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https://www.readbyqxmd.com/read/29345380/cirp-increases-icam-1-phenotype-of-neutrophils-exhibiting-elevated-inos-and-nets-in-sepsis
#1
Yasumasa Ode, Monowar Aziz, Ping Wang
Sepsis represents uncontrolled inflammation due to an infection. Cold-inducible RNA-binding protein (CIRP) is a stress-induced damage-associated molecular pattern (DAMP). A subset of neutrophils expressing ICAM-1+ neutrophils was previously shown to produce high levels of reactive oxygen species. The role of CIRP for the development and function of ICAM-1+ neutrophils during sepsis is unknown. We hypothesize that CIRP induces ICAM-1 expression in neutrophils causing injury to the lungs during sepsis. Using a mouse model of cecal ligation and puncture (CLP)-induced sepsis, we found increased expression of CIRP and higher frequencies and numbers of ICAM-1+ neutrophils in the lungs...
January 17, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29345067/supramolecular-gels-derived-from-the-salts-of-variously-substituted-phenylacetic-acid-and-dicyclohexyl-amine-design-synthesis-structures-and-dye-adsorption
#2
Parthasarathi Dastidar, Rajdip Roy, Tapas Kumar Adalder
A well-studied supramolecular synthon namely secondary ammonium monocarboxylate (SAM) was exploited to generate a new series of organic salts derived from variously substituted phenylacetic acid (PA) and dicyclohexyl amine (DCA) as potential low molecular weight gelators (LMWGs). As much as 25% of the SAM salts under study were gelators. The gels were characterized by rheology and the morphology of the gel networks was studied by high resolution electron microscopy. Single crystal and powder X-ray diffraction data were employed to study structure-property (gelation) correlation...
January 18, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29344353/effects-of-tnf-receptor-blockade-on-in-vitro-cell-survival-and-response-to-negative-energy-balance-in-dairy-cattle
#3
C A Martel, L K Mamedova, J E Minton, M Garcia, C Legallet, B J Bradford
Background: Associative data and some controlled studies suggest that the inflammatory cytokine tumor necrosis factor (TNF) α can induce fatty liver in dairy cattle. However, research demonstrating that TNFα is a necessary component in the etiology of bovine fatty liver is lacking. The aim of this work was to evaluate whether blocking TNFα signaling with a synthetic cyclic peptide (TNF receptor loop peptide; TRLP) would improve liver metabolic function and reduce triglyceride accumulation during feed restriction...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29340644/proteasome-inhibition-increases-the-efficiency-of-lentiviral-vector-mediated-transduction-of-trabecular-meshwork
#4
Zeynep Aktas, Hongyu Rao, Sarah R Slauson, B'Ann T Gabelt, Inna V Larsen, Rachael T C Sheridan, Leonie Herrnberger, Ernst R Tamm, Paul L Kaufman, Curtis R Brandt
Purpose: To determine if proteasome inhibition using MG132 increased the efficiency of FIV vector-mediated transduction in human trabecular meshwork (TM)-1 cells and monkey organ-cultured anterior segments (MOCAS). Methods: TM-1 cells were pretreated for 1 hour with 0.5% dimethyl sulfoxide (DMSO; vehicle control) or 5 to 50 μM MG132 and transduced with FIV.GFP (green fluorescent protein)- or FIV.mCherry-expressing vector at a multiplicity of transduction (MOT) of 20...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29339227/a-novel-biphenolic-ligand-for-selective-mg2-and-zn2-ions-sensing-followed-by-colorimetric-spectroscopic-and-cell-imaging-methods
#5
Palanisamy Uma Maheswari, Duraisamy Renuga, H L Jeeva Kumari, Kandasamy Ruckmani
The (E)-2-((2-hydrohy-5-methylphenylimino) methyl) phenol ligand was synthesized. The receptor was characterized by IR, 1H and 13C NMR and CHN analysis. The ligand exhibits colorimetric and fluorometric sensing of Zn2+ and Mg2+ ions in semi-aqueous medium (DMSO-H2O). The receptor was tested with series of transition metal ions (Cr2+, Fe2+, Ni2+, Co2+, Cu2+, Zn2+) and heavy metal ions (Sn2+, Pd2+, Ce2+, Hg2+, Cd2+) and the essential human body elements like Ca2+, Mg2+, Na+ and K+ ions. The naked eye colorimetric sensing was absorbed only for Zn2+ and Mg2+...
January 12, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29337098/synthesis-and-characterization-of-chitin-curcumin-blended-polyurethane-elastomers
#6
Kashif Mahmood, Khalid Mahmood Zia, Waseem Aftab, Mohammad Zuber, Shazia Tabasum, Aqdas Noreen, Fatima Zia
In this work, chitin-curcumin based polyurethane elastomers (PUEs) were prepared by step growth polymerization technique using hydroxy terminated polybutadiene (HTPB), hexamethylene diisocyanate (HDI), chitin and curcumin. The molecular characterization was done by using FTIR and SS 1HNMR techniques. The surface morphology and thermal stability was studied by scanning electron microscopy (SEM) and thermal gravimetric analysis (TGA), respectively. Degree of absorption and swelling characters were also determined in water as well as in DMSO...
January 11, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29336561/a-borane-platinum-complex-undergoing-reversible-hydride-migration-in-solution
#7
Abdollah Neshat, Hamid R Shahsavari, Piero Mastrorilli, Stefano Todisco, Mohsen Golbon Haghighi, Behrouz Notash
Reaction of [Pt(κ2-C,N-ppy)(dmso)Cl], 1 (Hppy = 2-phenylpyridine), with Na[H2B(mb)2] (Hmb = 2-mercapto-benzimidazole) smoothly afforded the complex {[(κ3-S,B,S-HB(mb)2]Pt(κ2-C,N-ppy)H}, 2, featuring a strong reverse-dative Pt → B σ interaction in the solid state. When dissolved in thf (or acetone) solution, 2 undergoes a reversible Pt-H bond activation, establishing an equilibrium between the hexacoordinated 2 and the tetracoordinate complex {[(κ2-S,S-H2B(mb)2]Pt(κ2-C,N-ppy)}, 3, as ascertained by multinuclear NMR...
January 16, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29335202/5-bromo-oxoisoaporphine-platinum-ii-complexes-exhibit-tumor-cell-cytotoxcicity-via-inhibition-of-telomerase-activity-and-disruption-of-c-myc-g-quadruplex-dna-and-mitochondrial-functions
#8
Zu-Zhuang Wei, Qi-Pin Qin, Ting Meng, Cai-Xing Deng, Hong Liang, Zhen-Feng Chen
Two platinum(II) complexes [Pt(L)(DMSO)Cl] (1) and [Pt(L)(pn)]Cl (2) with 5-bromo-oxoisoaporphine (H-L) were synthesized. We found that the two new platinum(II) complexes were more selective for Hep-G2 tumor cells than for normal cells (HL-7702, WI-38 and L-o2 cell lines). 5-Bromine-oxoisoaporphine platinum(II) complex 2 was a telomerase inhibitor targeting c-myc G4, and it triggered Hep-G2 cell apoptosis more potently than complex 1. Moreover, they induced cell apoptosis via disruption of mitochondrial functions...
January 4, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29334455/modulating-the-molybdenum-coordination-sphere-of-escherichia-coli-trimethylamine-n-oxide-reductase
#9
Paul Kaufmann, Benjamin R Duffus, Biljana Mitrova, Chantal Iobbi-Nivol, Christian Teutloff, Manfred Nimtz, Lothar Jänsch, Ulla Wollenberger, Silke Leimkühler
The well-studied enterobacterium Escherichia coli present in the human gut is able to reduce TMAO to trimethylamine (TMA) during anaerobic respiration. The TMAO reductase TorA is a monomeric, bis-molybdopterin guanine dinucleotide (bis-MGD) cofactor-containing enzyme belonging to the dimethylsulfoxide (DMSO) reductase family of molybdoenzymes. We report on a system for the in vitro reconstitution of TorA with molybdenum cofactors (Moco) from different sources. Higher TMAO reductase activities for TorA were obtained when using Moco-sources containing a sulfido ligand at the molybdenum atom...
January 15, 2018: Biochemistry
https://www.readbyqxmd.com/read/29333740/pharmacokinetics-disposition-and-plasma-concentrations-of-dimethyl-sulfoxide-dmso-in-the-horse-following-topical-oral-and-intravenous-administration
#10
L R Soma, M A Robinson, Y You, R C Boston, J Rudy
Compartmental models were used to investigate the pharmacokinetics of intravenous (i.v.), oral (p.o.), and topical (TOP) administration of dimethyl sulfoxide (DMSO). The plasma concentration-time curve following a 15-min i.v. infusion of DMSO was described by a two-compartment model. Median and range of alpha (t1/2α ) and beta (t1/2β ) half-lives were 0.029 (0.026-0.093) and 14.1 (6.6-16.4) hr, respectively. Plasma concentration-time curves of DMSO following p.o. and TOP administration were best described by one-compartment absorption and elimination models...
January 14, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29333049/marine-derived-fungi-extracts-enhance-the-cytotoxic-activity-of-doxorubicin-in-nonsmall-cell-lung-cancer-cells-a459
#11
Bruno Castro-Carvalho, Alice A Ramos, Maria Prata-Sena, Fernanda Malhão, Márcia Moreira, Daniela Gargiulo, Tida Dethoup, Suradet Buttachon, Anake Kijjoa, Eduardo Rocha
Background: Drug resistance is a major concern in the current chemotherapeutic approaches and the combination with natural compounds may enhance the cytotoxic effects of the anticancer drugs. Therefore, this study evaluated the cytotoxicity of crude ethyl extracts of six marine-derived fungi - Neosartorya tsunodae KUFC 9213 (E1), Neosartorya laciniosa KUFC 7896 (E2), Neosartorya fischeri KUFC 6344 (E3), Aspergillus similanensis KUFA 0013 (E4), Neosartorya paulistensis KUFC 7894 (E5), and Talaromyces trachyspermum KUFC 0021 (E6) - when combined with doxorubicin (Dox), in seven human cancer cell lines...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29330877/characterization-of-biologic-response-modifiers-in-the-supernatant-of-conventional-refrigerated-and-cryopreserved-platelets
#12
Lacey Johnson, Shereen Tan, Emily Jenkins, Ben Wood, Denese C Marks
BACKGROUND: Alternatives to room temperature storage of platelets (PLTs) are of interest to support blood banking logistics. The aim of this study was to compare the presence of biologic response modifiers (BRMs) in PLT concentrates stored under conventional room temperature conditions with refrigerated or cryopreserved PLTs. STUDY DESIGN AND METHODS: A three-arm pool-and-split study was carried out using buffy coat-derived PLTs stored in 30% plasma/70% SSP+. The three matched treatment arms were as follows: room temperature (20-24°C), cold (2-6°C), and cryopreserved (-80°C with DMSO)...
January 12, 2018: Transfusion
https://www.readbyqxmd.com/read/29328378/liposome%C3%A2-delivered-baicalein-induction-of-myeloid-leukemia-k562-cell-death-via-reactive-oxygen-species-generation
#13
Scarlet Xiaoyan Wang, Xuesong Wen, Celia Bell, Sandra Appiah
Baicalein (BL), a potential cancer chemopreventative flavone, has been reported to inhibit cancer cell growth by inducing apoptosis and causing cell cycle arrest in various human cancer cell models. Delivery of BL via nanoliposomes has been shown to improve its oral bioavailability and long‑circulating property in vivo. However, the role of BL in the inhibition of human chronic myeloid leukemia (CML) K562 cell growth and its underlying mechanisms has yet to be elucidated. In the present study, BL was formulated into liposomes with different sizes to improve its solubility and stability...
January 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29325386/-the-protective-effect-of-the-activation-of-nmdar1-erk1-2-signal-pathway-induced-by-levodopa-on-visual-cortical-neurons-in-monocular-deprivation-rats
#14
X N Sun, H L Wang, G Qiao, J Tao, C Liu, X H Hao
Objective: To investigate the protection effects of the activation of NMDAR1(NMDA receptor 1)/ERK1/2 signal pathway on visual cortex nerve cells induced by levodopa in amblyopia rats. Methods: SD rats of SPF grade, were randomly divided into for groups of 9, group A. Control, B. MD group, C. L-levodopa(20 mg·kg(-1))+MD group, D. H-levodopa (80 mg·kg(-1))+MD group, E. H-levodopa+MD+MK801 group, F. H-levodopa+MD+PD98059 group, G. MD+MK801 group, H. MD+PD98059 group, I. MD+DMSO group. Amblyopia rats were made by suture of the right eye...
December 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29323496/direct-synthesis-of-quinolines-via-co-iii-catalyzed-and-dmso-involved-c-h-activation-cyclization-of-anilines-with-alkynes
#15
Xuefeng Xu, Yurong Yang, Xu Zhang, Wei Yi
A unique Co(III)-catalyzed and DMSO-involved C-H activation/cyclization of simple, cheap, and easily available anilines with alkynes for direct and highly efficient synthesis of privileged quinolines with exclusive regioselectivity and broad substrate/functional group tolerance and in good to excellent yields, where DMSO was employed as both the solvent and the C1 building block of quinoline products, is reported. Mechanistic experiments revealed that the versatile reaction might employ the 2-vinylbenzenamine species as the active intermediate...
January 11, 2018: Organic Letters
https://www.readbyqxmd.com/read/29321035/dhea-induced-ovarian-hyperfibrosis-is-mediated-by-tgf-%C3%AE-signaling-pathway
#16
Daojuan Wang, Wenqing Wang, Qiao Liang, Xuan He, Yanjie Xia, Shanmei Shen, Hongwei Wang, Qian Gao, Yong Wang
BACKGROUND: The polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disorder with pathological mechanisms remain unclear. The following study investigates the ovarian hyperfibrosis forming via transforming growth factor-β (TGF-β) signaling pathway in Dehydroepiandrosterone (DHEA)- induced polycystic ovary syndrome (PCOS) rat model. We furthermore explored whether TGF-βRI inhibitor (SB431542) decreases ovarian fibrosis by counterbalancing the expression of fibrotic biomarkers...
January 10, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29318318/synthesis-and-x-ray-structural-analysis-of-the-ruthenium-iii-complex-na-trans-rucl4-dmso-pyrdiaz-the-diazene-derivative-of-antitumor-nami-pyr
#17
Jure Vajs, Andrej Pevec, Martin Gazvoda, Damijana Urankar, Evgeny Goreshnik, Slovenko Polanc, Janez Košmrlj
Novel tetrachloridoruthenium(III) complex Na[trans-RuCl4(DMSO)(PyrDiaz)] (3) with pyridine-tethered diazenedicarboxamide PyrDiaz ligand (PyrDiaz = N1-(4-isopropylphenyl)-N2-(pyridin-2-ylmethyl)diazene-1,2-dicarboxamide) was synthesized by direct coupling of PyrDiaz with sodium trans-bis(dimethyl sulfoxide)tetrachloridoruthenate(III) (Na-[trans-Ru(DMSO)2Cl4]). Compound 3 is the analogue of the antimetastatic Ru(III) complex NAMI-A and NAMI-Pyr. Single crystal X.
December 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/29317328/investigation-of-in-vitro-genotoxic-effects-of-an-anti-diabetic-drug-sitagliptin
#18
Deniz Yuzbasioglu, Cemile Enguzel-Alperen, Fatma Unal
Sitagliptin is an active ingredient of antidiabetic drug used in the treatment of type 2 diabetes mellitus (T2DM). In this study, the genotoxic effects of sitagliptin were determined in human lymphocytes by using chromosome aberrations (CAs), sister chromatid exchanges (SCEs), micronucleus (MN) and comet assays. 31.25-1000 μg/mL concentrations of sitagliptin were used. Sitagliptin significantly increased the frequency of CAs and SCEs at the highest concentration at 24 h treatment and all concentrations (except 250 μg/mL for CA, except 31...
January 6, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29316692/3-3-diindolylmethane-suppressed-cyprodinil-induced-epithelial-mesenchymal-transition-and-metastatic-related-behaviors-of-human-endometrial-ishikawa-cells-via-an-estrogen-receptor-dependent-pathway
#19
Bo-Gyoung Kim, Jin-Wook Kim, Soo-Min Kim, Ryeo-Eun Go, Kyung-A Hwang, Kyung-Chul Choi
Cyprodinil (CYP) is a pyrimidine amine fungicide that has been extensively used in agricultural areas. 3,3'-Diindolylmethane (DIM) is a derivative of the dietary phytoestrogen, indole-3-carbinol (I3C), which is derived from cruciferous vegetables and considered to be a cancer-preventive phytonutrient agent. In this study, the effects of CYP and DIM were examined on the cell viability, invasion, and metastasis of human endometrial cancer cells, Ishikawa, via epithelial mesenchymal transition (EMT). CYP increased the level of cell viability of Ishikawa cells compared to DMSO as a control, as did E2...
January 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29316332/formation-of-fluorinated-amido-esters-through-unexpected-c3-c4-bond-fission-in-4-trifluoromethyl-3-oxo-%C3%AE-lactams
#20
Hang Dao Thi, Hannelore Goossens, Dietmar Hertsen, Valerie Otte, Tuyen Van Nguyen, Veronique Van Speybroeck, Matthias D'hooghe
4-Trifluoromethyl-3-oxo-β-lactams were unexpectedly transformed into 2-[(2,2-difluorovinyl)amino]-2-oxoacetates as major products, accompanied by minor amounts of 2-oxo-2-[(2,2,2-trifluoroethyl)amino]acetates, upon treatment with alkyl halides and triethylamine in DMSO. This peculiar C3-C4 bond fission reactivity was investigated in-depth, from both an experimental and a computational point of view, in order to shed light on the underlying reaction mechanism.
January 9, 2018: Chemistry, An Asian Journal
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