and 5% ALA-PDT...
March 24, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28336863/a-high-power-frequency-tunable-colloidal-quantum-dot-cdse-zns-laser
#2
Saradh Prasad, Hanan Saleh AlHesseny, Mohamad S AlSalhi, Durairaj Devaraj, Vadivel Masilamai
Tunable lasers are essential for medical, engineering and basic science research studies. Most conventional solid-state lasers are capable of producing a few million laser shots, but limited to specific wavelengths, which are bulky and very expensive. Dye lasers are continuously tunable, but exhibit very poor chemical stability. As new tunable, efficient lasers are always in demand, one such laser is designed with various sized CdSe/ZnS quantum dots. They were used as a colloid in tetrahydrofuran to produce a fluorescent broadband emission from 520 nm to 630 nm...
January 30, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28335401/the-vital-dye-cdr10b-labels-the-zebrafish-mid-intestine-and-lumen
#3
Veronika Sander, Shantanu Patke, Jung Y Lee, Young-Tae Chang, Alan J Davidson
We describe the use of the fluorescent reporter compound CDr10b to label mid-intestinal structures in zebrafish larvae after simple immersion. CDr10b is deposited into the gut where it initially fills the lumen and is excreted. Using laser-mediated injury of the intestine, we show that CDr10b provides a useful readout of the integrity and repair of the epithelial cell barrier. In addition, CDr10b specifically labels the absorptive mid-intestine segment that is analogous to the mammalian small intestine. By perturbing retinoic acid signaling, which regulates the size of the mid-intestine segment, we show that CDr10b is a valuable tool to rapidly assess developmental malformations of the intestine in live animals...
March 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28335211/noise-removal-with-maintained-spatial-resolution-in-raman-images-of-cells-exposed-to-submicron-polystyrene-particles
#4
Linnea Ahlinder, Susanne Wiklund Lindström, Christian Lejon, Paul Geladi, Lars Österlund
The biodistribution of 300 nm polystyrene particles in A549 lung epithelial cells has been studied with confocal Raman spectroscopy. This is a label-free method in which particles and cells can be imaged without using dyes or fluorescent labels. The main drawback with Raman imaging is the comparatively low spatial resolution, which is aggravated in heterogeneous systems such as biological samples, which in addition often require long measurement times because of their weak Raman signal. Long measurement times may however induce laser-induced damage...
April 29, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28326794/urothelial-tumors-and-dual-band-imaging-a-new-concept-in-confocal-laser-endomicroscopy
#5
Arnaud Marien, Aurélien Rock, Khaled El Maadarani, Catherine Francois, Pierre Gosset, Brigitte Mauroy, Jean-Louis Bonnal
OBJECTIVES: Confocal laser endomicroscopy (CLE) uses a low-energy laser light source to obtain microscopic histology images of bladder tissue exposed to a fluorescent dye. To evaluate the feasibility of using CLE with two fluorophores: fluorescein (FLUO) and hexylaminolevulinate (HAL) to determine histologic and cytologic bladder cancer criteria. METHODS: Patients eligible for HAL-photodynamic diagnosis-assisted transurethral resection of bladder tumor were included...
March 22, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28321942/a-novel-water-soluble-fluorescence-probe-with-wash-free-cellular-imaging-capacity-based-on-aie-characteristics
#6
Yunxia Qian, Hongmei Liu, Haijian Tan, Qingmin Yang, Shuchen Zhang, Lingui Han, Xuegang Yi, Li Huo, Hongchi Zhao, Yonggang Wu, Libin Bai, Xinwu Ba
A potential real-time imaging water-soluble fluorescent polymer (P3) is facilely prepared via one-pot method. For P3, tetraphenylethene unit serves as the fluorescent unit, poly(acryloyl ethylene diamine) (a kind of polyelectrolyte) with specific degree of polymerization acts as water-soluble part. (1) H-NMR, gel permeation chromatography (GPC), UV-vis spectroscopy, photoluminescence (PL), and confocal laser scanning microscopy are undertaken to characterize the structure and property of P3. The results of wash-free cellular imaging show that the signal-to-noise ratio is high as the concentration of P3 is 50 μg mL(-1) ...
March 21, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28306236/hydrophobic-ir-780-dye-encapsulated-in-crgd-conjugated-solid-lipid-nanoparticles-for-nir-imaging-guided-photothermal-therapy
#7
Ye Kuang, Kunchi Zhang, Yi Cao, Xing Chen, Kewei Wang, Min Liu, Renjun Pei
It is highly demanded to improve the accumulation of NIR theranostic agents in tumor region, which is favorable to the effective phototherapy. IR-780 iodide, a near-infrared (NIR) fluorescence dye, possesses higher and more stable fluorescence intensity than clinically applied dye indocyanine green (ICG), and can be utilized in imaging-guided photothermal therapy with laser irradiation. However, lipophilicity, short circulation time and lack of targeting specificity limit its applications in cancer imaging and therapy...
March 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28299715/assessment-of-reproducibility-of-laser-electrospray-mass-spectrometry-using-electrospray-deposition-of-analyte
#8
Habiballah Sistani, Santosh Karki, Jieutonne J Archer, Fengjian Shi, Robert J Levis
A nonresonant, femtosecond (fs) laser is employed to desorb samples of Victoria blue deposited on stainless steel or indium tin oxide (ITO) slides using either electrospray deposition (ESD) or dried droplet deposition. The use of ESD resulted in uniform films of Victoria blue whereas the dried droplet method resulted in the formation of a ring pattern of the dye. Laser electrospray mass spectrometry (LEMS) measurements of the ESD-prepared films on either substrate were similar and revealed lower average relative standard deviations for measurements within-film (20...
March 15, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28298816/effect-of-gallium-arsenic-laser-on-photosensitized-periodontopathic-anaerobic-organisms-an-in-vitro-study
#9
Setu Mathur, Shaila Veerappa Kothiwale, Buddhi Prakash Nag, Tanu Mathur, Ashoka Bhansali, Rohit Kumar Khatri
BACKGROUND: The mainstay of periodontal therapy is mechanical removal of subgingival plaque. There is considerable interest in supplementing it with the use of antibiotics and antiseptics. Many drawbacks are associated with these adjunctive pharmacological regimens such as development of resistance to antibiotics and disruption of microflora of the gastrointestinal tract. Hence, alternate means of killing subgingival bacteria are clearly desirable. One such method is the use of laser...
July 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/28293023/advances-in-image-enhancement-in-colonoscopy-for-detection-of-adenomas
#10
REVIEW
Takahisa Matsuda, Akiko Ono, Masau Sekiguchi, Takahiro Fujii, Yutaka Saito
High-quality colonoscopy is mandatory to prevent adenoma recurrence and colorectal cancer. In the past few years, technical advances have been developed with the purpose of improving adenoma detection rate (ADR), one of the most important validated colonoscopy quality benchmarks. Several techniques or devices are used to optimize visualization: observation techniques; add-on devices; auxiliary imaging devices; colonoscopes with increased field of view; and colonoscopes with an integrated inflatable reusable balloon...
March 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28287601/targeted-plasma-membrane-delivery-of-a-hydrophobic-cargo-encapsulated-in-a-liquid-crystal-nanoparticle-carrier
#11
Okhil K Nag, Jawad Naciri, Eunkeu Oh, Christopher M Spillmann, James B Delehanty
The controlled delivery of drug/imaging agents to cells is critical for the development of therapeutics and for the study of cellular signaling processes. Recently, nanoparticles (NPs) have shown significant promise in the development of such delivery systems. Here, a liquid crystal NP (LCNP)-based delivery system has been employed for the controlled delivery of a water-insoluble dye, 3,3'-dioctadecyloxacarbocyanine perchlorate (DiO), from within the NP core to the hydrophobic region of a plasma membrane bilayer...
February 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28286913/laser-performance-of-some-oxazole-laser-dyes-in-restricted-matrices
#12
Mahmoud A S Sakr, Sayed A Abdel Gawad, Maram T H Abou Kana, El-Zeiny M Ebeid
This article reports the optical properties such as absorption profile, molar absorptivity, fluorescence profile and photo-physical parameters such as dipole moment, oscillator strength, fluorescence quantum yields, fluorescence lifetimes, laser performance and finally photostability of 2,5-Bis(5-tert-butyl-benzoxazol-2-yl)thiophene (BBOT),1,4-Bis(5-phenyl-2-oxazolyl)benzene (POPOB), 5-diphenyel-oxazole (PPO) laser dyes in different restricted hosts. (BBOT), (POPOB) and (PPO) are embedded in transparent silica-based nanoporous sol-gel glass and copolymer matrix of methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA)...
March 13, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28286123/the-enhancement-of-txa2-receptors-mediated-contractile-response-in-intrarenal-artery-dysfunction-in-type-2-diabetic-mice
#13
Su-Juan Kuang, Jie-Sheng Qian, Hui Yang, Fang Rao, Xiao-Yan Chen, Meng-Zhen Zhang, Zhi-Xin Shan, Qiu-Xiong Lin, Yu-Mei Xue, Shu-Lin Wu, Li Jiang, Chun-Bo Chen, Chun-Yu Deng
Thromboxane A2 (TXA2) has been implicated in the pathogenesis of diabetic vascular complications, although the underlying mechanism remains unclear. The present study investigated the alterations in TXA2 receptor signal transduction in type 2 diabetic renal arteries. The contraction of renal arterial rings in control (db/m+) mice and type 2 diabetic (db/db) mice was measured by a Multi Myograph System. Intracellular calcium concentration ([Ca(2+)]i) in vascular smooth muscle cells was measured by Fluo-4/AM dye and confocal laser scanning microscopy...
March 9, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28285560/prospective-pilot-study-on-combined-use-of-pulsed-dye-laser-and-1-topical-rapamycin-for-treatment-of-non-facial-cutaneous-capillary-malformation
#14
Eun Jin Doh, Jungyoon Ohn, Min Ji Kim, Young Gull Kim, Soyun Cho
BACKGROUND: The regeneration or revascularization of blood vessels after pulsed dye laser (PDL) treatment is one of the causes of treatment failures of cutaneous capillary malformations (CM). Recently, topical administration of rapamycin was introduced as a possible adjunctive therapeutic option to minimize post-laser revascularization in facial CM. OBJECTIVES: We evaluated the effect of combined use of 1% topical rapamycin with PDL compared to PDL alone in cutaneous CM of trunk or extremities and tried to identify the optimal duration of topical rapamycin application...
March 13, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28279918/near-infrared-light-activation-of-quenched-liposomal-ce6-for-synergistic-cancer-phototherapy-with-effective-skin-protection
#15
Liangzhu Feng, Danlei Tao, Ziliang Dong, Qian Chen, Yu Chao, Zhuang Liu, Meiwan Chen
Current photodynamic therapy (PDT) is suffering from limited efficacy towards hypoxia tumors and severe post-treatment photo-toxicity such as light-induced skin damages. To make PDT more effective in cancer treatment while being patient-comfortable, herein, a hexylamine conjugated chlorin e6 (hCe6) as the photosensitizer together with a lipophilic near-infrared (NIR) dye 1,1'-dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine iodide (DiR) are co-encapsulated into polyethylene glycol (PEG) shelled liposomes...
November 21, 2016: Biomaterials
https://www.readbyqxmd.com/read/28277002/folate-modified-indocyanine-green-loaded-lipid-polymer-hybrid-nanoparticles-for-targeted-delivery-of-cisplatin
#16
Lianshuai Gu, Tianyi Shi, Yu Sun, Chaoqun You, Senlin Wang, Gaoju Wen, Lan Chen, Xiangyang Zhang, Jin Zhu, Baiwang Sun
Cisplatin is a potent antitumor drug, which is widely applied in clinical cancer treatment. However, cisplatin can hardly distinguish between healthy tissue and tumor tissue, resulting in serious toxic side effects. Indocyanine green (ICG) is a FDA-approved near-infrared (NIR) fluorescence dye which has been used in photothermal therapy and optically mediated diagnostic, but the application of ICG is limited by its concentration-dependent aggregation, poor aqueous stability in vitro, lack of target specificity and rapid elimination from the body...
May 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28276341/rose-bengal-in-poly-2-hydroxyethyl-methacrylate-thin-films-self-quenching-by-photoactive-energy-traps
#17
Sergio D Ezquerra Riega, Hernán B Rodríguez, Enrique San Román
The effect of dye concentration on the fluorescence,ΦF, and singlet molecular oxygen,ΦΔ, quantum yields of rose bengal loaded poly(2-hydroxyethyl methacrylate) thin films (∼200 nm thick) was investigated, with the aim of understanding the effect of molecular interactions on the photophysical properties of dyes in crowded constrained environments. Films were characterized by absorption and fluorescence spectroscopy, singlet molecular oxygen ((1)O2) production was quantified using a chemical monitor, and the triplet decay was determined by laser flash-photolysis...
March 9, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28275787/-comparative-study-of-microleakage-by-using-different-finished-lines-in-selective-laser-melting-metal-crowns
#18
Yan Peng, Qun Zhong, Xue-Ying Wu, Jia-Wei Weng
PURPOSE: To evaluate microleakage of SLM Co -Cr alloy metal crown with two types finished line (chamfer and shoulder), compared with conventional fabrication of Co -Cr alloy metal crowns. METHODS: Thirty healthy non-carious human molars were selected and randomly assigned to 3 groups, 10 in each. Teeth in group A and C received a chamfer finish line preparation, whereas teeth in group C received a shoulder finish line. Conventional Co -Cr alloy metal crowns were fabricated for group A when SLM metal crowns were made for group B and group C...
December 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28275786/-effects-of-repeated-firing-on-microleakage-of-selective-laser-melting-ceramic-crowns
#19
Qun Zhong, Yan Peng, Xue-Ying Wu, Jia-Wei Weng
PURPOSE: To investigate the effects of repeated firing on microleakage of selective laser melting ceramic crowns. METHODS: Fifty molars were randomly divided into 2 groups (25 teeth in each group). Teeth in group A received a chamfer finish line preparation, whereas teeth in group B received a shoulder finish line. After SLM metal crowns were fabricated, all the crowns received initial oxidation step, opaque firing, dentin firing and glaze firing, then crowns in each group were randomly divided into 5 sub-groups according to different time of clinical firings...
December 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28274357/laser-and-light-based-treatments-of-acne-and-acne-scarring
#20
Macrene Alexiades
The treatment of acne and acne scarring with lasers and light-based and energy-based technologies has become an integral component of our therapeutic arsenal. Lasers including infrared wavelengths and pulsed dye lasers; light devices including blue light, red light, and broadband light; and photodynamic therapy with aminolevulinic acid and methylaminolevulinic acid have been shown to be effective in the treatment of acne vulgaris. The optimal outcomes are achieved with photodynamic therapy combined with medical therapy...
March 2017: Clinics in Dermatology
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