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https://www.readbyqxmd.com/read/29764904/aberrant-mrp14-expression-in-thyroid-follicular-cells-mediates-chemokine-secretion
#1
Xuan Luo, Tingting Zheng, Chaoming Mao, Xin Dong, Xiao Mou, Chengcheng Xu, Qingyan Lu, Baocui Liu, Shengjun Wang, Yichuan Xiao
Myeloid-related protein 14 (MRP14) is responsible for inflammatory reactions. However, the correlation between MRP14 and Hashimoto's thyroiditis (HT) is still not clear. In this study, we examined the status of MRP14 in thyroid tissues and sera of HT patients and explored the mechanism of IL-1β-mediated regulation of MRP14 expression, as well as the effects of MRP14 on pro-inflammatory chemokine secretion in thyroid follicular cells (TFCs), to elucidate the role of MRP14 in HT development. Our results showed dramatically increased MRP14 expression in thyroid tissues and sera from HT patients...
May 15, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29746583/decreased-expression-of-ccl17-in-the-disrupted-nasal-polyp-epithelium-and-its-regulation-by-il-4-and-il-5
#2
Byoungjae Kim, Hyun-Ji Lee, Nu-Ri Im, Doh Young Lee, Ha Kyun Kim, Cha Young Kang, Il-Ho Park, Seung Hoon Lee, Heung-Man Lee, Sang Hag Lee, Seung-Kuk Baek, Tae Hoon Kim
BACKGROUND: In airway epithelium, thymus and activation-regulated chemokine (CCL17) and macrophage-derived chemokine (CCL22) are induced by defective epithelial barriers such as E-cadherin and attract the effector cells of Th2 immunity. However, the association between the epithelial barrier and CCL17 expression has not been studied in chronic rhinosinusitis with nasal polyp (CRSwNP). Thus, we aimed to evaluate the expression of CCL17 and its regulation by Th cytokines in nasal polyp (NP) epithelial cells...
2018: PloS One
https://www.readbyqxmd.com/read/29745990/an-il-10-dominant-polarization-of-monocytes-is-a-feature-of-indian-visceral-leishmaniasis
#3
Susmita Roy, Debanjan Mukhopadhyay, Shibabrata Mukherjee, Srija Moulik, Soumyadip Chatterji, Nayan Brahme, Netai Pramanik, Rama P Goswami, Bibhuti Saha, Mitali Chatterjee
BACKGROUND: Leishmania donovani, the causative parasite of Visceral Leishmaniasis (VL) deviously manipulates host monocytes/macrophages to ensure its survival. Although monocytes/macrophages from patients with VL have demonstrated an impaired oxidative burst and antigen presentation, an unanswered yet pertinent question remains as to whether they are deactivated or alternatively activated. METHODS AND RESULTS: The significantly raised plasma levels of IL-4/IL-13 and IL-10 in VL patients suggested a microenvironment conducive for alternative activation of monocytes/macrophages...
May 10, 2018: Parasite Immunology
https://www.readbyqxmd.com/read/29736291/optimization-of-cytokine-milieu-to-reproduce-atopic-dermatitis-related-gene-expression-in-hacat-keratinocyte-cell-line
#4
Hee Joo Kim, Jinok Baek, Jong Rok Lee, Joo Young Roh, YunJae Jung
Although atopic dermatitis (AD) is characterized by cytokine production predominantly mediated by T helper (Th) 2 cells, AD pathogenesis also involves innate immune and Th1 cells. To optimize the cytokine milieu required for accurate reproduction of AD-related gene expression profile in vitro , we evaluated the expression pattern of CCL22 , CCL17 , IL5 , IL13 , IL33 , IL25 , TSLP , FLG , and LOR in human lesional AD skin and cytokine-stimulated HaCaT cells. An increase in Th2 mediators ( IL5 , IL13 , CCL22 , CCL17, IL25 , IL33 , and TSLP ) and a decrease in genes related to cornified cell envelope (filaggrin and loricrin) were observed in human AD lesions...
April 2018: Immune Network
https://www.readbyqxmd.com/read/29712728/acidic-mammalian-chitinase-negatively-affects-immune-responses-during-acute-and-chronic-aspergillus-fumigatus-exposure
#5
Jaleesa M Garth, Joseph J Mackel, Kristen M Reeder, Jonathan P Blackburn, Chad W Dunaway, Zhihong Yu, Sadis Matalon, Lori Fitz, Chad Steele
Chitin is a polysaccharide that provides structure and rigidity to the cell walls of fungi and insects. Mammals possess multiple chitinases, which function to degrade chitin, thereby supporting a role for chitinases in immune defense. However, chitin degradation has been implicated in the pathogenesis of asthma. Here, we determined the impact of acidic mammalian chitinase (AMCase; Chia ) deficiency on host defense during acute exposure to the fungal pathogen Aspergillus fumigatus as well as its contribution to A...
April 30, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29708439/acteoside-relieves-mesangial-cell-injury-by-regulating-th22-cell-chemotaxis-and-proliferation-in-iga-nephropathy
#6
Lu Gan, Xiaozhao Li, Mengyuan Zhu, Chen Chen, Huimin Luo, Qiaoling Zhou
The existing therapies of IgA nephropathy are unsatisfying. Acteoside, the main component of Rehmannia glutinosa with anti-inflammatory and anti-immune effects, can improve urinary protein excretion and immune disorder. Th22 cell is involved in IgA nephropathy progression. This study was determined to explore the effect of acteoside on mesangial injury underlying Th22 cell disorder in IgA nephropathy. Serum Th22 cells and urine total protein of patients with IgA nephropathy were measured before and after six months treatment of Rehmannia glutinosa acteoside or valsartan...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29669721/ppar-%C3%AE-contributes-to-immunity-by-cancer-vaccines-that-secrete-gm-csf
#7
Girija Goyal, Karrie Wong, Christopher J Nirschl, Nicholas Souders, Donna Neuberg, Niroshana Anandasabapathy, Glenn Dranoff
Peroxisome proliferator activated receptor-γ (PPARγ) is a lipid-activated nuclear receptor that promotes immune tolerance through effects on macrophages, dendritic cells (DCs), and regulatory T cells (Tregs). Granulocyte-macrophage colony stimulating factor (GM-CSF) induces PPARγ expression in multiple myeloid cell types. GM-CSF contributes to both immune tolerance and protection, but the role of PPARγ in these pathways is poorly understood. Here we reveal an unexpected stimulatory role for PPARγ in the generation of antitumor immunity with irradiated, GM-CSF-secreting tumor-cell vaccines (GVAX)...
April 18, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29663331/three-cases-of-advanced-cutaneous-angiosarcoma-treated-with-eribulin-investigation-of-serum-soluble-cd163-and-cxcl10-as-possible-biomarkers-predicting-the-biological-behaviour-of-angiosarcoma
#8
T Fujimura, Y Sato, Y Kambayashi, K Tanita, A Tsukada, H Terui, A Hashimoto, S Aiba
Cutaneous angiosarcoma (CAS) is a highly aggressive vascular tumour that recurs locally and metastasizes early. Although chemoradiotherapy with taxanes shows a high response rate with prolonged survival, second-line therapy for advanced CAS remains contentious. This report describes three cases of advanced CAS treated with eribulin. In addition, we investigated serum sCD163, CXCL10 and CCL22 levels at several time points of tumour progression in these patients, revealing serum levels of sCD163 and CXCL10 as potential biomarkers for progression of CAS...
April 17, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29662241/low-mother-to-child-ccl22-chemokine-levels-are-inversely-related-to-mite-sensitization-and-asthma-in-early-childhood
#9
Chih-Yung Chiu, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Sui-Ling Liao, Shen-Hao Lai, Li-Chen Chen, Tsung-Chieh Yao, Kuo-Wei Yeh, Jing-Long Huang
Few studies have addressed the mother-to-child transmission of Th2 immunity and the impact on the development of atopic diseases in early childhood. We investigated 186 children who were followed-up regularly for 4 years in a birth cohort study. The levels of Th2 related chemokine (C-C motif) ligand 17 (CCL17) and CCL22 were quantified in cord blood and at 1.5 years-of-age using multiplex Luminex kits. The levels of 125 pairs of CCL17 and CCL22 chemokines from birth to 1.5 years were recorded in this study...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29658572/pkr-inhibition-mediates-endotoxin-tolerance-in-macrophages-through-inactivation-of-pi3k-akt-signaling
#10
Hailin Xu, Juan Chen, Xiang Si, Minying Chen, Fei Pei, Chunfang Qiu, Jianfeng Wu, Xiangdong Guan
Following long‑term exposure to endotoxins, macrophages enter an immunosuppressive state that renders them unable respond to subsequent exposures to endotoxin, a phenomenon that is termed 'endotoxin tolerance'. Endotoxin tolerance increases the risks of secondary infection and mortality in patients with sepsis. In endotoxin‑tolerant macrophages, the mixed variation of gene transcription is referred to as macrophage reprogramming. The mechanisms underlying macrophage reprogramming remain unclear at present...
April 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29649105/glyteer-soybean-tar-impairs-il-4-stat6-signaling-in-murine-bone-marrow-derived-dendritic-cells-the-basis-of-its-therapeutic-effect-on-atopic-dermatitis
#11
Masaki Takemura, Takeshi Nakahara, Akiko Hashimoto-Hachiya, Masutaka Furue, Gaku Tsuji
Atopic dermatitis (AD) is a common inflammatory skin disease. Recent studies have revealed the involvement of T helper (Th)2 cytokines including Interleukin 4 (IL-4) in the pathogenesis of AD. Since epidermal Langerhans cells (LCs) and dermal myeloid dendritic cells (DCs) produce CCL17 and CCL22 that chemoattract Th2 cells, interfering with CCL17 and CCL22 production from LCs and dermal myeloid DCs may be beneficial in the treatment of AD. To investigate this, we stimulated murine bone marrow-derived DCs (BMDCs) with IL-4...
April 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29629429/il-33-drives-monocyte-recruitment-to-lung-interstitium-through-chemokine-upregulation
#12
Melissa Y Tjota, Daniel F Camacho, Heth R Turnquist, Anne I Sperling
Tissue infiltration by circulating monocytes is a critical step in the initiation and augmentation of type 2 inflammatory responses in the lungs. Our studies demonstrate that IL-33-/- mice have a defect in monocyte extravasation from the vasculature to the lung interstitium during induction of type 2 inflammatory responses. This result suggests that monocyte migration to the lungs is IL-33 dependent, and we found that administration of exogenous recombinant IL-33 is sufficient to restore monocyte localization to the lung interstitium...
August 1, 2017: ImmunoHorizons
https://www.readbyqxmd.com/read/29549623/tonsillitis-exacerbates-renal-injury-in-iga-nephropathy-through-promoting-th22-cells-chemotaxis
#13
Lu Gan, Mengyuan Zhu, Xiaozhao Li, Chen Chen, Ting Meng, Jiaxi Pu, Huiming Luo, Fengmin Shao, Qiaoling Zhou
BACKGROUND: Tonsillitis can promote the progression of IgA nephropathy (IgAN) by aggravating immunopathologic response. Th22 cell disorder is involved in the pathogenesis of IgAN with tonsillitis. This study was determined to explore the possible mechanism of IgAN with tonsillitis underlying Th22 cell chemotaxis response to the effect of CCL20, CCL22, and CCL27. METHODS: This research was conducted on 65 subjects including 16 healthy controls (HC group), 5 patients with  renal carcinoma (HTC group) and 44 patients with IgAN between 2015 and 2016...
March 16, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29520033/effects-of-low-molecular-weight-heparin-on-the-polarization-and-cytokine-profile-of-macrophages-and-t-helper-cells-in-vitro
#14
Valentina Bruno, Judit Svensson-Arvelund, Marie Rubér, Göran Berg, Emilio Piccione, Maria C Jenmalm, Jan Ernerudh
Low molecular weight heparin (LMWH) is widely used in recurrent miscarriage treatment. The anti-coagulant effects are established, while immunological effects are not fully known. Our aim was to assess LMWH effects on activation and polarization of central regulatory immune cells from healthy women, and on placenta tissues from women undergoing elective abortions. Isolated blood monocytes and T helper (Th) cells under different activation and polarizing conditions were cultured with or without LMWH. Flow cytometry showed that LMWH exposure induced increased expression of HLA-DR and CD206 in macrophages...
March 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29519579/a-ccr4-antagonist-enhances-dc-activation-and-homing-to-the-regional-lymph-node-and-shows-potent-vaccine-adjuvant-activity-through-the-inhibition-of-regulatory-t-cell-recruitment
#15
Shinya Yamamoto, Kazuhiko Matsuo, Daisuke Nagakubo, Shintaro Higashiyama, Keiji Nishiwaki, Naoki Oiso, Akira Kawada, Osamu Yoshie, Takashi Nakayama
CCR4 is a major chemokine receptor expressed by Treg cells that downregulate immune responses. Here, we investigated the role of CCR4-mediated Treg cell recruitment in antigen-specific immune responses. CCR4-deficient mice immunized intramuscularly with ovalbumin (OVA) showed enhanced OVA-specific IgG responses. Furthermore, intramuscular administration of OVA induced the expression of MDC/CCL22, a ligand for CCR4, in macrophages of the muscle tissues, and enhanced the recruitment of CCR4+ Treg cells in wild-type mice, whereas this recruitment of Treg cells was severely impaired in CCR4-deficient mice...
March 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29510192/ccr4-is-critically-involved-in-skin-allergic-inflammation-of-balb-c-mice
#16
Kazuhiko Matsuo, Daisuke Nagakubo, Yuhei Komori, Shun Fujisato, Natsumi Takeda, Mizuki Kitamatsu, Keiji Nishiwaki, Ying-Shu Quan, Fumio Kamiyama, Naoki Oiso, Akira Kawada, Osamu Yoshie, Takashi Nakayama
Atopic dermatitis is a chronic inflammatory skin disease involving T-helper (Th) 2 cells, eosinophils, and mast cells. Although CCR4 is a major chemokine receptor expressed on Th2 cells and regarded as a potential therapeutic target for allergic diseases, its role in atopic dermatitis remains unclear. Here, by using a hydrogel patch as a transcutaneous delivery device for ovalbumin (an antigen) and Staphylococcus aureus δ-toxin (a mast cell activator), we efficiently induced acute atopic dermatitis-like skin lesions in BALB/c mice, a strain prone to Th2 responses, which were characterized by increased numbers of eosinophils, mast cells, and CCR4-expressing Th2 cells in the skin lesions; elevated levels of total and ovalbumin-specific IgE in the sera; and increased expression of IL-4, IL-17A, IL-22, CCL17, CCL22, and CCR4 in the skin lesions...
March 3, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29504848/signalling-pathways-identified-in-salivary-glands-from-primary-sj%C3%A3-gren-s-syndrome-patients-reveal-enhanced-adipose-tissue-development
#17
Lara A Aqrawi, Janicke Liaaen Jensen, Gunnvor Øijordsbakken, Ann-Kristin Ruus, Ståle Nygård, Marit Holden, Roland Jonsson, Hilde Kanli Galtung, Kathrine Skarstein
A characteristic feature of primary Sjögren's syndrome (pSS) is the destruction of salivary and lacrimal glands mediated by mononuclear cell infiltration. Adipocytes can also occupy a large portion of the salivary gland (SG) tissue area, although little is known about their significance in pSS. We have previously investigated adipose tissue infiltration in SG biopsies from pSS patients and non-SS sicca controls. Our findings indicated the distinct incidence of adipose tissue replacement in pSS patients, where adipocytes were detected in interleukin (IL) 6 rich regions...
May 2018: Autoimmunity
https://www.readbyqxmd.com/read/29485045/blocking-interleukin-il-4-and-il13-mediated-phosphorylation-of-stat6-tyr641-decreases-m2-polarization-of-macrophages-and-protects-against-macrophage-mediated-radioresistance-of-inflammatory-breast-cancer
#18
Omar M Rahal, Adam R Wolfe, Pijus K Mandal, Richard Larson, Sanda Tin, Cristina Jimenez, Dadong Zhang, Janet Horton, James M Reuben, John S McMurray, Wendy A Woodward
PURPOSE: To determine the role of macrophage polarization on the response of inflammatory breast cancer (IBC) cells to radiation and whether modulation of macrophage plasticity can alter radiation response. METHODS AND MATERIALS: The human THP-1 monocyte cell line and primary human monocytes isolated from peripheral blood mononuclear cells were differentiated into macrophages and polarized to either an "antitumor" (M1) or a "protumor" (M2) phenotype...
March 15, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29477032/3d-3-culture-a-tool-to-unveil-macrophage-plasticity-in-the-tumour-microenvironment
#19
Sofia P Rebelo, Catarina Pinto, Tatiana R Martins, Nathalie Harrer, Marta F Estrada, Pablo Loza-Alvarez, José Cabeçadas, Paula M Alves, Emilio J Gualda, Wolfgang Sommergruber, Catarina Brito
The tumour microenvironment (TME) shapes disease progression and influences therapeutic response. Most aggressive solid tumours have high levels of myeloid cell infiltration, namely tumour associated macrophages (TAM). Recapitulation of the interaction between the different cellular players of the TME, along with the extracellular matrix (ECM), is critical for understanding the mechanisms underlying disease progression. This particularly holds true for prediction of therapeutic response(s) to standard therapies and interrogation of efficacy of TME-targeting agents...
May 2018: Biomaterials
https://www.readbyqxmd.com/read/29463257/cerium-oxide-and-barium-sulfate-nanoparticle-inhalation-affects-gene-expression-in-alveolar-epithelial-cells-type-ii
#20
Daniela Schwotzer, Monika Niehof, Dirk Schaudien, Heiko Kock, Tanja Hansen, Clemens Dasenbrock, Otto Creutzenberg
BACKGROUND: Understanding the molecular mechanisms of nanomaterial interacting with cellular systems is important for appropriate risk assessment. The identification of early biomarkers for potential (sub-)chronic effects of nanoparticles provides a promising approach towards cost-intensive and animal consuming long-term studies. As part of a 90-day inhalation toxicity study with CeO2 NM-212 and BaSO4 NM-220 the present investigations on gene expression and immunohistochemistry should reveal details on underlying mechanisms of pulmonary effects...
February 20, 2018: Journal of Nanobiotechnology
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