Anas Alrohimi, David Z Rose, W Scott Burgin, Swetha Renati, Nicholas Corbin Hilker, Wei Deng, Guilherme H Oliveira, Theresa M Beckie, Arthur J Labovitz, Michael G Fradley, Nhi Tran, Laura C Gioia, Mahesh Kate, Kelvin Ng, Dar Dowlatshahi, Thalia S Field, Shelagh B Coutts, Muzzafar Siddiqui, Michael D Hill, Jodi Miller, Glen Jickling, Ashfaq Shuaib, Brian Buck, Mike Sharma, Ken S Butcher
INTRODUCTION: Precise risk of hemorrhagic transformation (HT) in acute ischemic stroke (AIS) remains unknown, leading to delays in anticoagulation initiation for secondary stroke prevention. We sought to assess the rate of HT associated with direct oral anticoagulant (DOAC) initiation within and beyond 48 h post-AIS. METHODS: A pooled analysis of DOAC initiation within 14 days of AIS or transient ischemic attack (TIA) was conducted with six studies (four prospective open label treatment, blinded outcome studies and two randomized trials; NCT02295826 and NCT02283294)...
March 26, 2023: International Journal of Stroke: Official Journal of the International Stroke Society