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https://www.readbyqxmd.com/read/27911476/nd-yag-and-pulsed-dye-laser-therapy-in-infantile-hemangiomas-a-retrospective-analysis-of-271-treated-hemangiomas-in-149-children
#1
F Hartmann, A Lockmann, L-L Grönemeyer, H A Haenssle, M Zutt, H von Fintel, I Kühnle, M P Schön, K-M Thoms
BACKGROUND: Infantile hemangiomas (IH) are common benign tumors in infancy. Most IH resolve spontaneously, but some require treatment due to ulceration, functional impairment or cosmetic disfiguration. While systemic propranolol is effective in many cases, laser therapy may be a safe topical alternative. OBJECTIVE: To assess the efficacy of combined Nd:YAG/pulsed dye laser (PDL) or PDL alone for therapy of IH. PATIENTS AND METHODS: 271 IH in 149 infants were treated with combined Nd:YAG/PDL or PDL alone...
December 2, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27911475/carboplatin-complexed-and-crgd-conjugated-unimolecular-nanoparticles-for-targeted-ovarian-cancer-therapy
#2
Yuyuan Wang, Liwei Wang, Guojun Chen, Shaoqin Gong
Platinum-based chemotherapy has been widely used to treat cancers including ovarian cancer; however, it suffers from dose-limiting toxicity. Judiciously designed drug nanocarriers can enhance the anticancer efficacy of platinum-based chemotherapy while reducing its systemic toxicity. Herein the authors report a stable and water-soluble unimolecular nanoparticle constructed from a hydrophilic multi-arm star block copolymer poly(amidoamine)-b-poly(aspartic acid)-b-poly(ethylene glycol) (PAMAM-PAsp-PEG) conjugated with both cRGD (cyclo(Arg-Gly-Asp-D-Phe-Cys) peptide and cyanine5 (Cy5) fluorescent dye as a platinum-based drug nanocarrier for targeted ovarian cancer therapy...
December 1, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27911358/the-rodent-model-of-nonarteritic-anterior-ischemic-optic-neuropathy-rnaion
#3
Yan Guo, Zara Mehrabian, Steven L Bernstein
Nonarteritic anterior ischemic optic neuropathy (NAION) is a focal ischemic lesion of the optic nerve that affects 1/700 individuals throughout their lifetime. NAION results in optic nerve edema, selective loss of the retinal ganglion cell neurons (RGCs) and atrophy of the optic nerve. A rodent model of NAION that expresses most NAION features and sequelae has been developed, which is applicable to both rats and mice. This model utilizes a focal laser application of 532 nm wavelength to illuminate a photoactive dye, Rose Bengal (RB), to cause capillary damage and leakage at the targeted anterior optic nerve (the laminar region)...
November 20, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27911144/comparison-of-pulsed-dye-laser-versus-combined-pulsed-dye-laser-and-nd-yag-laser-in-the-treatment-of-inflammatory-acne-vulgaris
#4
Manal Mohamed Salah El Din, Nevien Ahmed Samy, Amira Eid Salem
BACKGROUND: Both pulsed dye laser and combined 585/1,064-nm (sequential dual-wave-length PDL and Nd:YAG) laser improves inflammatory skin disorders including acne vulgaris. OBJECTIVE: To compare the efficacy of 585 nm pulsed dye laser versus sequential dual-wave-length PDL and Nd:YAG in treatment of acne vulgaris. PATIENTS AND METHOD: Thirty patients complaining of acne vulgaris were treated with a single pass of PDL alone on half of the face and a single pass of combined 585/1064-nm laser on the other half for four treatment sessions at 2 weeks interval, then assessed by the count and severity of the acne lesions & digital camera photographs Results: The study showed that inflammatory acne lesions count was significantly reduced by 82...
December 2, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27910405/high-dynamic-range-neutron-time-of-flight-detector-used-to-infer-the-d-t-n-4-he-and-d-d-n-3-he-reaction-yield-and-ion-temperature-on-omega
#5
C J Forrest, V Yu Glebov, V N Goncharov, J P Knauer, P B Radha, S P Regan, M H Romanofsky, T C Sangster, M J Shoup, C Stoeckl
Upgraded microchannel-plate-based photomultiplier tubes (MCP-PMT's) with increased stability to signal-shape linearity have been implemented on the 13.4-m neutron time-of-flight (nTOF) detector at the Omega Laser Facility. This diagnostic uses oxygenated xylene doped with diphenyloxazole C15H11NO + p-bis-(o-methylstyryl)-benzene (PPO + bis-MSB) wavelength shifting dyes and is coupled through four viewing ports to fast-gating MCP-PMT's, each with a different gain to allow one to measure the light output over a dynamic range of 1 × 10(6)...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27905610/dendritic-polyglycerol-and-n-isopropylacrylamide-based-thermoresponsive-nanogels-as-smart-carriers-for-controlled-delivery-of-drugs-through-the-hair-follicle
#6
Fitsum Feleke Sahle, Michael Giulbudagian, Julian Bergueiro, Jürgen Lademann, Marcelo Calderón
Nanoparticles with a size of several hundred nanometers can effectively penetrate into the hair follicles and may serve as depots for controlled drug delivery. However, they can neither overcome the hair follicle barrier to reach the viable cells nor release the loaded drug adequately. On the other hand, small drug molecules cannot penetrate deep into the hair follicles. Thus, the most efficient way for drug delivery through the follicular route is to employ nanoparticles that can release the drug close to the target structure upon exposure to some external or internal stimuli...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27893539/comparative-efficacy-of-radiofrequency-and-pulsed-dye-laser-in-the-treatment-of-rosacea
#7
Sue-Jeong Kim, Young Lee, Young-Joon Seo, Jeung-Hoon Lee, Myung Im
BACKGROUND: Laser and light-based therapies have been used successfully in the treatment of rosacea; however, evidence is lacking regarding the efficacy of radiofrequency (RF). OBJECTIVE: This study evaluated the efficacy of RF in the treatment of rosacea compared with pulsed dye laser (PDL). METHODS: Thirty patients with rosacea (erythematotelangiectatic rosacea [ETR], n = 20; papulopustular rosacea [PPR], n = 10) were enrolled in a randomized, controlled, split-face study...
November 23, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27879157/secondary-submucosal-vocal-cyst-following-pulsed-dye-laser-application-for-sulcus-vocalis
#8
Joo Hyun Kim, Hye Jin Hwang, Ji Hyung Kim, Min Seok Kang, Hong-Shik Choi, Hyung Kwon Byeon
CONCLUSION: Submucosal vocal cyst can occur as a distinct long-term sequelae following pulsed dye laser (PDL) application for sulcus vocalis. It is recommended that the cyst lesion should be surgically removed for treatment. Optimal and precise irradiation of PDL is considered important to avoid the development of a such complication. OBJECTIVE: After several years of clinical practice and an extended period of follow-up of the patients who received PDL application in treating sulcus vocalis, the authors have encountered several cases of secondary submucosal vocal cyst development...
November 23, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27877897/quantitative-evaluation-of-malignant-gliomas-damage-induced-by-photoactivation-of-ir700-dye
#9
Morito Sakuma, Sayaka Kita, Hideo Higuchi
The processes involved in malignant gliomas damage were quantitatively evaluated by microscopy. The near-infrared fluorescent dye IR700 that is conjugated to an anti-CD133 antibody (IR700-CD133) specifically targets malignant gliomas (U87MG) and stem cells (BT142) and is endocytosed into the cells. The gliomas are then photodamaged by the release of reactive oxygen species (ROS) and the heat induced by illumination of IR700 by a red laser, and the motility of the vesicles within these cells is altered as a result of cellular damage...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27869836/active-thermal-fine-laser-tuning-in-a-broad-spectral-range-and-optical-properties-of-cholesteric-liquid-crystal
#10
Mi-Yun Jeong, Keumcheol Kwak
In this study, we achieved active fine laser tuning in a broad spectral range with dye-doped cholesteric liquid crystal wedge-type cells through temperature control. The spatial pitch gradient of each position of the wedge cell at room temperature was almost maintained after developing a temperature gradient. To achieve the maximum tuning range, the chiral dopant concentration, thickness, thickness gradient, and temperature gradient on the wedge cell should be matched properly. In order to understand the laser tuning mechanism for temperature change, we studied the temperature dependence of optical properties of the photonic bandgap of cholesteric liquid crystals...
November 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/27869377/physical-modalities-for-the-treatment-of-rosacea
#11
Maja A Hofmann, Percy Lehmann
Rosacea is characterised by a wide variety of vascular changes. Apart from telangiectasia and erythema, often so-called flushing occurs. These vascular abnormalities can be targeted with specific light and laser devices. In addition to KTP laser, pulsed dye laser (PDL) and Nd:YAG laser, also intense pulsed light devices (IPLs) are used. The described therapeutic effects include the reduction of vascular abnormalities and even improvement of papulopustular changes. While the KTP laser shows very good results in telangiectasia, the dye laser and IPL devices are used preferably in erythema...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27868127/digital-dna-detection-based-on-a-compact-optofluidic-laser-with-ultra-low-sample-consumption
#12
Wonsuk Lee, Qiushu Chen, Xudong Fan, Dong Ki Yoon
DNA lasers self-amplify optical signals from a DNA analyte as well as thermodynamic differences between sequences, allowing quasi-digital DNA detection. However, these systems have drawbacks, such as relatively large sample consumption and complicated dye labelling. Moreover, although the lasing signal can detect the target DNA, it is superimposed on an unintended fluorescence background, which persists for non-target DNA samples as well. From an optical point of view, it is thus not truly digital detection and requires spectral analysis to identify the target...
November 21, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27866468/intratubular-disinfection-with-tri-antibiotic-and-calcium-hydroxide-pastes
#13
Thais Cristina Pereira, Layla Reginna Silva Munhoz De Vasconcelos, Marcia Sirlene Zardin Graeff, Marco Antonio Hungaro Duarte, Clóvis Monteiro Bramante, Flaviana Bombarda De Andrade
OBJECTIVE: The aim of this study was to compare the in vitro intradentinal antimicrobial ability of the calcium hydroxide and tri-antibiotic pastes. MATERIALS AND METHODS: Standard bovine dentin tubes were sterilized and then infected with Enterococcus faecalis by a new contamination protocol of great depths of dentin. The specimens were filled with the medications, divided into two test-groups: calcium hydroxide (Group 1) and tri-antibiotic (Group 2) pastes. After 15 days, the teeth were evaluated by microbiological culture and confocal laser scanning microscopy (CLSM) with viability dye assay LIVE/DEAD inside dentinal tubules...
November 21, 2016: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/27860278/key-structural-elements-of-unsymmetrical-cyanine-dyes-for-highly-sensitive-fluorescence-turn-on-dna-probe
#14
Kakishi Uno, Taeko Sasaki, Nagisa Sugimoto, Hideto Ito, Taishi Nishihara, Shinya Hagihara, Tetsuya Higashiyama, Narie Sasaki, Yoshikatsu Sato, Kenichiro Itami
Unsymmetrical cyanine dyes such as thiazole orange are useful for detecting nucleic acids with fluorescence because they dramatically enhance the fluorescence upon binding to nucleic acids. In this paper, we synthesized a series of unsymmetrical cyanine dyes and evaluated their fluorescence properties. A systematic structure-property relationship study has uncovered that the dialkylamino group at the 2-position of quinoline in a series of unsymmetrical cyanine dyes plays a critical role in the fluorescence enhancement...
November 15, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27848140/ph-effect-on-two-photon-cross-section-of-highly-fluorescent-dyes-using-femtosecond-two-photon-induced-fluorescence
#15
Krishnandu Makhal, Debabrata Goswami
Effect of solution pH on two-photon absorption cross-section of highly fluorescent Coumarin and Rhodamine dyes with high repetition rate femtosecond laser pulses at 780 nm is presented using two-photon induced fluorescence technique. A correspondence in the measured two-photon and single-photon cross-section values is seen when the pH changes from acidic to basic conditions (pH = 2-10) for solutions in 1:1 water-ethanol binary mixture. By plotting changes in the single-photon and two-photon fluorescence in this pH range, the excited state pKa values are found...
November 15, 2016: Journal of Fluorescence
https://www.readbyqxmd.com/read/27843919/rosacea-management
#16
REVIEW
Manal Abokwidir, Steven R Feldman
BACKGROUND: Rosacea is a chronic inflammatory skin condition associated with four distinct subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular. PURPOSE: To review the different kinds of management for all subtypes. METHODS: We divided rosacea management into three main categories: patient education, skin care, and pharmacological/procedural interventions. RESULTS: Flushing is better prevented rather than treated, by avoiding specific triggers, decreasing transepidermal water loss by moisturizers, and blocking ultraviolet light...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27842856/hyaluronan-polymeric-micelles-for-topical-drug-delivery
#17
Daniela Šmejkalová, Tomáš Muthný, Kristina Nešporová, Martina Hermannová, Eva Achbergerová, Gloria Huerta-Angeles, Marek Svoboda, Martin Čepa, Veronika Machalová, Dominika Luptáková, Vladimír Velebný
Nanosized materials offer promising strategy for topical drug delivery due to their enhancing effect on drug percutaneous transport across the stratum corneum barrier. In this work, polymeric micelles made from hydrophobized hyaluronic acid (HA) were probed for skin delivery. Compared to non-polymeric micelle solutions containing similar drug amount, in vitro skin penetration analysis indicated 3 times larger deposition of drug in the epidermis and 6 times larger drug deposition in the dermis after 5h of topical treatment in Franz diffusion cells...
January 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27828985/the-diatom-staurosirella-pinnata-for-photoactive-material-production
#18
Roberta De Angelis, Sonia Melino, Paolo Prosposito, Mauro Casalboni, Francesca Romana Lamastra, Francesca Nanni, Laura Bruno, Roberta Congestri
A native isolate of the colonial benthic diatom Staurosirella pinnata was cultivated for biosilica production. The silicified cell walls (frustules) were used as a source of homogeneous and structurally predictable porous biosilica for dye trapping and random laser applications. This was coupled with the extraction of lipids from biomass showing potential to fabricate photoactive composite materials sustainably. The strain was selected for its ease of growth in culture and harvesting. Biosilica and lipids were obtained at the end of growth in indoor photobioreactors...
2016: PloS One
https://www.readbyqxmd.com/read/27828287/random-lasing-from-cholesteric-liquid-crystal-microspheres-dispersed-in-glycerol
#19
Yong Li, Dan Luo, Rui Chen
We demonstrate random lasing from a scattering system formed by a cholesteric liquid crystal dispersed in glycerol. Strong scattering of light is produced from the interference between the cholesteric liquid crystal microsphere and glycerol and leads to random lasing. The optical properties of random lasing, such as intensity, threshold, and the temperature effect on lasing emission are demonstrated. The random laser is distinguished from the band-edge laser generated within the cholesteric liquid crystal microspheres by analyzing the positions of the photonic band-edge of the cholesteric liquid crystal and the photoluminescence of the doped laser dye...
November 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27825211/vibrationally-resolved-lifetimes-of-the-2-1-%C3%AE-u-state-of-na2
#20
Roy B Anunciado, Seth Ashman, Lutz Hüwel
Lifetimes of partially resolved ro-vibrational levels of the Na2 2(1)Σu(+) double well state have been measured for the first time. Ground state sodium dimer molecules in a molecular beam are resonantly excited by the doubled output of a 10 ns pulsed dye laser in the range 333-357 nm. After being allowed to decay for a predetermined time interval, the surviving excited molecules are ionized by 532 nm photons from a delayed Nd:YAG laser and detected in a linear time-of-flight mass spectrometer. By appropriate tuning of the excitation laser and systematic variation of the probe laser delay, lifetimes are obtained for vibrational levels in the range from 22 to 57...
November 7, 2016: Journal of Chemical Physics
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