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https://www.readbyqxmd.com/read/29329953/canine-macrophages-can-like-human-macrophages-be-in-vitro-activated-toward-the-m2a-subtype-relevant-in-allergy
#1
Ina Herrmann, Jelena Gotovina, Judit Fazekas-Singer, Michael B Fischer, Karin Hufnagl, Rodolfo Bianchini, Erika Jensen-Jarolim
The M2a subtype of macrophages plays an important role in human immunoglobulin E (IgE-mediated allergies) and other Th2 type immune reactions. In contrast, very little is known about these cells in the dog. Here we describe an in-vitro method to activate canine histiocytic DH82 cells and primary canine monocyte-derived macrophages (MDMs) toward the M2a macrophages using human cytokines. For a side-by-side comparison, we compared the canine cells to human MDMs, and the human monocytic cell line U937 activated towards M1-and M2a cells on the cellular and molecular level...
January 9, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29317509/human-placental-syncytiotrophoblasts-restrict-toxoplasma-gondii-attachment-and-replication-and-respond-to-infection-by-producing-immunomodulatory-chemokines
#2
Stephanie E Ander, Elizabeth N Rudzki, Nitin Arora, Yoel Sadovsky, Carolyn B Coyne, Jon P Boyle
Toxoplasma gondii is a major source of congenital disease worldwide, but the cellular and molecular factors associated with its vertical transmission are largely unknown. In humans, the placenta forms the key interface between the maternal and fetal compartments and forms the primary barrier that restricts the hematogenous spread of microorganisms. Here, we utilized primary human trophoblast (PHT) cells isolated from full-term placentas and human midgestation chorionic villous explants to determine the mechanisms by which human trophoblasts restrict and respond to T...
January 9, 2018: MBio
https://www.readbyqxmd.com/read/29289711/lipopolysaccharide-induces-tumor-necrosis-factor-receptor-1-independent-relocation-of-lymphocytes-from-the-red-pulp-of-the-mouse-spleen
#3
Ivana M Lalić, Rudolf Bichele, Anja Repar, Sanja Z Despotović, Saša Petričević, Martti Laan, Pärt Peterson, Jürgen Westermann, Živana Milićević, Ivana Mirkov, Novica M Milićević
It is well known that bacterial lipopolysaccharide (LPS) induces migration of several cellular populations within the spleen. However, there are no data about the impact of LPS on B and T lymphocytes present in the red pulp. Therefore, we used an experimental model in which we tested the effects of intravenously injected LPS on the molecular, cellular and structural changes of the spleen, with special reference to the red pulp lymphocytes. We discovered that LPS induced a massive relocation of B and T lymphocytes from the splenic red pulp, which was independent of the tumor necrosis factor receptor-1 signaling axis...
December 28, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29279059/systemic-inflammation-mediates-the-detrimental-effects-of-obesity-on-asthma-control
#4
Xin Zhang, Jing Zheng, Li Zhang, Ying Liu, Gai Ping Chen, Hong Ping Zhang, Lei Wang, De Ying Kang, Lisa G Wood, Gang Wang
BACKGROUND: Obesity negatively impacts asthma control, but the inflammatory mechanisms are poorly understood. OBJECTIVE: To explore which systemic inflammatory mediators mediate the effects of obesity on asthma control. METHODS: The subjects with stable asthma (n = 108) underwent assessment of clinical characteristics, which included using The Asthma Control Questionnaire (ACQ)-6. Obesity was defined as a body mass index (BMI) of ≥30 kg/m2, overweight was defined as BMI between 25 to 29...
January 2, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29245934/apolipoprotein-a-i-mimetic-peptide-4f-suppresses-tumor-associated-macrophages-and-pancreatic-cancer-progression
#5
Meiyu Peng, Qi Zhang, Yingnan Cheng, Shuyu Fu, Huipeng Yang, Xiangdong Guo, Jieyou Zhang, Lina Wang, Lijuan Zhang, Zhenyi Xue, Yan Li, Yurong Da, Zhi Yao, Liang Qiao, Rongxin Zhang
Pancreatic cancer is an aggressive malignancy that is unresponsive to conventional radiation and chemotherapy. Therefore, development of novel immune therapeutic strategies is urgently needed. L-4F, an Apolipoprotein A-I (ApoA-I) mimetic peptide, is engineered to mimic the anti-inflammatory and anti-oxidative functionalities of ApoA-I. In this work, H7 cells were orthotopically implanted in C57BL/6 mice and treated with L-4F. Then, pancreatic cancer progression and the inflammatory microenvironment were investigated in vivo...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207093/potential-inhibitory-effects-of-the-traditional-herbal-prescription-hyangso-san-against-skin-inflammation-via-inhibition-of-chemokine-production-and-inactivation-of-stat1-in-hacat-keratinocytes
#6
Hye-Sun Lim, Sae-Rom Yo, Mee-Young Lee, Chang-Seob Seo, Hyeun-Kyoo Shin, Soo-Jin Jeong
Inflammatory skin disease are caused by multiple factors, including susceptibility genes, and immunologic and environmental factors, and are characterized by an increase in epidermal thickness and the infiltration of macrophages, keratinocytes, mast cells, eosinophils and other inflammatory cells. Keratinocytes may serve an important role in the pathogenesis of inflammatory skin diseases. The traditional herbal decoction Hyangso‑san (HSS) has been used to treat symptoms of the common cold, including headache, pantalgia, fever and chills...
November 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29156846/s100a14-rs11548103-g-a-polymorphism-is-associated-with-a-decreased-risk-of-esophageal-cancer-in-a-chinese-population
#7
Yang Zhao, Feng Yao, Weifeng Tang, Haiyong Gu, Heng Zhao
Objective: In China in 2009, esophageal cancer was the fifth most commonly diagnosed malignancy and the fourth leading cause of malignancy-related death. Accumulating evidence indicates that genetic factors might play an important role in esophageal squamous cell carcinoma (ESCC) carcinogenesis. Materials and Methods: In total, we recruited 629 ESCC patients and 686 controls. Genetic variations in the S100A14, MLH1, SMAD7 and CCL22/MDC genes were measured using the ligation detection reaction method...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29122683/high-cxcl10-ip-10-levels-are-a-hallmark-in-the-clinical-evolution-of-the-hiv-infection
#8
Jacqueline María Valverde-Villegas, Rúbia Marília de Medeiros, Joel Henrique Ellwanger, Breno Riegel Santos, Marineide Gonçalves de Melo, Sabrina Esteves de Matos Almeida, José Artur Bogo Chies
The aim of this study was to investigate the modulation of plasma CXCL10, CCL20, CCL22, CCL2, CCL17 and CCL24 levels in HIV-positive patients grouped according to extreme phenotypes of progression to AIDS, and at different stages of HIV infection. HIV-positive individuals with extreme phenotypes of AIDS progression (n=58) at different clinical stages (chronic individuals, both pre-HAART and under-HAART) and HIV-negative controls (n=20) were evaluated. Additionally, HIV-positive individuals that initiated HAART with >350CD4(+)T-cells/mm(3) were compared with those who initiated treatment with <350CD4(+)T-cells/mm(3)...
November 6, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29118379/a-new-antagonist-for-ccr4-attenuates-allergic-lung-inflammation-in-a-mouse-model-of-asthma
#9
Yang Zhang, Yinfang Wu, Hui Qi, Hongwei Gong, Yan Zhang, Enquan Xu, Song Li, Dalong Ma, Junhai Xiao, Ying Wang, Wen Li, Huahao Shen
CCR4 is highly expressed on Th2 cells. CCR4 ligands include CCL22 and CCL17. Chemokine-like factor 1 can also mediate chemotaxis via CCR4. We designed and synthetized novel CCR4 antagonists, which were piperazinyl pyridine derivatives, for disrupting the interaction between three ligands and CCR4. We also determined whether these novel CCR4 antagonists could alleviate allergic asthma in a mouse. For identifying the potent compounds in vitro, we used chemotaxis inhibition and competition binding assays induced by CCL22, CCL17 and one of CKLF1's C-terminal peptides, C27...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116124/monocytes-from-patients-with-primary-ciliary-dyskinesia-show-enhanced-inflammatory-properties-and-produce-higher-levels-of-pro-inflammatory-cytokines
#10
M Cockx, M Gouwy, P Ruytinx, I Lodewijckx, A Van Hout, S Knoops, N Pörtner, I Ronsse, L Vanbrabant, V Godding, K De Boeck, J Van Damme, M Boon, S Struyf
Patients with Primary Ciliary Dyskinesia (PCD) suffer from recurrent upper and lower airway infections due to defects in the cilia present on the respiratory epithelium. Since chronic inflammatory conditions can cause changes in innate immune responses, we investigated whether monocytes isolated from the peripheral blood of pediatric PCD patients respond differently to inflammatory stimuli, compared to monocytes from healthy children and adults. The receptor for C5a (C5aR) was upregulated in PCD, whereas expression levels of the leukocyte chemoattractant receptors CCR1, CCR2, CCR5, BLT1 and FPR1 on PCD monocytes were similar to those on monocytes from healthy individuals...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29107385/ccl2-conditionally-determines-ccl22-dependent-th2-accumulation-during-tgf-%C3%AE-induced-breast-cancer-progression
#11
Palash Kumar Mandal, Subir Biswas, Gunjan Mandal, Suman Purohit, Arnab Gupta, Amita Majumdar Giri, Sougata Roy Chowdhury, Arindam Bhattacharyya
We investigated expressions of -CC chemokine ligand 2 (CCL2) and CCL5 in tumor samples from 147 breast cancer (BCa) patients and correlated with transforming growth factor-β (TGF-β) expression. We observed an inverse correlation of TGF-β expression with CCL2, CCL5 expression in early stages of BCa. On contrary, in late stages, CCL2, not CCL5, expression was found to be directly proportional with TGF-β expression. TGF-β stimulated MDA-MB-231 cells to express CCL2, however, downregulated both CCL2 and CCL5 in MCF-7...
October 16, 2017: Immunobiology
https://www.readbyqxmd.com/read/29099057/the-c-c-chemokines-ccl17-and-ccl22-and-their-receptor-ccr4-in-cns-autoimmunity
#12
REVIEW
Stefanie Scheu, Shafaqat Ali, Christina Ruland, Volker Arolt, Judith Alferink
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). It affects more than two million people worldwide, mainly young adults, and may lead to progressive neurological disability. Chemokines and their receptors have been shown to play critical roles in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a murine disease model induced by active immunization with myelin proteins or transfer of encephalitogenic CD4⁺ T cells that recapitulates clinical and neuropathological features of MS...
November 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29069516/conserved-structures-formed-by-heterogeneous-rna-sequences-drive-silencing-of-an-inflammation-responsive-post-transcriptional-operon
#13
Abhijit Basu, Niyati Jain, Blanton S Tolbert, Anton A Komar, Barsanjit Mazumder
RNA-protein interactions with physiological outcomes usually rely on conserved sequences within the RNA element. By contrast, activity of the diverse g amma-interferon- a ctivated i nhibitor of t ranslation (GAIT)-elements relies on the conserved RNA folding motifs rather than the conserved sequence motifs. These elements drive the translational silencing of a group of chemokine (CC/CXC) and chemokine receptor (CCR) mRNAs, thereby helping to resolve physiological inflammation. Despite sequence dissimilarity, these RNA elements adopt common secondary structures (as revealed by 2D- 1 H NMR spectroscopy), providing a basis for their interaction with the RNA-binding GAIT complex...
October 24, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29069507/blockade-of-gm-csf-pathway-induced-sustained-suppression-of-myeloid-and-t-cell-activities-in-rheumatoid-arthritis
#14
Xiang Guo, Brandon W Higgs, Anne-Christine Bay-Jensen, Yuling Wu, Morten A Karsdal, Michael Kuziora, Alex Godwood, David Close, Patricia C Ryan, Lorin K Roskos, Wendy I White
Objectives: Targeting the granulocyte-macrophage colony-stimulating factor (GM-CSF) pathway holds great potential in the treatment of inflammatory diseases. Mavrilimumab, a human monoclonal GM-CSF receptor-α antibody, has demonstrated clinical efficacy in RA. Our current study aimed to elucidate mechanisms of action and identify peripheral biomarkers associated with therapeutic responses of GM-CSF antagonism in RA. Methods: A 24-week placebo (PBO)-controlled trial was conducted in 305 RA patients who received mavrilimumab (30, 100 or 150 mg) or PBO once every 2 weeks...
October 23, 2017: Rheumatology
https://www.readbyqxmd.com/read/29055885/industrial-hog-farming-is-associated-with-altered-circulating-immunological-markers
#15
Jonathan N Hofmann, Meredith S Shiels, Melissa C Friesen, Troy J Kemp, Anil K Chaturvedi, Charles F Lynch, Christine G Parks, Ligia A Pinto, Allan Hildesheim, Michael C R Alavanja, Laura E Beane Freeman
OBJECTIVES: The previously observed inverse association between hog farming and risk of lung cancer in the Agricultural Health Study (AHS) has been attributed to endotoxin exposure, the levels of which are particularly high in industrial hog confinement facilities. We conducted an investigation to explore the potential biological mechanisms underlying this association, as well as other immunological changes associated with hog farming. METHODS: Serum immune marker levels were measured using a multiplexed bead-based assay in 61 active hog farmers and 61 controls matched on age, phlebotomy date and raising cattle...
October 21, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29050978/chrysin-attenuates-atopic-dermatitis-by-suppressing-inflammation-of-keratinocytes
#16
Jin Kyeong Choi, Yong Hyun Jang, Soyoung Lee, Sang-Rae Lee, Young-Ae Choi, Meiling Jin, Jung Ho Choi, Jee Hun Park, Pil-Hoon Park, Hyukjae Choi, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
We previously reported the inhibitory effect of chrysin, a natural flavonoid plentifully contained in propolis, vegetables and fruits, on the mast cell-mediated allergic reaction. In this study, we evaluated the effect of chrysin on atopic dermatitis (AD) and defined underlying mechanisms of action. We used an AD model in BALB/c mice by the repeated local exposure of 2,4-dinitrochlorobenzene (DNCB) and house dust mite (Dermatophagoides farinae extract, DFE) to the ears. Repeated alternative treatment of DNCB/DFE caused AD-like skin lesions...
October 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29050765/alveolar-macrophages-from-tuberculosis-patients-display-an-altered-inflammatory-gene-expression-profile
#17
Lelia Lavalett, Hector Rodriguez, Hector Ortega, Wolfgang Sadee, Larry S Schlesinger, Luis F Barrera
Alveolar macrophages (AMs) are major targets of Mycobacterium tuberculosis (Mtb) infection, critical during the progression of active tuberculosis (TB). The complex immunopathology of TB generates diverse microenvironments in the lung, which shape immune responses by AMs. In the current study, we perform whole genome microarray transcriptional profiling on RNA isolated from AMs from TB patients (AMsTB) compared to AMs from control subjects (AMsCT) using bronchoalveolar lavage (BAL). Our hypothesis was that systemic effects on the local lung microenvironment during TB affect the transcriptional response of AMsTB...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29042607/abnormal-m1-m2-macrophage-phenotype-profiles-in-the-small-airway-wall-and-lumen-in-smokers-and-chronic-obstructive-pulmonary-disease-copd
#18
Mathew Suji Eapen, Philip M Hansbro, Kielan McAlinden, Richard Y Kim, Chris Ward, Tillie-Louise Hackett, Eugene H Walters, Sukhwinder Singh Sohal
We explore potential dysregulation of macrophage phenotypes in COPD pathogenesis through integrated study of human small airway tissue, bronchoalveolar lavage (BAL) and an experimental murine model of COPD. We evaluated human airway tissue and BAL from healthy controls, normal lung function smokers (NLFS), and COPD subjects. Both small airways and BAL cells were immunohistochemically stained with anti-CD68 for total macrophages and with anti-CD163 for M2, and anti-iNOS for M1 macrophages. Multiplex ELISA measured BAL cytokines...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28990098/anti%C3%A2-inflammatory-effect-of-amomum%C3%A2-xanthioides-in-a-mouse-atopic-dermatitis-model
#19
Young-Ae Choi, Jin Kyeong Choi, Yong Hyun Jang, Soyoung Lee, Sang-Rae Lee, Jung Ho Choi, Jee Hun Park, Tae-Yong Shin, Sang-Hyun Kim
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. The present study investigated the effects of Amomum xanthioides extract (AXE) on AD‑like skin inflammation using a Dermatophagoides farinae extract (DFE) and 2,4‑dinitrochlorobenzene (DNCB)‑induced mouse AD model. Hematoxylin and eosin staining results demonstrated that repeated DFE/DNCB exposure markedly increased the thickening of the dermis and epidermis, in addition to the infiltration of eosinophils and mast cells. However, oral administration of AXE reduced these histopathological alterations in a dose‑dependent manner...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28987144/cancer-associated-fibroblasts-cafs-are-activated-in-cutaneous-basal-cell-carcinoma-and-in-the-peritumoural-skin
#20
Silje Haukali Omland, Erika Elgstrand Wettergren, Tobias Mourier, Anders Johannes Hansen, Maria Asplund, Sarah Mollerup, Robert Robert
BACKGROUND: Cutaneous basal cell carcinoma (BCC) is the commonest cancer worldwide. BCC is locally invasive and the surrounding stromal microenvironment is pivotal for tumourigenesis. Cancer associated fibroblasts (CAFs) in the microenvironment are essential for tumour growth in a variety of neoplasms but their role in BCC is poorly understood. METHODS: Material included facial BCC and control skin from the peritumoural area and from the buttocks. With next-generation sequencing (NGS) we compared mRNA expression between BCC and peritumoural skin...
October 7, 2017: BMC Cancer
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