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https://www.readbyqxmd.com/read/28442423/slc6a1-gene-involvement-in-susceptibility-to-attention-deficit-hyperactivity-disorder-a-case-control-study-and-gene-environment-interaction
#1
Fang-Fen Yuan, Xue Gu, Xin Huang, Yan Zhong, Jing Wu
Attention-deficit/hyperactivity disorder (ADHD) is an early onset childhood neurodevelopmental disorder with an estimated heritability of approximately 76%. We conducted a case-control study to explore the role of the SLC6A1 gene in ADHD. The genotypes of eight variants were determined using Sequenom MassARRAY technology. The participants in the study were 302 children with ADHD and 411 controls. ADHD symptoms were assessed using the Conners Parent Symptom Questionnaire. In our study, rs2944366 was consistently shown to be associated with the ADHD risk in the dominant model (odds ratio [OR]=0...
April 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28439428/current-standards-in-abdominal-cavity-ultrasound-examination-in-children
#2
REVIEW
Michał Brzewski
Technological progress forces us to present after several years the updated standards in ultrasound examination of newborns, infants and older children. It should be emphasized that the examination of the youngest patients requires one to use high-class equipment. Lack of cooperation on the part of the child and imaging small structures constitute a huge challenge for the examiner. The work presents equipment requirements, the technology of examining the abdominal cavity in children and the manner of preparing the examination result...
March 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28437730/the-practice-of-prosecuting-child-maltreatment-results-of-an-online-survey-of-prosecutors
#3
Theodore P Cross, Debra Whitcomb
Despite efforts by advocates, practitioners, and legislators to alleviate the burden on child maltreatment victims in the criminal justice system, many challenges remain for prosecutors as they seek to hold offenders accountable while minimizing the emotional impact on children. More than 200 state and local prosecutors in 37 states responded to an online survey to share their perspectives on current challenges, procedures to support children in the adjudication process, and the impact of the U.S. Supreme Court opinion in Crawford v...
April 21, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28413717/advances-of-cd19-directed-chimeric-antigen-receptor-modified-t-cells-in-refractory-relapsed-acute-lymphoblastic-leukemia
#4
REVIEW
Guoqing Wei, Lijuan Ding, Jiasheng Wang, Yongxian Hu, He Huang
Refractory/relapsed B-cell acute lymphoblastic leukemia remains to be a significant cause of cancer-associated morbidity and mortality for children and adults. Developing novel and effective molecular-targeted approaches is thus a major priority. Chimeric antigen receptor-modified T cell (CAR-T) therapy, as one of the most promising targeted immunotherapies, has drawn extensive attention and resulted in multiple applications. According to published studies, CD19-directed CAR-T cells (CD19 CAR-T) can reach a complete remission rate of 94% in both children and adults with refractory/relapsed ALL, much higher than that of chemotherapy...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/28375179/perspectives-on-technology-assisted-relaxation-approaches-to-support-mind-body-skills-practice-in-children-and-teens-clinical-experience-and-commentary
#5
Timothy Culbert
It has been well-established that a variety of mind-body (MB) techniques, including yoga, mental imagery, hypnosis, biofeedback, and meditation, are effective at addressing symptoms such as pain, anxiety, nausea, and insomnia, as well as helping with a wide variety of medical, emotional, and behavioral issues in pediatric populations. In addition, MB skills can also be health promoting in the long-term, and with regular practice, could potentially contribute to longer attention spans, social skills, emotional regulation, and enhanced immune system functioning...
April 4, 2017: Children
https://www.readbyqxmd.com/read/28353291/problematic-technology-use-in-a-clinical-sample-of-children-and-adolescents-personality-and-behavioral-problems-associated
#6
Cristina Alonso, Estrella Romero
INTRODUCTION: In parallel to the rapid growth of access to new technologies (NT) there has been an increase in the problematic use of the same, especially among children and adolescents. Although research in this field is increasing, the studies have mainly been developed in the community, and the characteristics associated with the problematic use of NT are unknown in samples that require clinical care. Therefore, the aim of this study is to analyze the relationship between problematic use of video games (UPV) and Internet (UPI) and personality traits and behavior problems in a clinical sample of children and adolescents...
March 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/28351944/defining-pediatric-chronic-critical-illness-for-clinical-care-research-and-policy
#7
Miriam C Shapiro, Carrie M Henderson, Nancy Hutton, Renee D Boss
Chronically critically ill pediatric patients represent an emerging population in NICUs and PICUs. Chronic critical illness has been recognized and defined in the adult population, but the same attention has not been systematically applied to pediatrics. This article reviews what is currently known about pediatric chronic critical illness, highlighting the unique aspects of chronic critical illness in infants and children, including specific considerations of prognosis, outcomes, and decision-making. We propose a definition that incorporates NICU versus PICU stays, recurrent ICU admissions, dependence on life-sustaining technology, multiorgan dysfunction, underlying medical complexity, and the developmental implications of congenital versus acquired conditions...
March 28, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28345387/multimodal-treatment-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-a-6-month-follow-up
#8
Nezla S Duric, Jørg Assmus, Doris Gundersen, Alisa Duric Golos, Irene B Elgen
BACKGROUND: Different treatment approaches aimed at reducing attention-deficit/hyperactivity disorder (ADHD) core symptoms are available. However, factors such as intolerance, side-effects, lack of efficacy, high new technology costs, and placebo effect have spurred on an increasing interest in alternative or complementary treatment. AIM: The aim of this study is to explore efficacy of multimodal treatment consisting of standard stimulant medication (methylphenidate) and neurofeedback (NF) in combination, and to compare it with the single treatment in 6-month follow-up in ADHD children and adolescents...
March 27, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28327383/sigueme-technology-based-intervention-for-low-functioning-autism-to-train-skills-to-work-with-visual-signifiers-and-concepts
#9
María Vélez-Coto, María José Rodríguez-Fórtiz, María Luisa Rodriguez-Almendros, Marcelino Cabrera-Cuevas, Carlos Rodríguez-Domínguez, Tomás Ruiz-López, Ángeles Burgos-Pulido, Inmaculada Garrido-Jiménez, Juan Martos-Pérez
BACKGROUND: People with low-functioning ASD and other disabilities often find it difficult to understand the symbols traditionally used in educational materials during the learning process. Technology-based interventions are becoming increasingly common, helping children with cognitive disabilities to perform academic tasks and improve their abilities and knowledge. Such children often find it difficult to perform certain tasks contained in educational materials since they lack necessary skills such as abstract reasoning...
March 16, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28304115/extracorporeal-photopheresis-in-pediatric-patients-practical-and-technical-considerations
#10
Robert A DeSimone, Joseph Schwartz, Jennifer Schneiderman
In adults, extracorporeal photopheresis (ECP) is widely utilized for a variety of indications, most commonly cutaneous T-cell lymphoma, acute or chronic graft-versus-host disease (GVHD), solid organ transplant rejection, and other autoimmune and T-cell-mediated disorders. In pediatric patients, the majority of case series and reports have focused on its use in the management of acute and chronic GVHD. Currently utilized ECP technologies were designed for adult patients and there are several challenges in adapting these technologies for use in children...
March 17, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28302740/genetics-and-genomics-of-congenital-heart-disease
#11
Samir Zaidi, Martina Brueckner
Congenital heart disease is the most common birth defect, and because of major advances in medical and surgical management, there are now more adults living with congenital heart disease (CHD) than children. Until recently, the cause of the majority of CHD was unknown. Advances in genomic technologies have discovered the genetic causes of a significant fraction of CHD, while at the same time pointing to remarkable complexity in CHD genetics. This review will focus on the evidence for genetic causes underlying CHD and discuss data supporting both monogenic and complex genetic mechanisms underlying CHD...
March 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/28257875/game-based-combined-cognitive-and-neurofeedback-training-using-focus-pocus-reduces-symptom-severity-in-children-with-diagnosed-ad-hd-and-subclinical-ad-hd
#12
Stuart J Johnstone, Steven J Roodenrys, Kirsten Johnson, Rebecca Bonfield, Susan J Bennett
Previous studies report reductions in symptom severity after combined working memory (WM) and inhibitory control (IC) training in children with AD/HD. Based on theoretical accounts of the role of arousal/attention modulation problems in AD/HD, the current study examined the efficacy of combined WM, IC, and neurofeedback training in children with AD/HD and subclinical AD/HD. Using a randomized waitlist control design, 85 children were randomly allocated to a training or waitlist condition and completed pre- and post-training assessments of overt behavior, trained and untrained cognitive task performance, and resting and task-related EEG activity...
February 28, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28184210/attachment-avoidance-is-significantly-related-to-attentional-preference-for-infant-faces-evidence-from-eye-movement-data
#13
Yuncheng Jia, Gang Cheng, Dajun Zhang, Na Ta, Mu Xia, Fangyuan Ding
Objective: To determine the influence of adult attachment orientations on infant preference. Methods: We adopted eye-tracking technology to monitor childless college women's eye movements when looking at pairs of faces, including one adult face (man or woman) and one infant face, with three different expressions (happy, sadness, and neutral). The participants (N = 150; 84% Han ethnicity) were aged 18-29 years (M = 19.22, SD = 1.72). A random intercepts multilevel linear regression analysis was used to assess the unique contribution of attachment avoidance, determined using the Experiences in Close Relationships scale, to preference for infant faces...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28056653/a-statistical-physics-perspective-to-understand-social-visual-attention-in-autism-spectrum-disorder
#14
Alessio Liberati, Roberta Fadda, Giuseppe Doneddu, Sara Congiu, Marco A Javarone, Tricia Striano, Alessandro Chessa
This study investigated social visual attention in children with Autism Spectrum Disorder (ASD) and with typical development (TD) in the light of Brockmann and Geisel's model of visual attention. The probability distribution of gaze movements and clustering of gaze points, registered with eye-tracking technology, was studied during a free visual exploration of a gaze stimulus. A data-driven analysis of the distribution of eye movements was chosen to overcome any possible methodological problems related to the subjective expectations of the experimenters about the informative contents of the image in addition to a computational model to simulate group differences...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/28028968/the-use-of-3d-printing-technology-in-the-ilizarov-method-treatment-pilot-study
#15
Karolina Burzyńska, Piotr Morasiewicz, Jarosław Filipiak
BACKGROUND: Significant developments in additive manufacturing technology have occurred in recent years. 3D printing techniques can also be helpful in the Ilizarov method treatment. OBJECTIVES: The aim of this study was to evaluate the usefulness of 3D printing technology in the Ilizarov method treatment. MATERIAL AND METHODS: Physical models of bones used to plan the spatial design of Ilizarov external fixator were manufactured by FDM (Fused Deposition Modeling) spatial printing technology...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28018271/comparing-a-perceptual-and-an-automated-vision-based-method-for-lie-detection-in-younger-children
#16
Mariana Serras Pereira, Reinier Cozijn, Eric Postma, Suleman Shahid, Marc Swerts
The present study investigates how easily it can be detected whether a child is being truthful or not in a game situation, and it explores the cue validity of bodily movements for such type of classification. To achieve this, we introduce an innovative methodology - the combination of perception studies (in which eye-tracking technology is being used) and automated movement analysis. Film fragments from truthful and deceptive children were shown to human judges who were given the task to decide whether the recorded child was being truthful or not...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27973718/human-nuclear-genome-transfer-so-called-mitochondrial-replacement-clearing-the-underbrush
#17
Françoise Baylis
In this article, I argue that there is no compelling therapeutic 'need' for human nuclear genome transfer (so-called mitochondrial replacement) to prevent mitochondrial diseases caused by mtDNA mutations. At most there is a strong interest in (i.e. 'want' for) this technology on the part of some women and couples at risk of having children with mitochondrial disease, and perhaps also a 'want' on the part of some researchers who see the technology as a useful precedent - one that provides them with 'a quiet way station' in which to refine the micromanipulations techniques essential for other human germline interventions and human cloning...
January 2017: Bioethics
https://www.readbyqxmd.com/read/27943285/annual-research-review-digital-health-interventions-for-children-and-young-people-with-mental-health-problems-a-systematic-and-meta-review
#18
REVIEW
Chris Hollis, Caroline J Falconer, Jennifer L Martin, Craig Whittington, Sarah Stockton, Cris Glazebrook, E Bethan Davies
BACKGROUND: Digital health interventions (DHIs), including computer-assisted therapy, smartphone apps and wearable technologies, are heralded as having enormous potential to improve uptake and accessibility, efficiency, clinical effectiveness and personalisation of mental health interventions. It is generally assumed that DHIs will be preferred by children and young people (CYP) given their ubiquitous digital activity. However, it remains uncertain whether: DHIs for CYP are clinically and cost-effective, CYP prefer DHIs to traditional services, DHIs widen access and how they should be evaluated and adopted by mental health services...
April 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27940422/data-as-a-service-platform-for-delivering-healthy-lifestyle-and-preventive-medicine-concept-and-structure-of-the-daphne-project
#19
Catherine Gibbons, Gonzalo Bailador Del Pozo, Javier Andrés, Tim Lobstein, Melania Manco, Hadas Lewy, Einat Bergman, David O'Callaghan, Gavin Doherty, Olga Kudrautseva, Angel Palomares, Roni Ram, Alberto Olmo
BACKGROUND: Overweight and obesity is related to many health problems and diseases. The current obesity epidemic, which is a major health problem, is closely related to a lack of physical activity, high levels of sedentary behavior, and increased energy intake; with evidence to show increasing incidence of these issues in the younger population. Tackling obesity and its comorbid conditions requires a holistic approach encompassing attention on physical activity, healthy diet, and behavioral activation in order to enable and maintain meaningful and long-term weight loss and weight maintenance...
December 9, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27893572/pain-management-in-pediatric-burn-patients-review-of-recent-literature-and-future-directions
#20
Omar Pardesi, Gennadiy Fuzaylov
Childhood burns are a profoundly traumatic and painful experience. Despite recognition of the prevalence of burn injuries in children and the severity of the associated pain, burn pain remains undertreated. At the same time, more evidence is emerging to suggest that undertreated pain has serious long-term medical and psychiatric consequences, many of which can be ameliorated with improved pain control. Pain in burn patients is, however, notoriously difficult to treat, perhaps because there is a chronic pain aspect underlying the acute pain that accompanies wound care and procedures...
November 17, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
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