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https://www.readbyqxmd.com/read/29769805/genome-wide-sequencing-technologies-a-primer-for-paediatricians
#1
Robin Z Hayeems, Kym M Boycott
Genetic testing has been a routine part of paediatic medicine for decades. Over time, the number of genetic tests available for children presenting with features thought to be explained by an underlying genetic aetiology has expanded considerably. Genome-wide sequencing approaches (e.g., whole-exome sequencing, whole-genome sequencing) are now emerging as the most comprehensive approaches to genetic diagnosis that we have seen to date; multiple serial tests that were once required for a child under diagnostic investigation can now be accomplished in a single assay...
May 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29765335/heart-rate-variability-during-a-joint-attention-task-in-toddlers-with-autism-spectrum-disorders
#2
Lucia Billeci, Alessandro Tonacci, Antonio Narzisi, Zaira Manigrasso, Maurizio Varanini, Francesca Fulceri, Caterina Lattarulo, Sara Calderoni, Filippo Muratori
Background: Autism Spectrum Disorders (ASD) are a heterogeneous group of neurodevelopmental disorders featuring early impairments in social domain, with autonomic nervous system (ANS) unbalance possibly representing a useful marker for such disturbances. Impairments in joint attention (JA) are one of the earliest markers of social deficits in ASD. In this study, we assessed the feasibility of using wearable technologies for characterizing the ANS response in ASD toddlers during the presentation of JA stimuli...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29656914/results-of-an-rct-in-two-pediatric-emergency-departments-to-evaluate-the-efficacy-of-an-m-health-educational-app-on-car-seat-use
#3
Andrea C Gielen, David M Bishai, Elise Omaki, Wendy C Shields, Eileen M McDonald, Nicholas C Rizzutti, James Case, Molly W Stevens, Mary E Aitken
INTRODUCTION: The growing interest in incorporating prevention into emergency health care make it timely to examine the use of computer technology to efficiently deliver effective education in this setting. STUDY DESIGN: This RCT compared results from an intervention group (n=367) that received child passenger safety information, to an attention-matched control (n=375). A baseline survey and two follow-up surveys at 3 and 6 months were conducted. SETTING/PARTICIPANTS: Data were collected from June 2014 to September 2016 from a sample of parents with children aged 4-7 years recruited from a pediatric emergency department in an East Coast urban area and one in a Midwest semi-rural area...
April 9, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29627424/asthma-across-the-lifespan-time-for-a-paradigm-shift
#4
Stanley J Szefler
We have a unique opportunity to significantly reduce the worldwide burden of asthma in children and impact respiratory outcomes in adults. However, this will require a paradigm shift that is directed at altering the natural history of asthma, reducing asthma exacerbations and preventing long-term adverse outcomes of childhood asthma. Attention should continue to be directed toward minimizing risk as well as impairment with a goal to achieve optimal control. Based on several NIH studies conducted over the last 10 years we now have the tools necessary to accomplish this goal...
April 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29610109/improvement-of-attention-deficit-hyperactivity-disorder-symptoms-in-school-aged-children-adolescents-and-young-adults-with-autism-via-a-digital-smartglasses-based-socioemotional-coaching-aid-short-term-uncontrolled-pilot-study
#5
Arshya Vahabzadeh, Neha U Keshav, Joseph P Salisbury, Ned T Sahin
BACKGROUND: People with autism spectrum disorder (ASD) commonly experience symptoms related to attention-deficit/hyperactivity disorder (ADHD), including hyperactivity, inattention, and impulsivity. One-third of ASD cases may be complicated by the presence of ADHD. Individuals with dual diagnoses face greater barriers to accessing treatment for ADHD and respond less positively to primary pharmacologic interventions. Nonpharmacologic technology-aided tools for hyperactivity and inattention in people with ASD are being developed, although research into their efficacy and safety remains limited...
March 24, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29608989/advances-challenges-and-promises-in-pediatric-neuroimaging-of-neurodevelopmental-disorders
#6
REVIEW
Haley M Bednarz, Rajesh K Kana
Recent years have witnessed the proliferation of neuroimaging studies of neurodevelopmental disorders (NDDs), particularly of children with autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and Tourette's syndrome (TS). Neuroimaging offers immense potential in understanding the biology of these disorders, and how it relates to clinical symptoms. Neuroimaging techniques, in the long run, may help identify neurobiological markers to assist clinical diagnosis and treatment. However, methodological challenges have affected the progress of clinical neuroimaging...
March 31, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29538778/vehicular-hyperthermia-a-highly-preventable-and-potentially-fatal-problem
#7
M Denise Dowd
A child dying of heat injury due to being left unattended in a motor vehicle is a needless tragedy. Each year in the United States an average of 38 children mostly younger than age 2 years die of vehicular hyperthermia, frequently the result of a parental lapse of attention and not intentional neglect. Serious illness results quickly from exposure to rising heat within the passenger compartment, even on days when the temperature is fairly moderate. Prevention is paramount in addressing this problem and can best be accomplished by a combination of technological means, such as passive warning systems, laws that make leaving a child in a car alone illegal, and public education campaigns...
March 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29527625/reduced-alternating-gaze-during-social-interaction-in-infancy-is-associated-with-elevated-symptoms-of-autism-in-toddlerhood
#8
Emilia Thorup, Pär Nyström, Gustaf Gredebäck, Sven Bölte, Terje Falck-Ytter
In typical development, infants often alternate their gaze between their interaction partners and interesting stimuli, increasing the probability of joint attention toward surrounding objects and creating opportunities for communication and learning. Children with Autism Spectrum Disorder (ASD) have been found to engage less in behaviors that can initiate joint attention compared to typically developing children, but the role of such atypicalities in the development of ASD during infancy is not fully understood...
March 12, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29422151/interdisciplinary-ugandan-perspectives-on-computerized-intervention-implementation-for-child-survivors-of-severe-malaria-a-qualitative-analysis
#9
Katherine Finn, Jody Lori, Maurgan Lee, Bruno Giordani
PURPOSE: Severe malaria (SM) is the leading cause of pediatric cognitive impairment in sub-Saharan Africa. Computerized Cognitive Rehabilitation Therapy (CCRT), a promising intervention for children suffering from SM related cognitive delay, targets areas impacted by the disease (memory, attention, and executive function), but has yet to be implemented for daily use. This paper explores the perspectives of Ugandan professionals regarding CCRT implementation in the academic setting of Uganda...
February 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29287205/novel-names-extend-for-how-long-preschool-children-sample-visual-information
#10
Paulo F Carvalho, Catarina Vales, Caitlin M Fausey, Linda B Smith
Known words can guide visual attention, affecting how information is sampled. How do novel words, those that do not provide any top-down information, affect preschoolers' visual sampling in a conceptual task? We proposed that novel names can also change visual sampling by influencing how long children look. We investigated this possibility by analyzing how children sample visual information when they hear a sentence with a novel name versus without a novel name. Children completed a match-to-sample task while their moment-to-moment eye movements were recorded using eye-tracking technology...
April 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29234356/the-opportunities-of-virtual-reality-in-the-rehabilitation-of-children-with-attention-deficit-hyperactivity-disorder-a-literature-review
#11
REVIEW
Azadeh Bashiri, Marjan Ghazisaeedi, Leila Shahmoradi
Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in childhood. This disorder, in addition to its main symptoms, creates significant difficulties in education, social performance, and personal relationships. Given the importance of rehabilitation for these patients to combat the above issues, the use of virtual reality (VR) technology is helpful. The aim of this study was to highlight the opportunities for VR in the rehabilitation of children with ADHD. This narrative review was conducted by searching for articles in scientific databases and e-Journals, using keywords including VR, children, and ADHD...
November 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29232173/tele-pediatric-intensive-care-for-critically-ill-children-in-syria
#12
Muhammad Bakr Ghbeis, Katherine M Steffen, Elizabeth A Braunlin, Gregory J Beilman, Jay Dahman, Waseem Ostwani, Marie E Steiner
BACKGROUND: Armed conflicts can result in humanitarian crises and have major impacts on civilians, of whom children represent a significant proportion. Usual pediatric medical care is often disrupted and trauma resulting from war-related injuries is often devastating. High pediatric mortality rates are thus experienced in these ravaged medical environments. INTRODUCTION: Using simple communication technology to provide real-time management recommendations from highly trained pediatric personnel can provide substantive clinical support and have a significant impact on pediatric morbidity and mortality...
December 12, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29224769/evaluation-of-speech-reception-threshold-in-noise-in-young-cochlear%C3%A2-nucleus-%C3%A2-system-6-implant-recipients-using-two-different-digital-remote-microphone-technologies-and-a-speech-enhancement-sound-processing-algorithm
#13
Sergio Razza, Monica Zaccone, Aannalisa Meli, Eliana Cristofari
OBJECTIVE: Children affected by hearing loss can experience difficulties in challenging and noisy environments even when deafness is corrected by Cochlear implant (CI) devices. These patients have a selective attention deficit in multiple listening conditions. At present, the most effective ways to improve the performance of speech recognition in noise consists of providing CI processors with noise reduction algorithms and of providing patients with bilateral CIs. The aim of this study was to compare speech performances in noise, across increasing noise levels, in CI recipients using two kinds of wireless remote-microphone radio systems that use digital radio frequency transmission: the Roger Inspiro accessory and the Cochlear Wireless Mini Microphone accessory...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29222634/what-is-the-level-of-evidence-for-the-use-of-currently-available-technologies-in-facilitating-the-self-management-of-difficulties-associated-with-adhd-in-children-and-young-people-a-systematic-review
#14
REVIEW
Lauren Powell, Jack Parker, Valerie Harpin
A number of technologies to help self-manage attention deficit hyperactivity disorder (ADHD) in children and young people (YP) have been developed. This review will assess the level of evidence for the use of such technologies. The review was undertaken in accordance with the general principles recommended in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. 7545 studies were screened. Fourteen studies of technology that aim to self-manage difficulties associated with ADHD in children and YP were included...
December 8, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29221915/structural-brain-development-a-review-of-methodological-approaches-and-best-practices
#15
REVIEW
Nandita Vijayakumar, Kathryn L Mills, Aaron Alexander-Bloch, Christian K Tamnes, Sarah Whittle
Continued advances in neuroimaging technologies and statistical modelling capabilities have improved our knowledge of structural brain development in children and adolescents. While this has provided an increasingly nuanced understanding of brain development, the field is still plagued by inconsistent findings. This review highlights the methodological diversity in existing longitudinal magnetic resonance imaging (MRI) studies on structural brain development during childhood and adolescence, and addresses how such variation might contribute to inconsistencies in the literature...
November 22, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29191497/recontacting-in-light-of-new-genetic-diagnostic-techniques-for-patients-with-intellectual-disability-feasibility-and-parental-perspectives
#16
Gea Beunders, Melodi Dekker, Oscar Haver, Hanne J Meijers-Heijboer, Lidewij Henneman
A higher diagnostic yield from new diagnostic techniques makes re-evaluation in patients with intellectual disability without a causal diagnosis valuable, and is currently only performed after new referral. Active recontacting might serve a larger group of patients. We aimed to evaluate parental perspectives regarding recontacting and its feasibility in clinical genetic practice. A recontacting pilot was performed in two cohorts of children with intellectual disability. In cohort A, parents were recontacted by phone and in cohort B by letter, to invite them for a re-evaluation due to the new technologies (array CGH and exome sequencing, respectively)...
November 27, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29161215/recent-advances-in-nanomedicine-and-survivin-targeting-in-brain-cancers
#17
Jake Mazur, Kislay Roy, Jagat R Kanwar
Brain cancer is a highly lethal disease, especially devastating toward both the elderly and children. This cancer has no therapeutics available to combat it, predominately due to the blood-brain barrier (BBB) preventing treatments from maintaining therapeutic levels within the brain. Recently, nanoparticle technology has entered the forefront of cancer therapy due to its ability to deliver therapeutic effects while potentially passing physiological barriers. Key nanoparticles for brain cancer treatment include glutathione targeted PEGylated liposomes, gold nanoparticles, superparamagnetic iron oxide nanoparticles and nanoparticle-albumin bound drugs, with these being discussed throughout this review...
January 2018: Nanomedicine
https://www.readbyqxmd.com/read/29155488/effectiveness-of-a-virtual-reality-intervention-to-minimize-pediatric-stress-and-pain-intensity-during-venipuncture
#18
Joanna Piskorz, Marcin Czub
PURPOSE: Virtual reality (VR) technology is an effective tool in treatment of acute pain. Numerous studies show the effectiveness of this method both in a clinical context and in the laboratory. However, research results on the effectiveness of VR in pediatric venipuncture pain is not conclusive-not all studies report the analgesic effect of VR. In addition to testing effectiveness of VR, we also assess the usability of a novel hands-free interface. DESIGN AND METHODS: Patients of paediatric nephrology clinic (N = 38; mean age 11 years, range 7-17) participated in a posttest only between group quasi-experimental study...
January 2018: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/29155369/virtual-rehabilitation-with-children-challenges-for-clinical-adoption-from-the-field
#19
Stephanie Glegg
Virtual, augmented, and mixed reality environments are increasingly being developed and used to address functional rehabilitation goals related to physical, cognitive, social, and psychological impairments. For example, a child with an acquired brain injury may participate in virtual rehabilitation to address impairments in balance, attention, turn taking, and engagement in therapy. The trend toward virtual rehabilitation first gained momentum with the adoption of commercial off-the-shelf active video gaming consoles (e...
November 2017: IEEE Pulse
https://www.readbyqxmd.com/read/29135444/-validation-of-hungarian-smartphone-deprivation-inventory-hsdi-with-school-children
#20
Sándor Csibi, Zsolt Demetrovics, Attila Szabo
The widespread use of smartphones generates new habits and behaviors among the users, including schoolchildren. Advance technology-based applications, capturing interest and attention, influence cognitive focus and time spent with the device. Examination of these factors points toward the risk of addiction, as well as the deprivations sensations associated with the latter, that call for scholastic attention. AIM: The aim of this study was to validate a Hungarian Smartphone Deprivation Inventory (HSDI), to gauge the deprivation feelings and their severity in schoolchildren when they cannot access their device...
2017: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
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