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Leucopenia

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https://www.readbyqxmd.com/read/28339702/subclinical-chronic-left-ventricular-systolic-dysfunction-resulting-from-phosphine-poisoning
#1
E Szymczyk, M Wiszniewska, J Walusiak-Skorupa, J D Kasprzak, P Lipiec
We present a case of a 32-year-old male crew member of a cargo ship, accidentally exposed to phosphine, a fumigating substance. He and other crew members developed increasing fatigue and digestive disorders 24 h later; two died from acute pulmonary oedema. The patient was admitted to hospital, where bilateral pneumonia, acute nephritis, hepatopathy, electrolyte imbalance and leucopenia were diagnosed. He was discharged from hospital 3 weeks later. He was examined 4 months later for possible chronic consequences of acute phosphine poisoning, which included echocardiography showing normal heart size and cardiac function...
February 21, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28331021/aspergillus-niger-infection-in-an-immunosuppressed-patient-confined-solely-to-the-brain
#2
Lucy Simmonds, Sian Mitchell, Barrie White, Shanika A Crusz, David Denning
A 68-year-old woman with a background of hypertension, stroke and rheumatoid arthritis presented to her local hospital after a 4-week history of gradual deterioration and increasing confusion with new onset right-sided weakness. Her initial CT scan revealed a rim enhancing mass lesion with surrounding oedema in the left parietal lobe for which she underwent CT stealth-guided biopsy. Microbiology culture of the 2 biopsy samples yielded Aspergillus niger and she was started on the antifungal agent voriconazole...
March 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28321611/iron-deficiency-and-iron-deficiency-anemia-in-3-5-months-old-breastfed-healthy-infants
#3
Sudarsan Krishnaswamy, Dharmagat Bhattarai, Bhavneet Bharti, Prateek Bhatia, Reena Das, Deepak Bansal
OBJECTIVE: To assess the prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) in predominantly breastfed, 3-5-mo-old infants, born at term, with a birth weight ≥ 2.5 kg. METHODS: The cross-sectional study was conducted in the outpatient department of a tertiary care center from January 2013 through December 2014. INCLUSION CRITERIA: Age: 90-180 d, exclusively/predominantly breastfed, birth weight ≥ 2.5 kg and term gestation...
March 21, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28302147/soil-transmitted-helminths-and-plasmodium-falciparum-malaria-among-individuals-living-in-different-agroecosystems-in-two-rural-communities-in-the-mount-cameroon-area-a-cross-sectional-study
#4
Irene Ule Ngole Sumbele, Gladys Belanka Nkemnji, Helen Kuokuo Kimbi
BACKGROUND: Soil-transmitted helminths (STHs) and Plasmodium falciparum infections remain public health problems in Cameroon. A cross-sectional study was carried out in the Mount Cameroon area to determine the prevalence and intensity of STHs and P. falciparum infections in individuals living in different agroecosystems; to assess the influence of these infections on haematological parameters; and to identify the risk factors associated with STH infections. METHODS: STH and malaria parasites were detected using the Kato-Katz method and Giemsa staining of blood films, respectively...
March 16, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28296744/hypouricemic-and-arthritis-relapse-reducing-effects-of-compound-tufuling-oral-liquid-in-intercritical-and-chronic-gout-a-double-blind-placebo-controlled-multicenter-randomized-trial
#5
Zhijun Xie, Huaxiang Wu, Xiaoqing Jing, Xiuyang Li, Yasong Li, Yongmei Han, Xiangfu Gao, Xiaopo Tang, Jing Sun, Yongshen Fan, Chengping Wen
TRIAL DESIGN: In the double-blind, randomized, controlled trial, we aimed to evaluate the effects of compound tufuling oral liquid (CoTOL) on serum uric acid (sUA) levels and recurrence of acute gouty arthritis in intercritical and chronic gout treatment. METHODS: A total of 210 patients with gout were screened from 8 hospitals to observe the sUA and acute gouty arthritis recurrence rate-reducing effects of CoTOL in intercritical and chronic gout during a 12-week treatment...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28272679/clinicopathological-features-of-bone-marrow-infiltration-in-hodgkin-lymphoma-should-bone-marrow-staging-be-done-only-in-high-risk-patients
#6
Muthu Sudalaimuthu, Debdatta Basu
OBJECTIVE: The frequency of bone marrow infiltration by Hodgkin lymphoma is low and varies from 3 to 18%. Hence there exists a dilemma whether bone marrow staging should be done only in the high risk cases. This study aims to study the clinicopathological features and the histomorphology of bone marrow infiltration by Hodgkin Lymphoma. MATERIAL AND METHOD: Bone marrow aspirates and biopsies from cases of Hodgkin lymphoma diagnosed between 2007 and 2015 were studied...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28260458/successful-cost-effective-prevention-of-cytomegalovirus-disease-in-kidney-transplant-recipients-using-low-dose-valganciclovir
#7
Osama Gheith, Medhat A Halim, Torki Al-Otaibi, Hany Mansour, Ahmed Mosaad, Hassanein Abo Atteya, Zakaria Zakaria, Tarek Said, Prasad Nair, Narayanam Nampoory
OBJECTIVES: Low-dose valganciclovir prophylaxis is still under investigation in renal transplant procedures. Our aim was to assess the cost effectiveness of 450 mg versus 900 mg valganciclovir prophylaxis in kidney transplant recipients. MATERIALS AND METHODS: In this prospective trial, 201 kidney transplant patients were randomized (1:1) to receive 450 mg/d (group 1, n = 100) or 900 mg/d (group 2, n = 101) valganciclovir prophylaxis for the first 6 months after transplant...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28259610/vandetanib-plus-gemcitabine-versus-placebo-plus-gemcitabine-in-locally-advanced-or-metastatic-pancreatic-carcinoma-vip-a-prospective-randomised-double-blind-multicentre-phase-2-trial
#8
Gary Middleton, Daniel H Palmer, William Greenhalf, Paula Ghaneh, Richard Jackson, Trevor Cox, Anthony Evans, Victoria E Shaw, Jonathan Wadsley, Juan W Valle, David Propper, Harpreet Wasan, Stephen Falk, David Cunningham, Fareeda Coxon, Paul Ross, Srinivasan Madhusudan, Nick Wadd, Pippa Corrie, Tamas Hickish, Eithne Costello, Fiona Campbell, Charlotte Rawcliffe, John P Neoptolemos
BACKGROUND: Erlotinib is an EGFR tyrosine kinase inhibitor that has shown a significant but only marginally improved median overall survival when combined with gemcitabine in patients with locally advanced and metastatic pancreatic cancer. Vandetanib is a novel tyrosine kinase inhibitor of VEGFR2, RET, and EGFR, all of which are in involved in the pathogenesis of pancreatic cancer. We investigated the clinical efficacy of vandetanib when used in combination with gemcitabine in patients with advanced pancreatic cancer...
March 1, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28236583/progression-free-survival-of-early-interim-pet-positive-patients-with-advanced-stage-hodgkin-s-lymphoma-treated-with-beacoppescalated-alone-or-in-combination-with-rituximab-hd18-an-open-label-international-randomised-phase-3-study-by-the-german-hodgkin-study
#9
Peter Borchmann, Heinz Haverkamp, Andreas Lohri, Ulrich Mey, Stefanie Kreissl, Richard Greil, Jana Markova, Michaela Feuring-Buske, Julia Meissner, Ulrich Dührsen, Helmut Ostermann, Ulrich Keller, Georg Maschmeyer, Georg Kuhnert, Markus Dietlein, Carsten Kobe, Hans Eich, Christian Baues, Harald Stein, Michael Fuchs, Volker Diehl, Andreas Engert
BACKGROUND: Advanced stage Hodgkin's lymphoma represents a heterogeneous group of patients with different risk profiles. Data suggests that interim PET assessment during chemotherapy is superior to baseline international prognostic scoring in terms of predicting long-term treatment outcome in patients with Hodgkin's lymphoma. We therefore hypothesised that early interim PET-imaging after two courses of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) might be suitable for guiding treatment in patients with advanced stage Hodgkin's lymphoma...
February 21, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28229289/clinical-aspects-of-hantavirus-infections-in-bulgaria
#10
I Christova, M Pishmisheva, I Trifonova, N Vatev, M Stoycheva, M Tiholova, D Igova, M Baev, R Karagyaurova, U Prokopova
BACKGROUND: Hantaviruses cause two distinct human diseases: hemorrhagic fever with renal syndrome (HFRS) in Asia and Europe and hantavirus pulmonary syndrome (HPS) in America. In Europe, mainly Puumala, Dobrava and Seoul viruses cause HFRS. A total of 23 cases of HFRS were detected in Bulgaria over a 2‑year period 2013-2014. The aim of the study was to present epidemiology, clinical manifestations and laboratory findings of these patients. METHODS: Patients with HFRS were diagnosed using PCR, ELISA and immunoblotting tests...
February 22, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28225501/the-effect-of-induction-chemotherapy-in-patients-with-locally-advanced-nonsmall-cell-lung-cancer-who-received-chemoradiotherapy-a-systematic-review-and-meta-analysis
#11
REVIEW
Hui Luo, Xinshuang Yu, Ning Liang, Jian Xie, Guodong Deng, Qiqi Liu, Jingxin Zhang, Jiandong Zhang, Hong Ge
BACKGROUND: The efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) in patients with locally advanced nonsmall cell lung cancer (NSCLC) is unclear, we performed a systematic review and meta-analysis of published papers to quantitatively evaluate the potential benefit of induction chemotherapy. METHODS: Eligible studies of induction chemotherapy and chemoradiotherapy were retrieved through extensive searches of the PubMed, Science Direct, Embase, and Cochrane library databases from 1994 to 2015...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28213683/phase-ii-study-of-bevacizumab-and-irinotecan-as-second-line-therapy-for-patients-with-metastatic-colorectal-cancer-previously-treated-with-fluoropyrimidines-oxaliplatin-and-bevacizumab
#12
Hidekazu Kuramochi, Masayuki Ando, Michio Itabashi, Go Nakajima, Kazuyuki Kawakami, Mie Hamano, Eiichi Hirai, Hajime Yokomizo, Ryuji Okuyama, Tatsuo Araida, Kazuhiko Yoshimatsu, Shingo Kameoka, Kazuhiko Hayashi
PURPOSE: Fluorouracil and folinic acid with irinotecan (FOLFIRI) plus bevacizumab (BV) is widely used as second-line chemotherapy for patients with metastatic colorectal cancer (mCRC) previously treated with fluoropyrimidines, oxaliplatin, and BV. FOLFIRI requires a CV catheter and an infusion pump, which are inconvenient for patients. Sufficient data are not available for characterizing the effectiveness of fluoropyrimidines beyond first disease progression. In this study, we evaluated the efficacy and safety of irinotecan (CPT-11) plus BV as second-line therapy...
February 17, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28211785/continuous-infusion-of-a-large-dose-of-cf-and-5-fu-combined-with-cddp-in-the-treatment-of-advanced-esophageal-cancer
#13
Zheng-Qiu Zhu, Zu-An Zhu, Hong-Xing Cai
5-fluorouracil (5-FU) and cisplatin (CDDP) are common chemotherapy drugs used in the treatment of patients with advanced esophageal cancer. We investigated the efficacy of adding a continuous infusion of a large dose of a common adjuvant, citrovorumfactor (CF), to the traditional 5-FU/wCDDP regimen. 50 patients with advanced esophageal cancer were treated with a continuous infusion of CF, 5-FU, and CDDP, and the short-term effects, adverse reactions, and survival periods after treatment were analyzed. Overall, the treatment was effective in 58% of patients, and the therapeutic effects of the first-line of chemotherapy were significantly better than the second-line (u = 4...
February 17, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28211482/neoadjuvant-chemotherapy-followed-by-concurrent-chemoradiotherapy-versus-concurrent-chemoradiotherapy-alone-in-nasopharyngeal-carcinoma-patients-with-cervical-nodal-necrosis
#14
Mei Lan, Chunyan Chen, Ying Huang, Li Tian, Zhijun Duan, Fei Han, Junfang Liao, Meiling Deng, Terence T Sio, Anussara Prayongrat, Lie Zheng, Shaoxiong Wu, Taixiang Lu
The effectiveness of neoadjuvant chemotherapy (NACT) followed by concurrent chemoradiotherapy (CCRT) compared with CCRT alone in nasopharyngeal carcinoma (NPC) patients who presented with cervical nodal necrosis (CNN) is unknown. A total of 792 patients with stage T1-4N1-3M0 NPC and presented with CNN based on magnetic resonance imaging were retrospectively reviewed. Propensity score matching method was used to balance treatment arms for baseline characteristics. Eventually, 508 patients were propensity-matched on a 1:1 basis to create two groups (NACT + CCRT and CCRT groups)...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28188818/jnk1-2-inhibitor-reduces-dengue-virus-induced-liver-injury
#15
Gopinathan Pillai Sreekanth, Aporn Chuncharunee, Boonyarit Cheunsuchon, Sansanee Noisakran, Pa-Thai Yenchitsomanus, Thawornchai Limjindaporn
High viral load with liver injury is exhibited in severe dengue virus (DENV) infection. Mitogen activated protein kinases (MAPKs) including ERK1/2 and p38 MAPK were previously found to be involved in the animal models of DENV-induced liver injury. However, the role of JNK1/2 signaling in DENV-induced liver injury has never been investigated. JNK1/2 inhibitor, SP600125, was used to investigate the role of JNK1/2 signaling in the BALB/c mouse model of DENV-induced liver injury. SP600125-treated DENV-infected mice ameliorated leucopenia, thrombocytopenia, hemoconcentration, liver transaminases and liver histopathology...
February 7, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28184306/effect-of-malaria-infection-on-hematological-profiles-of-people-living-with-human-immunodeficiency-virus-in-gambella-southwest-ethiopia
#16
Tsion Sahle, Tilahun Yemane, Lealem Gedefaw
BACKGROUND: Malaria and human immunodeficiency virus are the two most devastating global health problems causing more than two million deaths each year. Hematological abnormalities such as anemia, thrombocytopenia and leucopenia are the common complications in malaria and HIV co-infected individuals. The aim of this study was to determine the effect of malaria infection on hematological profiles of people living with HIV attending Gambella Hospital ART clinic, Southwestern Ethiopia. OBJECTIVE: To determine the effect of malaria infection on hematological profiles of people living with HIV attending Gambella Hospital ART clinic, Southwestern Ethiopia...
2017: BMC Hematology
https://www.readbyqxmd.com/read/28182264/relative-risk-of-and-determinants-for-adverse-events-of-methotrexate-prescribed-at-a-low-dose-a-systematic-review-and-meta-analysis-of-randomized-placebo-controlled-trials
#17
REVIEW
C Mazaud, L Fardet
Low-dose (i.e., ≤30 mg/week) methotrexate is widely prescribed by dermatologists. However, there are few evidence-based data regarding the relative risk of and determinants for adverse events associated with this treatment. The aims of this review were to assess the relative risk of and the determinants for adverse events associated with low-dose methotrexate exposure. A systematic review was undertaken using the MEDLINE, EMBASE, and CENTRAL databases. Randomized controlled trials comparing low-dose methotrexate with placebo were eligible...
February 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28179388/disseminated-intravascular-coagulation-like-reaction-following-rituximab-infusion
#18
Hind Rafei, Samah Nassereddine, Ivan F Garcia
Rituximab generally is a well-tolerated medication used in a variety of haematological and autoimmune conditions. The safety profile of the medication has been reviewed in the literature. Infusion reactions due to cytokine release are the most common side effects. With the increased use of rituximab, there is an increase incidence of cytopenias, most commonly thrombocytopenia and leucopenia. Coagulopathy is quite rare, reported previously in four cases in the literature. We highlighted the clinical course of a 39-year-old patient with precursor B-cell acute lymphoblastic leukaemia who was started on rituximab infusion...
February 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28168070/chronic-subdural-hematoma-associated-with-thrombocytopenia-in-a-patient-with-human-immunodeficiency-virus-infection-in-cameroon
#19
Clovis Nkoke, Engelbert Bain Luchuo, Denis Teuwafeu, Ines Nepetsoun, Cyrille Nkouonlack
Hematological abnormalities including thrombocytopenia are common in patients living with HIV infection. Patients with HIV infection related thrombocytopenia present generally with only minor bleeding problems. But cases of subdural hematoma are very rare. A 61-year-old female with a history of HIV infection of 9 years' duration presented with a 3-month history of generalized headache associated with visual blurring and anterograde amnesia. There was no history of trauma or fever. She was treated empirically for cerebral toxoplasmosis for 6 weeks without any improvement of the symptoms...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28167210/purinergic-enzymatic-activities-in-lymphocytes-and-cardiomyocytes-of-mice-acutely-infected-by-trypanosoma-cruzi-modulating-the-inflammatory-responses
#20
Guilherme M do Carmo, Pedro H Doleski, Mariângela F de Sá, Thirssa H Grando, Nathieli B Bottari, Daniela B R Leal, Lucas T Gressler, Luan C Henker, Ricardo E Mendes, Silvia G Monteiro, Aleksandro S Da Silva
The aim of this study was to evaluate the activity of purinergic enzymes in lymphocytes and cardiac tissue of mice experimentally infected by Trypanosoma cruzi. Twelve female mice were used, divided into two groups (n = 6): uninfected and infected. On day 12 post-infection (PI), the animals were anesthetized and after euthanized, and samples were collected for analyses. Infected mice showed reduction in erythrocyte counts, hematocrit and hemoglobin concentration, as well as reduced number of total leukocytes in consequence of neutrophilia (P < 0...
February 3, 2017: Experimental Parasitology
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