keyword
Keywords hemorrhagic transformation isc...

hemorrhagic transformation ischemic stroke

https://read.qxmd.com/read/38479035/predictive-model-for-the-risk-of-hemorrhagic-transformation-after-rt-pa-intravenous-thrombolysis-in-patients-with-acute-ischemic-stroke-a-systematic-review-and-meta-analysis
#1
REVIEW
Kelong Zhong, Xuemei An, Yun Kong, Zhu Chen
OBJECTIVE: To systematically review the risk prediction model of Hemorrhages Transformation (HT) after intravenous thrombolysis in patients with Acute Ischemic Stroke (AIS). METHODS: Web of Science, The Cochrane Library, PubMed, Embase, CINAHL, CNKI, CBM, WanFang, and VIP were searched from inception to February 25, 2023 for literature related to the risk prediction model for HT after thrombolysis in AIS. RESULTS: A total of 17 included studies contained 26 prediction models, and the AUC of all models at the time of modeling ranged from 0...
March 7, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38465591/intravenous-alteplase-versus-best-medical-therapy-for-patients-with-minor-stroke-a-systematic-review-and-meta-analysis
#2
JOURNAL ARTICLE
Yang Zhang, Tian Lv, Thanh N Nguyen, Simiao Wu, Zhi Li, Xue Bai, Dan Chen, Chuansheng Zhao, Wanyi Lin, Shiqin Chen, Yi Sui
BACKGROUND: The efficacy of thrombolysis (IVT) in minor stroke (National Institutes of Health Stroke Scale score, 0-5) remains inconclusive. The aim of this study is to compare the effectiveness and safety of IVT with best medical therapy (BMT) by means of a systematic review and meta-analysis of randomized controlled trials and observational studies. METHODS: We searched the PubMed, Embase, Cochrane Library, and Web of Science databases to obtain articles related to IVT in minor stroke from inception until August 10, 2023...
March 11, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38445153/hemorrhagic-transformation-in-patients-with-ischemic-stroke-and-atrial-fibrillation-to-anticoagulate-or-not-that-is-the-question
#3
Tiago Vasconcelos, Fábio Caleça Emidio, Frederico Silva, Joana Nascimento, Marta Duarte
The management of anticoagulation in patients with ischemic stroke and atrial fibrillation (AF) poses a critical dilemma due to the inherent risk of hemorrhagic transformation. This article presents the case of an 89-year-old male with AF and recurrent ischemic strokes, highlighting the complex challenge of deciding whether to initiate or withhold anticoagulation. After the initial ischemic stroke event, the patient started a direct oral anticoagulant. Subsequent imaging revealed hemorrhagic transformation, leading to the cessation of anticoagulation...
February 2024: Curēus
https://read.qxmd.com/read/38438491/elevation-of-astrocyte-derived-extracellular-vesicles-over-the-first-month-post-stroke-in-humans
#4
JOURNAL ARTICLE
Matthew A Edwardson, Masato Mitsuhashi, Dennis Van Epps
We sought to identify alterations in the quantity of plasma brain-derived extracellular vesicles (EV) over the first month post-stroke to shed light on related injury and repair mechanisms. We assessed plasma levels of presumed neuron-derived EVs (NDEs), astrocyte-derived EVs (ADEs), and oligodendrocyte-derived EVs (ODEs) in 58 patients 5, 15, and 30 days post-ischemic stroke and 46 controls matched for cardiovascular risk factors using sandwich immunoassays. Subsets of brain-derived EVs were identified by co-expression of the general EV marker CD9 and markers for neurons (L1CAM, CD171), astrocytes (EAAT1), and oligodendrocytes (MOG) respectively...
March 4, 2024: Scientific Reports
https://read.qxmd.com/read/38436292/pharmacological-preclinical-comparison-of-tenecteplase-and-alteplase-for-the-treatment-of-acute-stroke
#5
JOURNAL ARTICLE
Clara Correa-Paz, María Pérez-Mato, Mathys Bellemain-Sagnard, Marco González-Domínguez, Pauline Marie, Lara Pérez-Gayol, Esteban López-Arias, Lucia Del Pozo-Filíu, Sonia López-Amoedo, Ana Bugallo-Casal, María Luz Alonso-Alonso, María Candamo-Lourido, María Santamaría-Cadavid, Susana Arias-Rivas, Manuel Rodríguez-Yañez, Ramón Iglesias-Rey, José Castillo, Denis Vivien, Marina Rubio, Francisco Campos
Alteplase (rtPA) remains the standard thrombolytic drug for acute ischemic stroke. However, new rtPA-derived molecules, such as tenecteplase (TNK), with prolonged half-lives following a single bolus administration, have been developed. Although TNK is currently under clinical evaluation, the limited preclinical data highlight the need for additional studies to elucidate its benefits. The toxicities of rtPA and TNK were evaluated in endothelial cells, astrocytes, and neuronal cells. In addition, their in vivo efficacy was independently assessed at two research centers using an ischemic thromboembolic mouse model...
March 4, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38412858/leptomeningeal-collaterals-regulate-reperfusion-in-ischemic-stroke-and-rescue-the-brain-from-futile-recanalization
#6
JOURNAL ARTICLE
Nadine Felizitas Binder, Mohamad El Amki, Chaim Glück, William Middleham, Anna Maria Reuss, Adrien Bertolo, Patrick Thurner, Thomas Deffieux, Chryso Lambride, Robert Epp, Hannah-Lea Handelsmann, Philipp Baumgartner, Cyrille Orset, Philipp Bethge, Zsolt Kulcsar, Adriano Aguzzi, Mickael Tanter, Franca Schmid, Denis Vivien, Matthias Tasso Wyss, Andreas Luft, Michael Weller, Bruno Weber, Susanne Wegener
Recanalization is the mainstay of ischemic stroke treatment. However, even with timely clot removal, many stroke patients recover poorly. Leptomeningeal collaterals (LMCs) are pial anastomotic vessels with yet-unknown functions. We applied laser speckle imaging, ultrafast ultrasound, and two-photon microscopy in a thrombin-based mouse model of stroke and fibrinolytic treatment to show that LMCs maintain cerebral autoregulation and allow for gradual reperfusion, resulting in small infarcts. In mice with poor LMCs, distal arterial segments collapse, and deleterious hyperemia causes hemorrhage and mortality after recanalization...
February 16, 2024: Neuron
https://read.qxmd.com/read/38412839/late-lesion-growth-following-endovascular-therapy-is-24-hours-too-early-to-assess-acute-infarct-size-including-the-effects-of-secondary-injury
#7
JOURNAL ARTICLE
Marie Luby, Amie W Hsia, Carolyn A Lomahan, Victoria Uche, Rachel Davis, Yongwoo Kim, Sana Somani, Shannon Burton, Rainier Cabatbat, Veronica Craft, Jill B De Vis, Malik M Adil, Mariam M Afzal, Leila C Thomas, William Gandler, Evan S McCreedy, John K Lynch, Lawrence L Latour
Introduction Stroke lesion volume on MRI or CT provides objective evidence of tissue injury as a consequence of ischemic stroke. Measurement of "final" lesion volume at 24hr following endovascular therapy (post-EVT) has been used in multiple studies as a surrogate for clinical outcome. However, despite successful recanalization, a significant proportion of patients do not experience favorable clinical outcome. The goals of this study were to quantify lesion growth during the first week after treatment, identify early predictors, and explore the association with clinical outcome...
February 27, 2024: Cerebrovascular Diseases
https://read.qxmd.com/read/38410198/feasibility-and-comparability-of-different-platelet-function-tests-in-acute-stroke-with-or-without-prior-antiplatelet-therapy
#8
JOURNAL ARTICLE
Jan Hendrik Schaefer, Franziska Lieschke, Hans Urban, Ferdinand O Bohmann, Florian Gatzke, Wolfgang Miesbach
BACKGROUND: The clinical course of ischemic and hemorrhagic strokes can be influenced by the coagulation status of individual patients. The prior use of antiplatelet therapy (APT) such as acetylsalicylic acid (ASA) or P2Y12-antagonists has been inconsistently described as possibly increasing the risk of hemorrhagic transformation or expansion. Since clinical studies describing prior use of antiplatelet medication are overwhelmingly lacking specific functional tests, we aimed to implement testing in routine stroke care...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38404657/embolization-of-infective-endocarditis-vegetation-causes-intracranial-hemorrhage-with-hemorrhagic-transformation-after-ischemic-stroke
#9
Averina O Aslani, Zahran Haryawan, Tania A Sabrawi, Robin H Wibowo, Aprilianasary U Dewi
BACKGROUND: Infective endocarditis (IE) is a rare, but potentially fatal, infectious disease. One of the common complications of IE is the embolization of endocardial vegetation with subsequent intracerebral artery obstruction that causes acute ischemic stroke. Herein, we present a case report of a patient presenting with a neurological manifestation that turned out to be a complication of IE. CASE ILLUSTRATION: We present the case of a patient with a chief complaint of left-sided hemiplegia...
January 3, 2024: Global Cardiology Science & Practice
https://read.qxmd.com/read/38404630/the-catastrophic-association-of-prosthetic-mitral-valve-thrombosis-and-hemorrhagic-stroke
#10
Humberto Morais, Mauer A A Gonçalves
Prosthetic valve thrombosis is a serious complication of valve replacement associated with a high mortality rate. Stroke may be the first symptom of prosthetic valve thrombosis. We present the case of a patient who visited the emergency department with symptoms of dysarthria and left hemiparesis. An examination revealed an ischemic stroke with hemorrhagic transformation, stemming from a thrombosis of their mitral valve prosthesis, which progressed to the patient's death. We emphasize the difficulty in the therapeutic and diagnostic management of these patients...
September 30, 2023: Global Cardiology Science & Practice
https://read.qxmd.com/read/38395098/statin-treatment-in-stroke-patient-with-low-density-lipoprotein-cholesterol-levels-below-70-mg-dl
#11
JOURNAL ARTICLE
Kang-Po Lee, Hui-Chi Huang, Jui-Yao Tsai, Li-Chi Hsu
BACKGROUND AND PURPOSE: The effectiveness of hyperlipidemia treatment in strokes secondary prevention has been established. However, whether pretreatment with statins could confer protective effects when a patient's baseline low-density lipoprotein cholesterol (LDL-C) level is <70 mg/dL remains uncertain. Additionally, the ability of statin treatment to reduce poststroke complications, mortality, and recurrence in this patient group is unclear. METHODS AND RESULTS: In this retrospective observational study, we enrolled patients who had experienced an ischemic stroke with LDL-C levels <70 mg/dL...
February 21, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38393673/effect-of-continuous-2%C3%A2-mhz-transcranial-ultrasound-as-an-adjunct-to-tenecteplase-thrombolysis-in-acute-anterior-circulation-ischemic-stroke-patients-an-open-labeled-non-randomized-clinical-trial
#12
JOURNAL ARTICLE
Semparuthi Arumugham, Sunil K Narayan, Rajeswari Aghoram
The treatment of acute ischemic stroke has improved in last few decades. While meta-analyses of several trials have established the safety and efficacy of Intravenous (IV) Tenecteplase thrombolysis, concomitant continuous transcranial doppler (TCD) ultrasound administration has not been assessed in any clinical trial. The aim of this study was to determine the effects of continuous 2 MHz TCD ultrasound during IV Tenecteplase thrombolysis for Middle cerebral artery (MCA) stroke. A total of 19 patients were included, 13 received TCD ultrasound and 6 sham TCD with IV Tenecteplase...
February 23, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38392649/mechanical-thrombectomy-via-transbrachial-approach-in-the-emergency-management-of-acute-ischemic-stroke-patients-with-aortic-pathologies-our-experience-and-literature-review
#13
REVIEW
Aida Iancu, Raluca Tudor, Dana Simona Chita, Catalin Juratu, Anca Tudor, Florina Buleu, Daian Popa, Silviu Brad
STUDY DESIGN: Mechanical thrombectomy (MT) via the transbrachial approach (TBA) is a very rare option used in cases of patients with aortic pathologies and acute ischemic stroke (AIS) due to the insufficient evidence in the literature, the difficulty from a technical point of view and the result of this technique influenced by the complications that frequently accompany it. BACKGROUND: Only a few cases of patients with aortic pathologies and acute ischemic stroke where MT via TBA were reported in the literature, and its application in the emergency management of AIS has still not been dealt with in detail...
February 18, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38381145/use-of-the-preset-lite-thrombectomy-device-in-combined-approach-for-medium-vessel-occlusions-a-multicenter-evaluation
#14
JOURNAL ARTICLE
Maud Wang, Hans Henkes, Sherief Ghozy, James E Siegler, Hamza Shaikh, Jane Khalife, Mohamad Abdalkader, Piers Klein, Thanh N Nguyen, Jeremy J Heit, Ahmad Sweid, Kareem El Naamani, Robert W Regenhardt, Jose Danilo Bengzon Diestro, Nicole M Cancelliere, Abdelaziz Amllay, Lukas Meyer, Anne Dusart, Flavio Bellante, Géraud Forestier, Aymeric Rouchaud, Suzana Saleme, Charbel Mounayer, Jens Fiehler, Anna Luisa Kühn, Ajit S Puri, Christian Dyzmann, Peter T Kan, Marco Colasurdo, Gaultier Marnat, Jérôme Berge, Xavier Barreau, Igor Sibon, Simona Nedelcu, Nils Henninger, Charlotte Weyland, Thomas R Marotta, Christopher J Stapleton, James D Rabinov, Takahiro Ota, Shogo Dofuku, Leonard Ll Yeo, Benjamin Y Q Tan, Juan Carlos Martinez-Gutierrez, Sergio Salazar-Marioni, Sunil Sheth, Leonardo Renieri, Carolina Capirossi, Ashkan Mowla, Stavropoula I Tjoumakaris, Pascal Jabbour, Priyank Khandelwal, Arundhati Biswas, Frédéric Clarençon, Mahmoud Elhorany, Kevin Premat, Iacopo Valente, Alessandro Pedicelli, João Pedro Filipe, Ricardo Varela, Miguel Quintero-Consuegra, Nestor R Gonzalez, Markus A Möhlenbruch, Jessica Jesser, Vincent Costalat, Adrien Ter Schiphorst, Vivek Yedavalli, Pablo Harker, Lina M Chervak, Yasmin Aziz, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Monika Killer-Oberpfalzer, Christoph J Griessenauer, Ajith J Thomas, Cheng-Yang Hsieh, David S Liebeskind, Răzvan Alexandru Radu, Andrea M Alexandre, Illario Tancredi, Tobias D Faizy, Aman B Patel, Vitor Mendes Pereira, Robert Fahed, Boris Lubicz, Adam A Dmytriw, Adrien Guenego
PURPOSE: Our purpose was to assess the efficacy and safety of the pRESET LITE stent retriever (Phenox, Bochum, Germany), designed for medium vessel occlusion (MeVO) in acute ischemic stroke (AIS) patients with a primary MeVO. METHODS: We performed a retrospective analysis of the MAD MT Consortium, an integration of prospectively maintained databases at 37 academic institutions in Europe, North America, and Asia, of AIS patients who underwent mechanical thrombectomy with the pRESET LITE stent retriever for a primary MeVO...
February 21, 2024: Neuroradiology
https://read.qxmd.com/read/38373967/differential-expression-of-semaphorin-7a-cd163-positive-macrophages-in-large-artery-and-cardiogenic-stroke
#15
JOURNAL ARTICLE
Yi Jiang, Zhichao Sun, Zhonglin Ge, Zhonghai Tao, Mengqian Liu, Wen Zhong, Nan Dong, Lei Xu, Hui Wang, Yiwen Xu, Xiaozhu Shen
BACKGROUND: Identification of the causes of stroke of undetermined etiology, specifically cardioembolism (CE) and non-CE causes, can inform treatment planning and prognosis prediction. The objective of this study was to analyze the disparities in thrombus composition, particularly Semaphorin-7A (Sema7A) and CD163, between patients diagnosed with large-artery atherosclerosis (LAA) and those with CE, and to investigate their potential association with prognosis. METHODS: Thrombi were collected from patients who underwent mechanical thrombectomy at two hospitals...
February 19, 2024: BMC Neurology
https://read.qxmd.com/read/38361636/the-value-of-ct-based-radiomics-in-predicting-hemorrhagic-transformation-in-acute-ischemic-stroke-patients-without-recanalization-therapy
#16
JOURNAL ARTICLE
Yin-Hui Huang, Zhen-Jie Chen, Ya-Fang Chen, Chi Cai, You-Yu Lin, Zhi-Qiang Lin, Chun-Nuan Chen, Mei-Li Yang, Yuan-Zhe Li, Yi Wang
OBJECTIVE: The aim of this study is to investigate the clinical value of radiomics based on non-enhanced head CT in the prediction of hemorrhage transformation in acute ischemic stroke (AIS). MATERIALS AND METHODS: A total of 140 patients diagnosed with AIS from January 2015 to August 2022 were enrolled. Radiomic features from infarcted areas on non-enhanced CT images were extracted using ITK-SNAP. The max-relevance and min-redundancy (mRMR) and the least absolute shrinkage and selection operator (LASSO) were used to select features...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38355868/cerebral-microbleeds-and-risk-of-symptomatic-hemorrhagic-transformation-following-mechanical-thrombectomy-for-large-vessel-ischemic-stroke
#17
JOURNAL ARTICLE
Rémi Agbonon, Géraud Forestier, Nicolas Bricout, Wagih Benhassen, Guillaume Turc, Martin Bretzner, Marco Pasi, Joseph Benzakoun, Pierre Seners, Imad Derraz, Laurence Legrand, Denis Trystram, Christine Rodriguez-Regent, Andreas Charidimou, Natalia S Rost, Serge Bracard, Charlotte Cordonnier, Omer F Eker, Catherine Oppenheim, Olivier Naggara, Hilde Henon, Grégoire Boulouis
BACKGROUND AND PURPOSE: In patients with acute ischemic stroke (AIS) treated with endovascular therapy (EVT), the association of pre-existing cerebral small vessel disease (cSVD) with symptomatic intracerebral hemorrhage (sICH) remains controversial. We tested the hypothesis that the presence of cerebral microbleeds (CMBs) and their burden would be associated with sICH after EVT of AIS. METHODS: We conducted a retrospective study combining cohorts of patients that underwent EVT between January 1st 2015 and January 1st 2020...
February 14, 2024: Journal of Neurology
https://read.qxmd.com/read/38344578/spontaneous-intracranial-hemorrhages-in-a-community-of-asian-americans-case-series-and-literature-review
#18
JOURNAL ARTICLE
Henry Querfurth, Izabella Marczak, Nasrin Rahimian, Amir Jijakli, Deborah Green-LaRoche
Background and objectives Several Asian populations abroad are reported to have a higher prevalence of spontaneous intracranial hemorrhages (sICH) and a greater proportion of all stroke types attributed to ICH compared to non-Asians. However, the causes are unknown, and few studies have examined the issue among Asian Americans. This report aims to highlight some less common, but not rare, clinical features that could bear on several pathophysiological factors, by presenting a selected case series of 13 Asian American patients admitted to a Boston-based healthcare system and hospital...
January 2024: Curēus
https://read.qxmd.com/read/38343709/early-apixaban-administration-considering-the-size-of-infarction-and-functional-outcome-in-acute-ischemic-stroke
#19
JOURNAL ARTICLE
Min Hwan Lee, Jaseong Koo, Hanim Kwon, Jun Young Chang, Dong-Wha Kang, Sun U Kwon, Jong S Kim, Bum Joon Kim
BACKGROUND AND PURPOSE: Atrial fibrillation-related stroke (AF-stroke) is associated with an adverse prognosis, characterized by a high incidence of progression, recurrence, and hemorrhagic transformation. Our study aims to investigate the potential benefits of stratified early administration of apixaban, taking into account infarct size during the acute phase, in order to enhance functional outcomes. METHODS: We conducted this study at a tertiary referral stroke center, enrolling acute AF-stroke patients who received apixaban during the acute phase...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38326704/update-of-anticoagulation-use-in-cardioembolic-stroke-with-a-special-reference-to-endovascular-treatment
#20
REVIEW
Apostolos Safouris, Klearchos Psychogios, Lina Palaiodimou, Peter Orosz, George Magoufis, Odysseas Kargiotis, Aikaterini Theodorou, Theodore Karapanayiotides, Stavros Spiliopoulos, Sándor Nardai, Amrou Sarraj, Thanh N Nguyen, Shadi Yaghi, Silke Walter, Simona Sacco, Guillaume Turc, Georgios Tsivgoulis
Cardioembolic stroke is a major cause of morbidity, with a high risk of recurrence, and anticoagulation represents the mainstay of secondary stroke prevention in most patients. The implementation of endovascular treatment in routine clinical practice complicates the decision to initiate anticoagulation, especially in patients with early hemorrhagic transformation who are considered at higher risk of hematoma expansion. Late hemorrhagic transformation in the days and weeks following stroke remains a potentially serious complication for which we still do not have any established clinical or radiological prediction tools...
January 2024: Journal of Stroke
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