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Langerhans dendritic cells

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https://www.readbyqxmd.com/read/29743654/expression-of-the-transcription-factor-zbtb46-distinguishes-human-histiocytic-disorders-of-classical-dendritic-cell-origin
#1
Ansuman T Satpathy, Ryanne A Brown, Ellen Gomulia, Carlos G Briseño, Maxwell R Mumbach, Zenggang Pan, Kenneth M Murphy, Yasodha Natkunam, Howard Y Chang, Jinah Kim
Distinguishing classical dendritic cells from other myeloid cell types is complicated by the shared expression of cell surface markers. ZBTB46 is a zinc finger and BTB domain-containing transcription factor, which is expressed by dendritic cells and committed dendritic cell precursors, but not by plasmacytoid dendritic cells, monocytes, macrophages, or other immune cell populations. In this study, we demonstrate that expression of ZBTB46 identifies human dendritic cell neoplasms. We examined ZBTB46 expression in a range of benign and malignant histiocytic disorders and found that ZBTB46 is able to clearly define the dendritic cell identity of many previously unclassified histiocytic disease subtypes...
May 9, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29723162/hiv-1-replicates-and-persists-in-vaginal-epithelial-dendritic-cells
#2
Victor Pena-Cruz, Luis M Agosto, Hisashi Akiyama, Alex Olson, Yvetane Moreau, Jean-Robert Larrieux, Andrew Henderson, Suryaram Gummuluru, Manish Sagar
HIV-1 acquisition occurs most commonly after sexual contact. To establish infection, HIV-1 must infect cells that support high level replication, namely CD4+ T cells, which are absent from the outermost genital epithelium. Dendritic cells (DCs), present in mucosal epithelia, potentially facilitate HIV-1 acquisition. We show that vaginal epithelial DCs, termed CD1a+ VEDCs, are unlike other blood and tissue derived DCs because they express langerin but not DC-SIGN, and unlike skin-based langerin+ DC subset, Langerhans cells (LC), they do not harbor Birbeck granules...
May 3, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29717663/runx3-mediated-immune-cell-development-and-maturation
#3
Pal Boto, Tamas Imre Csuth, Istvan Szatmari
The transcription factor RUNX3 is a prominent regulator of multiple hematopoietic cell lineages. Gene loss of function studies demonstrated the unique and essential roles of this master regulator in differentiated lymphoid and myeloid cells. As a complementary approach, RUNX3 was upregulated in various leukocyte subsets to probe the instructive role of this 'multilineage'-specific transcription factor. In this report, we overview the immunomodulatory functions of RUNX3 within the hematopoietic compartment to gain insight into the consequences of Runx3 deletion or overexpression in committed immune cells...
2018: Critical Reviews in Immunology
https://www.readbyqxmd.com/read/29691886/cutaneous-langerhans-cell-histiocytosis-presenting-with-hypopigmented-lesions-report-of-two-cases-and-review-of-literature
#4
Shoko Mori, Tony Adar, Viktoryia Kazlouskaya, Jaime B Alexander, Edward Heilman, Sharon A Glick
Langerhans cell histiocytosis is a rare group of disorders that results from the abnormal proliferation and accumulation of dendritic-derived cells in various organs of the body, such as the skin and bones. Hypopigmented macules are a rare cutaneous presentation of Langerhans cell histiocytosis that may pose a diagnostic dilemma when no other findings of Langerhans cell histiocytosis are present at the time of examination. We present 2 cases of the hypopigmented variant of Langerhans cell histiocytosis, including a case with histopathologic features of regression, and a review of the literature...
April 25, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29673124/liquid-based-cytology-in-the-diagnosis-of-langerhans-cell-sarcoma-a-case-report
#5
Kazumi Iwasaki, Yasuhiro Sakai, Masaki Mori, Yoshiaki Imamura
Langerhans cell sarcoma (LCS) is an extremely rare malignant dendritic cell neoplasm with Langerhans cell differentiation. Conventional cytology, based on cell morphology alone, cannot render a cytological diagnosis of LCS because immunochemical analysis is essential to identify the Langerhans cell immunophenotype. We present a case illustrating the value of liquid-based cytology with immunocytochemistry as compared with conventional cytology, along with histological and immunohistochemical findings. A 92-year-old woman presented with a 1-month history of progressive right cervical lymphadenopathy...
April 19, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29672867/langerhans-and-inflammatory-dendritic-epidermal-cells-in-atopic-dermatitis-are-tolerized-towards-tlr2-activation
#6
Kazumasa Iwamoto, Tim J Stroisch, Susanne Koch, Nadine Herrmann, Nicole Leib, Thomas Bieber
BACKGROUND: The skin of atopic dermatitis (AD) patients presents a significant dysbalance of the microbiome with a high colonization by Staphylococcus aureus (S. aureus) which positively correlates with the severity of the disease. OBJECTIVE: Understanding the role of epidermal dendritic cells as link between the innate and the adaptive immune systems in AD. METHODS: Comparative phenotypic and functional analysis of TLR2 on Langerhans cells (LC) and inflammatory dendritic epidermal cells (IDEC) in organotypic models as well as freshly isolated cells from healthy and AD skin...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29655588/resident-and-monocyte-derived-langerhans-cells-are-required-for-imiquimod-induced-psoriasis-like-dermatitis-model
#7
Minseok Lee, Sung Hee Kim, Tae-Gyun Kim, Jeyun Park, Jae Won Lee, Min-Geol Lee
BACKGROUND: Langerhans cells (LCs) are dendritic cells that reside in the epidermis and local inflammation results in an increased differentiation of monocyte-derived LCs. Only few studies have investigated on the role of LCs in psoriasis-like dermatitis model, but the results are variable and the exact role of LCs in psoriasis model remains to be elucidated. OBJECTIVE: To explore the functional role of resident (rLCs) and monocyte-derived LCs (mLCs) in imiquimod (IMQ)-induced psoriasis-like inflammation using human Langerin-diphtheria toxin subunit A (huLang-DTA) mice...
April 6, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29649105/glyteer-soybean-tar-impairs-il-4-stat6-signaling-in-murine-bone-marrow-derived-dendritic-cells-the-basis-of-its-therapeutic-effect-on-atopic-dermatitis
#8
Masaki Takemura, Takeshi Nakahara, Akiko Hashimoto-Hachiya, Masutaka Furue, Gaku Tsuji
Atopic dermatitis (AD) is a common inflammatory skin disease. Recent studies have revealed the involvement of T helper (Th)2 cytokines including Interleukin 4 (IL-4) in the pathogenesis of AD. Since epidermal Langerhans cells (LCs) and dermal myeloid dendritic cells (DCs) produce CCL17 and CCL22 that chemoattract Th2 cells, interfering with CCL17 and CCL22 production from LCs and dermal myeloid DCs may be beneficial in the treatment of AD. To investigate this, we stimulated murine bone marrow-derived DCs (BMDCs) with IL-4...
April 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29621879/recurrent-indeterminate-dendritic-cell-tumor-of-the-skin
#9
Jin Woo Joo, Taek Chung, Yoon Ah Cho, Sang Kyum Kim
Indeterminate dendritic cell tumor (IDCT) is a dendritic cell tumor that displays histologic features similar to those of Langerhans cells. The origin of the indeterminate cells may represent precursors of Langerhans cells or skin dendritic cells. IDCT is extremely rare, and tumor progression and predictive factors are not well known. Here, we report a case of a 61-year-old man who presented with a papule on his back and was finally diagnosed with IDCT based on histology and immunohistochemistry. The tumor recurred months after surgical excision...
April 5, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29616031/the-impact-of-the-epithelial-mesenchymal-transition-regulator-hepatocyte-growth-factor-receptor-met-on-skin-immunity-by-modulating-langerhans-cell-migration
#10
REVIEW
Zsofia Sagi, Thomas Hieronymus
Langerhans cells (LCs), the epidermal dendritic cell (DC) subset, express the transmembrane tyrosine kinase receptor Met also known as hepatocyte growth factor (HGF) receptor. HGF is the exclusive ligand of Met and upon binding executes mitogenic, morphogenic, and motogenic activities to various cells. HGF exerts anti-inflammatory activities via Met signaling and was found to regulate various functions of immune cells, including differentiation and maturation, cytokine production, cellular migration and adhesion, and T cell effector function...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29610553/preventive-effect-of-dioscorea-japonica-on-squamous-cell-carcinoma-of-mouse-skin-involving-down-regulation-of-prostaglandin-e-2-synthetic-pathway
#11
Izumi Tsukayama, Keisuke Toda, Yasunori Takeda, Takuto Mega, Mitsuki Tanaka, Yuki Kawakami, Yoshitaka Takahashi, Masumi Kimoto, Kei Yamamoto, Yoshimi Miki, Makoto Murakami, Toshiko Suzuki-Yamamoto
Hyperproduced prostaglandin E2 by cyclooxygenase-2 and microsomal prostaglandin E synthase-1 evokes several pathophysiological responses such as inflammation and carcinogenesis. Our recent study demonstrated that Dioscorea japonica extract suppressed the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 and induced apoptosis in lung carcinoma A549 cells. In the present study, we investigated the effects of Dioscorea japonica on squamous cell carcinoma of mouse skin. Dioscorea japonica feeding and Dioscorea japonica extract topical application suppressed the expression of cyclooxygenase-2, microsomal prostaglandin E synthase-1, interleukin-1β and interleukin-6 and inhibited tumor formation, hyperplasia and inflammatory cell infiltration...
March 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29599667/langerhans-cell-histiocytosis-in-children-a-disease-with-many-faces-recent-advances-in-pathogenesis-diagnostic-examinations-and-treatment
#12
REVIEW
Michalina Jezierska, Joanna Stefanowicz, Grzegorz Romanowicz, Wojciech Kosiak, Magdalena Lange
Langerhans cell histiocytosis is a rare clonal disease characterized by the proliferation of CD1a-positive immature dendritic cells. The purpose of this article was to present an updated review of recent advances in the pathogenesis, clinical features, imaging and treatment of this disease. The discovery of oncogenic BRAF mutations and the presence of proinflammatory cytokines and chemokines confirmed the unusual characteristics of this disease. Currently, children with organ involvement who do not have a good response to chemotherapy and have neurodegeneration or diabetes insipidus are the most problematic patients...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29557616/-langerhans-cell-histiocytosis-with-orbital-involvement-in-an-infant-case-report
#13
Alma V Huidobro-Chávez, Gianmarco D Vigo Pareja, Carlos Pachas-Peña, Karina Patiño-Calla
The Langerhans cell histiocytosis is a rare disease characterized by the clonal proliferation of CD1a + myeloid dendritic cells associated with a significant inflammatory component. The localized form of the disease is called eosinophilic granuloma. Bone involvement is common; in children, lytic lesions are most frequently found in the cranial dome being rare in the orbit. We present an 18-month-old infant who consulted due to periorbital edema and proptosis of the right eye, with two months of evolution. The computed tomography and the magnetic resonance imaging showed a maxillary sinus tumor mass of expansive growth and erosion of the roof of the orbit...
April 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29535261/p38%C3%AE-signaling-in-langerhans-cells-promotes-the-development-of-il-17-producing-t-cells-and-psoriasiform-skin-inflammation
#14
Tingting Zheng, Weiheng Zhao, Hongjin Li, Shuxiu Xiao, Ran Hu, Miaomiao Han, Heng Liu, Yeqiang Liu, Kinya Otsu, Xinguang Liu, Gonghua Huang
Dendritic cells (DCs) contribute to psoriasis pathogenesis. In a mouse model of imiquimod-induced psoriasiform skin inflammation, we found that p38α activity in Langerhans cells (LCs), a skin-resident subset of DCs, promoted the generation of T cells that produce IL-17, a proinflammatory cytokine that is implicated in autoimmune disease. Deletion of p38α in LCs, but not in other skin or circulating DC subsets or T cells, decreased T cell-mediated psoriasiform skin inflammation in mice. The activity of p38α in LCs specifically promoted IL-17 production from γδ and CD4+ T cells by increasing the abundance of IL-23 and IL-6, two cytokines that stimulate IL-17 secretion...
March 13, 2018: Science Signaling
https://www.readbyqxmd.com/read/29526544/molecular-characterization-of-the-histiocytoses-neoplasia-of-dendritic-cells-and-macrophages
#15
REVIEW
Benjamin H Durham
The systemic histiocytoses encompass a clinically heterogeneous group of disorders leading to tissue damage secondary to the accumulation and infiltration of pathological cells thought to be derived from the dendritic or monocytic lineages with accompanying inflammation. For decades, whether or not the histiocytoses were inflammatory or neoplastic disorders was unclear, and their cellular origins have long been obscure and heavily debated. However, the rise of the molecular era led to the discovery of recurrent BRAFV600E mutations in approximately 50% of patients with Langerhans cell and non-Langerhans cell histiocytoses, which provided the first convincing evidence that these are indeed histiocytic neoplasms...
March 16, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29470255/clinical-implications-of-oncogenic-mutations-in-pulmonary-langerhans-cell-histiocytosis
#16
Noah A Brown, Kojo S J Elenitoba-Johnson
PURPOSE OF REVIEW: Langerhans cell histiocytosis (LCH) is a neoplasm of dendritic cells with a wide clinical spectrum. Localized pulmonary LCH occurs in young adults with a history of smoking and can either resolve spontaneously or lead to progressive decline in pulmonary function. Young children can also present with localized disease - frequently bone or skin - or with multifocal or multisystem disease. Clinical outcomes in these patients also vary widely, ranging from spontaneous resolution to multiorgan failure and death...
May 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29468275/-the-innate-immune-system-in-oropharyngeal-squamous-cell-carcinoma-immune-modulation-by-hpv
#17
REVIEW
S Wagner, H Böckmann, S Gattenlöhner, J P Klussmann, C Wittekindt
Based on clinical and experimental data, oropharyngeal squamous cell carcinomas (OPSCC) associated with human papillomavirus (HPV) have been recognized as a distinct entity of head and neck cancers. However, outside of clinical trials, HPV status currently has no impact on treatment. The natural replication cycle of HPV takes place in epithelial cells, and is thus spatially separated from cytotoxic immune cells in the epidermis. Dendritic cells (Langerhans cells, LC), however, are frequent in this upper dermal layer...
April 2018: HNO
https://www.readbyqxmd.com/read/29468064/the-multiple-faces-of-langerhans-cell-histiocytosis-in-childhood-a-gentle-reminder
#18
Maria Papadopoulou, Paraskevi Panagopoulou, Anastasia Papadopoulou, Emmanuel Hatzipantelis, Ioannis Efstratiou, Assimina Galli-Tsinopoulou, Efimia Papadopoulou-Alataki
Langerhans cell histiocytosis (LCH) is a rare hematologic disorder that results from the clonal multiplication and accumulation of immature dendritic Langerhans cells. Its reported incidence rate varies, but is considered to be 2.6-8.9 per million children who are <15 years of age each year. It may affect any system or organ. The present study reported 4 pediatric LCH cases in order to highlight the heterogeneity of the initial presentation, and the pitfalls that may mislead clinicians and delay diagnosis...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29449841/langerhans-cells-sensing-the-environment-in-health-and-disease
#19
REVIEW
Julie Deckers, Hamida Hammad, Esther Hoste
In the last few decades, our understanding of Langerhans cells (LCs) has drastically changed based on novel findings regarding the developmental origin and biological functions of these epidermis-specific resident immune cells. It has become clear that LCs not only exert pivotal roles in immune surveillance and homeostasis but also impact on pathology by either inducing tolerance or mediating inflammation. Their unique capabilities to self-renew within the epidermis, while also being able to migrate to lymph nodes in order to present antigen, place LCs in a key position to sample the local environment and decide on the appropriate cutaneous immune response...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29448069/micro-environmental-signals-directing-human-epidermal-langerhans-cell-differentiation
#20
REVIEW
Herbert Strobl, Corinna Krump, Izabela Borek
Human Langerhans cells (LC) can be generated ex vivo from hematopoietic precursor cells in response to cytokines and cell-membrane associated ligands. These in vitro differentiation models provided mechanistic insights into the molecular and cellular pathways underlying the development of this unique, epithelia-associated dendritic cell subset. Notably, the human epidermal microenvironment is fully sufficient to induce LC differentiation from hematopoietic progenitors. Hence, dissecting the molecular characteristics of the human epithelial/epidermal LC niche, and testing defined ligands for their capacity to induce LC differentiation, led to a refined molecular model of LC lineage commitment...
February 23, 2018: Seminars in Cell & Developmental Biology
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