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https://www.readbyqxmd.com/read/28098320/versatile-tissue-lasers-based-on-high-q-fabry-p%C3%A3-rot-microcavities
#1
Yu-Cheng Chen, Qiushu Chen, Tingting Zhang, Wenjie Wang, Xudong Fan
Biolasers are an emerging technology for next generation biochemical detection and clinical applications. Progress has recently been made to achieve lasing from biomolecules and single living cells. Tissues, which consist of cells embedded in an extracellular matrix, mimic more closely the actual complex biological environment in a living body and therefore are of more practical significance. Here, we developed a highly versatile tissue laser platform, in which tissues stained with fluorophores are sandwiched in a high-Q Fabry-Pérot microcavity...
January 18, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28095541/safety-and-efficacy-evaluation-of-pulsed-dye-laser-treatment-co-sub-2-sub-ablative-fractional-resurfacing-and-combined-treatment-for-surgical-scar-clearance
#2
Joel L Cohen, Roy Geronemus
BACKGROUND & OBJECTIVE: Surgical scars are an unwanted sequela following surgical procedures. Several different treatment modalities and approaches are currently being employed to improve the cosmesis of surgical scars with each having varying degrees of success. The objective of this study was to assess the ef cacy and safety pulsed dye laser treatment, CO2 ablative fractional resurfacing, and a combined treatment with these two modalities for the cosmetic improvement of surgical scarring that occurred following the surgical removal of skin cancer from different anatomic areas...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28093326/in-vivo-pharmacokinetic-studies-and-intracellular-delivery-of-methotrexate-by-means-of-glycine-tethered-plga-based-polymeric-micelles
#3
Madhwi, Rajendra Kumar, Pramod Kumar, Bhupinder Singh, Gajanand Sharma, Om Prakash Katare, Kaisar Raza
Methotrexate is a widely used drug for the treatment of various kinds of cancers. However, numerous challenges are associated with MTX like poor aqueous solubility, dose-dependent side effects and poor-bioavailability. With an aim to explore the potential benefits in drug delivery of MTX, it was intended to fabricate glycine-PLGA-based polymeric micelles. Glycine was chemically linked to PLGA and the linkage was confirmed by FT-IR, and NMR-Spectroscopy. The developed polymeric micelles offered substantial loading to MTX with a pH-dependent drug release profile...
January 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28088993/treatment-of-recalcitrant-port-wine-stains-pws-using-a-combined-pulsed-dye-laser-pdl-and-radiofrequency-rf-energy-device
#4
Yoon-Soo Cindy Bae, Hamad Alabdulrazzaq, Jeremy A Brauer, Roy G Geronemus
BACKGROUND: Pulsed dye laser (PDL) is the treatment of choice for port-wine stains (PWS). Some PWS are recalcitrant to this modality. A number of reasons for PDL treatment resistance have been described, including inadequate heat generation. OBJECTIVE: We evaluated PDL combined with radiofrequency (RF) energy into a single device to target larger and deeper blood vessels and overcome PDL resistance. METHOD: This was an open-label, prospective, single-center investigation of a novel device combining RF energy with PDL conducted to treat recalcitrant PWS...
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28088668/near-infrared-light-triggered-drug-delivery-system-for-higher-efficacy-of-combined-chemo-photothermal-treatment
#5
Yi Chen, Haohuan Li, Yueyang Deng, Haifeng Sun, Xue Ke, Tianyuan Ci
: The combination of chemotherapy and photothermal therapy is a promising strategy for cancer treatment. In the present study, indocyanine green (ICG), a widely used near-infrared (NIR) dye in photothermal therapy, and chemotherapeutic drug-doxorubicin (DOX) were loaded within the nanoparticles of novel designed arylboronic ester and cholesterol modified hyaluronic acid (PPE-Chol1-HA), denoted as PCH-DI. We take advantage of reactive oxygen species (ROS) production capability of ICG and ROS-sensitivity of arylboronic ester to realize controllable drug release...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28079942/treatment-of-capillary-malformation-using-topical-timolol-combined-with-585-nm-pulsed-dye-laser-a-prospective-randomized-split-lesion-study
#6
Sang-Jin Cheon, Woo-Haing Shim, Gun-Wook Kim, Hoon-Soo Kim, Byung-Soo Kim, Moon-Bum Kim, Hyun-Chang Ko
Capillary malformation (CM) is a congenital vascular malformation characterized by the dilation of superficial dermal blood vessels.(1)  Currently, pulsed dye laser (PDL) is considered the gold standard for the treatment of CM.(1)  However, its use results in incomplete clearance despite multiple sessions and relapses during long-term follow-up.(1)  Alternative methods are needed to achieve improved therapeutic results. This article is protected by copyright. All rights reserved.
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28078885/an-ambipolar-bodipy-derivative-for-a-white-exciplex-oled-and-cholesteric-liquid-crystal-laser-towards-multi-functional-devices
#7
Marian Chapran, Enrico Angioni, Neil John Findlay, Benjamin Breig, Vladyslav Cherpak, Pavlo Stakhira, Tell Tuttle, Dmytro Volyniuk, Juozas Vidas Grazulevicius, Yuriy A Nastishin, Oleg D Lavrentovich, Peter John Skabara
A new interface engineering method is demonstrated for the preparation of an efficient white organic light emitting diode (WOLED) by embedding an ultra-thin layer of the novel ambipolar red emissive compound 4,4-di-fluoro-2,6-di(4-hexylthiopen-2-yl)-1,3,5,7,8-pentamethyl-4-bora-3a,4a-diaza-s-indacene (bThBODIPY) in the exciplex formation region. The compound shows a hole and electron mobility of 3.3 × 10-4 cm2 V-1 s-1 and 2 × 10-4 cm2 V-1 s-1, respectively at electric fields higher than 5.3 × 105 V cm-1...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28078631/investigation-of-solvent-effects-on-photophysical-properties-of-new-aminophthalimide-derivatives-based-on-methanesulfonate
#8
Ayse Tan, Ebru Bozkurt, Yunus Kara
Novel aminophthalimide derivatives were synthesized starting from (3aR,7aS)-2-(2-hydroxypropyl)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione (9) , and solvent effects on the photo-physical properties of these newly synthesized aminophthalimide derivatives (compounds 14 and 15) were investigated using UV-Vis absorption spectroscopy, steady-state and time-resolved fluorescence measurements. Both absorption and fluorescence spectra exhibited bathochromic shift with the increased polarity of the solvents for both molecules...
January 11, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28078608/study-on-the-polarization-of-random-lasers-from-dye-doped-nematic-liquid-crystals
#9
Lihua Ye, Chong Zhao, Yangyang Feng, Bing Gu, Yiping Cui, Yanqing Lu
Random lasers from dye-doped nematic liquid crystal (DDNLC) cells with different rubbing methods were observed due to different random ring cavities that were formed. Through constructing cells with different rubbing methods on the forward and backward surfaces of light-emitting sides, we can get two random laser beams with different polarization directions from one DDNLC cell at the same time, and the polarization direction is along the rubbing direction of the light-emitting sides. Additionally, the influence of external electric field on the polarization degree of random lasers was also studied...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28078504/pulsed-dye-laser-on-ecchymoses-clinical-and-histological-assessment
#10
Adrián Alegre-Sánchez, D Saceda-Corralo, G Segurado-Miravalles, D de Perosanz-Lobo, P Fonda-Pascual, O M Moreno-Arrones, D Buendía-Castaño, B Perez-García, P Boixeda
No abstract text is available yet for this article.
January 11, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28076462/effect-of-ultrasonic-streaming-on-intra-dentinal-disinfection-and-penetration-of-calcium-hydroxide-paste-in-endodontic-treatment
#11
Marcela Paola Castro Arias, Amanda Garcia Alves Maliza, Raquel Zanin Midena, Márcia Sirlene Zardin Graeff, Marco Antonio Húngaro Duarte, Flaviana Bombarda de Andrade
Objective: The antimicrobial effect of ultrasonic agitation of calcium hydroxide (CH) pastes in infected bovine dentin and their penetrability were evaluated using confocal laser scanning microscopy (CLSM) and microbiological culture. Material and Methods: Fifty-two bovine teeth were infected with Enterococcus faecalis using a new contamination protocol; then they received CH paste and were divided into groups with or without ultrasound. Ultrasonic agitation was conducted for 1 min with a plain point insert...
November 2016: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28074643/ultra-photostable-mesoporous-silica-coated-gap-enhanced-raman-tags-gerts-for-high-speed-bioimaging
#12
Yuqing Zhang, Yuanyuan Qiu, Li Lin, Hongchen Gu, Zeyu Xiao, Jian Ye
Surface enhanced Raman scattering (SERS) tags can be utilized as optical labeling nanoprobes similar to fluorescent dyes and quantum dots for bioimaging with additional advantages of the fingerprint vibrational signal as a unique optical code and the ultra-narrow linewidth for multiplexing. However, the development of SERS imaging technique is much less well-established compared to fluorescence imaging mainly due to the speed limitation. An effective strategy to improve the SERS imaging speed and simultaneously maintain the photostability of SERS tags has been never reported to the best of our knowledge...
January 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28068444/effectiveness-of-an-eyelid-thermal-pulsation-procedure-to-treat-recalcitrant-dry-eye-symptoms-after-laser-vision-correction
#13
Craig S Schallhorn, Julie M Schallhorn, Stephen Hannan, Steven C Schallhorn
PURPOSE: To provide an initial retrospective evaluation of the effectiveness of a thermal pulsation system to treat intractable patient-reported dye eye symptoms following laser vision correction. METHODS: A total of 109 eyes of 57 patients underwent thermal pulsation therapy (LipiFlow; TearScience, Morrisville, NC) for the treatment of dry eye symptoms following laser vision correction. A standardized dry eye questionnaire, the Standard Patient Evaluation of Eye Dryness (SPEED II), was administered to all patients before and after thermal pulsation therapy...
January 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28068207/the-effect-of-diode-laser-on-planktonic-enterococcus-faecalis-in-infected-root-canals-in-an-ex-vivo-model
#14
Gilda Cretella, Carlo Lajolo, Raffaella Castagnola, Francesco Somma, MariaTeresa Inchingolo, Luca Marigo
OBJECTIVE: This study examined the bactericidal effect of diode laser irradiation against intracanal Enterococcus faecalis. METHODS AND MATERIALS: m total of 128 extracted single-rooted and single-canal teeth were treated with ProTaper instruments (Dentsply Maillefer, Ballaigues, Switzerland). A total of 120 root canals were inoculated with E. faecalis for 21 days, and the samples were randomly divided into five groups: Group 1 (n = 24) samples were irrigated with only saline solution (positive controls); Group 2 (n = 24) was treated with only 5...
January 9, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28059273/flexible-and-achromatic-generation-of-optical-vortices-by-use-of-vector-beam-recorded-functionalized-liquid-crystals
#15
Moritsugu Sakamoto, Tomoyuki Sasaki, Tran Mien Tien, Kohei Noda, Nobuhiro Kawatsuki, Hiroshi Ono
In this study, we investigated the spatial light modulation properties of an optical vortex (OV) generator consisting of azo-dye-doped polymer liquid crystal (ADDLC) and a vector beam illuminator, focusing on flexibility and achromaticity for generating OVs. Uniaxially aligned ADDLC forms three-dimensional photoinduced twisted anisotropic structures under vector beam illumination, and can generate high-order OVs with even-numbered topological charges that correspond to the polarization pattern of the illuminating vector beam...
December 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/28059252/temporal-resolution-beyond-the-average-pulse-duration-in-shaped-noisy-pulse-transient-absorption-spectroscopy
#16
Kristina Meyer, Niklas Müller, Zuoye Liu, Thomas Pfeifer
In time-resolved spectroscopy, it is a widespread belief that the temporal resolution is determined by the laser pulse duration. Recently, it was observed and shown that partially coherent laser pulses as they are provided by free-electron-laser (FEL) sources offer an alternative route to reach a temporal resolution below the average pulse duration. Here, we demonstrate the generation of partially coherent light in the laboratory like we observe it at FELs. We present the successful implementation of such statistically fluctuating pulses by using the pulse-shaping technique...
December 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/28058421/excited-state-proton-transfer-in-2-hydroxychalcone-derivatives
#17
Michael Dommett, Rachel Crespo-Otero
Fluorophores exhibiting excited-state intramolecular proton transfer (ESIPT) are promising candidates for applications ranging from imaging and probing to laser dyes, optoelectronic devices and molecular logic gates. Recently, ESIPT-active solid-state emitters based on 2'-hydroxychalcone have been synthesized. The compounds are almost non-emissive in solution but emit in the deep red/NIR region when crystalline. Herein, we present a comprehensive theoretical investigation of the gas-phase excited state relaxation pathways in five 2'-hydroxychalcone systems, using a combination of static and non-adiabatic simulations...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28056485/evidence-of-invasive-and-non-invasive-treatment-modalities-for-hypertrophic-scars-a-systematic-review
#18
Mona Kafka, Vanessa Collins, Lars-Peter Kamolz, Thomas Rappl, Ludwik K Branski, Paul Wurzer
Currently, there are various therapeutic approaches to reduce hypertrophic scarring, however, there is no standard evidence-based treatment protocol. Hence, we performed a systematic review to obtain a summary of the latest clinical trials to evaluate evidence for the treatment of hypertrophic scars. The review protocol was registered and approved by PROSPERO (CRD42015027040). PubMed and Web of Science were searched using predefined MeSH-Terms to identify studies published within the last 10 years regarding treatment for hypertrophic scars...
January 5, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28053232/directional-emission-from-dye-functionalized-plasmonic-dna-superlattice-microcavities
#19
Daniel J Park, Jessie C Ku, Lin Sun, Clotilde M Lethiec, Nathaniel P Stern, George C Schatz, Chad A Mirkin
Three-dimensional plasmonic superlattice microcavities, made from programmable atom equivalents comprising gold nanoparticles functionalized with DNA, are used as a testbed to study directional light emission. DNA-guided nanoparticle colloidal crystallization allows for the formation of micrometer-scale single-crystal body-centered cubic gold nanoparticle superlattices, with dye molecules coupled to the DNA strands that link the particles together, in the form of a rhombic dodecahedron. Encapsulation in silica allows one to create robust architectures with the plasmonically active particles and dye molecules fixed in space...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28050834/xylem-characterization-using-improved-pseudo-schiff-propidium-iodide-staining-of-whole-mount-samples-and-confocal-laser-scanning-microscopy
#20
Mario Coiro, Elisabeth Truernit
An improved pseudo-Schiff propidium iodide staining technique well suited for, but not limited to, the visualization of xylem cell walls in whole mount samples is presented. The pseudo-Schiff reaction results in covalent binding of the fluorescent dye propidium iodide to cell walls. This stable linkage permits the use of clearing agents after staining, which is itself improved following pretreatment of the plant tissue. A subsequent acid alcohol washing step eliminates unbound propidium iodide to reduce background fluorescence...
2017: Methods in Molecular Biology
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