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https://www.readbyqxmd.com/read/28918284/new-insights-into-human-female-reproductive-tract-development
#1
Stanley J Robboy, Takeshi Kurita, Laurence Baskin, Gerald R Cunha
We present a detailed review of the embryonic and fetal development of the human female reproductive tract utilizing specimens from the 5th through the 22nd gestational week. Hematoxylin and eosin (H&E) as well as immunohistochemical stains were used to study the development of the human uterine tube, endometrium, myometrium, uterine cervix and vagina. Our study revisits and updates the classical reports of Koff (1933) and Bulmer (1957) and presents new data on development of human vaginal epithelium. Koff proposed that the upper 4/5ths of the vagina is derived from Müllerian epithelium and the lower 1/5th derived from urogenital sinus epithelium, while Bulmer proposed that vaginal epithelium derives solely from urogenital sinus epithelium...
August 11, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/28918157/differential-proteomic-profiling-of-endometrium-and-plasma-indicate-the-importance-of-hydrolysis-in-bovine-endometritis
#2
Shi-Dong Zhang, Shu-Wei Dong, Dong-Sheng Wang, Chike F Oguejiofor, Ali A Fouladi-Nashta, Zhi-Qiang Yang, Zuo-Ting Yan
Endometritis is an important disease of dairy cows that leads to significant economic losses in the dairy cattle industry. To investigate the alteration of proteins associated with endometritis in the dairy cow, the isobaric tags for relative and absolute quantification (iTRAQ) technique was applied to quantitatively identify differentially expressed proteins (DEP) in the endometrium and peripheral plasma of Chinese Holstein cows with endometritis. Compared with the normal (control) group, 159 DEP in the endometrium and 137 DEP in the plasma were identified in cows with endometritis...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28917433/surveillance-imaging-in-patients-with-endometrial-cancer-in-first-remission
#3
Yazan Z Alabed, Su-Chun Cheng, Christopher Mudge, Christopher Sakellis, Annick D Van den Abbeele, Susana M Campos, Heather A Jacene
OBJECTIVE: The clinical benefit of surveillance imaging in endometrial cancer remains undefined. This retrospective study was conducted to evaluate the positive predictive value (PPV) of surveillance imaging in endometrial cancer. METHODS: A total of 128 patients in first remission after treatment for endometrial cancer (uterine papillary serous, clear cell, stage III endometroid) who had surveillance imaging were retrospectively identified. The surveillance period was defined from the time of first-negative scan after treatment to the time when treatment was started for recurrent disease...
August 24, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28917127/differential-expression-of-ten-candidate-genes-regulating-prostaglandin-action-in-reproductive-tissues-of-buffalo-during-estrous-cycle-and-pregnancy
#4
Ankita Dillipkumar Verma, Manjit Panigrahi, Naseer Ahmad Baba, Sourabh Sulabh, Abdul Sadam, Subhashree Parida, Krishnaswamy Narayanan, Arvind A Sonwane, Bharat Bhushan
Prostaglandins (PGs) are the key mediators of several female reproductive functions, including luteolysis, ovulation, fertilization, implantation, pregnancy, and parturition. The present study was conducted in buffalo endometrial and luteal tissues between nonpregnant and two stages of pregnancy (29-38 days of pregnancy, 48-56 days of pregnancy) tissue samples. The genes involved from synthesis upto receptor level effect of PGs (PGF2α and PGE2) were studied for their relative mRNA expression. We have collected the endometrial and luteal tissues from slaughtered animals and confirmed the stages by external examination and crown vertebral rump length measurement of the foetus...
September 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/28917021/gynecologic-cancer-mortality-in-trinidad-and-tobago-and-comparisons-of-mortality-to-incidence-rate-ratios-across-global-regions
#5
Adana A M Llanos, Wayne A Warner, Silvana Luciani, Tammy Y Lee, Smriti Bajracharya, Simeon Slovacek, Veronica Roach, Marjorie Lamont-Greene
PURPOSE: To examine the factors associated with gynecologic cancer mortality risks, to estimate the mortality-to-incidence rate ratios (MIR) in Trinidad and Tobago (TT), and to compare the MIRs to those of select countries. METHODS: Data on 3,915 incident gynecologic cancers reported to the National Cancer Registry of TT from 1 January 1995 to 31 December 2009 were analyzed using proportional hazards models to determine factors associated with mortality. MIRs for cervical, endometrial, and ovarian cancers were calculated using cancer registry data (TT), GLOBOCAN 2012 incidence data, and WHO Mortality Database 2012 data (WHO regions and select countries)...
September 15, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28916679/retraction-cyp1b1-gene-polymorphisms-have-higher-risk-for-endometrial-cancer-and-positive-correlations-with-estrogen-receptor-%C3%AE-and-estrogen-receptor-%C3%AE-expressions
#6
(no author information available yet)
No abstract text is available yet for this article.
September 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28916367/rucaparib-maintenance-treatment-for-recurrent-ovarian-carcinoma-after-response-to-platinum-therapy-ariel3-a-randomised-double-blind-placebo-controlled-phase-3-trial
#7
Robert L Coleman, Amit M Oza, Domenica Lorusso, Carol Aghajanian, Ana Oaknin, Andrew Dean, Nicoletta Colombo, Johanne I Weberpals, Andrew Clamp, Giovanni Scambia, Alexandra Leary, Robert W Holloway, Margarita Amenedo Gancedo, Peter C Fong, Jeffrey C Goh, David M O'Malley, Deborah K Armstrong, Jesus Garcia-Donas, Elizabeth M Swisher, Anne Floquet, Gottfried E Konecny, Iain A McNeish, Clare L Scott, Terri Cameron, Lara Maloney, Jeff Isaacson, Sandra Goble, Caroline Grace, Thomas C Harding, Mitch Raponi, James Sun, Kevin K Lin, Heidi Giordano, Jonathan A Ledermann
BACKGROUND: Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-wide loss of heterozygosity. In this trial we assessed rucaparib versus placebo after response to second-line or later platinum-based chemotherapy in patients with high-grade, recurrent, platinum-sensitive ovarian carcinoma. METHODS: In this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited patients from 87 hospitals and cancer centres across 11 countries...
September 12, 2017: Lancet
https://www.readbyqxmd.com/read/28916118/benefit-of-combination-chemotherapy-and-radiation-stratified-by-grade-of-stage-iiic-endometrial-cancer
#8
Pratibha S Binder, Lindsay M Kuroki, Peinan Zhao, Sarah Cusworth, Laura M Divine, Andrea R Hagemann, Carolyn K McCourt, Premal H Thaker, Matthew A Powell, David G Mutch, L Stewart Massad
OBJECTIVE: The optimal strategy for adjuvant therapy in stage IIIC endometrial cancer has not been determined. Our aim was to evaluate survival benefit of different treatments and to investigate if benefit varied by histologic grade. METHODS: We identified 199 patients with stage IIIC endometrial cancer from 2000 to 2012 through the Siteman Cancer Center registry. All patients underwent surgical staging followed by no adjuvant therapy (NAT), radiation (RT), chemotherapy (CT) or chemoradiation (CRT)...
September 12, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28915910/colonization-of-the-bovine-uterus-by-candida-kefyr
#9
Cecilia Christensen Karstrup, Bent Aalbæk, Kirstine Klitgaard, Tim Kåre Jensen, Hanne Gervi Pedersen, Jørgen Steen Agerholm
BACKGROUND: While fungal infections of the bovine uterus are well-known diseases in pregnant cattle, very limited knowledge exists on the presence and significance of fungi in the uterus of non-pregnant cows. Presence of fungi in the uterine lumen of postpartum (pp) cows has been reported, but little attention has been paid to this as most studies of the bovine pp uterus have focused on bacteria. CASE PRESENTATION: Microscopy of uterine lavage cytology slides of three cows from one herd revealed the presence of numerous yeast-like organisms, which were located either free in the fluid or within macrophages...
September 16, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28915701/comparison-among-fertility-sparing-therapies-for-well-differentiated-early-stage-endometrial-carcinoma-and-complex-atypical-hyperplasia
#10
REVIEW
Qing Zhang, Gonghua Qi, Margaux J Kanis, Ruifen Dong, Baoxia Cui, Xingsheng Yang, Beihua Kong
OBJECTIVE: To compare fertility-sparing therapies including oral progestogens, hysteroscopic resection (HR), and the levonorgestrel- releasing intrauterine system (LNG-IUS) in achieving disease regression, recurrence and live birth rate in well differentiate early-stage endometrial carcinoma (eEC) and complex atypical hyperplasia(CAH). STUDY DESIGN: This was a meta-analysis of previous studies focus on the fertility-sparing therapy for well differentiate early-stage endometrial carcinoma (eEC) and complex atypical hyperplasia (CAH)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915409/androgen-receptor-cytosine-adenine-and-guanine-trinucleotide-repeat-polymorphism-in-korean-patients-with-endometriosis-a-case-control-study
#11
Jae Jun Shin, Young Min Choi, Hwa Young Choi, Soo Jin Chae, Kyuri Hwang, Jin Ju Kim, Gyoung Hoon Lee, Jong Mi Kim
STUDY OBJECTIVE: To investigate the association between the androgen receptor (AR) cytosine, adenine, and guanine (CAG) repeat polymorphisms and endometriosis. STUDY DESIGN: A prospective case-control, genetic association study was performed on women with surgically proven endometriosis (n=421) and controls free of endometriosis (n=349). AR CAG repeat lengths were determined from peripheral blood samples. The difference in the frequency of each alleles were compared in patients with endometriosis and controls using Chi-square test...
September 8, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28914881/microrna-200c-impairs-uterine-receptivity-formation-by-targeting-fut4-and-%C3%AE-1-3-fucosylation
#12
Qin Zheng, Dandan Zhang, Y U Yang, Xinyuan Cui, Jiaqi Sun, Caixia Liang, Huamin Qin, Xuesong Yang, Shuai Liu, Qiu Yan
Successful embryo implantation requires the establishment of a receptive endometrium. Poor endometrial receptivity has generally been considered as a major cause of infertility. Protein glycosylation is associated with many physiological and pathological processes. The fucosylation is catalyzed by the specific fucosyltransferases. Fucosyltransferase IV (FUT4) is the key enzyme for the biosynthesis of α1,3-fucosylated glycans carried by glycoproteins, and the previous studies showed FUT4 expression changed dynamically during perimplantation...
September 15, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28914717/the-relationship-between-mismatch-repair-deficiency-and-pd-l1-expression-in-breast-carcinoma
#13
Anne M Mills, Erik A Dill, Christopher A Moskaluk, Jaroslaw Dziegielewski, Tim N Bullock, Patrick M Dillon
Mismatch repair (MMR) deficiency in solid tumors has recently been linked to susceptibility to immunotherapies targeting the programmed cell death-1 (PD-1)/programmed cell death-1 ligand (PD-L1) axis. Loss of MMR proteins has been shown to correlate with tumoral PD-L1 expression in colorectal and endometrial carcinomas, but the association between expression of MMR proteins and PD-L1 has not previously been studied in breast carcinoma, where MMR deficiency is less common. We assessed the relationship between PD-L1 and MMR protein expression by immunohistochemistry in 245 primary and 40 metastatic breast carcinomas...
September 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28914672/endometrial-changes-in-surgical-specimens-of-perimenopausal-patients-treated-with-ulipristal-acetate-for-uterine-leiomyomas
#14
Francisco F Nogales, Vicente Crespo-Lora, Nelly Cruz-Viruel, Clara Chamorro-Santos, Christine Bergeron
Ulipristal acetate (UPA) is used to treat leiomyomas, and its effect on the endometrium has been studied in biopsy material. Reversible histologic modifications were found, named progesterone receptor modulators-associated endometrial changes (PAEC). However, hysterectomies from patients treated with UPA have not been analyzed. For the first time, we examined surgical specimens from 100 leiomyoma-treated patients for UPA-related endometrial changes. We analyzed the distribution of lesions, involution after treatment, and the relationship between type and extent of lesions and dosage...
September 13, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28914671/endometrial-polyps-and-benign-endometrial-hyperplasia-present-increased-prevalence-of-dna-fragmentation-factors-40-and-45-dff40-and-dff45-together-with-the-antiapoptotic-b-cell-lymphoma-bcl-2-protein-compared-with-normal-human-endometria
#15
Tomasz Banas, Kazimierz Pitynski, Marcin Mikos, Joanna Cielecka-Kuszyk
DNA fragmentation factor 40 (DFF40) is a key executor of apoptosis. It localizes to the nucleus together with DNA fragmentation factor 45 (DFF45), which acts as a DFF40 inhibitor and chaperone. B-cell lymphoma (Bcl-2) protein is a proven antiapoptotic factor present in the cytoplasm. In this study, we aimed to investigate DFF40, DFF45, and Bcl-2 immunoexpression in endometrial polyps (EPs) and benign endometrial hyperplasia (BEH) tissue compared with that in normal proliferative endometrium (NPE) and normal secretory endometrium (NSE) as well as normal post menopausal endometrium (NAE)...
September 13, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28914670/endometrial-stromal-neoplasm-in-the-placenta-report-of-a-case-and-review-of-the-literature
#16
Debra S Heller, Fadi Hatem
Placental neoplasms involving the fetal membranes are exceptionally rare. In leiomyomas and endometrial stromal neoplasms, a uterine origin for nodules in the membranes is also a possibility. We present a case of an incidental endometrial stromal nodule found in the decidua of the free membranes and review the literature.
September 13, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28914561/oral-and-depot-progestin-therapy-for-endometriosis-towards-a-personalized-medicine
#17
Laura Buggio, Edgardo Somigliana, Giussy Barbara, Maria Pina Frattaruolo, Paolo Vercellini
Endometriosis is an estrogen-dependent chronic inflammatory disorder that requires a life-long management plan. Long-term adherence to treatment is pivotal to ensure an effective clinical management. In this optic, one of the cornerstone of endometriosis medical treatment is represented by progestins. Areas covered: This narrative review examines the clinical efficacy, safety and tolerability of oral and depot progestins used in the treatment of endometriosis. The material included in the current manuscript was obtained with a MEDLINE search through PubMed from inception until January 2017...
September 15, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28913973/bone-marrow-stem-cells-do-not-contribute-to-endometrial-cell-lineages-in-chimeric-mouse-models
#18
Yih Rue Ong, Fiona L Cousins, Xiaoqing Yang, Ahmed Aedh A Al Mushafi, David T Breault, Caroline E Gargett, James A Deane
Studies from five independent laboratories conclude that bone marrow stem cells transdifferentiate into endometrial stroma, epithelium and endothelium. We investigated the nature of bone marrow-derived cells in the mouse endometrium by reconstituting irradiated wild type recipients with bone marrow containing transgenic mTert-GFP or chicken β-actin-GFP reporters. mTert-GFP is a telomerase marker identifying hematopoietic stem cells and subpopulations of epithelial, endothelial and immune cells in the endometrium...
September 15, 2017: Stem Cells
https://www.readbyqxmd.com/read/28913150/features-of-ovarian-brenner-tumors-experience-of-a-single-tertiary-center
#19
Batuhan Turgay, Kazibe Koyuncu, Salih Taşkın, Uğur Fırat Ortaç
OBJECTIVE: Brenner tumors are rare neoplasms of the ovary. The aim of this study was to investigate the clinical features of Brenner tumors. MATERIALS AND METHODS: The clinical features of 22 patients who were treated in Ankara University Faculty of Medicine Obstetrics and Gynecology Department between 2005 and 2015 were evaluated retrospectively from hospital medical records. RESULTS: The patients were aged 34 to 79 years at the time of diagnosis and the mean age was 55...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28913149/comparison-of-libido-female-sexual-function-index-and-arizona-scores-in-women-who-underwent-laparoscopic-or-conventional-abdominal-hysterectomy
#20
Semra Kayataş, Enis Özkaya, Murat Api, Seyhan Çıkman, Ayşen Gürbüz, Ahmet Eser
OBJECTIVE: The aim of the present study was to compare female sexual function between women who underwent conventional abdominal or laparoscopic hysterectomy. MATERIALS AND METHODS: Seventy-seven women who were scheduled to undergo hysterectomy without oophorectomy for benign gynecologic conditions were included in the study. The women were assigned to laparoscopic or open abdominal hysterectomy according to the surgeons preference. Women with endometriosis and symptomatic prolapsus were excluded...
June 2017: Turk J Obstet Gynecol
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