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https://www.readbyqxmd.com/read/29340992/prospective-comparative-study-of-laparoscopic-narrow-band-imaging-nbi-versus-standard-imaging-in-gynecologic-oncology
#1
Alessia Aloisi, Yukio Sonoda, Ginger J Gardner, Kay J Park, Sarah L Elliott, Qin C Zhou, Alexia Iasonos, Nadeem R Abu-Rustum
BACKGROUND: Narrow band imaging (NBI) is an optic filtration enhancement for endoscopy that uses two wavelengths of light (415 and 540 nm) to highlight superficial microvascular patterns. It has been successfully utilized to improve identification of lesions with abnormal vasculature, which is associated with endometriosis and endometrial cancer. Case studies suggest it may also facilitate surgical staging of gynecologic cancer, which is critical in determining appropriate adjuvant therapies...
January 16, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29340051/microrna-34a-inhibits-cells-proliferation-and-invasion-by-downregulating-notch1-in-endometrial-cancer
#2
Zhen Wang, Wei Wang, Kangrong Huang, Yueling Wang, Jing Li, Xinyuan Yang
MicroRNAs (miRNAs) are small non-coding RNAs composed of 18-25 nucleotides that regulate the expression of approximately 30% of human protein coding genes. Dysregulation of miRNAs plays a pivotal role in the initiation and progression of malignancies. Our study has shown that microRNA-34a (miR-34a) was upregulated in human endometrial cancer stem cells (ECSCs). However, it is unknown how miR-34a regulates endometrial cancer itself. Here, we report that miR-34a directly and functionally targeted Notch1. MiR-34a inhibited the proliferation, migration, invasion, EMT-associated phenotypes by downregulating Notch1 in endometrial cancer cells...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339452/effects-of-colostrum-feeding-method-and-oral-igf1-on-porcine-uterine-development
#3
Ashley F George, Kathleen M Rahman, Dori J Miller, Anne A Wiley, Meredith E Camp, Frank Bartol, Carol A Bagnell
Nursing ensures lactocrine delivery of maternally-derived, milk-borne bioactive factors to offspring, which affects postnatal development of female reproductive tract tissues. Disruption of lactocrine communication for two days from birth (postnatal day = PND 0) by feeding milk replacer in lieu of nursing or consumption of colostrum alters porcine uterine gene expression globally by PND 2 and inhibits uterine gland genesis by PND 14. Here, objectives were to determine effects of: 1) nursing or milk replacer feeding from birth; 2) a single dose of colostrum or milk replacer and method of feeding; and 3) a single feeding of colostrum or milk replacer, with or without oral supplementation of IGF1, administered at birth on aspects of porcine uterine development at 12 h postnatally...
January 16, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29339300/robotic-surgery-in-elderly-and-very-elderly-gynecologic-cancer-patients
#4
Valerio Gallotta, Carmine Conte, Marco D'Indinosante, Alex Federico, Antonella Biscione, Giuseppe Vizzielli, Carolina Bottoni, Maria Vittoria Carbone, Francesco Legge, Stefano Uccella, Pierpaolo Ciocchetti, Andrea Russo, Lorenzo Polidori, Giovanni Scambia, Gabriella Ferrandina
STUDY OBJECTIVE: To investigate feasibility, safety and short-term outcomes of robotic surgery (RS) for gynecological oncologic indications (cervical, endometrial and ovarian cancer) in elderly patients, especially women aged from 65 to 74 (Elderly group - EG), compared to women ≥ 75 (Very Elderly group - VEG). DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: Catholic University of the Sacred Hearth, Rome, Italy...
January 12, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29338923/minimally-invasive-hysterectomy-surgery-rates-for-endometrial-cancer-performed-at-national-comprehensive-cancer-network-nccn-centers
#5
Jennifer Bergstrom, Alessia Aloisi, Shannon Armbruster, Ting-Tai Yen, Jvan Casarin, Mario M Leitao, Edward J Tanner, Rayna Matsuno, Karime Kalil Machado, Sean C Dowdy, Pamela T Soliman, Stephanie L Wethington, Rebecca L Stone, Kimberly L Levinson, Amanda N Fader
OBJECTIVES: Minimally invasive surgery (MIS) is a quality measure for endometrial cancer (EC) established by the Society of Gynecologic Oncology and the American College of Surgeons. Our study objective was to assess the proportion of EC cases performed by MIS at National Comprehensive Cancer Network (NCCN) centers and evaluate perioperative outcomes. METHODS: A retrospective cohort study of women who underwent surgical treatment for EC from 2013 to 2014 was conducted at four NCCN centers...
January 12, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29338855/vitrified-blastocyst-transfer-cycles-with-the-use-of-only-vaginal-progesterone-replacement-with-endometrin-have-inferior-ongoing-pregnancy-rates-results-from-the-planned-interim-analysis-of-a-three-arm-randomized-controlled-noninferiority-trial
#6
Kate Devine, Kevin S Richter, Eric A Widra, Jeffrey L McKeeby
OBJECTIVE: To assess the noninferiority of vaginal P (Endometrin) compared with daily intramuscular P for replacement in programmed vitrified-warmed blastocyst transfer cycles and to assess the noninferiority of vaginal P in combination with intramuscular progesterone every third day compared with daily intramuscular P. DESIGN: Three-arm randomized controlled noninferiority study. To enable early recognition of inferiority if present, an a priori interim analysis was planned and completed once ongoing pregnancy data were available for 50% of the total enrollment goal...
January 12, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29338827/risk-factors-of-intrauterine-adhesion-after-hysteroscopic-resection-of-endometrial-polyps
#7
Li Su, Lan You, Hong Ping Huang
Objective To analyze the risk factors of intrauterine adhesion (IUA) after hysteroscopic resection of endometrial polyps. Methods Totally 359 patients undergoing hysteroscopic resection of endometrial polyps from January 2013 to December 2016 were enrolled in this study. The clinical data of IUA group and non-IUA group were compared. Univariate analysis was performed to identify the risk factors of IUA,and multivariate Logistic regression analysis was further performed to get the independent risk factors. Results Of these 359 patients,IUA occured after operation in 56 patients (15...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29337778/pelvic-pain-and-quality-of-life-before-and-after-laparoscopic-bowel-resection-for-rectosigmoid-endometriosis-a-prospective-observational-study
#8
Mads Riiskjær, Axel Forman, Ulrik S Kesmodel, Lars M Andersen, Ken Ljungmann, Mikkel Seyer-Hansen
BACKGROUND: Surgery for rectosigmoid endometriosis carries a substantial risk of short- and long-term complications, which has to be counterbalanced against the potential effect of the procedure. Prospective data are scarce in the field of deep infiltrating endometriosis surgery. OBJECTIVE: The study aimed to assess pelvic pain and quality of life before and after laparoscopic bowel resection for rectosigmoid endometriosis. DESIGN: The study involved prospectively collected data regarding pelvic pain and quality of life before and after surgery...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29337766/worrying-about-postoperative-functional-outcomes-in-young-women-with-colorectal-endometriosis-that-s-it
#9
Jean-Jacques Tuech, Horace Roman
No abstract text is available yet for this article.
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29337420/a-proinflammatory-response-of-bovine-endometrial-epithelial-cells-to-active-sperm-in-vitro
#10
Ahmed Essam Elweza, Mohamed Aboul Ezz, Tomas J Acosta, Anup K Talukder, Takashi Shimizu, Hiroyuki Hayakawa, Masayuki Shimada, Kazuhiko Imakawa, Ahmed Hamed Zaghloul, Akio Miyamoto
In the cow, cryopreserved semen is inseminated into the uterus, and most of sperm are removed by backflow and phagocytes. Nevertheless, the mechanism responsible for sperm phagocytosis is unclear. Here, we used cultured bovine uterine epithelial cells (BUECs) to investigate the uterine response to sperm and the mechanism that activates polymorphonuclear neutrophils (PMNs). BUEC monolayers were co-cultured with different numbers of washed sperm obtained from cryopreserved semen (104 , 105 and 106 sperm/ml) for 3 h...
January 16, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29337211/extraperitoneal-para-aortic-lymphadenectomy-by-robot-assisted-laparoscopy
#11
Ana Gomes da Costa, Yves Borghesi, Delphine Hudry, Julie Faes, Lucie Bresson, Fabrice Narducci, Eric Leblanc
STUDY OBJECTIVE: The aim of this study was to evaluate the outcomes of extraperitoneal para-aortic lymphadenectomy by robot-assisted laparoscopy. DESIGN: A retrospective study (Canadian Task Force classification III). SETTING: An academic institution. PATIENTS: Twenty-three consecutive patients with gynecologic cancer who presented for para-aortic lymphadenectomy between March 2016 and May 2017 were reviewed retrospectively...
January 11, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29336106/best-practice-perioperative-strategies-and-surgical-techniques-for-preventing-caesarean-section-surgical-site-infections-a-systematic-review-of-reviews-and-meta-analyses
#12
Elizabeth K Martin, Michael M Beckmann, Louise N Barnsbee, Kate A Halton, Katharina M D Merollini, Nicholas Graves
BACKGROUND: Surgical site infection (SSI) following caesarean section is a problem for women and health services. Caesarean section is a high volume procedure and the estimated incidence of SSI may be as high as 9%. OBJECTIVES: The objective of this study was to identify a suite of perioperative strategies and surgical techniques that reduce the risk of SSI following caesarean section. SEARCH STRATEGY: Six electronic databases were searched to systematically review literature reviews, systematic reviews and meta-analyses published from 2006 to 2016...
January 16, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29335465/the-high-concentration-of-progesterone-is-harmful-for-endometrial-receptivity-and-decidualization
#13
Yu-Xiang Liang, Li Liu, Zhi-Yong Jin, Xiao-Huan Liang, Yong-Sheng Fu, Xiao-Wei Gu, Zeng-Ming Yang
Progesterone is required for the establishment and maintenance of mammalian pregnancy and widely used for conservative treatment of luteal phase deficiency in clinics. However, there are limited solid evidences available for the optimal timing and dose of progesterone therapy, especially for the possible adverse effects on implantation and decidualization when progesterone is administrated empirically. In our study, mouse models were used to examine effects of excess progesterone on embryo implantation and decidualization...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335207/synthesis-and-biological-evaluation-of-3-2-aminoethyl-uracil-derivatives-as-gonadotropin-releasing-hormone-gnrh-receptor-antagonists
#14
Seon-Mi Kim, Minhee Lee, So Young Lee, Soo-Min Lee, Eun Jeong Kim, Jae Sun Kim, Jihyae Ann, Jiyoun Lee, Jeewoo Lee
We investigated a series of uracil analogues by introducing various substituents on the phenyl ring of the N-3 aminoethyl side chain and evaluated their antagonistic activity against human gonadotropin-releasing hormone (GnRH) receptors. Analogues with substituents at the ortho or meta position demonstrated potent in vitro antagonistic activity. Specifically, the introduction of a 2-OMe group enhanced nuclear factor of activated T-cells (NFAT) inhibition up to 6-fold compared to the unsubstituted analogue...
January 2, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29334789/circular-rna-expression-in-ovarian-endometriosis
#15
Licong Shen, Yu Zhang, Wenjun Zhou, Zheng Peng, Xiaxia Hong, Yi Zhang
AIM: Circular RNAs (circRNAs) with miRNA response elements (MREs) could function as competing endogenous RNA (ceRNA) in regulating gene expression. This study was carried out to identify the expression profile and role of circRNAs in endometriosis. MATERIALS & METHODS: Microarray assay was performed in four paired ovarian endometriomas and eutopic endometrium, followed by quantitative real-time RT-PCR in 24 paired samples. Bioinformatical algorithms were used to predict MREs, as well as ceRNA and KEGG pathway analysis...
January 16, 2018: Epigenomics
https://www.readbyqxmd.com/read/29334253/circular-rna-expression-in-extracellular-vesicles-isolated-from-serum-of-patients-with-endometrial-cancer
#16
Hanzi Xu, Zhen Gong, Yang Shen, Yichen Fang, Shanliang Zhong
AIM: We aimed to explore the roles of circular RNAs (circRNAs) in extracellular vesicles (EVs) isolated from serum of patients with endometrial cancer. MATERIALS & METHODS: EVs were isolated from serum samples of three patients with stage III adenocarcinoma aged 50-60 years and three matched healthy controls. RNA was extracted from the EVs and analyzed using RNA-seq technique. RESULTS: We got 209 upregulated circRNAs and 66 downregulated circRNAs...
January 15, 2018: Epigenomics
https://www.readbyqxmd.com/read/29334213/conservative-management-of-ovarian-fibroma-in-a-case-of-gorlin-goltz-syndrome-comorbid-with-endometriosis
#17
Sepideh Khodaverdi, Leila Nazari, Abolfazl Mehdizadeh-Kashi, Mansoureh Vahdat, Samaneh Rokhgireh, Ali Farbod, Banafsheh Tajbakhsh
Ovarian fibromas are the most common benign solid ovarian tumors, which are often difficult to diagnose preoperatively. Ovarian fibromas, especially in bilateral cases, may be cases of Gorlin-Goltz syndrome (GGS), a rare autosomal dominant disorder with predisposition to basal cell carcinomas (BCCs) and other various benign and malignant tumors. This case report describes a 25 year-old female with GGS, bilateral ovarian fibroma, endometriosis and septated uterus, which was referred to the Gynecology Clinic of Rasoul-e-Akram Hospital in October 2016...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29334205/overexpression-of-endometrial-estrogen-receptor-alpha-in-the-window-of-implantation-in-women-with-unexplained-infertility
#18
Mehran Dorostghoal, Hamid-O-Allah Ghaffari, Farideh Marmazi, Narjes Keikhah
Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha (ER-α) expression during implantation may be a critical event that coincides with the expression of specific genes and the formation of a receptive endometrium. The aim of the present study was to assess the expression of ER-α in the mid-secretory phase in the endometrium of women with unexplained infertility...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29333623/evaluation-of-universal-immunohistochemical-screening-of-sebaceous-neoplasms-in-a-service-setting
#19
K Schon, E Rytina, J Drummond, J Simmonds, S Abbs, R Sandford, M Tischkowitz
BACKGROUND: Muir-Torre syndrome (MTS) is a subtype of Lynch syndrome, which encompasses the combination of sebaceous skin tumours or keratoacanthomas and internal malignancy, due to mutations in DNA mismatch repair genes. Sebaceous neoplasms (SNs) may occur before other malignancies, and may lead to the diagnosis, which allows testing of other family members, cancer surveillance, risk-reducing surgery or prevention therapies. AIM: To evaluate the efficacy of universal immunohistochemistry (IHC) screening of SNs in a service setting...
January 14, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29332864/associations-of-periparturient-plasma-biochemical-parameters-endometrial-leukocyte-esterase-and-myeloperoxidase-and-bacterial-detection-with-clinical-and-subclinical-endometritis-in-postpartum-dairy-cows
#20
Sayed Ahmad Nazhat, Go Kitahara, Nobutoshi Kozuka, Shogo Mido, Mohammed Sadawy, Hossam El-Sheikh Ali, Takeshi Osawa
This study was aimed at demonstrating associations between peripheral biochemical parameters, endometrial leukocyte esterase (LE) and myeloperoxidase (MPO), and bacterial detection with the degree of endometrial inflammation, and determining the best time postpartum for diagnosing endometritis to predict subsequent fertility in dairy cows. Plasma albumin, blood urea nitrogen (BUN), total cholesterol (T-cho), NEFA, and BHBA concentrations were analyzed in 43 Holstein cows at 3, 5 and 7 weeks postpartum (W3, W5 and W7)...
January 12, 2018: Journal of Veterinary Medical Science
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