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Dye laser

Richard Lord, Nicholas E Burr, Noor Mohammed, Venkataraman Subramanian
AIM: To perform a systematic review and meta-analysis for the diagnostic accuracy of in vivo lesion characterization in colonic inflammatory bowel disease (IBD), using optical imaging techniques, including virtual chromoendoscopy (VCE), dye-based chromoendoscopy (DBC), magnification endoscopy and confocal laser endomicroscopy (CLE). METHODS: We searched Medline, Embase and the Cochrane library. We performed a bivariate meta-analysis to calculate the pooled estimate sensitivities, specificities, positive and negative likelihood ratios (+LHR, -LHR), diagnostic odds ratios (DOR), and area under the SROC curve (AUSROC) for each technology group...
March 14, 2018: World Journal of Gastroenterology: WJG
Konstantinos Daskalakis, Aaro Ilmari Väkeväinen, Jani-Petri Martikainen, Tommi K Hakala, Päivi Törmä
Nanoscale coherent light sources offer potentially ultrafast modulation speeds which could be utilized for novel sensors and optical switches. Plasmonic periodic structures combined with organic gain materials have emerged as promising candidates for such nanolasers. Their plasmonic component provides high intensity and ultrafast nanoscale-confined electric fields, while organic gain materials offer fabrication flexibility and low acquisition cost. Despite reports on lasing in plasmonic arrays, lasing dynamics in these structures has not been experimentally studied yet...
March 20, 2018: Nano Letters
Jaidip Jagtap, Gayatri Sharma, Abdul K Parchur, Venkateswara Gogineni, Carmen Bergom, Sarah White, Michael J Flister, Amit Joshi
Vascular supply is a critical component of the tumor microenvironment (TME) and is essential for tumor growth and metastasis, yet the endogenous genetic modifiers that impact vascular function in the TME are largely unknown. To identify the host TME modifiers of tumor vascular function, we combined a novel genetic mapping strategy [Consomic Xenograft Model] with near-infrared (NIR) fluorescence imaging and multiparametric analysis of pharmacokinetic modeling. To detect vascular flow, an intensified cooled camera based dynamic NIR imaging system with 785 nm laser diode based excitation was used to image the whole-body fluorescence emission of intravenously injected indocyanine green dye...
February 1, 2018: Biomedical Optics Express
Hao Chen, Renzhi Hu, Pinhua Xie, Xingbiao Xing, Liuyi Ling, Zhiyan Li, Fengyang Wang, Yihui Wang, Jianguo Liu, Wenqing Liu
An OH radical measurement instrument based on Fluorescence Assay by Gas Expansion (FAGE) has been developed in our laboratory. Ambient air is introduced into a low-pressure fluorescence cell through a pinhole aperture and irradiated by a dye laser at a high repetition rate of 8.5kHz. The OH radical is both excited and detected at 308nm using A-X(0,0) band. To satisfy the high efficiency needs of fluorescence collection and detection, a 4-lens optical system and a self-designed gated photomultiplier (PMT) is used, and gating is actualized by switching the voltage applied on the PMT dynodes...
March 2018: Journal of Environmental Sciences (China)
Naoaki Rikihisa, Mai Tominaga, Shoji Watanabe, Nobuyuki Mitsukawa, Yoshiaki Saito, Hiromi Sakai
Our previous study proposed using artificial blood cells (hemoglobin vesicles, Hb-Vs) as photosensitizers in dye laser treatment for port-wine stains (PWSs). Dye laser photons are absorbed by red blood cells (RBCs) and hemoglobin (Hb) mixture, which potentially produce more heat and photocoagulation and effectively destroy endothelial cells. Hb-Vs combination therapy will improve clinical outcomes of dye laser treatment for PWSs because very small vessels do not contain sufficient RBCs and they are poor absorbers/heaters of lasers...
March 15, 2018: Lasers in Medical Science
Lei Wan, Hengky Chandrahalim, Jian Zhou, Zhaohui Li, Cong Chen, Sangha Cho, Hui Zhang, Ting Mei, Huiping Tian, Yuji Oki, Naoya Nishimura, Xudong Fan, L Jay Guo
We developed chip-scale remote refractive index sensors based on Rhodamine 6G (R6G)-doped polymer micro-ring lasers. The chemical, temperature, and mechanical sturdiness of the fused-silica host guaranteed a flexible deployment of dye-doped polymers for refractive index sensing. The introduction of the dye as gain medium demonstrated the feasibility of remote sensing based on the free-space optics measurement setup. Compared to the R6G-doped TZ-001, the lasing behavior of R6G-doped SU-8 polymer micro-ring laser under an aqueous environment had a narrower spectrum linewidth, producing the minimum detectable refractive index change of 4 × 10-4 RIU...
March 5, 2018: Optics Express
Jun Yeong Park, Bok Won Park, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim, Kwang Joong Kim
BACKGROUND: Diphenylcyclopropenone (DPCP) immunotherapy for viral warts has been used for many years, but no studies have analyzed the treatment effects of DPCP alone, without the use of conventional therapy before immunotherapy. OBJECTIVES: We evaluated clinical efficacy of DPCP monotherapy compared to cryotherapy and pulsed dye laser (PDL) therapy. We also assessed the impact of initial sensitization on clinical response. METHODS: We retrospectively analyzed the medical records of 250 patients with multiple viral warts between January 2008 and December 2015...
March 1, 2018: Journal of Cutaneous Medicine and Surgery
Yalan Rui, Bo Pang, Jinnan Zhang, Yuxi Liu, Huixin Hu, Zicun Liu, Sarah Ama Baidoo, Chang Liu, Yu Zhao, Siwen Li
A polyelectrolyte microcapsule-based layer-by-layer (LbL) technique has been widely used as a multifunctional vehicle for combined tumor therapy. Meanwhile, with the rapid development of combined tumour therapy, the challenge for designing multifunctional drug delivery system has attracted much more attention. Herein, we developed a new type of microcapsule (MC) system called MPA@siRNA@DOX@MC, which conjugated with siRNA and DOX as well as ICG-Der-02 (MPA) by electrostatic absorption. MPA as indocyanine green (ICG) fluorescence dye, exhibiting high fluorescence emission and photothermal conversion ability under NIR laser irradiation, was uploaded onto this drug system for realizing the controllable drug release and cancer theranostics...
March 11, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Ali Bavali, Parviz Parvin, Mohammad Tavassoli, Mohammad Reza Mohebbifar
Angular dependence of the intensity and the emissive wavelength of the laser-induced fluorescence emission in hybrid media (fluorophores+nanoparticles) are investigated using various TiO2 densities as guest nanoscatterers in the ethanolic solutions of the host Rd6G and coumarin 4 (C4) molecules. It is shown that the intensity of the scattered photons varies in terms of the detection angle. When the nanoscatterer density increases at a certain excitation energy, the angular anisotropy enhances. While the emissive wavelength exhibits the spectral shift in terms of the angular variation for Rd6G fluorophores, it remains invariant for C4-based suspension...
March 1, 2018: Applied Optics
Gia Petriashvili, Mauro Daniel Luigi Bruno, Maria Penelope De Santo, Riccardo Barberi
In the last decade, much interest has grown around the possibility to use liquid-crystal droplets as optical microcavities and lasers. In particular, 3D laser emission from dye-doped cholesteric liquid crystals confined inside microdroplets paves the way for many applications in the field of sensors or tunable photonics. Several techniques can be used to obtain small microresonators as, for example, dispersing a liquid crystal inside an immiscible isotropic fluid to create an emulsion. Recently, the possibility to obtain a thin free-standing film starting from an emulsion having a mixture of water and polyvinyl alcohol as isotropic matrix has been reported...
2018: Beilstein Journal of Nanotechnology
Katherine M McKinnon
Flow cytometry is a technology that provides rapid multi-parametric analysis of single cells in solution. Flow cytometers utilize lasers as light sources to produce both scattered and fluorescent light signals that are read by detectors such as photodiodes or photomultiplier tubes. These light signals are converted into electronic signals that are analyzed by a computer and written to a standardized format (.fcs) data file. Cell populations can be analyzed and/or purified based on their fluorescent or light scattering characteristics...
February 21, 2018: Current Protocols in Immunology
E D Feijo, R M Limongi, S Matayoshi
BACKGROUND: Dacryocystorhinostomy (DCR) is the gold standard surgical treatment for nasolacrimal duct obstruction. External DCR is the traditional approach (EXT-DCR); however, the advent of minimally invasive surgeries and the development of optic fiber and laser technologies have made it possible to perform laser transcanalicular DCR (T-DCR), a minimally invasive procedure. This study measured the fluorescein transit time (FTT) after EXT-DCR or T-DCR to evaluate the lacrimal drainage and lacrimal pump function after these two types of DCR...
March 6, 2018: Rhinology
Xian-Wu Hua, Yan-Wen Bao, Fu-Gen Wu
Nucleolus tracking and nucleus-targeted photodynamic therapy are attracting increasing attention due to the importance of nucleolus and the sensitivity of nucleus to various therapeutic stimuli. Herein, a new class of multifunctional fluorescent carbon quantum dots (or carbon dots, CDs) synthesized via the one-pot hydrothermal reaction of m-phenylenediamine and L-cysteine, was reported to effectively target nucleolus. The as-prepared CDs possess superior properties such as low-cost and facile synthesis, good water dispersibility, various surface groups for further modifications, prominent photostability, excellent compatibility, and rapid/convenient/wash-free staining procedures...
March 6, 2018: ACS Applied Materials & Interfaces
Chun-Yen Lin, Ming-Jium Shieh
Recently, nanoparticles (NPs) have been widely investigated for delivery of anticancer drugs. Here, a dual control drug-release modality was developed that uses naturally occurring protein apoferritin loaded with doxorubicin (DOX) and ADS-780 near infrared (NIR) fluorescent dye-decorated NPs (ADNIR NPs). ADNIR NPs act as a grenade to detonate the targeted tumor site following laser irradiation (photothermal therapy, PTT) and explode into cluster warheads (apoferritin-loaded DOX nanocages, AF-DOX NCs) that further destroy the tumor cells (chemotherapy)...
March 5, 2018: Bioconjugate Chemistry
Yoshio Naya, Natsuki Takaha, Takako Okubo, Koji Shiota, Issei Hayashi, Masaru Mori, Seiki Date, Tsuneharu Miki, Osamu Ukimura
Background: Cystoscopy using white light is a standard procedure for diagnosing bladder cancer; however, white light can result in missed lesions that are present, but not visible, such as in cases of carcinoma in situ (CIS). In this case report, we describe observing the nuclei of urothelial carcinoma cells in situ that were not visible with cystoscopy under white light using probe-based confocal laser endomicroscopy (pCLE) with acrinol and fluorescein during transurethral resection of a bladder tumor (TURBT)...
2018: Journal of Endourology Case Reports
H Matsuura, Y Nagasaka
We describe an instrument for the measurement of the Soret and thermodiffusion coefficients in ternary systems based on the transient holographic grating technique, which is called Soret forced Rayleigh scattering (SFRS) or thermal diffusion forced Rayleigh scattering (TDFRS). We integrated the SFRS technique and the two-wavelength detection technique, which enabled us to obtain two different signals to determine the two independent Soret coefficients and thermodiffusion coefficients in ternary systems. The instrument has been designed to read the mass transport simultaneously by two-wavelength lasers with wavelengths of λ = 403 nm and λ = 639 nm...
February 2018: Review of Scientific Instruments
Denis E Bragin, Gloria L Statom, Edwin M Nemoto
OBJECTIVE: In previous work we showed that high intracranial pressure (ICP) in the rat brain induces a transition from capillary (CAP) to pathological microvascular shunt (MVS) flow, resulting in brain hypoxia, edema, and blood-brain barrier (BBB) damage. This transition was correlated with a loss of cerebral blood flow (CBF) autoregulation undetected by static autoregulatory curves but identified by induced dynamic ICP (iPRx) and cerebrovascular (iCVRx) reactivity. We hypothesized that loss of CBF autoregulation as correlated with MVS flow would be identified by iPRx and iCVRx in traumatic brain injury (TBI) with elevated ICP...
2018: Acta Neurochirurgica. Supplement
Rongchao Pan, Ulrich Retzer, Thomas Werblinski, Mikhail N Slipchenko, Terrence R Meyer, Lars Zigan, Stefan Will
Typical commercial pulsed dye laser systems used in the generation of narrowband, tunable ultraviolet radiation for planar laser-induced fluorescence (PLIF) imaging are optimized for either high (∼5-10  kHz) repetition rates at comparatively low ultraviolet pulse energies (hundreds of microjoules) or high-output pulse energies (>10  mJ) at comparatively low repetition rates (∼10  Hz). In this work we use a frequency-doubled Nd:YAG burst-mode laser to pump a custom dye laser system for high pulse energies and repetition rates of 7...
March 1, 2018: Optics Letters
Stephen D Hammack, Campbell D Carter, Aaron W Skiba, Christopher A Fugger, Josef J Felver, Joseph D Miller, James R Gord, Tonghun Lee
Planar laser-induced fluorescence (PLIF) of hydroxyl (OH) and formaldehyde (CH2 O) radicals was performed alongside stereo particle image velocimetry (PIV) at a 20 kHz repetition rate in a highly turbulent Bunsen flame. A dual-pulse burst-mode laser generated envelopes of 532 nm pulse pairs for PIV as well as a pair of 355 nm pulses, the first of which was used for CH2 O PLIF. A diode-pumped solid-state Nd:YAG/dye laser system produced the excitation beam for the OH PLIF. The combined diagnostics produced simultaneous, temporally resolved two-dimensional fields of OH and CH2 O and two-dimensional, three-component velocity fields, facilitating the observation of the interaction of fluid dynamics with flame fronts and preheat layers...
March 1, 2018: Optics Letters
Emel Uzunoglu-Özyürek, Hakan Karaaslan, Sevinç Aktemur Türker, Bahar Özçelik
Objectives: To determine the effect of size and insertion depth of irrigation needle on the amount of apical extruded debris and the amount of penetration depth of sealer using a confocal laser scanning microscope (CLSM). Materials and Methods: Twenty maxillary premolars were assigned to 2 groups ( n = 10), according to the size of needle tip, 28 G or 30 G. Buccal roots of samples were irrigated with respective needle type inserted 1 mm short of the working length (WL), while palatal roots were irrigated with respective needle type inserted 3 mm short of the WL...
February 2018: Restorative Dentistry & Endodontics
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