Maria Rosa Costanzo, Daniel Negoianu, Brian E Jaski, Bradley A Bart, James T Heywood, Inder S Anand, James M Smelser, Alan M Kaneshige, Don B Chomsky, Eric D Adler, Garrie J Haas, James A Watts, Jose L Nabut, Michael P Schollmeyer, Gregg C Fonarow
OBJECTIVES: The AVOID-HF (Aquapheresis versus Intravenous Diuretics and Hospitalization for Heart Failure) trial tested the hypothesis that patients hospitalized for HF treated with adjustable ultrafiltration (AUF) would have a longer time to first HF event within 90 days after hospital discharge than those receiving adjustable intravenous loop diuretics (ALD). BACKGROUND: Congestion in hospitalized heart failure (HF) patients portends unfavorable outcomes. METHODS: The AVOID-HF trial, designed as a multicenter, 1-to-1 randomized study of 810 hospitalized HF patients, was terminated unilaterally and prematurely by the sponsor (Baxter Healthcare, Deerfield, Illinois) after enrollment of 224 patients (27...
February 2016: JACC. Heart Failure