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https://www.readbyqxmd.com/read/29144726/physalis-mottle-virus-like-particles-as-nanocarriers-for-imaging-reagents-and-drugs
#1
Hema Masarapu, Bindi K Patel, Paul L Chariou, He Hu, Neetu M Gulati, Bradley L Carpenter, Reza A Ghiladi, Sourabh Shukla, Nicole F Steinmetz
Platform technologies based on plant virus nanoparticles (VNPs) and virus-like particles (VLPs) are attracting the attention of researchers and clinicians because the particles are biocompatible, biodegradable, noninfectious in mammals, and can readily be chemically and genetically engineered to carry imaging agents and drugs. When the Physalis mottle virus (PhMV) coat protein is expressed in Escherichia coli, the resulting VLPs are nearly identical to the viruses formed in vivo. Here, we isolated PhMV-derived VLPs from ClearColi cells and carried out external and internal surface modification with fluorophores using reactive lysine-N-hydroxysuccinimide ester and cysteine-maleimide chemistries, respectively...
November 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29143897/anaplastic-lymphoma-kinase-testing-ihc-vs-fish-vs-ngs
#2
REVIEW
Xiaomin Niu, Jody C Chuang, Gerald J Berry, Heather A Wakelee
Personalized targeted therapy has emerged as a promising strategy in lung cancer treatment, with current attention focused on elucidation and detection of oncogenic drivers responsible for tumor initiation and maintenance and development of drug resistance. In lung cancer, several oncogenic drivers have been reported, triggering the application of tyrosine kinase inhibitors (TKIs) to target these dysfunctional genes. The anaplastic lymphoma kinase (ALK) rearrangement is responsible for about 4-7% of all non-small cell lung cancers (NSCLCs) and perhaps as high as a third in specific patient populations such as younger, male, non-smokers with advanced stage, epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) wild type, and signet ring cell adenocarcinoma with abundant intracytoplasmic mucin...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29143764/road-lane-detection-robust-to-shadows-based-on-a-fuzzy-system-using-a-visible-light-camera-sensor
#3
Toan Minh Hoang, Na Rae Baek, Se Woon Cho, Ki Wan Kim, Kang Ryoung Park
Recently, autonomous vehicles, particularly self-driving cars, have received significant attention owing to rapid advancements in sensor and computation technologies. In addition to traffic sign recognition, road lane detection is one of the most important factors used in lane departure warning systems and autonomous vehicles for maintaining the safety of semi-autonomous and fully autonomous systems. Unlike traffic signs, road lanes are easily damaged by both internal and external factors such as road quality, occlusion (traffic on the road), weather conditions, and illumination (shadows from objects such as cars, trees, and buildings)...
October 28, 2017: Sensors
https://www.readbyqxmd.com/read/29140637/hazard-identification-and-risk-assessment-for-improving-farm-safety-on-canadian-farms
#4
Hassan S Chattha, Kenneth W Corscadden, Qamar U Zaman
Agriculture is one of the most hazardous industries worldwide. The number of serious accidents on farms, despite sophisticated technology, development of effective prevention methods, and high-quality training and improved skill levels of farmers, is still very high. The purpose of this study was to develop and apply a generic farm safety protocol to hazards that have been identified in previously published literature and demonstrate the potential benefits of such a protocol with a view to raising awareness of farm safety...
July 31, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29140309/biosensors-to-diagnose-chagas-disease-a-brief-review
#5
REVIEW
María-Isabel Rocha-Gaso, Luis-Jesús Villarreal-Gómez, Denis Beyssen, Frédéric Sarry, Marco-Antonio Reyna, Carlos-Napoleón Ibarra-Cerdeña
Chagas disease (CD), which mostly affects those living in deprived areas, has become one of Latin America's main public health problems. Effective prevention of the disease requires early diagnosis, initiation of therapy, and regular blood monitoring of the infected individual. However, the majority of the Trypanosoma cruzi infections go undiagnosed because of mild symptoms, limited access to medical attention and to a high variability in the sensitivity and specificity of diagnostic tests. Consequently, more affordable and accessible detection technologies capable of providing early diagnosis and T...
November 15, 2017: Sensors
https://www.readbyqxmd.com/read/29139285/subradiant-dipolar-interactions-in-plasmonic-nanoring-resonator-array-for-integrated-label-free-biosensing
#6
Yuzhang Liang, Hui Zhang, Wenqi Zhu, Amit Agrawal, Henri J Lezec, Lixia Li, Wei Peng, Yi Zou, Yan-Qing Lu, Ting Xu
With the development of advanced nanofabrication technologies over the last decade, plasmonic nanostructures have attracted wide attention for their potential in label-free biosensing applications. However, the sensing performance of nanostructured plasmonic sensors is primarily limited by the broad-linewidth features with low peak-to-dip signal ratio in the extinction spectra that result from strong radiative damping. Here, we propose and systematically investigate the in-plane and out-of-plane dipolar interactions in an array of plasmonic nanoring resonators that are from the spatial combination of classic nanohole and nanodisk structures...
November 15, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29138128/will-participatory-syndromic-surveillance-work-in-latin-america-piloting-a-mobile-approach-to-crowdsource-influenza-like-illness-data-in-guatemala
#7
José Tomás Prieto, Jorge H Jara, Juan Pablo Alvis, Luis R Furlan, Christian Travis Murray, Judith Garcia, Pierre-Jean Benghozi, Susan Cornelia Kaydos-Daniels
BACKGROUND: In many Latin American countries, official influenza reports are neither timely nor complete, and surveillance of influenza-like illness (ILI) remains thin in consistency and precision. Public participation with mobile technology may offer new ways of identifying nonmedically attended cases and reduce reporting delays, but no published studies to date have assessed the viability of ILI surveillance with mobile tools in Latin America. We implemented and assessed an ILI-tailored mobile health (mHealth) participatory reporting system...
November 14, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29137702/review-of-recent-developments-in-determining-volatile-organic-compounds-in-exhaled-breath-as-biomarkers-for-lung-cancer-diagnosis
#8
REVIEW
Jiemin Zhou, Zi-Ao Huang, Ujendra Kumar, David D Y Chen
Lung cancer is the most common cause of cancer deaths, its global incidence is rising, and continuing rises are predicted. The potential to diagnose lung cancers based on the determination of volatile organic compounds (VOCs) in human breath has been attracting increasing attention with the development of new techniques and methodologies. However, despite many reports of VOC profiling in lung cancer patients, little is known about how specific biomarkers relate to the biochemical pathways involved in lung cancer development, and there is still no reliable method for diagnosing lung cancer at the early stages...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29136513/facilitating-learning-through-an-international-virtual-collaborative-practice-a-case-study
#9
Monne Wihlborg, Elizabeth E Friberg, Karen M Rose, Linda Eastham
BACKGROUND: Internationalisation of higher education involving information and communication technology such as e-learning opens opportunities for innovative learning approaches across nations and cultures. OBJECTIVES: Describe a case in practice of collaborative and transformative learning in relation to 'internationalisation on home grounds' with the broader learning objective of 'becoming aware and knowledgeable'. DESIGN: A mutually developed project established a virtual international collaborative exchange for faculty and students using a course management software (MOODLE) and open access technology (Adobe CONNECT)...
November 4, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29135444/-validation-of-hungarian-smartphone-deprivation-inventory-hsdi-with-school-children
#10
Sándor Csibi, Zsolt Demetrovics, Attila Szabo
The widespread use of smartphones generates new habits and behaviors among the users, including schoolchildren. Advance technology-based applications, capturing interest and attention, influence cognitive focus and time spent with the device. Examination of these factors points toward the risk of addiction, as well as the deprivations sensations associated with the latter, that call for scholastic attention. AIM: The aim of this study was to validate a Hungarian Smartphone Deprivation Inventory (HSDI), to gauge the deprivation feelings and their severity in schoolchildren when they cannot access their device...
2017: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/29134429/self-driving-cars-and-engineering-ethics-the-need-for-a-system-level-analysis
#11
Jason Borenstein, Joseph R Herkert, Keith W Miller
The literature on self-driving cars and ethics continues to grow. Yet much of it focuses on ethical complexities emerging from an individual vehicle. That is an important but insufficient step towards determining how the technology will impact human lives and society more generally. What must complement ongoing discussions is a broader, system level of analysis that engages with the interactions and effects that these cars will have on one another and on the socio-technical systems in which they are embedded...
November 13, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29133284/the-association-of-health-literacy-and-electronic-health-literacy-with-self-efficacy-coping-and-caregiving-perceptions-among-carers-of-people-with-dementia-research-protocol-for-a-descriptive-correlational-study
#12
Areti Efthymiou, Nicos Middleton, Andreas Charalambous, Evridiki Papastavrou
BACKGROUND: In the last decade, electronic health (eHealth) literacy has attracted the attention of the scientific community, as it is associated with the self-management of patients with chronic diseases and the quality and cost of care. It is estimated that 80% of people with chronic diseases are cared for at home by a family member, friend, or relative. Informal carers are susceptible to physical and mental health problems, as well as social and financial hardships. Nevertheless, there seems to be a research gap in terms of carers' needs, skills, and available resources in the age of new technologies, with the vital role of eHealth literacy of the carers remaining unexplored...
November 13, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29132267/spatial-bias-induced-by-simple-addition-and-subtraction-from-eye-movement-evidence
#13
Rongjuan Zhu, Yangmei Luo, Xuqun You, Ziyu Wang
The associations between number and space have been intensively investigated. Recent studies indicated that this association could extend to more complex tasks, such as mental arithmetic. However, the mechanism of arithmetic-space associations in mental arithmetic was still a topic of debate. Thus, in the current study, we adopted an eye-tracking technology to investigate whether spatial bias induced by mental arithmetic was related with spatial attention shifts on the mental number line or with semantic link between the operator and space...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/29131073/an-introduction-to-contrast-enhanced-ultrasound-for-nephrologists
#14
Emily H Chang
Contrast-enhanced ultrasound (CEUS) is an emerging technology with no known nephrotoxicity. CEUS has been utilized in cardiac and abdominal imaging for decades in Asia and Europe and has recently received greater attention in the United States with its approval for characterization of indeterminate liver lesions. Emerging data suggest that CEUS has potential as a diagnostic imaging tool among individuals who have contraindications to CT and MRI. Few nephrologists are aware of CEUS and even fewer are aware of its potential applications among individuals with kidney disease...
November 9, 2017: Nephron
https://www.readbyqxmd.com/read/29130158/crispr-in-the-retina-evaluation-of-future-potential
#15
Galaxy Y Cho, Sally Justus, Jesse D Sengillo, Stephen H Tsang
Clustered regularly interspaced short palindromic repeats (CRISPR) has been gaining widespread attention for its ability for targeted genome surgery. In treating inherited retinal degenerations, gene therapies have had varied results; the ones effective in restoring eye sight are limited by transiency in its effect. Genome surgery, however, is a solution that could potentially provide the eye with permanent healthy cells. As retinal degenerations are irreversible and the retina has little regenerative potential, permanent healthy cells are vital for vision...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29129942/priorities-for-research-in-soil-ecology
#16
Nico Eisenhauer, Pedro M Antunes, Alison E Bennett, Klaus Birkhofer, Andrew Bissett, Matthew A Bowker, Tancredi Caruso, Baodong Chen, David C Coleman, Wietse de Boer, Peter de Ruiter, Thomas H DeLuca, Francesco Frati, Bryan S Griffiths, Miranda M Hart, Stephan Hättenschwiler, Jari Haimi, Michael Heethoff, Nobuhiro Kaneko, Laura C Kelly, Hans Petter Leinaas, Zoë Lindo, Catriona Macdonald, Matthias C Rillig, Liliane Ruess, Stefan Scheu, Olaf Schmidt, Timothy R Seastedt, Nico M van Straalen, Alexei V Tiunov, Martin Zimmer, Jeff R Powell
The ecological interactions that occur in and with soil are of consequence in many ecosystems on the planet. These interactions provide numerous essential ecosystem services, and the sustainable management of soils has attracted increasing scientific and public attention. Although soil ecology emerged as an independent field of research many decades ago, and we have gained important insights into the functioning of soils, there still are fundamental aspects that need to be better understood to ensure that the ecosystem services that soils provide are not lost and that soils can be used in a sustainable way...
July 2017: Pedobiologia
https://www.readbyqxmd.com/read/29128716/smartphone-based-bioanalytical-and-diagnosis-applications-a-review
#17
REVIEW
Suvardhan Kanchi, Myalowenkosi I Sabela, Phumlane Selby Mdluli, Inamuddin, Krishna Bisetty
A smartphone is a facile, handy-analytical device that makes our lives comfortable and stress-free in terms of health care diagnostic assessments. Due to recent advancements in the technology and the introduction of user friendly operating systems and applications, the smartphones have replaced laptops and desktop computers. Taking this fact into account, researchers have designed sensing systems which are more compatible with smartphones. Consequently, these devices are attracting the attention of researchers from fields such as telemedicine, biotechnology, chemical sciences and environmental sciences...
November 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29127631/the-impact-of-urbanization-on-co2-emissions-in-china-an-empirical-study-using-1980-2014-provincial-data
#18
Shijin Wang, Cunfang Li
Towns and cities are not only the focus of attention for their consumption of energy and resources; they are also scrutinized closely for their emissions of greenhouse gases. China's urbanization level now exceeds 50%, but there is still much disparity compared with the level of urbanization in developed countries. This study selects China's urban population and carbon emissions data for the years 1980-2014 and discusses the timing and cause effect of urbanization and the corresponding carbon emissions using the Granger causality test and an error correction model (ECM) then uses STIRPAT models to extract six indicators to measure the quality of urbanization, namely, the level of urbanization, area of built-up regions, added value of tertiary industries, disposable income per capita, green areas per capita, and energy intensity...
November 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29125958/investigation-of-brain-science-and-neurological-psychiatric-disorders-using-genetically-modified-non-human-primates
#19
REVIEW
Hideyuki Okano, Noriyuki Kishi
Although mice have been the most frequently used experimental animals in many research fields due to well-established gene manipulation techniques, recent evidence has revealed that rodent models do not always recapitulate pathophysiology of human neurological and psychiatric diseases due to the differences between humans and rodents. The recent developments in gene manipulation of non-human primate have been attracting much attention in the biomedical research field, because non-human primates have more applicable brain structure and function than rodents...
November 7, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29125541/the-dark-side-of-the-epitranscriptome-chemical-modifications-in-long-non-coding-rnas
#20
REVIEW
Roland Jacob, Sindy Zander, Tony Gutschner
The broad application of next-generation sequencing technologies in conjunction with improved bioinformatics has helped to illuminate the complexity of the transcriptome, both in terms of quantity and variety. In humans, 70-90% of the genome is transcribed, but only ~2% carries the blueprint for proteins. Hence, there is a huge class of non-translated transcripts, called long non-coding RNAs (lncRNAs), which have received much attention in the past decade. Several studies have shown that lncRNAs are involved in a plethora of cellular signaling pathways and actively regulate gene expression via a broad selection of molecular mechanisms...
November 10, 2017: International Journal of Molecular Sciences
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