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https://www.readbyqxmd.com/read/28340290/nucleus-accumbens-dopamine-receptors-mediate-hypothalamus-induced-antinociception-in-the-rat-formalin-test
#1
A Siahposht-Khachaki, P Pourreza, S Ezzatpanah, A Haghparast
BACKGROUND: Lateral hypothalamus (LH) involves in modulation of tonic pain. Regarding the direct and indirect neural connections between the LH and nucleus accumbens (NAc), we aimed to examine the pain modulatory role of NAc dopamine receptors in modulation of LH-induced analgesia in the formalin test. METHODS: Vehicle-control groups received saline or DMSO into the NAc and saline into the LH. Carbachol-control groups received carbachol (250 nmol/L) into the LH, 5 min after saline or DMSO injection into the NAc...
March 24, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28339052/ahr%C3%A2-e2f1%C3%A2-kgfr-signaling-is-involved-in-kgf%C3%A2-induced-intestinal-epithelial-cell-proliferation
#2
Kunqiu Yang, Jiuheng Yin, Baifa Sheng, Qimeng Wang, Bin Han, Aimin Pu, Min Yu, Lihua Sun, Weidong Xiao, Hua Yang
Keratinocyte growth factor (KGF) stimulates intestinal epithelial cell proliferation upon binding to the KGF receptor (KGFR). The activated aryl hydrocarbon receptor (AhR) serves an important role in the development of tissues by promoting the expression of AhR receptors, which can regulate cell proliferation. In the present study, the signaling pathway between AhR and KGFR in investigated with regards to KGF‑induced intestinal epithelial cell proliferation. Male C57BL/6J wild type and AhR‑/‑ mice, were randomized into four groups: Control, KGF, AhR‑/‑ + KGF and AhR‑/‑ (n=6 per group)...
March 23, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28337793/solvent-regulated-self-assembly-of-achiral-donor-acceptor-complex-in-confined-chiral-nanotubes-chirality-transfer-inversion-and-amplification
#3
Yuangang Li, Pengfei Duan, Minghua Liu
A chiral gelator was designed and found to form chiral nanotwist and nanotube in toluene and DMSO, respectively, which could serve as host chiral matrixes for fabricating functional soft materials. Guest achiral π-conjugated donor and acceptor were doped in the gel and a solvent regulated self-assembly was observed. Although both the DMSO and toluene gels containing three components look similar as the transparent gels, it was clarified microscopically that while achiral dopants self-assembled in the confined nanotubes in DMSO gel, they only dissolve in the liquid phase in toluene gel...
March 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28337778/biochemical-alterations-in-duckweed-and-algae-induced-by-carrier-solvents-selection-of-an-appropriate-solvent-in-toxicity-testing
#4
Li-Xin Hu, Fei Tian, Francis L Martin, Guang-Guo Ying
Carrier solvents are often used in aquatic toxicity testing for test chemicals with hydrophobic properties. However, the knowledge of solvent effects on test organisms remains limited. This study aimed to understand biochemical effects of the four common solvents ((methanol, ethanol, acetone and dimethylsulfoxide (DMSO)) on two test species Lemna minor and Raphidocelis subcapitata by applying Fourier transform infrared spectroscopy (FTIR) coupled with multivariate analysis in order to select appropriate solvents in the toxicity testing...
March 24, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28337763/automatic-washing-of-thawed-haematopoietic-progenitor-cell-grafts-a-preclinical-evaluation
#5
M Abonnenc, B Pesse, J-D Tissot, S Barelli, N Lion
BACKGROUND AND OBJECTIVES: Autologous haematopoietic progenitor cell (HPC) is a prerequisite for high-dose chemotherapy in treatment of several haematologic and non-haematologic malignancies. HPCs are collected by apheresis and cryopreserved until infusion. Postinfusion adverse events have been in part related to the dimethyl sulphoxide (DMSO) used as cryoprotectant. The aim was to evaluate (i) an automated sequential washing procedure for DMSO removal in thawed HPC grafts and (ii) washing solutions in replacement of hydroxyethyl starch (HES)-based solutions...
March 23, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28336408/synthesis-properties-antitumor-and-antibacterial-activity-of-new-pt-ii-and-pd-ii-complexes-with-2-2-dithiobis-benzothiazole-ligand
#6
Simona Rubino, Rosalia Busà, Alessandro Attanzio, Rosa Alduina, Vita Di Stefano, Maria Assunta Girasolo, Santino Orecchio, Luisa Tesoriere
Mono- and binuclear Pt(II) and Pd(II) complexes with 2,2'-dithiobis(benzothiazole) (DTBTA) ligand are reported. [Pt(DTBTA)(DMSO)Cl]Cl∙CHCl3 (1) and [Pd2(µ-Cl)2(DTBTA)2]Cl2 (2) have been synthesized and structurally characterized by elemental analysis, IR, (1)H and (13)C NMR spectroscopy, MS spectrometry and the content of platinum and palladium was determined using a flame atomic spectrometer. Two different coordination modes of 1 and 2 complexes were found; in both complexes, the coordination of Pt(II) and Pd(II) ions involves the N(3) atoms of the ligand but the binuclear complex 2, is a cis-chloro-bridged palladium complex...
March 9, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28332839/cui-mediated-one-pot-cycloacetalization-ketalization-of-o-carbonyl-allylbenzenes-synthesis-of-benzobicyclo-3-2-1-octane-core
#7
Chieh-Kai Chan, Yu-Lin Tsai, Meng-Yang Chang
CuI/DMSO-mediated intramolecular cycloacetalization/ketalization of o-carbonyl allylbenzenes has been achieved for constructing [6,6,5]-tricycles having a ketal motif in good yields. The expeditious one-step route provides a three C-O bond formation. The key products with the structural framework of a benzofused dioxabicyclo[3.2.1]octane core have been confirmed by X-ray crystallographic analysis. Synthesis of dihydroisocoumarin has been studied.
March 23, 2017: Organic Letters
https://www.readbyqxmd.com/read/28332677/tuneable-reversible-redox-of-cobalt-iii-carbazole-complexes
#8
Michael S Bennington, Humphrey L C Feltham, Zoë J Buxton, Nicholas G White, Sally Brooker
Four tridentate carbazole-based ligands, HL((t)Bu/H) {3,6-di(tert-butyl)-1,8-bis[5-(3-benzyl-1,2,3-triazole)]-9H-carbazole}, HL((t)Bu/(t)Bu) {3,6-di(tert-butyl)-1,8-bis[5-(3-(4-tert-butyl)benzyl-1,2,3-triazole)]-9H-carbazole}, HL(H/H) {1,8-bis[5-(3-benzyl-1,2,3-triazole)]-9H-carbazole} and HL(H/(t)Bu) {1,8-bis[5-(3-(4-tert-butyl)benzyl-1,2,3-triazole)]-9H-carbazole}, were prepared and complexed with cobalt(ii) tetrafluoroborate. In situ air oxidation resulted in cobalt(iii) complexes 1-4 with the general formula [Co(III)(L)2]BF4·xH2O (1: L = L((t)Bu/H), x = 2; 2: L = L((t)Bu/(t)Bu), x = 1; 3: L = L(H/H), x = 0...
March 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28330425/taxane-derived-compounds-protect-sk-n-sh-cells-against-oxidative-stress-injury-induced-by-h2o2
#9
Ruisheng Duan, Xing Xing, Yachao Qi, Nan Yin, Hongyu Hao, Hongshan Chu, Ya Gao, Weiping Wang, Peiyuan Lv
OBJECTIVE: Discussed the protection of taxane-derived compounds, 7-deacetyl-taxine B and 5-cinnamoyloxy-taxin B, against oxidative stress injury. METHODS: SK-N-SH cells were pretreated with 7-deacetyl-taxine B, 5-cinnamoyloxy-taxin B or DMSO (control) and then incubated with H2O2 for another 24 h. Cell viability was measured by MTT colorimetric assay. Apoptosis rate, reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) were detected using flow cytometry assay...
March 22, 2017: Neurological Research
https://www.readbyqxmd.com/read/28330255/ascorbyl-palmitate-synthesis-in-an-organic-solvent-system-using-a-celite-immobilized-commercial-lipase-lipolase-100l
#10
Shivika Sharma, Kriti Kanwar, Shamsher S Kanwar
Ascorbyl palmitate was synthesized using a Celite-immobilized commercial lipase (Lipolase 100L) in dimethylsulfoxide (DMSO) as an organic solvent system. Lipase immobilized by surface adsorption onto Celite 545 matrix and subsequently exposed to 1 % glutaraldehyde showed 75 % binding of protein. The Celite-bound lipase was optimally active at 75 °C and pH 8.5 under shaking and showed maximum hydrolytic activity toward p-NPP as a substrate. The bound lipase was found to be stimulated only in the presence of Al(3+) and EDTA...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28328227/ultrafast-relaxation-dynamics-of-photoexcited-heme-model-compounds-observation-of-multiple-electronic-spin-states-and-vibrational-cooling
#11
Chinju Govind, Venugopal Karunakaran
Hemin is a unique model compound of heme proteins carrying out variable biological functions. Here the excited state relaxation dynamics of heme model compounds in the ferric form are systematically investigated by changing the axial ligand (Cl/Br), the peripheral substituent (Vinyl/Ethylmeso) and the solvent (Methanol/DMSO) using femtosecond pump-probe spectroscopy upon excitation at 380 nm. The relaxation time constants of these model compounds are obtained by global analysis. Excited state deactivation pathway of the model compounds comprising the decay of the porphyrin excited state (S*) to Ligand to Metal Charge Transfer state (LMCT, t1), back electron transfer from Metal to Ligand (MLCT, t2) and relaxation to the ground state through different electronic spin states of iron (t3 and t4), is proposed along with the vibrational cooling processes...
March 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28327767/regioselective-sn2-reactions-for-rapid-syntheses-of-azido-inositols-by-one-pot-sequence-specific-nucleophilysis
#12
Arthi Ravi, Syed Zahid Hassan, Ajithkumar N Vanikrishna, Kana M Sureshan
Triflates of myo-inositol undergo facile solvolysis in DMSO and DMF yielding SN2 products substituted with O-nucleophiles; DMF showed slower kinetics. Axial O-triflate undergoes faster substitution than equatorial O-triflate. By exploiting this difference in kinetics, solvent-tuning and sequence-controlled nucleophilysis, rapid synthesis of three azido-inositols of myo-configuration from myo-inositol itself has been achieved.
March 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28327766/phosphorescent-platinum-ii-alkynyls-end-capped-with-benzothiazole-units
#13
Rebeca Lara, Elena Lalinde, M Teresa Moreno
Symmetric trans-bis(alkynyl)bis(phosphine) Pt(II) complexes based on the 2-phenylbenzothiazole (pbt) unit [trans-Pt(C[triple bond, length as m-dash]C-pbt)2L2] [L = PPh31, PEt32, 1,3,5-triaza-7-phosphaadamantane (PTA) 3] and the mixed alkynyl-cyanide anionic complex (NBu4)2[trans-Pt(C[triple bond, length as m-dash]C-pbt)2(CN)2] (4) were synthesized. The complexes have been fully characterized including X-ray crystallography for 2 and 4. All complexes display long-lived emission with moderate quantum yields (ϕ 6...
March 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28327301/dentin-bond-optimization-using-the-dimethyl-sulfoxide-wet-bonding-strategy-a-2-year-in-vitro-study
#14
Thiago Henrique Scarabello Stape, Leo Tjäderhane, Arzu Tezvergil-Mutluay, Cristiane Rumi Fujiwara Yanikian, Anna Luiza Szesz, Alessandro Dourado Loguercio, Luís Roberto Marcondes Martins
OBJECTIVE: This study evaluated a new approach, named dimethyl sulfoxide (DMSO)-wet bonding, to produce more desirable long-term prospects for the ultrafine interactions between synthetic polymeric biomaterials and the inherently hydrated dentin substrate. METHODS: Sound third molars were randomly restored with/without DMSO pretreatment using a total-etch (Scocthbond Multipurpose: SBMP) and a self-etch (Clearfil SE Bond: CF) adhesive systems. Restored teeth (n=10)/group were sectioned into sticks and submitted to different analyses: micro-Raman determined the degree of conversion inside the hybrid layer (DC); resin-dentin microtensile bond strength and fracture pattern analysis at 24h, 1year and 2 years of aging; and nanoleakage evaluation at 24h and 2 years...
December 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28326785/two-dimensional-infrared-spectroscopy-reveals-cosolvent-composition-dependent-crossover-in-intermolecular-hydrogen-bond-dynamics
#15
Somnath M Kashid, Geun Young Jin, Suman Chakrabarty, Yung Sam Kim, Sayan Bagchi
Cosolvents have versatile composition-dependent applications in chemistry and biology. The simultaneous presence of hydrophobic and hydrophilic groups in dimethyl sulfoxide (DMSO), an industrially important amphiphilic cosolvent, when combined with the unique properties of water, plays key roles in the diverse fields of pharmacology, cryoprotection, and cell biology. Moreover, molecules dissolved in aqueous DMSO exhibit an anomalous concentration-dependent nonmonotonic behavior in stability and activity near a critical DMSO mole fraction of 0...
March 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28324159/hibernation-based-blood-loss-therapy-increases-survivability-of-lethal-hemorrhagic-shock-in-rats
#16
Cecilia E Perez de Lara Rodriguez, Lester R Drewes, Matthew T Andrews
A small-volume (1 ml/kg) resuscitation fluid based on metabolic adaptations in hibernating mammals was optimized using a rat model of hemorrhagic shock. A previous study of this therapy tested only one concentration of three specific components: 4 M D-stereoisomer of beta-hydroxybutyrate (BHB), 43 mM melatonin, and 20% DMSO. In this study, we considered the range of concentrations of BHB and melatonin seen during the physiological extremes of rapid arousal from hypothermic torpor in natural hibernators and applied these to the non-hibernating Sprague-Dawley rat model...
March 21, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28323109/self-emulsifying-drug-delivery-systems-design-of-a-novel-vaginal-delivery-system-for-curcumin
#17
S Köllner, I Nardin, R Markt, J Griesser, F Prüfert, A Bernkop-Schnürch
AIM: The aim of this study was to develop a vaginal self-emulsifying delivery system for curcumin being capable of spreading, of permeating the mucus gel layer and of protecting the drug being incorporated in oily nanodroplets towards mucus interactions and immobilization. METHODS: The emulsifying properties of curcumin loaded SEDDS containing 30% Cremophor RH40, 20% Capmul PG-8, 30% Captex 300, 10% DMSO and 10% tetraglycol (SEDD formulation A) as well as 25% PEG 200, 35% Cremophor RH40, 20% Captex 355, 10% Caprylic acid and 10% Tween 80 (SEDD formulation B) after diluting 1+2 with artificial vaginal fluid were characterized regarding droplet size and zeta potential...
March 17, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28322568/transition-metal-free-atom-and-step-economic-synthesis-of-aminoketopyrrolizines-from-benzylamine-acylethynylpyrroles-and-acylacetylenes
#18
Lyubov' N Sobenina, Denis N Tomilin, Elena F Sagitova, Igor' A Ushakov, Boris A Trofimov
A concise, atom-economic strategy for the synthesis of pyrrolizines with amino and keto substituents has been developed. It includes the following key steps: (i) the base-catalyzed (K3PO4/DMSO) addition of a benzylamine to 2-acylethynylpyrroles and (ii) noncatalyzed addition of enaminones obtained to the triple bond of acylacetylenes followed by intramolecular cyclization of the intermediate pentadiendiones thus formed to the target 1-(benzylamino)-2-acyl-3-methylenoacylpyrrolizines.
March 21, 2017: Organic Letters
https://www.readbyqxmd.com/read/28319797/non-enolisable-knoevenagel-condensate-appended-schiff-bases-metal-ii-complexes-spectral-characteristics-dna-binding-and-nuclease-activities
#19
Ammavasi Gubendran, Mookkandi Palsamy Kesavan, Srinivasan Ayyanaar, Liviu Mitu, Periyakaruppan Athappan, Jegathalaprathaban Rajesh
New Schiff base complexes [Cu(L(1))Cl] (1), [Ni(L(1))Cl] (2), [Zn(L(1))Cl] (3), and [Fe(L(2))H2OCl] (4) {L(1)=(4E)-3-(2-hydroxybenzylidene)-4-(2-hydroxyphenylimino)pentan-2-one, L(2)=2,2'-(1E,1'E)-(3-(2-hydroxybenzylidene)-pentane-2,4-diylidene)bis(azan-1-yl-1 idene)diphenol} have been synthesized and characterized by elemental analysis, UV-Vis, IR, FAB-mass, EPR, spectral studies and electrochemical studies, the ligands L(1) &L(2) were characterized by (1)H and (13)C NMR spectra. Complex 1 show a visible spectral d-d band near 600nm and display cyclic voltammetric quasireversible response for the Cu(II)/Cu(I) couple vs Ag/AgCl in DMSO...
March 16, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28317989/metal-free-oxidative-ring-contraction-of-benzodiazepinones-an-entry-to-quinoxalinones
#20
Hasan Mtiraoui, Kevin Renault, Morgane Sanselme, Moncef Msaddek, Pierre-Yves Renard, Cyrille Sabot
A novel and practical synthesis of 3-benzoylquinoxalin-2(1H)-ones from benzodiazepin-2-ones in two steps from commercially available starting materials is reported. The reaction was achieved in the presence of N-bromosuccinimide in DMSO which served both as a solvent and an oxidant. Significantly, the yet unknown ketone to alcohol fluorescence turn-on of benzoylquinoxalinones was unveiled through the preparation of a fluorescently labelled cholesterol conjugate.
March 20, 2017: Organic & Biomolecular Chemistry
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